Curriculum Vitae. João Pedro Martins de Almeida Lopes

João Pedro Martins de Almeida Lopes Feb 2014

João Pedro Martins de Almeida Lopes Index 1. Personal data... 4 1.1 Address... 4 1.1.1 Personal... 4 1.1.2 Institutional... 4 1.2 Contacts... 4 2. Academic background... 5 3. Professional activities... 6 4. Scientific specialization... 7 4.1 Keywords... 7 4.2 Scientific activity areas... 7 4.3 Current research interests... 7 5. Teaching activities... 8 5.1 Secondary school level... 8 5.2 Undergraduatelevel (BSc)... 8 5.3 Postgraduated level... 8 5.4 Courses and Workshops... 9 5.5 Member of thesis advisory committees... 10 6. Trainee periods and missions... 11 7. Supervision experience... 12 7.1 Undergraduate students... 12 7.2 Msc Thesis (2nd cycle)... 13 7.2.1 As supervisor... 13 7.2.2 As co-supervisor... 14 7.3 PhD Thesis (3rd cycle)... 14 7.3.1 As main supervisor... 14 7.3.2 As co-supervisor... 15 7.4 Postdoc level... 16 7.4.1 As supervisor... 16 7.4.2 As co-supervisor... 16 8. Research projects... 17 8.1 Coordination... 17 8.2 Participation... 18 9. Protocols with companies and associations... 20 10. Prizes and awards... 21 11. Publications... 22 11.1 Thesis... 22 Page 2

11.2. Book chapters... 22 11.3. Articles in peer-reviewed international scientific journals... 23 11.4 Articles in national scientific journals... 28 11.5 Reviews and Commentaries... 29 12. Communications... 30 12.1 International scientific conferences... 30 12.1.1 Proceedings in conference actas... 30 12.1.2 Invited lectures... 32 12.1.3 Regular oral communications (presented by João Lopes)... 34 12.1.4 Regular oral communications (presented by co-authors)... 36 12.1.5 Posters... 41 13. Academic activities... 53 13.1 Scientific collaborations... 53 13.1.1 International collaborations... 53 13.1.2 National collaborations... 54 13.2 Participation in thesis boards... 55 13.2.1 By invitation... 55 13.2.3 Own students... 57 13.3 Reviewing activities... 58 13.3.1 Scientific projects... 58 13.3.2 Scientific articles... 58 13.4 Editorial boards... 58 13.5 Conferences organization... 59 13.5.1 As Chairman... 59 13.5.3 As Member of the Organizing committee or Scientific board... 59 14. Organizations... 61 14.1 Steering committees and directive boards... 61 14.2 Membership... 61 15. Complementary informations... 62 15.1 Diplomes... 62 15.2 Languages... 62 15.3 Computer languages... 62 15.4 Additional informations... 63 Page 3

João Pedro Martins de Almeida Lopes 1. Personal data Name: Birth date: Nationality: Marital status: Professional category: Lisbon) João Pedro Martins de Almeida Lopes November 19 th, 1973 (Leiria, Portugal) Portuguese Married Assistant Professor (Faculty of Pharmacy of University of 1.1 Address 1.1.1 Personal Rua Fernando Barros Leal, 15, 1ºEsq, 2560-253, Torres Vedras, Portugal 1.1.2 Institutional Faculdade de Farmácia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal 1.2 Contacts Phone: +351 / +351 261 404 640 Mobile phone: +351926 652 582 Fax: +351 Email: Webpage: jlopes@ff.ul.pt http://chemometricsandpat.wordpress.com/ Researcher ID:H-1733-2011(http://www.researcherid.com/rid/H-1733-2011) ORCID:0000-0002-1657-344X Page 4

2. Academic background 1991-1997 BSc degree in Chemical Engineering with Biotechnology specialization(5 years course with a grade point average of 15 (on a 0-20 scale).(instituto Superior Técnico, Universidade Técnica de Lisboa) 1997-1999 Mobility grant(praxis XXI/BMCT/12353/96). Project Supervision, optimization and control of pharmaceutical processes supervised by Prof.José Cardoso Menezes (Instituto Superior Técnico, Universidade Técnica de Lisboa) 1999-2001 PhD studentin Chemical Engineeringwith a Thesis titled Supervision and diagnosis of pharmaceutical processes with intelligent data analysis methods (Instituto Superior Técnico, Universidade Técnica de Lisboa) 2002-2005 Post-Doc researcher in (Bio)Process Systems Engineering (Instituto Superior Técnico, Universidade Técnica de Lisboa) 2005-2013 Assistant Researcher of the Associated Laboratory REQUIMTE at the Faculty of Pharmacy of University of Porto 2014- Assistant Professor of the Faculty of Pharmacy of University of Lisbon (Galenic Pharmacy and Pharmaceutical Technology Department) Page 5

João Pedro Martins de Almeida Lopes 3. Professional activities 1996-1997Professor of Physical-chemical Sciences (Ciências Físico-Químicas)(8º, 9º and 10º years) (Escola Secundária de Raúl Proença, Caldas da Rainha) 1997 2001PhD student(cebq, Instituto Superior Técnico, Universidade Técnica de Lisboa) 2002-2005PostDoc researcher(cebq, Instituto Superior Técnico, Universidade Técnica de Lisboa) 2004 2006 Professorof Instrumental Methods of Analysis II(Métodos Instrumentais de Análise II) (Escola Superior de Biotecnologia, Universidade Católica Portuguesa) 2005 Head of the Analytical Methods Development section of the Department of Quality Control, SIDEFARMA S.A., Prior Velho, Portugal Dec 2005-2010Investigador Auxiliar of REQUIMTE (University of Porto) Since 2007Founder and Senior Consultant of WORLDMETRICSSOLUTIONS, Lisboa, Portugal (http://www.worldmetrics.net) 2010- Dec 2013 Investigador Auxiliar of REQUIMTE (Instituto de Ciências Agrárias e Agro-Alimentares of the University of Porto) Since Dec 2013 - Assistant Professor of the Faculty of Pharmacy of University of Lisbon (Galenic Pharmacy and Pharmaceutical Technology Department) Page 6

4. Scientific specialization 4.1 Keywords Chemometrics, Vibrational spectroscopy; Statistics, Pharmaceutical productionprocesses; Bioreactors modelling; Multivariate data analysis;near-infrared spectroscopy; Biospectroscopy; Process Analytical Technology (PAT); Quality-by- Design (QbD) 4.2 Scientific activity areas 1.Chemometrics (multivariate data analysis) 2.Biospectroscopy(near infrared spectroscopy, mid infrared spectroscopy) 3.Process Analytical Technology (PAT) - high-throughput monitoring 4. Biological engineering 5.Process Systems Engineering (PSE) 4.3Current research interests 1. In-situ/real-time biotechnology processes monitoring and control 2. Near-infrared and mid-infrared spectroscopy applications 2.Biological reactors (modeling, simulation and control) 3. Chemometrics applied to analytical chemistry and biological systems (multivariate data analysis, mathematical modeling, biosystems modeling, pattern recognition, spectral resolution, decision support systems) 4. Identification and classification of pathogenic bacteria by vibrational spectroscopy methods 5.Process quality control of pharmaceutical products with high-throughput spectroscopy methods 6. Environmental bioprocesses monitoring and modeling Page 7

João Pedro Martins de Almeida Lopes 5.Teaching activities 5.1 Secondary school level 1996/1997 Teacherof physical-chemical sciences (8º, 9º and 10º years) (Escola Secundária de Raúl Proença, Caldas da Rainha) 5.2 Undergraduatelevel (BSc) 2003/2004,2004/2005 Teaching supervisor of Bioprocesses Monitoring and Control (Monitorização e Controlo de Bioprocessos), 4th year of the Biological Engineering degree(instituto Superior Técnico, Universidade Técnica de Lisboa) 2003/2004, 2004/2005 Teaching supervisor of Process Supervision and Diagnosis (Supervisão e Diagnóstico de Processos), 4th year of the Chemical Engineering degree e(instituto Superior Técnico, Universidade Técnica de Lisboa) 2004/2005, 2005/2006 Professor of Instrumental Methods of Analysis II (Métodos Instrumentais de Análise II), 3rd year of the Microbiology degree(escola Superior de Biotecnologia, Universidade Católica Portuguesa) 2009/2010 Supervisor of Project I disciplinestudents of the 4th year (2 nd cycle) of the Pharmaceutical Sciences degree (Faculty of Pharmacy, University of Porto) 5.3 Postgraduated level 1998/1999 Teacher of the discipline Monitoring and Control and Optimization in Chemical Engineering. MSc course in Biotechnology,Instituto Superior Técnico, Universidade Técnica de Lisboa 1999/2000 Teacher of the discipline Modelling and Control of Biological Processes. MSc in Biotechnology, Instituto Superior Técnico, Universidade Técnica de Lisboa Page 8

2004/2005 Module of Strategy of Chemical Analysis and Experimental Design.MSc coursein Chemical Engineering Applied Chemistry,Instituto Superior Técnico, Universidade Técnica de Lisboa (24 hours) 2004/2005 Module Process Monitoring, Supervision and Diagnosis. Postgraduation course in Systems Engineering in Chemical Processes, Instituto Superior Técnico,Universidade Técnica de Lisboa (24 hours) 2004/2005, 2005/2006 Module of Spectroscopic Methods Systems for Microbial Diagnosis.Post-graduation course in Applied Microbiology, Escola Superior de Biotecnologia, Universidade Católica Portuguesa (8 hours) 2012 - Module of Green Monitoring Technologies, REQUIMTE PhD Program in Sustainable Chemistry Starting School, 23-27Jan2012 (FCT/UNL, Lisbon) (3 hours) 2013 - Module of Green Monitoring Technologies, REQUIMTE PhD Program in Sustainable Chemistry Starting School, 21-25Jan2013(FCT/UNL, Lisbon) (3 hours) 5.4Courses and Workshops 2003, 2004Workshop - Matlab, Chemical Engineering and Biological Engineering,Instituto Superior Técnico, Universidade Técnica de Lisboa (8 hours) 2005Course - Industrial Chemometrics,Chemical Engineering/Biological Engineering, Instituto Superior Técnico, Universidade Técnica de Lisboa (300 hours) 2009 Course - Process Analytical Technology- PAT-I,Merck Sharp&Dohme Corp., Darmstadt, Germany, April 2009 (21 hours) 2009 Course - Process Analytical Technology- PAT-II, Merck Sharp&Dohme Corp., Darmstadt, Germany, July 2009 (21 hours) 2010Workshop - Aplicação de Ferramentas quimiométricas à monitorização espectral in situ de biorreactores, Centro de Engenharia Biológica e Química do Instituto Superior Técnico, Universidade Técnica de Lisboa, 22/4 2010 (7 hours) Page 9

João Pedro Martins de Almeida Lopes 2010 Post-graduation course- Near-infrared spectroscopy, Chemistry Institute, UNESP, Araraquara, Brasil, 7/4-16/4 2010 (60 credits) 2010 Workshop - High-throughput microbial diagnosis tools.doctoral Program of Microbiology, IHMT/UNL, Lisbon, July 5 2010(6 hours) 2012 Summer Course - The Chemometrics Approach, Doctoral Program in Conservation and Restauration, Faculty of Sciences and Technology, Universidade Nova de Lisboa, Lisbon, September 3-7 2012 (30 hours) 5.5 Member of thesis advisory committees 1. Ornella Ewa Preisner, PhD in Biotechnology, Technical University of Lisbon, Title: Identification of pathogenic bacteria by Fourier-transform infrared (FT-IR) spectroscopy and chemometrics, 2007-2009. 2. Marta Félix Campos, Doctoral Program in Conservation and Restoration, New University of Lisbon, Scientific domain: Artistic studies. Title: Crossing borders: History, materials and techniques of Silva Porto and João Marques de Oliveira, started in 2012 3. Élia Roldão, Doctoral Program in Conservation and Restoration, New University of Lisbon, Scientific domain: Artistic studies. Title: Conservation of photographic films, started in 2012 4. Susana Belchior, Doctoral Program in Conservation and Restoration, New University of Lisbon, Scientific domain: Artistic studies. Title: Immaterial in the Material: a study on 78rpm audio carriers in Portuguese collections, started in 2013 Page 10

6. Trainee periods and missions March 1996 - September 1996 Curricular traineeship of Chemical Engineering (program ERASMUS) at the Faculty of Sciences of La Rochelle (La Rochelle, France) yielding a Thesis titled Extraction and Purification of an Hydrolytic Enzyme by Ion-Exchange Chromatography (6 months) November 1997 Trainee period at the Centre for Process Analysis and Chemometrics (CPAC), University of Newcastle upon Tyne (Newcastle, United Kingdom), supervised by Prof. Julian Morris with the topic Modelling of Antibiotic Fermentation Processes with Artificial Neural Networks) (15 days) January 1998- Trainee period at the Centre for Process Analysis and Chemometrics (CPAC), University of Newcastle upon Tyne (Newcastle, United Kingdom), supervised by Prof. Julian Morris with the topic Process Monitoring with Multivariate Statistical control Methods (15 days) September 2000 - October 2000 Trainee period at the Centre for Process Analysis & Chemometrics (PAC), University of Amsterdam (Amsterdam, The Netherlands), supervised by Prof. Age Smilde, with the topic Application of Multiblock PLS to industrial fermentation processes modeling (1 month) June 2005 Scientific mission to the Instituto de Desarrollo y Diseño (Santa Fé, Argentina) related with an international research cooperation project between Portugal and Argentina financed by GRICES-MCTES/SECYT (15 days) April 2010 Scientific mission to the Institute of Chemistry,UNESP (Araraquara, Brasil) related with an international research cooperation project between Portugal (FF/UP) and Brasil (IQ/UNESP) financed by FCT/CAPES (15 days) November 2010 Scientific mission to the Instituto de Desarrollo y Diseño (Santa Fé, Argentina) related with an international research cooperation project between Portugal and Argentina financed by FCT-MCTES/SECYT (15 days) April 2012 Invited to participate on the Euraxess meeting at the European Commission Round table to discuss the role of researchers within the European Union, 22-23 April 2012, Brussels, Belgium. Page 11

João Pedro Martins de Almeida Lopes 7. Supervision experience 7.1 Undergraduate students 1.8 curricular traineeships of senior students (5th year) of Chemical andbiological Engineering in Portuguese industrial companies (6 months duration)(instituto Superior Técnico, Universidade Técnica de Lisboa) (supervised by José Menezes, IST/UTL) 2.Ana Isabel de Vasconcelos Cruz(2008-2009) 1 year duration grant - FCT/BII Quality controlof pharmaceutical specialties with near infrared spectroscopy and chemometrics, Faculty of Pharmacy, University of Porto 3.Sandra Liliana de Oliveira Soares(2008-2009) 1 year duration grant - FCT/BII, Degradation studies of pharmaceutical products with near infrared spectroscopy, Faculty of Pharmacy, University of Porto 4.Sandra Liliana de Oliveira Soares (2009-2010) Project I-Master in Pharmaceutical Sciences degree- Characterization of pharmaceutical active ingredients polymorphic forms by near-infraredspectroscopy, Faculty of Pharmacy, University of Porto 5.Andreia Queirós (2009-2010) Project I- Master in Pharmaceutical Sciences degree - New approaches for estimating the post-mortem interval: Direct skin surface analysis using FTIRspectroscopy, Faculty of Pharmacy, University of Porto (Supervised by Agostinho Almeida, FF/UP) 6.Clara Cecília Santana Sousa (2009-2010) Project I- Masters in Pharmaceutical Sciences degree - Validação da espectroscopia de infravermelho, FTIR, na classificação de isolados do género acinetobacter, Faculty of Pharmacy, University of Porto(Supervised by Luís Peixe, FF/UP) 7.Lien Mahy (2011) Project II- Master in Pharmaceutical Sciences - Differentiation of Acinetobacter bacteria with intrinsic fluorescence spectroscopy,faculty of Pharmacy, University of Porto 8.Raquel Queiroz Portela Mendes de Figueiredo (2011) Unidade curricular de opção (Introdução ao Projecto) - Master in Industrial Pharmaceutical Chemistry, Optimization of the manufacturing process and quality control of solid dosage forms in the pharmaceutical industry with near-infrared spectroscopy and chemometrics, Faculty of Pharmacy, University of Coimbra Page 12

