J-KEM. Scientific, Inc. Temperature Control. Reaction Automation. Custom Robotics. Instruments for Science from Scientists

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1 J-KEM Scientific, Inc. Instruments for Science from Scientists Temperature Control Reaction Automation Custom Robotics J-KEM Scientific 2009

2 Product Highlights Digital Temperature Controllers Precision Temperature Controllers for Research Regulate volumes from 100 µl to 22 L High Power & High Safety Controllers Reactors up to 100 L Economy Temperature Controllers Digital Vacuum Regulator Digital Control of Vacuum Pressure from 760 to 0.1 torr Regulate Vacuum to 0.1 torr with DVR-1000 NEW in 2009 USB standard on all 200-Series temperature and vacuum controllers Free Windows control & data logging software 0.1 o C Regulation < 1 o C Over-shoot Parallel Synthesis & Lab Automation Equipment Syringe Pumps Delivery rates from 1 µl/min to 375 ml/min Single & Multiposition pumps PC & stand alone operation Deliver any volume from any syringe Parallel Reaction Systems Solution phase & solid phase reaction systems PC control of: - Reagent delivery - Temperature - Pressure Custom designs Reaction Block Systems Heat, cool, & reflux KEM-Lab Personal Reaction Blocks Multiple vial sizes Custom designs Multiple Temperature Zones Custom Robotic Workstations Robotic Solutions Custom hardware and software Weighing Dissolution Reformatting Solid & Solution phase Synthesis Cherry picking Solid phase extraction User Programmable All robots include the original source code NEW - Endeavour Robots priced from $6000 Capping/Uncapping Station

3 Adapters, Thermocouple 39 Automation Equipment Robotics 2-9 Fluid Delivery Reactors 14-15, 25 Chiller, Circulating 24 Evaporators KEM-Vap 27 Microtiter Plate 23, 27 Reaction Block 18 Custom 27 Fraction Collector 9 Gas Heater 29 Glass Microtiter Plate 23 Heating Mantles 40 Hand-Held Meters 29 KEM-Lab Reactors 23 KEM-Prep Reactor 17 KEM-Vap Evaporator 27 Monitors Temperature 28 Vacuum 30 Water Flow 28 Nitrogen Gas Heater 29 Oil baths, Instatherm 40 Over-Head Stirrer 25 Parallel Synthesis Reactors Solution Phase Solid Phase 26 Temperature Control Index Personal Reaction Station 16 Pressure Regulator, Digital 31 Reaction Blocks Single Temperature Zone 18 Multi-Temperature Zone 22 Custom Shaker 19 Reaction Controller 14 Robotics Instruments 2-7 Accessories 8-9 Do-It-Yourself 7 Safety Equipment Lab Safety Controller 28 Water Flow Monitor 28 Digital Temperature Monitor 28 Temperature Controllers 35 Shakers Benchtop, Reaction Block 19 KEM-Lab 23 Robotic 8 Solid Phase Extraction Station 8 Solid Phase Synthesis Reactor 26 Solvent Evaporator 27 Stirrer, Miniature Overhead 25 Syringe Pump Single and Multi-Channel Custom Do-It-Yourself 11 Temperature Controllers Research Controllers Multi-Channel 34 Safety 35 High Power 35 Oil Bath Controller 36 Economy 36 Custom 25 Monitors 28 Safety Limit Controller 28 Power Controller 29 Thermocouples & Accessories Temperature Monitor 28 Thermocouples Single Element Dual Element 35 Glass Coated 38 Teflon Coated Hypodermic Needle Probe 39 Thin Wire 39 Cords and Accessories 38 Trinity Power Controller 29 USB Network Extenders 37 Vacuum Regulator, Digital 30 Monitors 30 Precision 31 Variac, Solid State 29 Water Flow Monitor 28 Who We Are 41 Heating Profile of J-KEM s 200-Series Temperature Controllers Model 210 controller shown with power control computer J-KEM s patented power control computer makes this the only controller that can heat volumes under 100 µl with the safety of 0.1 o C regulation. Actual heating data is shown at right. J-KEM Scientific, Inc Olive Blvd. Saint Louis, MO USA Ordering Information J-KEM Scientific, Inc. Phone: (314) (800) FAX: (314) [email protected] On-line Catalog: The J-KEM Guarantee All J-KEM products are guaranteed to be the highest quality and most accurate instruments available. Any J-KEM product not meeting your expectations can be returned within 30 days for a full refund. Robert C. Elliott / President

4 Custom Laboratory Robotics Eclipse Workstation With four robot styles and multiple software options, J-KEM is uniquely positioned to offer custom robotic solutions for virtually any lab automation need. J-KEM s technology makes lab automation as Simple as 1, 2, 3. Key Features: Fast Positional accuracy Affordable Multiple Z-probes Phoenix Workstation 1 Four Robotic Platforms to Choose From With four different robotic platforms, J-KEM can select the one that most efficiently automates your unique application. Each platform has its own set of advantages including speed, positional accuracy, power, and price that make it the preferred system for different applications. Key Features: Large deck size Multiple Z-probes Generates > 100 lb. of force in the Z- direction. Voyager Workstation 2 Custom Solutions J-KEM offers complete hardware and software solutions for almost any lab automation task. Every workstation is customized with the features and software needed to run your specific application. Workstations for: Weighing Dissolution Synthesis Sorting Crystallization Cherry picking SPE SPS Spectroscopy Key Features: Fast Optimized for microvial weighing and cherry picking applications Endeavour Workstation Key Features: Fast Positional accuracy Most affordable workstation available 3 Do-It-Yourself Robotics New in 2009 J-KEM offers each of its robotic systems with custom programming, professional installation, and user training. For most researchers, this is the service they both need and expect. For those research teams who prefer to do it themselves, J-KEM now offers each of its robotic systems as a fully configured and tested workstation, but with no pre-installed software. With complete systems starting under $6,000, this is a highly affordable way to introduce robotics to your workflow. Software options are available to support your custom development. Page 2 J-KEM Scientific Toll-free: (800) Fax: (314) [email protected]

5 Eclipse Robotic Workstations The Eclipse workstation uses modular X- and Y-axis rails combined with a wide selection of automated tools such as grippers, multi-position needles, and custom probes. The open design of the Eclipse provides easy access to the entire workstation deck. Value: From $20,000 Affordability: The affordable price of the Eclipse (starting under $20,000) creates new opportunities for lab automation. For example, a weighing station with bar code scanner and 0.01 mg resolution balance costs about $28,000. Features: Speed: 400 mm/sec Positional Accuracy: ±0.02mm Z-Axis Force: 10 pounds Examples of Eclipse Workstations Test Tube Weighing Station Bar code scanner Excel output Analytical balance Plate Washer with Heated Reaction Station See the Eclipse in action at: Solid Phase Extraction Station Multi-step synthesis program run in micro titer plate cells Plate gripper Temperature controlled reactor 24 Columns developed in parallel Controls flow rate in all columns Solvent level in each column is optically monitored to stop solvent flow when the solvent front reaches the top of the packing. Derivatization Station Spectroscopy Robot Automated spectroscopic analysis of 200 samples Reagent addition to septum vials Heated reactor with mixing Reaction mixture sampled at user set times to GC vials J-KEM Scientific Toll-free: (800) Fax: (314) [email protected] Page 3

6 Advantages of J-KEM Robotics Custom Design While others start from an existing design, then try to make your application fit their instrument, every J-KEM workstation is designed from scratch to implement your automation task efficiently and with an eye towards future expandability. J-KEM s experience in lab automation, including temperature control, reactor design, fluid delivery, solid and solution phase synthesis is invaluable when optimizing the design of custom robotics. Polymer Compounding Robot Modules: 4-Temperaure zone reaction block, balance, bar code reader, heated & cooled reagent block, cooled 4-position sonicator, precision syringe pump with 16 reagent ports, 6-zone temperature controller, and needle wash station. You Own the Solution J-KEM believes that you should not only own the instrument, but you should own the technology that created the instrument. That s why we are the only company that releases the original source code with every robot. This gives you the power to change every aspect of the robot s operation as your automation needs change. Custom Software Custom software is written for every workstation to provide an intuitive user interface. The procedure s setup, the way data is read into and out of the program, and the exact sequence of program steps are all customized to make the operation of your robot both efficient and user friendly. Personal Service J-KEM is committed to personal service, offering any support that s needed to assure the successful integration and productivity of our automation solutions. With one phone call, you can talk to the engineer who designed your robot, the engineer who installed it, and the software engineer who wrote the program. Value J-KEM s custom robotics are often half the price of other companies one-size-fits-all alternative. While many of the modules on a workstation are standard J-KEM products, we also use the best available instruments like balances, bar code readers, and pumps to assemble the final workstation in the most affordable and efficient manner. It s not really enough to own the code if it s not easy to use. Written in VB.Net, the robotic software contains intuitive, high level functions that make understanding or modifying your code easy. Consider the example to the right that weighs every vial in a 96 vial rack. For Vial = 1 to 96 Rack.MoveToCell(XY, Vial) Gripper.PickUpVial() Balance.Tare() Balance.MoveToCell(XY, 1) MyWeight = Balance.Weight() PutVialBack(Vial) Next Why is it important to own the original source code? Without the source code, you re stuck with the robot you have rather than the robot you need as your automation needs change. For example, suppose the robot s original task was weighing and dissolving samples to specific concentrations, but now you need it to add reagents to 4 ml septum vials in a temperature controlled reactor with mixing. In most cases you d need to purchase a new robot. Even for small changes, if you don t own the original source code, then you re 100% dependent on the company who does. J-KEM offers ongoing software support for all of our customers. But still, to own the tools that place you in control of your own workstation is invaluable. Page 4 J-KEM Scientific Toll-free: (800) Fax: (314) [email protected]

7 Phoenix Robotic Workstations Phoenix workstations have three distinctive characteristics: 1. Large deck size that allows access to multiple racks and modules such as shakers, balances, and filter stations. 2. Multiple Z-probe tools. This robot has simultaneous access to three 2.5 ml disposable tip probes, three 200 µl disposable tip probes, a septum penetrating needle, a vial gripper, three stainless steel cannula, and a pressure plate to filter samples using positive pressure. Sample Dilution and Filtration Station 3. The Z-axis can develop over 100 pounds or force, enough to penetrate any septum or seal any reactor. Enzyme Specific Activity Workstation Examples of Phoenix Workstations Cherry Picking and Sample Reformatting Workstation Robot Modules Deck fits five Gilson racks of any style Disposable pipette tip probe Syringe pump with 8-port selectable valve Workstation Procedure In this application, samples arrive in a variety of formats, including 4 ml, 8 ml, and 20 ml vials, three different size test tubes, 24, 48, and 96 well titer plates. This workstation reformats samples from the various tubes to a single 96 well plate. From the master plate, a cherry picked plate is made based on the input from an Excel table. Workstation Procedure Samples are transferred, by weight, to 400 ml beakers where they are diluted 1200-fold. After mixing, diluted samples are dispensed to sample vials for analysis. Robot Modules Analytical balance 60-position high power magnetic stirrer Syringe pump with 8-port selectable valve Gripper for vial transport Cannula for large volume dispenses (> 100 ml) and analytical needle for microliter dispenses Sample Dissolution and Daughter Plate Preparation Robot Modules Syringe pump with 8-port selectable valve Analytical balance Bar code station Gripper for vial transport Septum penetrating needle Workstation Procedure Dissolves solid samples to a standard concentration, then adds additional liquid reagents. After mixing, transfers aliquots to HPLC vials with septum caps and to a titer plate cell. The identity of all vials are tracked by bar code, and the volume of reagents dispensed is verified by weight. J-KEM Scientific Toll-free: (800) Fax: (314) [email protected] Page 5

8 Voyager Robotic Workstations The Voyager workstation is optimized for weighing and sorting glass or plastic vials in 96 position tube racks. The Voyager integrates a Mettler balance with 10 µg resolution, an Opticon 2D bar code scanner, and high speed X, Y, & Z drives. Combining world-class hardware with intuitive software makes the Voyager the finest workstation for tube handling available. See the Voyager in action at: Intuitive Software Voyager s software includes applications for weighing, scanning, sorting, and cherry picking tubes. Support for data input and output from a variety of file formats, including Excel,.CVS, and.txt files is standard. Custom input/output file formats to access corporate data bases or to interface with other laboratory instruments is available. The Z-arm automatically adjusts to different tube heights and even supports different tube sizes in the same run. Various liquid dispensing options are available for microliter to milliliter aspirate and dispense operations. Features: Weighs up to 220 vials per hour g (10 µg) balance 2D bar code scanner decodes 2D and all 1D bar code symbologies Gripper customized to individual vials Reads and writes to any data base Liquid dispensing/transfer options Applications: Tube identification and weighing Tube sorting and re-arraying Cherry picking Voyager-12 Workstation The Voyager-12 has positions for 12 tube racks and 2 additional receiving racks for re-arraying or cherry picking. Includes a Mettler balance with 10 µg resolution and 2D bar code scanner. Specifications: Dimensions: 30 x 26 x 20 (DxWxH) Speed, X & Y-axis: 120mm/sec Positional accuracy: 0.02mm Tube Heights: 0.5 to 2.5 inches Communications: Requires 1 USB port Power: 120 watts Voyager-24 Workstation The Voyager-24 has positions for 24 tube racks plus 2 additional receiving racks for re-arraying or cherry picking. Includes a Mettler balance with 10 µg resolution and 2D bar code scanner. Specifications: Dimensions: 30 x 38 x 20 (DxWxH) Speed, X & Y-axis: 120mm/sec Positional accuracy: 0.02mm Tube Heights: 0.5 to 2.5 inches Communications: Requires 1 USB port Power: 120 watts The Voyager workstation can be equipped with custom grippers to transport a variety of tube styles, including centrifuge tubes. $19,950 $21,600 Optional Features Microtube above balance pod Stainless steel or PTFE cannula for the addition of liquid reagents Spectroscopic probes Mixing Heated reaction stations Custom user modules Page 6 J-KEM Scientific Toll-free: (800) Fax: (314) [email protected]

