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Under the auspices of EFSUMB European Federation of Societies for Ultrasound in Medicine and Biology INTERNATIONAL COURSE IN: CONTRAST ENHANCED ULTRASOUND IN LIVER, BILIARY, PANCREATIC AND GASTROINTESTINAL DISEASE Course Directors: Dr. Fabio Piscaglia Prof. Luigi Bolondi Bologna, September 17-19, 2009

Invited Speakers Luigi Bolondi (Bologna, I ) Enrico Brunetti (Pavia, I) Peter N.T. Burns (Toronto, CDN) Fabrizio Calliada (Pavia, I) Giuseppe Caruso (Palermo, I) Clotilde Della Pina (Pisa, I) Stefan Delorme (Heidelberg,D) Giulio Di Candio (Pisa, I) Cristoph F. Dietrich (Bad Mergentheim, D) Mirko D Onofrio (Verona, I) Odd Holger Gilja (Bergen, N) Gian Luca Grazi (Bologna, I) Steen Karstrup (Copenhagen, DK) Nathalie Lassau (Paris, F) Edward Leen (London, UK) Gianni Morana (Treviso, I) Fabio Piscaglia (Bologna, I) Carla Serra (Bologna, I) Andreas Schuler (Geislingen, D) Luigi Solbiati (Busto Arsizio, I) Ioan Sporea (Timisoara, R) Guido Torzilli (Milano, I) Hans Peter Weskott (Hannover, D) 2 Chairmen Libero Barozzi (Bologna, I) Luigi Bolondi (Bologna, I ) Peter N.T. Burns (Toronto, CDN) Fabrizio Calliada (Pavia, I) Giulio Di Candio (Pisa, I) Cristoph F. Dietrich (Bad Mergentheim, D) Stefan Delorme (Heidelberg,D) Mirko D Onofrio (Verona, I) Case presenters Libero Barozzi (Bologna, I) Enrico Brunetti (Pavia, I) Fabrizio Calliada (Pavia, I) Cristoph F. Dietrich (Bad Mergentheim, D) Mirko D Onofrio (Verona, I) Francesco Maria Drudi (Roma, I) Francesco Maria Drudi (Roma, I) Carlo Filice (Pavia, I) Odd Holger Gilja (Bergen, N) Steen Karstrup (Copenhagen, DK) Edward Leen (London, UK) Paolo Ricci (Roma, I) Hans Peter Weskott (Hannover, D) Odd Holger Gilja (Bergen, N) Edward Leen (London, UK) Paolo Ricci (Roma, I) Carla Serra (Bologna, I) Hans Peter Weskott (Hannover, D) ENDORSEMENTS Associazione Italiana Studio Fegato (AISF) Società Italiana di Radiologia Medica (SIRM) Società Italiana di Malattie Infettive e Tropicali (SIMIT) Società Italiana di Ultrasonologia in Medicina e Biologia (SIUMB)

Thursday, September 17 th 2009 09.00 Registrations 10.00 Welcome address BASICS OF CEUS Ch a i r m e n: C.F. Dietrich, F. Piscaglia 10.30 Physical principles of contrast agents and detection technologies. Past and present P.N.T. Burns 11.00 Safety of ultrasound contrast agents G. Caruso 11.20 Is written informed consent necessary? Can we use USCA in children? A. Schuler 11.35 Discussion 11.45 Practical recommendations for contrast liver exploration: settings and errors avoidance F. Piscaglia 12.05 Recommended minimal and optimal requirements of CEUS scan documentation S. Karstrup 12.20 Terminology for CEUS reporting F. Calliada 12.35 How to build up the reimbursement cost for CEUS? Should referral exams costs more? A. Schuler 12.55 Question time 13.10 Lunch Break 3

14.30 SIEMENS 14.50 ESAOTE 15.10 PHILIPS Thursday, September 17 th 2009 Technology corner (15 min presentations + 5 min questions) 4 BENIGN LIVER LESIONS Ch a i r m e n: F. Calliada, S. Karstrup 15.30 Hemangioma and focal fatty alteration I. Sporea 15.45 Focal Nodular Hyperplasia and Adenomas C.F. Dietrich 16.05 Break 16.30 CT and MR investigations in benign liver lesions C. Della Pina 16.50 Clinical management of hemangioma, FNH, adenoma G.L. Grazi 17.10 Discussion 17.20 Interactive clinical case presentations (in separate rooms for beginners and advanced) 18.00 Closure of the day