9. Annelies Dhaese (2012) Project II - Master in Pharmaceutical Sciences degree - High-throughput monitoring of co-crystals production, Faculty of Pharmacy, University of Porto (Feb 2012 - May 2012). 10. Rita Batista Matias (2013) MSc Seminar The role of Process Analytical Technology and Quality-by-Design in the context of Dissolution Testing.Master in Pharmaceuticals Quality Control and Medicinal Plants, Faculty of Pharmacy, University of Porto (discussed on April 10, 2013) 11. Valérie De Scheerder (2013) Project II - Master in Pharmaceutical Sciences degree - Discrimination of Klebsiella pneumonia clones using spectroscopic methods compared to molecular typing methods, Faculty of Pharmacy, University of Porto (Feb 2013 - May 2013). 7.2 MscThesis (2nd cycle) 7.2.1 As supervisor 1.Ricardo N.M.J. Páscoa, Monitorização In-Situ de Processos de Tratamento de Águas Residuais com Espectroscopia de Infra-Vermelhos Próximos, MSc thesis in Environmental Chemistry, Faculty of Pharmacy, University of Porto, December 6, 2006 (co-supervised by José Costa Lima, REQUIMTE, Faculty of Pharmacy, University of Porto) 2.Sandra Brogueira Lopes, Desenvolvimento acelerado de separações cromatográficas na industria farmacêutica com métodos quimiométricos, MSc thesis in Chemical Engineering-Applied Chemistry, Instituto Superior Técnico, Technical University fo Lisbon, May 18, 2007 (co-supervised by Teresa Duarte, IBB, Instituto Superior Técnico, Technical University of Lisbon) 3. Mónica Cancela de Abreu G.V. Almeida Miranda, Aplicação de espectroscopia de FTIR para a serotipagem e avaliação da susceptibilidade à penicilina em Streptococcus pneumoniae, MSc Thesis in Clinical Microbiology, Faculty of Medicine, University of Lisbon, May 14, 2008 (co-supervised by Mario Ramirez, Faculty of Medicine, University of Lisbon) 4. Lien Mahy, Intrinsic fluorescence spectroscopy for differentiating different acinetobacter species/subspecies using multivariate data analysis, MSc in Pharmaceutical Sciences, Faculty of Pharmacy, University of Ghent, June 1, 2011 (cosupervised by Thomas de Beer, Faculty of Pharmacy, University of Ghent). Page 13

João Pedro Martins de Almeida Lopes 5. Raquel de Queiroz Portela Mendes de Figueiredo, Manufacturing process and quality control of solid dosage forms optimization for the pharmaceutical industry by near infrared spectroscopy and chemometric analysis, MSc in Industrial Pharmaceutical Chemistry, Faculty of Pharmacy, University of Coimbra, September 24, 2012 (co-supervised by Jorge Ribeiro Salvador, Faculty of Pharmacy, University of Coimbra) (18 Valores) 6.Raquel Maria Tenório da Silva, High-throughput assessment of FTIR spectroscopy for morphological characterization of E.coli mutants, MSc in Pharmaceutical Engineering, Faculty of Pharmacy, University of Lisbon, October 8, 2012 (cosupervised by Isabel Portugal, Faculty of Pharmacy, University of Lisbon) (16 Valores) 7. Rita Batista Matias, In-situ drug dissolution tests monitoring with uv/vis/nir spectroscopy, MSc in Quality Control, Faculty of Pharmacy, University of Porto (since 2012) 7.2.2 As co-supervisor 1. Sandra Sofia Mota Rodrigues (completed), Modelização matemática do fenómeno de dispersão em sistemas de fluxo de interface única, MSc in Quality Control, Faculty of Pharmacy, University of Porto, July 23, 2009 (supervised by João L.M. Santos and co-supervised by José Costa Lima, Faculty of Pharmacy, University of Porto) 7.3 PhDThesis (3rd cycle) 7.3.1 Asmain supervisor 1. Mafalda S.C.C. Sarraguça (completed), Improved qualilty control of solid dosage forms for the pharmaceutical industry with high-throughput vibrational spectroscopy, PhD in Pharmaceutical Sciences, specialty of Analytical Chemistry, Faculty of Pharmacy, University of Porto, grant funded by FCT, Portugal(co-supervised by José Luís Costa Lima, REQUIMTE, Faculty of Pharmacy, University of Porto) (Dec 6, 2010) 2.Carla P.S. Coutinho(completed), Differentiation of clonal variants of the Burkholderia cepacia complex isolated during chronic respiratory infection in cystic fibrosis patients with FTIR spectroscopy, PhD in Pharmaceutical Sciences specialty Analytical Chemistry, Faculty of Pharmacy, University of Porto, grant funded by FCT, Portugal(co-supervised by Isabel Sá-Correia, IBB, Instituto Superior Técnico, Technical University of Lisbon) (Feb 25, 2011) Page 14

3.Ana Filipa Tavares Silva, Application of Process Analytical Technology and Quality-by-Design tools to pharmaceutical continuous manufacturing processes, PhD in Pharmaceutical Sciences, Faculty of Pharmacy, University of Porto and Faculty of Pharmacy of University of Ghent (co-supervised by Thomas de Beer, Faculty of Pharmacy, University of Ghent) (since 2012) 4.Miguel Pedro Estrada Lopo, Winemaking process advanced monitoring and control with high-throughput vibrational spectroscopy for the vinho verde wine industry: producing higher-valued wines and ensuring authenticity, PhD in Pharmaceutical Sciences-Analytical Chemistry, Faculty of Pharmacy, University of Port, grant funded by FCT, Portugal o (since 2012) 5.Cláudia Andreia Teixeira dos Santos, Oenological grapes potential: early control of grapes ripening towards the production of high-valued wines, PhD in Pharmaceutical Sciences-Analytical Chemistry, Faculty of Pharmacy, University of Porto, grant funded by FCT, Portugal (since 2012) 7.3.2 As co-supervisor 1.Ornella E. Preisner (completed), Identification of pathogenic bacteria by Fouriertransform infrared (FT-IR) spectroscopy and chemometrics, PhD in Biotechnology, Instituto Superior Técnico, Universidade Técnica de Lisboa (supervised by José Cardoso de Menezes, IBB, Instituto Superior Técnico, Technical University of Lisbon) (Sep 17, 2009) 2.Catarina P. Miguel (completed), The green and red: the colors of the Portuguese flag (green and red, the colors of Portugal), PhD in Conservation Studies, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, grant funded by FCT, Portugal (supervised by Maria João Melo, REQUIMTE, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa) (Dec 17, 2012) 3.Susana M. M. A. Lopes, Temas de carreira em sociedades de advogados: o contributo da adaptabilidade e dos factores cognitivos na identificação dos talentos. Um estudo internacional, PhD in Psychology, Faculdade de Psicologia e Ciências da Educação, Universidade de Lisboa (supervised by Maria Assunção, Faculdade de Psicologia e Ciências da Educação, Universidade de Lisboa) (since 2011) 4. Bjorn-Hendrik Peters, Impactof protein production method parameters on the quality of lyophilized proucts, PhD in Pharmaceutical Technology, Faculty of Health Sciences, University of Eastern Finland (supervised by Jarkko Ketolainen, Faculty of Health Sciences, University of Eastern Finland) (since 2012) Page 15

João Pedro Martins de Almeida Lopes 5. João Botelho, High-throughput FTIR spectroscopy methodologies for bacteria screening, PhD in Pharmaceutical Sciences-Microbiology, Faculty of Pharmacy, University of Porto, Portugal (supervised by Clara Sousa, Faculty of Pharmacy, University of Porto (since 2012) 7.4 Postdoc level 7.4.1 As supervisor 1.Jorge Miguel Gonçalves Sarraguça, Mathematical modeling framework of flow analysis methods for chemical, biochemical and pharmaceutical applications, Faculty of Pharmacy, University of Porto, grant funded by FCT, Portugal(co-supervised by José Luís Costa Lima and João L.M. Santos, Faculty of Pharmacy, University of Porto) (started Apr 1, 2009) 2.Mafalda Cruz Coelho Sarraguça, High-throughput spectroscopic characterization of solid forms and cocrystals: improving pharmaceutical manufacturing and enhancing pharmacological properties, Faculty of Pharmacy, University of Porto, grant funded by FCT, Portugal (started Jan 1, 2011) 3.Ricardo N.M.J.Páscoa, Non-invasive near-infrared spectroscopic technology for early prediction and optimization of wine quality, Faculty of Pharmacy, University of Porto, grant funded by FCT, Portugal (startedjan 1, 2012) 4. Paulo Roberto da Silva Ribeiro, High-performance analytical methods for the spectroscopic characterization of pharmaceutical solid forms, polymorphs and cocrystals of antihypertensive drugs,faculty of Pharmacy, University of Porto, grant funded by FAPEMA, Brazil (started March 2013). 7.4.2 As co-supervisor 1.Clara Cecília Santana Sousa, Genotypic and high-throughput methodologies for tracing the emerging pathogen Escherichia albertii, Faculty of Pharmacy, University of Porto, grant funded by FCT, Portugal (supervised by Luísa Peixe, Faculty of Pharmacy, University of Porto) (startedjul 1, 2011) Page 16

8. Research projects 8.1 Coordination January 2002 September 2002 - Coordination of an applied project financed by Biotecnol S.A. (Oeiras, Portugal) titled Design and implementation of an integrated platform of laboratorial control systems to manage fermentation processes (EUR6,000.00) 2003 Execution of a project financed by the Department of Process Controlof GALP ENERGIA S.A. (Sines, Portugal) for the implementation of an on-line supervision system of the main distillation column crude heaters (6 months duration) (EUR57,000.00) 2004 Coordinator of the participation of Technical University of Lisbon and 3 Portuguese industrial companies in the proposal process of an European project (Framework 6) SAFEPARK Safety of chemical parks (Total fundingeur10,000,000) (project not approved for funding by the European Commission) 2005-2007 Research Project financed by GRICES/SECYT in partnership with Prof. Ernesto Martinez (INGAR, Santa Fé, Argentina) (EUR4,000.00) Integration of chemometrics methods in the re-inforcement learning for monitoring and supervision of pharmaceutical bioprocesses) (2 years duration) 2007-2008 Scientific research project financed by the University of Porto (Reitoria- UP, CGD) at the pre-graduation level (EUR4,000.00) IPG131 Advanced control of pharmaceutical specialties with near-infrared spectroscopy and chemometrics (1 year duration) 2007-2009 - Research Project financed by the Associated Laboratory REQUIMTE (EUR18,000.00) REQMON - Monitoring, Optimization and Control of PHA Production by Mixed Microbial Cultures Based on Vibrational Spectroscopy (1 year duration) Since 2008 Coordination of a joint project between ICETA and BIAL S.A. (São Mamede do Coronado, Portugal) for the development of near-infrared methods for quality control of solid dosage oral forms 2010-2012 - Coordinator of the project "Decision support methodology for fast scaling and experimental optimization of innovative bioprocesses using tendency Page 17

João Pedro Martins de Almeida Lopes models and chemometrics".project type: Acordo de Cooperação Científica Portugal/Argentina (2 years duration, 7,200.00EUR) 2012 - Pluridisciplinar Projects IJUP2011/category SOGRAPE, Reference PP- IJUP2011-SOGRAPE- 347, High-throughput near-infrared spectroscopy based technology for qualifying grapes based on soil and climate conditions (3,500.00EUR/1 year duration). Funded by SOGRAPE. 8.2 Participation 1997-1999 Project financed by ADI (Agência de Inovação - ADI, program PRAXIS XXI Medida 3.1.b) between IST and CIPAN S.A. (ref a.l009-p31b-09/96, ADI- PRAXIS XXI) titled FASTERPROD Accelerated development of fermentation processes (coordinated by Prof José Menezes, IST/UTL, 3 years duration, EUR612,898.00) 1998-2000 Collaborator of the research project in consortium between IST and CIPAN S.A. (PRAXIS XXI Medida 3.1.b) titled OPTIMIF On-line optimization of industrial fermentations (ref a.l088-p31b-09/97) (coordinated byprof. Sebastião Alves, IST/UTL, 3 years duration, EUR312,000.00) 2000-2003- Collaborator of the research project financed by the SAPIENS/FCT program titled HYBRIDOMA Combination of mechanistic and empirical approaches for operating data analysis (coordinated by Prof. Pedro Andrade Saraiva, FC/UC, 3 years duration, EUR26,603.00) 2002-2004 - Participation in the research Project in consortium between IST and CIPAN S.A.financed by ADI (POCTI) titled IN-PROCESS - Improvement of Industrial Antibiotic Production Processes with Advanced In-Process Monitoring Techniques (coordinated by Prof. José Cardoso Menezes, IST/UTL,3 years duration, EUR213,000.00) 2003 Execution of a project financed by Tecnimede S.A. for the analysis of chromatographic data of pharmaceuticals for counterfeit drug control (3 months) 2005 Participation in a project financed by Tecnimede S.A. for the classification of molecular species in solid dosage oral forms by near-infrared spectroscopy (4 months) Page 18

2005 Execution of a project financed by the Department of Process Controlof GALP ENERGIA S.A. (Sines, Portugal) for the development of inferential sensors for the Visbreaker unit (3 months duration) (EUR 12,000.00) 2007-2009 - Responsible for ICETA participation in the research Project financed by Fundação para Ciência e Tecnologia (FCT) titled "The identity of portuguese medieval manuscript illumination in the european context" (PTDC/EAT/65445/2006)(coordinated bymaria João Melo, FCT/UNL, 2 years duration, EUR141,084.00) 2010-2012 - Responsible for ICETA participation in the research Project financed by Fundação para Ciência e Tecnologia (FCT) titled "Beleza e significado da cor na iluminura medieval Portuguesa." (PTDC/EAT-EAT/104930/2008) (coordinated by Maria João Melo, FCT/UNL, 2 years duration, EUR199,894.00) 2010-2013 - Responsible for ICETA participation in the research Project financed by Fundação para Ciência e Tecnologia (FCT) titled "Unveiling the secrets of Molecules with Colour and History: from Ancient to Modern times. A (Photo)chemical Approach." (PTDC/QUI-QUI/099388/2008) (coordinated by Sérgio Seixas de Melo, FCT/UNL, 3 years duration, EUR199,540.00) 2010-2012- Participant in the Research Executive Agency (Unit P1 Marie Curie Lifelong Training) FP7-PEOPLE-2009-IEF - 255512 - ECOCHAR - Characterization of widespread uropathogenic multidrug resistant Escherichiacoli clones by using a combined approach of conventional genotypic methods and high-throughputtechnology. Supervision of Dr Ângela Patrícia Amorim (coordinated by Luísa Peixe, Faculty of Pharmacy, University of Porto) 2011-2014 - Responsible for ICETA participation in the research Project financed by Fundação para Ciência e Tecnologia (FCT) titled "BIOTEXTILE - Biotecnologia de reactores descontínuos-sequenciais para o tratamento eficaz de águas residuais têxteis" (PTDC/EBB-EBI/120624/2010) (coordinated by Nídia Lourenço, IST/UTL, 3 years duration, EUR176,440.00) 2013 - Research Project financed by Fundação para Ciência e Tecnologia (FCT) titled "Validation and optimization of MALDI-TOF for identification and tracking of clinically relevant Escherichia coli clones and antibioticresistance mechanisms: a translational approach" (EXPL/DTP-EPI/0196/2012) (coordinated by Ângela Novais, REQUIMTE/ICETA, 1 year duration, EUR34,100.00) Page 19