9 Endeavour Robotic Workstations Starting under $6000 The Endeavour is J-KEM s most compact and affordable system, an ideal choice when either bench space or budgets are limited. The Endeavour is also a great starting point for researchers who want to develop their own automation instruments. In one compact enclosure, the Endeavour includes all the needed electronics, drivers, and power supplies. Combined with J-KEM s software, the Endeavour can be programmed to run complex motion control programs, even 3-axis arc interpolations, in a matter of hours. The Endeavour is servo motor controlled to provide rapid and precise motions with positional accuracies of 0.02mm. Software Support Two software packages are available for the Endeavour robot. Endeavour.dll exposes high level functions, like those shown in the example below, that handle all of the low-level tasks associated with serial communications and motor control. Endeavour.dll exposes functions for every motion parameter including acceleration, positioning, homing an axis, and I/O support. Endeavour.dll is included at no charge with all orders. J-KEM also offers its AutoKem software written in Microsoft s Visual Studio 2008.Net in the Visual Basic language. AutoKem provides the user with a feature rich application having classes for racks, balances, syringe pumps, bar code readers, and many other instruments so they can be added to an application with only a few lines of code. The original source code for AutoKem is provided to further support Examples of Robot Commands from Endeavour.dll custom programming. Command Description HOME(X) Home the X axis. MOVE(Y,127.40) Move on the Y axis to position mm. J-KEM manufactures custom modules for the Z plate of the Endeavour robot. Grippers Needles Syringes Disposable tips Two Axis Endeavour MOVE(X,100.0, Y,235.0, Z,25.5) Perform a simultaneous 3-axis move to the specified coordinates. OUTPUT(12,ON) Turn user I/O output 12 on. INPUT(7) Returns 0 if the input is low, 1 if high. Endeavour Catalog # Price Two Axis Endeavour Robot Provides 200mm of addressable space on both the EN22020 $5, X- and Y-axes. Y-axis supports 9 pounds. Dim: 320 x 405 x 320 mm (W x D x H). Two Axis Endeavour Robot Provides 400mm of addressable space on both the EN , X- and Y-axes. Y-axis supports 9 pounds. Dim: 520 x 605 x 320 mm (W x D x H). Three Axis Endeavour Robot Provides 200mm of addressable space on both the EN , X- and Y-axes and 100mm of stroke length in the Z-dimension. Z axis supports up to 4.5 pound loads. Dimensions: 330 x 405 x 420 mm (W x D x H). Three Axis Endeavour Robot Provides 400mm of addressable space on both the EN , X- and Y-axes and 100mm of stroke length in the Z-dimension. Z axis supports up to 4.5 pound loads. Dimensions: 530 x 605 x 420 mm (W x D x H). Endeavour Software Catalog # Price Endeavour.dll Software support for the Endeavour robot. N. C. AutoKem Software Source code in VB.Net 2008 for the Endeavour robot. AutoKem $ Call J-KEM for complete function list. Specifications for all Endeavor Robots Call for drill guides and additional specifications. Speed: mm/sec Positional Accuracy: 0.02 mm I/O: 16 general purpose optically isolated logic level inputs and 16 open collector optically isolated outputs (100 ma). +24 V & Gnd. Communications: USB and RS232 Power: Vac input; 200 watts J-KEM Scientific Toll-free: (800) Fax: (314) [email protected] Page 7

10 Robotic Workstation Accessories Robotic Shaker Specially designed for robotic applications, this low profile shaker is less than 5 tall. The key feature of the RS2000 is its ability to home to an absolute X- and Y-coordinate when stopped with accuracies better than 0.1mm in both the X and Y dimensions. Homing to a known coordinate allows the robot to reliably access modules attached to the shaker s mounting plate. Triple eccentric drives provide vigorous mixing of loads up to 60 pounds. Catalog # RS2000 Specifications: Price $5, Dimensions: Rotational speeds: Maximum load: Shaking motion: Orbital radius: Communications: x 20 x 4.75 (WxDxH) rpm 60 pounds Orbital or linear 0.4 Can be customized USB, RS232, RS485, binary, manual Solid Phase Extraction Station The KEE-100 automates 24-positions of solid phase extraction. The KEE-100 works by regulating the solvent flow rate and optically monitoring the position of the solvent front above the top of the column packing in each column individually. When the solvent front reaches the top of the packing, a Teflon valve closes preventing the packing from going dry. Individual control of solvent flow rate and position ensure reproducible results. SPE columns can be developed either by vacuum or positive pressure. Optical sensors Teflon valve 24-microcontrollers Inside the KEE-100 Specifications: 24 Positions Column diameter: 1/8 to 1 Solvent compatibility: Organic & aqueous Flow rates: 0.05 to 4mL/min Includes: SPE station and computer controller Multi-Position Syringe Pumps KEE-100 Price: $25,200 Custom syringe pumps with 4 to 48 glass and Teflon syringes. Syringe pump controller (included) regulates the rate and volume of dispense and fill cycles and automatically refills syringes when needed. Dispenses from one or all syringes in parallel. Syringe sizes from 10 µl to 50 ml. See page 10 for additional syringe pump options Prices varies depending on syringe size and features 8-Position pump: From $8, Position pump: From 10, Position pump: From 14, Position pump: From 19,440 J-KEM s engineers design whatever is needed to efficiently automate your laboratory task Custom Modules Custom Fluid Dispensing Options Heated and Cooled Reactors for incubations and crystallizations 4-Position Sonicater Page 8 Florescence Probe on Z-arm Temp. Controlled Filter Station J-KEM Scientific Toll-free: (800) Fax: (314) [email protected]

11 Capping & Uncapping Station J-KEM s capping module automates the removal and replacement of caps from sample vials. The capper removes, then replaces one cap at a time eliminating the possibility of cross contamination. The top and bottom grippers automatically adjust to caps with diameters from 8 mm to 26 mm (2 ml to 20 ml vials) with no tooling changes, and can be adjusted for cap diameters up to 35 mm and vial heights of 125 mm. Thread pitch, the number of turns needed to remove a cap, and recapping torque are all software programmable. Available with RS232 or USB. Capping Station Features: Automatically adjusts for - Cap diameter - Vial height - Thread pitch Adjustable capping force No limit on the number of turns Fraction Collectors Price $12,750 The capping station mounted to a J-KEM weighing robot J-KEM manufactures custom fraction collectors for any research application, from a simple 2 axis to a sophisticated 3 axis instrument running a custom, user specified, program. Features: External inputs & outputs for tube advance Collect to a single or multiple racks Fractions taken as a function of: - Time - Input voltage - User specified parameter Custom inputs/outputs to interface with other instruments Custom fraction collector holds 12 microtiter plates The Endeavour s affordable price makes it a perfect intelligent fraction collector. The Endeavour can be programmed to collect fractions based on any input parameter and according to any pattern. For example: 1) Place the fi rst 40% and the last 40% of any peak in one common test tube, but put the middle 20% in a GC vial for analysis. 2) Collect each peak to a single tube. After the fractionation process is done, go back and transfer 1mL of each collected peak to a GC vial for analysis. This is great stuff, but what I really need is... J-KEM welcomes the opportunity to work with you on any automation project. Put our experience in robotics, reactor design, fluidics, and custom programming to work for you. J-KEM Scientific Toll-free: (800) Fax: (314) [email protected] Page 9

12 Programmable Syringe Pumps Single Position Syringe Pump Model SYR-1200 Flow rates from 0.75 µl/min to 375 ml/min Syringe automatically refills to deliver any volume from any syringe PC control and data logging with KEM-Commander software Dual Position Syringe Pump The SYR-1200 syringe pump automates the addition of reagents at user entered rates. A programmable distribution valve allows the system to dispense to and withdraw from up to 8 reagent bottles or reactors in any sequence. In addition to the standard programs pre-loaded in the controller (see below), J-KEM offers custom programming at no additional charge to automate virtually any fluid delivery task. Additionally, KEM-Commander PC software allows the user to build sophisticated delivery programs with an intuitive drag-n-drop interface. Ordering information for the SYR-1200 and accessories is on page 13. Standard Syringe Pump Programs Standard programs are permanent and pre-loaded in the syringe pump controller Program 1. Timed Addition Sequentially adds up to 16 reagents to a single or multiple reactors at user specified rates. The syringe automatically primes and refills with the active reagent as needed. Example (pump fitted with a 5 ml syringe): 1) Add 12mL of reagent A at a rate of 3 ml/min 2) Add 2.5mL of reagent B at a rate of ml/min 3) Delay 1 hour 4) Add 10mL of reagent C at a rate of 60 ml/min Program 2. Program Loader Use KEM-Commander PC software (included) to construct a custom syringe pump program in a drag-ndrop visual environment. Program Loader then uploads that program to nonvolatile memory in the syringe pump controller. Once stored in the controller, the program can be run at any time with no PC needed. Construct programs for parallel reactions, filling titer plates, washing, or any custom application. Program 3. PC Control Places all functions of the syringe pump under PC control. Useful for robotic applications or when part of a larger automated reaction system. Program 4. Custom At no additional charge, the user can specify a custom syringe pump program. This program is written by J-KEM and stored as one of the permanent programs. Program 5. Update Manager Allows new or updated programs, available from J-KEM (via or web site), to be uploaded into permanent memory. Program 6. Concurrent Addition (SYR-2200 only) Adds two reagents in parallel to a common reaction at two independent rates. Program controlled distribution valve fills and dispenses from up to 8 ports Glass and Teflon syringe Delivery rates from 0.75 µl/min to 375mL/min Up to 16 pumps can be combined into a single system KEM-Commander Software KEM-Commander is standard with every pump and allows the user to construct sophisticated syringe pump programs in an intuitive drag-ndrop environment. Programs can then be run/saved/recalled from the PC or uploaded to the pump. Program 7. Serial Dilution (SYR-2200 only) Repeatedly dispenses two reagents in a user specified ratio. For a comparison of the features of the SYR-1200 and the SYR-1400, see page 12. Page 10 J-KEM Scientific Toll-free: (800) Fax: (314) [email protected]

13 NEW Model SYR-1400 Syringe Pump The SYR-1400 is the most versatile syringe pump available. The SYR-1400 is operated from a PC running J-KEM s KEM-Pump software. KEM-Pump implements all the programs of the SYR-1200 plus additional programs for serial and multi-reactor reagent additions. Unlike any other syringe pump, KEM-Pump is an open source code application that allows researchers with programming experience to create their own applications without limitations (see blue insert below). Demo software at: Ordering information for the SYR-1400 and accessories is on page 13. The SYR-1400 system includes both the syringe pump and KEM-Pump software. KEM-Pump is open source, graphical software that includes both pre-written applications and the original source code, in VB.Net, to allow users to create their own custom applications. KEM-Pump is a bold advance in laboratory automation that provides the user unprecedented control over how the syringe pump operates. KEM-Pump handles the low level tasks, like serial communications, then exposes high level functions for virtually any syringe pump action, greatly simplifying the effort needed to write new applications. For example, the code block below fully implements dispensing any volume of reagent at a user specified rate; syringe refills are handled automatically. The list of functions and a complete programmer s manual is available at jkem.com. Public Sub StartTimedAddition(ByVal Exp as RunData, Byval PumpAddress as Int32) Start a timed addition experiment. Data is contained in the RunData structure Me.mnuStart.Enabled = False Me.mnuAbort.Enabled = True Pump.TimedAddition(Exp, PumpAddress, False) Start the experiment and return immediately Do Pump.DrawPump(CurrentVolume) Draw a graphical representation of the pump Me.txbAddedVolume.Text = Format(CurrentVolume, ) While Pump.IsRunning Me.mnuStart.Enabled = True Me.mnuAbort.Enabled = False End Sub Pre-written applications include: Timed Addition - Multi-Step Timed Addition - Multi-Reactor Addition - Program Builder - Custom Syringe Pump Applications Adds a single reagent (any volume) to a single reactor at a user specified rate Adds up to 16 different reagents, independent volumes and rates to a single reactor Adds a single reagent to 1-7 different reactors at independent rates and volumes A drag-n-drop application, for non-programmers, to build sophisticated pump programs Sixteen pump system provides continuous delivery of 8 reagents in any volume and at independent rates. Custom Windows software, operator and administrator levels of program control, and data storage. Four Position Temperature and ph Controller Pump with 4 independent temperature controllers. Maintains the temperature and ph in 4 independent reactions. Custom software with data logging, program storage and recall. 16-Position with half-sized pumps J-KEM Scientific Toll-free: (800) Fax: (314) [email protected] Page 11

14 Comparing the Features of the SYR-1200 and the SYR-1400 Syringe Pump Systems J-KEM s two syringe pump systems, the SYR-1200 (page 10) and the SYR-1400 (page 11) share many of the same features, but differ in several important ways that may make one system better suited for your application. The key differences between the SYR-1200 and the SYR-1400 are 1) the SYR-1200 has its own syringe pump controller allowing it to be used as a stand-alone instrument while the SYR-1400 requires a PC for operation, and 2) the SYR-1400 is substantially more versatile, taking advantage of the power of a PC. The SYR-1200 Both the SYR-1200 and the SYR-1400 use the same pump module. This means that both systems provide identical performance in regards to flow rate range and accuracy. It also means that both system use the same syringes, distribution valves and other accessories. The SYR-1400 Controller The SYR-1200 is operated from its own computer controller which means that a PC is not required for operation. The controller stores and recalls the various programs and has a keypad for user input and a screen to display the experiment s progress. Standard Programs The syringe pump controller has the most common and useful pump applications loaded into permanent memory (see page 10). Custom Programs J-KEM offers to write one custom program and load it into permanent memory at no additional charge. Creating New Programs The SYR-1200 comes with a free PC application called KEM-Commander. With KEM-Commander, sophisticated scriptstyle programs can be built in a drag-n-drop environment that can then be run from the PC. KEM-Commander programs can be thousands of commands long. Examples of program script commands are shown below. Port(1) Go to valve port 1 Fill() Fill the syringe Rate(12.0) Set rate to 12 ml/min Dispense(100.0) Dispense 100 µl DelayMS(500) Delay 500 ms Withdraw(2500.0) Withdraw 2.5 ml Home() Empty the syringe Syringe Sizes: 10 µl to 50 ml Glass & Teflon wetted parts Dispense resolution is 1/48,000 of the syringe size in use Easily interchangeable Valve With 3 to 8 program selectable ports All wetted Teflon parts Optional I/O Use external inputs to start/stop flow, change flow rate, or port position. Control external valves or other devices under program control. Motor Stall detector Controller The SYR-1400 is operated from your PC. Programs are stored and recalled, and the experiment s progress is displayed on the PC. Standard Programs The SYR-1400 comes with KEM-Pump graphical control software that runs the syringe pump module. KEM-Pump implements all of the standard programs of the SYR-1200 plus several others. Custom Programs J-KEM offers to write one custom program and add it to your copy of KEM-Pump at no additional charge. Creating New Programs With the SYR-1400, new programs are created by adding your code to J-KEM s open source syringe pump application, KEM-Pump, written in Microsoft s VB.Net. For researchers with programming experience, the versatility of the syringe pump system is limited only by your imagination. KEM-Pump contains high level functions that provide intuitive access to every syringe pump feature. Using these functions, virtually any syringe pump program can be created in a matter of hours. For researchers without programming experience, one of the screens in KEM-Pump builds new syringe pump programs by dragging commands to a script-style command list. KEM-Pump also has an intuitive graphical interface that displays the status of a running experiment in real-time. Page 12 J-KEM Scientific Toll-free: (800) Fax: (314) [email protected]

