VII MEETING OF MOLECULAR ONCOLOGY

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1 VII MEETING OF MOLECULAR ONCOLOGY Gruppo di Oncologia Molecolare - SIC POSITANO, MAY 14-17, 2007 Hotel Le Agavi Sponsored by: FIRC - Fondazione Italiana per la Ricerca sul Cancro NOGEC - Naples Oncogenomic Center Università degli Studi di Catanzaro Magna Graecia IFOM - Istituto FIRC di Oncologia Molecolare Dottorato Internazionale di Oncologia Dipartimento di Biologia e Patologia Cellulare e Molecolare-Napoli Università degli Studi di Napoli Federico II Istituto Superiore di Oncologia - Genova CEINGE - Biotecnologie Avanzate Istituto di Endocrinologia ed Oncologia Sperimentale del CNR - Napoli

2 It is a great satisfaction for us to announce the VII Meeting of Molecular Oncology which will be held again in Positano. As in the past, this meeting will be organized under the Patrocinium of the Società Italiana di Cancerologia (SIC). Since also the last meeting, held in Positano in 2005, was successful for the number of participants and the scientific level of the presentations, we have not modified the style of the meeting. Therefore, to underline the international character of this meeting and to promote further scientific collaborations between Italian and foreign research groups, we have kept the English language as the official language of the meeting and we have invited several outstanding foreign researchers. We have introduced this year a session dedicated to the Cancer Epigenetics that will, likely, represent the next challenge of the cancer investigations. Moreover, a session will be dedicated to the role of the micrornas in development and cancer: it represents nowadays a subject that is attracting several researchers. Also the studies regarding the isolation and characterization of the cancer susceptibility genes, another important novel and fascinating field of cancer research, will have large space in the meeting. Great attention will be again given to young researchers. In fact, more than twenty posters will be selected for oral presentation and discussed during the general sessions. The meeting is supported by the Fondazione Italiana per la Ricerca sul Cancro.

3 Preliminary Scientific Program Monday, May 14 Afternoon Development and Stem Cancer Cells Stefano Piccolo Padua, Italy New players in TGF-β signaling M V Lohuizen Amsterdam, Netherlands Polycomb repressors controlling stem cell fate: Implications for cancer and development Antonio Simeone Naples, Italy Otx genes in neurogenesis and lymphopoiesis Ruggero De Maria-Rome, Italy Cancer stem cells from solid tumors: new prognostic and therapeutic tools Pier Giuseppe Pelicci Milan, Italy Biological differences between normal and cancer stem cells Tuesday May 15 Morning Cancer Genetics Ronald de Pinho Boston, USA Genomics and biology of GBM Aldo Scarpa Verona, Italy Molecular pathology of pancreatic cancer Alfredo Fusco Naples, Italy The CBX7 gene plays a critical role in tumor progression Scott Hammond Cold Spring Harbor, USA RNAi, micrornas and human diseases Carlo Maria Croce Columbus OH, USA MicroRNAs in chronic leukemia Poster Exhibition MicroRNAs in Development and Cancer Afternoon Growth Receptors and Transduction in Normal and Cancer Cells Pier Paolo Di Fiore Milan, Italy Endocytosis conducts the cell signaling orchestra Paolo Comoglio Turin, Italy The MET oncogene: control of invasive growth in cancer and stem cells Michael Caligiuri Columbus, USA The role of IL-15 in NK cell development and NK cell leukemia Giorgio Scita Milan, Italy Coordination of trafficking and actin dynamics regulates cell shape changes and cell migration Webster Cavenee San Diego, USA Receptor driven tumor maintenance and heterogeneity