João Pedro Martins de Almeida Lopes 9. Protocols with companies and associations 2008 Responsible for the collaboration protocol between ICETA (Instituto de Ciências Agrárias e Agro-Alimentares) and BIAL S.A., regulating the scientific partnership in the area of quality control of pharmaceutical specialties with nearinfrared spectroscopy (signed on January 2008) 2009 Responsible for the collaboration protocol between ICETA (Instituto de Ciências Agrárias e Agro-alimentares) and Casa Agrícola Alexandre Relvas LDA, regulating the scientific partnership in the area of PAT for the wine industry(signed on October 2009) 2009 Agreement between SOFARIMEX SA and ICETA (Instituto de Ciências Agrárias e Agro-alimentares)for the submission of aqren project (32/SI/2009) 2012 Coordinator of the protocol between ICETA (Instituto de Ciências Agrárias e Agro-alimentares) and SOGRAPE SA, regulating the scientific partnership in the area of modelling de impact of climatic and soil properties on grapes quality (signed in 2012) 2012 Collaboration between ICETA (Instituto de Ciências Agrárias e Agroalimentares) and ADVID (Associação para o Desenvolvimento da Viticultura Duriense) regulating the scientific partnership in the area of vineyards qualification. 2013 Collaboration protocol between ICETA (Instituto de Ciências Agrárias e Agroalimentares) and Comissão de Viticultura da Região dos Vinhos Verdes (CVRVV), regulating the scientific partnership in the area of quality control of red and white wines. Page 20

10. Prizes and awards 2003 -CUF Award Award assignedby CUF (Companhia União Fabril) and FCT (Fundação para a Ciência e Tecnologia) to the best Portuguese PhD Thesis in Chemical Engineering with industrial application produced between 1999 and 2001 (Honorable mention, EUR1.000,00 prize) 2004- Bioempreendedor 2004 Award - Award assigned by ICEP(Instituto das Empresas para os Mercados Externos) and APBio (Associação Portuguesa de Biotecnologia)to the best entrepreneurship project in the biotechnology area (Winner, EUR5.000,00prize) 2012 Young Scientist Paper Award (First Place) - Awardedto Nídia Lourenço at the 6 th International Conference on Environmental Science and Technology 2012 for the communication Real Time Monitoring of a Sequencing Batch Reactor with In-Situ NIR Spectroscopy (authors: Nídia Lourenço, Cláudio Fernandes, João Almeida Lopes and Helena Pinheiro). Page 21

João Pedro Martins de Almeida Lopes 11. Publications 11.1 Thesis João A. Lopes (1996) Extraction and Purification of an Hydrolytic Enzyme by Ion- Exchange Chromatography ( Extraction et Purification d un Enzyme Hydrolitique ), ERASMUS monograph, Faculty of Sciences, University of La Rochelle, La Rochelle, France,September 1996 (ERASMUS program supervisedby Prof. Michel Goldberg) João A. Lopes (2001) Supervision and diagnosis of pharmaceutical processes with intelligent data analysis methods ( Supervisão e diagnóstico de processos farmacêuticos com métodos inteligentes de análise de dados ), PhD Thesis, Instituto Superior Técnico, Universidade Técnica de Lisboa, October 2001, Lisboa, Portugal (PhD supervisedby Prof. José Cardoso Menezes) 11.2. Book chapters 3. Andrea Catalina Galvis-Sánchez, João Almeida Lopes, Ivonne Delgadillo and António O.S.S. Rangel. Chapter 26: Sea salt, page 719. In: Comprehensive analytical chemistry, Vol. 60. Food Protected designation of origin: methodologies and applications. Edited by Miguel de la Guardia M and Ana Gonzalvez, Elsevier, UK. 2013. (ISBN: 978-0-444-59562-1). 2. Clara C. Sousa and João A. Lopes. Chapter 20: Infrared spectroscopy detection coupled to chemometrics to characterize foodborne pathogens at a subspecies level, page 385. In: Mathematical and Statistical Approaches in Food Science and Technology. Edited by Daniel Granato and Gáston Ares,IFT Press - Wiley- Blackwell.UK. 2014. (ISBN: 978-1-118-43368-3) 1. Sarraguça M.C., Santos J.R., Magalhães L.M., Rangel A.O.S.S., Lopes J.A. Chapter X:Use of near infrared spectroscopy for coffee beans quality assessment, pag. XX. In: Coffee in Health and Disease Prevention. Edited by Victor R. Preedy, Elsevier, Amsterdam. 2013 (in-print) Page 22

11.3. Articles in peer-reviewedinternational scientific journals) 53. Clara Sousa, Liliana Silva, Filipa Grosso, João P. Lopes, Luísa Peixe, Development of a FTIR-ATR based model for typing clinically relevant Acinetobacter baumannii clones belonging to ST98, ST103, ST208 and ST218, Journal of Photochemistry and Photobiology B: Biology, in-print 52. R. Matias, P.R. Ribeiro, M. C. Sarraguça, J. A. Lopes, A UV spectrophotometric method for the determination of folic acid in pharmaceutical tablets and dissolution tests, Analytical Methods, in-print 51. Sousa C, Silva L, Grosso F, Nemec A, Lopes J, Peixe L. Discrimination of the Acinetobacter calcoaceticus-acinetobacter baumannii complex species by Fourier Transform Infrared Spectroscopy, European Journal of Clinical Microbiology and Infectious Diseases, in-print 50. Susana A Lopes,Jorge MG Sarraguça: João A Lopes Maria E Duarte, A new approach to talent management in law firms: integrating performance appraisal and assessment center data, International Journal of Productivity and Performance Management, in.print 49. Ângela Novais, Clara Sousa, Juan de Caballero, Ana Fernandez-Olmos, João Lopes, Maria Helena Ramos, Teresa M Coque, Rafael Cantón, Luísa Peixe, MALDI-TOF mass spectrometry as a tool for discrimination of high-risk Escherichia coli clones from phylogenetic groups B2 (ST131) and D (ST69, ST405, ST393), European Journal of Clinical Microbiology & Infectious Diseases, in-print.48. Saraiva R, Lopes JA, Feio MJ, Gameiro P*, Discrimination of single-porin Escherichia (E.) coli mutants by ATR and transmission mode FTIR spectroscopy, J. Biophotonics, in-print [doi: 10.1002/jbio.201200131] 47. Sousa CCS, Grosso F, Meirinhos-Soares L, Peixe L, Lopes JA*, Identification of carbapenem-resistant A. baumannii clones using infrared spectroscopy, J. Biophotonics, in-print [doi: 10.1002/jbio.201200075] 46. Couto M.C.M., Pinto I., Madureira T.V., Rocha M.J., Tiritan M.E., Lopes J.A. and Almeida A.A. (2014), Lower Douro river basin (Portugal) water quality Focus on trace element changes and anthropogenic sources of contamination, Global NEST Journal,16(2), 251-267 45. Clara Sousa, Ângela Novais, Ana Magalhães, João Lopes, and Luisa Peixe, Diverse high-risk B2 and D Escherichia coli clones depicted by Fourier Page 23

João Pedro Martins de Almeida Lopes Transform Infrared Spectroscopy (2013), Sci. Rep., 3, 3278 [doi:10.1038/srep03278] 44. A.F.T. Silva, A. Burggraeve, Q. Denon, P. Van der Meeren, N. Sandler, T. Van Den Kerkhof, M. Hellings, C. Vervaet, J.P. Remon, J.A. Lopes, T. De Beer (2013) Particle sizing measurements in pharmaceutical applications: comparison of inprocess methods versus offline methods, Eur. J. Pharm. Biopharm., 85, 1006-1018 [doi: 10.1016/j.ejpb.2013.03.032] 43. C. A. Teixeira dos Santos, M. Lopo, R.N.M.J. Páscoa, J.A. Lopes* (2013) A review on the applications of portable near infrared spectrometers in the agro-food industry, Appl. Spectrosc., 67(11), 1215-1233. [doi:10.1366/13-07228] 42. Ana Serrano, Micaela Sousa, Jessica Hallett, Monique S. J. Simmonds, Mark Nesbitt, and João A. Lopes* (2013) Identification of Dactylopius cochineal species with high-performance liquid chromatography and multivariate data analysis, Analyst, 2013, 138 (20), 6081-6090 [doi:10.1039/c3an00052d] 41. Sarraguça MC, Santos JR, Rangel AOSS, Lopes JA* (2013) Authenticity control of roasted coffee brands with near infrared spectroscopy, Food Anal. Met., 6(3),892-899 [doi:10.1007/s12161-012-9499-y] 40. Vaz MM, Meirinhos-Soares, Sousa CCS, Ramirez M, Melo-Cristino J, Lopes JA* (2013) Serotypes discrimination of encapsulated Streptococcus pneumoniae strains by Fourier-transform infrared spectroscopy and chemometrics, J. Microbiol. Met., 93, 102-107 [doi:10.1016/j.mimet.2013.02.008] 39. Galvis-Sánchez AC, Santos IC, Mesquita RBR, Lopes JA, Rangel AOSS, Delgadillo I* (2013) Application of Mid- and Near-Infrared Spectroscopy for the Control and Chemical Evaluation of Brine Solutions and Traditional Sea Salts, Food Anal. Met., 6, 470-480 [doi: 10.1007/s12161-012-9458-7] 38. Páscoa RNMJ, Magalhães LM, Lopes JA* (2013) FT-NIR spectroscopy as a tool for valorization of spent coffee grounds: application to assessment of antioxidant properties, Food Res. Int., 55, 579-586 [doi:10.1016/j.foodres.2013.01.035] 37. Miguel CP, Lopes JA*, Clarke M, Melo MJ (2012) Combining infrared spectroscopy with chemomeric analysis for the characterization of proteinaceous binders in medieval paints, Chemom. Intell. Lab. Syst., 119, 32-38 [doi:10.1016/j.chemolab.2012.09.003] 36. Aksu B, De Beer T, Folestad S, Ketolainen J, Lindén H, Lopes JA, de Matas M, Oostra W, Rantanen J, Weimer M (2012) Strategic funding priorities in the pharmaceutical sciences allied to Quality by Design (QbD) and Process Page 24

Analytical Technology (PAT), Eur. J. Pharma. Sci., 47, 402-405 [doi: 10.1016/j.ejps.2012.06.009] 35. Santos JR, Sarraguça MC, Rangel AOSS, Lopes JA* (2012) Evaluation of green coffee quality using NIR spectroscopy: a quantitative approach, Food Chem., 135, 1828-1835 [doi:10.1016/j.foodchem.2012.06.059] 34. Lourenço ND, Lopes JA, Almeida CF, Sarraguça MC, Pinheiro HM* (2012) Bioreactor monitoring with spectroscopy and chemometrics: a review, Anal. Bioanal. Chem., 404, 1211-1237 [doi:10.1007/s00216-012-6073-9] 33. Ribeiro DSM, Lopes JA, Santos JLM, Prior JAV* (2012) Exploiting adsorption and desorption at solid-liquid interface for the fluorometric monitoring of glibenclamide in adulterated drinks, Anal. Chim.Acta, 721, 97-103 [doi:10.1016/j.aca.2012.01.043] 32.Lopes SB, Sarraguça JMG, Prior JAV, Lopes JA* (2012) Development of an HPLC assay methodology for a desonide cream with chemometrics assisted optimization, Anal. Lett., 45(11), 1390-1400 [10.1080/00032719.2012.675494] 31. Sarraguça JMG*, Lopes JA, Santos JLM, Lima JLFC (2012) Mathematical simulation of signal profiles in flow analysis, Anal.Lett., 45(1), 85-98 [doi:10.1080/00032719.2011.582551] 30.Preisner OE, Menezes JC, Guiomar R, Machado J, Lopes JA* (2012) Discrimination of Salmonella enterica serotypes by Fourier transform infrared spectroscopy, Food Res. Int., 45(2), 1058-1064 [doi:10.1016/j.foodres.2011.02.029] 29.Galvis-Sánchez AC*, Lopes JA, Delgadillo I, Rangel AOSS (2011) Fourier-transform near-infrared spectroscopy application for sea salt quality evaluation, J. Agric. Food Chem., 59(10), 11109-11116 [doi:10.1021/jf202204d] 28.Serrano A, Sousa MM*, Hallett J, Lopes JA, Oliveira C (2011)Analysis of natural red dyes (cochineal) in textiles of historical importance using HPLC and multivariate data analysis, Anal. Bioanal. Chem., 401, 735-743 [doi:10.1007/s00216-011-5094-0] 27. Sarraguça MC, Lopes JA* (2011) A near-infrared spectroscopy method to determine aminoglycosides in pharmaceutical formulations, Vib. Spectrosc., 56, 184-192 [doi:10.1016/j.vibspec.2011.02.007] 26.Sarraguça MC, Cruz AV, Amaral HR, Costa PC, Lopes JA* (2011) Comparison of different chemometric and analytical methods for the prediction of particle size distribution in pharmaceutical powders, Anal.Bioanal. Chem., 399, 2137-2147 [doi:10.1007/s00216-010-4230-6] Page 25

João Pedro Martins de Almeida Lopes 25. Sarraguça MC, De Beer T, Verdaet C, Remon J, Lopes JA* (2010) A Batch Modelling Approach to Monitor a Freeze-Drying Process Using In-Line Raman Spectroscopy, Talanta, 83(1), 130-138[doi:10.1016/j.talanta.2010.08.051] 24.Preisner OE, Guiomar R, Machado J, Menezes JC and Lopes JA* (2010) Application of Fourier transform infrared spectroscopy and chemometrics for differentiation of Salmonella enterica Serovar Enteritidis phage types, Appl. Environ. Microbiol., 76(11), 3538 3544 [doi:10.1128/aem.01589-09] 23.Sarraguça MC, Cruz A, Soares S, Costa PC, Amaral HR, Lopes JA* (2010) Determination of flow properties of pharmaceutical powders by near infrared spectroscopy, J. Pharm. Biomed. Anal., 52, 484-492 [doi:10.1016/j.jpba.2010.01.038] 22.Rodrigues SM, Marques KL, Lopes JA*, Santos JLM, Lima JLFC (2010) Mathematical Modeling of Dispersion in Single Interface Flow Analysis, Anal. Chim. Acta, 663, 178-183 [doi:10.1016/j.aca.2010.01.051] 21. Sarraguça MC, Paulo A, Alves MM, Dias AMA, Lopes JA, Ferreira EC* (2009) Quantitative monitoring of an activate sludge reactor using on-line UV-visible and near infrared spectroscopy, Anal.Bioanal. Chem., 395, 1159-1166[doi:10.1007/s00216-009-3042-z] 20. Pires AR, Araújo AN, Lopes JA, Montenegro MCBSM* (2009)Simultaneous Potentiometric Determination of Thiamine and Pyridoxine in Multivitamins Using a Single Cyclodextrin-Based Thiamine-Selective Electrode, Anal. Lett., 42, 1923-1939 [doi:10.1080/00032710903082549] 19. Coutinho CP, Sá-Correia I, Lopes JA* (2009)Use of Fourier-transform infrared spectroscopy and chemometrics todiscriminate clinical isolates of Burkholderia cepacia complex bacteria fromdifferent species and ribopatterns, Anal. Bioanal. Chem., 394(8), 2161-2171[doi:10.1007/s00216-009-2908-4] 18. Ribeiro DSM, Prior JAV*, Lopes JA, Santos JLM, Lima JLFC (2009) Exploiting the Oxidative Coupling Reaction of MBTH for Indapamide Determination, Talanta, 79, 1161-1168 [doi:10.1016/j.talanta.2009.02.052] 17.Gaspar F, Lopes JA, Cruz H, Schwanninger M*, RodriguesJ (2009) Application of near infrared spectroscopy and multivariate data analysis for the evaluation of glue lines of untreated and copper azole treated laminated timber before and after ageing, Polym. Degrad.Stabil., 94, 1061-1071 [doi:10.1016/j.polymdegradstab.2009.04.011] Page 26