15 Syringe Pump Ordering Information Programmable Syringe Pump, SYR-1200, with Computer Controller Description Cat # Price Single position syringe pump with stand-alone computer controller (shown on p.10). 120 Vac version SYR-1200 $ System requires the selection of one syringe and valve (below) for operation. 230Vac, CE approved SYR Dual position syringe pump with stand-alone computer controller (shown on p. 10). 120 Vac version SYR System requires the selection of two syringes and valves (below), one for each pump. 230Vac, CE approved SYR Programmable Syringe Pump, SYR-1400, with KEM-Pump Software Single position syringe pump with KEM-Pump software for PC control (shown on p.11). 120 Vac version SYR-1400 $ System requires the selection of one syringe and valve (below) for operation. 230Vac, CE approved SYR Dual position syringe pump with KEM-Pump software for PC control (shown on p.11). 120 Vac version SYR System requires the selection of two syringes and valves (below), one for each pump. 230Vac, CE approved SYR Syringe Pump Options Built-in digital temperature controller. Controls the temperature of an attached piece of equipment to 0.1 o C. Data logging, PC control, 120 V, 1200 watts I/O Package. Includes 3 high current outputs (170 ma, 24 Vdc), 3 digital TTL inputs, 1 analog input (8 bits, 0-5 Vdc). Control solenoid valves or read input sensors, all under program control. Includes internal power supply. Programmable 120 V outlet. Turns equipment On/Off under program control Vac (12 amp available) Custom Syringe Pumps Program controlled distribution valve provides 32 selectable ports of reagent or reactor access. System sequentially delivers 20 reagents and solvents, or mixture of any combination of reagents. PC software runs 1024 unattended experiments with data logging and flushing of the reactor cell. Heated syringe Syringes (one needed for each syringe module) Description Cat # Price 10 µl glass syringe with Teflon plunger SPGS-10 $ µl glass syringe with Teflon plunger SPGS µl glass syringe with Teflon plunger SPGS µl glass syringe with Teflon plunger SPGS µl glass syringe with Teflon plunger SPGS µl glass syringe with Teflon plunger SPGS ml glass syringe with Teflon plunger SPGS ml glass syringe with Teflon plunger SPGS ml glass syringe with Teflon plunger SPGS ml glass syringe with Teflon plunger SPGS ml glass syringe with Teflon plunger SPGS ml glass syringe with Teflon plunger SPGS ml glass syringe with Teflon plunger SPGS Teflon Distribution Valves (one needed for each syringe module) 3-Port distribution valve (syringe + 3 addressable ports) 4-Port distribution valve (syringe + 4 addressable ports) 6-Port distribution valve (syringe + 6 addressable ports) 8-Port distribution valve (syringe + 8 addressable ports) Teflon Tubing & Fittings Startup Kit. 20 feet 1/8 OD tubing, 12 nuts & ferrules Startup Kit. 100 feet 1/8 OD tubing, 24 nuts & ferrules Startup Kit. 20 feet 1/16 OD tubing, 12 nuts & ferrules Startup Kit. 100 feet 1/16 OD tubing, 24 nuts & ferrules SYR-DTC $ SYR-I/O SYR-120V SPDV-3 $ SPDV SPDV SPDV SP-SK1 $ SP-SK SP-SK SP-SK Dimensions: SYR x3.5 x13 (HxWxD) Flow rates: 0.75 µl/min to 375 ml/min SYR x7 x13 (HxWxD) Accuracy: 0.33% CV, full stroke Pressure Limit: 80 psi Precision: 0.007% full stroke Microfluidic reaction system provides continuous delivery of 24 reagents and solvents to a heated reactor. PC control automates 1000 reaction combinations Eight independent half-size syringe pumps Custom pump drives 4-48 syringes in parallel. See page 8. J-KEM Scientific Toll-free: (800) Fax: (314) [email protected] Page 13

16 Custom... Automate the addition of reagents based on: Time Temperature ph Pressure The Reaction Controller has all the features and runs all of the programs of the model SYR-1200 syringe pump (page 10). In addition, the Reaction Controller has integrated thermocouple and ph inputs expanding its capabilities to add reagents not just as a function of time, but also, temperature, and ph. Common applications include maintaining a constant solution ph during the course of a reaction, or adjusting the addition rate of a reagent as a function of reaction temperature. J-KEM also offers custom programming at no additional charge to meet the unique requirements of your application. Programmable Reaction Controller Description Cat # Price Reaction Controller with Thermocouple Input Syringe pump with thermocouple input adds multiple reagents as a function of time and temperature. Logs all reaction parameters to internal memory or PC. Requires the selection of one syringe and valve from page 13 for operation. Reaction Controller with Thermocouple and ph Input Syringe pump with thermocouple and ph inputs adds multiple reagents as a function of time, temperature and/or ph. Logs all reaction parameters to internal memory or PC. Requires the selection of one syringe and valve from page 13. INF-RC-T INF-RC-TP $ Options Digital Temperature Controller Channel Digital temperature controller built into the Reaction Controller regulates the temperature of the addition reaction. Digital Pressure Monitor Monitors the pressure of the addition process. Use to add reagents as a function of pressure or to stop addition if pressure reaches a user set safe limit. Selectable pressure ranges. Contact J-KEM for pressure range options. Controls 4 independent reactions: Temperature (-20 to 100 o C) Stir rate and torque Addition sequence and rate of 12 reagents PC control and data logging Reaction Controller Let J-KEM design a fully automated reaction system for your lab. We automate reaction setups involving weighing, reagent delivery, temperature control, mixing, pressure control, and any other feature. Combined with custom Windows software, J-KEM can make the perfect reaction system for your research needs. Page 14 Examples of Custom Reactors Titer Point Device Automatically finds the titer point of fatty acids o C resolution Programmable heating and cooling rates Range: -20 to 100 o C Four place, independently heated and cooled reaction system. PC control with data logging. Temperature range: -20 to 100 o C Catalyst Testing Station J-KEM Scientific Toll-free: (800) Fax: (314) [email protected] SYR-DTC $ SYR-PSI Controller prepares and charges reactor with substrate and reagents to sequentially run 1000 unattended reactions testing catalyst longevity. Catalyst activity is determined by the addition rate of base needed to maintain a constant ph.

17 Something unusual from a scientific instrument company From the beginning, J-KEM has worked to be part of the research community, rather than just a supplier to the research community. That s why J-KEM offers substantial Academic discounts on every item we sell, because we believe that supporting the next generation of researcher is part of our corporate responsibility. J-KEM s Continuous Flow Reactor continues that commitment by supplying the high quality instruments that are needed for research today. At the time this catalog was printed, our continuous flow reactor was still in development, but even in development, its performance and features so significantly exceeded those of any other flow reactor that we decided to provide a preview of what s coming. Continuous Flow Reactor J-KEM s continuous flow reactor can be configured to operate in either of two modes, reaction discovery mode or preparative synthesis mode. In discovery mode, a homogeneous mixture of reaction materials are loaded into a sample injection loop which are then injected into the flow reactor. The reactants flow through the reactor being pushed forward by a continuous stream of clean solvent. While the reactants from the first injection are in the reactor, the reactants for a second injection are being measured out and mixed by a robotic workstation that both prepares reactants for injection and acts as a fraction collector for the reaction products as they elute. Up to 128 reactions can be fully automated without requiring operator intervention. In discovery mode, mg of products are typically produced in each experiment. Fully automated operation runs up to 128 unattended reactions Prepares reactant mixtures and loads the sample loop Controls timing of reactant injections and product collection Program control of flow rate and reactor temperature J-KEM s continuous flow reactor can also be configured to run in preparative mode to produce gram quantities of reactants. In prep mode, the reactants are continuously pumped into the reactor in the desired ratios by adjusting the flow rate of the two reactant pumps. This method was used to run the reaction shown at the left, which resulted in the preparation of 1.94 g of the aryl amine during a 3.5 hour run. Reactor Features Multiple reactor options: - Stainless steel, Inconel, PEEK, PTFE - Tube OD s of 1/16 and 1/8 - Tube ID s from 0.02 to Reactor volumes from 1 ml to 20 ml Flow rates from 0.01 to 5.0 ml/min High pressure (4000 psi) pump Temperature range from RT to 300 o C Back pressure regulators from 100 to 1000 psi Manual or fully automated operation J-KEM Scientific Toll-free: (800) Fax: (314) [email protected] Page 15

18 Heat, Cool, Reflux Add reagents Sample reactions in an inert atmosphere Personal Reaction Station Built-in Magnetic Stirring MedChem Synthesis in a Parallel Format The Personal Reaction Station has every feature needed for lead development and high throughput applications. The reactor provides precise temperature control, powerful magnetic stirring, and an inert atmosphere for each reaction tube. Reactions Remove individual reactions are run in 50 ml glass without disturbing the atmosphere in any other tube tubes that fit inside a heated and cooled reactor base. Six built-in magnetic stirrers provide uniform stirring even for viscous and heterogeneous reactions. A reflux condenser plate surrounds the midsection of each reaction tube providing for a continuous reflux with no cross contamination or solvent loss. Reactors connect to an inert gas manifold through separate needle valves and quick disconnect fittings, allowing individual reactors to be removed without disturbing the atmosphere in other reactor. All reactors have Teflon septum needle ports for adding reagents and for sampling the reactor content. Custom reactor with inputs for thermocouple and reagent addition tube for each reactor. For reaction volumes from 0.5 to 8 ml, J-KEM offers a limited volume reactor and heat transfer ring. Provides homogeneous heating and reflux for small volume reactions. Personal Reaction Station Description Cat # Price Personal Reaction Station Includes reactor with built-in magnetic stirrers, twelve 50 ml 120 Vac version: PRS-120R $ glass reaction tubes, six Tefl on reactor plugs, septum fi ttings and magnetic stirring bars. Requires Model PRS-T digital temperature/stirring controller. 230 Vac version, CE: Digital Temperature and Stir Rate Controller for Personal Reaction Station. Controller adjusts 120 Vac version: both the stirring rate and reaction temperature. Digital controller provides precise temperature regulation (±0.1 o C), temperature ramping, and J-KEM enhanced RS232 serial communications for remote controller and data logging applications. 230 Vac version, CE: Reduced Volume Kit Tapered glass reaction tubes for solution volumes from 0.5 to 8 ml. Reduced volume tube fits in a heat transfer ring for homogeneous heating. Includes six glass reaction tubes and six heat transfer rings. 50 ml Glass Reaction Tubes Glass reaction tubes with Teflon lined caps. (Package of 36) 10 ml Glass Reaction Tubes Reduced volume glass reaction tubes with Teflon lined caps. (Package of 6) Evaporator Head for Personal Reaction Station Evaporator injects streams of nitrogen gas into each reaction tube. External Temperature Probe Insert Tefl on probe into one reactor to regulate solution temperature. Replacement Teflon Septa Septa for syringe injection port. (Package of 48) Replacement Septum Fittings Threaded fi tting secures Teflon septum into reaction head. (Package of 12) Replacement Reactor Plug Tefl on plug fi ts inside reaction tube forming an air tight seal. Includes cap Replacement Inert Gas Lines Inert gas delivery lines and quick connect fittings. (Package of 6) Teflon Stirring Bars Tefl on coated star stirring bar optimized for PRS tubes. (Package of 6) PRS-230R PRS-T PRS-T PRS-RDK KPS50-GT PRS10-GT PRS-VAP PRS-RTD PRS-SEP PRS-SF PRS-TP PRS-IL PRS-MSB Reactor Specifications: Temperature range: -80 to 130 o C Temperature variation: ±0.5 o C Stirring speed: rpm Condenser efficiency: 2% loss of CH2Cl2 after 7 days at reflux Page 16 J-KEM Scientific Toll-free: (800) Fax: (314) [email protected]

19 KEM-Prep Parallel Reactor Glass reactors Inert atmosphere Heat, Cool, Reflux Add reagents - Sample reactions - in an inert atmosphere Temperature range: -80 to 130 o C Built-in condenser refluxes 24 reactions Inert gas swept interior KEM-Prep reactor shown with model KLS-150/T temperature controller KEM-Prep Jr. Classical Synthesis in a Parallel Format The KEM-Prep and KEM-Prep Jr. reactors are ideally suited for lead development or high throughput applications. Reactions are run in either 25 or 50 ml glass reaction tubes which fit inside the heated and cooled reactor base. A reflux condenser plate surrounds the midsection of each tube enabling a continuous reflux with no cross contamination or solvent loss. Reactors are maintained in an inert atmosphere while reagents are added through a Teflon septa port. Mixing is achieved by mounting the reactor on J-KEM s bench top shaker. The KEM-Prep reactor holds 24 reaction tubes while the KEM-Prep Jr. holds 6 tubes. KEM-Prep reactor shown with optional solvent evaporator KEM-Prep Reactors Description Cat # Price KEM-Prep Reactor for 25 ml reaction Tubes. Includes 24-position KEM-Prep reactor, 36 glass reaction tubes, and KPS25-120R $ Tefl on septum sheet. Requires a KLS temp. controller (see below). 120 V. Available for 230 V, CE approved KEM-Prep Reactor for 50 ml reaction Tubes. Includes 24-position KEM-Prep reactor, 36 glass reaction tubes, and KPS50-120R Tefl on septum sheet. Requires a KLS temp. controller (see below). 120 V. Available for 230 V, CE approved KEM-Prep Jr. Reactor for 25 ml reaction Tubes. Includes 6-position KEM-Prep Jr. reactor, 12 glass reaction tubes, KPJ25-120R and Tefl on septum sheet. Requires a KLS temp. controller (see below). 120 V. Available for 230 V, CE approved KEM-Prep Jr. Reactor for 50 ml reaction Tubes. Includes 6-position KEM-Prep Jr. reactor, 12 glass reaction tubes, KPJ50-120R and Tefl on septum sheet. Requires a KLS temp. controller (see below). 120 V. Available for 230 V, CE approved Temperature Controllers Digital Temperature Controller for KEM-Prep Reactor. Temperature ramping and 0.1 o C regulation. RS232 optional Digital Temperature Controller with 100 Hour Timer for KEM-Prep Reactor. Temperature ramping and 0.1 o C regulation. 100 Hour timer turns heating On/Off at user set time. RS232 serial port for PC control is optional. KLS-150 $ KLS-150/T Accessories Evaporation Head for KEM-Prep Reactor Evaporator fi ts on top of reactor base and directs a jet of nitrogen gas into each of the 24 reactors through a stainless steel needle. Needle height above solvent front is adjustable. Evaporation Head for KEM-Prep Jr. Reactor Evaporator fits on top of reactor base and directs a jet of nitrogen gas into each of the 6 reactors through a stainless steel needle. Needle height above solvent front is adjustable. Replacement Teflon Septum Sheet for KEM-Prep reactor. Replacement Teflon Septum Sheet for KEM-Prep Jr. reactor. 25 ml Glass Reaction Tubes. Package of 36 tubes with Teflon lined caps. 50 ml Glass Reaction Tubes. Package of 36 tubes with Teflon lined caps. Shakers and Mounting Plates Digital Bench Top Shaker for mixing KEM-Prep reactor (see p. 19). Requires KPS-MP or KPJ-MP mounting plate. Analog Bench Top Shaker for mixing KEM-Prep reactor (see p. 19). Requires KPS-MP or KPJ-MP mounting plate. KEM-Prep Shaker Mounting Plate. Secures the reactor to the bench top shaker platform for mixing. KEM-Prep Jr. Shaker Mounting Plate. Secures the reactor to the bench top shaker platform for mixing. KPS-VAP $ KPJ-VAP KPS-SEP KPJ-SEP KPS25-GT KPS50-GT BTS-3500 $ BTS KPS-MP KPJ-MP J-KEM Scientific Toll-free: (800) Fax: (314) [email protected] Page 17

