36 / CAP TODAY March 2013 Middleware systems

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1 36 / CAP TODAY March 2013 Part 1 of 5 Abbott Laboratories Beckman Coulter BioMérieux Deborah Anderson [email protected] Sudhish Subhash [email protected] Kesava Nagar-Anthal [email protected] 100 Abbott Park Rd., CP1-4, Abbott Park, IL S. Kraemer Blvd., Brea, CA Rodolphe St., Durham, NC See captodayonline.com/productguides for an interactive version of guide Name of middleware system Instrument Manager (supplied by Data Innovations) Remisol Advance (supplied by Normand-Info SAS) Myla, coagulation instruments, microscope, others microbiology instruments, departmental or total lab automation systems First ever middleware installation/most recent installation* 2007/December /January /November 2011 Last update of middleware system December 2012 November 2012 November 2011 No. of contracts for sites operating middleware ~2, U.S. contracts/foreign contracts (countries) (Canada, Europe, Australia, New Zealand, others) (Canada, France, Germany, Switzerland, others) No. of these contracts signed in calendar-year No. of sites operating middleware/percent of business that is middleware 100+/ 300+/ No. of employees in firm/in middleware development, install, support ~35,000/ ~11,000/ ~6,400/80+ Provide list of client sites to potential customers on request yes (based on the customer s criteria) yes (a list of selected reference sites only) yes (a list of selected reference sites only) Hardware platforms Windows PC, server Dell HP ML350 G6 server Proprietary hardware required no yes (for all versions of middleware) yes (for all versions of middleware) Software platforms Windows 2000 Professional, XP, 2000 server, 2003 Windows server 2008 R2 Windows server 2008 server, 2008 server, Vista, Windows 7 Professional Fault-tolerant solutions/hardware must be purchased from company yes/no yes/yes yes/yes Middleware software or drivers can operate in virtual hardware environment yes no no Databases used or supported InterSystems Caché Microsoft SQL Server 2008 PostgreSQL No. of results/orders that can be stored in database unlimited/unlimited 9,000,000/9,000 up to 10 years worth/ Middleware can interface with instruments from any manufacturer yes no (with Roche, Abbott, Siemens, others) no (with BioMérieux) Types of data middleware can receive, store, transmit alpha numeric, image alpha numeric, image alpha numeric, image No. of instruments one middleware device can support 25 depends on IT configuration; could be unlimited Protocols middleware supports to interface to instruments HL7, ANSI, XML, ASTM, proprietary, others ASTM, proprietary XML, ASTM, proprietary, BCI Low-level transport middleware supports to interface to instruments serial RS232, serial USB, TCP/IP, FTP, LAT serial RS232, TCP/IP, FTP, FXP serial RS232, TCP/IP Middleware can send results to and receive orders from reference labs yes yes yes Sunquest, Meditech, Healthvision, Cerner, Allscripts, GE Healthcare, SCC Soft Computer, others Meditech, McKesson, Sunquest, SCC Soft Computer, Cerner, other systems that support ASTM Sunquest, Cerner, Meditech, Orchard, Siemens, Technidata, Telepath, others Sunquest, Meditech, Healthvision, Cerner, Allscripts, GE Healthcare, SCC Soft Computer, others Meditech, McKesson, Sunquest, SCC Soft Computer, Cerner, other systems that support ASTM Sunquest, Cerner, Meditech, Orchard, Siemens, Technidata, Telepath, others No. of diff. host system connections that can operate at once on middleware unlimited 2 5 Protocols middleware supports to interface to other systems HL7, ANSI, XML, ASTM, proprietary, ODBC ASTM, proprietary, FTP, FXP XML, ASTM, BCI no no no Human languages (other than English) middleware supports most languages French, German Chinese, French, Italian, German, many others Multiple languages can be used at same time on one system yes no yes Middleware supports local date and time formats yes yes yes No. of users that can access middleware at once unlimited 255 unlimited No. of user security levels middleware supports unlimited 3 4 Multiple event actions fired from one if condition statement yes yes no Full and persistent audit trail of rule execution/system supports rules testing yes/yes yes/yes no/no Data from external databases retrieved and incorporated in rules processing yes no no Rules test cases created, saved, used on demand for rules validation testing yes yes no System user notified of rules-based