16.Sarraguça MC, Lopes JA* (2009) The use of net analyte signal (NAS) in NIR spectroscopy: interpretability and figures of merit, Anal. Chim. Acta, 642, 179-185 [doi:10.1016/j.aca.2008.10.006] 15.Sarraguça MC, Lopes JA* (2009) Quality Control of Pharmaceuticals with NIR: From Lab to Process Line, Vib.Spectrosc., 49(2), 204-210 [doi:10.1016/j.vibspec.2008.07.013] 14. Sousa MM, Melo MJ*, Parola AJ, Melo JSS, Catarino F, Pina F, Cook F, Simmonds MSJ, Lopes JA (2008) Flavylium chromophores as species markers for Dragon's blood resins from Dracaena and Daemonorops trees, J. Chrom. A, 1209, 153-161 [doi:10.1016/j.chroma.2008.09.007] 13. Páscoa R, Lopes JA*, Lima JLFC (2008) In situ near infrared monitoring of activated dairy sludge wastewater treatment processes, J. Near Infrared Spec., 16(4), 409-419 [doi:10.1255/jnirs.803] 12. Preisner OE*, Lopes JA, Guiomar R, Machado J, Menezes JC (2008) Uncertainty assessment in FT-IR spectroscopy based bacteria classification models, Chemom. Intell. Lab. Syst., 94(1), 33-42 [doi:10.1016/j.chemolab.2008.06.005] 11.Marques KL*, Santos JLM, Lopes JA, Lima JLFC (2008) Simultaneous chemiluminometric determination of levodopa and benserazide in a multipumping flow system with multivariate calibration, Anal. Sci., 24(8), 985-991 [doi:10.2116/analsci.24.985] 10. Ribeiro JPN, Lopes JA, Fachini A* (2008) Cleansing contaminated seawaters using marine cyanobacteria: evaluation of the trace metal removal from the medium, Intern. J. Environ. Anal. Chem., 88(10), 701-710 [doi:10.1080/03067310802061629] 9. Dias AMA*, Moita I, Alves MM, Ferreira EC, Páscoa R, Lopes JA (2008) Activated sludge process monitoring through in-situ near-infrared spectral analysis, Water Sci. Technol., 57(10), 1643-1650 [doi:10.2166/wst.2008.147] 8. Preisner OE*, Lopes JA, Giomar R, Machado J, Menezes JC (2007) Fourier transform infrared (FT-IR) spectroscopy in bacteriology: towards a reference method for bacteria discrimination, Anal. Bioanal. Chem., 387, 1739-1748 [doi:10.1007/s00216-006-0851-1] Page 27

João Pedro Martins de Almeida Lopes 7. Ferreira AP*, Lopes JA, Menezes JC (2007) Study of the application of multiway multivariate techniques to model data from an industrial fermentation process, Anal. Chim.Acta, 595(1-2),120-127 [doi:10.1016/j.aca.2007.05.007] 6. Brás LP*, Bernardino SA, Lopes JA, Menezes JC (2005) Multiblock PLS as an approach to compare and combine NIR and MIR spectra in calibrations of soybean flour, Chemom. Intell. Lab Syst., 75(1), 91-99 [doi:10.1016/j.chemolab.2004.05.007] 5. Felício CC, Brás LP, Lopes JA, Cabrita L, Menezes JC*(2005) Comparison of PLS algorithms in gasoline and gas oil parameters monitoring with MIR and NIR, Chemom. Intell. Lab. Syst., 78(1-2), 74-80 [doi:10.1016/j.chemolab.2004.12.009] 4. Lopes JA, Costa PF, Alves TP, Menezes JC*(2004) Chemometrics in bioprocess engineering: process analytical technologies (PAT) applications, Chemom. Intell. Lab Syst., 74, 269-275 [doi:10.1016/j.chemolab.2004.07.006] 3. Lopes JA*, Menezes JC (2004) Multivariate Monitoring of Fermentation Processes with Non-Linear Methods, Anal. Chim. Acta, 515(1), 101-108 [doi:10.1016/j.aca.2004.01.060] 2. Lopes JA*, Menezes JC (2003). Industrial Fermentation End-Product Modelling With Multilinear PLS, Chemom.Intell. Lab. Syst., 68(1-2), 75-81 [doi: 10.1016/S0169-7439(03)00089-3] 1. Lopes JA*, Menezes JC, Westerhuis JA, Smilde AK (2002). Multiblock PLS Analysis of an Industrial Pharmaceutical Process, Biotechnology and Bioengineering, 80(4), 419-427 [doi:10.1002/bit.10382] (*) corresponding author 11.4Articles in national scientific journals 4. Maria J. Melo, Adelaide Miranda, Catarina P. Miguel, Ana Lemos, Ana Claro, Rita Castro, Solange F. Muralha, João A. Lopes, Anónio P. Gonçalves (2011) The colour of medieval Portuguese illumination: an interdisciplinary approach, Revista de História da Arte, Série W, Nº1, 147-175 3.Lopes, J.A., Menezes, J. (2005) Process Analytical Technologies (PAT): aplicações na indústria química, farmacêutica e petroquímica, Robótica, 59, 28-32 Page 28

2.Menezes J., Lopes J.A., Rodrigues L., Ferreira A. (2006) Aplicações da Tecnologia Analítica de Processos (PAT) - Parte I de III, Controle de Contaminação, 82, 18-22 1.Menezes J., Lopes J.A., Rodrigues L., Ferreira A. (2006) Aplicações da Tecnologia Analítica de Processos (PAT) - Parte II de III, Controle de Contaminação, 83, 16-22 11.5Reviews and Commentaries 1.Lopes J.A. (2005) Process Analytical Technology: Spectroscopic Tools and Implementation Strategies for the Chemical and Pharmaceutical Industries. Katherine A. Bakeev, Blackwell Publishing Ltd., Oxford, 2005, 451 pp, J. Chemom., 19, 668 669 2.Aksu B., De Beer T., Folestad S., Ketolainen J., Lindén H., Lopes JA, de Matas M., Oostra W., Rantanen J., Weimer M. (2012) Strategic funding priorities in the pharmaceutical sciences allied to Quality by Design (QbD) and Process Analytical Technology (PAT) Commentary, Eur. J. Pharma. Sci., 47, 402-405. Page 29

João Pedro Martins de Almeida Lopes 12. Communications 12.1International scientific conferences 12.1.1 Proceedings in conference actas 20. Lourenço N.D., Almeida C.F., Lopes J.A., Pinheiro H.M., Real time monitoring of a sequencing batch reactor with in-situ NIR spectroscopy, 6thInternational Conference on Environmental Science and Technology, June 25-29 2012, Houston, Texas, USA. 19.Maria J. Melo, Adelaide Miranda, Catarina P. Miguel, Ana Lemos, Ana Claro, Rita Castro, Solange F. Muralha, João A. Lopes, Anónio P. Gonçalves (2011) The colour of medieval Portuguese illumination: an interdisciplinary approach, Revista de História da Arte, Série W, Nº1, 147-175 18.M. Sarraguça, A. Cruz, P. Costa, H. Amaral, J. A. Lopes, NIR as a Multitasking Technique in the Pharmaceutical Field, The 14 th International Conference on Near-infrared Spectroscopy - NIR2009, Bangkok, Thailand, 9/9-13/9, 2009 17.Catarina Miguel, Ana Claro, João A. Lopes, Maria João Melo, Copper pigments in medieval times: Green, blue, greenish blue or bluish green?, Proceedings of the 3rd ATSR conference, ICOM-CC, University of Glasgow, Glasgow, UK, 9/6-10/6 2008 16.M.C. Sarraguça, L.P. Brás, J.A. Lopes, High-throughput pharmaceutical process monitoring:integrating the hardware and software components, Proceedings of the 10th International Chemical andbiological Engineering Conference - CHEMPOR 2008, Braga, Portugal, 4/9-6/9, 2008 (E.C. Ferreira and M. Mota (Eds.)), p.92 (ISBN: 978-972-97810-4-9) 15.O. Preisner, R. Guiomar, J. Machado, J. C. Menezes, J. A. Lopes, FT-IR Spectroscopy and Chemometrics in ClinicalMicrobiology, Proceedings of the 10th International Chemical andbiological Engineering Conference - CHEMPOR 2008, Braga, Portugal, 4/9-6/9, 2008 (E.C. Ferreira and M. Mota (Eds.)), p.940 (ISBN: 978-972-97810-4-9) 14.Paulo, A., A.M.A. Dias, M.C. Sarraguça, J.A. Lopes, M.M. Alves, E.C. Ferreira. Surveying an Activated Sludge Reactor using Online UV-Visible and NIR Spectroscopy and Chemometrics. Proceedings CD of the International Page 30

Symposium on Sanitary and Environmental Engineering - SIDISA 08, Florence, Italy, 24/6-27/6, 2008, 7 pp. (ISBN: 978-88-903557-0-7) 13.Sarraguça M., Lopes J.A., The use of net analyte signal (NAS) in NIR spectroscopy: interpretability and figures of merit, Proceedings of the 11 th International Conference on Chemometrics in Analytical Chemistry - CAC2008, Montpellier, France, 30/6-4/7, 2008, Vol. 1, p. 227-231 12.A. M. A. Dias, I. Moita, R. Páscoa, M. M. Alves, J. A. Lopes, E. C. Ferreira (2007) Activated sludge process monitoring through in-situ NIR spectral analysis, Proceedings on CD-ROM of the 3 rd International IWA Conference on Automation in Water Quality Monitoring - AutMoNet2007, Gent, Belgium, 5/9-7/9, 2007, 8 pp 11.Sarraguça MC, Lopes JA, Quality Control of Pharmaceuticals with NIR: From Lab to Process Line, NIR2007, Proceedings CD of the 13 th International Conference on Near Infrared Spectroscopy - 13th ICNIRS, Umeå-Vasa, Sweden/Finland, 15/6-21/6, 2007 10.Sarraguça MC, Lopes JA, Chemometrics in NIR Spectroscopy Pharmaceutical Applications, Proceedings CD of the 13 th International Conference on Near Infrared Spectroscopy - NIR2007, Umeå-Vasa, Sweden/Finland, 15/6-21/6, 2007 9.Candida C. Felício, Maria A. Santos, Dora M. Nogueira, Joao A. Lopes, José C. Menezes, Optimization of a Petrochemical Visbreaker Unit through Inferential Sensoring, 4 th international symposium on PLS and related methods - PLS2005, Barcelona, Spain, 21/9-24/9, 2005 8.Ana P. Ferreira, Joao A. Lopes, José C. Menezes, Interpretation of the sources of variability of an industrial fermentation process with multiblock PLS, 4 th international symposium on PLS and related methods - PLS2005, Barcelona, Spain, 21/9-24/9, 2005 7.João A. Lopes, Teresa P. Alves, José C. Menezes, Chemometric process analytical technology (PAT) applications in bioprocess engineering, 16 th IFAC World Congress, Prague, Czech Republic, 4/7-8/7, 2005 6.Brás, L.P., Lopes, J.A., Santos, C.R., Cardoso, J.P., Menezes, J.C., Modelling and Identification of an Industrial Pharmaceutical Process by Multiblock PLS, European Symposium of Computer Aided Process Engineering - ESCAPE-14, Lisbon, Portugal, 16/5-19/5, 2004 Page 31

João Pedro Martins de Almeida Lopes 5.Lopes J.A., Menezes J., Trilinear models for batch MSPC: application to an industrial batch pharmaceutical process, European Symposium on Computer Aided Process Engineering ESCAPE 12, The Hague, The Netherlands, 26/5-29/5, 2002(J. Grievink and J. van Schijndel Eds.) p. 709-714 4.Lopes J.A., Menezes J., Industrial Fermentation End-Product Modelling With Multilinear PLS, - Proceedings of the 2 nd International Symposium on PLS and Related Methods PLS 2001, Capri, Italy, 1/10-3/10, 2001(Vinzi, Lauro, Morineau and Tenenhaus Eds.)p. 267-278 3.Lopes, J.A., Menezes, J.C., New Engineering Tools for Improved Supervision and Diagnosis of Pharmaceutical Production Processes, Engineering & Technology 2000 International Workshop - E&T2000, Lisboa, Portugal, 2000 (L. Valadares Eds), p. 78-82 2.Lopes, J.A., Menezes, J.C., Faster development of fermentation processes: early stages process diagnostics, Foundations of Computer-Aided Process Operations FOCAPO98,Snowbird, USA, July 1998, in J. F. Pekny eds., AIChE.Symp.Series, New York, USA, Vol. 94 (320), p. 391-396 1.Lopes, J.A., Menezes, J.C., Faster Development of Fermentation Processes. Intelligent Systems for Penicillin Fermentation Process Modelling, Computer Applications in Biotechnology - CAB7,Osaka, Japan, May 1998, p.333-338 12.1.2Abstracts in conference actas [a completar] 12.1.3Invited lectures 20. JA Lopes,..., SPQ Analítica 2014, Coimbra,... 19. J.A. Lopes, Opportunities and barriers for a life-long scientific career in EU peripheral countries, Invest in Researchers Conference: better training and careers using new funding opportunities, Lithuanian Presidency of the Council of the European Union Conference, Vilnius, 14 15 November 2013 (Enhancing lifelong professional development session) 18. J.A. Lopes, Spectroscopy coupled to chemometrics for vineyards and grapes quality intensive mapping, VIII Colloquium Chemiometricum Mediterraneum, June 30-July 4, 2013, Bevagna, Italy, Plenary PL06, 12-13. Page 32

17. Lopes JA, O estado actual da carreira científica em Portugal. Que futuro?, Dia do aluno da pós-graduação, Universidade do Minho, 12/12 2011, Braga, Portugal. 16. Lopes JA, A investigação científica em Portugal - ANICT, 1ª Congresso de investigadores em Psicologia, Universidade de Trás-os-Montes e Alto Douro, 7-8/11 2011, Vila Real, Portugal. 15. Lopes JA, Fourier-transform infrared spectroscopy: an high-throughput method for pathogenic bacteria screening, XXII Encontro Nacional da SPQ, 3-6/7 2011, Braga, Portugal 14. Lopes JA, Fourier-transform infrared spectroscopy in bacteriology: towards a reference method for bacteria discrimination, IV Congreso Iberoamericano de Quimica Analítica - IVCIAQA, 14-17/11 2010, Concón, Chile 13. Lopes, J.A., Menezes, J.C., New Engineering Tools for Improved Supervision and Diagnosis of Pharmaceutical Production Processes, Engineering & Technology 2000 International Workshop - E&T2000, Lisbon, Portugal, 2000 (L. Valadares Eds), pp. 78-82 12. Lopes JA, Infrared spectroscopy in bacteriology, Faculty of Biochemistry and Biological Sciences, Litoral National University (UNL), 28/11 2010, Santa Fé, Argentina 11. Lopes JA, Identificação e classificação rápida de bactérias por espectroscopia de infra-vermelhos e quimiometria, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisboa, Portugal, 5/7, 2010 10. Lopes J.A.,Process Analytical Technologies (PAT): recent developments and applications in the pharmaceutical industry, Institute of Chemistry/UNESP, Araraquara, Brasil,16/04 2010 9. Lopes JA, Bacteria Identification with FT-IR Spectroscopy: a new method for clinical use?, Bruker s Spectroscopy Seminar Tour, Santa Iria da Azoia, Portugal, 24/10, 2006 8. Lopes J.A., Process Analytical Technology applications in the pharmaceutical industry, June 24, 2005, Faculty of Chemical Engineering, Litoral National University (UNL), Santa Fé, Argentina 7. Lopes J.A., Improving petrochemical units operation through the integration of inferential sensoring and MSPC, June 22, 2005, Faculty of Biochemistry and Biological Sciences, Litoral National University (UNL), Santa Fé, Argentina Page 33

