ONWAR 9th GRADUATE COURSE ON NEUROPSYCHOPHARMACOLOGY SEPTEMBER 3-10, 2015 1
PREFACE This 9 th graduate Neuropsychopharmacology course, designed for PhD students and postdocs in the field of neurosciences, is organized by the Graduate School Neurosciences Amsterdam Rotterdam, the Brain Center Rudolf Magnus (Utrecht) and the Centre for Human Drug Research (Leiden). The course addresses our current understanding of the pharmacology of CNS active drugs, the discovery of CNS drug targets as well as the development of innovative medicines and therapies, allowing students to become familiar with the fascinating field of neuropsychopharmacology. During the course, the major classes of pharmacotherapeuticals for the clinical management of various neurological and psychiatric diseases and the pathological mechanisms of these brain disorders will be discussed. Each day addresses a particular type of neurological or psychiatric disorder from basics to bedside. The program includes lectures, demonstrations, site visits and special lectures. The different topics of the course will be presented at different locations in Amsterdam, Utrecht and Leiden. Travel instructions and local maps are included in the reader. Attendance of all lectures is mandatory and will be honoured with a certificate. Accreditation covers 48 hours in the graduate teaching programs on neuroscience. If you are not able to attend a specific activity, please notify Taco de Vries (tj.devries@vumc.nl). We hope that you will appreciate this course, The organizing committee, Prof.dr. H.E. de Vries Prof.dr. T.J. de Vries (chair) Dr. B. Drukarch (co-chair) Dr. M.A.F.M. Gerrits Prof.dr. J. van Gerven Prof.dr. D.J. Veltman Prof.dr. W.J. Wadman Dr. M.M.M. Wilhelmus 2
PROGRAM Course on Neuropsychopharmacology September 3-10, 2015 Topics and places September 3 Impulsivity, compulsivity & addiction Amsterdam VUmc September 4 Affective disorders Amsterdam VUmc September 7 Question-based development Leiden CHDR of CNS-active drugs September 8 Psychotic disorders Utrecht UMCU September 9 Neurodegenerative disorders Amsterdam VUmc September 10 Epilepsy Amsterdam UvA 3
Thursday September 3, 2015, Amsterdam Room: VUmc, Building Medical Faculty, MF-H161 IMPULSIVITY, COMPULSIVITY & ADDICTION Coordinator: Prof.dr. T.J. de Vries 10.30 11.00 Coffee/Tea and Introduction Prof.dr. T.J. de Vries, VUmc, Amsterdam 11.00 11.45 OCD: novel treatment options. Dr. O.A. van den Heuvel, VUmc, Amsterdam 11.50 12.35 Psychopharmacology of ADHD. Dr. T. Pattij, VUmc, Amsterdam 12.35 13.15 Lunch (provided) 13.15 14.00 Addiction: a treatable brain disease. Prof.dr. W. van den Brink, AMC/UvA, Amsterdam 14.05 14.50 Identification of novel treatment targets in addiction. Prof.dr. T.J. de Vries, VUmc, Amsterdam 14.50 15.05 Coffee/Tea 15.05 16.00 Keynote lecture: Rational design of ligands for nicotinic acetylcholine receptors. Prof.dr. A.B. Smit, VU, Amsterdam 4
Friday September 4, 2015, Amsterdam Room: VUmc, Building Medical Faculty, MF-H161 AFFECTIVE DISORDERS Coordinator: Prof.dr. D.J. Veltman 09.00 09.45 Opening + Depression: clinical and neurobiological aspects Prof.dr. D.J. Veltman, VUmc, Amsterdam 09.45 10.30 Bipolar disorder Prof.dr. R. Kupka, VUmc, Amsterdam 10.30 10.50 Coffee/Tea 10.50 11.35 Animal models Prof.dr. S. Spijker, VU, Amsterdam 11.35 12.20 Molecular imaging in mood disorder Dr. E. Ruhé, UMCG, Groningen 5