events/notification methods supported yes/pop-up windows, , pager, audio/visual device yes/scrolling event log, pop-up windows, filtered yes/flashing screen, , SMS, light pole window views, color and flag codes Automation routes determined by user-defined rules yes yes no Middleware supports test-based load balancing across instruments yes yes no Events that lead to automation routes being dynamically updated none Laboratory automation system interfaces Abbott, A&T Corp. Beckman Coulter, Olympus America none System allows management of inst. & automation device maintenance records yes yes no System provides alerts when an instrument needs maintenance yes no yes System provides LIS time functions/system allows manual order entry yes/yes yes/yes no/no System generates time specimen ID/Algorithm for ID user definable yes/yes yes/yes no/no Quality control module/interfaces to third-party quality control packages yes/yes (Bio-Rad Unity Real Time, others) yes/yes (Bio-Rad, Thermo Fisher) no/no System supports multi-rule quality control yes yes no System supports moving averages or average of normals yes yes no Users can customize screens/users can define custom fields yes/yes yes/yes yes/yes Users can populate custom fields via user-defined rules yes yes no Screen has image support for any type of image yes no no Users can design own reports/report-generation software used yes/odbc compliant yes/proprietary no/ LOINC can be used to ID tests when communicating with LIS yes yes no Methods by which users can tailor middleware in their own setting dictionary settings dictionary settings Types of system training available/on-site consulting classroom, on-site/yes classroom, on-site, e-learning, user groups/yes on-site, e-learning/yes Smallest cost for hardware/software/annual maintenance Largest cost for hardware/software/annual maintenance Fee for additional users a foundational rule set that can scale to complex, customizable rule development scalability through connectivity to multidepartments, multi-sites, multi-liss, more autoverification, moving averages, other consulting services via implementation and support team integrated extended QC module monitors system operation using patient moving average data, more alerts operator of critical test results; lab s key operators can develop, maintain complex rules on-site customization/implementation services formerly Beckman Coulter DL2000 unique dashboard style; real-time, icon-driven, customizable user interface; integrated middleware specifically for microbiology laboratories; provides real-time quality indicators to monitor key microbiology testing processes Product guide editors: Raymond D. Aller, MD, and Hal Weiner

2 38 / CAP TODAY March 2013 Part 2 of 5 Common Cents Systems Data Innovations Dawning Technologies Carl Barringer [email protected] Sales Department [email protected] Jay Sax [email protected] 4701 Trousdale Drive, Suite 119, Nashville, TN Kimball Ave., Suite 100, South Burlington, VT College Parkway, Suite 202, Fort Myers, FL See captodayonline.com/productguides for an interactive version of guide Name of middleware system Apollo Instrument Manager Instrument Manager JavaLin Interfaces or total lab automation systems microbiology instruments, POC testing instruments, First ever middleware installation/most recent installation* 2001/December /February /January 2013 Last update of middleware system January 2012 March 2013 October 2012 No. of contracts for sites operating middleware 38 3,782 3,400 U.S. contracts/foreign contracts (countries) 37/1 (Trinidad and Tobego) 3,007/775 (in 74 countries) 2,950/450 (in 30+ countries) No. of these contracts signed in calendar-year No. of sites operating middleware/percent of business that is middleware 38/75% 4,213/100% 3,600/100% No. of employees in firm/in middleware development, install, support 11/9 100/47 25/20 Provide list of client sites to potential customers on request yes (a list of all comparable laboratory sites) yes (list of comparable sites, with client approval) yes (a list of all comparable laboratory sites) Hardware platforms Windows PC, Windows server Windows PC, servers, virtualized servers Dawning JavaLin/PDI Proprietary hardware required no no yes (for all versions of middleware) Software platforms Microsoft Windows XP, 7, Windows servers Windows XP, 2003 server, 2008 server (32 bit and 64 Linux OS, Java-based embedded Dawning JResultNet bit), Vista, Windows 7 (32 and 64 bit operating systems) Fault-tolerant