MADRID 11/06/09 EPIGENETICS AND NEW THERAPIES IN CANCER June 2009 Madrid, Spain ESO INSIDE TRACK CONFERENCE

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1 ESO INSIDE TRACK CONFERENCE MADRID 11/06/09 EPIGENETICS AND NEW THERAPIES IN CANCER June 2009 Madrid, Spain Chair: M. Esteller, ES Coordinators: S. Marsoni, IT - M.A. Piris, ES

2 APPLICATION AND ABSTRACT SUBMISSION Poster abstract deadline 15 MAY You may apply and submit your abstract to the Organising secretariat online at: Instructions for application and abstract submission Participants with new data relevant to the subject of the conference may submit one abstract to be considered for poster presentation. Only papers whose abstracts have been reviewed and approved by the conference coordinators will be presented. Abstracts should be written in English and the text should not exceed 2000 characters (or 450 words), title included. The title should appear in capital letters. For each author, type surname first, followed by first name and initials (presenting author in capital letters). List affiliations after the author's list. Indicate 3-5 keywords at the end of the text. The full address with telephone, fax number and of the corresponding author must be provided. The corresponding author will receive all the subsequent communication concerning this abstract. Please also indicate your approval for publication in case the abstracts are issued in a journal. It is the responsibility of the presenting author to ascertain whether all authors are aware of the content of the abstract before submission.

3 THURSDAY, 11 JUNE 9:00 Welcome Opening Session 9:15 Cancer epigenomes and epigenetic drugs M. Esteller, ES DNA METHYLATION INHIBITORS Preclinical M. Esteller, ES 9:45 Molecular modes of actions of DNA methyltransferase inhibitors F. Lyko, DE 10:15 Mechanism-based small molecules designed to restore the epigenetic silencing of tumour suppressor genes V.E. Marquez, US 10:45 Coffee break and poster viewing Clinical M.A. Piris, ES 11:15 Demethylating approaches in the biological and therapeutic continuum of myelodysplasia and AML of the elderly M. Lubbert, DE 11:45 Epigenetic targets in acute myeloid leukaemia C. Nervi, IT 12:15 Molecular mechanism(s) of the use of Epi-drugs against cancer L. Altucci, IT 12:45 Round table discussion 13:15 Lunch break HDAC INHIBITORS Preclinical V. Richon, US 14:30 Histone deacetylases and the development of epigenetic and non-epigenetic therapies S. Minucci, IT 15:00 Combination studies of DNMT and HDAC inhibitors in overcoming cytotoxic drug resistance R. Brown, UK 15:30 HDAC9 in cancer and epigenetic silencing of RAR signalling in AML A. Zelent, UK 16:00 Clinical applications of HDAC inhibitors N.B. La Thangue, UK 16:30 Coffee break and poster viewing Clinical R. Brown, UK 17:00 HDAC as a therapeutic target for cancer: Development of Vorinostat V. Richon, US 17:30 Epigenetic therapy of prostate cancer Speaker to be confirmed 18:00 B-cell lymphoma. Therapy driven by molecular signatures M.A. Piris, ES

4 FRIDAY, 12 JUNE OTHER EPIGENETIC MOLECULES AND TARGETS Preclinical A. Zelent, UK 9:00 A histone methyltransferase inhibitor A. Imhof, DE 9:30 Polycomb inhibitors Q. Yu, SG 10:00 Sirtuin, histone acetyltransferase and methyltransferase inhibitors A. Mai, IT 10:30 Compounds that target the non-coding RNA machinery Z. Xi, CN 11:00 Coffee break and poster viewing Clinical M.A. Piris, ES 11:30 Retinoids and arsenic trioxide in the treatment of APL F. Lo Coco, IT 12:00 Lessons to be learnt from the clinical development of HDAC inhibitors S. Marsoni, IT 12:30 Round table discussion Closing Session M. Esteller, ES 13:00 Heat-shock protein inhibitors in cancer therapy P. Workman, UK INVITED FACULTY L. Altucci, Seconda Università degli Studi di Napoli, IT R. Brown, Cancer Research UK/Beatson Laboratories, Glasgow, UK M. Esteller, IDIBELL, Barcelona, ES A. Imhof, University of Munich, Munich, DE N.B. La Thangue, University of Oxford, UK F. Lo Coco, Tor Vergara University, Rome, IT M. Lubbert, University of Freiburg Medical Center, Freiburg, DE F. Lyko, German Cancer Research Center, Heidelberg, DE A. Mai, University of Rome La Sapienza, Rome, IT V.E. Marquez, Center for Cancer Research, Frederick, US S. Marsoni, SENDO, Milan, IT S. Minucci, IFOM, Milan, IT C. Nervi, University of Rome La Sapienza, Rome, IT M.A. Piris, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, ES V. Richon, Merck Research Laboratories, Boston, US P. Workman, The Institute of Cancer Research, Sutton, UK Z. Xi, Nankai University, Tianjin, CN Q. Yu, Genome Institute of Singapore, SG A. Zelent, Leukaemia Research Fund Centre at the Institute of Cancer Research (LRFC at ICR), London, UK

