Epitomics Product List

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2 An t i b 00% SATISFACTION An t i Epitomics Product List The New Generation of Antibodies - RabMAbs The high affinity of rabbit antibodies combined with the specificity of a monoclonal. Every RabMAb is tested in multiple applications before being released, IHC, ICC, IP and Flow Cytometry. Ideal for use with mouse or rat tissues. RabMAbs combine the advantage of high affinity, attributable to their rabbit origin with high specificity due to their monoclonal nature. The high affinity and low background of RabMAbs makes them ideal affinity reagents for demanding applications such as the detection of antigens in formalin fixed paraffin embedded tissue sections. The availability of the first suitable rabbit fusion partner cell line, created in 1995 by Dr. Katherine Knight (1), enabled the generation of stable rabbit hybridomas. Epitomics further developed this cell line and established a robust system allowing for the creation of rabbit monoclonal antibodies on a larger scale. Using this proprietary rabbit monoclonal antibody (RabMAb) technology, Epitomics has developed a large number of antibodies which perform well in a variety of immunoassays (Fig.1). References 1. Spieker-Polet et al., (1995) PNAS 92, Rossi, S. et al., (2005) Am J Clin Pathol 124, Ramos-Vara (2005) Vet. Pathol. 42, Learn More at Figure 1. General procedure Epitomics uses for making rabbit monoclonal antibodies. Epitomics Antibody Guarantee - We ve got your back! Quality Antibodies Epitomics is committed to producing quality antibodies utilizing our proprietary rabbit fusion partner technology which produces antibodies with high affinity and specificity. Extensive Product Characterization Every Epitomics antibody is always tested in five different assays (, IHC, ICC/IF, FC, and IP) and in multiple species (Human, Mouse, and Rat). For more information, please visit B e t t e r B e t t e r An t i b o d i e s 100% SATISFACTION GUARANTEE S c i e n c e 100% Satisfaction Guarantee We guarantee every antibody to work as described on the product datasheet. If any product purchased from Epitomics does not perform as indicated please contact us and we ll try and help you to get it working. We ll replace or refund any product that doesn t perform as indicated on our datasheet. B e t t e r B e t t e r An t i b o d i e s 100% SATISFACTION GUARANTEE 100% SATISFACTION GUARANTEE S c i e n c e Epitomics, Better Antibody, Better Science UALITY ASSURANCE Visit for new products and promotions

3 Spring 2010 Contents 4 New Epitomics website Epitomics Online Updated website featuring easy online ordering Ordering Information 4 4 International Distributors 5 Product References 6-7 Latest published articles citing Epitomics products and services 9 Human Akt1 ELISA Kit Rabbit vs. Mouse MAb Product Spotlight: 8 Human Akt1 ELISA Kit 9 Thiophosphate Ester RabMAb 10 BioActive RabMAbs 11 Products Primary Antibodies 12 New RabMAbs Over 1600 antibodies including 200+ new antibodies made using Epitomics RabMAb technology Antibodies # - D Antibodies E - K Antibodies L - Q Antibodies R - Z Support Products Services 63 Custom Antibodies Kits (ELISA, IHC, Purification) Custom Antibody Services Epitomics is dedicated to providing a superior, highly customized service to fulfill your antibody needs. We can help with any or all stages of your project Custom Polyclonal Antibody Production Services Custom Monoclonal Antibody Production Services Antigen Design Services Antibody Production and Purification Services Assay Development 3

4 International Distributors Epitomics Online Relaunched! Discover anything to everything related to Epitomics proprietary technology and latest offerings on our comprehensive web site. Convenient With Epitomics Online you have access to Epitomics products, services, and protocols at your finger tip - 24 hours, 7 days a week. Easy and secure 24 hour online ordering system Easy online access to latest products and services from Epitomics Real-time pricing and availability information Comprehensive Over 1600 Rabbit Monoclonals online with complete product information All recommended protocols available for download on technical support page Each product page provides in-depth product information including protein background information, confirmed assays with images (, IHC, ICC, IP, FC) and species cross-reactivity (Human, Mouse, Rat) information. Recommended protocols and technical support guides are also available on our technical support page. Multiple Online Tools Portals - IHC, Antibody Kits, Custom Antibodies and more Fully interactive pathway maps to popular cellular pathways Find all things RabMAbs at Ordering Information Ordering: Please place order by Phone, Fax, or Web site Phone: (Toll Free) or Monday through Friday from 9AM to 5PM Pacific Standard Time (excluding holidays). Fax: [email protected] On-line: When placing your order please be prepared to provide the following information: Purchaser s name and telephone number End user s name and telephone number Shipping address Billing address Purchase order number or credit card (VISA and MASTER CARD only) Catalog number and product description Size and quantity of product desired Please note: A Credit Application may be required to be filled out before PO s can be accepted. Payment Terms We accept payments using VISA and MASTER CARD We also accept purchase orders from credit approved institutions. For More Information on Ordering, Please Visit Over 1600 Product pages with comprehensive product information Shipping: Epitomics, Inc. attempts to ship all orders within 24 hours following the order placement. All orders are shipped F.O.B. Burlingame, CA. Shipping and handling charges are prepaid and added to your invoice. Orders are shipped via Federal Express. Handling fees may include fee for dry or blue ice when applicable. At the time of order we will provide shipping and delivery estimates based on the availability of the items. Applicable shipping and handling fees will also be provided at the time of order. Order Cancellations: Orders for catalog products can be cancelled at no charge provided that the notice of cancellation is made before the order is shipped. Cancellations received after the order has shipped may be subject to a 20% return and re-stocking fee. For products that are temperature sensitive, order cancellations may not be available. Returns: To return improper or incomplete products please call our customer service department within 72 hours after receipt of the order to obtain a return authorization. Argentina AntibodyBcn S.L. Tel: (+34) [email protected] Web: Australia Australian Biosearch Tel: +61 (0) Fax: +61 (0) [email protected] Web: com.au Austria BIOMOL GMBH Tel: (49) Fax: (49) [email protected] Website: Baltic States BIOMOL GMBH Tel: (49) Fax: (49) [email protected] Website: Belgium Bio-Connect B.V. Tel: +31 (0) FAX: +31 (0) [email protected] Website: Brazil Life Sciences - Ltda Tel/Fax: [email protected] Website: com.br Canada CedarLane Laboratories Ltd. Toll Free: Tel: Fax: general@cedarlanelabs. com Website: Chile AntibodyBcn S.L. Tel: (+34) [email protected] Web: China Hangzhou HuaAn Biotech Co. Ltd Tel: Fax: [email protected] Website: NeoBioscience Technology Co., Ltd Tel: , Fax: [email protected] Web: Czech Republic BIOMOL GMBH Tel: (49) Fax: (49) [email protected] Website: Denmark Nordic BioSite AB Free Phone: Fax: +46 (0) [email protected] Website: Finland Nordic BioSite AB Free Phone: Fax: +46 (0) [email protected] Website: France EUROMEDEX Tel: Fax: Website: Germany BIOMOL GMBH Tel: (49) Fax: (49) Freecall (Germany only): Freefax (Germany only): [email protected] Website: Greece Biodynamics S.A. Tel: Fax: Biodynamics.S.A@ biodynamics.gr Hungary BIOMOL GMBH Tel: (49) Fax: (49) [email protected] Website: India GUARAV ENTERPRISE Tel: Fax: [email protected] GeneX Phone: Fax: [email protected] Website: Ireland Insight Biotechnology Ltd Tel: +44 (0) Fax: +44 (0) [email protected] Website: Israel Almog Diagnostic Tel: Fax: [email protected] Website: Italy DBA Italia s.r.l. Tel: Fax: [email protected] Website: Histoline Phone: Fax: [email protected] Website: Japan COSMO BIO Co., Ltd. Tel: Fax: [email protected] Website: Korea Essence Medical, Inc. Tel: Fax: [email protected] Website: Luxembourg Bio-Connect B.V. Tel: +31 (0) Fax: +31 (0) [email protected] Website: Malaysia Biomarketing Services Sdn. Bhd. Tel: (+603) Tel: (+603) Fax: (+603) [email protected] Website: Mexico Biosistemas Avanzados S.A. de C.V. Tel: +52 (55) 5559_6852 FAX: +52 (55) 5559_ [email protected] Website: Netherlands Bio-Connect B.V. Tel: +31 (0) FAX: +31 (0) [email protected] Website: Norway Nordic BioSite AB Tel: Fax: +46 (0) [email protected] Website: New Zealand Australian Biosearch Tel: +61 (0) Fax: +61 (0) [email protected] Web: Poland BIOMOL GMBH Tel: (49) Fax: (49) [email protected] Website: Russia OOO Microtests in bio, med, vet Phone: (7) Fax: (7) [email protected] Website: Singapore BST Scientific Pte Ltd Tel: Fax: [email protected] Website: Spain ATOM S.A. Tel: Fax: Website: AntibodyBcn S.L. Tel: (+34) [email protected] Web: Sweden Nordic BioSite AB Tel: +46 (0) Fax: +46 (0) [email protected] Website: Switzerland LabForce AG Tel: +41 (0) Fax: +41 (0) [email protected] Website: Taiwan Excel BioMedical Inc. Tel: Fax: [email protected] Website: Hong Jing Co. Phone: Fax: [email protected] Website: Thailand Biomed Diagnostics Tel: (66) , (66) Fax: (66) [email protected] Website: Turkey BioGen Medical Instruments Trading Co. Ltd Tel: Fax: [email protected] Website: United Kingdom Insight Biotechnology Ltd Tel: +44 (0) Fax: +44 (0) [email protected] Website: Stratech Scientific Ltd Phone: +44 (0) Fax: +44 (0) [email protected] Website: USA Epitomics, Inc. Tel: Fax: [email protected] Website: Other Countries: Please contact Epitomics directly 4 5