João Pedro Martins de Almeida Lopes 6. Lopes J.A., Supervision and Diagnosis of Industrial Processes, presented by invitation of the VTT Technical Research Centre staff, Tampere, Finland, 17/5, 2004 5. Lopes J.A. and Menzes J.C., Process Analytical Technology, INETI, Lisboa, Portugal, 29/06, 2005 4. Rodrigues, L.O., Ferreira, A.P., Lopes, J.A. Cardoso, J.P., Menezes, J.C., Process Systems Engineering Tools in Pharmaceutical Final Chemicals Production, 2 nd Process Systems Engineering Workshop, Coimbra, Portugal, 3/3, 2004 3. Lopes, V.V., Lopes, J.A., Pinheiro, C.C., Menezes, J.C., Melhoria do Desempenho da Coluna de Destilação de Crude da Refinaria de Sines da Petrogal., Semana Aberta de C&T, IST, Março, 1999 2. Lopes JA and Menezes J.C., Desenvolvimento Rápido de Processos de Produção Farmacêuticos., Semana Aberta de C&T, IST, Março, 1999 1. Lopes, V.V., Lopes, J.A., Pinheiro, C.C., Menezes, J.C., Performance Improvement of an Industrial Crude Distillation Column, Jornadas Tecnológicas, UNL, Abril, 1999 12.1.4Oral communications (presented by João Lopes) 16. Raquel Figueiredo, Rita Matias, Mafalda Sarraguça, João Lopes, A PAT/QbD approach for in-situ monitoring of drug dissolution tests with NIR spectroscopy, XVIII Encontro Luso-Galego de Química, 28-30 November 2012, Vila Real, Portugal, p. 375. 15. M.C. Sarraguça, J.A. Lopes, High-throughput pharmaceutical process quality control (PAT/QbD): a challenge for analytical chemistry, IV Congreso Iberoamericano de Quimica Analítica - IV-CIAQA, 14/11-17/11 2010, Concón, Chile 14.João A. Lopes, Espectroscopia de infra-vermelhos em bacteriologia: implementação como método analítico para discriminação bacteriana, XVI Encontro Luso-Galego de Química, 10/11-12/112010, Aveiro, Portugal 13. Lopes JA, Miguel C.P., Melo M.J., Chemometrics and the medieval scriptorium, Medieval colours: between beauty and meaning, Lisbon/Monte da Caparica, Portugal, 10/09-11/09, 2009 Page 34

17. A. M. A. Dias, A. Paulo, D. Mesquita, M. M. Alves, J. A. Lopes, E. C. Ferreira, Monitoring an activated sludge reactor using IR spectroscopy, Proceedings of the 11th International Conference on Chemometrics in Analytical Chemistry - CAC2008, Montpellier, France, 30 June-4 July 2008, Vol. 2, p. 73 Comentário [u1]: Esta conferencia foi dada por mim. 12. Mafalda C. Sarraguça, Ligia P. Brás, João A. Lopes, High-Throughput Pharmaceutical Process Quality Control (PAT): Practical Implementations and Revenue, 19th International Symposium on Pharmaceutical and Biomedical Analysis PBA2008, Gdańsk, Poland, 8/6-12/6, 2008, (keynote lecture) p.27 11. Lopes JA, Uncertainty Estimation in Chemometrics Based Analytical Chemistry Methods - SPQ-ANALÍTICA 07, 6º Encontro da Divisão de Química Analítica da Sociedade Portuguesa de Química, Lisbon, Portugal, 29/3-30/3, 2007, p.3 10. Sarraguça MC, Lopes JA, Quality Control of Pharmaceuticals with NIR: From Lab to Process Line, NIR2007, Proceedings CD of the 13 th International Conference on Near Infrared Spectroscopy - 13 th ICNIRS, Umeå-Vasa, Sweden/Finland, 15/6-21/6, 2007 9. Candida C. Felício, Maria A. Santos, Dora M. Nogueira, Joao A. Lopes, José C. Menezes (2005) Optimization of a Petrochemical Visbreaker Unit through Inferential Sensoring, 4 th international symposium on PLS and related methods - PLS2005, Barcelona, Spain, 21/9-24/9, 2005 8. João A. Lopes, Teresa P. Alves, José C. Menezes, Chemometric process analytical technology (pat) applications in bioprocess engineering, 16 th IFAC World Congress, Prague, Czech Republic, 4/7-8/7, 2005 7. Lopes J.A., Menezes J.C., Integration of chemometrics methods for the development of industrial antibiotic production processes, Congresso de Métodos Computacionais em Engenharia - CMCE2004, Lisbon, Portugal, 31/5-2/6, 2004 (Eds. C. Soares et al.) p.484 6. Lopes J.A., Menezes J.C., Integration of chemometrics methods for the development of industrial antibiotic production processes, Congresso de Métodos Computacionais em Engenharia, Lisbon, Portugal, 31/5-2/6, 2004 (Eds. C. Soares et al.) p.484 Page 35

João Pedro Martins de Almeida Lopes 5. Lopes J.A. and Menezes J., Chemometrics as an Enabling Science in Bioprocess Engineering, V Colloquimum Chemometricum Mediterraneum - CCM2003, Ustica, Italy, 25/6-27/6, 2003 4. Lopes J.A. and Menezes J., Multivariate Monitoring of Fermentation Processes with Linear and Non-Linear Methods, V Colloquimum Chemometricum Mediterraneum - CCM2003, Ustica, Italy, 25/6-27/6, 2003 3. Lopes, J.A., Menezes, J.C., Supervision and Diagnosis of Pharmaceutical Processes with the Real-Time platform G2/NeurOn Line, 4 th Portuguese Conference on Automatic Control - CONTROLO 2000, Guimarães, Portugal, 4/10-6/10, 2000 2. Lopes J.A., Menezes J., Supervision and diagnosis of pharmaceutical processes with knowledge-based systems, IX International Symposium on Applied Stochastic Models and Data Analysis- ASMDA, Lisbon, Portugal, 14/6-17/6, 1999, pp. 384-391 1. Lopes J.A., Menezes J., Supervision and diagnosis of pharmaceutical processes with G2/NeurOn-Line, Gensym Users Society Meeting- GUS 98, NewPort, USA, 13/5-15/5, 1998 12.1.5Oralcommunications (presented by co-authors) 41. Lopo M*, Santos CAT, Pascoa RNMJ, Graça AR, Lopes JA, Near infrared spectroscopy as a tool for intensive mapping of vineyards soil, XIX Encontro Luso-Galego de Química, 13-15 November 2013, Vigo, Spain, p. 51 (AMA-01) 40. Pascoa RNMJ*, Lopo M, Santos CAT, Lopes JA, Mapping the soil influence on the multi-elementa composition of grape berries, skins and seeds, XIX Encontro Luso-Galego de Química, 13-15 November 2013, Vigo, Spain, p. 53 (AMA-03) 39. Santos CAT*, Lopo M, Pascoa RNMJ, Lopes JA, A bootstrapping approach for estimating uncertainty n latent variable models based on spectroscopy data, XIX Encontro Luso-Galego de Química, 13-15 November 2013, Vigo, Spain, p. 45 (IND-01) 38. Silva AF*, Vercruysse J, Delaet U, Van Assche I, Cappuyns P, Arata F, Caporicci G, Lopes JA, Vervaet C, Remon JP, De Beer T,Statistical process monitoring of a continuous pharmaceutical twin screw granulation and drying process, Page 36

EuPAT6 Sixth pan-european QbD & PAT Science Conference, September 23-24, 2013, Porto, Portugal, O05, pp. 35-36. 37. M. Lopo*, C.A. Teixeira dos Santos, R.N.M.J. Páscoa, A.A.R. Graça, J.A. Lopes, Near infrared spectroscopy as a tool for intensive mapping of vineyards soil, VIII Colloquium Chemiometricum Mediterraneum, June 30-July 4, 2013, Bevagna, Italy, O05, pp. 30-31. 36. C. A. Teixeira dos Santos*, Ricardo N.M.J. Páscoa, João A. Lopes, A review on the applications of portable near infrared spectrometers in the agro-food industry, VIII Colloquium Chemiometricum Mediterraneum, June 30-July 4, 2013, Bevagna, Italy, O37, pp. 89-90 35. Sílvia Mas*, Catarina Miguel, Maria João Melo, João A. Lopes, Anna de Juan, Study of the characterization and quantitation of proteinaceous binders in red medieval paints based on Fourier transform infrared spectroscopy and correlation constrained multivariate curve resolution alternating least squares method, VIII Colloquium Chemiometricum Mediterraneum, June 30-July 4, 2013, Bevagna, Italy, O21, pp. 60-61. 34. M. Carvalho*, S.G. Certal, R.M.Páscoa, S. Cunha, A. Graça and J.A. Lopes, Highthroughput near-infrared spectroscopy based technology for qualifying grapes based on soil and climate conditions, 6th meeting of young researchers of University of Porto-IJUP 2013, 13-15 November 2013, Porto, Portugal, p.318 33. Ricardo N.M.J. Páscoa*, Miguel Braga, João A. Lopes, Avaliação da heterogeneidade de uma vinha por monitorização intensiva com espetroscopia NIR, XVIII Encontro Luso-Galego de Química, 28-30 November 2012, Vila Real, Portugal, p. 60. 32.Ricardo N.M.J. Páscoa, Luís M. Magalhães*,João A. Lopes, Assessment of antioxidant properties of spent coffee ground samples by FT-NIR spectroscopy, XVIII Encontro Luso-Galego de Química, 28-30 November 2012, Vila Real, Portugal, p. 74. 31. Lourenço N.D.*, Almeida C.F., Lopes J.A., Pinheiro H.M., Real time monitoring of a sequencing batch reactor with in-situ NIR spectroscopy, 6thInternational Conference on Environmental Science and Technology, 25-29 June 2012, Houston, Texas, USA. 30. Mafalda Cruz Sarraguça*, Thomas De Beer, Chris Vervaet, Jean-Paul Remon, João Almeida Lopes, A batch modelling approach to monitor a freeze-drying Page 37

João Pedro Martins de Almeida Lopes process using in-line Raman spectroscopy, PharmSciFair 13-17 June 2011, Prague, Czech Republic, p. 68 (SC-67) 29. Mafalda Cruz Sarraguça*, Lien Mahy, Thomas De Beer, Luísa Peixe, João Almeida Lopes, Differentiation of Acinetobacter spp.with intrinsic fluorescence spectroscopy, XII Encontro Galego Português de Química, 9-11 November 2011, Pontevedra, Spain 28.C.P. Miguel*, J. A.Lopes, M.J. Melo, M. Clarke, Oitocentos anos de (al)química em Portugal, XXII Encontro Nacional da SPQ, 3-6 July 2011, Braga, Portugal 27.Andrea C. Galvis-Sánchez*, João Almeida Lopes, Ivonne Delgadillo and António O.S.S. Rangel, Aplicação da espectroscopia de infravermelho para a avaliação da qualidade do sal marinho, XVI Encontro Luso-Galego de Química, 10-12 November 2010, Aveiro, Portugal 26. Queirós A., Santos L., Santos A., Lopes J., Almeida A.,Evaluation of a new approach for estimating the post-mortem interval based on the direct skin surface analysis using FTIR, VI Congresso Ibérico de Espectroscopía - XXII Reunión Nacional de Espectroscopía (VI CIE - XXII RNE), Porto, Portugal, 8-10 September 2010 25. F. Cámara-Martos, F. Pérez-Rodríguez, Carla P. Coutinho, G. Zurera-Cosano, João A. Lopes, Use of fourier transform-near infrared spectra to discriminate pathogenic bacteria in milk, VII Colloquium chemiometricum Mediterraneum - CCM-VII, Granada, Spain, 21-24 June 2010 24. N.D. Lourenço, J.A. Lopes, C.F. Almeida, M.C. Sarraguça and H.M. Pinheiro, Bioreactor monitoring with spectroscopy and chemometrics: a review, VII Colloquium chemiometricum Mediterraneum - CCM-VII, Granada, Spain, 21-24 June 2010 14.Preisner OE, Lopes JA, Guiomar R, Machado J and Menezes JC, Uncertainty assessment in FT-IR spectroscopy based bacteria classification models, 10 th Scandinavium Symposium in Chemometrics - SSC10, Lappeenranta, Finland, 11-15 June 2007, p.44 (O26) 22.C.S.Coutinho, A. Pinto-de-Oliveira, J.A.Lopes,I.Sá-Correia, Use of Fouriertransform infrared spectroscopy (FTIRS) and chemometrics as a new approach to typing of clinical isolates of the Burkholderia cepacia complex, 3 rd Congress of European Microbiologists - FEMS2009, Gothemburg, Sweden, 28 June-2 July 2009 Page 38

21.Preisner OE, Lopes JA, Menezes JC, Uncertainty assessment of clinical microbiologyft-ir spectroscopy chemometrics models,federation of Analytical Chemistry and Spectroscopy Societies - FACSS2009, Louisville, KY, 18-22 Ocotber 2009 20.M. Sarraguça, A. Cruz, P. Costa, H. Amaral, J. A. Lopes, NIR as a Multitasking Technique in the Pharmaceutical Field, 14 th International Conference on Near Infrared Spectroscopy - NIR2009, Bankok, Thailand, 8-13 November 2009 19.Sarraguça M., Brás L., Lopes J.A., High-troughput pharmaceutical process monitoring: integrating the hardware and software components, 10th International Chemical and Biological Engineering Conference - CHEMPOR 2008, Braga, Portugal, 4-6 September 2008 23. Catarina Miguel, Ana Claro, João A. Lopes, Maria João Melo, Copper pigments in medieval times: Green, blue, greenish blue or bluish green?, Proceedings of the 3rd ATSR conference, ICOM-CC, University of Glasgow, Glasgow, UK, 9-10 June 2008 18.O.E. Preisner, J.A. Lopes, J. Machado, R. Guiomar, J. C. Menezes, Contribution of FT-IR spectroscopy and chemometrics to clinical microbiology - epidemiological typing of Klebsiella pneumonia, The 7th European Symposium on Biochemical Engineering Science - ESBES2008, Faro, Portugal, 7-10 September 2008 16.Paulo, A., A.M.A. Dias, M.C. Sarraguça, J.A. Lopes, M.M. Alves, E.C. Ferreira. Surveying an Activated Sludge Reactor using Online UV-Visible and NIR Spectroscopy and Chemometrics. Proceedings CD of the International Symposium on Sanitary and Environmental Engineering - SIDISA 08, Florence, Italy, 24-27 June 2008, 7 pp. (ISBN: 978-88-903557-0-7) 15.Sarraguça MC, Lopes JA, Chemometrics in Vibrational Spectroscopy Pharmaceutical Applications - SPQ-ANALÍTICA 07, 6º Encontro da Divisão de Química Analítica da Sociedade Portuguesa de Química, Lisbon, Portugal, 29-30 March 2007, p.8 13.O.E. Preisner, J. A. Lopes, R. Guiomar, J. Machado, J.C. Menezes, differentiation of selected salmonella enterica serotypes by FTIR and chemometrics, 12 th European Conference on the Spectroscopy of Biological Molecules ECSBM 2007, Bobigny, France, 1-6 September, 2007, p.72. 12.A. M. A. Dias, I. Moita, R. Páscoa, M. M. Alves, J. A. Lopes, E. C. Ferreira (2007) Activated sludge process monitoring through in-situ NIR spectral analysis, Page 39

João Pedro Martins de Almeida Lopes Proceedings on CD-ROM of the 3 rd International IWA Conference on Automation in Water Quality Monitoring - AutMoNet2007, Gent, Belgium, 5-7 September 2007, 8 pp 11.O.E. Preisner, J.A. Lopes, J. Machado, R. Guiomar, J. C. Menezes, Application of FT-IR spectroscopy and chemometrics for differentiation of Salmonella Enteritidis phagotypes, FT-IR Spectroscopy in Microbiological and Medical Diagnostics, Berlin, Germany, 25-26 October 2007 10.Ferreira AP, Lopes JA, Menezes JC, Modelling and End-Product Prediction of Industrial Fermentation Batches Considering Information from Previous Process Stages, 7th Portuguese Conference on Automatic Control CONTROLO 2006, Lisbon, Portugal, 11-13 September 2006 9.Ana P. Ferreira, João A. Lopes, José C. Menezes. (2005) Interpretation of the sources of variability of an industrial fermentation process with multiblock PLS, 4 th international symposium on PLS and related methods - PLS2005, Barcelona, Spain, 21-24 September 2005 8. Felício C.C., Rodrigues, L. O., Lopes, J. A., Cardoso, J. P., Menezes, J. C., Using PAT for Improvement of an Industrial Catalytic Hydrogenation of an Active Pharmaceutical Ingredient, in Process Analytical Technology (PAT) in Organic Process R&D., Boston, USA, 28-29 June 2005 7.Rodrigues, L. O., Lopes, J. A., Cardoso, J. P., Menezes, J. C., Process spectroscopy of an industrial hidrogenation of an active pharmaceutical ingredient, Congresso de Métodos Computacionais Engenharia - CMCE2004, Lisbon, Portugal, 31 May-2 June, 2004 6.Rodrigues, L.O., Lopes, J.A., Cardoso, J.P., Menezes, J.C. (2004) Process Supervision and Diagnosis of an Industrial Catalytic Hydrogenation of an Active Pharmaceutical Ingredient with Process Analytical Technologies (PAT), 8 th International Process Analytical Chemistry & Technology Forum, Arlington, Virginia (USA), 12-15 January, 2004 5. Menezes J.C., Lopes, J.A., Process Chemometrics : Applications in the Industrial Production of Antibiotics., 1st Process Analytical Chemistry Workshop (University of Barcelona), Barcelona, Spain, 13-14 November 2003 4.Lopes J.A., Menezes J., An integrated chemometrics approach to process development for the industrial production of antibiotics, 8 th International Page 40

