18 th Belgian Congress on Rheumatology. Organised by the Belgian Royal Society for Rheumatology. 24-26 September 2014 The Wild Gallery, Brussels



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18 th Belgian Congress on Rheumatology Organised by the Belgian Royal Society for Rheumatology 24-26 September 2014 The Wild Gallery, Brussels Scientific Organiser Rik Lories Local Organising Committee Silvana Di Romana Muriel Moris Anne Peretz Final Programme www.rheumacongress.be

Scientific Organiser Rik Lories KU Leuven Herestraat 49, 3000 Leuven Phone: 016 / 342541 Email: Rik.Lories@uz.kuleuven.be Local Organising Committee Silvana Di Romana CHU Saint Pierre rue Haute 322, 1000 Bruxelles Phone: 02 / 5067383 Email: silvana_diromana@stpierre-bru.be Muriel Moris Militair Hospitaal Koningin Astrid - Hôpital Militaire Reine Astrid Bruynstraat 1, 1120 Neder-over-Heembeek Phone: 02 / 2644724 Email: dr.muriel.moris@telenet.be Anne Peretz CHU Brugmann Place Van Gehuchten 4, 1020 Bruxelles Phone: 02 / 4773519 Email: anne.peretz@chu-brugmann.be Venue The Wild Gallery 11 rue du Charroi / Gerijstraat 11 1190 Forest / Vorst Web: www.wildgallery.be Congress Secretariat Medicongress Services Noorwegenstraat 49 B-9940 Evergem, Belgium Phone: +32 (0)9 218 85 81 Fax: +32 (0)9 344 40 10 Email: reumato@medicongress.com Web: www.medicongress.com Welcome to Brussels Dear colleagues and friends, As Organising Committee, we are very pleased to welcome you to the 18th Belgian Congress on Rheumatology, taking place in Brussels on September 24-26, 2014. The Congress will take place at the Wild Gallery, a spacious post-industrial building dating back to 1902, with an Art Deco architectural style. As you may know the format of the congress has been changed: we will start earlier on Wednesday and finish earlier on Friday. The scientific programme has been coordinated by Prof. Rik Lories, who was able to put together a varied and interesting programme with state-of-the-art keynote lectures, and four sessions of oral poster presentations. Furthermore seven Updates in Therapeutics are scheduled. New this year are the 4 hands-on Workshops, free of charge, but limited to 20 participants each, two quizzes where your active participation is essential and two poster tours, one clinical tour and one translational/basic tour. We look forward to welcoming you to Brussels! Silvana Di Romana, Muriel Moris and Anne Peretz 2 www.rheumacongress.be www.rheumacongress.be 3

