2011 IRCC International Conference Molecular Clinical Oncology May 26th-28th, 2011, Torino Italy

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1 Updated May 23rd, IRCC International Conference Molecular Clinical Oncology May 26th-28th, 2011, Torino Italy Thursday May 26 th, 2011 (afternoon) Venue: Aula Magna Rettorato Registration Session 1. Cancer Stem Cells PierGiuseppe Pelicci (IFOM-IEO Campus, Milano- Italy) Regulation of Self Renewal in Cancer Stem Cells John Laterra (Kennedy Krieger Institute, Johns Hopkins School of Medicine, Baltimore- USA) Regulation of Glioblastoma Stem Cells: Reprogramming Factors and Receptor Tyrosine Kinases Elisa Vigna (Institute for Cancer Research, University of Torino, Candiolo- Italy) Targeted Therapy of Glioblastoma by Gene Transfer of a Monovalent Antibody against the MET Oncogene Coffee break Welcome Address by Institutional Representatives Opening Remarks Paolo Comoglio (Institute for Cancer Research, University of Torino, Candiolo- Italy) Molecular Clinical Oncology: a Novel Discipline AIRC Lecture Jeffrey A Engelman (Massachusetts General Hospital Cancer Center, Charlestown- USA) Cancer Targeted Therapy Welcome Reception

2 Friday May 27 th, 2011 (morning) Session 2. Cancer Genes Pier Paolo Pandolfi (Beth Israel Deaconess Medical Center, Boston- USA) Deconstructing the Molecular Genetics of Cancer David B Solit (Memorial Sloan Kettering Cancer Center, New York- USA) Genetic Determinants of RAS/BRAF-dependence Richard Marais (The Institute of Cancer Research, London- United Kingdom) BRAF and RAS Signalling in Melanoma: Basic Biology and Therapeutic Intervention Coffee break Ken Olaussen (Institut Gustave Roussy, Villejuif Cedex- France) Targeting DNA Repair Dysfunctionality in Lung Cancer Livio Trusolino (Institute for Cancer Research, University of Torino, Candiolo- Italy) MET in Human Cancer: Targeting Oncogene Addiction and Expedience Kristiina Iljin (Medical Biotechnology, VTT Technical Research Centre, Turku-Finland) Identification of Novel Therapeutic Strategies to Target ERG Oncogene Positive Prostate Cancer Charlotte Gueydan (Hôpital Tenon, Paris- France) A Genome-Wide Screen for Renal Cancer Genes by Targeted Transposon-Mediated Mutagenesis in Vivo Lunch

3 Friday May 27 th, 2011 (afternoon) Poster Session A: even numbers Session 3. Molecular Diagnosis and Prognosis Ian Tomlinson (Wellcome Trust Centre for Human Genetics, Oxford- UK) Predisposition to Colorectal and Other Cancers Sabine Tejpar (University Hospital Gasthuisberg, Leuven- Belgium) Molecular Subgroups in Colorectal Cancer: Prognostic and Predictive Implications Roberto Labianca (Ospedali Riuniti, Bergamo- Italy) Prognostic and Predictive Biomarkers for Colorectal Cancer in the Adjuvant Setting Coffee break Pierre Laurent-Puig (Université Paris-Descartes, Paris- France) Theranostic Biomarkers in Metastatic Colorectal Cancer Serena di Cosimo (Vall d'hebron University Hospital, VHIO, Barcelona- Spain) Introduction of Biomarkers in Early Clinical Development Social Event

4 Saturday May 28 th, 2011 (morning) Session 4. Personalized Cancer Therapies: Concepts and Targets Giorgio Scagliotti (University of Torino School of Medicine, Orbassano - Italy) Tailoring Chemotherapy in NSCLC William Sellers (Novartis Institutes for BioMedical Research, Cambridge- USA) The Genetic Basis for Cancer Therapeutics Federico Cappuzzo (Istituto Toscano Tumori, Livorno- Italy) Anti-EGFR Strategies against Metastatic NSCLC Coffee break Karen Gelmon (BC Cancer Agency, Vancouver- Canada) Hypothesis Driven Trials in Breast Cancer Alberto Bardelli (Institute for Cancer Research, University of Torino, Candiolo- Italy) Cancer Mutations and Targeted Therapies in Cells, Mice and Patients Manuela Ferracin (University of Ferrara, Italy) MicroRNA Profiling for the Identification of Cancers with Unknown Primary Tissue-of-Origin Davide Melisi (INT Fondazione Pascale, Napoli-Italy) Anti-VEGF Treatment Resistant Pancreatic Cancers Secrete not Alternative Proangiogenic but Rather Proinflammatory Factors that Induce an EMT phenotype Lunch

5 Saturday May 28 th, 2011 (afternoon) Poster Session B: odd numbers Session 5. Personalized Cancer Therapies: Overcoming Resistances William Pao (Vanderbilt University, Nashville- USA) Novel Strategies to Delay/Treat Acquired Resistance to EGFR TKIs in EGFR Mutant Lung Cancer Pasi A. Janne (Dana-Farber Cancer Institute, Boston- USA) Therapeutic Strategies for EGFR Kinase Inhibitor Resistant Cancers Fortunato Ciardiello (Second University, Napoli- Italy) Acquired Resistance to EGFR-targeted Therapies Salvatore Siena (Ospedale Niguarda Ca' Granda, Milano- Italy) Molecular Driven Selection Improves Survival of Metastatic Colorectal Cancer Patients Gianmarco Contino (Massachusetts General Hospital Cancer Center, Boston- USA) STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis Marianna Sasso (Istituto Nazionale dei Tumori, Milano-Italy Wound-healing drainages fluids promote triple negative breast cancers progression through endothelial receptors activation ECM verification test

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