58th ANNUAL MEETING OF THE ITALIAN CANCER SOCIETY REVOLUTIONARY ROAD. VERONA SEPTEMBER Palazzo della GRAN GUARDIA. Preliminary Program

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1 SEPTEMBER Palazzo della GRAN GUARDIA Preliminary Program

2 Scientific Coordinators Davide Melisi (Verona) Giampaolo Tortora (Verona) Scientific Program Monday, September 5 th 13:30 Registration Local Scientific Committee Vincenzo Bronte (Verona) Carmine Carbone (Verona) Geny Piro (Verona) Raffaela Santoro (Verona) Aldo Scarpa (Verona) Welcome opening Opening lecture Mechanisms of Resistance to Endocrine Therapy: Insights from Translational Studies in Breast Cancer Carlos L. Arteaga (USA) Coffee break SIC Secretariat Società Italiana di Cancerologia Via G. Venezian, Milano MI sic@istitutotumori.mi.it Organizing Secretariat Via Sassonia, Rimini RN sic2016@adriacongrex.it SIC Scientific Board President Silvia Giordano (Turin) President Elect Gabriella Sozzi (Milan) Board Rita Falcioni (Rome) Davide Melisi (Verona) Nicola Normanno (Naples) Massimo Santoro (Naples) Elda Tagliabue (Milan) Giulia Taraboletti (Bergamo) Giuseppe Viglietto (Catanzaro) Member under 35 Marco Macagno (Turin) Selena Ventura (Bologna) Past President Riccardo Dolcetti (Aviano-PN) Pancreatic cancer Claudio Bassi (Italy) Andrew V. Biankin (UK) Kras, IL-1alpha, NF-kappaB, and Inflammation: Dangerous Liaisons Paul J. Chiao (USA)

3 Tuesday, September 6 th Metabolism and cancer Antiangiogenic therapy and metabolic evolution of tumors Stefano Indraccolo (Italy) Shutting your TRAP to kill tumors? The oncogenic role of the mitochondrial chaperone TRAP1 Andrea Rasola (Italy) Clinical cancer genomics and heterogeneity Lunch A Dynamic Episomal Basis for Therapeutic Resistance Webster K. Cavenee (USA) Colorectal cancer molecular heterogeneity: from patients to preclinical models, and back Enzo Medico (Italy) Poster viewing with authors Poster Discussion (2 parallel sessions) Poster Discussion (2 parallel sessions) Coffee break Epigenetics/Non coding RNA Role of exosomic micrornas in the biology of the Tumor Microenvironment Muller Fabbri (USA) Yap/Taz at the roots of cancer Stefano Piccolo (Italy) Wednesday, September 7 th Tumor microenvironment Breaking Bad: cancer associated fibroblasts are reprogrammed from growth inhibitory to tumor-promoting in breast Neta Erez (Israel) Fgf-trap Molecules For Cancer Therapy Marco Presta (Italy) SIC meets Pharma Industry Lunch Joint meeting SIC-ESMO: New combination strategies Michele Milella (Italy) To be defined Coffee break Evolving intratumor heterogeneity in glioblastoma Joan Seoane (Spain) Cancer precision medicine in colorectal cancer: Opportunities and challenges Livio Trusolino (Italy) Poster viewing with authors Cancer immunotherapy Mechanisms of response and resistance to immune checkpoint blockade in solid tumors Andrea Anichini (Italy) Vincenzo Bronte (Italy) RNA based cancer immunotherapy Ugur Sahin (Germany)

4 Abstract Thursday, September 8 th New targets / New models Vincenzo Cerullo (Finland) The dependence receptor paradigm: from an alternative cell death pathway to novel drugs entering clinical trials Patrick Mehlen (France) Giorgio Prodi Lecture Award ceremony Piero Trivella awards for the best posters Guido Berlucchi Foundation awards for the best posters Guido Berlucchi Foundation award for the best oral presentation Elena Cappannini award for the best 2015 publication Pezcoller Foundation scholarship winner award Pezcoller Foundation scholarship award Closing lecture Giorgio Trinchieri (USA) 14:00 Closing remarks Abstract submission The organizers invite authors to submit abstracts for consideration and inclusion in the programme. Abstracts must be sent by May 2, 2016 and must focus on the following topics: Animal models of cancer Autophagy, apoptosis, necrosis and senescence Cancer genetics, genomics and epigenetics Cancer modeling and imaging Cancer stem cells Carcinogenesis Cell adhesion, migration, invasion and metastasis Cell metabolism Chemoprevention and early detection DNA damage and molecular responses to damage Drug resistance Experimental therapeutics Molecular and genetic epidemiology Molecular pathology Nanotechnology Non-coding RNAs Novel therapeutic targets Oncogenes and tumor suppressor genes Personalized medicine Prognostic and predictive biomarkers Signal transduction and intracellular trafficking System biology and OMICS technologies Tumor heterogeneity Tumor immunology and immunotherapy Tumor microenvironment: inflammation, hypoxia and angiogenesis Abstracts must be written in English and must not exceed characters (including blanks and excluding the title and the authors). All submitted abstracts will be reviewed by a Scientific Committee and selected for oral or poster presentations (sizes: cm 70x100h.). Abstracts must be sent using the online form. Abstracts sent in any other way will not be accepted. Notification of acceptance or rejection, together with information about session, date, time and type of presentation, will follow. Each Author can present only one abstract. Abstracts will be included in the Programme and in the Abstract book only if the Presenting Author will be regularly registered in the Congress.

5 th 58 September Palazzo della GRAN GUARDIA General Information Registration Fees Early registration Late registration On-site by June 15, 2016 by August 25, 2016 registration SIC MEMBER* 360,00 410,00 450,00 NON SIC MEMBER** 460,00 510,00 550,00 SIC MEMBER UNDER 35* 210,00 260,00 280,00 NON SIC MEMBER UNDER 35** 270,00 330,00 360,00 (*)VAT non applicable as for law ex Art.4 DPR 633/72; (**) VAT 22% included The VAT rate will be applied depending on the Italian fiscal law at the time of payment. Registration fees include: admission to the scientific sessions admission to the exhibition area name badge and congress kit abstracts book attendance certificate ECM certificate welcome cocktail, coffee breaks, light lunches and social dinner Registrations can be requested submitting the registration form online: Fax Registrations without payment will not be accepted. Payment Methods and Details Payment should be made by one of the following methods: Bank transfer Please transfer the payment to Adria Congrex Bank details: IT 18 N CC The payment transfer form should clearly state SIC 2016 Code AMVE and the name(s) of the delegate(s). Credit card All major credit cards are accepted (American Express, VISA, Mastercard, Cartasi). REGISTRATIONS WILL BE PROCESSED ONLY WHEN ACCOMPANIED BY THE TOTAL PAYMENT. Cancellation In case of cancellation reimbursement will not be done.