The EBMT Cellular Therapy and Immunobiology Symposium

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1 The EBMT Cellular Therapy and Immunobiology Symposium From Transplantation to Gene Therapy: Cellular therapy in evolution November 11 th -13 th, 2015 San Raffaele Scientific Institute

2 Chairman Dr. Chiara Bonini Experimental Secretary Prof. Christian Chabannon Paoli Calmettes Institute Cell Therapy Facility Marseille, France Dr. Fabio Ciceri Dr. Attilio Bondanza Dr. Luca Vago Sara Mastaglio Dr. Maria Ester Bernardo Pediatric Immunohematology Prof. Ettore Biagi Milano-Bicocca University San Gerardo Hospital Pediatric /Oncology Monza, Italy Prof. Claudio Bordignon Chairman & CEO MolMed Spa Dr. Giulia Casorati Experimental Immunology Dr. Nicoletta Cieri Experimental Unit Prof. Francesco Dazzi King s College Regenerative and Haematological Medicine London, UK

3 Prof. Gianpietro Dotti Baylor College of Medicine Center for Gene Therapy Houston, USA Prof. Hermann Einsele University Hospital Medizinische Klinik Wuerzburg, Germany Dr. Willem E. Fibbe Leiden University Medical Center Department of Immunohematology and Bloodtransfusion Leiden, The Netherlands Prof. Katharina Fleischhauer Essen University Hospital Institute for experimental cellular therapy Essen, Germany Dr. Maria Cristina Galli Istituto Superiore di Sanità Dept. of Cell Biology and Neurosciences Roma, Italy Dr. Eliane Gluckman Eurocord International Registry Hospital Saint Louis Paris, France Prof. Phil Greenberg University of Washington Fred Hutchinson Cancer Research Center Seattle, USA Dr. Michael Hudecek University Hospital Medizinische Klinik Wuerzburg, Germany Prof. Franco Locatelli Pediatric Hospital Bambino Gesù Onco- Roma, Italy Dr. Anna Mondino Lymphocyte Activation Prof. Luigi Naldini Tiget Prof. Richard O Reilly Memorial Sloan Kettering Cancer Center Department of Pediatrics New York, USA Prof. Karl Peggs University College Hospital Clinical Haematology London, UK Prof. Alessandro Rambaldi Papa Giovanni XXIII Hospital Unit Bergamo, Italy Dr. Annalisa Ruggeri Eurocord International Registry Hospital Saint Louis Paris, France

4 Dr. Carmen Ruiz de Elvira EBMT Central Registry Office London, UK Prof. Jaime Sanz Caballer University Hospital La Fe Valencia, Spain Prof. Antoine Toubert Paris Diderot University Institute Paris, France Dr. Marcel R.M. van den Brink Memorial Sloan Kettering Cancer Center Division of Hematologic Oncology New York, USA Prof. Andrea Velardi University of Perugia Perugia, Italy Wednesday, November 11 th 2015 The CTIWP Business meeting 14:00-17:30 Agenda TBD 18:00-19:30 Symposium Opening Lectures R. O Reilly, USA C. Bordignon, Italy

5 Thursday, November 12 th :00 Keynote Lecture M. van den Brink, USA Session I Cord Blood Transplantation: current challenges 9:40 J. Sanz, Spain 10:00 K. Peggs, UK 10:20 A. Ruggeri, France 10:40 E. Gluckman, France 11:00 Break 11:20 Keynote Lecture Cellular therapy to improve outcome of haplo-hsct A. Velardi, Italy Session II Cellular therapy to improve transplantation outcome 12:00 M.E. Bernardo, Italy 12:20 C. Chabannon, France 12:40 F. Dazzi, UK 13:00 Lunch Break 14:00 H. Einsele, Germany 14:20 F. Locatelli, Italy 14:40 G. Casorati, Italy

6 15:00 Keynote Lecture W. Fibbe, The Netherlands Session III The use of genetically redirected T cells: Improving SCT or replacing SCT? 15:40 N. Cieri, Italy 16:00 A. Bondanza, Italy 16:20 M. Hudecheck, Germany 16:40 G. Dotti, USA 17:00 Keynote Lecture P. Greenberg, USA 17:40 Round table Cellular Therapy: Improving the outcome of SCT or replacing SCT? Friday, November 13 th :00 Keynote Lecture L. Naldini, Italy Session IV Regulation, harmonization and sustainability of cellular therapy: what can we learn from SCT? 10:00 A. Rambaldi, Italy 10:20 C. Ruiz de Elvira, UK 10:40 Coffee break