5 HOTEL ACCOMMODATION FORM EPIGENETICS AND NEW THERAPIES IN CANCER, JUNE 2009, Madrid, Spain Please fill in this form in BLOCK CAPITALS and send to: Oscar Arraz/Victoria Aguayo, Viajes el Corte Inglés. C/Princesa 47, 4th Floor Madrid, Spain Tel: Fax: dccimad4@viajeseci.es Please reserve hotel accommodation by 10 May 2009 to ensure availability. After this date availability and rates will not be guaranteed and are to be confirmed on request. PARTICIPANT S DETAILS Surname Name Address Zip Code City Country Tel Fax Mobile LIST OF HOTELS Prices are expressed in Euro and include VAT and breakfast where not indicated separately. Please indicate preferred hotel Hotel Occidental Miguel Ángel ( ) Miguel Angel, 31 Double room or Double for single use breakfast included 180,83 AC Aitana ( ) Paseo de la Castellana, Double for single use breakfast included 161,57 Double occupancy breakfast included 175,48 Hotel ABBA Castilla Plaza ( ) Paseo de la Castellana Double for single use breakfast included 133,00 Double occupancy breakfast included 151,00 AC Los Vascos ( ) Los Vascos, 27 Double for single use breakfast included 135,89 Double occupancy breakfast included 144,45 AC Cuzco ( ) Paseo de la Castellana, Double for single use breakfast included 155,15 Double occupancy breakfast included 179,76 Date of arrival Date of departure Total: x number of nights Total due PAYMENTDETAILS CREDIT CARD Visa Holder's namecard Number / / / Exp. Date / CV2 code Tryp Centro Norte ( ) Mauricio Ravel, 10 Double for single use breakfast included 95,23 Double occupancy breakfast included 105,93 Signature BANK TRANSFER: All payments made by bank transfer must include the guest's name and the Ref. 'Epigenetics Conference'. El Corte Ingles Travel Agency must receive a copy of the bank transfer via fax not later than 24 hours after the confirmation has been sent to the client, otherwise the reservation will be cancelled. BANK TRANSFER DETAILS Bank transfers must be made with no cost to the beneficiary addressed to: BANCO BILBAO VIZCAYA ARGENTARIA IBAN: ES BIC/SWIFT: BBVAESMMXXX OBSERVATIONS Once the confirmation is made, the cancellation policy will be send by depending on the selected hotel. El Corte Inglés Travel Agency will charge the amount to the credit card previously established as the confirmation. All cancellations must be sent writing to El Corte Inglés Travel Agency.

6 GENERAL INFORMATION ORGANISING SECRETARIAT Ana Sofia Contreiras Cordeiro Scientific Events Office Centro Nacional de Investigaciones Oncológicas (CNIO) Melchor Fernández Almagro, 3 E Madrid - Spain Tel: Fax: meetings@cnio.es ESO SECRETARIAT Daniela Mengato European School of Oncology Via del Bollo Milan - Italy Tel: Fax: dmengato@eso.net REGISTRATION AND ABSTRACT SUBMISSION AVAILABLE AT: REGISTRATION Registration may be carried out online ( Registration fee is 200. Registration and payment must be processed by 15 May After this date registration will only be available on site at the rate of 300. The registration fee covers admission to the conference, a copy of the programme book, coffee and lunch throughout the conference as indicated in theprogramme. CONFIRMATION OF REGISTRATION Registration will only be confirmed upon receipt of the registration fee. Registration must be received by 15 May Please note that the number of participants is limited to 100. Early registration is strongly recommended in order to avoid disappointment. CANCELLATION OF REGISTRATION In case of cancellation without replacement, the fee less handling charges of 60 will be refunded, provided a written request is received by the Centro Nacional de Investigaciones Oncológicas (CNIO) before 15 May No refund can be made if notice of cancellation is received after this date. Refunds will be settled after the conference only. Replacements will be accepted only before 23 May OFFICIAL LANGUAGE The official language of the conference will be English. No simultaneous translation will be provided. CERTIFICATES All participants will be issued with a certificate of attendance at the close of the conference. BADGE The badge is the only official evidence of registration and should be worn at all times during the conference. Loss of badge means loss of registration. INSURANCE The organisers bear no responsibility for untoward events in connection with, before, during and after the conference. Participants are strongly advised to take out their own personal and travel insurance coverage. IMPORTANT DEADLINES 15/05/2009: poster abstracts deadline 15/05/2009: registration deadline 15/05/2009: cancellation deadline 23/05/2009: replacement deadline COURSE VENUE Centro Nacional de Investigaciones Oncológicas (CNIO) Melchor Fernández Almagro, 3 E Madrid - Spain