solutions/hardware must be purchased from company yes/no yes/no yes/yes Middleware software or drivers can operate in virtual hardware environment yes yes yes Databases used or supported InterSystems Caché, Microsoft SQL InterSystems Caché HSQL, Codebase No. of results/orders that can be stored in database limited only by /limited only by limited only by /limited only by 1,000+/1,000+ Middleware can interface with instruments from any manufacturer yes yes yes Types of data middleware can receive, store, transmit alpha numeric, image, sound alpha numeric, image, TXT reports, PDF, others alpha numeric No. of instruments one middleware device can support limited only by storage and processing capacity unlimited 2 Protocols middleware supports to interface to instruments HL7, XML, ASTM, flat file, CSV multiple HL7, ANSI SQL, XML, ASTM, proprietary, Web services, file import/export, ODBC, others HL7 (all versions below 3.0), ANSI, XML, ASTM, proprietary, CSV, flat file, direct database, others Low-level transport middleware supports to interface to instruments serial RS232, serial USB, TCP/IP, FTP, LAT serial RS232, serial USB, TCP/IP, FTP, ODBC, others serial RS232, serial USB, TCP/IP, FTP, flat file Middleware can send results to and receive orders from reference labs yes (Quest, LabCorp) yes (Quest, LabCorp, ARUP, Mayo Clinic, others) yes (LabCorp, Quest, Specialty Laboratories, AML) Sunquest, GE Healthcare, Siemens, NextGen, eclinicalworks, RioMed Epic, McKesson, Cerner, Siemens, Sunquest, Meditech, GE, Wyndgate, Healthland, others Sunquest, GE Healthcare, Siemens, NextGen, eclinicalworks, RioMed Epic, McKesson, Cerner, Siemens, Sunquest, Meditech, GE, Wyndgate, Healthland, others No. of diff. host system connections that can operate at once on middleware unlimited unlimited unlimited Protocols middleware supports to interface to instruments multiple HL7, ANSI 1238, 1394, XML, ASTM, others multiple HL7, ANSI ODBC/SQL, XML, ASTM, others HL7, ANSI, XML, ASTM, proprietary, CSV, others yes to state and county public health labs yes no Human languages (other than English) middleware supports none all known languages German, French, Spanish, Portuguese, others Multiple languages can be used at same time on one system no yes yes Middleware supports local date and time formats no yes yes No. of users that can access middleware at once unlimited (based on No. of user licenses) unlimited unlimited No. of user security levels middleware supports unlimited unlimited (user defined) unlimited Data from external databases retrieved and incorporated in rules processing yes yes yes Rules test cases created, saved, used on demand for rules validation testing yes yes yes System user notified of rules-based events/notification methods supported yes/pop-up, pager, , color coding of data yes/pop-up windows, , pager, others yes/pop-up windows, , audio alert, others Automation routes determined by user-defined rules yes yes yes Middleware supports test-based load balancing across instruments no yes yes Events that lead to automation routes being dynamically updated none, deletion or revision of test requests and results Laboratory automation system interfaces Roche Beckman, Ortho, Abbott, Roche, Sysmex, others Ortho, Abbott, Roche, Olympus, Siemens, others Middleware interfaces with noninstrument automation devices yes yes yes System allows management of inst. & automation device maintenance records no yes no System provides alerts when an instrument needs maintenance no yes no System provides LIS time functions/system allows manual order entry yes/yes yes/yes yes/yes System generates time specimen ID/Algorithm for ID user definable yes/yes yes/yes yes/yes Quality control module/interfaces to third-party quality control packages yes/no yes/yes (Bio-Rad, Thermo Scientific, others) yes/yes (Bio-Rad) System supports multi-rule quality control yes yes yes System supports moving averages or average of normals yes yes no Users can customize screens/users can define custom fields yes/yes yes/yes yes/yes Users can populate custom fields via user-defined rules yes yes yes Screen has image support for any type of image no yes no Users can design own reports/report-generation software used yes/integrated ad hoc report writer, others yes/any ODBC compliant, internal proprietary yes/crystal Reports LOINC can be used to ID tests when communicating with LIS yes yes Methods by which users can tailor middleware in their own setting