5 Product References Product References Here is a sample of the latest references citing Epitomics Rabbit Monoclonal Antibodies (RabMAbs ). please contact [email protected] or visit For more product references, Antibody Cat# References Applications Antibody Cat# References Applications ABCG1, LCAT The reverse cholesterol transport system as a potential mediator of luteolysis in the primate corpus luteum Randy L Bogan and Jon D Hennebold, Reproduction, Jan 2010; 139: Ki Molecular mechanism by which pioglitazone preserves pancreatic β-cells in obese diabetic mice: evidence for acute and chronic actions as a PPAR gamma agonist Yukiko Kanda et al., Am J Physiol Endocrinol Metab, Feb 2010; 298: E278 - E286. IHC Actin Akt Alpha-Actinin AMPK beta Catenin beta CDX c-kit C-reactive protein (C-term) Cellular Plasticity of Inflammatory Myeloid Cells in the Peritoneal Foreign Body Response Jane E. Mooney et al., Am. J. Pathol., Jan 2010; 176: Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells Saskia M. Brachmann et al., PNAS, Dec 2009; 106: Alpha Actinin2 cytoskeletal protein is required for the functional membrane localization of a Ca 2+ -activated K + channel (SK2 channel) Ling Lu et al., PNAS, Oct 2009; 106: AMPK β1 Deletion Reduces Appetite, Preventing Obesity and Hepatic Insulin Resistance Nicolas Dzamko et al., J. Biol. Chem., Jan 2010; 285: ALX4 dysfunction disrupts craniofacial and epidermal development Hulya Kayserili et al., Hum. Mol. Genet., Nov 2009; 18: GATA3 Is Selectively Expressed in the Trophectoderm of Peri-implantation Embryo and Directly Regulates Cdx2 Gene Expression Pratik Home et al., J. Biol. Chem., Oct 2009; 284: Integrated Molecular and Clinical Analysis of AKT Activation in Metastatic Melanoma Michael A. Davies et al., Clin. Cancer Res., Dec 2009; 15: Human C-Reactive Protein Does Not Promote Atherosclerosis in Transgenic Rabbits Tomonari Koike et al., Circulation, Nov 2009; 120: ICC ICC Affinity Purification Lamin B Receptor Lyn Phospho (py396) MEKK , Paxillin PKR Phospho (pt446) Raf Induction of a Massive Endoplasmic Reticulum and Perinuclear Space Expansion by Expression of Lamin B Receptor Mutants and the Related Sterol Reductases TM7SF2 and DHCR7 Monika Zwerger et al., Mol. Biol. Cell, Jan 2010; 21: Activities of SYK and PLC gamma 2 Predict Apoptotic Response of CLL Cells to SRC Tyrosine Kinase Inhibitor Dasatinib Zibo Song et al., Clin. Cancer Res., Jan 2010; 16: PB1 Domain Interaction of p62/sequestosome 1 and MEKK3 Regulates NF-B Activation Kazuhiro Nakamura et al., J. Biol. Chem., Jan 2010; 285: Homocysteine promotes vascular smooth muscle cell migration by induction of the adipokine resistin Changtao Jiang et al., Am J Physiol Cell Physiol, Dec 2009; 297: C C1476. Mechanisms of Protein Kinase PKR-Mediated Amplification of Beta Interferon Induction by C Protein-Deficient Measles Virus Christopher S. McAllister et al., J. Virol., Jan 2010; 84: Acute Insulin Signaling in Pancreatic Beta-Cells Is Mediated by Multiple Raf-1 Dependent Pathways Emilyn U. Alejandro et al., Endocrinology, Jan 2010; /en , ICC ICC Cytokeratin 4, 5, 6a, , , Recovery of Multipotent Progenitors from the Peripheral Blood of Patients Requiring ECMO Support Kim Chi T Bui et al., Am. J. Respir. Crit. Care Med., Oct 2009 IHC RSK1 Phospho (ps380) Regulation of Protein Kinase A Activity by p90 Ribosomal S6 Kinase 1 Xianlong Gao and Tarun B. Patel, J. Biol. Chem., Nov 2009; 284: ELK Elucidation of the ELK1 target gene network reveals a role in the coordinate regulation of core components of the gene regulation machinery Joanna Boros et al., Genome Res., Nov 2009; 19: Smad Bright-Field Microscopy Visualization of Proteins and Protein Complexes by In Situ Proximity Ligation with Peroxidase Detection Agata Zieba et al., Clin. Chem., Jan 2010; 56: IHC Ezrin Differential proteome analysis of human gliomas stratified for loss of heterozygosity on chromosomal arms 1p and 19q Michael Grzendowski et al., Neuro Oncology, Jan 2010; /neuonc/nop025. VEGFR Soluble-Flt-1 Gene Therapy Ameliorates Albuminuria, but Accelerates Tubulointerstitial Injury in Diabetic Mice. Tomoki Kosugi et al., Am J Physiol Renal Physiol, Dec 2009; FAK Phospho (py576) Fibronectin Neutrophil granulocytes promote the migratory activity of MDA-MB-468 human breast carcinoma cells via ICAM-1 Strell C et al., Exp Cell Res. 316(1):138-48, 2010 Differential proteomic characterization between normal peritoneal fluid and diabetic peritoneal dialysate Hsien-Yi Wang et al., Nephrol. Dial. Transplant., Jan 2010; /ndt/gfp696. VLA Well Plate Coupled Microfluidic Devices Designed for Facile Image-Based Cell Adhesion and Transmigration Assays Carolyn G. Conant, Michael A. Schwartz, and Cristian Ionescu-Zanetti J Biomol Screen, Jan 2010; 15: ICC GAPDH GSK3 beta A Novel Mouse Model for De novo Melanoma Mayuko Y. Kumasaka et al., Cancer Res., Jan 2010; 70: Deregulated GSK3β Sustains Gastrointestinal Cancer Cells Survival by Modulating Human Telomerase Reverse Transcriptase and Telomerase Wei Mai et al., Clin. Cancer Res., Nov 2009; 15: IHC More Product References HIAP A Novel Paradigm to Trigger Apoptosis in Chronic Lymphocytic Leukemia Sandra Loeder et al., Cancer Res., Dec 2009; 69: Histone H3 Acetyl (K56) Systematic in vivo structure-function analysis of p300 in hematopoiesis Erin A. Kimbrel et al., Blood, Nov 2009; 114: JNK Identification of a Novel Amino Acid Response Pathway Triggering ATF2 Phosphorylation in Mammals Cédric Chaveroux et al., Mol. Cell. Biol., Dec 2009; 29:

6 Comparison - RabMAb vs. Mouse MAb Advantages of Rabbit Monoclonals Product Spotlight New! Human Akt1 ELISA Kit Rabbit Monoclonal Antibodies (RabMAbs ) provide the combined benefits of superior antigen recognition of the rabbit immune system with the specificity and consistency of a monoclonal antibody, bringing you the highest quality antibody possible. To evaluate the specificity and sensitivity of Epitomics RabMAbs, we compared various diagnostic marker specific RabMAbs with the leading commercially available Mouse Monoclonal counterparts. Both antibodies were tested on the same formalin fixed paraffinembedded tissue sample and under their recommended immunohistochemistry conditions. Specific to Human Akt1 protein. No cross-reactivity to Mouse and Rat Akt1 protein. Simple and Fast ELISA kit utilizing Epitomics RabMAb antibody technology. The results shown below demonstrate that Epitomics RabMAbs have higher sensitivity combined with lower background than the comparable mouse monoclonal antibodies. In conclusion, Epitomics RabMAbs are proving to be exceptional affinity reagents for the detection of key diagnostic and prognostic markers in formalin fixed and paraffin embedded (FFPE) tissue sample. CDX2 RabMAb Mouse MAb View More Antibody Comparisons Fig 1. ELISA analysis using Human Akt1 ELISA Kit (Cat# ). A) The amount of protein used for ELISA shown in Western Blot and the relationship between the protein concentration of lysates from MCF7 cells and assay optical density readings. B) The relationship between protein concentration of Jurkat cell lysates with or without treatment of LY and kit assay optical density readings Antibody Name Catalog # Applications Species CDX , IHC, ICC, FC Human Akt1/PKBa is a Ser/Thr protein kinase whose kinase activity plays a key role in various cellular functions, including apoptosis, glycogen synthesis, and cell growth. Akt1/PKBa is activated by various growth and survival factors. Phosphorylation on Thr308, Ser473 and Tyr474 is required for full activity. Akt1/PKBa inhibits apoptosis by phosphorylating and inactivating several targets, including caspase-9. Akt1/PKBa regulates glycogen synthesis by phosphorylating and inactivating glycogen synthase kinase-3a and b. Three mammalian Akt1/PKBa isoforms have been identified. Paraffin-embedded human colonic carcinoma tissue stained with Epitomics CDX2 RabMAb (Cat# ) and Vendor A s CDX2 Mouse Monoclonal (both at 1:1000 dilution factor) Cathepsin D RabMAb Mouse MAb Antibody Name Catalog # Applications Species Cathepsin D , IHC, ICC. FC. IP Human, Mouse Cathepsin D , IHC, ICC Human Cathepsin D (Pro) , IHC, ICC Human Fig 2. 5 Steps of Sandwich ELISA assay. Paraffin-embedded human breast ductal infiltrating carcinoma tissue stained with Epitomics Cathespsin D RabMAb (Cat# , at 1:500 dilution factor) and Vendor A s Cathespin D Mouse Monoclonal (at 1:50 dilution factor) Her2 This assay employs the sandwich enzyme immunoassay technique that detects human Akt1. Rabbit anti-akt1 monoclonal antibody has been pre-coated onto a microplate. Cell lysate is pipetted into the wells. Following extensive washing, mouse anti-human Akt1 monoclonal antibody reagent is added. Following a wash to remove any unbound antibody reagent, goat anti-mouse IgG-HRP is added to the well. After washing away the unbound goat anti-mouse IgG-HRP, a substrate solution is added to the wells to develop color. The magnitude of the absorbance for this developed color is proportional to the amount of human Akt1 protein. RabMAb Mouse MAb ELISA Kit Catalog # Type Species Reactivity Price New Akt1 (Human Specific) Sandwich ELISA (96 Reactions) Human $450 8 Paraffin-embedded human breast carcinoma tissue stained with Epitomics Her2 RabMAb and Vendor D s Her2 Mouse Monoclonal (both at 1:500 dilution factor). Antibody Name Catalog # Applications Species Her , IHC, FC, IP Human, Mouse Her IHC Human Her2 (py877) , ICC Human Her2 (py1139) , FC, IP Human Related Products Antibody Catalog # Applications Species Reactivity Price Akt , IHC, ICC, IP Human, Mouse, Rat $250 Akt1 Phospho (ps473) , IHC, ICC Human, Mouse $285 Akt1 Phospho (pt308) Human, Mouse $285 Akt Substrates Ab Sampler Kit , IHC, ICC, IP, FC Human, Mouse, Rat $535 For More Information - Visit 9