20 Reaction Block Index Single temperature zone blocks p. 18 Multi-temperature zone blocks p. 22 Custom reaction blocks p. 20 Reaction block accessories p. 19 Reaction Blocks Three Styles of Reaction Blocks to choose from: Heated Heated & Cooled Reflux Built-in internal heater for rapid and homogeneous heating Reaction Block Evaporators Built-in heater and internally milled coolant flow path surrounding every vial. Cooling is provided by a circulating chiller. Three layer block. Heated bottom layer, cooled top layer, and insulating middle layer. Cooled top (condenser) maintains reflux in a capped vial. Cooling can be added to the heated bottom layer (optional) to provide heating, cooling, and reflux in the same block. Reaction blocks are an efficient way to provide uniform heating and cooling for multiple reactions. Temperature homogeneity of ±1 o C Temperature range: -80 to 130 o C Efficient mixing, even for heterogeneous mixtures Evaporators fit on top of the reaction block directing jets of nitrogen gas into each individual vial. Heating and gently shaking the block evaporates solvents in a fraction of the time needed by other methods. Heated Reaction Blocks Description Cat # Price Heated block for 2 ml vial size (12 x 32 mm vial). 96 vial positions in an 8 x 12 array RB-2 $ Heated block for 4 ml vial size (15 x 45 mm vial), 1 dram. 96 vial positions in an 8 x 12 array RB Heated block for 8 ml vial size (17 x 60 mm vial), 2 dram. 96 vial positions in an 8 x 12 array RB Heated block for 20 ml vial size (28 x 61 mm vial). 63 vial positions in a 7 x 9 array RB Heated and Cooled Reaction Blocks Heated and Cooled block for 2 ml vial size (12 x 32 mm vial). 96 vial positions in a 8 x 12 array RBC-2 $ Heated and Cooled block for 4 ml vial size (15 x 45 mm vial), 1 dram. 96 vial positions in a 8 x 12 array RBC Heated and Cooled block for 8 ml vial size (17 x 60 mm vial), 2 dram. 96 vial positions in a 8 x 12 array RBC Heated and Cooled block for 20 ml vial size (28 x 61 mm vial). 63 vial positions in a 7 x 9 array RBC Reflux Reaction Blocks Note: The vial used with a reflux block is twice the size of the block itself. For example, the 4 ml reflux block (RBR-4) uses an 8 ml vial to provide 4 ml sample volume and 4 ml head space for condensation. Refl ux block for 2 ml vial size (15 x 45 mm vial). 96 vial positions in a 8 x 12 array Refl ux block for 4 ml vial size (17 x 60 mm vial), 1 dram. 96 vial positions in a 8 x 12 array Refl ux block for 8 ml vial size (21 x 70 mm vial), 2 dram. 63 vial positions in a 7 x 9 array Refl ux block for 20 ml vial size (28 x 95 mm vial). 63 vial positions in a 7 x 9 array Optional cooling channels added to heated bottom layer. To order, add the suffix -BCP. Example: RBR-8-BCP Evaporators for Reaction Blocks Evaporator for 96 position blocks. Fits RB-2, RB-4, RB-8, RBC-2, RBC-4, RBC-8, RBR-2, RBR-4 Evaporator for 63 position blocks. Fits RB-20, RBC-20, RBR-8, RBR-20 RBR-2 $ RBR RBR RBR BCP RBV-96 $ RBV Reaction blocks for custom vial sizes or configurations are available. Contact J-KEM for information. Page 18 J-KEM Scientific Toll-free: (800) Fax: (314) [email protected]

21 The Complete Reaction Block System Consists of: ) Any style reaction block 2) Bench top shaker 3) Reaction block thermocouple 4) Temperature controller Rotary Shakers J-KEM offers both a digital and analog shaker specifically designed to handle the high temperatures and weights of our reactions blocks. 10% discount on shakers when ordered with a reaction block Rotary Bench Top Shakers Description Cat # Price Digital bench top shaker for reaction blocks. Digital speed control. BTS-3500 $ Continuous operation or 100 hr. timer, unbalance sensor. 120 V Analog bench top shaker for reaction blocks. Rotational speed set via BTS front panel dial. Continuous operation or 1 hr. timer. 120 V Analog bench top shaker. Same as BTS-1500, 230 V, CE approved BTS Digital BTS year warranty Analog BTS-1500 Specifications: BTS-3500 BTS-1500 Rotational speed: rpm rpm Orbital diameter: Load capacity: 35 pounds 35 pounds Timer duration: 100 hr. 1 hr. Unbalance sensor: Automatic stop None RS232 serial interface: Yes No Certifications: UL, cul, CE UL, cul, CE Dimensions: 17.4 x 13.5 x 6.4 Weight: 35 lb. Temperature Controllers All J-KEM controllers precisely regulate reaction block temperatures. The 200-Series controllers (page 32) are always a good choice providing 0.1 o C regulation of any heater, including reaction blocks. The Model 150 controller is an affordable alternative which also provides 0.1 o C regulation of reaction blocks. The Model 150 is available with or without a 100 hr. timer to turn heating On/Off at a user set time. Optional RS232 serial communications for PC control and data logging (page 36). Digital Temperature Controllers. Model 150 Description Thermocouple Range ( o C) Cat # Price Model 150 temperature controller with ramp-to-setpoint digital meter. 120 V, 1200 watts. Model 150/Timer temperature controller with 100 hr. timer to turn heating On/Off at user set time. Ramp-to-setpoint digital meter. 120 V, 1200 watts. Type T -200 to T $ Type J 0 to J Type K -50 to K Type T -200 to /Timer-T Type J 0 to /Timer-J Type K -50 to /Timer-K Reaction Block Thermocouple Reaction Block Thermocouples Description Cat # Price Spring loaded bayonet thermocouple connects to mating port on the reaction block providing continuous and reliable temperature readings of shaking blocks. RBTC-T RBTC-J RBTC-K Recirculating Chillers Circulating chillers attach to the cooling ports on cooled reaction blocks to provide the cooling to run chilled reactions. Temperature as low as -90 o C. See page 24 for a complete selection. J-KEM Scientific Toll-free: (800) Fax: (314) [email protected] Page 19

22 J-KEM makes custom reaction blocks for virtually any application. Examples of custom blocks from J-KEM. Features include: Built-in stirring Multiple temperature zones High temperatures Multiple vial sizes Custom Reaction Blocks Three temperature zone block (240 o C) secured to a low profile shaker. Used to test the effectiveness of surfactants for oil/water separations 250 ml Erlenmeyer flask block KEM-Lab Reactor (see p. 23) with insert blocks for 4 vial sizes Two temperature zone block for multiple vial sizes Large block for 15 quart jars See-through block for crystallization studies in glass titer plates. High temperature in insulating frame High temperature block (300 o C) inside insulated frame Six temperature zone block for SPS synthesis columns Two temperature zone block for heating & cooling inside insulating frame Heated & cooled reaction block with inserts to fit a selection of vial sizes High temperature block inside insulating frame with inert gas cover Page 20 J-KEM Scientific Toll-free: (800) Fax: (314) [email protected]

23 Custom Solutions for Demanding Chemistry Even more to feed the imagination High temperature see-through block for 4 ml vials. Heated & cooled design. Block on hotplate stirrer for organic chem lab Reflux block for multiple vial sizes Four temperature zone Peltier regulated block for 125 ml bottles Heater with built-in digital controller for DNA hybridization Two heated & cooled pockets built into Gilson rack Half liter block with digital over-head stirrer and digital controller for formulations testing Saponification reactor with high pressure stainless steel reaction tubes. Insulated reactor inside explosion resistant housing Oven for four deep well titer plates. Cover not shown Heated & cooled block inside insulating frame 16-position microtiter plate heater Heated block to mate with multiposition stirrer J-KEM Scientific Toll-free: (800) Fax: (314) [email protected] Page 21

24 Multi-Temperature Zone Reaction Blocks Multi-zone reaction blocks allow independent temperature control of each block position. Each block can be a different style (heated, cooled, reflux) and can fit different size vials. Multi-zone reaction blocks are an indispensable tool for parallel synthesis, process development, and formulations research. 6-Position reaction block with 6-position temperature controller 2, 4, or 6 Independent temperature zones Heat, cool, and reflux capability Multiple vial sizes Ordering a Multi-Zone Reaction Block There are literally hundreds of configurations for 2, 4, and 6-position reaction block systems. For this reason, it s necessary to request a quote that assigns a unique product number to your unique block. To receive a quote, call or a description that answers these questions: Prices The price of a multi-zone block depends on the block style selected for each of the temperature zones (the vial size does not matter). The price of a block can be calculated from this price list. Multi-Temperature Zone Reaction Blocks Description Two zone reaction block Base price for two heated zones: For each cooled zone add: For each refl ux zone add: Four zone reaction block Base price for four heated zones: For each cooled zone add: For each refl ux zone add: Six zone reaction block Base price for six heated zones: For each cooled zone add: For each refl ux zone add: Multi-Position Temperature Controllers Two zone digital temperature controller. Ramp-to-setpoint, USB Four zone digital temperature controller. Ramp-to-setpoint, USB Six zone digital temperature controller. Ramp-to-setpoint, USB Price $ $ Zone block heats 4 titer plates each Number of Vial Positions in Each Zone of a Multi-Zone The number of vials that fit in each Reaction Block temperature zone depends on the vial size and the block style selected. 2-Zone Reaction Block 4-Zone Reaction Block 6-Zone Reaction Block 4-position block with 3 vial sizes 6-zone block for 2 vial sizes. Four heated/cooled positions and 2 heated only positions 1) Do you want a block with 2-, 4-, or 6-temperature zones? 2) What size vial does each block (temperature zone) fit? 3) What style (heated, heated/cooled, reflux) is each block position? 4) Any custom features? Vial spacing, hole depth, special shapes? [email protected] Phone: (800) or (314) Fax: (314) Vial Size: 2 ml 4 ml 8 ml 20 ml Heated style Cooled style Reflux style Heated style Cooled style Reflux style Heated style Cooled style Reflux style Multi-Temperature Pocket Blocks Multi-temperature zone pocket blocks fit aluminum inserts that fit various vial sizes and microtiter plates. Transfer inserts between a robotic deck and the heated pocket block. Purchase insert blocks for any vial size. Page 22 J-KEM Scientific Toll-free: (800) Fax: (314) [email protected]

25 KEM-Lab Parallel Reactors Compact * Convenient * Precise Temperature Control The perfect tool for synthesis, formulations, and incubations KEM-Lab reactors are an ideal addition to a research laboratory. Compact design minimizes the bench space needed Temperature ramping for both heating and cooling Temperature range: -80 to 130 o C Multiple styles: heating, cooling, and reflux KEM-Lab shaker provides vigorous mixing for KEM-Lab reactors. KEM-Lab Reactors for: Titer plates * Vials * Custom racks Three styles of reactors to choose from: Heated * Heated & Cooled * Reflux Heated KEM-Lab Reactors Heated & Cooled KEM-Labs Reflux KEM-Labs Reactor Reactor Reactor fi ts (vial dim.) (# of vials) fits (# of vials ) fits (# of vials) Description Cat # Price Cat # Price Cat # Price 2 ml vial (12 x 32 mm) (24) KLS-2-H $ ml vial (24) KLS-2-C $ ml vial (18) KLS-2-R $ ml vial (15 x 45 mm) (24) KLS-4-H ml vial (24) KLS-4-C ml vial (16) KLS-4-R ml vial (17 x 60 mm) (20) KLS-8-H ml vial (20) KLS-8-C ml vial (12) KLS-8-R ml vial (21 x 70 mm) (15) KLS-16-H ml vial (15) KLS-16-C ml vial (28 x 61 mm) (12) KLS-20-H ml vial (12) KLS-20-C ml vial (6) KLS-20-R Shallow well titer plate (1 plate) KLS-SW-H Shallow (1 plate) KLS-SW-C Deep well titer plate (1 plate) KLS-DW-H Deepwell (1 plate) KLS-DW-C All reactors are for 120 V use. J-KEM s glass titer plate (1 plate) KLS-GP-H Glass (1 plate) KLS-GP-C V reactors available on request. KEM-Lab Reactor Shaker & Accessories KEM-Lab bench top shaker Provides vigorous mixing for KEM-Lab reactors. Specifications: 100 to 2000 rpm. Continuous and pulsed shaking modes. Weight limit: 4 pounds. 120 V. Dimensions: 16 x 7 x 8.75 (WxDxH) KLS-HD $ Septum cover plate provides an air-tight seal and needle access port for each vial in the reactor to add reagents or sample reactions. Includes a Tefl on faced septum sheet. To specify the cover, replace the # in the catalog number with KLS-SC-# the number of vial positions in the block. Example: KLS-SC-12 fits the KLS-20-H, KLS-20-C, and KLS-8-R reactors. Replacement septum sheet Tefl on faced sheet for septum cover. KLS-SEP Digital Temperature Controllers Digital temperature controller for KEM-Lab reactors. Controller provides 0.1 o C regulation of any KEM-Lab reactor. 120 V Optional RS232 communications. KLS-150 $ Digital temperature controller with 100 hour timer. Same as KLS-150 but includes a 100 hour timer to turn heating Off (or On) at a user set time. Optional RS232 port. KLS-150/T Replacement power cable between reactor and KLS controller. KLS-Cable KEM-Lab Reactor Evaporators Evaporation head Fits on top of the reactor to direct a jet of nitrogen gas into each vial. Apply mild heating from the reactor to rapidly evaporate even high boiling point solvents. To specify the evaporator, replace the # in the catalog number with the vial positions in the block. Example: KLS-VAP-20 fi ts KLS-8-H and KLS-8-C reactors. Cat # KLS-VAP- # Price: $ Glass Plates for KLS-GP Reactors J-KEM s glass plates are individual tubes held rigidly in a polypropylene holder. Ideal for compound storage or chemical syntheses that require the chemical resistance of glass. The KLS-GP reactor has milled positions surrounding each tube providing outstanding temperature homogeneity. Volume discounts. Plate with 0.5 ml reactors GP1 $45.95 Plate with 1.0 ml reactors GP Teflon cap mat. Solid plug in each tube for air tight seal KLS-CM Teflon cap mat. Hollow plug for needle penetration KLS-CMX 25.50