Monday September 7, 2015, Leiden Centre for Human Drug Research QUESTION-BASED DEVELOPMENT OF CNS-ACTIVE DRUGS Coordinators: Prof.dr. J.M.A. van Gerven and Dr. G.J. Groeneveld 08.30-09.00 Welcome and coffee/tea 09.00-09.30 CNS drug development: from phases to questions Prof.dr. A.F. Cohen, CHDR, Leiden 09.30-10.30 What is the dose range for first-in-human administration? investigators brochure and animal-to-human predictions Prof.dr. J.M.A. van Gerven, CHDR, Leiden 10.30-11.00 Coffee/tea 11.00-11.45 Does the drug enter the central nervous system? pharmacokinetics and pharmacodynamics of BBB-penetration Dr. G.J. Groeneveld, CHDR, Leiden 11.45-12.30 Does the drug have its anticipated pharmacological effects? pharmacological biomarkers and challenge tests Prof.dr. J.M.A. van Gerven, CHDR, Leiden 12.30-13.45 Lunch (provided) 13.45-14.30 Does the drug have meaningful (patho)physiological effects? translational disease models and disease models Dr. G.J. Groeneveld, CHDR, Leiden 14.30-15.15 Case: Migraine - from genes to mouse model and drug target Prof.dr. M.D. Ferrari, Leiden 15:15 15:45 Coffee/tea 15:45-17.00 Laboratory visits NeuroCart and PainCart demonstrations 17:00-18.00 Drinks 6
Tuesday September 8, 2015, Utrecht University Medical Center Utrecht, Hijmans van den Bergh building, room HVDB - 3.70, Universiteitsweg 98, Utrecht PSYCHOTIC DISORDERS Coordinator: Dr. M.A.F.M. Gerrits 08.45 09.00 Coffee/tea 09.00 09.45 Antipsychotics: mechanism of action and pharmacological profiles Dr. T. Werkman, UvA, Amsterdam 10.00 10.45 Electroencephalography as a tool to improve antipsychotic medication Dr. B. Oranje, UMCU, Utrecht 11.00 11.45 Animal models for antipsychotic drug research Dr. L. Groenink, UU, Utrecht 12.00 13.00 Lunch (provided) 13.00 13.45 Gray and white matter density changes in schizophrenia Prof.dr. H. Hulshoff-Pol, UMCU, Utrecht 14.00 16.00 Site visit brain imaging Dr. N.E.M. van Haren, UMCU, Utrecht 7
Wednesday September 9, 2015, Amsterdam Room: VUmc, Building Medical Faculty, MF-H161 NEURODEGENERATIVE DISORDERS Coordinator: Prof.dr. H.E. de Vries 09.00 09.40 uur Introduction into MS Prof.dr. H.E. de Vries, VUmc, Amsterdam 09.40-10.45 uur MS pathologie Dr. J. van Horssen, VUmc, Amsterdam 10.45-11.00 uur Coffee/Tea 11.00-11.40 uur MS imaging Dr. M.M. Schoonheim, VUmc, Amsterdam 11.40 12.20 uur Impulsive control in PD Dr. C. Vriend, VUmc, Amsterdam 12.20 13.10 uur Lunch (provided) 13.10 13.50 uur Intro AD en ttg als therapie in AD Dr. M.M.M. Wilhelmus, VUmc, Amsterdam 13.50 14.30 uur UPR as therapy in AD Dr. W. Scheper, VUmc, Amsterdam 14.30 15.10 uur PET in AD therapy and diagnostics Dr. S. Adriaanse, VUmc, Amsterdam 15.10 15.30 uur Coffee/Tea 15.30 16.10 uur Inflammation as therapy in AD Dr. J. Hoozemans, VUmc, Amsterdam 8
Thursday September10, 2015, Amsterdam CWI, Eulerzaal, Science Park Amsterdam EPILSEPSY Coordinator: Prof.dr. W.J. Wadman 09:15 Reception with coffee 09:30 Epilepsy, Epileptogenesis and Experimental models Prof.dr. Fernando H Lopes da Silva (SILS-UvA) 10:30 coffee 10:45 Anti-Epileptic drugs: their interaction with sodium channels Prof.dr. Wytse J Wadman (SILS-UvA) 11:45 Epileptogenesis and the mtor pathway Dr. Erwin van Vliet (AMC, Amsterdam) 12:45 Lunch 14:00 Noradrenaline and epileptic seizures; a role in vagus stimulation? Prof.dr. Robrecht Raedt (AZG, Universiteit van Gent, Belgium) 15:00 Excitability in the brain, deep brain stimulation as treatment in epilepsy. Prof.dr. Wytse J Wadman (SILS-UvA) 16:00 Farewell drinks for the ONWAR course at the Science Park Amsterdam 9