7 11:00 E. Biagi, Italy 11:20 M.C. Galli, Italy 11:40 A. Mondino, Italy 12:00 Round Table From HSCT to cell therapy and gene therapy: regulatory hurdles and innovative business models 13:30 Lunch Break Session V Cellular Therapy and allo-sct: guidelines for patients follow-up 14:00 A. Toubert, France 14:20 K. Fleischhauer, Germany 14:40 L. Vago, Italy 15:30 Closing remarks

8 USEFUL INFORMATION CONFERENCE VENUE SAN RAFFAELE CONGRESS CENTRE Via Olgettina Milano - Italy ORGANIZING SECRETARIAT Achelois Srl Via Larga Milano Phone: elena.delboca@achelois.eu REGISTRATIONS Attendance to the Symposium is free of charge. Please send the registration form to the Organising Secretariat by October 26 th, ACCOMMODATION Please be informed that the period in Milano is very overcrowded due to some trade shows. We suggest to book your hotel room well in advance, to grant both availability and lower prices. To help you with your accommodation, please note that the following hotels are the nearest to the congress venue (no allotments of rooms have been reserved): RAFAEL HOTEL***S Via Olgettina Milano - Italy Phone: The hotel is located in the San Raffaele Complex, within a walking distance of the Congress venue.

9 NH MILANO2 HOTEL**** Via F.lli Cervi Milano2 - Italy Phone: The hotel is 10 minutes walking distance from the Congress venue. STUDIOS HOTEL**** V.le Europa Cologno Monzese (Mi) - Italy Phone: The hotel is 5 km from the Congress venue (not walking distance). Usually a shuttle service is provided by the hotel to get to the San Raffaele Congress Center. HOW TO GET TO THE CONFERENCE VENUE AIRPORTS Milano Malpensa (MXP) Milano Malpensa is located 48 km (30 miles) northwest of Milano and is the main hub for Northern Italy, handling transcontinental and international flights. How to reach the San Raffaele Congress Centre by public transport: - a shuttle bus service links Malpensa Airport to the Cascina Gobba Subway Station. The trip takes about 1 hour, depending on the traffic. For more information, please visit - Section Time Table - Itinerary Malpensa T1-T2/Linate. At the Cascina Gobba Subway Station, you will find bus nr. 925, or the People Mover Shuttle, which takes you directly to the San Raffaele Congress Centre. Milano Linate (LIN) Milano Linate is located 7 km (4 miles) east of the City Centre and it is easily connected with the city. How to reach the San Raffaele Congress Centre by public transport: - a shuttle bus service links Linate Airport to the Cascina Gobba Subway Station. The trip takes about 10 minutes, depending on the traffic. For more information, please visit - Section Time Table Itinerary Linate/Malpensa T1-T2. At the Cascina Gobba Subway Station, you will find bus nr. 925, or the People Mover Shuttle, which takes you directly to the San Raffaele Congress Centre.

10 Orio al Serio International Airport (BG) Orio al Serio is located 45 km (28 miles) northeast of Milano and handles domestic and international flights, most of them operated by low-cost carriers. How to reach the San Raffaele Congress Centre by public transport: - a shuttle bus service links Orio al Serio Airport to Milano s Railway Central Station. The trip takes about 1 hour, depending on the traffic. For more information, please visit the following web site: The green line subway links the Railway s Central Station to the Cascina Gobba Subway Station, where you will find bus nr. 925, or the People Mover Shuttle, which takes you directly to the San Raffaele Congress Centre. RAILWAYS Milano s main train station is the Stazione Centrale (Central Station) which has high-speed train links to other major Italian and European cities. Other important Railway Stations are: Cadorna, Lambrate, Porta Garibaldi. How to reach the San Raffaele Congress Centre by public transport: - the green line subway links all the above mentioned Railway Stations to the Cascina Gobba Subway Station. At Cascina Gobba you will find bus nr. 925, or the People Mover Shuttle, which takes you directly to the San Raffaele Congress Centre. MOTORWAYS Milano is linked to other Europen countries by toll motorways. The San Raffaele Congress Centre can be reached by all motorways following the direction Tangenziale Est until the Cascina Gobba exit CITY PUBLIC TRANSPORT The nearest Subway Station is Cascina Gobba Green line where you will find bus nr. 925, or the People Mover Shuttle, which takes you directly to the San Raffaele Congress Centre.

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