Conference on Chemometrics in Analytical Chemistry - CAC2002, Seattle, USA, 22-26 September 2002 3.Costa P., Vieira L., Lopes J.A., Menezes J.,Predicting antibiotic productivity in an industrial process from fermentation raw-materials NIR spectra and inocula quality with PLS and artificial neural networks models, 7 th International Conference on Chemometrics in Analytical Chemistry CAC2000, Antwerp, Belgium, 16-20 October 2000, p. 212 2.Menezes J., Pinheiro C., Lopes V., Lopes J.A.,Inferential Monitoring of an Industrial Crude Distillation Column, 2 nd International Workshop on Extraction of Knowledge from Data Bases- EKDB-99, Évora, Portugal, 21 September 1999 1.Lopes, J.A., Menezes, J., New Engineering Tools for Better Processes Faster. Part I. Multivariate Statistical Process Diagnostics of Industrial Antibiotic Production Processes, 7 th International Conference on Chemical Engineering- CHEMPOR 98, Lisbon, Portugal, 26-28 September 1998 12.1.6 Posters 91. M. Sarraguça, P. Ribeiro, J. Lopes, A PAT approach for the on-line monitoring of pharmaceutical co-crystals formation with near infrared spectroscopy, EuroPACT 2014 90. Statistical process monitoring of a continuous pharmaceutical twin screw granulation and drying process,a.f. Tavares da Silva, J. Vercruysse, P. Cappuyns, J.A. Lopes, C. Vervaet, J.P. Remon, T. De Beer, EuroPACT 2014 89.F. Machado, C. Lima, L. Fernandes, J. Sarraguça, J. Lopes, A. Santos, A. Almeida, Firing distance estimation through the analysis of the gunshot residue deposit pattern around the bullet entrance hole using FT-NIR spectroscopy, IJUP2104, Porto, Portugal 88. Sarraguça MC, Ribeiro PRS, Matias R., Lopes JA, A new, simple and sensitive spectrophotometric method for the determination of folic acid in pharmaceutical 1formulations, XXIII Encontro Nacional da SPQ, 12-14 June 2013 (P2.73), p.237 87. Sarraguça JMG, Lima CGA, Lopes JA, Almeida AA, Fernandes LM, Magalhães TMS, Santos A., Estimation of the firing distance based on the direct analysis of Page 41

João Pedro Martins de Almeida Lopes the bullet impact surface using FT-NIR spectroscopy, XXIII Encontro Nacional da SPQ, 12-14 June 2013 (P2.72), p.236 86. Matias AR, Ribeiro PS, Sarraguça MC, Lopes JA, Quality-by-Design applied to dissolution tests: in-situ NIR spectroscopy monitoring, EuPAT6 Sixth pan- European QbD & PAT Science Conference, September 23-24, 2013, Porto, Portugal, P17, pp. 78. 85. Jorge Sarraguça*, João A. Lopes, Rita Castro, Maria João Melo, A new method for mapping colours in medieval illuminated manuscripts, Euroanalysis, 25-29 August 2013, Warsaw, Poland. 84. Jorge M. G. Sarraguça*, Catarina G. A. Lima, Filipe Machado, João A. Lopes, Agostinho A. Almeida, Luís M. Fernandes,Teresa M. S. Magalhães and Agostinho Santos, Using FT-NIR spectroscopy for estimating the firing distance based on the direct analysis of the bullet impact surfasse, Euroanalysis, 25-29 August 2013, Warsaw, Poland. 83. Marta Félix Campos, Maria João Melo*, João A. Lopes, Leslie Carlyle and Márcia Vilarigues, A chemometric approach to the characterisation of oil binders in 19th and early 20th century paintings based on infrared spectroscopy, ICOM- Analytical Spectroscopy in Art and Archaeology at the Rijksmuseum Amsterdam, 23 27 September 2013, Amsterdam, The Netherlands. 82. C. Sousa*, Â. Novais, A. Magalhães, J. Lopes, L. Peixe, Quick and reliable discrimination of clinically-relevant Escherichia coli clones by Fourier transform infrared spectroscopy (FTIR), ECCMID - 23rd European Congress of Clinical Microbiology and Infectious Diseases, 27 30 April 2013, Berlin, Germany, P. 2407. 81. Â. Novais*, C. Sousa, A. Fernandez-Olmos, J. Lopes, T. M. Coque Gonzalez, R. Canton Moreno, L. Peixe, Discrimination of major Escherichia coli clones by matrix-assisted laser desorption/ionisation-time of flight mass spectrometry (MALDI-TOF MS) ECCMID - 23rd European Congress of Clinical Microbiology and Infectious Diseases, 27 30 April 2013, Berlin, Germany, P. 1704. 80. C. Sousa*, A. Nemec, J. A. Lopes, L. Peixe, Rapid and accurate identification of the species of Acinetobacter calcoaceticus-acinetobacter baumannii complex spp. by Fourier transform infrared spectroscopy (FTIR), ECCMID - 23rd European Congress of Clinical Microbiology and Infectious Diseases, 27 30 April 2013, Berlin, Germany, P. 1762. Page 42

79. Jorge Sarraguça, João Lopes, Agostinho Almeida, Liliana Santos, Teresa Magalhães, Agostinho Santos*, Estimation of Post-Mortem interval by direct analysis of the skin surface through FT-NIR, American Academy of Forensic Sciences 2013 Annual Meeting, February 18-23, 2013, Washington, DC, USA 78. Ana Magalhães*, Clara Sousa, Ângela Novais, João Lopes, Luísa Peixe, Quick and reliable discrimination of clinically relevant Escherichia coli clones by Fourier Transform Infrared Spectroscopy (FTIR), 6th meeting of young researchers of University of Porto-IJUP 2013, November 13-15, 2013, Porto, Portugal, p.379 77. Raquel Figueiredo*, Mafalda Sarraguça, Jorge Salvador, João Lopes A new trend for NIR spectroscopy: in-situ monitoring of dissolution tests, EuPAT5, May9-10, 2012, Ghent, Belgium 76. Raquel Figueiredo*, Mafalda Sarraguça, Jorge Salvador, João Lopes, NIR diffuse reflectance spectroscopy to assess tablets dissolution profiles, EuPAT5, 9-10 May, 2012, Ghent, Belgium. 75. Nídia Dana Lourenço*, Cláudio Fernandes de Almeida, João Almeida Lopes, Helena Maria Pinheiro, Real time monitoring of a sequencing batch reactor with in-situ NIR spectroscopy, Sixth International Conference on Environmental Science and Technology ICEST2012, June 25-29, 2012, Houston, USA. 74. João A. Lopes, Ornella E. Preisner, Carla P. Coutinho, Licínia Rodrigues, João G. Henriques, Isabel Sá-Correia, José C Menezes, Infrared Spectroscopy Applications in Microbiology and Bioprocess Monitoring, 1st Meeting of the Institute for Biotechnology and Bioengineering (IBB), P-IBB11, Faro, Portugal, 15/5-16/5 2008 73.Sousa C., Grosso F., Meirinhos Soares L., Lopes J., Peixe L., High-throughput methodologies for tracing Acinetobacter baumannii, Microbiotec 11, 1-3/12 2011, Braga, Portugal 72. Andrea C.Galvis-Sánchez, Inês Santos, Raquel Mesquita, João Lopes, Ivonne Delgadillo, António Rangel,Evaluation of some of the main inorganic ions in brine solutions used for sea salt production by flow injection analysis and Fourier-transform mid-infrared spectroscopy, 5 th International Symposium on Recent Advances in Food Analysis - RAFA2011, 1-4/11 2011, Prague, Czech Republic (Poster G-28) 71. João Rodrigo Santos, Mafalda Cruz Sarraguça, João Almeida Lopes, António O.S.S. Rangel, Authenticity assessment of roasted coffee brands using Page 43

João Pedro Martins de Almeida Lopes near infrared spectroscopy, XVII Encontro Luso-Galego de Química, 9-11/11 2011, Pontevedra, Spain (Poster P-40) 70. João Rodrigo Santos, Mafalda Cruz Sarraguça, João Almeida Lopes, António O.S.S. Rangel, Evaluation of green coffee quality using NIR spectroscopy: a quantitative approach, XVII Encontro Luso-Galego de Química, 9-11/11 2011, Pontevedra, Spain (Poster P-05) 69. João A. Lopes, Fourier-transform infrared spectroscopy: an high-throughput method for pathogenic bacteria screening, Encontro Nacional de Química Analítica da Sociedade Brasileira de Química, 23-26/10 2011, Campos do Jordão, Brasil (Poster BA003). 68. J. M. G. Sarraguça, João A. Lopes, J. L. M. Santos, Mathematical modeling of the analytical signal in single interface flow analysis, Euroanalysis 2011, 11-15/9 2011, Belgrade, Serbia (Poster CM16). 67. M. Sarraguça, J. Lopes, Improved quality control of solid dosage forms for the pharmaceutical industry with high-throughput near infrared spectroscopy, XXII Encontro Nacional da SPQ, 3/6/7 2011, Braga, Portugal 66. J. M. G. Sarraguça, João A. Lopes, J. L. M. Santos, José L. C. Lima, Mathematical modeling of dispersion in Single Interface Flow Analysis: the effect of flow inversion, XXII Encontro Nacional da SPQ, 3/6/7 2011, Braga, Portugal 65.S. Certal, A. Durães, J. Lopes, A. Almeida and C. Couto, Natural and anthropogenic influences on metal content in surface waters of River Douro estuary, 4th Meeting of Young Researchers of University of Porto - IJUP 11, Porto, Portugal, 17/2-19/2 2011 64. S. Soares, H. Amaral, P. Costa, M. Sarraguça and J. Lopes, Near infrared spectroscopy for polymorphism characterization in pharmaceutical solid dosage forms, 4th Meeting of Young Researchers of University of Porto - IJUP 11, Porto, Portugal, 17/2-19/2 2011 63.A. Queirós, J. Lopes, L. Santos, A. Santos and A. Almeida, Preliminary results on the evaluation of a post-mortem interval (PMI) estimating approach based on the direct skin surface analysis using FT-NIR spectroscopy, 4th Meeting of Young Researchers of University of Porto - IJUP 11, Porto, Portugal, 17/2-19/2 2011 Page 44

62.Carla P. Coutinho, Mafalda C. Sarraguça, Jorge M. Sarraguça, Luís Meirinhos- Soares, Mónica Miranda, Raquel Guiomar, Jorge Machado, Ornella E. Preisner, Isabel Sá-Correia, José C. Menezes, João A. Lopes, Fourier-Transform Infrared Spectroscopy in Bacteriology, Encontro Nacional REQUIMTE, Fátima, Portugal, 13/1-14/1 2011 61. Mafalda C. Sarraguça, Cristiana Leandro, João A. Lopes, High-throughput pharmaceutical process quality control (PAT): Practical implementations and revenue; Abstracts of EuPAT Fourth pan-european PAT Science Conference, Poster P6, Kuopio, Finland, 5-6/5 2010 60. Agostinho A. Almeida, Cristina M. C. M. Couto, Ivone Pinto, Tânia Vieira Madureira, Maria João Rocha, Maria Elizabeth Tiritan, João A. Lopes, Estudo da dinâmica espaço-temporal do estuário do rio Douro através da análise multivariada dos níveis de elementos vestigiais, XVI Encontro Luso-Galego de Química, Aveiro, Portugal, 10-12/11 2010 59. Galvis-Sánchez A.C., Lopes J.A., Delgadillo I. and Rangel A.O.S.S.,The use of Fourier-transform near and mid-infraredspectroscopy for sea salt quality characterization, International Diffuse Reflectance Conference - IDRC2010, Chambersburg PA, USA, 1-6/8 2010 58.Filipa Grosso, Clara Sousa, Sandra Quinteira, Luis Meirinhos-Soares, João Lopes, Luísa Peixe, Characterization of carbapenem-resistant Acinetobacter baumannii population using molecular genomic-based typing methods and FT-IR spectroscopy, 9th International Meeting on Microbial Epidemiological Markers - IMMEM2010, Wernigerode, Germany, 1-4/09 2010 57. Nídia D. Lourenço, Cláudio F. Almeida, João A. Lopes and Helena M. Pinheiro, Multivariate statistical process control of a lab-scale biological SBR with inprocess NIR spectroscopy, Chemometrics in Analytical Chemistry - CAC2010, Antwerp, Belgium, 18-21/10 2010 56. Mafalda Sarraguça, Ana Cruz, Helena Amaral, Paulo Costa, João Lopes, Particle size determination in pharmaceutical powders by near infrared spectroscopy, PO1-21, VII Colloquium Chemiometricum Mediterraneum - CCM-VII, Granada, Spain, 21/6-24/6 2010 55. Catarina Miguel, João A. Lopes, Maria João Melo and Mark Clarke, A chemometric approach to the study of the binding media composition on red and blue microsamples from portuguese medieval illuminated manuscripts, PO2-48, VII Page 45

João Pedro Martins de Almeida Lopes Colloquium Chemiometricum Mediterraneum - CCM-VII, Granada, Spain, 21/6-24/6 2010 54.J.M.G. Sarraguça, João A. Lopes, João L. M. Santos, José L. F. C. Lima, Modeling the Analytical Signal in a Flow Injection Analysis Determination, 16th International conference on flow injection analysis, Pattaya, Thailand, 25/4-30/4 2010 53.Catarina P. Miguel,João A. Lopes, Maria J. Melo,Mark Clarke, An infrared approach to unveil the binding medium in Portuguese medieval illuminations, 9 th Biennial International Conference of the Infrared and Raman Users Group - IRUG9, Buenos Aires, Argentina, 3/3-6/3 2010 52.A. Queirós, A. Santos, L. Santos, A. Sousa, J. A. Lopes and A. Almeida, New approaches for estimating the post-mortem interval: Direct skin surface analysis using FTIR spectroscopy, 3rd Meeting of Young Researchers of University of Porto - IJUP 10, Porto, Portugal, 17/2-19/2 2010 51.S. Soares, M. Sarraguça, H. Amaral, P. Costa and J. Lopes, Near infrared spectroscopy for polymorphism characterization and quantification in pharmaceutical solid dosage forms, 3rd Meeting of Young Researchers of University of Porto - IJUP 10, Porto, Portugal, 17/2-19/2 2010 50.Ana V. Cruz, Mafalda C. Sarraguça, Paulo C. Costa, Helena R. Amaral and J. A. Lopes, Near infrared spectroscopy: a tool for diagnosing physical properties of pharmaceutical powders, 3rd Meeting of Young Researchers of University of Porto - IJUP 10, Porto, Portugal, 17/2-19/2 2010 49.M. Sarraguça, A. Cruz, P. Costa, H. Amaral, J. A. Lopes, A Novel Method to Determine Aminoglycosides in Pharmaceutical Solid Formulations. Neomycin as Example, The 14 th International Conference on Near-infrared Spectroscopy - NIR2009, Bangkok, Thailand, 9/9-13/9, 2009 48.J. M. G. Sarraguça, J. A. Lopes, J. L. M. Santos, J. L. F. C. Lima, Mathematical modeling of Flow Injection Analysis analytical signal,flow Analysis XI, Pollensa, Spain, 14/9-18/9, 2009 47. Rodrigues S, Lopes JA, Santos JLM, Marques KL, Lima JLFC, single interface flow analysis (SIFA) modelling and optimization with chemometric methods, Flow Analysis XI, 14-18 September 2009, Pollensa, Spain, p. 162 (P085) Page 46