scripting, ad hoc query tools scripting, ad hoc query tools, others ad hoc query tools, dictionary settings, others Types of system training available/on-site consulting on-site training, Web training, classroom/yes classroom, on-site, e-learning, Web based/yes classroom, on-site, Web based/yes Smallest cost for hardware/software/annual maintenance /$3,095/$ $2,200/included/$225 Largest cost for hardware/software/annual maintenance /$897,000/$161,460 $5,800/$4,500/$1,185 Fee for additional users $1,650 none integration of pre-analytical, analytical, and postanalytical information into the processing of results multi-site, multi-host, multi-laboratory capability on-site or cloud-based implementation model formerly Common Cents Cirrus Instrument Manager workflow solutions for multiple lab disciplines affecting areas beyond results production affordable for small clinics, yet scalable for large labs intuitive solutions and comprehensive services to support clients and augment available resources distributed processing in a 3-in. 5-in. footprint can add a new instrument on a single connection to the LIS using any standard protocol without disturbing existing connections complete message-mapping control

3 40 / CAP TODAY March 2013 Part 3 of 5 Dawning Technologies HealthBlocks Pathagility Jay Sax [email protected] Justin Langhorst [email protected] Mark McCuin [email protected] 8140 College Parkway, Suite 202, Fort Myers, FL Green Tree Court, Duncanville, TX Executive Center Drive, Suite 100, Little Rock, AR See captodayonline.com/productguides for an interactive version of guide Name of middleware system JResultNet Middleware ENQ AgilityEngine microbiology instruments, POC testing instruments, (to AP LIS), POC testing instruments, molecular/ genomic testing devices First ever middleware installation/most recent installation* 1984/January /December /December 2012 Last update of middleware system July 2012 December 2012 December 2012 No. of contracts for sites operating middleware 2, U.S. contracts/foreign contracts (countries) 1,700/300 (in 30+ countries) 65/15 (Australia, France, Germany, Chile, others) 8/0 No. of these contracts signed in calendar-year No. of sites operating middleware/percent of business that is middleware 2,500/100% 85/100% 15/20% No. of employees in firm/in middleware development, install, support 25/20 8/5 /4 Provide list of client sites to potential customers on request yes (a list of all comparable laboratory sites) no (confidential) yes (a list of all comparable laboratory sites) Hardware platforms platform portable, PCs, Macs, servers, others PCs, enterprise-level servers hardware agnostic Proprietary hardware required yes (for some versions of middleware) yes (for some versions of middleware) no Software platforms Windows 7, 2000, XP Professional, Linux, OS X, others Debian GNU/Linux Python, Windows, Mac, BSD, Solaris, others Fault-tolerant solutions/hardware must be purchased from company yes/no yes/no yes/no Middleware software or drivers can operate in virtual hardware environment yes yes yes Databases used or supported PostgreSQL, HSQL, Codebase, Microsoft SQL, others Microsoft, Oracle, Sybase, Informix, MySQL, others agnostic MySQL, PostgreSQL, SQLite, Oracle No. of results/orders that can be stored in database 1,000+/1,000+ limited only by /limited only by unlimited/unlimited Middleware can interface with instruments from any manufacturer yes yes yes Types of data middleware can receive, store, transmit alpha numeric alpha numeric, image, sound, any binary alpha numeric, image, sound, any file attachment No. of instruments one middleware device can support unlimited 4-5 physical connections, hundreds on network Protocols middleware supports to interface to instruments HL7 (all versions below 3.0), ANSI, ASTM, others HL7 2.x, 3.x, XML, ASTM, proprietary, HPRIM, CSV, BCI HL7 2.x, 3.x, ANSI, XML, ASTM, proprietary, custom Low-level transport middleware supports to interface to instruments serial RS232, serial USB, TCP/IP, FTP, ODBC, flat file serial RS232, serial USB, TCP/IP, FTP, LAT, NFS, others serial RS232, serial USB, TCP/IP, FTP, LAT, others Middleware can send results to and receive orders from reference labs yes (LabCorp, Quest, Specialty Laboratories, AML) no yes Cerner, GE Healthcare, Meditech, Allscripts, Sunquest, McKesson, others Sunquest, Small Business Computers of New England, emds, Allscripts, eclinicalworks, proprietary, others Cerner, GE Healthcare, Meditech, Allscripts, Sunquest