26 Circulating Chillers/Heaters J-KEM s circulating chiller/heaters are optimized for use with J-KEM s reaction blocks and parallel equipment. With both pressure and suction pumps, these circulators generate higher pumping pressures to provide rapid heating and cooling of attached equipment. All circulators have digital temperature entry, PID control for 0.05 o C regulation, and over-temperature protection. Models with RS232 serial ports allow PC data logging and control of temperature ramps. Quality in the Details Dual pressure & suction pumps provide high coolant flow rates for rapid cooling Inert gas purge fitting blankets the cooling fluid to prevent condensation build-up Easy temperature entry Large digital display o C chiller with J-KEM s KEM-Prep reactor Programmable Controller Digital Controller Standard Controller Programmable - Stores 10 programs of 50 steps each Yes No No Remote temperature probe option Yes No No Graphic LCD readout Yes Yes No Dual display of set point and actual bath temperature Yes Yes No Serial communications (RS232) Yes Yes No Includes PC control software (data logging, temp. ramps) Yes Yes No Dual pressure and suction pumps Yes Yes No Temperature stability 0.01 o C 0.01 o C 0.05 o C Circulating Chillers Temperature Cooling power at: Pressure and Flow Bath Circulator Series Range ( o C) 0 o -10 o -30 o Suction Pumps Rate Capacity Weight Cat # Price Model 9100 Standard -20 to No 15 lpm 6 liters 60 lb E $ Digital -20 to 200 watts Yes 30 lpm 9100-SC Programmable -20 to 200 Yes 30 lpm 9100-P Model 9500 Standard -30 to No 15 lpm 13 liters 140 lb E Digital -30 to 200 watts Yes 30 lpm 9500-SC Programmable -30 to 200 Yes 30 lpm 9500-P Model 9700 Standard -40 to No 15 lpm 13 liters 150 lb E Digital -40 to 200 watts Yes 30 lpm 9700-SC Programmable -40 to 200 Yes 30 lpm 9700-P Circulating Chillers Accessories Heat Transfer Fluid. Dynatherm is a low viscosity fl uid with a high heat capacity for rapid heat transfer. Dynatherm $ Compatible with water condensation that contaminates other transfer fluids. Range: -50 to 218 o C. 4 L bottle. Cryogenic Transfer Hose. Flexible cryogenic transfer hose connects chiller to external equipment. Length: 5 feet. RC-CTH Temperature range: -90 to 300 o C. Terminal fi tting: 1/8 NPTM (same as reaction blocks). Price for 1 pair. Quick Connect Fittings. Stainless steel fi ttings for rapid connection of cryogenic hose to equipment. Includes a set of RC-QCC fi ttings (1 each on the ends of the inlet and outlet hoses, and 1 each on the inlet and outlet of the equipment). The heat transfer fluid used with the chiller is as important as the chiller itself. A good transfer fluid must remain non-viscous at the lowest possible temperature for efficient cooling. J-KEM s Dynatherm retains its low viscosity even at -50 o C. Tech Note Chiller Specifications Dimensions Power Fluid Series (LxWxH) (@ 120 V) Connections x 8.3 x watts 1/4 NPTF x 15.5 x watts 1/4 NPTF x 15.5 x watts 1/4 NPTF Page 24 J-KEM Scientific Toll-free: (800) Fax: (314) [email protected]

27 Miniature Overhead Stirrer Power Convenience Safety - More power than stirrers 10 times its size and weight! - Sparkless - Sealed housing - 14 Vdc motor - Weighs less than 1 pound! - Hand-sized The light weight of the motor makes it easy to assemble and align the stirrer with the reaction flask Side mount clamp on digital speed controller Efficient stirring of a 5 L flask Compare the Value Manufacturer Model Max Torque Weight Price J-KEM OHS-1 91 in-oz 0.95 pounds $ Cole-Parmer Servodyne (R ) 70 in-oz 11 pounds 1, Arrow Agitator 40 in-oz 10 pounds IKA Eurostar 85 in-oz 9 pounds 1, Glas-Col HST30N 101 in-oz 20 pounds 2, Overhead Stirrer Description Cat # Price Complete System. Includes the motor, digital speed controller, and chuck for 10 mm stirring rod. Motor only for OHS-1 stirrer. Includes 10 mm stirring rod chuck. Digital speed controller only for miniature OHS-1 motor. Replacement inserts to secure 10 mm stirring rods in motor chuck. (Package of 6) Chuck for 6 mm stirring rods. Chuck replaces the standard 10 mm chuck. OHS-1 $ OHS-1M OHS-DSC OHS-P OHS-6C Custom Laboratory Controllers We re glad to work with our customers to make one-of-a-kind instruments for temperature and pressure control. Shown are examples of recent projects. Specifications Input voltage: Vac Voltage to motor: 14 Vdc max Maximum torque: 91 in-oz Rotational speed: rpm Rotational control: 1 rpm Six position temperature controller with three independent digital vacuum regulators Sixteen position temperature controller Four position temperature controller designed to fit on the front face of a research hood J-KEM Scientific Toll-free: (800) Fax: (314) [email protected] Page 25

28 Solid Phase Synthesis Reactor No Mechanical Valves Fully Automated SPS Reactor Solvent is held in the reactor by computer controlled nitrogen back pressure. Single key stroke commands provide the functionality to: Set up a new reaction Mix the reactants and resin Filter & wash the resin Cleave and collect final products The SPS reactor works by pressurizing the reactor base with nitrogen gas until it exactly offsets the pull of gravity. In this way, solvent can be added to a single reactor with none of it dropping through the frit. As reactors are sequentially filled, the SPS computer regulator precisely controls the flow of nitrogen to maintain the reactor s back pressure to psi. Using nitrogen back pressure to hold solvent in the reaction tube eliminates the need for mechanical valves or other mechanical devices which prevents automation of the SPS process. Reactions are mixed by placing the reactor on a bench top shaker, or by increasing the pressure in the base to cause continuous or intermittent bubbling up through the frit mixing the resin and reactants. Reaction setup, mixing, washing, and filtration are accomplished by a single key stroke on the computer pressure regulator. Can be combined with J-KEM s Eclipse robot for fully automated, multi-step SPS reactions. Gas coming up through the bottom frit to promote mixing Automation Ready See J-KEM s solid phase synthesis robot on page 3. SPS reactor with reactor reflux heater and digital temperature controller Reactor Reflux Heater surrounds each reactor to provide heating to the reaction solvent and cooling to the top half of the reactor. Sample concentrator cover Solid Phase Synthesis Reactor. Basic Components Description Cat # Price Reactor Base. Polypropylene base fits collection block and secures reactor top plate. SPS-TB $ Reactor Support Plate with luer fittings to secure 48 SPS reactors. SPS-SP Reactor Support Plate with lure fittings to secure 96 SPS reactors SPS-SP Sample Collection Block positions sample collection tubes beneath reaction tube outlets. Collection blocks are customized to fit your vial or tube. Contact J-KEM with specifications. SPS-CB SPS Pressure Regulator. Computerized controller regulates the back pressure applied to the reaction tubes. Automates reaction setup, resin washing, and sample collection. SPS-REG Pressure Proportioning Valve for SPS pressure regulation. For 48 position reactor. PSV Pressure Proportioning Valve for SPS pressure regulation. For 96 position reactor. PSV-5TEK Waste Valve fi lters reaction tubes and sweeps wash and reaction solvents to waste. SPS-WV Inlet Gas Pressure Regulator. High flow rate nitrogen gas inlet pressure regulator. SPS-HCR SPS Reactors Fritted SPS Reactor, 6 ml capacity, PP column with 20 µm PE frit. (Package of 100) Fritted SPS Reactor, 12 ml capacity, PP column with 20 µm PE frit. (Package of 100) Fritted SPS Reactor, 35 ml capacity, PP column with 20 µm PE frit. (Package of 100) Fritted SPS Reactor, 60 ml capacity, PP column with 20 µm PE frit. (Package of 100) Optional SPS Components Reactor Reflux Heater. Heats the bottom half of each reaction tube, and cools the top half with a chilled condenser plate to create a sustained reflux inside the reaction tubes. Reactor Port Plugs. Male luer plug seals unused reactor positions. (Package of 12) Replacement O-ring for reactor base. Teflon impregnated AFLAF. Short Reactor Base. Useful for robotic systems to minimize height of reactor. Inert Gas Reactor Cover. Creates an inert atmosphere for all reactors, septum port access. SPS Concentrator Components Concentrator for 48-position SPS system directs a jet of N2 gas into each collection tube. Concentrator for 96-position SPS system directs a jet of N2 gas into each collection tube. Nitrogen Gas Heater warms the N2 to promote faster evaporation. Includes controller (p. 29) SPS-RX6 $ SPS-RX SPS-RX SPS-RX SPS-RB $ SPS-PP SPS-ORING SPS-SB SPS-EC SPS-CC48 $ SPS-CC NGH Page 26 J-KEM Scientific Toll-free: (800) Fax: (314) [email protected]

29 KEM-Vap Solvent Evaporator Evaporate solvents from: Deepwell plates Vial racks Gilson racks Custom Racks Evaporates both volatile and nonvolatile solvents Fast Efficient Solvent Evaporation The KEM-Vap Solvent Evaporator uses heated nitrogen gas and variable vacuum pressures to rapidly evaporate volatile and nonvolatile solvents in the same evaporator. The evaporator cover directs a jet of nitrogen gas into each cell of a titer plate or vial in a vial rack for uniform and consistent evaporations. For nonvolatile solvents, a combination of vacuum and heated nitrogen removes solvents in a fraction of the time needed when vacuum or heated gas is used alone. Made from stainless steel and ultra high density polypropylene the evaporator is not harmed by organic or aqueous solvents. Custom evaporators made on request. Acetone DMSO TFA DMF Water SC4 Gilson rack evaporator KEM-Vap SOLVENT EVAPORATOR Description Cat # Price Solvent concentrator base for 4 deep well SC1 $ plates. Solvent concentrator base for 4 shallow well SC plates. Solvent concentrator base for 1 Gilson rack. SC Solvent concentrator base for 1 deep well plate. SC Insert blocks for SC1 to elevate shallow well SC-IN plates for evaporation. (Set of 4) Solvent evaporator cover for SC1 & SC3. SC For 96-position titer plates. Solvent evaporator cover for SC1 & SC3. SC For 48-position titer plates. Solvent evaporator cover for SC1 & SC3. SC For 24-position titer plates. Solvent evaporator cover for SC4. SC Solvent evaporator cover for SC5. SC For 96-position titer plates. High capacity vacuum solvent trap. Dry ice SC trap with 1000mL receiving fl ask. Nitrogen gas heater. Includes digital NGH temperature controller. See p. 29 for details. SC5 Single plate evaporator Nitrogen gas heater Need Custom Solvent Evaporators? Contact J-KEM to design a solvent evaporator for any rack or application KEM-Lab evaporators on page 23 Reaction block evaporators on p. 18 J-KEM Scientific Toll-free: (800) Fax: (314) [email protected] Page 27

30 Laboratory Safety Instruments Lab Safety Controller NEW USB Communications & GLP/GMP software Protects against: Coolant flow failure Over-temperature condition Under-temperature condition - Protects against flask breaking or TC falling out of the flask. Digital Temperature Monitor NEW USB Communications & GLP/GMP software Water Flow Monitor The Lab Safety Controller combines all the features of J-KEM s Digital Temperature Monitor and Water Flow Monitor, then adds a temperature limit controller into a single versatile instrument. Plug any piece of equipment into the monitor, then if the water flow rate falls below the user set level, or the reaction temperature goes above or below the set limits, outlet power is turned off until the controller is manually reset. The controller also disconnects power following recovery from a power failure. USB communications and free KEM-Net software provide GLP/GMP data and alarm logging. Description TC Type Cat # Price Lab Safety Controller. 120 V, 1800 watts. T Requires a flow sensor. J K Lab Safety Controller. 230 V, 2300 watts. Flow sensor. Flow rate: 0.1 to 2.5 L/min Flow sensor. Flow rate: 1 to 10 L/min Flow sensor. Flow rate: 2 to 30 L/min Water shut off valve. Turns off flow during an alarm Digital Alarm Outlet. Open collector (170 ma) outlet Specifications: Dim x 5.25 x 7.25 (H x W x D). USB 2.0 Monitors and displays the temperature of an attached piece of equipment on a bright LED display. Built-in USB 2.0 serial communications and free KEM-Net data logging software (page 37) provides remote temperature monitoring and records time & temperature data to a GLP/GMP compliant log file. Kem-Net provides notification of an over or under-temperature condition. Large digital display 0.1 o C Resolution Optional audible alarm Description TC Type Range ( o C) Cat # Price Digital Temperature Monitor T -200 to 250 DM120-T $ Vac input. USB communications J 0 to 800 DM120-J with KEM-Net data logging software K -50 to 1200 DM120-K Digital Temperature Monitor T -200 to 250 DM230-T Vac input. USB communications J 0 to 800 DM230-J with KEM-Net data logging software K -50 to 1200 DM230-K Specifications: 120 or 230 Vac input, 50 watts USB 2.0 Dim. 2.5 x 3.75 x 5.4 (H x W x D) Precisely monitors the flow rate of water through a condenser, water bath, or other piece of equipment. If the flow rate falls below the minimum rate set by the user (i.e. loss of pressure, broken hose), power is turned off to the monitor s output receptacle and any equipment plugged into it. Power remains off until being manually reset. The optional water shut off valve stops water flow during an alarm condition preventing a flooded lab. With safety as its primary goal, the J-KEM Water Flow Monitor measures the actual water flow rate, rather than back pressure as in commonly measured by lower quality instruments. Digital sensor measures actual coolant flow rate Optional audible and digital alarms LS-120T $ LS-120J LS-120K LS-230K WFM WFM WFM WV WFM-OC Prevents heating accidents due to water flow failures Description Cat # Price Water flow monitor. 120 V, 1800 watts. Requires a flow sensor. WFM-120 $ Water flow monitor. 230 V, 2300 watts. Requires a flow sensor. WFM Flow sensor. Flow rate: 0.1 to 2.5 L/min WFM Flow sensor. Flow rate: 1 to 10 L/min WFM Flow sensor. Flow rate: 2 to 30 L/min WFM Water shut off valve. Turns off water flow during an alarm. 250WV Audible Alarm. Alarm (70 db) sounds during under flow condition. WFM-AA Digital Alarm Outlet. High current (170 ma) open collector output. WFM-OC Specifications: Dimensions: 2.5 x 3.75 x 5.4 (H x W x D) Page 28 J-KEM Scientific Toll-free: (800) Fax: (314) [email protected]