7 Product Spotlight Product Spotlight Thiophosphate Ester RabMAb (Clone 51-8) BioActive Rabbit Monoclonal Antibodies A Novel Rabbit Monoclonal for the Detection of Kinase Substrates Monoclonal Antibody featured in J. Allen, et al. Nature Methods 2007 paper (6) Epitomics RabMAb technology allows the development of monoclonal antibodies with superior antigen recognition and versatile for various demanding applications. Utilizing these unique benefits, Epitomics has developed high quality rabbit monoclonals for neutralization and/or activation for biological activity studies to various protein targets. Identify known and novel substrates to various kinases Fully validated for neutralization and/or proliferation studies, ELISA, and Detect context independent serine, threonine, and tyrosine phosphorylated proteins High specificity for the target protein, leading to efficient neutralization or activation of biological activities Half maximal inhibitory concentration (IC50) available for each antibody Neutralization Neutralizing a specific target of protein with BioActive antibodies can give valuable insight into protein s biological activities. Additionally, neutralization can be utilized to assist in measuring the biological activity of samples containing several bioactive proteins. Antibody Name Fig 1. Reaction sequence for affinity tagging kinase substrates. Cat # Bioactivites Applications Price GM-CSF (Bioactive) AntibodyReceptor ELISA,, Neutralization $245 New IFN Alpha (Bioactive) AntibodyReceptor ELISA,, Neutralization $245 New IL-1B (Bioactive) AntibodyReceptor ELISA,, Neutralization $245 IL-4 (Bioactive) AntibodyReceptor ELISA,, Neutralization $245 IL-6 (Bioactive) AntibodyReceptor ELISA,, Neutralization $245 IL-6R (Bioactive) AntibodyLigand ELISA,, Neutralization $245 IL-15 (Bioactive) AntibodyReceptor ELISA,, Neutralization $245 New RANKL (Bioactive) AntibodyLigand ELISA,, Neutralization $245 New TNF Alpha (Bioactive) AntibodyReceptor ELISA,, Neutralization $245 New VEGF (Bioactive) AntibodyLigand ELISA,, Neutralization $245 Epitomics Thiophosphate Ester Rabbit Monoclonal Antibody (Cat# , Clone 51-8) is designed to be used to detect proteins containing thiophosphate ester site following labeling as described by Allen and Shokat (Nature Methods 2007). Protein phospholyation is the most widespread and studied regulatory signaling mechanism that occurs in both eukaryotic and prokaryotic organisms. This mechanism of adding phosphate (PO4) to a protein by a kinase forms the basis of cell signaling networks, from controlling of various protein properties (e.g. function, structure) and to being involved in all fundamental cellular processes (1, 2, 3). However, the biochemical identification of the substrates of kinase of interest (KOI) has been challenging and limited. This is due to the low abundance of most phosphoproteins, and the low affinity and substoichemistry phosphorylation of kinase-tosubstrate interaction (1, 4). To address this limitation, a bio-orthogonal affinity purification and identification of direct kinase substrates has been introduced (6). First, KOI accepts ATPγS, then it is allowed to thiophosphorylate its direct substrates. Second, the thiophospholyation site on the substrates is alkylated with p-nitrobenzylthiophosphate (PNBM). Finally, a thiophosphate ester specific rabbit monoclonal antibody (clone 51-8) is introduced to identify the tagged substrates (Figure 1). This semi-synthetic epitope tagging provides a new way to identify and isolate the substrates of various kinases (4, 5, 6). New Antibody-Ligand Binding Activation/Proliferation For activation/proliferation, BioActive antibodies can be used to induce biological activities in samples by acting as the inducing agents. References: *Data provided courtesy of Dr. Shokat s lab, UCSF Fig 2. Western Blot analysis using Thiophosphate Ester Specific RabMAb (Cat# ). In vitro kinase reaction using JNK1 protein (10ng) incubated with c-jun-gst substrate (1ug) using ATPγS followed by alkylation with PNBM (2.5mM). Kinase reaction was carried out for 30 minutes at room temperature. PNBM alkylation (2.5mM) was for 2 hours at room temperature. Reaction products were analyzed by western blot with thiophosphate ester specific RabMAb (Cat# ) at 1:5000, α-gst antibody confirms equal loading. 10 Toll Free : RABMAB ( ) Johnson, S.A. and Hunter, T. Nature Methods 2, 17 25, Hunter, T. Signaling 2000 and beyond. Cell 100, , Cozzon, A.J. Ann. Rev. Microbiol. 42, , Cai, D, Article Review, Mol. BioSyst., 3, , Allen, J.J. et al. J. Am. Chem. Soc., 127(15), , Allen, J.J. et al. Nature Methods, 4(6), , Antibody Name CD40 (Bioactive) Antibody Name Cat # Type Amount Price ThioEster RabMAb RabMAb 50uL (25-50 Blots) $305 For More Information Visit [email protected] Antibody-Receptor Binding Cat # Bioactivites Applications Price AntibodyReceptor ELISA, FC, Proliferation $245 Visit for more information 11

8 # b/a (C-term) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 # b/a (N-term) RabMAb 100µl, IHC, FC Human, Mouse, Rat $250 New e (N-term) RabMAb 100µl, ICC, FC Human, Mouse, Rat $250 on (A) fetal brain, (B) SH-SY5Y, (C) 293T and (D) SW480 cell (left). ICC on HeLa (right). The epsilon protein (14-3-3E) is one of seven isoforms in the protein family; a family which consists of acidic 30 kda proteins expressed at high levels in neurons of the central nervous system. It is an adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Specificity: A synthetic peptide corresponding to residues in human E was used as an immunogen. 4-1BBL RabMAb 100µl, IHC, ICC, IP Human $250 4E-BP RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 4E-BP RabMAb 100µl, IHC, FC, IP Human $250 4E-BP1 Phospho (ps65) RabMAb 100µl Human, Mouse $285 4E-BP1 Phospho (pt37) RabMAb 100µl Human, Mouse $285 4E-BP1 Phospho (pt70) RabMAb 100µl, IHC Human $285 4E-BP1/2/3 Phospho (pt45) RabMAb 100µl, IHC, ICC, IP Human, Mouse $285 A ABCD RabPAb 100µl, IHC Mouse $250 A ABCD RabMAb 100µl Mouse $210 ABCG RabMAb 100µl, IHC, ICC Human, Mouse, Rat $250 ACACB Phospho (ps221) RabMAb 100µl Human $285 ACADM RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 New ACADM RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 New ACAT RabPAb 100µl, IHC, ICC Human, Mouse, Rat $250 ACAT RabMAb 100µl, FC, IP Human, Mouse, Rat $250 ACAT (C-term) RabMAb 100µl, IHC, ICC, IP Human $250 ACE (Membrane form specific) RabMAb 100µl, FC Human, Mouse $250 Acetyl CoA Carboxylase 1 (ACC1) RabMAb 100µl, IHC Human, Mouse, Rat $250 Acetyl CoA Carboxylase 1 (ACC1) Phospho (ps79) Acetyl CoA Carboxylase 2 (ACC2) Phospho (ps221) RabMAb 100µl, ICC Human $ RabMAb 100µl, IHC, ICC, IP Human $285 ACHR (Beta) RabMAb 100µl, FC Human, Mouse, Rat $250 ACHR (Beta, Extracellular) RabMAb 100µl, ICC, FC Human, Mouse, Rat $250 Actin (Alpha, Smooth Muscle) RabMAb 100µl, IHC, IP, FC Human, Mouse, Rat $250 Actins are highly conserved proteins ubiquitously expressed in all eukaryotic cells. They comprise, along with microtubules, a major component of the cytoskeleton. It is expressed in heart and skeletal striated muscle tissue, and in certain smooth muscle tissues, regulating contractile potentials for these cells. Acyl protein thioesterase RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 Adducin (Alpha, C-term) RabMAb 100µl, IHC, ICC Human, Mouse $250 Adducin Phospho (Alpha, ps481) RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $285 Adducin Phospho (Alpha, ps59) RabMAb 100µl, IP Human $285 New ADH RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 IHC on human liver Mammalian alcohol dehydrogenases (ADHs), including ADH1-ADH6, interact extensively in the oxidation and reduction of alcohols and aldehydes. ADH6 is a class V alcohol dehydrogenase, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Specificity: A synthetic peptide corresponding to residues in human ADH6 was used as an immunogen. Adiponectin RabMAb 100µl, ICC Human $250 Adiponectin RabMAb 100µl, IP Human $250 AE1 Phospho (py359) RabMAb 100µl Human $285 AFP (C-term) RabPAb 100µl, IHC Human, Rat $250 AFP (C-term) RabMAb 100µl, IHC, IP Human $250 AFP (N-term) RabPAb 100µl, IHC Human, Rat $250 AFP (N-term) RabMAb 100µl, IP Human $250 AGR RabMAb 100µl, IHC, ICC Human, Rat $250 AGR RabMAb 100µl, IHC, ICC, IP, FC Human $250 AIF RabMAb 100µl, IHC, ICC, IP, FC Human, Mouse, Rat $250 Akt RabMAb 100µl Human, Mouse $210 Akt1 (C-term) RabMAb 100µl, IHC, ICC, IP, FC Human, Mouse, Rat $250 Akt1 (Pan) RabMAb 100µl IHC, ICC, IP Human, Mouse, Rat $250 Akt1 Phospho (ps473) RabMAb 100µl, IHC, ICC Human, Mouse $285 Akt1 Phospho (pt308) RabMAb 100µl Human, Mouse $285 Aldh1A RabPAb 100µl, IHC, ICC, IP Human $250 Aldh1A RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 Aldh1A RabMAb 100µl, IHC Human $250 Aldh7A RabPAb 100µl, IHC, ICC, IP Human, Mouse $250 Aldh7A RabMAb 100µl, IHC. ICC, IP Human, Mouse $250 Aldh7A RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse $250 Aldolase B RabMAb 100µl, IP Human, Mouse, Rat $250 Aldolase B RabMAb 100µl, IHC Human, Mouse, Rat $250 Aldolase B is one of three known aldolase isoenzymes, and is found in kidney and small adult intestine where it is associated with aldolases A or C. Aldolase B catalyzes the reversible cleavage of fructose 1-phosphate into dihydroxyacetone phosphate and glyceraldehyde. It is involved in both glycolytic and gluconeogenic pathways, where its quaternary structure is critical for maintaining its full catalytic function. Specificity: A synthetic peptide corresponding to N-terminus of human Alpha-actin 3 was used as an immunogen. IHC on human uterus (left) and human skeletal muscle tissue (right) on (A) fetal liver, (B) fetal kidney cell lysate (left). IHC on human fetal liver (right). Specificity: A synthetic peptide corresponding to residues in human Aldolase B was used as an immunogen. Actin (Beta) RabMAb 100µl, IHC, ICC Human, Rat $250 Alk RabMAb 100µl IHC Human $205 Actin (Pan) RabMAb 100µl, IHC, ICC, IP, FC Human, Mouse, Rat $250 Alk Phospho (py1604) RabMAb 100µl, IHC, IP Human $285 Actopaxin Phospho (ps8) RabMAb 100µl, ICC Human, Mouse, Rat $285 Alpha B Crystallin RabMAb 100µl, IHC, ICC, FC Human $250 Acyl protein thioesterase RabMAb 100µl, ICC, FC Human, Mouse, Rat $250 Alpha B Crystallin RabMAb 100µl, IHC, ICC Human, Rat $250 Alpha-1 Catenin RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 Alpha-2 Catenin RabMAb 100µl, ICC, IP Human, Mouse, Rat $

