1 Four Robotic Platforms to Choose From. 2 Custom Solutions. 3 Do-It-Yourself Robotics

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1 Custom Laboratory Robotics Eclipse Workstation With four robot styles and multiple software options, J-KEM is uniquely positioned to offer custom robotic solutions for virtually any lab automation need. J-KEM s technology makes lab automation as Simple as 1, 2, 3. Key Features: Fast Positional accuracy Affordable Multiple Z-probes Phoenix Workstation 1 Four Robotic Platforms to Choose From With four different robotic platforms, J-KEM can select the one that most efficiently automates your unique application. Each platform has its own set of advantages including speed, positional accuracy, power, and price that make it the preferred system for different applications. Key Features: Large deck size Multiple Z-probes Generates > 100 lb. of force in the Z- direction. Voyager Workstation 2 Custom Solutions J-KEM offers complete hardware and software solutions for almost any lab automation task. Every workstation is customized with the features and software needed to run your specific application. Workstations for: Weighing Dissolution Synthesis Sorting Crystallization Cherry picking SPE SPS Spectroscopy Key Features: Fast Optimized for microvial weighing and cherry picking applications Endeavour Workstation Key Features: Fast Positional accuracy Most affordable workstation available 3 Do-It-Yourself Robotics New in 2009 J-KEM offers each of its robotic systems with custom programming, professional installation, and user training. For most researchers, this is the service they both need and expect. For those research teams who prefer to do it themselves, J-KEM now offers each of its robotic systems as a fully configured and tested workstation, but with no pre-installed software. With complete systems starting under $6,000, this is a highly affordable way to introduce robotics to your workflow. Software options are available to support your custom development. Page 2 J-KEM Scientific Toll-free: (800) Fax: (314) info@jkem.com

2 Eclipse Robotic Workstations The Eclipse workstation uses modular X- and Y-axis rails combined with a wide selection of automated tools such as grippers, multi-position needles, and custom probes. The open design of the Eclipse provides easy access to the entire workstation deck. Value: From $20,000 Affordability: The affordable price of the Eclipse (starting under $20,000) creates new opportunities for lab automation. For example, a weighing station with bar code scanner and 0.01 mg resolution balance costs about $28,000. Features: Speed: 400 mm/sec Positional Accuracy: ±0.02mm Z-Axis Force: 10 pounds Examples of Eclipse Workstations Test Tube Weighing Station Bar code scanner Excel output Analytical balance Plate Washer with Heated Reaction Station See the Eclipse in action at: Solid Phase Extraction Station Multi-step synthesis program run in micro titer plate cells Plate gripper Temperature controlled reactor 24 Columns developed in parallel Controls flow rate in all columns Solvent level in each column is optically monitored to stop solvent flow when the solvent front reaches the top of the packing. Derivatization Station Spectroscopy Robot Automated spectroscopic analysis of 200 samples Reagent addition to septum vials Heated reactor with mixing Reaction mixture sampled at user set times to GC vials J-KEM Scientific Toll-free: (800) Fax: (314) info@jkem.com Page 3

3 Advantages of J-KEM Robotics Custom Design While others start from an existing design, then try to make your application fit their instrument, every J-KEM workstation is designed from scratch to implement your automation task efficiently and with an eye towards future expandability. J-KEM s experience in lab automation, including temperature control, reactor design, fluid delivery, solid and solution phase synthesis is invaluable when optimizing the design of custom robotics. Polymer Compounding Robot Modules: 4-Temperaure zone reaction block, balance, bar code reader, heated & cooled reagent block, cooled 4-position sonicator, precision syringe pump with 16 reagent ports, 6-zone temperature controller, and needle wash station. You Own the Solution J-KEM believes that you should not only own the instrument, but you should own the technology that created the instrument. That s why we are the only company that releases the original source code with every robot. This gives you the power to change every aspect of the robot s operation as your automation needs change. Custom Software Custom software is written for every workstation to provide an intuitive user interface. The procedure s setup, the way data is read into and out of the program, and the exact sequence of program steps are all customized to make the operation of your robot both efficient and user friendly. Personal Service J-KEM is committed to personal service, offering any support that s needed to assure the successful integration and productivity of our automation solutions. With one phone call, you can talk to the engineer who designed your robot, the engineer who installed it, and the software engineer who wrote the program. Value J-KEM s custom robotics are often half the price of other companies one-size-fits-all alternative. While many of the modules on a workstation are standard J-KEM products, we also use the best available instruments like balances, bar code readers, and pumps to assemble the final workstation in the most affordable and efficient manner. It s not really enough to own the code if it s not easy to use. Written in VB.Net, the robotic software contains intuitive, high level functions that make understanding or modifying your code easy. Consider the example to the right that weighs every vial in a 96 vial rack. For Vial = 1 to 96 Rack.MoveToCell(XY, Vial) Gripper.PickUpVial() Balance.Tare() Balance.MoveToCell(XY, 1) MyWeight = Balance.Weight() PutVialBack(Vial) Next Why is it important to own the original source code? Without the source code, you re stuck with the robot you have rather than the robot you need as your automation needs change. For example, suppose the robot s original task was weighing and dissolving samples to specific concentrations, but now you need it to add reagents to 4 ml septum vials in a temperature controlled reactor with mixing. In most cases you d need to purchase a new robot. Even for small changes, if you don t own the original source code, then you re 100% dependent on the company who does. J-KEM offers ongoing software support for all of our customers. But still, to own the tools that place you in control of your own workstation is invaluable. Page 4 J-KEM Scientific Toll-free: (800) Fax: (314) info@jkem.com