31 Trinity Power Controller Solid state electronics makes this variac the perfect instrument for research, and is especially useful in teaching labs. Safety features include sparkless solid state regulation of voltage for oil baths, heating mantles, heat lamps, and many other devices. Offered in two configurations, the Trinity-1 replaces an existing receptacle for installation directly in hoods or other outlets. The Trinity-2 comes in its own case with an attached power cord. Both the Trinity-1 and Trinity-2 are offered with and without a built in analog voltage meter. Trinity-1 Laboratory Safety Instruments Installs in hood Nitrogen Gas Heater Trinity-2 J-KEM s Nitrogen Gas Heater regulates the temperature of nonflammable gases providing an intrinsically safe heat source for safety critical laboratory applications. An ideal instrument for solvent evaporation or for any heating application where a traditional heater is unsafe or inconvenient to use. Includes a digital temperature controller for 0.5 o C regulation of outlet gas temperature. A minimum flow rate of 1 liter/minute must be maintained when power is applied to the heater. To avoid burning out the heater element, an optional flow switch can be built into the heater to turn power off when gas flow falls below the minimum safe level. Handheld Meter & Data Logger Intrinsically safe heating, even for flammable substances Replace an existing electrical outlet Convenience of a built-in variac Frees up bench space Solid state design Affordable price Trinity Power Controller Installs Built-in in Hood Meter Cat # Price* Yes** Yes Trinity-1M $ Yes** No Trinity-1P No Yes Trinity-2M No No Trinity-2P Specifications: 120vac, 5 amps, 600 watts * Academic and volume discounts ** Requires junction box depth Maximum Gas Temperature as a Function of Flow Rate Maximum Temperature ( o C) Air Flow Voltage: 120 V 230 V (L/min) 700 watts 900 watts 2000 watts Nitrogen Gas Heater Description Cat # Price Heater with digital controller, 120 Vac. 700 watt heater core. NGH-120 $ Heater with digital controller, 120 Vac. 900 watt heater core. NGH Heater with digital controller, 230 Vac watt heater core. NGH Accessories Flow switch turns heating off if air flow falls below a minimum safe rate. NGH-FS Specifications: Temperature range: See chart above Minimum flow range: 1 liter per minute Fittings: 3/8 female NPT These versatile meters provide convenient temperature readings from a variety of thermocouples. Features include two thermocouple inputs, large dual temperature displays, data logging and automatic MIN/MAX temperature storage. Data can be transferred in real-time or after a run is complete on the optional PC interface. Feature HHM-20 HHM-40 Thermocouples T, J, K, E T, J, K, E Resolution 0.1 o 0.1 o Data points stored Optional printer No Yes Scale o F and o C Yes Yes Automatic MIN/Max Yes Yes Built-in stand Yes Yes Hand Held Temperature Meters Description Cat # Price Dual channel hand held meter HHM-20 $ Dual channel meter with extended memory to store 1000 data points HHM Hand Held Meter Options RS232 interface for PC data logging HHM J-KEM Scientific Toll-free: (800) Fax: (314) [email protected] Page 29

32 Features: * No Mercury Digital Vacuum Regulator 100% digital pressure entry and control Wetted parts are 100% stainless steel and Teflon Vacuum ramping feature eliminates bumping USB port and free software for PC control Resists: All organic solvents Acids Bases Water The Digital Vacuum Regulator is an ideal instrument for laboratory vacuum regulation. Connect the regulator to any vacuum pump or vacuum source and then to any piece of equipment to regulate pressure in most cases to ± 1 torr. A pressure ramp feature (standard) evacuates equipment at a user defined rate to eliminate bumping due to solvent degassing or over-evacuation. The vacuum regulator is ideally suited for large volume distillations, rotary evaporators and vacuum chambers. The DVR-200 is not recommended for small volume distillations or applications which involve a continuous purge with gas. These are better performed by J-KEM s Precision Vacuum Regulator, the DVR Recover > 99% of solvent from rotary evaporators DVR Pressure Solvent Time to Percent Solvent (mm Hg) Volume Dryness Recovery Ether 475 torr 340 ml 14.6 min 99.6% CH 2 Cl torr 360 ml 21.9 min 99.8% CH 2 Cl torr 255 ml 5.9 min 99.5% EtOAc 90 torr 316 ml 17.0 min 99.9% Toluene 50 torr 273 ml 15.7 min 99.4% A Note About Quality J-KEM uses the highest quality components available. For example, most vacuum controllers use a silicone filled vacuum transducer (because they cost less), but J-KEM uses a stainless steel diaphragm transducer. Also, rather than a standard vacuum valve with Viton seals, J-KEM uses a custom stainless steel valve with Teflon seals. These, and other enhancements provide the chemical resistance needed in chemistry laboratories. Digital Vacuum Regulators and Monitors Description Cat # Price Vacuum Regulator, Model DVR-200. Includes built-in SS transducer. 120V DVR-200 $ Vacuum Regulator, Model DVR-300. Same as DVR-200 but for 230V. CE Approved. DVR Vacuum Regulator, Model DVR-280. SS transducer and pump controller. 120V DVR Vacuum Regulator, Model DVR-380. Same as DVR-280 but for 230V. CE Approved. DVR Vacuum Regulator with large capacity valve for large volume equipment. Call Digital Vacuum Monitor. Continuous display of system pressure, no regulation. 120V DVM Digital Vacuum Monitor. Same as DVM-100 but for 230V. CE Approved. DVM Vacuum Regulator Accessories Stainless Steel Needle Valve. Improves regulation in small pieces of equipment. Analog pressure output. External 0-20 mv analog output. Useful for data logging. Condenser body for dry ice condenser. 35/25 joint. Condenser receiving flask ml fl ask with 35/25 joint. Condenser receiving flask ml fl ask with 35/25 joint. Specifications: 120 & watts. Vacuum fittings: 1/8 NPTM. Two Styles of Regulator to Choose From DVR-200 The DVR-200 is designed for continuous vacuum sources, such as oil-filled vacuum pumps, aspirators, or systems that are always on, like in-house vacuum systems. The DVR-200 regulates pressure by opening and closing a valve that separates the vacuum source from the system being evacuated. In most cases, the DVR-200 is the best choice. DVR-280 The DVR-280 is designed for use with diaphragm vacuum pumps. In some systems, pressure is regulated by turning on and off the vacuum pump itself. The DVR-280 extends the life of diaphragm pumps by not exposing the diaphragm to full vacuum pressures when starting, which increases pump life by 100%. NEW!! USB + Free KEM-Net software. (see p. 37) DVR-PNV $ DVR-JH JCE MTE MTE Dim. 3.4 x 5.4 x 7.4 (HxWxD) * Academic discounts. Warranty: Electronics: 2 yr; transducer and vacuum valve: 6 mo., but void if due to chemical buildup. Dry ice trap JCE-1000 Page 30 J-KEM Scientific Toll-free: (800) Fax: (314) [email protected]

33 Precision Vacuum & Pressure Regulators Precise regulation of ±0.1 torr of volumes as small as 1 ml Perfect for vacuum distillations Automatically compensates for leaks in the equipment under test Maintains constant precise pressure, even in systems with a continuous gas purge Standard Features: 16-Step programmable pressure ramp Serial communication for PC control and logging 0.1 Torr Regulation - No Mercury J-KEM s computer (built-in) controlled vacuum and pressure regulators maintain pressure to 0.1 torr in test instruments with volumes as small as 1 ml. Built from J-KEM s Infinity Computer, this series of instruments can be customized to automate virtually any laboratory or quality control task involving the regulation of vacuum or pressure. The DVR-1000 regulates vacuums, the DPR-1100 regulates positive pressures, and the DDR-1200 regulates both vacuum and positive pressures. Custom Features: Custom programming to meet any research requirement Add a temperature control channel. Add User programmable digital and analog inputs and outputs Use the built-in Infinity computer to automate a complex test sequence or any process involving pressure control Precision Vacuum and Pressure Regulators Description Cat # Price Digital Vacuum Regulator. Precise regulation of vacuum pressures in the range of 0.1 to torr (atm pressure). Requires the selection of one PSV valve (below) Digital Pressure Regulator. Precise regulation of positive pressures in the range of 0 psi (atm pressure) to 50 psi. The maximum pressure of the controller is user DVR-1000 $ DPR-1100-# selectable. Replace the # in DPR-1100-# with the selected maximum pressure. Ranges: 1, 5, 15, 30, 50 psi. Requires the selection of one PSV valve (below). Gage transducer is standard, but absolute is available on request. Dual Range Vacuum & Pressure Regulator. Precisely controls both vacuum and positive pressures. The DDR-1200 is built with a dual range pressure transducer DDR-1200-# capable of accurately measuring pressures from full vacuum to the pressure limit of the transducer selected. The maximum pressure of the controller is user selectable. Replace the # in DDR-1200-# with the selected maximum pressure above ATM. Ranges: 15 and 35 psi. Requires the selection of two PSV valves (below), one for vacuum and one for pressure regulation. Contains an absolute pressure transducer. Back-Fill Option. The DVR-1000 and DPR-1100 can be equipped to operate a second valve used to back fi ll the evacuated or pressurized reactor. Requires the selection of a second PSV valve (below). OPT-DV Stainless Steel Proportioning Valves The optimal PSV value depends on the exact conditions of the procedure. The volume guides below are helpful for closed systems. For applications with a continuous purge of gas, call J-KEM for assistance. Proportioning Valve. Microfl ow proportioning valves, call to discuss your application. Proportioning Valve. For reactor volumes: 1 ml to 2 L Cv: Orifice: Proportioning Valve. For reactor volumes: 25 ml to 4 L Cv: Orifice: Proportioning Valve. For reactor volumes: 100mL to 22L Cv: Orifice: Proportioning Valve. For reactor volumes: 1 L to 50 L. Cv: 0.12 Orifice: Proportioning Valve. Large capacity valve. Cv: 0.37 Orifice: Proportioning Valve. Large capacity valve. Cv: 0.7 Orifice: Proportioning Valve. Large capacity valve. Cv: 1.3 Orifice: Proportioning Valve. Large capacity valve. Cv: 2.0 Orifice: PSV-Micro Call PSV-2 $ PSV PSV PSV PSV-5TEK PSV PSV PSV Specifications: Transducer Diaphragm: Stainless steel Accuracy: DVR-1000: 0.1% DPR-1100: 0.25% DDR-1200: 0.25% Proof Pressure: 200% Controller Regulation: 0.015% of range Resolution: 0.1 torr or 0.01 psi Vapor Path Materials: Stainless steel and Teflon Ramp Rates: 100 torr/sec to 0.1 torr/hr. Serial Communications: RS232 (RS485 or USB on request) Power: 100 watts. Fittings 1/4 SS Compression fittings Warranty: Electronics: 2 years. Transducer and proportioning valve is 6 mo. but void if failure is due to chemical buildup. J-KEM Scientific Toll-free: (800) Fax: (314) [email protected] Page 31

34 Model 210 Digital Temperature Controllers The Model 210 is J-KEM s most compact, research-grade controller, yet packed with 1200 watts of power. Sufficient for heating mantles up to 5 L in size and most laboratory ovens, hot plates, reaction blocks and other heaters. Contains J-KEM s patented power control computer which provides 0.1 o C regulation of anything. 0.1 o C Regulation & Display 230VAC, CE approved Model 310 available NIST traceable Advanced PID algorithm Controller Only Complete System Cat # Price* Cat # Price* 210-T $ T-S $ J J-S K K-S Model 210/Timer NEW!! USB port and Free KEM-Net data logging & control software Thermocouple Temperature Type Range ( o C) T -200 to 250 J 0 to 800 K -50 to 1200 RTD -200 to Pt Pt-S Specifications: 120vac, 10 amps, 1200 watts. Dim x 5.25 x 7.4 (HxWxD) * Academic and volume discounts available. 2 Year warranty Complete system includes: controller, Teflon TC, TC cord, and adapter (see p. 33) Same power and versatility as the Model 210, but also contains a 100 hour digital timer to turn heating OFF (or ON) at a user specified time. A new safety feature automatically disconnects power from the heater following recovery from a power failure. Contains J-KEM s patented power control computer which provides 0.1 o C regulation of anything. 0.1 o C Regulation & Display NIST traceable Advanced PID algorithm Controller Only Complete System Cat # Price* Cat # Price* 210/Timer-T $ /Timer-T-S $ /Timer-J /Timer-J-S /Timer-K /Timer-K-S NEW!! USB port and Free KEM-Net data logging & control software Thermocouple Temperature Type Range ( o C) T -200 to 250 J 0 to 800 K -50 to 1200 RTD -200 to /Timer-Pt /Timer-Pt-S Specifications: 120vac, 10 amps, 1200 watts. Dim x 6.7 x 6 (HxWxD) * Academic and volume discounts available. 2 Year warranty Complete system includes: controller, Teflon TC, TC cord, and adapter (see p. 33) New in Power Regulation J-KEM s original power control computer is replaced by a next generation microprocessor. The power control computer is J-KEM s patented technology that adjusts power to the heater 2048 times per second resulting in 0.1 o C regulation. At the heart of J-KEM s 200-Series controllers is a new, high speed microprocessor that performs 3 functions: 2. USB Communications PC communications and free KEM-Net software enables remote PC control, GLP/GMP compliant data collection, and multi-temperature ramps built in an Excel-like table. 3. Upgradable Programming Software modules can be uploaded to the processor, at no charge, adding new capabilities to the controller. For example, automatic detection of exothermic reactions. You may not see the exotherm in this plot (and it was a big one), but the microprocessor does. You can t see it because as it occurred, the temperature controller stopped powering the heater to compensate for the heat being generated by the reaction. Page 32 J-KEM Scientific Toll-free: (800) Fax: (314) [email protected]