Wednesday, September 24 09.30 Pre-Congress Meetings KBVR SRBR Board Meeting Meeting of the BRV - Belgische Reumatologen Vereniging / ARB - Association des médecins rhumatologues de Belgique 10.00 YOUNG INVESTIGATOR MEETING Effective modulation of GPR22 signalling in chondrocytes Laura-An Guns, R.J. Lories, F. Cailotto SMOC2 modulates chondrogenesis by interfering with Wnt and BMP signaling pathways Frédéric Cailotto, F.P. Luyten, R.J. Lories Distinct dysregulation of the small leucine-rich repeat protein (SLRP) family in osteoarthritic labrum compared to articular cartilage Nele Juchtmans, A.A.M. Dhollander, J. Coudenys, E.A. Audenaert, C. Pattyn, S. Lambrecht, D. Elewaut Seroconversion and fluctuation of current and novel biomarkers during disease course of RA Liesbeth De Winter, W. Hansen, P. Geusens, J. Vanhoof, P. Stinissen, V. Somers Leptin expression is restricted to dedifferentiated state in human chondrocytes and rely on ALK1/Smad1-5 and β-catenin activation Edith Charlier, B. Relica, O. Malaise, S. Neuville, G. Cobraiville, P. Gillet, W. Kurth, D. de Seny, M.G. Malaise Leptin production by osteoarthritis synovial fibroblasts: Stimulation by glucocorticoids and mineralocorticoids through the glucocorticoid receptor and GILZ (Glucocorticoid-Induced Leucine Zipper) protein Olivier Malaise, B. Relic, S. Neuville, E. Charlier, D. de Seny, M.G. Malaise Modulating the ratio of saturated/monounsaturated free fatty acids via induction of Stearoyl-CoA desaturase-1 protects hmsc against lipotoxicity Antoine Dalla Valle, D. Spruyt, C. Gillet, J. Lechanteur, N. Gaspard, S. Rigutto, V. Gangji, J. Rasschaert Wednesday, September 24 12.30 Opening Ceremony and Award Presentation SESSION 1 13.00 Uveitis for the rheumatologist Joachim Vancalster (KUL) 13.30 Personalized medicine in rheumatology Bernard Lauwerys (UCL) 14.00 Selected Abstract Presentations 14.30 Quiz 1 Associated with a glucocorticoid bridging scheme, methotrexate is as effective alone as in combination with other DMARDS for early rheumatoid arthritis, with fewer reported side effects: 16 weeks remission induction data from the Carera trial Diederik De Cock, P. Verschueren, L. Corluy, R. Joos, C. Langenaken, V. Taelman, F. Raeman, I. Ravelingien, K. Vandevyvere, J. Lenaerts, E. Geens, P. Geusens, J. Van Hoof, A. Durnez, J. Remans, B. Vander Cruyssen, E. Van Essche, A. Sileghem, G. De Brabanter, J. Joly, S. Meyfroidt, K. Van der Elst, R. Westhovens Microscopic gut inflammation in SpA is a prognostic factor for initiation of anti-tnf therapy in daily practice Heleen Cypers, G. Varkas, L. Van Praet, F. Van den Bosch, D. Elewaut Glucocorticoid dose reduction in patients with low disease activity using tocilizumab: The ACT-Alone study Clio Ribbens, J. Vanhoof, M. Maertens, M. Van Steenberghe, P. Verschueren 15.00 Coffee Break 12.00 Welcome Lunch 4 www.rheumacongress.be www.rheumacongress.be 5

Wednesday, September 24 SESSION 2 15.30 Vesalius Lecture Rheumatoid Arthritis: Redefined by genetics and autoantibodies Lars Klareskog (Stockholm, Sweden) 16.10 Belgian Rheumatology in Review Overview of Belgian contributions to basic and translational science Marco Hirsch (ZithaKlinik Luxembourg) & Clio Ribbens (CHU de Liège) 16.30 Update in Therapeutics Roche 17.00 Update in Therapeutics Pfizer 17.30 Walking Dinner SESSION 3 Ethics and Economy 19.00 The Mdeon code of ethics - Interaction between the industry and the healthcare professionals Stéphanie Brillon, Directeur Mdeon asbl vzw 20.30 Coffee Break 21.00 Biosimilars: The Belgian view René Westhovens (KUL) 22.30 Adjourn Thursday, September 25 Hands-on Workshops 07.30 Workshop 1: SLEDAI and BILAG Frédéric Houssiau (UCL) & Christian Von Frenckell (CHU de Liège) 07.30 Workshop 2: The foot! René Westhovens (KUL) & Sophie De Mits (UZ Gent) SESSION 4 08.30 Diagnosis and management of osteonecrosis Valérie Gangji (ULB) 09.00 Selected abstract presentations The effect of a running exercise on knee-joints of Dio2-/--mice; identifying pathways involved in cartilage degradation processes following mechanical stress Frederique M.F. Cornelis, N. Bomer, Y.F.M. Ramos, N. Lakenberg, R. van der Breggen, W. den Hollander, L. Storms, P.E. Slagboom, I. Meulenbelt, R.J. Lories A semi-automated method for defining cortical bone breaks in cadaveric finger joints using high-resolution peripheral QCT and microct M. Peters, A. Scharmga, A. van Tubergen, J. van den Bergh, B. van Rietbergen, Piet Geusens Apremilast, an oral phosphodiesterase 4 inhibitor, in patients with psoriatic arthritis: Results of phase 3, randomized, placebocontrolled trials (PALACE 1, 2, and 3) Kurt de Vlam, F.J. Blanco, A. Kavanaugh, A.O. Adebajo, C.J. Edwards, J. Crowley, R.M. Stevens, C. Hu, P. Mease 09.30 Cartilage repair: Entering a new decade Frank Luyten (KUL) 10.00 Coffee Break 6 www.rheumacongress.be www.rheumacongress.be 7