4 Phoenix Robotic Workstations Phoenix workstations have three distinctive characteristics: 1. Large deck size that allows access to multiple racks and modules such as shakers, balances, and filter stations. 2. Multiple Z-probe tools. This robot has simultaneous access to three 2.5 ml disposable tip probes, three 200 µl disposable tip probes, a septum penetrating needle, a vial gripper, three stainless steel cannula, and a pressure plate to filter samples using positive pressure. Sample Dilution and Filtration Station 3. The Z-axis can develop over 100 pounds or force, enough to penetrate any septum or seal any reactor. Enzyme Specific Activity Workstation Examples of Phoenix Workstations Cherry Picking and Sample Reformatting Workstation Robot Modules Deck fits five Gilson racks of any style Disposable pipette tip probe Syringe pump with 8-port selectable valve Workstation Procedure In this application, samples arrive in a variety of formats, including 4 ml, 8 ml, and 20 ml vials, three different size test tubes, 24, 48, and 96 well titer plates. This workstation reformats samples from the various tubes to a single 96 well plate. From the master plate, a cherry picked plate is made based on the input from an Excel table. Workstation Procedure Samples are transferred, by weight, to 400 ml beakers where they are diluted 1200-fold. After mixing, diluted samples are dispensed to sample vials for analysis. Robot Modules Analytical balance 60-position high power magnetic stirrer Syringe pump with 8-port selectable valve Gripper for vial transport Cannula for large volume dispenses (> 100 ml) and analytical needle for microliter dispenses Sample Dissolution and Daughter Plate Preparation Robot Modules Syringe pump with 8-port selectable valve Analytical balance Bar code station Gripper for vial transport Septum penetrating needle Workstation Procedure Dissolves solid samples to a standard concentration, then adds additional liquid reagents. After mixing, transfers aliquots to HPLC vials with septum caps and to a titer plate cell. The identity of all vials are tracked by bar code, and the volume of reagents dispensed is verified by weight. J-KEM Scientific Toll-free: (800) Fax: (314) info@jkem.com Page 5