35 Model 250 The Model 250 has both heating and cooling outlets for maximum versatility. Two heating outlets supply 1800 watts of power for large equipment and heating mantles up to 22 L. The third outlet (1800 watts), normally used for cooling, is programmable to supply power below, above, or at the setpoint. Contains J-KEM s patented power control computer which provides 0.1 o C regulation of anything. 0.1 o C Regulation & Display Model 260/Timer Controller Only Complete System Cat # Price* Cat # Price* 250-T $ T-S $ J J-S K K-S Pt Pt-S Model 250 Accessories NEW!! USB port and Free KEM-Net data logging & control software Thermocouple Temperature Type Range ( o C) T -200 to 250 J 0 to 800 K -50 to 1200 RTD -200 to 400 Coolant valve turns On/Off flow in cooling applications. Cat# 250WV $ Specifications: 120vac, 15 amps, 1800 watts. Dim. 3.5 x 7.75 x 9.25 (HxWxD) * Academic and volume discounts available. 2 Year warranty Complete system includes: controller, Teflon TC, TC cord, and adapter (see p. 33) Designed for processes requiring an extra measure of safety. The Model 260/Timer disconnects outlet power if the process temperature exceeds the setpoint by a user specified amount, or following recovery from a power failure. Power remains off until the controller is manually reset. Over temperature is signalled 0.1 o C Regulation & Display NIST traceable Advanced PID algorithm by both an indicator lamp and an audible alarm. Contains a 100 hour digital timer to turn heating OFF (or ON) when the time expires. The Model 260 has two power outlets (1800 watts) for large equipment or heating mantles up to 22 L. Contains J-KEM s patented power control computer which provides 0.1 o C regulation of anything. 230VAC, CE approved Model 360 available NIST traceable Advanced PID algorithm Controller Only Complete System Cat # Price* Cat # Price* 260/Timer-T $ /Timer-T-S $ /Timer-J /Timer-J-S /Timer-K /Timer-K-S /Timer-Pt /Timer-Pt-S NEW!! USB port and Free KEM-Net data logging & control software Thermocouple Temperature Type Range ( o C) T -200 to 250 J 0 to 800 K -50 to 1200 RTD -200 to 400 Specifications: 120vac, 15 amps, 1800 watts. Dim. 3.5 x 7.75 x 9.25 (HxWxD) * Academic and volume discounts available. 2 Year warranty Complete system includes: controller, Teflon TC, TC cord, and adapter (see p. 33) The Complete System 1. Types T & K Temperature Controller have the best corrosion resistance 2. Thermocouple Teflon Probe Extension Cord Teflon Coated Thermocouple Adapter (14/20 joint) J-KEM Scientific Toll-free: (800) Fax: (314) [email protected] Page 33

36 Gemini Multi-Channel Controllers Features two temperature controllers in a single cabinet to regulate two independent reactions. The Gemini is among J-KEM s most versatile controllers featuring high power outlets and a 100 hour digital timer (on channel 1) to turn heating OFF (or ON) at a user entered time. Features include: over-temperature protection circuits with audible alarms, dual temperature displays, selectable operating modes, double fused, and 100% solid state design. Contains J-KEM s patented power control computer which provides 0.1 o C regulation of anything. 0.1 o C Regulation & Display Apollo Gemini controls TWO independent reactions! 230VAC, CE approved Gemini-CE available Controller Only Complete System Cat # Price* Cat # Price* Gemini-T $ Gemini-T-S $ Gemini-J Gemini-J-S Gemini-K Gemini-K-S NEW!! USB port and Free KEM-Net data logging & control software Thermocouple Temperature Type Range ( o C) T -200 to 250 J 0 to 800 K -50 to 1200 RTD -200 to 400 Gemini-Pt Gemini-Pt-S Specifications: 120vac, 15 amps, 1800 watts total, 1200 watts maximum per channel. Dim. 3.5 x 7.75 x 9.25 (HxWxD) * Academic and volume discounts available. 2 Year warranty Includes: controller, plus two each of: Teflon TC, TC cord, and adapter (see p. 33) Features two independent temperature controllers in a single cabinet to regulate two reactions at the same time. Each temperature controller channel has a high power outlet and a 100 hour digital timer to turn heating OFF (or ON) at a user set time. Features include: over-temperature protection circuits, dual temperature displays, selectable operating modes, double fused, and 100% solid state design. Contains J-KEM s patented power control computer which provides 0.1 o C regulation of anything. Controls TWO independent reactions! 0.1 o C Regulation & Display The Quad Controller Only Complete System Cat # Price* Cat # Price* Apollo-T $ Apollo-T-S $ Apollo-J Apollo-J-S Apollo-K Apollo-K-S NEW!! USB port and Free KEM-Net data logging & control software Thermocouple Temperature Type Range ( o C) T -200 to 250 J 0 to 800 K -50 to 1200 RTD -200 to 400 Apollo-Pt Apollo-Pt-S Specifications: 120vac, 15 amps, 1800 watts total, 1200 watts maximum per channel. Dim. 4 x 8.2 x 9 (HxWxD) * Academic and volume discounts available. 2 Year warranty Includes: controller, plus two each of: Teflon TC, TC cord, and adapter (see p. 33) Because we ve never met a chemist with too much bench space, the Quad packs four independent temperature controllers into a single compact unit. Each of the four controller channels has 1200 watts of power, an independent display, and an over-temperature protection circuit. Contains J-KEM s patented power control computer which provides 0.1 o C regulation of anything. 0.1 o C Regulation and Display NIST traceable Advanced PID algorithm NIST traceable Advanced PID algorithm Think of the Quad as a Model 210 on steroids NIST traceable Advanced PID algorithm Controller Only Complete System Cat # Price* Cat # Price* Quad-T $ Quad-T-S $ Quad-J Quad-J-S Quad-K Quad-K-S NEW!! USB port and Free KEM-Net data logging & control software Thermocouple Temperature Type Range ( o C) T -200 to 250 J 0 to 800 K -50 to 1200 RTD -200 to 400 Quad-Pt Quad-Pt-S Specifications: 120vac, 15 amps, 1800 watts total, 1200 watts maximum per channel. Dim x 7 x 7.5 (HxWxD) * Academic and volume discounts available. 2 Year warranty Includes: controller, plus four each of: Teflon TC, TC cord, and adapter (see p. 33) Page 34 J-KEM Scientific Toll-free: (800) Fax: (314) [email protected]

37 Model 270 High Safety Controllers Designed for processes requiring uncompromised safety. The only temperature controller available with a built-in, independent, backup controller to guard against heating accidents from equipment failure. The desired temperature is entered into the main temperature controller which regulates heating, and then a high temperature cut-off is entered into the backup limit controller. If the reaction reaches the high temperature limit or a thermocouple breaks, power is turned off to the heater until the controller is manually reset. Both meters independently monitor the reaction temperature. In the event that one meter fails, the other takes over to prevent a heating accident. J-KEM s design provides independent, 100% redundant control. Contains J-KEM s patented power control computer which provides 0.1 o C regulation of anything. * * 0.1 o C Regulation & Display * * Model HCC The line of HCC controllers are designed to power large scale equipment with volumes up to 100 L. Built with the same uncompromising commitment to safety as our Model 270, the HCC is available in 3 models for 120 and 230 volt operations. In addition to the features of the Model 270, these high power controllers incorporate a 100 hour timer to turn heating OFF (or ON) at a user set time. The HCC is readily customized to meet unique research or additional safety needs. Call for details. Contains J-KEM s patented power control computer which provides 0.1 o C regulation of anything. Controller Only Complete System Cat # Price* Cat # Price* 270-T $ T-S $ J J-S K K-S Specifications: 120vac, 15 amps, 1800 watts. Dim. 3.4 x 7.75 x 9.25 (HxWxD) NIST traceable Advanced PID algorithm NEW!! USB port and Free KEM-Net data logging & control software Thermocouple Temperature Type Range ( o C) T -200 to 250 J 0 to 800 K -50 to 1200 Requires a dual element thermocouple (see below) * Academic and volume discounts available. 2 Year warranty Includes: controller, dual element Teflon TC, TC cord, and adapter (see p. 33) High Power Controllers NEW!! Three Models of HCC to choose from HCC 130 Voltage: V Power: 30 amps; 3600 watts Description Cat # Price Model HCC-130 controller only. HCC-130-T $ Requires a dual element thermocouple and HCC-130-J thermocouple extension cord (see below). HCC-130-K HCC 215 Voltage: V Power: 15 amps; 3600 watts Model HCC-215 controller only. HCC-215-T $ Requires a dual element thermocouple and HCC-215-J thermocouple extension cord (see below). HCC-215-K HCC 230 Voltage: V Power: 30 amps; 7200 watts Model HCC-215 controller only. Requires a dual element thermocouple and thermocouple extension cord (see below). Dimensions: 5.5 x 12 x 12.5 (HxWxD) USB port and Free KEM-NEt data logging & control software Temperature range of all HCC controllers Thermocouples for Model 270 and HCC Controllers HCC-230-T $ HCC-230-J HCC-230-K T J K -200 to 250 o C 0 to 800 o C -50 to 1200 o C Probes listed are Teflon coated. Stainless steel and glass probes are also available. Dual element thermocouples contain two independent thermocouples in a single probe. Model 270 and HCC controllers require either 1 dual-element or 2 single-element thermocouples. Tefl on Coated Dual Element Thermocouples Dual Element Thermocouple Extension Cords Probe Thermocouple Diameter (in.) Length (in.) Cat # Price Length Cat # Price 1/8 12 TC270-(*)-18T12 $ ft. EXT (*) $ /4 12 TC270-(*)-14T ft. EXT (*) /4 24 TC270-(*)-14T /4 36 TC270-(*)-14T Probes of any length are available. * Specify thermocouple type T, J, or K * Specify thermocouple type T, J, or K J-KEM Scientific Toll-free: (800) Fax: (314) [email protected] Page 35

38 Model 410 Model 150 Oil Bath Controller Variable Voltage Output The Model 410 is designed for heaters that cannot be operated at 120 Vac, such as some styles of oil baths. The maximum output voltage of the Model 410 is selected using the Power Output knob on the front of the controller. Selectable output voltage limits provide precise power and temperature control while protecting low voltage heaters. Contains J-KEM s patented power control computer which provides 0.1 o C regulation of anything. 0.1 o C Regulation & Display Output Voltages of: 10, 20, 40, 60, 120 Vac Controller Only Complete System Cat # Price* Cat # Price* 410-T $ T-PKG $ J J-PKG K K-PKG Economy Temperature Controllers An ideal controller for applications that don t require the precise regulation of J-KEM s 200-Series controllers. This compact unit packs 1200 watts of power, sufficient for 5 L heating mantles, many ovens, and other devices. Built with J-KEM s state-of-the-art PID process controller, but does not contain J-KEM s power control computer. See comparison below. NIST traceable Advanced PID algorithm Ramp-to-setpoint feature standard Model 150/Timer NIST traceable Advanced PID algorithm Ramp-to-setpoint feature standard What s the difference between J-KEM s 200-Series controller and the 150-Series? Controller Only Complete System Cat # Price* Cat # Price* 150-T $ T-S $ J J-S K K-S NEW!! USB port and Free KEM-Net data logging & control software Thermocouple Temperature Type Range ( o C) T -200 to 250 J 0 to 800 K -50 to 1200 RTD -200 to Pt Pt-PKG Specifications: 120vac, 10 amps, 1200 watts. Dim x 5.25 x 7.25 (HxWxD) * Academic and volume discounts available. 2 Year warranty Complete system includes: controller, stainless steel TC, and TC cord (see p. 33) Thermocouple Temperature Type Range ( o C) T -200 to 250 J 0 to 800 K -50 to 1200 Model 150 Options Cat # Price RS232 Serial Port for PC control and data logging. add -RS232 $ High Power Output Vac add -HC Specifications: 120vac, 10 amps, 1200 watts. Dim. 2.5 x 3.75 x 5.4 (HxWxD) * Academic and volume discounts available. 2 Year warranty Complete system includes: controller, Teflon TC, TC cord, and adapter (see p. 33) Same power and versatility as the Model 150, but also contains a 100 hour digital timer to turn heating OFF (or ON) at a user set time. See comparison to the 200-Series at bottom of page. Controller Only Complete System Cat # Price* Cat # Price* 150/Timer-T $ /Timer-T-S $ /Timer-J /Timer-J-S /Timer-K /Timer-K-S Thermocouple Temperature Type Range ( o C) T -200 to 250 J 0 to 800 K -50 to 1200 Model 150 Options Cat # Price RS232 Serial Port for PC control and data logging. add -RS232 $ High Power Output Vac add -HC Specifications: 120vac, 10 amps, 1200 watts. Dim. 2.5 x 4.75 x 5.5 (HxWxD) * Academic and volume discounts available. 2 Year warranty Complete system includes: controller, Teflon TC, TC cord, and adapter (see p. 33) Feature 200-Series 150-Series Temperature regulation 0.1 o C 1 o C Smallest regulated volume 0.01 ml 250 ml USB port & software Free Optional J-KEM s 200-Series controllers have our patented power control computer with technology that provides 0.1 o C regulation of any instrument or volume as small as 100 µl. The 150-Series combines a state-of-the-art PID process controller with solid state circuitry to provide unparalleled performance in its price range. The 150-series is ideal for equipment such as reaction blocks, ovens, or heating mantles 500 ml or larger. NIST traceable Advanced PID algorithm Page 36 J-KEM Scientific Toll-free: (800) Fax: (314) [email protected]