46.C. Coutinho, O. Preisner, I. Sá-Correia, J. A. Lopes, Discrimination of Burkholderia cepacia complex clinical isolates using Fourier Transform Infrared Spectroscopy and chemometric approaches, MICROBIOTEC 09, Vilamoura, Portugal, 28/9-30/9, 2009, P.259 45.Sandra Soares, Mafalda Sarraguça, Paulo Costa, Helena Amaral, João A. Lopes, Analysis of UV degradation of active pharmaceutical ingredients in powder form with near infrared spectroscopy, II Encontro de Jovens Investigadores da Universidade do Porto - IJUP 09, Porto, Portugal, 25/2-27/2 2009. 44.Ana Cruz, Mafalda Sarraguça, Paulo Costa, Helena Amaral, João A. Lopes, Particle size determination in pharmaceutical powders by near infrared spectroscopy, II Encontro de Jovens Investigadores da Universidade do Porto - IJUP 09, Porto, Portugal, 25/2-27/2 2009. 43.M. Sarraguça, A. Cruz, S. Soares, H. Amaral, P. Costa, J. A. Lopes, Advanced control of pharmaceutical specialties with near-infrared spectroscopy and chemometrics, II Encontro de Jovens Investigadores da Universidade do Porto - IJUP 09, Porto, Portugal, 25/2-27/2 2009. 42.C. Coutinho, I. Sá-Correia, J. A. Lopes, Discrimination of Burkholderia cepacia complex ribopatterns by Fourier Transform infrared spectroscopy and chemometrics, SPEC2008 - Shedding Light on Disease, São José dos Campos, Brazil, 25/10-29/10, 2008, P.15, p.394. 41.C. Coutinho, I. Sá-Correia, J. A. Lopes, Discrimination of Burkholderia cepacia complex bacteria by Fourier-Transform Infrared Spectroscopy and Chemometric modeling, Forum Português Biologia Computacional FPBC 08, Oeiras, Portugal, 10/7-12/7 2008, p.54 40. David S.M. Ribeiro, João A.V. Prior, João A. Lopes, João L.M. Santos, José L.F.C. Lima, Development of a multi-pumping flow system for the spectrophotometric determination of indapamide, 15th Intenational Conference on Flow Injection Analysis - ICFIA, Nagoya, Japan, 28/9-3/10, 2008, P-96. 39.O. Preisner, R. Guiomar, J. Machado, J. C. Menezes, J. A. Lopes, FT-IR Spectroscopy and Chemometrics in Clinical Microbiology, 10th International Chemical and Biological Engineering Conference - CHEMPOR 2008, Braga, Portugal, 4/9-6/9, 2008, p.940 Page 47

João Pedro Martins de Almeida Lopes 38.R. Guiomar, O.Preisner, Z. Videira, J.A. Lopes, J.C. Menezes, J. Machado, Fourier Transform infrared (FT-IR) spectroscopy as an epidemiological typing methodology,8 th International Meeting on Microbial Epidemiological Markers - 8 th IMMEM, Zakopane, Poland, 14/5-17/5 2008, p. 102. 37.Mafalda C. Sarraguça, Ana Cruz, Sandra Soares, Paulo C. Costa, Helena R. Amaral, João A. Lopes, Determination of Physical Parameters in Pharmaceutical Powders by Near Infrared Spectroscopy (NIR), 19th International Symposium on Pharmaceutical and Biomedical Analysis PBA2008, Gdańsk, Poland, 8/6-12/6 2008, p.384 36.Pires A.R., Montenegro M.C.B.S.M., João A. Lopes, Araújo A., Simultaneous determination of thiamine and pyridoxine in multivitaminics by sequential injection analysis (SIA) with potentiometric injection, 19th International Symposium on Pharmaceutical and Biomedical Analysis PBA2008, Gdansk, Poland, 8/6-12/6 2008, p.298 35.Sarraguça M., Lopes J.A., The use of net analyte signal (NAS) in NIR spectroscopy: interpretability and figures of merit, Proceedings of the 11 th International Conference on Chemometrics in Analytical Chemistry - CAC2008, Montpellier, France, 30/6-4/7 2008, Vol. 1, p. 227-231 34.Ana G. Almeida, Carla S. Coutinho, Luís Meirinhos-Soares, João A. Lopes, Identification and Discrimination of Pharmaceutical Relevant Bacteria by Intrinsic Fluorescence, XXI Encontro Nacional da SPQ, Porto, Portugal, 11/6-13/6 2008, p.122 33.David S. M. Ribeiro, João A.V. Prior, João A. Lopes, João L. M. Santos, José L. F. C. Lima, Spectrophotometric Determination of Indapamide in a Multi-Pumping Flow System, XXI Encontro Nacional da SPQ, Porto, Portugal, 11/6-13/6 2008, p.129 32.Mafalda C. Sarraguça, Adriano Fachini, João A. Lopes, Unveiling Chemical and Physical Information from Chemometrics Models, XXI Encontro Nacional da SPQ, Porto, Portugal, 11/6-13/6 2008, p.166 31.A. Cruz, S. Soares, M. Sarraguça, P. Costa, H. Amaral, J. A. Lopes, Determination of physical parameters in pharmaceutical powders by near infrared spectroscopy (NIR), First meeting of young researchers of U.Porto, Porto, Portugal, 20/2-22/2 2008, p.121 Page 48

30.Lopes S., Lopes J.A., Abordagem Quimiométrica no Desenvolvimento de Métodos Cromatográficos para Controlo de Qualidade, Congresso Nacional dos Farmacêuticos, Lisboa, Portugal, 8/3-10/3 2007 29.Sarraguça MC, Lopes JA, Chemometrics in NIR Spectroscopy Pharmaceutical Applications, Proceedings CD of the 13th International Conference on Near Infrared Spectroscopy - NIR2007, Umeå-Vasa, Sweden/Finland, 15-21 June, 2007 28.O. Preisner, J. A. Lopes, J. Machado, R. Guiomar, R. C. Menezes, L. Meirinhos- Soares, FT-IR spectroscopy and chemometrics in microbiological applications, MICRO 07-BIOTEC 07-XXXIII, Lisbon, Portugal, 30/11-2/12 2007, p.224 27. C. Coutinho, O. Preisner, I. Sá-Correia, J. A. Lopes, Classification of Burkholderia cepacia complex isolates by Fourier Transform Infrared specroscopy and chemometrics, MICRO-BIOTEC 07-XXXIII, Lisbon, Portugal, 30/11-2/12, 2007, p. 223 26.A.G. Almeida, L. Meirinhos-Soares, J.A. Lopes, Identification and discrimination of pharmaceutical relevant bacterial by intrinsic fluorescence, MICRO 07- BIOTEC 07-XXXIII, Lisbon, Portugal, 30/11-2/12 2007, p. 114 25.C. Coutinho, O. Preisner, I. Sá-Correia, J. A. Lopes, Classification of Burkholderia cepacia complex isolates by Fourier-transform infrared spectroscopy and Chemometrics, FT-IR Spectroscopy in Microbiological and Medical Diagnostics, Berlin, Germany, 25/10-26/10, 2007 24.A.R. Pires, A. N. Araújo, J.A. Lopes, M.C.B.S.M. Montenegro, Determinação simultânea de vitaminas B1 e B6 em multivitamínicos, com detecção potenciométrica em SIA, 14º Encontro Nacional de Química Analítica, João Pessoa (PB), Brasil, 7/10-11/10, 2007 23.J.A.V. Prior, D.S.R. Ribeiro, J. A. Lopes, J.L.M. Santos, J.L.F.C.Lima, Expeditious kinetic multi-pumping flow approach for bromazepam monitoring in drugs, 14th International Conference on Flow Injection Analysis - ICFIA 2007, Berlin, Germany, 3/9-7/9, 2007, p.68 22.Amorim CG, Lopes JA, Araújo AN, Montenegro MCBSM, Calatayud M., Multitasks flow assembly by SIA and multicommutation, XX Encontro Nacional da Sociedade Portuguesa de Química, Monte da Caparica, Portugal, 14/12-16/12, 2006, p.132 Page 49

João Pedro Martins de Almeida Lopes 21.Páscoa RNMJ, Lopes JA, On-line quantification of important wastewater treatment processes parameters with near-infrared spectroscopy and chemometrics, XX Encontro Nacional da Sociedade Portuguesa de Química, Monte da Caparica, Portugal, 14/12-16/12, 2006, p. 236 20.Preisner OE, Lopes JA, Guiomar R, Machado J, Menezes JC, Fourier Transform Infrared (FT-IR) spectroscopy in bacteriology: towards a reference method for bacteria discrimination, 4th International Conference - Spec2006, Heidelberg, Germany, May 20/5-24/5, 2006, p. 180-181 19.Páscoa RNMJ, Lopes JA, In-situ/on-line monitoring of an industrial wastewater treatment process with near-infrared spectroscopy, 1º Encontro Nacional de Bromatologia, Hidrologia e Toxicologia, Sesimbra, Portugal, 2/6-3/6 2006, Revista Portuguesa de Farmácia, Vol LII (3), 2006, p.89 18.Lopes JA, Lima JLFC, Combining Chemometrics and Near-InfraRed Spectrometry for In-Situ/On-line Monitoring in Analytical and Process Analytical Chemistry, Encontro Nacional do REQUIMTE, Fátima, Portugal, 31/3-1/4, 2006 17.Marques K.L., Santos J.L.M., Lopes J.A., Lima J.L.F.C., Development of a Chemometrics-Assisted Chemiluminesce Method for Simultaneous Determination of Levodopa and Benserazide, 10 th International Conference on Flow Analysis, Porto, Portugal, 3/9-8/9, 2006, p.280 16.Joao A. Lopes, Maria A. Santos, Dora M. Nogueira, José C. Menezes (2005) Improvement of crude heaters operation in the petrochemical industry through the integration of PLS and MSPC, 4 th international symposium on PLS and related methods - PLS2005, Barcelona, Spain, 21/9-24/9, 2005 15.Lopes J.A., Ferreira A.P., Menezes J.C., Improvements in Pharma Production Monitoring by High throughput Spectroscopy, Workshop on Biospectroscopy and Data Analysis, Reims, France, 29/6-1/7, 2005, pp. 56 14.Lopes J.A., Lopes V.V., Santos M.A., Nogueira D.M. (2004) Menezes J.C., Implementation of MSPC in the petrochemical industry for crude heaters monitoring and diagnosis, 9 th International Conference on Chemometrics in Analytical Chemistry - CAC2004, Lisbon, Portugal, 20/9-23/9, 2004, p. 239 13.Brás L.P., Lopes J.A., Menezes J.C. (2004) Different Applications of the Multiblock PLS Modelling Approach, 9 th International Conference on Chemometrics in Analytical Chemistry - CAC2004, Lisbon, Portugal, 20/9-23/9, 2004, p. 240 Page 50

12.Rodrigues L., Lopes J.A., Cardoso J.P., Menezes J.C., A PAT Study of an Industrial Catalytic Hydrogenation of an Active Pharmaceutical Ingredient, European Symposium on Computer Aided Process Engineering - ESCAPE-14, Lisbon, Portugal, 16/5-19/5, 2004 11.Brás L., Lopes J.A., Santos C., Cardoso J. and Menezes J., Modelling and identification of individual contributions in an industrial pharmaceutical process by multiblock PLS,V Colloquimum Chemometricum Mediterraneum - CCM2003, Ustica, Italy, 25/6-27/6, 2003 10.Rodrigues L., Zillian A., Lopes J.A., Cardoso J. and Menezes J., Monitoring an industrial catalycal reaction with an FT-NIR transflectance probe, 11 th International Conference on Near-Infrared Spectroscopy NIR2003, Cordoba, Spain, 6/4-11/4, 2003 9.Lopes J.A. and Menezes J.C., An integrated chemometrics approach to process development for production of antibiotics, 11 th International Conference on Near-Infrared Spectroscopy NIR2003, Cordoba, Spain, 6/4-11/4, 2003 8. Lopes J.A., Menezes J.C. (2002) Trilinear Models for Batch MSPC: Application to an Industrial Batch Pharmaceutical Process, European Symposium on Computer Aided Process Engineering ESCAPE 12, The Hague, The Netherlands, 26/5-29/5, 2002 (J. Grievink and J. van Schijndel Eds.) p. 709-714 7.Costa P., Vieira L., Lopes J.A., Menezes J., Monitoring glycerol, phosphate, clavulanic acid and biomass concentrations simultaneously with near-infrared spectroscopy in whole broth industrial samples, 3 rd European Symposium on Biochemical Engineering Science ESBES-3, Copenhagen, Denmark, 10/9-13/9, 2000 (J. Nielsen et al. Eds.) p. 257 6. Lopes, V., Menezes, J.C., Lopes, J.A., Pinheiro, C., Dynamic Monitoring of an Industrial Distillation Process, Applied Stochastic Models and Data Analysis ASMDA-99, 14/6-17/6, 1999 (H. Bacelar-Nicolau, F.C. Nicolau, J. Janssen) p. 436 5. Lopes, J.A., Neves, A.T., Pereira, D.A., Menezes, J.C., Industrial Fermentation Processes Development - Engineering Tools for Better Processes Faster. 2 nd European Symposium on Biochemical Engineering ESBES-2, Porto, Portugal, 16/9-19/9, 1998 (S.F. de Azevedo, E.C. Ferreira, K.Ch.A.M. Luyben e P. Osseweijer, Eds.), p.238 Page 51

João Pedro Martins de Almeida Lopes 4.Lopes, J.A., Menezes, J.C., Faster Development of Fermentation Processes. III. Intelligent Systems forfermentation Process Modelling, 1 st Ibero-American Meeting on Biotechnology BIOTECH 98, Guimarães, Portugal, 12/7-15/7, 1998 3.Lopes J.A., Menezes, J., Faster Development of Fermentation Processes - IV - Early Stages Process Diagnosis of Industrial Antibiotic Production Processes, 1 st Ibero-American Meeting on Biotechnology BIOTECH 98, Guimarães, Portugal, 12/7-15/7, 1998 2.Lopes, J.A., Menezes, J., Faster Development of Fermentation Processes. Early Stages Process Diagnostics, Opportunities for Pharmaceutical R&D in Portugal, Oeiras, Portugal, 20/2-21/2, 1998 1.Lopes, J.A., Menezes, J.C., Faster development of fermentation processes: early stages process diagnostics, Foundations of Computer-Aided Process Operations FOCAPO98, Snowbird, USA, 5/7-10/7, 1998 Page 52

13. Academic activities 13.1 Scientific collaborations 13.1.1 International collaborations 1. 1997-1998 - Centre for Process Analysis and Chemometrics, CPAC, University of NewcastleUpon Tyne (Prof. Julian Morris) (Empirical modelling of fermentation processes) 2. 2004 - Universitat Barcelona, Chemometrics group (Prof. Xavier Saurina) (Deconvolution of near infrared spectral profiles) 3. 2006-2007 - Statistics and Chemometrics Research Group, Norwegian Food Research Institute, Matforsk, Norway (Prof. Harald Martens)(Optimization of spectral preprocessing methods EMSC) 4. Since2006- Instituto de Desarrollo y Diseño, INGAR - CONICET, Santa Fé, Argentina (Prof. Ernesto Martinez) (Integration of chemometrics and reinforcement learning for the monitoring of biological processes) 5. Since 2008- Laboratory for Drug Analysis, Department of Pharmaceutical Analysis, Faculty of Pharmaceutical Sciences, University of Gent, Belgium (Prof. Thomas De Beer)(Raman spectroscopy as a process analytical technology tool for freeze-frying processes monitoring) 6. Since 2009 -Grupo de Investigación HIBRO, University of Cordoba, Spain (Dr. Fernando Câmara-Martos)(FT-NIR spectroscopy for pathogens detection and spoilage flora in foods assessment) 7. Since 2010 - Universidade Autónoma de Barcelona, Spain (Prof. Marcel Blanco) (PAT applications in the pharmaceutical industry) 8. Since 2010 - Instituto de Química, UNESP, Brasil (Prof. Helena Pezza) (Nearinfrared spectroscopy of biodiesel and fossil fuels) 9. Since 2011- Health Sciences Faculty, University of Easter Finalnd (Prof. Jarkko Ketolainen) (Monitoring of freeze-drying processes of biopharmaceuticals). 10. Since 2012 - Centro de Ciências Sociais, Saúde e Tecnologia - CCSST Page 53