4 Wednesday May 16 Morning Gene susceptibility to cancer Allan Balmain, San Francisco USA Cancer stem cell fate decisions and cancer susceptibility Ashok Venkitaraman Cambridge, UK Models for inherited cancer susceptibility Mariano Barbacid Madrid, Spain Ras Genes, Ras Oncogenes and Cancer Afternoon Cell cycle and Cancer Epigenetics Michele Pagano New York, USA SCF ligases: deregulated cell cycle control and proteolysis in cancer Manel Esteller Madrid, Spain The epigenome of cancer cell Vittorio Enrico Avvedimento Naples, Italy Coupling oxidation to transcription : estrogen induced transcription is driven by local histone H3 demethylation and a nuclear oxidative burst Giulio Draetta -Boston, USA Notch pathway inhibitors as anti-cancer agents Thursday May 17 Morning Innovative Cancer Therapy Lucia Altucci Naples, Italy New challenges for cancer treatment: impact of epigenetic drugs Henrich Gronemeyer Strasbourg, France Three paradigms of apoptosis induction by retinoids and rexinoids: Towards tumor cellselective, apoptogenic therapies Marco A. Pierotti Milan, Italy The promises of targeted therapies and the challenges of the intrinsic and acquired resistance Massimo Santoro Naples, Italy Ret inhibitors in the therapy of thyroid medullary carcinomas Silvia Giordano Turin, Italy Cancer therapy: can the challenge be MET? Anna Biroccio Rome, Italy G-quadruplex DNA as target for telomere-directed molecular cancer therapeutics End Of The Meeting

5 Place Le Agavi Hotel - Sala Convegni - Via G. Marconi - Belvedere Fornillo Positano - Salerno Phone: Fax: General Information How to get to Positano: By car: for people coming from the North: take Autostrada del Sole (A-1) to Naples. Then, follow the directions Napoli-Salerno - Reggio Calabria; take this motorway and exit at Castellammare di Stabia from where, following the street signs, you will reach Positano; for people who come from the South: take the Autostrada Reggio Calabria Salerno-Napoli and exit at Castellammare di Stabia from where, following the street signs, you will reach Positano. By train: the railroad station we advise you, is the Central Station of Naples or the one of Garibaldi Square (Piazza Garibaldi Station), which is located at a lower level below Naples Central Station. From either of the two stations follow the directions for the Circumvesuviana trains (walking distance). Take Circumvesuviana to the Sorrento Station. From there, take a bus to Positano, which is parked in the square outside the Sorrento Station. By air: for people who arrive at Capodichino Airport: take a taxi or the airport bus to the Circumvesuviana Station and there take the train to Sorrento. By sea: with the metro del mare, a ship that brings you from Naples to the coast. See information at By congress bus: the bus service (offered by the congress) from the Airport and from the Central Station of Naples is planned for the morning of May 14 to get to Positano and for the afternoon of May 17 to get to Naples. Registration The enclosed registration form must be completed and sent to the organizing secretariat - APRO - Via Francesco Cilea, Napoli - before February 28, together with the certification of the payment of the registration fee. Payment can be made by bank cheque payable to APRO or by a bank money transfer to APRO at the: Banca della Campania BIC: IRPBIT3A CIN: H ABI: CAB: C/C: IBAN: IT08H Registration Fee The registration fee is 400,00. For the participants under 30 years the registration fee is 300,00. It entitles you to participate at the congress scientific sessions and receive the congress kit which includes: the abstracts book; coffee-breaks; lunches at Le Agavi Hotel on May 15 and 16 (Tuesday and Wednesday); bus service from Naples Airport or Central Station to Positano and vice versa. Language The official language will be English. Posters Abstracts and posters must be written in English. Posters can be exhibited in the inner hall next to the congress hall on Monday May 14 from 2.00 p.m. Authors are invited to be present at the posters on Tuesday afternoon May 15 from 2.00 to 4.00 p.m. at the terrace of Le Agavi Hotel. In case of rain, the poster exhibition will be held in the congress hall. The poster board dimensions are 90 cm x 90 cm. Abstracts must be sent to the following address: apro_a@hotmail.com The authors are asked to adhere to the following instructions:

6 - the abstract must contain a maximum of 3000 characters; - each abstract should include a title (in capital letters), the names of all the authors, with the initial of the first name followed by the last name (Ex: J. Smith) and institutional affiliation; - the name of the author who will present the paper must be underlined; - the summary must contain the aim of the paper, the methods, the results and the conclusions; - the abbreviations must be put into brackets and, when they appear for the first time in the summary, they must be written in extenso; - the abstract must be typed single-spaced; - type in MS Word. Almost 20 posters will be selected for a short oral presentation (8 minutes). For oral presentation young researchers (under 35 years of age) will be preferred. The participants will be informed about the above mentioned selection within April 15, Each participant is allowed to present only one poster. Hotels The participants who wish to reserve a room must complete the attached hotel booking form and return it to the organizing secretariat. The organizing secretariat does not get any money for hotel reservations and the invoices are directly given by the hotels. Accomodation for young researchers About twenty double bedrooms are available at La Bougainville Hotel and at the La Florida Residence for participants who are younger than 35 years of age. This hotel accommodation service, offers several comfortable and cheap double-rooms. This kind of accommodation is not available for the accompanying persons. Attendance certificate and receipt of payment At the end of the meeting all participants will receive an attendance certificate and the receipt of payment. Excursions From Positano you can get to the following touristic places: by Sea: Capri, Ischia and Procida islands; to West: Sorrento, Pompei, Ercolano, the Vesuvio, Pozzuoli; to East: Amalfi, Ravello, Vietri sul Mare, Salerno, Paestum. The number of the participants will be limited to 120 The deadline for registration is February 28, 2007 Alfredo Fusco: afusco@napoli.com V. Enrico Avvedimento : avvedim@unina.it Giancarlo Vecchio: vecchio@unina.it Dipartimento di Biologia e Patologia Cellulare e Molecolare Facoltà di Medicina e Chirurgia di Napoli Phone: Fax: Salvatore Venuta: venuta@unicz.it Giuseppe Viglietto: viglietto@unicz.it Facoltà di Medicina e Chirurgia di Catanzaro Phone: ; Fax: Lorenzo Chiariotti: chiariot@unina.it Università degli Studi del Molise Scientific Committee Pier Paolo Di Fiore: difiore@ifirc-ifom.it Istituto FIRC di Oncologia Molecolare Phone: or 257; Fax: Marco A. Pierotti: pierotti@istitutotumori.mi.it Istituto dei Tumori di Milano Phone: ; Fax: Organizing Secretariat APRO - Associazione Partenopea Ricerche Oncologiche Via Cilea Napoli Phone/Fax: apro_a@hotmail.com

7 Registration Form Please type or use block capitals and send to the organizing secretariat by February 28, Title Name Age: _ Institution/Affiliation _ Institution address City _ State Postal Code _ Country _ Phone Fax _ _ Accompanied by _ ( ) I enclosed a bank cheque of 300,00 (under 30 years old) ( ) I enclose a bank cheque of 400,00 The number of the cheque is _ The bank is _ The cheque should be not transferable and payable to APRO ( ) I made a bank money transfer of 300,00 (under 30 years old) ( ) I made a bank money transfer of 400,00 Banca della Campania BIC: IRPBIT3A CIN: H ABI: CAB: C/C: IBAN: IT08H The confirmation of your registration will be sent to the above mentioned fax or address I wish to join the congress bus service Yes ( ) No ( ) I will arrive by: train (.) on May _. flight (.) on May _ Date Signature

8 Hotel Booking Form Please type or use block capitals and send to the organizing secretariat by February 28, Title Name Date of birth _ Sex. Institution/Affiliation _ Institution address _ City _ State Postal Code Country Phone Fax _ _ Arrival date. Departure date. _ Hotel accommodation and cost per person/per night: Hotel Single room Double room Triple room Le Agavi ***** not available 160,00 not available California *** 150,00 75,00 60,00 Savoia*** 210,00 105,00 83,50 Vittoria** 120,00 60,00 53,50 La Bougainville** not available 40,00 35,00 La Florida** not available 43,50 39,00 Villa Maria Antonietta not available 45,00 40,00 Pensione V. Verde not available 45,00 41,00 These prices refer to the 2005 Meeting, they might have slight changes. P.S.: The rooms for young investigators at the La Bougainville Hotel and La Florida Residence cannot be shared with the accompanying persons. ( ) I wish to reserve a single room, if possible, at the following hotel ( ) I wish to reserve a double room, to share with (name and city) at the following hotel _ ( ) I have no preference for a single/double room, but I wish to reserve a room at the following hotel Date Signature