McKesson, others Sunquest, Small Business Computers of New England, emds, Allscripts, eclinicalworks, proprietary, others No. of diff. host system connections that can operate at once on middleware unlimited hundreds unlimited Protocols middleware supports to interface to instruments HL7, ANSI, XML, ASTM, proprietary, CSV, others HL7 2.x, 3.x, XML, ASTM, proprietary, HPRIM, CSV, BCI HL7 2.x, 3.x, ANSI, XML, ASTM, proprietary, custom no yes yes Human languages (other than English) middleware supports German, French, Spanish, Portuguese, others none none Multiple languages can be used at same time on one system yes no no Middleware supports local date and time formats yes yes no No. of users that can access middleware at once unlimited 100 unlimited No. of user security levels middleware supports unlimited 1 ~5 Programming or script language required to write rules no yes no Data from external databases retrieved and incorporated in rules processing yes yes yes Rules test cases created, saved, used on demand for rules validation testing yes yes no System user notified of rules-based events/notification methods supported yes/pop-up windows, , audio alert, others yes/ yes/sms, Automation routes determined by user-defined rules yes no no Middleware supports test-based load balancing across instruments yes yes no Events that lead to automation routes being dynamically updated new test requests, reflex test requests, instr. new test requests, reflex test requests, others none Audit trail of route a sample has taken yes yes no Laboratory automation system interfaces Beckman, Ortho, Abbott, Roche, Olympus, others Thermo Scientific Back-end specimen storage and retrieval tracking no yes no System allows management of inst. & automation device maintenance records yes no no System provides alerts when an instrument needs maintenance no no no System provides LIS time functions/system allows manual order entry yes/yes no/no no/yes System generates time specimen ID/Algorithm for ID user definable yes/yes no/no no/no Quality control module/interfaces to third-party quality control packages yes/yes (Bio-Rad) no/no no/no System supports multi-rule quality control yes no no System supports moving averages or average of normals no no no Users can customize screens/users can define custom fields yes/yes no/no no/no Users can populate custom fields via user-defined rules yes no no Screen has image support for any type of image no no yes Users can design own reports/report-generation software used yes/crystal Reports no/ no/ LOINC can be used to ID tests when communicating with LIS yes yes yes Methods by which users can tailor middleware in their own setting ad hoc query tools, dictionary settings, others wraparound programming, dictionary settings wraparound programming, scripting, others Types of system training available/on-site consulting classroom, on-site, Web based/yes e-learning/yes on-site, Web conferencing/yes Smallest cost for hardware/software/annual maintenance /$1,900/$230 /$6,000/$1,250 Largest cost for hardware/software/annual maintenance /depends on number of interfaces/depends on $1,000/$6,000 No. of bi-directional connections/ number of interfaces $1,250 No. of bi-directional connections Fee for additional users none none Cost for cloud-based or similar products/services $2,500+ start-up cost/$5,000+ annual maintenance or usage fee/$500+ monthly subscription fee scalable solutions, from single instrument to enterprise-level middleware comprehensive rules development kit increases autoverification and reduces turnaround time with rules and calculations libraries configured so it arrives at user s door ready to connect and integrate rapid development of message formats and protocols can be done on request solves complex integration problems adds flexibility to the client s system environment via its architecture and multiple deployment options on-demand deployment cost effective; low overhead