Friday, September 18 th 2009 LIQUID LESIONS AND MALIGNANT TUMORS Ch a i r m e n: L. Barozzi, H.P. Weskott 09.00 Liver cysts and hydatidosis E. Brunetti 09.20 CEUS and trauma S. Karstrup 09.45 Discussion 09.50 Metastasis H.P. Weskott 10.10 Diagnostic flow chart of liver nodules in cirrhosis and characterization of portal vein thrombosis F. Piscaglia 10.40 Discussion 10.50 Break MALIGNANT TUMORS Ch a i r m e n: L. Bolondi, S. Delorme 11.10 Therapeutic management of HCC: guidelines L. Bolondi 11.35 CEUS appearance and diagnostic flow chart in peripheral and ductal cholangiocellular carcinoma and gallbladder lesions E. Leen 12.00 Live demonstrations F. Piscaglia, C. Serra 13.15 Lunch break 5

14.10 GE 14.30 BRACCO Friday, September 18 th 2009 Technology corner (15 min presentations + 5 min questions) 6 CEUS IN THE DIAGNOSTIC ASSESSMENT OF LIVER TUMORS Ch a i r m e n: C. Filice, P. Ricci 14.50 Interventional US guided by CEUS S. Karstrup 15.15 Cost efficiency aspects of CEUS in colorectal cancer S. Delorme 15.30 When is CEUS cost-effective in in the different settings of non-colorectal cancer patients? H.P. Weskott 15.45 Discussion Ch a i r m a n: F. Piscaglia 16.00 Diagnostic strategies when CEUS of incidental focal liver lesion is inconclusive: what next according to the clinical scenarios? (interactive panel discussion: S. Delorme. S. Karstrup, H.P. Weskott) 16.30 Break TECHNOLOGICAL ADVANCES Ch a i r m e n: F.M. Drudi, E. Leen 16.50 Intraoperative CEUS, instrumentation, findings and timing: never, occasionally or always? G. Torzilli 17.10 Fusion imaging systems L. Solbiati 17.30 CEUS and CT/MRI modalities in the assessment of locoregional treatment of HCC and mets L. Solbiati 17.50 Discussion 18.00 Closure of the day

Saturday, September 19 th 2009 08.40 Interactive clinical case presentations (in separate rooms for beginners and advanced) TUMOR RESPONSE ASSESSMENT Ch a i r m e n: P.N.T. Burns, C.F. Dietrich 09.20 Quantification softwares: technical standpoint and future technical perspectives E. Leen 09.40 CEUS in the assessment of systemic tumor treatments. Current results and future expectations: research or clinical tool? N. Lassau 10.00 Discussion 10.10 Break PANCREAS - 1 Ch a i r m e n: G. Di Candio, H.P. Weskott 10.30 Practical recommendations in CEUS exploration of the pancreas M. D Onofrio 10.45 Transcutaneous CEUS assessment of solid and liquid pancreatic masses M. D Onofrio 11.15 Endoscopic assessment of the pancreas and contribution of advanced ultrasound techniques C.F. Dietrich 11.35 Discussion 7

8 Saturday, September 19 th 2009 PANCREAS - 2 Ch a i r m e n: M. D Onofrio, O.H. Gilja 11.45 Live demonstrations (including methodology for intestinal exploration) F. Piscaglia, C. Serra 12.10 Recommended diagnostic flow-chart in pancreatic masses G. Morana 12.30 Is there an indication to CEUS in patients with acute pancreatitis and contraindications to CT? G. Di Candio 12.40 Therapeutic approach to pancreatic masses: solid and liquid G. Di Candio 13.00 Discussion 13.10 Lunch break GASTROINTESTINAL TRACT Ch a i r m a n: L. Bolondi 14.30 Inflammatory bowel disease: conventional ultrasound O.H. Gilja 14.55 GI diseases: CEUS assessment C. Serra 15.25 Discussion 15.30 A look into the future of microbubbbles P.N.T. Burns 15.50 Interactive case presentation in GI and pancreas M. D Onofrio, O.H. Gilja, C. Serra 16.15 Closure of the course

General Information MEETING VENUE Aula Magna Nuove Patologie Padiglione 5 Università di Bologna Policlinico S. Orsola-Malpighi Via Massarenti, 9 - Bologna The congress venue is located 10 minutes from Bologna s city centre. It can easily be reached by means of public transportation system. AIRPORT The airport is located 10 km from the city centre. The transfer from the airport to the Conference Centre and most of the hotels by taxi takes around 30 min and costs around 20 Euro; you can also use the airport bus to get to the centre of the town. REGISTRATION DESK The desk for registration, information and distribution of documents will remain open at the venue as follows: Thursday, 17 th September 8.00-18.00 Friday, 18 th September 8.00-18.00 Saturday, 19 th September 8.00-18.00 C.M.E. CREDITS Through the C.M.E. division of the Ministry of Health, this meeting has been registered as part of the Italian credit system for medical studies. Credit certificates shall be issued only if the participant has successfully attended the whole meeting and his/her professional qualifications meet the requirements for entitlement to the study credits in question. The C.M.E. credit certificate will be issued only after the candidate has completed and returned the assessment questionnaire at the end of the meeting. 9 LANGUAGE The official language of the Meeting is English. Simultaneous translation will not be provided. LIABILITY AND INSURANCE The organiser is not able to take any responsibility whatsoever for injury or damage involving persons and property during the meeting. Participants are advised to take out their own personal travel and health insurance for their trip. CONGRESS DOCUMENTS AND BADGES The congress documents should be collected on-site at the registration desk at the Conference Centre. Name badges must be worn at all time during the Congress and in the exhibition area.