Thursday, September 25 SESSION 5 10.40 Belgian Rheumatology in Review Overview of Belgian contributions to clinical research Jan Lenaerts (Hasselt) & Patrick Verschueren (KUL) 11.00 Update in Therapeutics UCB Pharma 11.30 Update in Therapeutics MSD Belgium 12.00 Lunch 13.00 Poster tour: 1 Clinical Poster Tour & 1 Translational/Basic Poster Tour SESSION 6 14.00 General Assembly (Part I) & Vote 14.30 Update in Therapeutics - ABBVIE 15.00 How to treat gout in 2014? Thomas Bardin (Paris, France) 15.30 Coffee Break SESSION 7 16.00 Boost performance in work and leisure in arthritis patients Philip Carron (UZ Gent) 16.30 Selected abstract presentations High prevalence of undiagnosed axial SpA in patients below 45 years of age with chronic back pain visiting physiotherapists, orthopedists and ophthalmologists (SUSPECT study) V. Gangji, Laure Tant, N. Delmotte, M. Van den Enden, H. Mielants An exploration of the relative importance of barriers hindering intensive combination treatment strategies in early rheumatoid arthritis Sabrina Meyfroidt, M. Hulscher, D. De Cock, K. Van der Elst, J. Joly, R. Westhovens, P. Verschueren Factors influencing the occupational trajectory of patients with systemic sclerosis: A qualitative study Saskia Decuman, V. Smith, M. Grypdonck, F. De Keyser, S. Verhaeghe Friday, September 26 Hands-on Workshops 07.30 Workshop 3: Capillaroscopy Vanessa Smith (UZ Gent) 07.30 Workshop 4: Work disability evaluation Saskia Decuman (UZ Gent) & Xavier Janssens (Gent) SESSION 8 08.30 Biologics in lupus: Hope or despair Frédéric Houssiau (UCL) 09.00 Selected abstract presentations Dissection of the type I interferon response in systemic lupus erythematosus: Serum IFNa is elevated in lupus nephritis, and IFNb in mucocutaneous disease Julie Ducreux, S. Nieuwland-Husson, F.A. Houssiau, B.R. Lauwerys A multicenter, prospective cohort study using NailfoldVideo- Capillaroscopy (NVC) and other factors to determine the risk of developing digital ulceration in patients with systemic sclerosis: the CAP study M. Cutolo, A. Herrick, O. Distler, M. Becker, E. Beltran, P. Carpentier, C. Ferri, M. Inanç, P. Vlachoyiannopoulos, H. Chadha-Boreham, E. Cottreel, T. Pfister, D. Rosenberg, J. Torres, Vanessa Smith, on behalf of the CAP study investigators The 10-year follow-up of the MAINTAIN nephritis trial comparing azathioprine and mycophenolate mofetil for long-term immunosuppression of lupus nephritis Farah Tamirou, D. D Cruz, S. Sangle, P. Remy, C. Vasconcelos, C. Fiehn, E. de Ramon Garrido, I.-M. Gilboe, M. Tektonidou, D. Blockmans, I. Ravelingien, V. le Guern, G. Depresseux, L. Guillevin, R. Cervera, F.A. Houssiau for the MAINTAIN Nephritis Trial Group 17.00 General Assembly (Part II) & Results of the Vote 8 www.rheumacongress.be www.rheumacongress.be 9