4 42 / CAP TODAY March 2013 Part 4 of 5 Roche Siemens Healthcare Diagnostics Siemens Healthcare Diagnostics Aime Chidester [email protected] Sharon Etzman [email protected] Sharon Etzman [email protected] 9115 Hague Rd., Indianapolis, IN Deerfield Rd., Deerfield, IL Deerfield Rd., Deerfield, IL See captodayonline.com/productguides for an interactive version of guide Name of middleware system Roche Middleware Solutions CentraLink Syngo Lab Data Manager POC testing instruments, departmental or total lab automation systems, others First ever middleware installation/most recent installation* 1998/January /January /January 2013 Last update of middleware system December 2012 December 2012 July 2011 No. of contracts for sites operating middleware U.S. contracts/foreign contracts (countries) 585/0 309/509 (worldwide) 122/35 (France, Australia, Canada, Portugal, others) No. of these contracts signed in calendar-year No. of sites operating middleware/percent of business that is middleware 585/ 818/<5% 157/<5% No. of employees in firm/in middleware development, install, support 4,200 (centralized diagnostics)/55 51,000/400 51,000/400 Provide list of client sites to potential customers on request yes (a list of selected reference sites only) yes (a list of all comparable laboratory sites) yes (a list of selected reference sites only) Hardware platforms Dell OptiPlex 7010, Dell PowerEdge T620 tower chassis, Dell PowerEdge R620 rack mount, other Dell dedicated computing high-capacity server, dedicated computing standard-capacity server dedicated computing high-capacity server, dedicated computing standard-capacity server Proprietary hardware required yes (for some versions of middleware) yes (for all versions of middleware) yes (for all versions of middleware) Software platforms Windows 7, Windows server 2008 R2 (64 bit) Windows server 2003, Windows XP Windows server 2008 Fault-tolerant solutions/hardware must be purchased from company yes/no yes/yes yes/yes Middleware software or drivers can operate in virtual hardware environment yes no no Databases used or supported InterSystems Caché OpenEdge Microsoft SQL server 2008 R2 No. of results/orders that can be stored in database limited only by storage/limited only by storage up to 40,000,000/960,000 23,040,000/7,000,000 Middleware can interface with instruments from any manufacturer no (with numerous manufacturers instruments) yes no (with Siemens) Types of data middleware can receive, store, transmit alpha numeric, image, other binary alpha numeric, image alpha numeric No. of instruments one middleware device can support up to Protocols middleware supports to interface to instruments HL7, XML, ASTM, ODBC, SQL, http HL7 2.5, ANSI 1394, ASTM, proprietary ANSI LIS1A, LIS2A (old standard E ), ASTM Low-level transport middleware supports to interface to instruments serial RS232, TCP/IP, FTP serial RS232, TCP/IP, FTP serial RS232, TCP/IP Middleware can send results to and receive orders from reference labs no no no McKesson, Sunquest, Cerner, SCC Soft Computer, Meditech, homegrown LIS, others Antek, Sunquest, Aspyra, Apex, GE, Cerner, McKesson, SCC Soft Computer, Meditech, others Siemens, Cerner, Meditech, Sunquest, SCC Soft Computer, others McKesson, Sunquest, Cerner, SCC Soft Computer, Meditech, homegrown LIS, others Antek, Sunquest, Aspyra, Apex, GE, Cerner, McKesson, SCC Soft Computer, Meditech, others Siemens, Cerner, Meditech, Sunquest, SCC Soft Computer, others No. of diff. host system connections that can operate at once on middleware unlimited multiple 1 Protocols middleware supports to interface to instruments HL7, XML, ASTM HL7 2.5, ANSI 1394, ASTM, Technidata LMX 6.0 ANSI LIS1A, LIS2A (old standard E ), ASTM no no Human languages (other than English) middleware supports none Spanish, French, Italian, German, Dutch French, Italian, German, Spanish Multiple languages can be used at same time on one system no yes no Middleware supports local date and time formats no yes yes No. of users that can access middleware at once unlimited No. of user security levels middleware supports unlimited (user defined) 4 3 Programming or script language required to write rules no no yes Full and persistent audit trail of rule execution/system supports rules testing yes/yes yes/yes yes/ Data from external databases retrieved and incorporated in rules processing yes no no Rules test cases created, saved, used on demand for rules validation testing yes yes yes System user notified of rules-based events/notification methods supported yes/pop-up, , audio/visual yes/pop-ups, color cues, log files yes/visual notifications Automation routes determined by user-defined rules yes yes yes Middleware supports test-based load balancing across instruments yes yes yes Events that lead to automation routes being dynamically updated, QC performance, reagent inventory, test priority Laboratory automation system interfaces Roche Siemens Siemens System allows management of inst. & automation device