CERTIFICATE OF ATTENDANCE The certificate of attendance will be collected from the registration desk during the last day of the meeting. COFFEE BREAKS AND LUNCHES Coffee breaks and lunches are included in the registration fee and will be served in the Exhibition Area. HOTEL BOOKINGS The Organising Secretariat is available to provide information regarding hotels and bookings. 10 REGISTRATION FEES (VAT included) Participants to the Conference can choose between two registration fees: an All inclusive registration or a Basic registration. - The All inclusive registration fee includes access to all scientific sessions, the congress bag, the Syllabus, 4 coffee breaks, 3 lunches and 2 or 3 nights at a four-star hotel located at a walking distance from the congress venue. - The Basic registration fee includes access to all scientific sessions, the congress bag, the Syllabus, 4 coffees breaks, 3 lunches. Accommodation and dinners are not included. Basic registration fee e 600,00 includes: Admission to all Scientific Sessions Congress bag Syllabus Coffee breaks and quick lunches Basic registration for young delegates e 350,00 includes: Admission to all Scientific Sessions Congress bag Syllabus Coffee breaks and quick lunches Note: The registration fee will increase by 20% after July 15 th, 2009 The registration fee will increase by 25% on site

CONFERENCE PACKAGES Delegate conference package (2 nights) e 960,00 includes: Basic Registration fee 2 nights in 4 star hotel (breakfast is included) 2 dinners at the hotel restaurant Delegate conference package (3 nights) e 1.200,00 includes: Basic Registration fee 3 nights in 4 star hotel accommodation (breakfast is included) 3 dinners at the hotel restaurant Conference package for young delegates* e 864,00 all inclusive fee includes: Basic Registration fee 3 nights in 3 star hotel accommodation (breakfast is included) 3 dinners at the hotel restaurant * Applicants must be under 35 years at course time and EFSUMB/SIMIT/SIUMB/SIRM/AISF members. Please fax evidence of your student /membership status and identity document reporting date of birth to +39 (0)51 2916933 PAYMENT METHOD Payment will be made by Bank Transfer to FC EVENTI srl IBAN: IT58G0558402409000000000077; BBAN: G0558402409000000000077 Bank charges are the responsibility of the payee 11 CANCELLATION POLICY All cancellations must be notified in writing to the Organising Secretariat. Refunds will be processed after the Congress. Requests for refunds made after the Congress will not be considered Refund of registration fees: cancellations on or before June 15, 2009: 10% will be withheld cancellations between June 15 and August 15, 2009: 30% of the registration fee will be withheld cancellations after August 15: no refund MEETING SECRETARIAT FC EVENTI Srl Vicolo Posterla, 20/2A 40125 Bologna tel. 051.23.68.95 fax 051.29.16.933 e-mail: info@fc-eventi.com

CONTRAST ENHANCED ULTRASOUND IN LIVER, BILIARY, PANCREATIC AND GASTROINTESTINAL DISEASE Gold Sponsors Silver Sponsors

INTERNATIONAL COURSE IN: CONTRAST ENHANCED ULTRASOUND IN LIVER, BILIARY, PANCREATIC AND GASTROINTESTINAL DISEASE Bologna, September 17-19, 2009 Registration Form Name Surname Title Address City Zip Country Tel Mobile Fax number e-mail Fiscal Code (Italians only) Details for Invoice (essential) Name of individual or organization P. IVA: (Italians only) Address Postal Code City Registration Fees: (VAT included) q Euro 600.00 - Basic registration fee q Euro 350.00 - Basic registration for young delegates* q Euro 960.00 - Delegate conference package (2 nights) q Euro 1.200.00 - Delegate conference package (3 nights) q Euro 864.00 - Conference package for young delegates* * Applicants must be under 35 years of age and AISF or SIGE or SIRM or SIUMB members. Please fax evidence of your student status, noting the Congress name to +39 (0)51 2916933 Payment of registration fee should be made only by bank transfer (free of charges): Account holder: FC EVENTI SRL - Bologna-Italy IBAN: IT58G0558402409000000000077 Swift Address: BPMIITM1208 BBAN: G0558402409000000000077 The registration form should be sent with copy of the bank receipt to: FC EVENTI Srl - Vicolo Posterla, 20/2A- 40125 Bologna Tel. +39 (0)51 236895 - Fax +39 (0)51 2916933 E-mail: info@fc-eventi.com