Friday, September 26 09.30 Bone and Joint Lecture Skeletal syndromes - From discovery to biology Wim Van Hul (UA) 10.00 Coffee Break SESSION 9 10.40 Quiz 2 11.00 Update in Therapeutics Janssen-Cilag 11.30 Update in Therapeutics BMS 12.00 Closure of the Congress 12.30 Lunch 14.00 Meeting of the Paritair Comité / Comité Paritaire Thursday, September 25 Meeting for Health Professionals in Rheumatology - Morning Organised by the Belgian Health Professionals in Rheumatology (BHPR) vzw/asbl Chairpersons: Marie Avaux 1 and Thijs Swinnen 2 1 Physical therapist, Dept. of Rheumatology, Université Catholique de Louvain; Vice-president BHPR vzw asbl 2 Physical therapist, Division of Rheumatology, University Hospitals Leuven; PhD candidate, Skeletal Biology and Engineering Research Center, Dept. of Development and Regeneration; Research Group for Musculoskeletal Rehabilitation, Dept. of Rehabilitation Sciences, KU Leuven; President BHPR vzw asbl 08.45 Registration* 09.00 Welcome to the Health Professionals in Rheumatology meeting** Marie Avaux, Thijs Swinnen 09.10 How to make client-centered care effective? Saskia Decuman Occupational therapist, Disability Case Manager, PhD student, Dept. of Internal Medicine, Faculty of Medicine and Health Sciences, Ghent University, Secretary BHPR vzw asbl Karlien Claes Specialist rheumatology nurse, Dept. of Rheumatology, Ghent University Hospital, Founding member BHPR vzw 09.30 Case 1: Round table discussion across disciplines (French and Dutch) An Van Boxstael Specialist rheumatology nurse, Disability Case Manager, OLV Ziekenhuis Aalst-Asse-Ninove, Treasurer BHPR vzw asbl Thijs Swinnen Yvonne Van Eijk-Hustings Specialist rheumatology nurse and health care scientist, PhD, Dept. of Patient & Care, Dept. of Rheumatology, AZ Maastricht 10.30 Coffee Break 11.00 The foot is easily forgotten in rheumatology: A practical session Rene Westhovens Rheumatologist, Division of Rheumatology, University Hospitals Leuven; Skeletal Biology and Engineering Research Center, Dept. of Development and Regeneration, KU Leuven Sophie De Mits Physical therapist, PhD, Dept. of Rehabilitation, Sciences and Physiotherapy, Ghent University & Artevelde University College; Dept. of Rheumatology, Ghent University Hospital Kevin Deschamps Podiatrist, PhD, Research Group for Musculoskeletal Rehabilitation, Dept. of Rehabilitation Sciences, KU Leuven; Parnasse-ISEI, Dept. of Podiatry, Brussels; Founding member BHPR vzw 12.00 General Assembly Belgian Health Professionals in Rheumatology vzw/asbl: Current projects and future perspectives (welcome to all) 12.20 Lunch Break 10 www.rheumacongress.be www.rheumacongress.be 11