maintenance records yes no no System provides alerts when an instrument needs maintenance yes no no System provides LIS time functions/system allows manual order entry yes/yes yes/yes yes/yes System generates time specimen ID/Algorithm for ID user definable yes/yes yes/yes no/no Quality control module/interfaces to third-party quality control packages no/yes (Bio-Rad, Thermo Fisher) yes/yes (Bio-Rad) yes/yes (Bio-Rad) System supports multi-rule quality control yes yes yes System supports moving averages or average of normals yes yes yes Users can customize screens/users can define custom fields yes/yes yes/yes no/no Users can populate custom fields via user-defined rules yes yes no Screen has image support for any type of image yes no no Users can design own reports/report-generation software used yes/any ODBC compliant yes/text, html yes/jasper LOINC can be used to ID tests when communicating with LIS yes yes no Methods by which users can tailor middleware in their own setting dictionary settings, user-configurable workspaces, ad hoc query tools, dictionary settings, rules, site ad hoc query tools customizable user security functions, filters Types of system training available/on-site consulting Web-based courses, classroom, others/yes on-site, e-learning/yes on-site, e-learning/yes Smallest cost for hardware/software/annual maintenance Largest cost for hardware/software/annual maintenance Fee for additional users mature middleware vendor; over 15 years supplier partnership with Data Innovations pre-fabricated rules package designed specifically for Roche analyzers multi-faceted customer-to-customer information sharing on middleware best practices comprehensive result-management and autoverification rules and integrated QC package highly customizable workflow scenarios robust and mature multi-discipline datamanagement and networking solution integrated quality control monitoring with patient result management

5 44 / CAP TODAY March 2013 Part 5 of 5 Sysmex America Sysmex America Technidata America Medical Software Tammy Kutz [email protected] Tammy Kutz [email protected] Yves Charron [email protected] 577 Aptakisic Rd., Lincolnshire, IL Aptakisic Rd., Lincolnshire, IL De Gaspé Ave., Ste. 223, Montreal H2S 2X3 Canada See captodayonline.com/productguides for an interactive version of guide ext Name of middleware system Sysmex WAM WAM Select TD-Harmony, tube sorter, digital cell morphology systems chemistry/hematology/immunology lab instruments or total lab automation systems, genetics, biobanking First ever middleware installation/most recent installation* 2003/December /December /December 2012 Last update of middleware system August 2011 October 2011 December 2012 No. of contracts for sites operating middleware U.S. contracts/foreign contracts (countries) 209/14 (Canada) 13/0 unknown/unknown (Canada, France, Spain, Italy, others) No. of these contracts signed in calendar-year No. of sites operating middleware/percent of business that is middleware 776/20% 13/20% unknown/15% No. of employees in firm/in middleware development, install, support 724/ / /130 Provide list of client sites to potential customers on request yes (a list of selected reference sites only) yes (a list of selected reference sites only) yes (a list of selected reference sites only) Hardware platforms Red Hat Linux Windows any that support Microsoft Windows Proprietary hardware required no yes (for all versions of middleware) no Software platforms Compuware Uniface Microsoft Microsoft Windows, Linux, Unix Fault-tolerant solutions/hardware must be purchased from company yes/no no/yes yes/no Middleware software or drivers can operate in virtual hardware environment yes no yes Databases used or supported Oracle SQL SQL server 2012, Oracle v. 11 No. of results/orders that can be stored in database 2 years worth/2 years worth 90 days worth/90 days worth unlimited/unlimited Middleware can interface with instruments from any manufacturer no (with Sysmex, Bio-Rad, CellaVision) no (with Sysmex hematology analyzers) yes Types of data middleware can receive, store, transmit alpha numeric, image alpha numeric, image alpha numeric, image No. of instruments one middleware device can support unlimited across multiple sites 2 4,000 Protocols middleware supports to interface to instruments HL7 2.4, ANSI E1394, proprietary ASTM, proprietary HL7, ANSI, XML, ASTM, proprietary, HPRIM Low-level transport middleware supports to interface to instruments