9 Alpha-Actinin RabMAb 100µl, IHC, FC, IP Human, Mouse, Rat $250 Alpha-Actinin RabMAb 100µl, ICC, FC, IP Human, Mouse $250 Alpha-Actinin RabMAb 100µl, IHC, FC, IP Human, Mouse, Rat $250 Alpha-Actinin RabMAb 100µl, IHC, IP Human, Mouse, Rat $250 Alpha-Actinin RabMAb 100µl, IHC, ICC, FC Human, Mouse, Rat $250 AMACR RabMAb 100µl, IHC, IP Human $250 Apolipoprotein E RabMAb 100µl, IHC, ICC, IP Human, Mouse $250 Apolipoprotein E (N-term) RabMAb 100µl, IHC, FC, IP Human $250 Apolipoprotein F RabMAb 100µl, ICC Human, Mouse $250 New Apolipoprotein J RabMAb 100µl, IHC Human $250 Apolipoprotein M RabMAb 100µl, IHC, FC Human $250 New Aquaporin RabMAb 100µl, IHC, ICC Human $250 AMACR RabMAb 100µl, IHC, ICC Human, Mouse, Rat $250 Amphiphysin RabMAb 100µl, IHC, ICC, FC Human, Mouse, Rat $250 Amphiphysin RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 AMPK (Gamma 1, N-term) RabMAb 100µl, IHC, ICC, FC, IP Human $250 AMPK (Alpha 1) RabMAb 100µl, IHC, IP Human, Mouse, Rat $250 New AMPK Phospho (Alpha 1, ps487) RabMAb 100µl, ICC, IP Human $285 on (A) fetal lung and (B) SW480 cell lysates (left) IHC on human lung (right) Aquaporin 5 is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions. Expression of Aquaporin 5 may have pathophysiological implications attributed to a dysfunctional water regulation by Aquaporin 5 such as endolymphatic hydrops (i.e. in Meniere s disease) or sensorineural hearing loss. Specificity: A synthetic peptide corresponding to residues in human Aquaporin 5 was used as an immunogen. The 5-AMP-activated protein kinase (AMPK), a member of the SNF1 (sucrose nonfermentor) kinase family. AMPK is a heterotrimeric protein comprising α (63 kda), β (38 kda) and γ (38 kda) subunits. The alpha subunit is the catalytic subunit (which requires phosphorylation to be active). AMPK also appears to play a role in protecting cells from stresses that cause ATP depletion by switching off ATPconsuming biosynthetic pathways. Specificity: A phospho specific peptide corresponding to residues surrounding Serine 487 of human AMPK alpha 1 was used as an immunogen. on 293T. Cells were either (A) untreated (B) treated with LP (left). ICC on HeLa (right). AMPK (Beta 1) RabMAb 100µl, IHC, FC, IP Human, Mouse, Rat $250 AMPK Phospho (Beta 1, ps181) RabMAb 100µl, IHC, ICC Human $285 Amyloid Beta A4 Precursor (APP) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 Amyloid Beta A4 Variant 40 (Aβ40) RabMAb 100µl Human $210 Androgen Receptor RabMAb 100µl, FC Human, Mouse, Rat $250 New Angiotensin II Receptor (Type 2) RabMAb 100µl, IP Human, Mouse, Rat $250 Angiotensinogen (Precursor) RabMAb 100µl, FC, IP Human $250 New Annexin V RabMAb 100µl Human $250 AP2 (Gamma) RabMAb 100µl, FC, IP Human $250 AP2 (Gamma) RabMAb 100µl, IHC, ICC, FC Human $250 AP2 (Mu 1) RabMAb 100µl, FC Human, Mouse, Rat $250 AP2S RabMAb 100µl, ICC, FC, IP Human, Mouse, Rat $250 New Ape RabMAb 100µl, IHC Human, Mouse, Rat $250 Apaf RabMAb 100µl, IHC, ICC Human, Mouse $250 APC RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 Apolipoprotein A RabMAb 100µl, IHC, ICC, IP Human $250 Apolipoprotein AII RabMAb 100µl Human $250 New Apolipoprotein AII RabMAb 100µl, ICC, FC Human $250 Apolipoprotein AII (ApoA-II) is the second most abundant protein of the high density lipoprotein particles, accounting for 20% of protein mass of HDL. The concentration of ApoA-I and ApoA-II is inversely correlated with the frequency of heart disease in human. In studies with mice and humans, ApoA-II levels have been associated with increased susceptibility to atherosclerosis, increased free fatty acid levels, increased body fat, and increased insulin resistance ARF RabMAb 100µl, IHC, FC Human, Mouse, Rat $250 ARK1 (Beta, C-term) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 Arrestin 1 Phospho (Beta, ps412) RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $285 Arrestin1 (Beta) RabMAb 100µl, IHC, ICC, FC Human, Mouse, Rat $250 ASIP RabMAb 100µl, FC Human $250 ASK1 - See MEKK5 Asparagine Synthetase RabMAb 100µl, IHC, ICC Human, Mouse, Rat $250 ATF-1 Phospho (ps63) RabMAb 100µl, IHC, ICC Human, Mouse, Rat $285 ATF RabMAb 100µl, IHC, ICC, IP Human $250 ATF-2 (C-term) RabMAb 100µl, IHC, ICC, IP Human, Mouse $250 ATF-2 Phospho (pt71) RabMAb 100µl, ICC, IP Human $285 Atg RabMAb 100µl, IHC, ICC, FC, IP Human $250 ATM RabMAb 100µl, IHC, ICC, IP Human $250 ATM Phospho (ps1981) RabMAb 100µl, IHC, ICC, IP Human $285 ATP-citrate lyase Phospho (ps455) RabMAb 100µl, IP Human, Mouse, Rat $285 ATP-citrate lyase Phospho (pt447/ps451) RabMAb 100µl, ICC Human, Mouse, Rat $285 ATP-citrate lyase protein (C-term) RabMAb 100µl, FC, IP Human, Mouse, Rat $250 Aurora-A (C-term) RabMAb 100µl, IHC, IP Human $250 Aurora-B (N-term) RabMAb 100µl, IHC, ICC, IP Human $250 Aurora-C (N-term) RabMAb 100µl Human $210 B B RabMAb 100µl, IHC, ICC, FC Human, Mouse, Rat $250 B B RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 B7-H RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 Bad (N-term) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 Bag RabMAb 100µl, IHC, ICC, IP Human, Rat $250 Bag-1 (C-term) RabMAb 100µl IHC, ICC Human, Rat $250 Bag RabMAb 100µl, IHC, ICC, FC, IP Human $250 on human plasma ICC on HepG2 cells Specificity: A synthetic peptide corresponding to residues in human Apolipoprotein AII (ApoA-II) was used as an immunogen. as an immunogen. Bag RabMAb 100µl, ICC Human, Mouse, Rat $250 New Bag RabMAb 100µl, IP Human $250 Apolipoprotein CIII RabMAb 100µl, FC, IP Human $

10 Bak RabMAb 100µl, IHC, ICC, FC Human $250 Bax RabMAb 100µl, IHC, IP Human, Mouse, Rat $250 Bcl-2 Family Sampler Kit RabMAb 40µl per Ab, IHC, ICC, IP, FC Human, Mouse, Rat $595 IHC on prostate carcinoma with Bcl-x RabMAb (Left) ICC on human lymphoma with Bad RabMAb (Right) The Bcl-2 family of proteins regulate apoptosis by controlling mitochondrial permeability and release of cytochrome c. Bcl-2 is an anti-apoptotic protein that resides in the outer mitochondrial wall and inhibits release of cytochrome c. Bcl-x is expressed as two isomeric forms, Bcl-xL and BclxS and functions to inhibit apoptosis. Bcl-xL forms heterodimers with various proteins, including Bax, Bak and Bcl-2, Kit Description: A sampler kit containing Rabbit Monoclonal antibodies for 8 proteins of the Bcl-2 family (Bcl-2, Bcl-x, Bim, Bid, Bad, Bak, Bag-1, Mcl-1). Bcl RabMAb 100µl, IHC, ICC, IP, FC Human, Mouse $250 Bcl-2 related protein A1 (N-term) RabMAb 100µl, IHC, ICC, FC Human, Mouse $250 Bcl-6 (C-term) RabMAb 100µl, IHC, ICC, IP Human $250 Bcl RabMAb 100µl, FC, IP Human $250 Bcl-10 (C-term) RabMAb 100µl, IHC, ICC, IP Human $250 Bcl-x RabMAb 100µl, IHC, ICC, IP, FC Human, Mouse, Rat $250 Bcr (C-term) RabPAb 100µl IHC, ICC, IP Human $250 Bcr (C-term) RabMAb 100µl, IHC, ICC, FC, IP Human $250 Bcr Phospho (py177) RabMAb 100µl Human $285 Beclin RabMAb 100µl, IHC, ICC, IP Human $250 Beta Actin - See Actin (Beta) Beta ARK1 - See ARK1 Beta Arrestin - See Arrestin Beta Catenin - See Catenin Beta Synuclein - See Synuclein Beta Tubulin - See Tubulin Beta-2-Microglobulin RabMAb 100µl, ICC, FC, IP Human, Mouse, Rat $250 Beta-Catenin Like Protein RabMAb 100µl, FC Human $250 Beta-Catenin Like Protein RabMAb 100µl, IHC, ICC, FC, IP Human $250 Beta-Dystroglycan RabMAb 100µl Human $210 Beta-Synuclein RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 Bmx - See Etk B-Myb Phospho (pt487) RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $285 ICC on HeLa cell lysate (Left) IHC on human urinary bladder carcinoma (Right) Expression of the B-Myb transcription factor is up regulated during late G1 phase of the cell cycle by an E2F-dependent transcriptional mechanism. B-Myb is specifically phosphorylated during S phase, suggesting that a cyclin-dependent kinase (Cdk) regulates its activity. Data indicate that phosphorylation by cyclin A/Cdk2 is directly involved in enhancing B-Myb transactivation activity and that levels of endogenous cyclin A/Cdk2 activity may contribute to cell line-specific B-Myb function. Specificity: A phospho specific peptide corresponding to residues surrounding threonine 487 of human B-Myb was used as an immunogen. b-myc RabMAb 100µl Mouse, Rat $210 New BNP RabMAb 100µl Human $210 B-Raf RabMAb 100µl, IHC, FC, IP Human, Rat $250 B-Raf Phospho (pt401) RabMAb 100µl, IP Human, Mouse, Rat $285 New BRG RabMAb 100µl Human $210 New BRG RabMAb 100µl, IHC, ICC Human $250 Brn-3a RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 Btk (C-term) RabMAb 100µl, IP Human $250 Btk Phospho (py223) RabMAb 100µl, IP Human $285 Btk Phospho (py551) RabMAb 100µl, ICC Human $285 C C/EBP (C-term) RabMAb 100µl, ICC, IP Human, Rat $250 C C/EBP (N-term) RabMAb 100µl, FC, IP Mouse, Rat $250 C/EBP alpha (C-term) RabMAb 100µl, FC, IP Human, Mouse, Rat $250 C/EBP alpha (N-term) RabMAb 100µl, ICC, FC, IP Human, Rat $285 C1q (Subunit A) RabMAb 100µl, IHC, ICC, FC Human $250 C1q (Subunit B) RabMAb 100µl Human $250 New C1q (Subunit B) RabMAb 100µl, IHC, ICC Human $250 The complement component C1 is a protein complex that consists of six subunits of C1q. Each C1q subunit of the complex is known to bind to immune complexes, which often are deposited in basement membrane. C1q is a versatile recognition protein that triggers activation of the classical pathway of complement. A modular organization has been suggested of the globular domain, consistent with the view that A, B, and C chains are functionally autonomous modules and have distinct and differential ligand-binding properties. Bfl1 See Bcl-2 related protein A1 Bid RabMAb 100µl, IHC, ICC, IP, FC Human $250 on human plasma cell lysate (Left) IHC on human kidney (Right) Specificity: A synthetic peptide corresponding to residues in human C1q (subunit B) was used as an immunogen. Bim RabMAb 100µl, IHC, ICC, IP Human $250 BIR3 - See HIAP-1 BLNK RabMAb 100µl, IHC, IP Human, Mouse $250 New BM RabMAb 100µl, IHC Human, Mouse, Rat $250 on (A) fetal brain, (B) Neuro-2a and (C) SH- SY5Ycell lysates (Left) IHC on human tonsil (Right) BM88 is a neuron-specific protein widely distributed in the nervous system and implicated in cell cycle exit and differentiation of neuronal precursors. It is an integral membrane protein, which appears early during brain development and remains at high levels at the mature statebm88 is crucial for the transition from neuroblasts to mature neurons when reaching high levels. Specificity: A synthetic peptide corresponding to residues in human BM88 was used as an immunogen. C1q (Subunit C) RabMAb 100µl, IHC, ICC Human $250 C1q (Subunit C) RabMAb 100µl, IHC, ICC, FC, IP Human $250 New C RabMAb 100µl Human $210 c-abl RabMAb 100µl, IP Human, Rat $250 CAD protein RabMAb 100µl, IHC, ICC Human $250 CAD protein (N-term) RabMAb 100µl, ICC, FC, IP Human, Mouse, Rat $250 Cadherin 1 - See E-Cadherin Cadherin 2 - See N-Cadherin Cadherin 5 - See VE-Cadherin Calcitonin RabMAb 100µl IHC Human, Mouse, Rat $205 BM RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 Calcium/Calmodulin Kinase IV (CaMKIV) Calcium/Calmodulin Kinase IV (CaMKIV) RabMAb 100µl, ICC Human, Mouse, Rat $ RabMAb 100µl, IHC, FC, IP Human $