39 Serial Communications, PC Control, Data Logging & The J-KEM Advantage The J-KEM Advantage Research grade temperature (200-Series) and vacuum regulators contain two next-generation FLASH programmable microprocessors. PC Control with Free KEM-Net Software Processor 1 The Power Control Computer The patented power control computer is the heart of every J-KEM temperature controller. The computer adjusts power to the heater 2048 times per second resulting in 0.1 o C regulation of any reaction and virtually eliminates overshoot of the entered setpoint on initial warming. Processor 2 USB Communications The communications processor, new in 2009, implements PC control, data logging, and our new web based FLASH Modules. FLASH Modules are programs that can be downloaded from J-KEM s web site to your controller at no charge. An example of a FLASH module is the Exo/ Endo module that automatically quantifies, then alerts the user when an exothermic reaction is detected. KEM-Net software is included with all USB enabled controllers. Features: Run 16-step temperature and vacuum ramps Easy setup using an Excel-like table input Enter setpoints and controller parameters remotely Real-time graphical display and data logging to Excel Encrypted data file is tamper-proof, meeting GLP and GMP requirements alerts of over- & under-temperature alarms PC Control, serial communications, networking, and data logging explained... J-KEM supports three serial communications standards: USB, RS-232, and RS-485. Each has advantages and limitations. J-KEM USB This is the standard port on 200-Series temperature controllers and the Digital Vacuum Regulator. The advantage of USB is that it s present on all PCs and supports connecting multiple controllers to a single PC. The only limitation of USB is that cable lengths cannot be longer than 15 feet without using a USB extender (offered below). Controllers connect to the PC s USB ports or a USB hub. RS-232 A hardware RS-232 port is available, but usually not needed. J-KEM s USB port includes a virtual RS-232 port driver that operates with software utilizing RS-232 communications. RS-485 has the unique advantage that cable lengths between the instrument and PC can be as long as 4000 feet. For lab arrangements that require long cable runs, RS-485 is a valuable alternative. Contact J-KEM for ordering assistance. J-KEM s KEM-Comm software is required for RS-485 communications. USB to RS485 converter Serial Communication Options and Accessories Description Cat # Price USB Extender, 50-Foot. Amplifi er extends USB communications to 50 feet. Includes extender and 50 cable. USBC-50 $94.00 USB Extender, 100-Foot. Amplifi er extends USB communications to 100 feet. Includes extender and 100 cable. USBC USB Extender, 150-Foot. Amplifi er extends USB communications to 150 feet. Includes extender and 150 cable. USBC USB 4-Port Hub. Used to connect multiple controllers to a single PC USB port USBH RS-232 Port. Physical RS-232 port substituted for the USB port. Add as a suffix to any controller, Ex: 210-T-RS232 RS RS-485 Port. Physical RS-485 port substituted for the USB port. Add as a suffix to any controller, Ex: 210-T-RS485 RS USB to RS-485 Converter. Converts a PC USB port to RS-485 with the proper connector style for J-KEM controllers USB KEM-Comms Software. PC control and data logging software for RS-232 and RS-485 ports. Not needed for USB KEM-Comm J-KEM Scientific Toll-free: (800) Fax: (314) [email protected] Page 37

40 Thermocouples & Accessories NEW! Glass over-coated thermocouples Note: To read temperatures accurately, the type of the thermocouple must match the controller s type. On a new controller, the type is the letter immediately following the model number: K - S On an existing controller, the thermocouple type is indicated by the color of the thermocouple receptacle on the front. If the receptacle is: BLUE YELLOW - - BLACK WHITE you must order a type T thermocouple you must order a type K thermocouple you must order a type J thermocouple you must order a type Pt/100 sensor Thermocouple Probe Outer Thermocouple Probe Length Type Diameter (in.) Overcoating 1 (inches) T ($0) 1/16 ($33.00) Uncoated ($0) 6 ($0) J ($0) 1/8 ($34.00) Teflon 2 ($30.00) 12 ($0) K ($0) 1/4 ($38.00) Glass 3 ($40.00) 18 ($11) Pt/100 ($60.00) 24 ($15) 36 ($28) Probes are color coded 1- All sensors are housed in 304 stainless steel sheaths. 2- PFA coating over SS probe. 3- Borosilicate glass. Available as 1/4 probe only. Probes of any length are available To determine the Catalog Number of a probe: 1. Enter the thermocouple type (T, J, K, Pt/100) 2. Enter the outer diameter of the probe (1/16, 1/8, or 1,4) 3. Enter the probe over coating (U= Uncoated, T= Teflon, G= Glass) 4. Enter the length of the probe in inches Thermocouple Calibration To determine the Price of a probe: Total the dollar value associated with each selection made from all four columns Examples: T-1/8-U Price: $ = $34.00 K-1/4-G Price: $ = $89.00 J-KEM offers thermocouple calibration in standard and extended temperature ranges. Calibrated at three points in the stated range with NIST traceable standards and supplied with a certificate of calibration. Additional calibration points available on request. Description # of Points Temp. Range Cat # Price Thermocouple calibration, standard temperature range 3 0 o C to 150 o C STCC $ Additional calibration points in Thermocouple calibration, extended temperature range 3 0 o C to 300 o C ETCC stated range are $35.00 each. Thermocouple calibration, low temperature range o C to 300 o C LTCC Coiled Cord Straight Cord Thermocouple Extension Cords Retractable coiled cord saves space in crowded hoods. 26 gauge multi strand wire with PVC insulation. Teflon insulated wire for superior chemical resistance. 24 gauge single stranded wire. Coiled Thermocouple Cords (see type and connectors below) Catalog Number Extended Length Price CC-10-(type)-(connector) 10 feet $26.00 CC-20-(type)-(connector) 20 feet Straight Thermocouple Cords (see type and connectors below) EXT-10-(type)-(connector) 10 feet $17.00 EXT-20-(type)-(connector) 20 feet Select a connector type Type Select type: T, J, K, or Pt/100 The cord, controller, and thermocouple must all be of the same type. Specify: T for a blue plug J for a black plug K for a yellow plug Pt/100 for a white plug Ordering Examples: CC-10-T-SMP EXT-20-K-OST Select a connector style Connector Select plug style: SMP or OST Style SMP Fits all controllers Style OST Fits 250, 260,270, HCC Page 38 J-KEM Scientific Toll-free: (800) Fax: (314) [email protected]

41 Thin Wire Thermocouples Flexible yet rugged thermocouples measure difficult to reach spots such as inside heating mantles, ovens, or around curved surfaces. Also useful to measure volumes as small as 100 µl. Thin wire thermocouples adhere to equipment to measure surface temperatures of hot plates, HPLC columns, photolysis or other reactors. Teflon Coated Thin wire thermocouple (30 gauge; 36 long) completely sealed in Teflon for submersion in solution. Excellent for use with small volumes (<100 µl). Inserts through rubber septum for airtight seal. Extremely flexible. Exposed Junction Teflon wire (30 gauge; 72 long) exposed junction is ideal for rapid temperature measurement of solids, air, or heating mantles. Not suitable for continuous liquid contact. Needle Tip Thermocouples Teflon Coated Thin Wire Thermocouple Description Cat # Price Type T Teflon embedded TEF-30-T $89.20 Type K Teflon embedded TEF-30-K Exposed Junction Thin Wire Thermocouple Type T exposed junction TWT-T Type K exposed junction TWT-K Type J exposed junction TWT-J Longer lengths and other diameters are available on request. Hypodermic needle thermocouples (17 gauge) are ideal to measure and control the temperature of small volumes and inert reactions. Temperature measuring end of the thermocouple is at the tip, so only the first 2 mm of the probe must have liquid contact for accurate temperature measurement. Forms an air tight seal when inserted through a septum. Needles are sealed on the end for liquid tight applications. Available in 3.5 and 7 lengths. These stainless steel needles are also available with Teflon coating. Each comes with 72 inches of attached Teflon extension wire. Teflon coated needle thermocouples! NEW Thermocouple Needle Teflon Coated Needles Uncoated Needles Type Length Catalog # Price Catalog # Price T 3.5 HN-3.5-T-TEF $93.00 HN-3.5-T $ HN-7-T-TEF HN-7-T K 3.5 HN-3.5-K-TEF HN-3.5-K HN-7-K-TEF HN-7-K J 3.5 HN-3.5-J-TEF HN-3.5-J HN-7-J-TEF HN-7-J Reaction Block Thermocouple Armored cable thermocouple has a spring loaded bayonet style connector for rapid and secure connection to reaction blocks. Flexible cable is designed for the constant shaking of reaction blocks. Thermocouple Adapters Adapters enable plugging thermocouples with an SMP (small flat pins) or OST (larger round pins) plug into controllers with the opposite receptacle style. Thermocouple Type Cat # Price Type T RBTC-T $64.00 Type K RBTC-K Type J RBTC-J Thermocouple OST Male SMP Male Type SMP Female OST Female Price Type T ADP-T ADA-T $9.75 Type K ADP-K ADA-K 9.75 Type J ADP-J ADA-J 9.75 Teflon Probe Adapters Teflon probe adapters form air tight seals between thermocouple probes and standard taper joints. Not suitable for high vacuums Thermocouple Adapters Probe Joint Diameter Size Cat # Price 1/16 10/ $ /16 14/ /16 24/ /16 29/ /8 10/ /8 14/ /8 19/ /8 24/ /8 29/ /4 14/ /4 24/ /4 29/ Replacement O-Rings for Thermocouple Probes Probe Viton (Pk of 12) Kalrez (Each) TEV* (Each) Dia. Cat # Price Cat # Price Cat # Price 1/ R $9.00 1/8 1810R RK $ /4 1410R RK RT $21.00 Replacement Adapter External O-Rings Joint Viton (Pk of 12) Kalrez (Each) TEV* (Each) Size Cat # Price Cat # Price Cat # Price 14/ E $ EK $ ET $ / E EK ET / E EK ET * Viton O-ring encapsulated in Teflon over coating J-KEM Scientific Toll-free: (800) Fax: (314) [email protected] Page 39

42 Heating Mantles Heating mantles are the safest method of laboratory heating because they avoid the burn hazards associated with other styles of heaters. Heating mantles uniformly heat glassware and remain cool to the touch, even at internal temperatures > 300 o C. Series-OS heating mantles can be placed directly on top of magnetic stirrers providing vigorous mixing using a stirring bar. Research Heaters Heating Mantle 120 Vac Mantles 230 Vac Mantles 120 Vac Mantles 230 Vac Mantles Size (ml) Catalog # Price Catalog # Price Catalog # Price Catalog # Price Wattage 5 OS-5 $ Not available - Not available - Not available OS Not available - Not available - Not available OS Not available - Not available - Not available OS Not available - TM-50 $ Not available OS Not available - TM TM-100/230 $ OS OS-250/230 $ TM TM-250/ OS OS-500/ TM TM-500/ ,000 OS OS-1000/ TM TM-1000/ ,000 OS OS-2000/ TM TM-2000/ ,000 OS OS-3000/ TM TM-3000/ ,000 OS OS-5000/ TM TM-5000/ ,000 OS OS-12000/ TM TM-12000/ @650 22,000 OS OS-22000/ TM TM-22000/ @770 50,000 Not available - Not available - TM TM-50000/ @ ,000 Not available - Not available - Not available - TM-72000/ @2000 Instatherm Oil Baths The intelligent design of the Instatherm oil bath, from Ace Glass, includes features that make it the safest and most reliable oil bath for laboratory use. The metal alloy heating element is fused directly to the surface of the glass bath and then covered with a tough silicone rubber layer and a glass insulation layer which serves as both a thermal barrier and protects against physical shock. The bottom of the Instatherm is not heated so the bath can be placed on magnetic stirrers. The Instatherm bath can be operated up to 250 o C. Includes power cord. Series-TM heating mantles have a self-supporting aluminum shell. The TM mantle is stable on bench tops, and with extra insulation, the exterior remains cool to touch. Maximum internal temperature of 450 o C. Not suitable for magnetic stirrers. * Accommodates a variety of vessel sizes and shapes * Suitable for magnetic stirrers Glass Electrical connections Fused-to-glass Conductive heating film Integral outer Insulation For maximum versatility, J-KEM recommends the INS-150 and INS-190 oil baths. These baths can be used with any 200-Series temperature controller, which can also be used with any heating mantle (above). Thus, the same controller can be used with either heating mantles or oil baths. Bath Size Max. Applied Voltage (Dia. x Hght.) Cap., ml (Volts/Amps) Cat # Price Temperature Controller Compatibility 70 x 50 mm 160 ml 20V/5A INS-70 $ Low voltage bath compatible with Model 410 (p. 36) and Trinity controller (p. 29) 100 x 50 mm 340 ml 40V/6A INS Low voltage bath compatible with Model 410 (p. 36) and Trinity controller (p. 29) 125 x 65 mm 700 ml 40V/8A INS Low voltage bath compatible with Model 410 (p. 36) and Trinity controller (p. 29) 150 x 75 mm 1200 ml 120V/5A INS Can be used with any J-KEM Digital Controller. 190 x 100 mm 2600 ml 120V/10A INS Can be used with any J-KEM Digital Controller INS-PC Replacement power cord for Instatherm oil bath Page 40 J-KEM Scientific Toll-free: (800) Fax: (314) [email protected]

43 The Road We re On (together) 1988 Incorporated as J-KEM Electronics. Offering one product, the Model 260 temperature controller, we fi nish our fi rst year with sales of $ Flush with cash from its fi rst year sales, J-KEM doubles its product line and begins offering the Model 210. Attended the Fall ACS meeting, exhibiting all four of the controllers we owned, then spent sleepless nights worrying how we d fi ll orders if they came in J-KEM s fi rst major customer was Dr. James Zeller of Parke Davis. J-KEM expands its manufacturing area 400% by moving from just the corner to occupy the entire basement (sorry girls about your play house) First international sale. Model 210 to Italy Moved to our first commercial building. Hired our fi rst full time employee (Li, above). Built the fi rst power control computer (8 bits, 4 MHz!!) Incorporated as J-KEM Scientific Purchased our fi rst building, a 1930 s fi re house First years sales >$1,000, First robot sold to Dr. Glass of Zenica Emphasis in lab automation, parallel reactors, and robotics Staying abreast with advances in technology: Third generation power control computer Second generation Syringe Pumps Two new robotic designs Custom lab automation instruments and software J-KEM Scientific s employees gathered around the fire pole of our first facility, the fire house. J-KEM appreciates the relationship we ve had with all of our customers. It s more than just the obvious fact that without you, J-KEM would not be in business. We appreciate the friendships and the ideas we ve received from world class scientists, that without, many of our best products wouldn t exist. Don Korte gave us the idea for the miniature overhead stirrer, Martyn Fordham, the Personal Reaction Station, Dr. Bruce Hamper the Solid Phase Synthesis Regulator, and the unknown chemist from Abbott who came to our booth at the ACS show to say I don t need a temperature controller, I need a vacuum regulator that works. This resulted in our Digital Vacuum Regulator. 20 Years of Innovation The first temperature controller made by J-KEM, sold to Dr. Kurt Moedritzer of Monsanto (Dr. Moedritzer also purchased controller #2. Our first loyal customer!!) 40 MHz microprocessor enables * Exo & Endotherm analysis * USB communications * Enhanced safety Pictured are the original (left) and new (right) Model 210-Timer circuit boards In 2008, J-KEM completed the redesign and implementation of the 3rd generation of its power control computer. The new design uses a FLASH programmable microprocessor that can be updated with new controller features from J-KEM s web site.

44 KEM Instruments for Science from Scientists Scientific J-KEM Scientific, Inc Olive Blvd. St. Louis, MO USA Phone (314) (800) Fax (314) Web