serial RS232, serial USB, TCP/IP serial RS232, serial USB, TCP/IP serial RS232, serial USB, TCP/IP, FTP, LAT, file sharing Middleware can send results to and receive orders from reference labs no no yes (Labquest, LabCorp, Dynacare, LifeLabs, Mayo) Epic, Sunquest, Cerner, Meditech, McKesson, Siemens, Sunquest, Meditech, CPSI, Orchard Meditech, Cerner, Keane, Stemsoft, Sunquest, others QuadraMed, SCC Soft Computer, Diamond, others Epic, Sunquest, Cerner, Meditech, McKesson, Siemens, Sunquest, Meditech, CPSI, Orchard Meditech, Cerner, Keane, Stemsoft, Sunquest, others QuadraMed, SCC Soft Computer, Diamond, others No. of diff. host system connections that can operate at once on middleware unlimited 1 4,000 Protocols middleware supports to interface to instruments HL7 2.4, ANSI E1394, ASTM, proprietary ASTM, proprietary HL7 2.x, ANSI, XML, ASTM, proprietary, HPRIM no no yes (in United Kingdom and Canada) Human languages (other than English) middleware supports none French, Spanish French, Spanish, Dutch, German, Italian, others Multiple languages can be used at same time on one system no no yes Middleware supports local date and time formats yes no yes No. of users that can access middleware at once unlimited 1 unlimited (but hardware dependent) No. of user security levels middleware supports unlimited 2 unlimited Rule sets applied to individual instruments or connections yes no yes Data from external databases retrieved and incorporated in rules processing no no no Rules test cases created, saved, used on demand for rules validation testing no yes no System user notified of rules-based events/notification methods supported yes/pop-up, audio/visual yes/pop-up, audio/visual yes/ , SMS, printout Automation routes determined by user-defined rules yes no yes Middleware supports test-based load balancing across instruments yes no yes Events that lead to automation routes being dynamically updated new test requests, reflex test requests, instr. none new test requests, reflex test requests, instr. Audit trail of route a sample has taken yes no yes Laboratory automation system interfaces Sysmex Beckman, Roche, Ortho, Abbott, Olympus, others Middleware interfaces with noninstrument automation devices yes no yes Back-end specimen storage and retrieval tracking yes no yes System allows management of inst. & automation device maintenance records no no yes System provides alerts when an instrument needs maintenance no no no System provides LIS time functions/system allows manual order entry yes/yes no/no yes/yes System generates time specimen ID/Algorithm for ID user definable no/yes no/yes yes/yes Quality control module/interfaces to third-party quality control packages yes/no no/no yes/yes (Bio-Rad) System supports multi-rule quality control yes no yes System supports moving averages or average of normals yes no yes Users can customize screens/users can define custom fields no/yes no/no yes/no Users can populate custom fields via user-defined rules yes no no Screen has image support for any type of image yes yes yes Users can design own reports/report-generation software used no/ no/ yes/proprietary, Crystal Reports LOINC can be used to ID tests when communicating with LIS no no yes Methods by which users can tailor middleware in their own setting dictionary settings dictionary settings wraparound programming, scripting, ad hoc query tools, user-defined interfaces, dictionary settings Types of system training available/on-site consulting classroom, virtual, on-site, e-learning/yes e-learning/yes e-learning, on-site, classroom (on demand)/yes Smallest cost for hardware/software/annual maintenance $500/$4,000/$800 Largest cost for hardware/software/annual maintenance $40,000/$350,000/$70,000 Fee for additional users $2,000 flexible rule engine with extensive rule-variable combinations for building rules for autovalidation, reflexing, add-on testing, specimen aging, more management reports module provides real-time data mining proactive alert-monitoring system formerly Sysmex Molis WAM hematology-specific rules that help labs achieve greater than 85 percent autovalidation rates designed for small to medium-sized labs allows users to easily and independently manage decision rules in hematology ability to cover all clinical and anatomic pathology disciplines push information system new and painless way to go from a legacy LIS to a middleware solution and then to a new LIS

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