11 Caldesmon (CaM) RabMAb 100µl, IHC, ICC, IP, FC Human, Mouse, Rat $250 Caldesmon (CaM) RabMAb 100µl, IHC, ICC, IP Human $250 Caldesmon Phospho (pt730) RabMAb 100µl, IP Human, Mouse, Rat $285 Caldesmon Phospho (pt753) RabMAb 100µl, ICC Human $285 on HeLa cell. Cells were either (A) untreated (B) treated with Calyculin A. Caldesmon stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, caldesmon inhibits the actomyosin ATPase by binding to F-actin. This inhibition is reduced by calcium-calmodulin and is promoted by tropomyosin. Phosphorylation of non-muscle caldesmon has been linked to reduction of caldesmon s binding properties to actin, myosin, and calmodulin. Additionally, caldesmon s inhibition of actomyosin ATPase is reduced with its phosphorylation. Specificity: A synthetic phospho-peptide corresponding to residues surrounding threonine 753 of human Caldesmon was used as immunogen. Caldesmon Phospho (pt753) RabMAb 100µl, ICC Human $285 Caldesmon Phospho (ps759) RabMAb 100µl Human $285 Calmodulin (CaM) (C-term) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 Calnexin RabMAb 100µl, IHC, IP Human $250 Calpactin I Light Chain RabMAb 100µl, IHC, ICC, FC Human $250 Calpactin I Light Chain RabMAb 100µl, IHC, FC, IP Human $250 Calpain 1 (Small subunit) RabMAb 100µl, IHC, ICC, FC Human, Mouse, Rat $250 Calpain 1 (Small subunit) RabMAb 100µl, IHC, ICC, FC Human, Mouse, Rat $250 New Calpain 1 (Large subunit) RabMAb 100µl, IHC, ICC, FC Human, Mouse, Rat $250 Calpain 2 (Large Subunit) RabMAb 100µl, FC, IP Human $250 Calponin-1 (C-term) RabMAb 100µl, IHC, ICC Human, Mouse, Rat $250 New Calreticulin RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 Calretinin RabMAb 100µl Human, Mouse, Rat $210 Calretinin RabMAb 100µl, IP Human, Mouse, Rat $250 Calretinin RabMAb 100µl IHC Human, Mouse, Rat $205 Calretinin RabMAb 100µl, IHC, ICC, FC Human, Mouse, Rat $250 Calretinin is considered as a specific marker of mesothelllal cells; it is the only marker that has the utility in distinguishing between sarcomatoid mesotheliomas and sarcomatoid renal cell carcinomas. It is widely used in the panel of makers for distinguishing mesothlioma from adenocarcinoma. Along with calretinin, the panel includes E-cadherin, CEA, and cytokeratin 5/6. Caspase-3 (Active) RabMAb 100µl, IHC, ICC Human, Mouse $250 IHC on hepatocellular carcinoma Caspase-3 is a member of the apoptosis execution functional group of caspases, and is either partially or totally responsible for the proteolytic cleavage of many key proteins during apoptosis, such as poly (ADP-ribose) polymerase (PARP). Caspase-3 is a cytosolic protein found in cells as an inactive 32 kda proenzyme. It is activated by proteolytic cleavage into two active subunits only when cells undergo apoptosis. Specificity: A synthetic peptide corresponding to residues following Serine 29 of human caspase-3 (N-terminus of p17 subunit) was used as immunogen. This antibody only detects the active form of caspase-3 (p17 subunit) of Jurkat cell lysate using (A & B ) anti-pro-caspase-3 RabMAb (cat #1475-1) (C & D) anti-caspase-3 RabMAb (cat #1476-1). (A & C) Jurkat cell lysate (B & D) Jurkat cell lysate + Camptothecin Caspase-3 (Pro) RabMAb 100µl, IHC, ICC, IP, FC Human, Mouse $250 Caspase-3 (Pro) RabMAb 100µl, IHC, ICC, IP, FC Human, Mouse $250 Caspase RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 Caspase-6 (C-term) RabMAb 100µl, IHC, ICC, FC Human, Mouse $250 Caspase-6 (Pro) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 Caspase RabMAb 100µl, IHC, ICC, IP Human $250 Caspase-7 (Pro) RabMAb 100µl, IHC, ICC Human $250 Caspase RabMAb 100µl, FC, IP Human, Rat $250 Caspase-8 (N-term) RabMAb 100µl, IHC, FC, IP Human $250 Caspase-9 (Pro) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse $250 Caspase-9 (Pro) RabMAb 100µl, IHC, FC Human, Mouse, Rat $250 Caspase-10 (Pro) RabMAb 100µl, IHC, ICC, IP, FC Human $250 Catalase RabPAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 Catalase RabMAb 100µl, IHC, ICC, FC Human, Mouse, Rat $250 Catalase RabMAb 100µl, IHC Human, Mouse, Rat $250 Catenin (Beta) RabMAb 100µl, IHC, ICC, IP Human, Mouse $250 Catenin (Beta) RabMAb 100µl, FC Human, Mouse, Rat $250 Catenin (Alpha-1) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 Catenin (Alpha-2) RabMAb 100µl, ICC, IP Human, Mouse, Rat $250 Catenin Phospho (Beta, ps33ps37) RabMAb 100µl, Human $285 Catenin Phospho (Beta, pt41/pt45) RabMAb 100µl, IP Human $285 Cathepsin D (mature) RabMAb 100µl, IHC, ICC Human $250 IHC on human brain (left) and human mesothelioma (right) Specificity: A synthetic peptide corresponding to residues in human Calretinin was used as an immunogen. Cathepsin D (pro and mature) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse $250 Cathepsin D (pro) RabMAb 100µl, IHC, ICC Human $250 CaMKI RabMAb 100µl, FC, IP Human $250 CaMKI RabMAb 100µl, IHC, ICC Human, Mouse, Rat $250 CaMKII RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 New CaMKII RabMAb 100µl, IP Human, Mouse, Rat $250 Casein Kinase II (Alpha Subunit) RabMAb 100µl, IHC, FC Human, Mouse, Rat $250 Casein Kinase II (Beta Subunit) RabMAb 100µl, IHC, ICC, FC Human, Mouse, Rat $250 Caspase RabMAb 100µl, FC Human, Mouse $250 Caspase RabMAb 100µl, IP Human $250 Caspase RabMAb 100µl, IHC, ICC, IP Human, Rat $250 IHC on hepatocellular carcinoma Cathepsin D is a ubiquitously expressed lysosomal protease that is involved in proteolytic degradation, cell invasion, and apoptosis. It is suspected to play important roles in protein catabolism, antigen processing, degenerative diseases, and breast cancer progression. It is possibly involved in Alzheimer s disease-related neurodegeneration through cleavage of amyloid precursor protein into amyloidogenic components. Specificity: A synthetic peptide corresponding to residues on human Cathepsin D was used as an immunogen. on (A) MCF-7 (B) A431 and (C) SKBR3 cell lysates IHC on human breast ductall infiltrating carcinoma Caveolin-1 Phospho (py14) RabMAb 100µl, ICC, IP Human $285 Caveolin RabMAb 100µl, IHC, ICC, IP Human $250 Caveolin-2 Phospho (py27) RabMAb 100µl, IP Human $285 Cbl RabMAb 100µl, IHC, ICC Human, Rat $250 Cbl (C-term) RabMAb 100µl, ICC, FC, IP Human $250 Cbl Phospho (py674) RabMAb 100µl, ICC, FC Human $