5 Voyager Robotic Workstations The Voyager workstation is optimized for weighing and sorting glass or plastic vials in 96 position tube racks. The Voyager integrates a Mettler balance with 10 µg resolution, an Opticon 2D bar code scanner, and high speed X, Y, & Z drives. Combining world-class hardware with intuitive software makes the Voyager the finest workstation for tube handling available. See the Voyager in action at: Intuitive Software Voyager s software includes applications for weighing, scanning, sorting, and cherry picking tubes. Support for data input and output from a variety of file formats, including Excel,.CVS, and.txt files is standard. Custom input/output file formats to access corporate data bases or to interface with other laboratory instruments is available. The Z-arm automatically adjusts to different tube heights and even supports different tube sizes in the same run. Various liquid dispensing options are available for microliter to milliliter aspirate and dispense operations. Features: Weighs up to 220 vials per hour g (10 µg) balance 2D bar code scanner decodes 2D and all 1D bar code symbologies Gripper customized to individual vials Reads and writes to any data base Liquid dispensing/transfer options Applications: Tube identification and weighing Tube sorting and re-arraying Cherry picking Voyager-12 Workstation The Voyager-12 has positions for 12 tube racks and 2 additional receiving racks for re-arraying or cherry picking. Includes a Mettler balance with 10 µg resolution and 2D bar code scanner. Specifications: Dimensions: 30 x 26 x 20 (DxWxH) Speed, X & Y-axis: 120mm/sec Positional accuracy: 0.02mm Tube Heights: 0.5 to 2.5 inches Communications: Requires 1 USB port Power: 120 watts Voyager-24 Workstation The Voyager-24 has positions for 24 tube racks plus 2 additional receiving racks for re-arraying or cherry picking. Includes a Mettler balance with 10 µg resolution and 2D bar code scanner. Specifications: Dimensions: 30 x 38 x 20 (DxWxH) Speed, X & Y-axis: 120mm/sec Positional accuracy: 0.02mm Tube Heights: 0.5 to 2.5 inches Communications: Requires 1 USB port Power: 120 watts The Voyager workstation can be equipped with custom grippers to transport a variety of tube styles, including centrifuge tubes. $19,950 $21,600 Microtube above balance pod Optional Features Stainless steel or Teflon cannula for the addition of liquid reagents Spectroscopic probes Mixing Heated reaction stations Custom user modules Page 6 J-KEM Scientific Toll-free: (800) Fax: (314) info@jkem.com

6 Endeavour Robotic Workstations Starting under $6000 The Endeavour is J-KEM s most compact and affordable system, an ideal choice when either bench space or budgets are limited. The Endeavour is also a great starting point for researchers who want to develop their own automation instruments. In one compact enclosure, the Endeavour includes all the needed electronics, drivers, and power supplies. Combined with J-KEM s software, the Endeavour can be programmed to run complex motion control programs, even 3-axis arc interpolations, in a matter of hours. The Endeavour is servo motor controlled to provide rapid and precise motions with positional accuracies of 0.02mm. Software Support Two software packages are available for the Endeavour robot. Endeavour.dll exposes high level functions, like those shown in the example below, that handle all of the low-level tasks associated with serial communications and motor control. Endeavour.dll exposes functions for every motion parameter including acceleration, positioning, homing an axis, and I/O support. Endeavour.dll is included at no charge with all orders. J-KEM also offers its AutoKem software written in Microsoft s Visual Studio 2008.Net in the Visual Basic language. AutoKem provides the user with a feature rich application having classes for racks, balances, syringe pumps, bar code readers, and many other instruments so they can be added to an application with only a few lines of code. The original source code for AutoKem is provided to further support Examples of Robot Commands from Endeavour.dll custom programming. Command Description HOME(X) Home the X axis. MOVE(Y,127.40) Move on the Y axis to position mm. J-KEM manufactures custom modules for the Z plate of the Endeavour robot. Grippers Needles Syringes Disposable tips Two Axis Endeavour MOVE(X,100.0, Y,235.0, Z,25.5) Perform a simultaneous 3-axis move to the specified coordinates. OUTPUT(12,ON) Turn user I/O output 12 on. INPUT(7) Returns 0 if the input is low, 1 if high. Endeavour Catalog # Price Two Axis Endeavour Robot Provides 200mm of addressable space on both the EN22020 $5, X- and Y-axes. Y-axis supports 9 pounds. Dim: 320 x 405 x 320 mm (W x D x H). Two Axis Endeavour Robot Provides 400mm of addressable space on both the EN , X- and Y-axes. Y-axis supports 9 pounds. Dim: 520 x 605 x 320 mm (W x D x H). Three Axis Endeavour Robot Provides 200mm of addressable space on both the EN , X- and Y-axes and 100mm of stroke length in the Z-dimension. Z axis supports up to 4.5 pound loads. Dimensions: 330 x 405 x 420 mm (W x D x H). Three Axis Endeavour Robot Provides 400mm of addressable space on both the EN , X- and Y-axes and 100mm of stroke length in the Z-dimension. Z axis supports up to 4.5 pound loads. Dimensions: 530 x 605 x 420 mm (W x D x H). Endeavour Software Catalog # Price Endeavour.dll Software support for the Endeavour robot. N. C. AutoKem Software Source code in VB.Net 2008 for the Endeavour robot. AutoKem $ Call J-KEM for complete function list. Specifications for all Endeavor Robots Call for drill guides and additional specifications. Speed: mm/sec Positional Accuracy: 0.02 mm I/O: 16 general purpose optically isolated logic level inputs and 16 open collector optically isolated outputs (100 ma). +24 V & Gnd. Communications: USB and RS232 Power: Vac input; 200 watts J-KEM Scientific Toll-free: (800) Fax: (314) info@jkem.com Page 7