João Pedro Martins de Almeida Lopes Universidade Federal do Maranhão (Prof. Paulo Roberto da Silva Ribeiro) (Spectroscopic characterization of solid forms and co-crystals of antihypertensive drugs). 13.1.2 National collaborations 1. Since 2005 - IBB, Departamento de Engenharia Química, IST/UTL (Prof. José Cardoso Menezes) (Chemometrics methods for FTIR spectral analysis with microbiological applications) 2. Since 2006 - Departamento de Enterobactérias, Centro de Bacteriologia e Micologia Professor Arnaldo Sampaio, Instituto Nacional de Saúde Dr. Ricardo Jorge, INSA (Dr Jorge Machado) (Bacteria typing with FTIR spectroscopy and chemometrics methods) 3. Since 2006 - IBB, Departamento de Engenharia Química, IST/UTL, (Prof. Isabel Sá- Correia) (FTIR diagnosis of the Burkholderia cepacia complex) 4. Since 2006 - Departamento de Microbiologia, Instituto Nacional da Farmácia e do Medicamento (INFARMED) (Dr. Luís Soares) (Chemometrics applications to diagnose bacterial pathogens in pharmaceutical relevant products) 5. 2006-2007 - FCT/UNL - Departamento de Química, Faculdade de Ciências e Tecnologia (Prof. João Paulo Crespo, Dr Carla Portugal) (Monitoring of proteins adsorption to ultra-filtration membranes with NIR) 6. Since 2007 - Departamento de Tecnologia Farmacêutica, FF, UP (Prof. Paulo Costa, Prof. Helena Amaral) (Characterization of physical parameters of solid oral dosage forms with near-infrared spectroscopy) 7. Since 2007 - Departamento de Química, Faculdade de Ciências e Tecnologia, FCT/UNL (Prof. Rui Oliveira, Prof. Maria Ascensão Reis) (Optimization, monitoring and control of polyhydroxyalkanoates production by mixed microbial cultures) 8. Since 2007 - Departamento de Conservação e Restauro, Faculdade de Ciências e Tecnologia, FCT/UNL (Prof. Maria João Melo) (Chemometrics analysis of medieval illuminations monitored by FTIR) Page 54

9. Since 2007 - Departamento de Engenharia Bioquímica, Universidade do Minho (Prof. Eugénio Campos Ferreira, Dr. Ana Dias) (Use of in-situ spectroscopic techniques to monitor wastewater treatment processes on-line) 10. Since 2008 - Departamento de Química, Faculdade de Ciências e Tecnologia, FCT/UNL (Dr Gilda Carvalho) (Determination of wastewater pharmaceutical pollutants with miniaturized spectroscopic systems) 11. Since 2010 - Laboratório Nacional de Investigação Veterinária (LNIV) (Dr Ana Botelho, Dr Mónica Cunha) (Use of FTIR for the diagnosis of mycobacteria) 12. Since 2010 - Serviço de Medicina Legal, Faculdade de Medicina, Universidadedo Porto, Portugal. Centro de Ciências Forenses, Instituto Nacional de Medicina Legal (Prof. Dr Agostinho Santos) (Determination of the Post-mortem interval (PMI) using near-infrared spectroscopy) 13. Since 2010 - Escola Superior de Biotecnologia, Universidade Católica Portuguesa (Prof. Dr. António Rangel, Dr. Andrea Galvis-Sánchez) (Infrared spectroscopy methods for food analysis and POD authenticity studies) 14. Since 2011 - Departamento de Química, Faculdade de Ciências, Universidadedo Porto, Portugal (Prof. DoutoraPaula Gameiro, Doutora Maria Feio) (Biospectroscopy of E. coli mutants) 15. Since 2011 Instituto Politécnico de Bragança (Dr. Luís Cabrita) (Antioxidant capacity of natural plant extracts) 16. Since 2013 - ADVID - Associação para o Desenvolvimento da Viticultura Duriense (Dr. Fernando Alves) 13.2Participation in thesis boards 13.2.1 By invitation 10. TESE UNL 9. Cláudia Filipa Reis Galinha Loureiro, Monitoring and modelling of membrane bioreactors for wastewater treatment incorporating 2D fluorescence spectroscopy, PhD Thesis in Chemical and Biochemical Engineering specialty of Biochemical Engineering, Faculdade de Ciências e Tecnologia Page 55

João Pedro Martins de Almeida Lopes da Universidade Nova de Lisboa, Caparica, Portugal, 26/03/2012 (thesis board questioner) 8. Ana Rita Gonçalves da Cruz Ramos Pires, Acoplamento de detectores potenciométricos a sistemas de fluxo para análise de formulações multicomponente, PhD Thesis in Pharmaceutical Sciences, Faculdade de Farmácia, Universidade de Lisboa, Lisboa, Portugal, 19/7/2011(thesis board member) 7. Paulo Jorge Pereira Paixão, In silico prediction of human oral bioavailability. Artificial neural networks and physiologically based models, PhD Thesis in Pharmaceutical Sciences, Faculdade de Farmácia, Universidade de Lisboa, Lisboa, Portugal, 16/7/2010 (thesis board questioner) 6. Célia Maria Pinto Gomes Amorim, Avaliação da utilização de sensores renováveis miniaturizados na análise de drogas e tóxicos em diversas matrizes, PhD Thesis in Analytical Chemistry,Faculdade de Farmácia, Universidade do Porto, Porto, Portugal, 29/7/2009(thesis board member) 5. Sílvia Teresa Santos da Silva Rosa, Near-infrared spectroscopy applications on pharmaceutical manufacturing of solid oral dosage forms, in a quality assurance perspective, PhD Thesis in Biotechnology, Instituto Superior Técnico, Universidade Técnica de Lisboa, Lisboa, Portugal,13/3/2009(thesis board questioner) 4. João Miguel Lopes Dias, Metabolic modeling and optimization of polyhydroxyalkanoates production by mixed microbial cultures, PhD Thesis in Chemical Engineering/Biochemical Engineering, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal, 7/5/2008(thesis board questioner) 3. Filipe Ataíde, Experimental design methodologies for the identification of Michaelis Menten type kinetics, MSc Thesis in Chemical Engineering and Biochemistry, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Lisboa, Portugal, 17/12/2007(thesis board questioner) 2. Maria Inês Sardinha Gomes, Monitorização do crescimento de um biofilme fotossintético por análise de imagem, MSc Thesis inconservation Studies, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Lisboa, Portugal, 26/11/2008(thesis board questioner) Page 56

1. Ana Maria da Silva Paulo, Monitoring of Biological Wastewater Treatment Processes using Indirect Spectroscopic Techniques, MSc Thesis in Environmental Management, Departamento de Engenharia Biológica, Universidade do Minho, Braga, Portugal, 19/12/2008(thesis board questioner) 13.2.3Own students 9. Raquel Maria Tenório da Silva, High-throughput assessment of FTIR spectroscopy for morphological characterization of E.coli mutants, MSc in Pharmaceutical Engineering, Faculty of Pharmacy, University of Lisbon, October 8, 2012. 8. Raquel de Queiroz Portela Mendes de Figueiredo, Manufacturing process and quality control of solid dosage forms optimization for the pharmaceutical industry by near infrared spectroscopy and chemometric analysis, MSc in Industrial Pharmaceutical Chemistry, Faculty of Pharmacy, University of Coimbra, September 24, 2012. 7. Carla Patrícia da Silva Coutinho, Differentiation of clonal variants of the Burkholderia cepacia complex isolated during chronic respiratory infection in cystic fibrosis patients with FTIR spectroscopy, PhD in Pharmaceutical Sciences, Faculdade de Farmácia, Universidade do Porto, March 25, 2011 6. Mafalda Sofia Coelho Cruz Sarraguça, Improved qualilty control of solid dosage forms for the pharmaceutical industry with high-throughput vibrational spectroscopy, PhD in Pharmaceutical Sciences, Faculdade de Farmácia, Universidade do Porto, December 6, 2010 5. Ornella E. Preisner (as co-supervisor), Identification of pathogenic bacteria by Fourier-transform infrared (FT-IR) spectroscopy and chemometrics, PhD Thesis in Biotechnology, Instituto Superior Técnico, Universidade Técnica de Lisboa, September 17, 2009 4. Sandra Sofia Mota Rodrigues, Modelização matemática do fenómeno de dispersão em sistemas de fluxo de interface única, MSc Thesisin Quality Control, Faculdade Farmácia, Universidade do Porto, July 23, 2009 3. Mónica Cancela de Abreu G.V. Almeida Miranda, Aplicação de espectroscopia de FTIR para a serotipagem e avaliação da susceptibilidade à penicilina em Streptococcus pneumoniae, MSc Thesis in Clinical Microbiology, Faculdade de Medicina, Universidade de Lisboa, May 14, 2008 2. Sandra Brogueira Lopes, Desenvolvimento acelerado de separações cromatográficas na industria farmacêutica com métodos quimiométricos, MSc Page 57

João Pedro Martins de Almeida Lopes Thesis in Chemical Engineering-Applied Chemistry, Instituto Superior Técnico, Universidade Técnica de Lisboa, May 18, 2007 1. Ricardo N.M.J. Páscoa, Monitorização In-Situ de Processos de Tratamento de Águas Residuais com Espectroscopia de Infra-Vermelhos Próximos, MSc Thesis in Environmental Chemistry, Faculdade de Farmácia, Universidade do Porto, December 6, 2006 13.3Reviewing activities 13.3.1 Scientific projects 1.Reviewer of scientific projects for the Research Foundation Flanders(FWO), Belgium (http://www.fwo-eloket.be/) 2. Reviewer of scientific projects and grants for the National Research Council of Romania (CNCS http://www.cncs-uefiscdi.ro/home/). 13.3.2 Scientific articles 1.Regular reviewer of the journals (impact factors shown inside parenthesis):journal of Process Control (2.235), Talanta (3.29), Chemometrics and Intelligent Laboratory Systems (2.111), Journal of Chemometrics 1.291), Analytical and Bioanalytical Chemistry (3.480), Biotechnology and Bioengineering (3.377), Biotechnology Progress (2.398), Journal of Pharmaceutical and Biomedical Analysis (2.453), Analytica Chimica Acta (3.757), Spectrochimica Acta Part A (1.566), Applied Environmental Microbiology (3.686), Food Chemistry (3.146), Food Research International (2.416). 13.4Editorial boards 1. Member of the editorial board of ISRN Analytical Chemistry (since 2011) (http://www.isrn.com/journals/ac/) 2. Member of the editorial board of Advances in Chemistry (since 2013) (http://www.hindawi.com/journals/ac/) 3. Member of the editorial board of the Project SCIENTIA@PT for divulgation of scientific achievements of researchers working in Portugal - Contents distributed by the Periodic SOL - http://sol.sapo.pt(since 2011) Page 58

4. Leading guest editor of the special issue High-Throughput Spectroscopy for the Analysis of Microbial Contamination in Food Products" for Journal of Analytical Methods in Chemistry (other guest editors: Fernando Pérez-Rodríguez (Univ. Cordoba) and Clara C. Sousa (Univ. Porto)) (http://www.hindawi.com/journals/jamc/) 13.5Conferences organization 13.5.1 As Chairman 1.Chairman of the Sixth Pan-European Process Analytical Technology Science Conference- EuPAT6, September 22-24, 2013, Porto, Portugal 13.5.2 As Member of the Organizing committee or Scientific board 1.Organizing committee of the 9th International Conference on Chemometrics in Analytical Chemistry - CAC2004, September 20-23, 2004, Lisbon, Portugal (Chairman: José Cardoso Menezes,TU Lisbon) 2. Organizing committee of the EUPAT4 conference, Fourth pan-european Process Analytical Technology Science Conference, 5th - 6th May 2010, Kuopio, Finland (Chairman: Jarkko Ketolainen, University of Eastern Finland) 3. Organizing committee of the 1st National Meeting of ANICT, 8th May 2010, Universidade Nova de Lisboa,Lisboa (Chairman: João Rodrigues, IHMT/UNL) 4.Organizing committee of the 2nd National Meeting of ANICT, 10th September 2011, Fundação Eng. António de Almeida, Porto (Chairman: Miguel Jorge, FEUP) 5.Organizing committee of the EUPAT5 conference (organized by the PAT network of EUFEPS), Fifth Pan-European Process Analytical Technology Science Conference, 9th - 10th May 2012NH Hotel Ghent Belfort, Ghent, Belgium (Chairman: Thomas de Beer, University of Ghent) 6.Organizing committee of the 3rd National Meeting of ANICT, 15th June 2012, University of Coimbra, Coimbra (Chairman: Nicolas Lori, UC) Page 59

João Pedro Martins de Almeida Lopes 7.Scientific committee of the XIX Portuguese-Galician Chemistry Meeting, 13-15th November 2013, Vigo, Spain (Chairman: Pelayo Rubido Muñiz, Col. Oficial de Químicos de Galicia) 8.Organizing committee of the Raising Research Voices Conference, 22-23th November 2013, Brussels, Belgium (Organized by the European Commission (EURAXESS) and Voice of the Researchers initiative). 13.5.3 Conferences participation as moderator or pannel member 1.Moderation of the Rights sessions at the Raising Research Voices Conference, 22-23November 2013, Brussels, Belgium (organized by the European Commission (EURAXESS) and Voice of the Researchers initiative) 2.Pannel member of the Enhancing lifelong professional development session of the Invest in Researchers Conference: better training and careers using new funding opportunities, Lithuanian Presidency of the Council of the European Union Conference, Vilnius, 14 15 November 2013 3.Moderator of the sessions in 3rd National Meeting of ANICT, 15June 2012, University of Coimbra, Coimbra (Chairman: Nicolas Lori, UC) Page 60

14. Organizations 14.1 Steering committees and directive boards 4.President of the Directive Board of Associação Nacional de Investigadores em Ciência e Tecnologia (ANICT) since March 2013 (http://www.anict.pt) 3. Member of the Steering Committee of the Voice of the Researchers initiative promoted by the Directory of Research and Science of the European Commission (since 2012) 2. Member of the Steering Committee of the European Federation for Pharmaceutical Sciences (EUFEPS) QbD and PAT Sciences Networksince 2009(http://www.eufeps.org/PATnetwork.html) 1. Member of the Directive Board (Treasurer) of Associação Nacional de Investigadores em Ciência e Tecnologia (ANICT) since Jan 2011 (http://www.anict.pt) 14.2Membership 4. Member of EuroScience since 2013 (http://www.euroscience.org) 3.Member of Associação Nacional de Investigadores em Ciência e Tecnologia (ANICT) since 2010 (http://www.anict.pt) 2. Member of the Portuguese Chemical Society (Sociedade Portuguesa de Química) since 2007 (http://www.spq.pt) 1. Member of the Portuguese Association of Engineers (Ordem dos Engenheiros) since 1998 (http://www.ordemengenheiros.pt/pt/) Page 61

João Pedro Martins de Almeida Lopes 15. Complementary informations 15.1 Diplomes 1.Diplome corresponding to the 6th year of French language byalliance Française (issued in 1991) 2.Pedagogical course for teacher trainers certificate (Certificado de aptidão pedagógica de formador - CAP) (issued in 2006) 3.SQL Server initiation course, CAP Gemini (issued in 2000) 15.2Languages Language Reading Writing Conversation Portuguese Excellent Excellent Excellent English Excellent Excellent Excellent French Excellent Excellent Excellent Castellan Excellent Basic Good 15.3Computer languages Software Company Level of expertise MATLAB Mathworks Excellent G2 Gensym Excellent PhP Excellent Visual Basic Microsoft Excellent SQL --- Very Good LABVIEW Nat. Instrum. Very good HTML --- Very good C++ --- Good Page 62

15.4Additional informations 1.Senior Consultant ofworldmetricssolutions(http://www.worldmetrics.net) since 2007 2.Regular practice of BTT, trekking, tennis and swimming Page 63