12 Cbl Phospho (py700) RabMAb 100µl, FC, IP Human $285 Cbl Phospho (py774) RabMAb 100µl, IHC, ICC, FC, IP Human $285 c-cbl Phospho (py731) RabMAb 100µl, IP Human, Mouse, Rat $285 CCL4 - See MIP-1 CCR2/CKR2 (N-term) RabMAb 100µl IHC, ICC, IP, FC Human, Mouse $250 IHC on human spleen CCR2 is a G protein-coupled, seven-transmembrane domain receptor protein. It has been found to be a monocyte chemoattractant protein 1 (MCP-1)-specific receptor. Activation of the CCR2b isoform by MCP-1 binding has been shown to trigger intracelluluar Ca 2+ flux and activation of the Jak/Stat pathway. A variety of chemokine receptors, including CCR2, can serve as HIV fusion co-factors (4), making elucidating their specific functions important for more fully describing the process of HIV infection. Specificity: A synthetic peptide corresponding to the N-terminal residues of the human C-C chemokine receptor type 2 was used as immunogen. The antibody does not cross-react with other CCR family members. CCR3/CKR3 (C-term) RabMAb 100µl, IHC, ICC Human, Mouse $250 CCR5/CKR5 (C-term) RabMAb 100µl, FC Human, Mouse $250 CCR7/CKR RabMAb 100µl, FC Human, Mouse, Rat $250 CCR7/CKR7 (N-term) RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 CCR8/CKR8 (C-term) RabMAb 100µl, ICC Human, Mouse $250 CCR8/CKR8 (Loop 2) RabMAb 100µl, ICC, FC, IP Human, Rat $250 CCR9/CKR9 (N-term) RabMAb 100µl, ICC, FC Human, Mouse $250 New CCT-alpha RabMAb 100µl, ICC, FC, IP Human $250 CD1 alpha RabMAb 100µl, ICC Human, Mouse, Rat $250 New CD1 alpha RabMAb 100µl, IHC Human $250 CD RabMAb 100µl, ICC Human $250 CD3 epsilon RabMAb 100µl IHC, ICC, IP Human $250 CD3 epsilon RabMAb 100µl, ICC Human $250 CD3 epsilon RabMAb 100µl, IHC, IP Human $250 CD3 zeta (C-term) RabMAb 100µl, ICC, FC Human $250 CD3 zeta Phospho (py142) RabMAb 100µl, ICC, IP Human $285 CD3 zeta Phospho (py83) RabMAb 100µl, ICC, IP Human $285 CD RabMAb 100µl, ICC Human $250 CD RabMAb 100µl, IHC, ICC, IP Human $250 CD RabMAb 100µl, IHC Human $205 CD RabMAb 100µl IHC Human $205 CD8 (C-term) RabMAb 100µl, IHC, ICC Human, Mouse, Rat $250 CD8a RabMAb 100µl, IHC, ICC, FC, IP Human $250 New CD RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 CD RabMAb 100µl, ICC Human $250 CD RabMAb 100µl, FC Human, Mouse, Rat $250 CD RabMAb 100µl, ICC Human $250 CD RabMAb 100µl, IHC, ICC, FC, IP Human $250 CD RabMAb 100µl Human, Mouse, Rat $210 CD22 Phospho (py762) RabMAb 100µl, IP Human $285 CD22 Phospho (py807) RabMAb 100µl Human $285 CD22 Phospho (py822) RabMAb 100µl, FC Human $285 CD22 Phospho (py842) RabMAb 100µl Human $285 CD RabMAb 100µl IHC, IP Human $205 CD RabMAb 100µl, IHC, FC Human $250 CD29 - See Integrin Beta 1 CD RabMAb 100µl, IHC, FC Human $250 CD RabMAb 100µl, IHC, FC, IP Human $250 CD32 Phospho (py292) RabMAb 100µl, IP Human $285 CD RabMAb 100µl, IHC, ICC, FC, IP Human $250 New CD RabMAb 100µl, IHC, IP Human $250 CD40 (Bioactive) RabMAb 100µg ELISA, FC, Functional Assays CD40 Ligand - See TRAP cleavage Human $245 CD RabMAb 100µl, IHC, ICC, FC Human $250 CD RabMAb 100µl, IP Human $250 CD45 (C-term) RabMAb 100µl, IHC, FC Human $250 CD RabMAb 100µl, ICC, FC, IP Human $250 ICC on SH-SY5Y cells (Left) IHC on human astrocytoma (Right) The neural cell adhesion molecule (NCAM/CD56) has been shown to mediate homophilic cell-cell adhesion in the neuroendocrine system with interactions among immunoglobulin-like domains. It is a multifunction transmembrane protein involved in synaptic plasticity, neurodevelopment, and neurogenesis. NCAM appears on early embryonic cells and is important in the formation of cell collectives and their boundaries at sites of morphogenesis, Specificity: A synthetic peptide corresponding to residues near the C-terminus of human NCAM/ CD56 was used as an immunogen. CD RabMAb 100µl, IHC Human, Mouse, Rat $250 CD RabMAb 100µl Human, Mouse, Rat $210 New CD RabMAb 100µl, ICC Human $250 CD79a/IGBP RabMAb 100µl IHC, FC Human $205 CD79a RabMAb 100µl, IHC, FC Human $250 CD80 - See B7-1 CD86 - See B7-2 CD RabMAb 100µl, IHC, ICC Human, Rat $250 New CD RabMAb 100µl, IHC, ICC Human $250 CD RabMAb 100µl, IHC, ICC, IP Human $250 New CD RabMAb 100µl, IHC, ICC, FC, IP Human $250 CD11a RabMAb 100µl, IHC ICC, FC, IP Human $250 CD11b RabMAb 100µl, IHC, ICC, FC, IP Human $250 New CD11b RabMAb 100µl, IHC, ICC, FC Human $250 CD RabMAb 100µl, IHC, ICC, FC Human $250 CD20 (C-term) RabMAb 100µl, IHC, FC, IP Human $250 IHC on human tonsil (Left) IHC on human uterus (Right) Cluster of Differentiation 99 (CD99), also known as MIC2, is a T-cell surface glycoprotein involved in the T-cell adhesion process and spontaneous rosette formation with erythrocytes. It functions in the migration of leukocytes and the transport of ganglioside GM1 and transmembrane proteins (2). CD99 is also implicated in other cellular events such as thymocyte selection, apoptosis of neuronal cells, and T cell activation. Specificity: A synthetic peptide corresponding to the extracellular domains in human CD99 was used as an immunogen. CD RabMAb 100µl, FC, IP Human, Mouse, Rat $250 CD117 (C-term) RabMAb 100µl, IHC Human $

13 Cdc RabMAb 100µl, IP Human $250 Cdc RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 Cdc RabMAb 100µl, IHC Human $250 Cdc25C RabMAb 100µl, IHC, ICC, IP Human, Rat $250 Cdc25C (C-term) RabMAb 100µl, FC, IP Human $250 Cdc25C Phospho (ps216) RabMAb 100µl, ICC, IP Human $285 Cdc42 Phospho (ps71) RabMAb 100µl, ICC Human $285 Cdc6 Phospho (ps106) RabMAb 100µl Human $285 Cdc6 Phospho (ps54) RabMAb 100µl, ICC Human $285 Cdk2 (C-term) RabMAb 100µl, ICC, IP Human, Mouse $250 Cdk2 Phospho (pt14) RabMAb 100µl, IHC, icc, IP Human $285 Cdk2 Phospho (py15) RabMAb 100µl, IP Human, Mouse $285 Cdk RabMAb 100µl, FC, IP Human $250 Cdk5 (C-term) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 Cdk5 Phospho (py15) RabMAb 100µl, IHC Human $285 Cdk RabMAb 100µl, IHC, ICC, IP Human $250 Cdk RabMAb 100µl, IHC Human $250 CDX RabMAb 100µl, IHC, ICC, FC Human $250 CENP-A (C-term) RabMAb 100µl, IHC, ICC, FC Human, Rat $250 New CGA RabMAb 100µl, IHC Human $250 c-jun Phospho (ps73) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse $285 c-jun Phospho (pt91) RabMAb 100µl, IP Human, Mouse, Rat $285 c-jun Phospho (pt93) RabMAb 100µl, IP Human, Mouse $285 CK - See Cytokeratin c-kit / CD117 (C-term) RabMAb 100µl, IHC Human $250 CKRB/CKR11 (N-term) RabMAb 100µl, ICC, IP Human, Mouse, Rat $250 c-myb RabMAb 100µl, IHC, ICC, IP Human $250 c-myc (N-term) RabMAb 100µl, IHC, ICC, IP Human $250 c-myc Phospho (pt58/ps62) RabMAb 100µl, ICC, IP Human, Mouse $285 COPS RabMAb 100µl, ICC, FC, IP Human, Mouse, Rat $250 Cortactin RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 Cortactin RabMAb 100µl, ICC, FC Human, Mouse, Rat $250 COX RabMAb 100µl, ICC Human, Mouse, Rat $250 COX RabMAb 100µl IHC Human, Mouse, Rat $205 CPI-17 (Alpha, N-term) RabMAb 100µl, IHC, IP Human, Rat $250 C-Product - See SHH C-reactive protein (C-term) RabMAb 100µl, IHC, IP Human $250 C-reactive protein (C-term) RabMAb 100µl Human $210 New Creatine Kinase B type RabMAb 100µl, IHC, ICC, FC Human, Mouse, Rat $250 New Creatine Kinase B type RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 IHC on human placenta CGA belongs to the glycoprotein hormone alpha chain family that includes the alpha subunit of chronic gonadotropin (CG), lutenizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH). These hormones are central to the complex endocrine system that regulates normal growth, sexual development, and reproductive function. The hormones LH, FSH and TSH are secreted by the anterior pituitary gland, while CG is secreted by the placenta. Specificity: A synthetic peptide corresponding to residues at the C terminus of human CGA was used as an immunogen. Creb RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 Creb Phospho (ps133) RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $285 New c-rel RabMAb 100µl, IP Human $250 Crk RabMAb 100µl, ICC, IP Human, Mouse, Rat $250 Crk Phospho (py221) RabMAb 100µl, ICC Human $285 CrkL RabMAb 100µl, IHC, ICC, IP Human $250 New CGB RabMAb 100µl Human $210 Chk1 (C-term) RabMAb 100µl, IHC, ICC, FC Human $250 New Chk1 (C-term) RabMAb 100µl Human $210 Chk1 (N-term) RabMAb 100µl, ICC, IP Human, Mouse $250 Chk1 Phospho (ps280) RabMAb 100µl, IP Human $285 Chk1 Phospho (ps296) RabMAb 100µl, ICC Human $285 Chk2 Phospho (ps33/35) RabMAb 100µl, ICC Human $285 Chk2 Phospho (ps33/35) RabMAb 100µl, ICC Human $285 CrkL RabMAb 100µl, IHC, ICC Human $250 CrkL Phospho (py207) RabMAb 100µl, IP Human, Mouse $285 CUL RabMAb 100µl, ICC, FC Human, Mouse, Rat $250 CUL RabMAb 100µl, IHC, ICC, FC Human, Mouse, Rat $250 CUL RabMAb 100µl, FC, IP Human, Mouse, Rat $250 CUL RabMAb 100µl, FC, IP Human, Mouse, Rat $250 New CUL4A RabMAb 100µl, IHC, ICC, FC, IP Human $250 Chk2 Phospho (pt68) RabMAb 100µl, IHC, ICC, IP Human $285 Chk2 Phospho (pt68) RabMAb 100µl, IP Human $285 Chromogranin A RabMAb 100µl, IHC, IP Human $250 Chromogranin A (C-term) RabPAb 100µl, IHC, ICC Human, Mouse, Rat $250 Chromogranin A (N-term) RabPAb 100µl, IHC, ICC Human, Mouse $250 Chromogranin A (N-term) RabMAb 100µl, IHC, ICC, FC Human, Rat $250 New CITED RabMAb 100µl, IP Human $250 c-jun (C-term) RabMAb 100µl, IHC, ICC, IP Human $250 on (A) HeLa, (B) A375 and (C) 293T IHC on human breast carcinoma Cullin proteins assemble a large number of RING E3 ubiquitin ligases and regulate various physiological processes, including regulating replication and transcription, DNA repair and cell cycle progression. Two cullin 4 (CUL4) proteins, CUL4A and CUL4B, have been identified. Cul4A functions as an E3 ligase and participates in the proteolysis of several regulatory proteins through the ubiquitin-proteasome pathway. Cul4A associates with MDM2 and p53. Depletion of Cul4A leads to an accumulation of p53. Moreover, expression of Cul4A increases the decay-rate of p53 and delays the accumulation of p53 in response to DNA damage. Specificity: A synthetic peptide corresponding to residues in human CUL4A was used as an immunogen. c-jun (N-term) RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 CUL4 A/B RabMAb 100µl, IHC, FC Human, Mouse, Rat $250 c-jun Phospho (ps63) RabMAb 100µl, IHC, ICC, IP Human $285 Cyclin A RabMAb 100µl, ICC, IP Human $250 Cyclin A2 (C-term) RabMAb 100µl, IHC, ICC, IP Human $250 Cyclin B1 (C-term) RabMAb 100µl, IHC, ICC, FC, IP Human $