7 Robotic Workstation Accessories Robotic Shaker Specially designed for robotic applications, this low profile shaker is less than 5 tall. The key feature of the RS2000 is its ability to home to an absolute X- and Y-coordinate when stopped with accuracies better than 0.1mm in both the X and Y dimensions. Homing to a known coordinate allows the robot to reliably access modules attached to the shaker s mounting plate. Triple eccentric drives provide vigorous mixing of loads up to 60 pounds. Catalog # RS2000 Specifications: Price $5, Dimensions: Rotational speeds: Maximum load: Shaking motion: Orbital radius: Communications: x 20 x 4.75 (WxDxH) rpm 60 pounds Orbital or linear 0.4 Can be customized USB, RS232, RS485, binary, manual Solid Phase Extraction Station The KEE-100 automates 24-positions of solid phase extraction. The KEE-100 works by regulating the solvent flow rate and optically monitoring the position of the solvent front above the top of the column packing in each column individually. When the solvent front reaches the top of the packing, a Teflon valve closes preventing the packing from going dry. Individual control of solvent flow rate and position ensure reproducible results. SPE columns can be developed either by vacuum or positive pressure. Optical sensors Teflon valve 24-microcontrollers Inside the KEE-100 Specifications: 24 Positions Column diameter: 1/8 to 1 Solvent compatibility: Organic & aqueous Flow rates: 0.05 to 4mL/min Includes: SPE station and computer controller Multi-Position Syringe Pumps KEE-100 Price: $25,200 Custom syringe pumps with 4 to 48 glass and Teflon syringes. Syringe pump controller (included) regulates the rate and volume of dispense and fill cycles and automatically refills syringes when needed. Dispenses from one or all syringes in parallel. Syringe sizes from 10 µl to 50 ml. See page 10 for additional syringe pump options Prices varies depending on syringe size and features 8-Position pump: From $8, Position pump: From 10, Position pump: From 14, Position pump: From 19,440 J-KEM s engineers design whatever is needed to efficiently automate your laboratory task Custom Modules Custom Fluid Dispensing Options Heated and Cooled Reactors for incubations and crystallizations 4-Position Sonicater Page 8 Florescence Probe on Z-arm Temp. Controlled Filter Station J-KEM Scientific Toll-free: (800) Fax: (314) info@jkem.com

8 Capping & Uncapping Station J-KEM s capping module automates the removal and replacement of caps from sample vials. The capper removes, then replaces one cap at a time eliminating the possibility of cross contamination. The top and bottom grippers automatically adjust to caps with diameters from 8 mm to 26 mm (2 ml to 20 ml vials) with no tooling changes, and can be adjusted for cap diameters up to 35 mm and vial heights of 125 mm. Thread pitch, the number of turns needed to remove a cap, and recapping torque are all software programmable. Available with RS232 or USB. Capping Station Features: Automatically adjusts for - Cap diameter - Vial height - Thread pitch Adjustable capping force No limit on the number of turns Fraction Collectors Price $12,750 The capping station mounted to a J-KEM weighing robot J-KEM manufactures custom fraction collectors for any research application, from a simple 2 axis to a sophisticated 3 axis instrument running a custom, user specified, program. Features: External inputs & outputs for tube advance Collect to a single or multiple racks Fractions taken as a function of: - Time - Input voltage - User specified parameter Custom inputs/outputs to interface with other instruments Custom fraction collector holds 12 microtiter plates The Endeavour s affordable price makes it a perfect intelligent fraction collector. The Endeavour can be programmed to collect fractions based on any input parameter and according to any pattern. For example: 1) Place the fi rst 40% and the last 40% of any peak in one common test tube, but put the middle 20% in a GC vial for analysis. 2) Collect each peak to a single tube. After the fractionation process is done, go back and transfer 1mL of each collected peak to a GC vial for analysis. This is great stuff, but what I really need is... J-KEM welcomes the opportunity to work with you on any automation project. Put our experience in robotics, reactor design, fluidics, and custom programming to work for you. J-KEM Scientific Toll-free: (800) Fax: (314) info@jkem.com Page 9