Thursday, September 25 Meeting for Health Professionals in Rheumatology - Afternoon Organised by the Belgian Health Professionals in Rheumatology (BHPR) vzw/asbl 14.00 What s HOT for health professionals in rheumatology? Yvonne Van Eijk-Hustings 14.30 Case 2: Round table discussion across disciplines (French and Dutch) Marie Avaux Pauline Hoellinger, Occupational therapist, Department of Rheumatology, Université Catholique de Louvain, Founding member BHPR vzw Yvonne Van Eijk-Hustings 15.30 Coffee Break 15.45 Belgian health professional s research in short (3 topics, 10 min each) 16.15 Closing discussion: Future congress, where do we go from here? Marie Avaux, Thijs Swinnen *Free of charge: includes registration, coffee breaks, lunch and hand-outs **All sessions will be presented in English, but (round table) discussions and handouts for each session will be available in both Dutch and French Registration Registration Fees EARLY LATE Until August 31 As of September 1 Congress Members KBVR-SRBR 150,00 250,00 Non Members 250,00 350,00 Trainees in Rheumatology* 50,00 75,00 Other Trainees* 75,00 100,00 Researchers non-md* 50,00 75,00 Workshops** Free Free Health Professionals Meeting*** Free Free *Proof of student or trainee (PhD student) status is to be sent to Medicongress. Without this proof the Non Member fee will be charged. **Participation in the workshops is free of charge and is limited to 20 participants. ***Register via: thijs.swinnen@uzleuven.be The registration fee for participants includes Participation in all scientific sessions Participation in the quizzes and hands-on workshops (separate registration required, limited to 20 participants) Participation in the Updates in Therapeutics organised by the Industry Congress bag with the Programme and Abstracts, tourist info and congress related documents Access to the exhibition Lunches and coffee breaks How to register You can register online through the congress website www.rheumacongress.be. Click on Registration for details and access to the online registration form. When your registration is completed successfully, you will receive an automatic confirmation. You can also print an invoice when you finalise your online registration. Changes/Name Substitutions You will receive a personal link in your final confirmation email. With this link it will be possible to make changes or transfer your registration to a colleague free of charge. If you require the help of the congress secretariat, there will be a charge of 50,00 for name substitutions. Cancellations Participants canceling their registration before September 1, 2014, will receive a full refund, less 50,00 administration costs. There will be no refunds for cancellations received after this date. Cancellations must be confirmed in writing to the Organising Secretariat. All refunds will be processed after the Congress. 12 www.rheumacongress.be www.rheumacongress.be 13

Hotel Accommodation Hotel Pullman Brussels Midi has been selected as official congress hotel. A number of rooms have been booked at group rates. As hotel rooms in Brussels are quite expensive the KBVR-SRBR has decided to cover part of the hotel bill of KBVR-SRBR members staying at the congress hotel Pullman Brussels Midi. The rates at Hotel Pullman Brussels Midi are: For Non Members: Single Room: 179,00/night Double Room: 199,00/night City tax: 8,50 per room/night These rates include breakfast and VAT. For KBVR-SRBR Members: Single Room: 150,00/night Double Room: 170,00/night These rates include breakfast and VAT. To obtain the above rates, please make sure to follow this procedure: Book your room online (as part of the registration procedure) via the congress website: www.rheumacongress.be Prepay your hotel room for the entire stay during the registration procedure It is important to note that confirmed and prepaid rooms CANNOT be cancelled. A hotel confirmation will be sent by email after receipt of the registration form and housing request and payment of both. Rooms are booked on a first come, first served basis. Room availability cannot be guaranteed after August 31. General Information Venue The Wild Gallery 11 rue du Charroi / Gerijstraat 11 1190 Forest / Vorst Web: www.wildgallery.be Car Park A guarded car park will be available free of charge at 100 m from the Wild Gallery. Public Transport Brussels Midi train station is located at 25 minutes walking distance from the Wild Gallery. Access by tram: lines 82 and 99 Access by bus: lines 49 and 50 Accreditation A request for accreditation has been submitted to the RIZIV / INAMI. Exhibition A medical exhibition will be held on the occasion of the Congress. Access is free for registered participants. The exhibition is not accessible for non-mds. Liability Neither the organisers nor Medicongress accept liability for damages and/or losses of any kind which may be incurred by Congress participants during the Congress. Participants are advised to take out insurance against loss, accidents or damage which could be incurred during the Congress. Shuttle bus transport will be organised between Hotel Pullman Brussels Midi and the Wild Gallery. 14 www.rheumacongress.be www.rheumacongress.be 15

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