14 Cyclin D RabMAb 100µl, ICC, IP Human $250 Cyclin D RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 Cyclin D RabMAb 100µl, IHC, IP Human, Mouse, Rat $205 Cyclin D RabMAb 100µl, ICC, FC Human $250 Cyclin E RabMAb 100µl, ICC, FC, IP Human $250 Cyclin E RabMAb 100µl, IHC, ICC, IP Human $250 Cyclin E2 (C-term) RabMAb 100µl, IHC, ICC, FC Human, Rat $250 New Cyclin H RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse $250 New Cystatin B RabMAb 100µl, IHC, FC Human, Rat $250 New Cystatin B RabMAb 100µl, ICC Human $250 Cytochrome C RabMAb 100µl, IHC ICC, IP Human $250 Cytochrome C RabMAb 100µl, IHC, ICC, FC Human, Mouse, Rat $250 Cytochrome C Oxidase Subunit RabMAb 100µl, IHC, ICC, FC, IP Human $250 Cytokeratin Family ICC on HeLa cell lysate (Left) IHC on human ovarian carcinoma (Right) Cytokeratins (CK) are a family of structurally related proteins that form the intermediate flament cytoskeleton in epithelial cells.. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. There are two types of cytokeratins: the low molecular weight / acidic type I cytokeratins and the high molecular weight / basic or neutral type II cytokeratins. Cytokeratins are usually found in pairs comprising a type I cytokeratin and a type II cytokeratin. Type I CK group is comprised of CK10, CK12, CK 13, CK14, CK16, CK17, CK18, CK19 and CK20. While, type II CK groups consists of CK1, CK2, CK3, CK4, CK5, CK6, CK7, CK8 and CK9. Epitomics has developed a panel of Cytokeratin Rabbit Monoclonals Antibodies with high affnity and specifcity - all validated for IHC on FFPE human tissues. Visit for complete IHC data and protocol using our Cytokeratin specific antibodies! Cytokeratin RabPAb 100µl, IHC, ICC Human, Rat $250 Cytokeratin RabMAb 100µl, IHC, ICC, IP Human $250 New Cytokeratin RabMAb 100µl, IHC, ICC Human, Rat $250 Cytokeratin RabPAb 100µl, IHC, ICC Human $250 Cytokeratin RabMAb 100µl, IHC, ICC, IP Human $250 Cytokeratin 5 (C-term) RabMAb 100µl, IHC, ICC Human $250 Cytokeratin RabPAb 100µl, FC Human, Mouse $250 Cytokeratin 15 (C-term) RabMAb 100µl, IHC, ICC, FC Human $250 Cytokeratin RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 Cytokeratin 17 (C-term) RabMAb 100µl, IHC, ICC, IP Human $250 Cytokeratin 17 (N-term) RabPAb 100µl, IHC, ICC, FC Human, Rat $250 Cytokeratin RabMAb 100µl, IHC, ICC, FC Human, Mouse, Rat $250 Cytokeratin RabPAb 100µl, IHC, ICC, FC, IP Human $250 Cytokeratin RabPAb 100µl, IHC, ICC, IP Human $250 Cytokeratin RabMAb 100µl, IHC, ICC, FC, IP Human $250 Cytokeratin 19 (C-term) RabMAb 100µl, IHC, ICC, FC, IP Human $250 Cytokeratin RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 D D(1A) dopamine receptor (DRD1) RabMAb 100µl, FC Human, Mouse, Rat $250 D Dab RabMAb 100µl Mouse, Rat $210 Dab RabMAb 100µl, FC, IP Human $250 Dab RabMAb 100µl, ICC, FC, IP Human $250 Dachshund RabMAb 100µl, FC, IP Human, Rat $250 DAP RabMAb 100µl, IHC, ICC, IP Human $250 DAPK2 (N-term) RabMAb 100µl, IHC, FC Human, Mouse, Rat $250 DAPK RabMAb 100µl, FC Human $250 DAPK RabMAb 100µl Human $210 DARPP RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 DARPP-32 (C-term) RabMAb 100µl, IHC, ICC, IP Human, Mouse $250 Daxx RabMAb 100µl, IHC, ICC, FC Human $250 Desmin RabMAb 100µl, IHC Human, Mouse, Rat $250 DIABLO - See Smac DJ RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 DJ RabMAb 100µl, IHC, ICC, FC Human, Mouse, Rat $250 DLC8 (N-term) RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 New DLK RabMAb 100µl, IHC, ICC Human, Mouse, Rat $250 Cytokeratin RabMAb 100µl, IHC, ICC, IP Human $250 Cytokeratin RabMAb 100µl, IHC, ICC, FC, IP Human $250 Cytokeratin RabMAb 100µl, IHC, ICC, FC, IP Human $250 Cytokeratin 7 (C-term) RabMAb 100µl, ICC, FC, IP Human $250 Cytokeratin 7 (N-term) RabPAb 100µl, IHC, ICC, IP Human $250 Cytokeratin RabMAb 100µl, IHC, ICC, FC Human $250 Cytokeratin RabPAb 100µl, IHC, ICC, IP Human $250 Cytokeratin RabMAb 100µl, IHC, ICC, FC, IP Human $250 IHC on human placenta on( A) JAR, (B) SH-SY5Y, (C) NCCIT, (D) A549 Delta-like protein (DLK) is a transmembrane protein characterized by six epidermal growth factor (EGF)-like repeat motifs. As a member related to the Notch/Delta/Serrate ligand family of proteins, it inhibits preadipocyte differentiation. DLK may also have a role in cell differentiation processes such as adipogenesis, hematopoiesis, and neuroendocrine differentiation. Specificity: A synthetic peptide corresponding to residues in human DLK was used as an immunogen. Cytokeratin 8 Phospho (ps23) RabMAb 100µl, IHC, IP Human, Mouse, Rat $285 New DNMT RabMAb 100µl, ICC, FC, IP Human $250 Cytokeratin 8 Phospho (ps73) RabMAb 100µl, IHC, ICC, IP Human, Mouse $285 DNMT3B RabMAb 100µl, ICC Human, Mouse, Rat $250 Cytokeratin 8 Phospho (ps431) RabMAb 100µl, IHC, ICC, IP Human $285 DNA-PK - See PRKDC Cytokeratin RabMAb 100µl, IHC, ICC, IP Human $250 DRAK RabMAb 100µl, ICC, IP Human $250 New Cytokeratin RabMAb 100µl, IHC, ICC Human, Mouse $250 Dsh RabMAb 100µl, IHC, ICC, FC Human, Mouse, Rat $250 New Cytokeratin RabMAb 100µl, IHC, ICC Human $250 Dynamin RabMAb 100µl, IP Human $250 Cytokeratin RabMAb 100µl, IHC, FC, IP Human $250 Dynamin-1 (C-term) RabMAb 100µl, IHC, ICC Human, Mouse, Rat $250 Cytokeratin RabMAb 100µl Human $250 Cytokeratin RabPAb 100µl, IP Human $

15 Dysferlin RabMAb 100µl, FC Human, Mouse $250 E E-Cadherin RabMAb 100µl, IHC, ICC, IP Human $250 E E-Cadherin Phospho (ps838/840) RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $285 New ENTPD RabMAb 100µl Human, Mouse, Rat $250 Endo G (C-term) RabMAb 100µl Human, Mouse, Rat $210 Enolase 2 gamma RabMAb 100µl, IHC, ICC, FC Human, Mouse, Rat $250 eef RabMAb 100µl, IHC, ICC Human, Mouse, Rat $250 eef2 (C-term) RabPAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 eef2 (C-term) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 eef2 Phospho (pt56/58) RabMAb 100µl Human, Mouse, Rat $285 eef-2k RabMAb 100µl, IP Human, Mouse, Rat $250 eef-2k (C-term) RabMAb 100µl, ICC, IP Human, Mouse, Rat $250 EGFR RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 EGFR RabMAb 100µl, ICC, FC Human, Mouse $250 IHC on human brain on (A) fetal brain, (B) SH-SY-5Y, (C) HeLa, (D) Y79 Enolase is a glycolytic enzyme that catalyzes the interconversion of 2-phosphoenolpyruvate to phosphoenolpyruvate in the glycolytic pathway. The functional enzyme is a dimer made up of subunits referred to as alpha, beta, and gamma. The alpha-, or nonneuronal, enolase (ENO1) is a nearly ubiquitous form, found in almost all tissues, and its expression precedes that of the other isoforms in the early stage of embryonic development. The beta-, or muscle-specific, enolase (ENO3) is present in adult skeletal muscle, and the gamma-, or neuron-specific, enolase (ENO2) is the major form found in mature neurons and in cells of neuronal origin. Specificity: A synthetic peptide corresponding to residues in human Enolase 2 gamma was used as an immunogen. EGFR (C-term) RabMAb 100µl, ICC, FC, IP Human $250 EGFR (N-term) RabMAb 100µl, FC Human $250 EGFR (Pan) RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 EGFR Family EphA RabMAb 100µl, IP Human, Mouse, Rat $250 Epithelial Antigen (Ep-CAM) (C-term) RabMAb 100µl, IHC, ICC Human, Mouse, Rat $250 EpoR Phospho (py485) RabMAb 100µl, IP Human $250 ICC on A431 with cat# (Left) IHC on human lymph node metastasis with cat# (Right) Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein receptor tyrosine kinase that, activated by epidermal growth factor, affects cell growth and differentiation. Binding of EGF or TGF alpha to EGFR activates tyrosine kinase activity of the receptor. The carboxy terminal tyrosine residues on EGFR, Tyr 1068, Tyr 1148, and Tyr 1173, are the major sites of autophosphorylation, which occurs as a result of EGF binding. EGFR overexpression is exhibited various cancer (e.g. glioma, colorectal carcinoma, breast carcinoma, head and neck carcinoma). The phosphorylation level of EGFR is considered one of the important predicators for outcome in non-small cell lung cancer therapy. Visit to see full list of EGFR family antibodies. EPS15R RabMAb 100µl, IHC, ICC, FC, IP Human $250 EPS15R RabMAb 100µl, ICC, FC Human, Mouse, Rat $250 Epsin I RabMAb 100µl, ICC Human, Mouse, Rat $250 ER RabMAb 100µl, IHC, IP Human, Mouse $205 ER (Alpha) RabMAb 100µl, IHC, ICC Human, Mouse, Rat $250 ER (Alpha) RabMAb 100µl, IHC Human $250 New ER (Alpha) RabMAb 100µl, IHC, ICC Human $250 EGFR Phospho (pt678) RabMAb 100µl, ICC Human $285 EGFR Phospho (pt693) RabMAb 100µl, ICC, IP Human $285 EGFR Phospho (ps695) RabMAb 100µl, ICC Human $285 EGFR Phospho (py845) RabMAb 100µl, ICC Human $285 ER Phospho (Alpha, ps104/106) RabMAb 100µl, ICC Human $285 ER Phospho (Alpha, ps118) RabMAb 100µl, IHC, ICC Human $285 ER Phospho (Alpha, ps167) RabMAb 100µl Human $285 New ER beta RabMAb 100µl, ICC, IP Human $250 EGFR Phospho (py1068) RabMAb 100µl, IHC, ICC, IP, FC Human $285 EGFR Phospho (ps1070/1071) RabMAb 100µl, ICC, IP Human $285 EGFR Phospho (py1086) RabMAb 100µl, ICC, IP Human, Mouse $285 EGFR Phospho (py1092) RabMAb 100µl, IHC, ICC Human, Mouse $285 EGFR Phospho (py1110) RabMAb 100µl, ICC, IP Human $285 EGFR Phospho (py1173) RabMAb 100µl, IHC, ICC, IP Human $285 eif-2a Phospho (ps51) RabMAb 100µl, IHC, ICC Human, Mouse, Rat $285 eif-4b (C-term) RabMAb 100µl, IHC, ICC, FC Human $250 on (A) MCF-7, (B) HeLa cell lysates ICC on HeLa Estrogen Receptor beta (ER beta) is a nuclear hormone receptor which is highly homologous to ER alpha. It functions as a ligand-activated transcription factor, binding to estrogens and activation expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Studies have shown ER beta play a role in modulation of the effects of ER alpha, possibly by inhibiting the transcription activation of ER alpha. ER beta is expressed in many tissues, including human thymus, spleen, ovary and testis. Specificity: A synthetic peptide corresponding to N-terminus of human ER beta was used as an immunogen. eif-4b Phospho (ps504) RabMAb 100µl Human, Mouse, Rat $285 eif-4e RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 ErbB - See HER eif-4e (C-term) RabMAb 100µl, IHC, FC, IP Human, Mouse, Rat $250 ERCC RabMAb 100µl, FC Human $250 eif-4e Phospho (ps209) RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $285 New ERG RabMAb 100µl, IHC, ICC Human, Rat $250 eif-5a RabPAb 100µl, IHC, ICC, FC Human, Mouse, Rat $250 Erk1 (pt202/py204)/erk2 (pt185/ py187) Phospho RabMAb 100µl, IHC, ICC Human $285 eif-5a RabMAb 100µl, IHC, FC Human, Mouse, Rat $250 Erk1/p44 MAPK (C-term) RabMAb 100µl Human,Mouse, Rat $210 eif-5a (N-term) RabMAb 100µl, IHC, FC, IP Human, Mouse, Rat $250 Elk-1 (C-term) RabMAb 100µl, IHC, ICC, IP Human $250 EMSY RabMAb 100µl, ICC, FC, IP Human, Mouse, Rat $250 EMTK/ITK/TSK (C-term) RabPAb 100µl, IHC Human, Mouse, Rat $250 EMTK/ITK/TSK (C-term) RabMAb 100µl, FC, IP Human $250 EMTK/ITK/TSK (N-term) RabMAb 100µl, IHC, FC, IP Human $250 Erk1/p44 MAPK Phospho (pt202/204) RabMAb 100µl, IP Human, Mouse, Rat $285 Erk2/p42 MAPK (C-term) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 Erk RabMAb 100µl, IHC, FC Human, Mouse, Rat $250 Erk5 (C-term) RabMAb 100µl, ICC, FC, IP Human, Mouse, Rat $250 Estrogen Related Receptor (Alpha) RabMAb 100µl, FC, IP Human, Mouse, Rat $

