Coupling Engineering Sciences and Life Sciences: An overview of LAAS Activities with a special focus on Nano-Oncology Projects

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Marjorie Adams
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1 Christophe Vieu Toulouse University Chargé de Mission du LAAS Axe Interaction avec le vivant Coupling Engineering Sciences and Life Sciences: An overview of LAAS Activities with a special focus on Nano-Oncology Projects Laboratoire d Analyse et d Architecture des Systèmes

Sciences: An overview of LAAS Activities with a special focus on

2 Mobilis in Mobili* LAAS * J.Verne Vingt Mille lieues sous les mers, 1869

3 ALIVE Interactions with Life sciences and Environment - Oncology : A strategical orientation of LAAS-CNRS

4 Lab on chips, Micro-Fluidics, Integrated Biodetection

5 Dosing Biomarkers

6 In-Vivo communicating sensors Assisting Robots Implantable devices Medical Monitoring

7 ALIVE Working Groups - WG1: Molecular Engineering - WG2: Cellular Engineering - WG3: Biodetection - WG4: Bio-Inspiration - WG5: Modeling/Data processing - WG6: Applicative Fields

8 - Single molecule scale manipulations and measurements ( nanochannels,nanopores, single molecule assays) - Diagnostic, sequencing (genetics and epi-genetics investigations) Single stretched DNA molecules transfer-printed on a surface after directed assembly on a microstructured PDMS stamp Stretching of DNA molecules inside nanochannels for epigenetics investigations

stretched DNA molecules transfer-printed on a surface after directed assembly on a

9 - Single Cell manipulation and measurements (AFM, e.m) - Metrology and cell sorting (Fluidics, Imaging, physical discrimination) - Cell/device Interface (cell culture on nanoengineered surfaces, mechanosensing) - Cell/Cell interactions, (Tissue engineering, secretome analysis) Long range alignment of neurites through Micro/Nanaopatterning and control of stem cells differenciation Circular micro-coil, 20 turns, 5µm*5µm*5µm, I=150mA 0s 1s 2s Hydrodynamical and Magnetic Cell sorting devices 3s 4s 5s

nanoengineered surfaces, mechanosensing) - Cell/Cell interactions, (Tissue engineering, secretome analysis) Long range

10 «bona diagnosis bona curatio» Ultra high sensibility detection using Micro/nanosystems(FET, M(O)EMS, N(O)EMS, SERS, MEF) Micro/nano fluidics, concentrators Blood engineering In-Vivo communicating biodetection devices A Carbon NEMS detection device obtained by combination of capillary assembly and DEP of Double Walled Carbon Nanotubes (DWCNTs)

concentrators Blood engineering In-Vivo communicating biodetection devices A Carbon

11 - Hybrid (Bio/Artificial) devices (integration of Bionanomachines) - DNA Technologies for Nanofabrication (aptamers, DNA origami, DNA nanochannels) - Bio-assembled materials - Bio-Inspired Motility and cooperation 20 nm AFM Image of the MS-ring assembly of the bacterial flagellar nanomotor on an artifiicial suspended lipidic membrane Directed Assembly of NPs through DNA hybridization

Bio-Inspired Motility and cooperation 20 nm AFM Image of the MS-ring assembly of the bacterial

12 - Atomic Modelling of bio integrated technological processes and molecular interactions: molecular flexibility,ras protein,aptamers, DNA self-assembled nanostructures - Machine learning algorithms for biochip data processing - Modelling from robotics (ligand/receptor inetractions) - Brain Data processing

nanostructures - Machine learning algorithms for biochip data processing -

13 - A unique site in Europe where an Academic State of the art nanofabrication clean-room facility is coupled with a critical mass of Engineers and Researchers dedicated to life science applications. - An open access policy

with a critical mass of Engineers and Researchers

14 Micro Nano fabrication Platform 1500 m2 Clean room class to 100 nvestments : 3.5 M (CPER), 14.5 M (BTR).3 M (LAAS), 0.62 M (CA) RENATECH network

15 - Oncology (Toulouse Oncopole) - Neurosciences - Skin - Food and environmental security - e-medicine

16 LAAS-CRCT Joined Roadmap * in vivo Engineering: Embedded sensors and fishing tools * ex vivo Engineering: Biodetection and therapy follow-up * Tumoral Micro environment * Genome evolution under stress, therapy induced resistances Institut Universitaire du Cancer, Toulouse Oncopole CRCT: centre de Recherches en Cancérologie de Toulouse CUC: Clinique Universitaire du Cancer * Molecular simulations and BioInfo

stress, therapy induced resistances Institut Universitaire du Cancer, Toulouse Oncopole CRCT: centre

17 * ex vivo Engineering: 8th Cancer Scientific Forum 21 March 2013 Lyon - CLARA

18 * Molecular simulations and BioInfo 8th Cancer Scientific Forum 21 March 2013 Lyon - CLARA

19 9 th International NANOBIOEUROPE Conference June

20 Special Session on Nano-Oncology organized by CGSO&CLARA Single molecule technology Sensing based nanotechnology Imaging based nanotechnology Nano-objects & nanomaterial for life sciences Nano-enabled drug delivery Nanotechnology for cell characterisation & tissu engineering Nano-Oncology & Nanomedicine Nanotoxicity Scientific contributions presented at NBE2013 conference will be published in a special issue of BioNanoScience Journal

Imaging based nanotechnology Nano-objects & nanomaterial for life sciences Nano-enabled drug delivery Nanotechnology

21 Thank you for your kind attention

M.Sc. in Nano Technology with specialisation in Nano Biotechnology

M.Sc. in Nano Technology with specialisation in Nano Biotechnology Nanotechnology is all about designing, fabricating and controlling materials, components and machinery with dimensions on the nanoscale,