16 Etk RabMAb 100µl, IP Human, Mouse, Rat $250 New EYA RabMAb 100µl, IP Human $250 Ezh 1/ RabMAb 100µl, ICC, FC, IP Human $250 Ezrin RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 Ezrin RabMAb 100µl, IHC, ICC, FC, IP Human $250 Ezrin RabMAb 100µl, ICC, FC Human, Mouse, Rat $250 Ezrin Phospho (py353) RabMAb 100µl, ICC Human $285 F FABP4 New RabMAb 100µl Human, Mouse, Rat $210 F New FABP RabMAb 100µl, ICC Human $250 Factor VIII Alpha RabMAb 100µl, IHC, IP Human $250 Factor XIII A RabMAb 100µl, IP Human, Rat $250 FADD (N-term) RabMAb 100µl, IHC Human, Mouse $250 New Fibrinogen (Beta chain) RabMAb 100µl, IHC, ICC Human $250 Fibrinogen (Gamma chain) RabMAb 100µl, FC Human $250 New Fibrinogen (Gamma chain) RabMAb 100µl, IHC Human $250 Fibronectin RabMAb 100µl, IHC, IP Human $250 Fibronectin RabMAb 100µl, IHC Human $250 FIH RabMAb 100µl, FC Human, Mouse, Rat $250 FIH RabMAb 100µl, IHC, ICC, FC Human $250 Factor inhibiting HIF-1 (FIH1) is an Fe (II)-dependent hydroxylase enzyme that serves as an oxygen sensor in the hypoxia response pathway. FIH1 binds to HIF-1alpha and inhibits its transactivation function. It also binds to VHL, which too functions as a transcriptional corepressor that inhibits HIF-1alpha transactivation function. In addition, FIH1 regulates the Notch signaling output and plays a role in how Notch signaling modulates the hypoxic response. It negatively regulates Notch activity and accelerates myogenic differentiation. FADD Phospho (ps194) RabMAb 100µl, IP Human $285 FAK RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 ICC on HeLa Specificity: A synthetic peptide corresponding to residues in human FIH1 was used as an immunogen. FAK RabMAb 100µl, IHC, ICC, FC Human, Mouse, Rat $250 FAK Phospho (py397) RabMAb 100µl Human, Rat $285 FAK Phospho (py576) RabMAb 100µl, FC Human, Mouse, Rat $285 FAK Phospho (py576/577) RabMAb 100µl, ICC, FC, IP Human $285 FAK Phospho (py861) RabMAb 100µl Human, Mouse, Rat $285 FAK2 - See Pyk2 FAK2 (C-term) RabMAb 100µl, IP Human, Rat $250 FAK2 (C-term) RabMAb 100µl, IHC, IP Human, Rat $250 FAK2 (N-term) RabMAb 100µl, IHC, ICC, IP Human,Mouse, Rat $250 Fc gamma RIIb (C-term) RabPAb 100µl, ICC, FC Human $250 Fc gamma RIIb (C-term) RabMAb 100µl, IHC, FC, IP Human, Rat $250 Fc gamma RIIb Phospho (py292) RabMAb 100µl, IP Human $285 New FE RabMAb 100µl, IHC, ICC Human $250 on (A) Jurkat, (B) 293, (C) A375 Filamin A (C-term) RabMAb 100µl, IHC, ICC, FC Human, Mouse, Rat $250 Filamin A Phospho (ps1458) RabMAb 100µl, IHC, ICC Human $285 Filamin A Phospho (ps2152) RabMAb 100µl, IHC, ICC Human $285 New FKBP RabMAb 100µl, IHC, FC Human, Mouse, Rat $250 New FKBP RabMAb 100µl, IHC Human, Mouse, Rat $250 FKHR RabMAb 100µl, IHC, ICC Human, Mouse, Rat $250 Flotillin RabMAb 100µl Human. Mouse $210 Flt3-L RabMAb 100µl, IHC. ICC, FC Human $250 Fodrin (Alpha) RabMAb 100µl, IHC, ICC Human, Mouse, Rat $250 New Fodrin (Alpha) RabMAb 100µl, IHC, IP Human, Mouse, Rat $250 New Fodrin (Alpha, Cleaved) RabMAb 100µl, IP Human $250 FOXO3a RabMAb 100µl, IHC. ICC Human $250 FRAP - See mtor IHC on human brain Amyloid beta A4 precursor protein-binding family B member 1 (FE65) is a member of a family of multidomain adaptor proteins (FE65, FE65L1, and FE65L2) that form multiprotein complexes with a range of functions. FE65 is highly expressed in the brain and it has three protein-protein interaction domains: a WW domain and two PID/PTB domains. Specificity: A synthetic peptide corresponding to residues in human FE65 was used as an immunogen. FRIH RabMAb 100µl, ICC Human, Mouse, Rat $250 FRIH RabMAb 100µl, IHC Human $250 FYB RabMAb 100µl, IHC, ICC Human, Mouse $250 FYB RabMAb 100µl, IHC, ICC, FC Human $250 Fyn (p59fyn) RabMAb 100µl, IHC, ICC Human, Mouse, Rat $250 G Gab RabMAb 100µl, ICC Human, Mouse, Rat $250 G on SH-SY5Y Gab RabMAb 100µl, ICC, FC, IP Human, Mouse, Rat $250 Fer RabMAb 100µl, FC, IP Human, Mouse, Rat $250 GABA(B) R RabMAb 100µl, IHC, ICC, FC Human, Mouse, Rat $250 FES RabMAb 100µl, ICC Human $250 GABA(B) R2 Phospho (ps884) RabMAb 100µl, IHC, ICC, IP Human, Mouse $285 Fgr RabMAb 100µl, ICC Human $250 GABA(B) R2 Phospho (ps893) RabMAb 100µl, IHC, ICC Human, Mouse, Rat $285 Fgr RabMAb 100µl, IP Human $250 GAD RabMAb 100µl Human, Mouse, Rat $210 New FGF RabMAb 100µl, FC, IP Human $250 Galectin RabMAb 100µl, IHC, ICC, FC Human $250 FGF Receptor 1 (C-term) RabMAb 100µl Human $210 Galectin RabMAb 100µl, IHC, ICC, FC Human, Rat $250 Fibrinogen (Alpha chain) RabMAb 100µl, IHC, ICC, IP Human, Rat $250 Gamma Synuclein (SR) RabMAb 100µl, IHC, ICC, FC, IP Human, Rat $250 New Fibrinogen (Alpha chain) RabMAb 100µl, FC, IP Human $250 GAP RabMAb 100µl, ICC Human, Mouse, Rat $250 GAP43 (C-term) RabPAb 100µl, IHC, ICC, FC, IP Human, Rat $250 Fibrinogen (Beta chain) RabMAb 100µl, ICC, FC Human, Rat $250 GAP43 (C-term) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 GAPDH RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $

17 Gata RabMAb 100µl, FC Human $250 GCDFP RabMAb 100µl, IHC, ICC, FC Human $250 New GCDFP RabMAb 100µl, IHC, ICC Human $250 GCN2 Phospho (pt667) RabMAb 100µl, IP Human $285 GCN2 Phospho (pt899) RabMAb 100µl Human $285 Gelsolin RabMAb 100µl, IHC Human, Mouse, Rat $250 Gelsolin RabMAb 100µl, IHC, ICC, IP Human $250 GFAP (C-term) RabMAb 100µl, IHC, ICC, IP Human, Rat $250 GFAP (N-term) RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 GFP (N-term) RabMAb 100µl Human $210 New Glucagon RabMAb 100µl, IHC Human $250 New Glucagon RabMAb 100µl, IHC Human, Mouse, Rat $250 GluR RabMAb 100µl, IHC, IP Human $250 GluR1 Phospho (ps845) RabMAb 100µl Human, Mouse, Rat $285 GluR RabMAb 100µl, FC, IP Human, Mouse, Rat $250 GluR2/ RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 GluR RabMAb 100µl, IHC, ICC, IP Human, Mouse $250 Glut RabMAb 100µl, IHC, FC, IP Human, Mouse, Rat $250 Glycodelin - See PAEP Glycogen Synthase RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 Glycogen Synthase (C-term) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 Glycogen Synthase Phospho (ps641) RabMAb 100µl, IHC, ICC, IP Human, Mouse $285 GNB RabMAb 100µl, ICC, FC, IP Human, Mouse, Rat $250 GNB RabMAb 100µl Human $250 GM130 (Golgi Matrix Protein) RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 GM130 (Golgi Matrix Protein) RabMAb 100µl, FC Human $250 GM-CSF (Bioactive) RabMAb 100µl ELISA,, Inhibit Human $245 Left: Recombinant human GM-CSF stimulates the proliferation of the GM-CSF dependent human TF-1 cells in a dose-dependent manner. Right: Inhibition of TF-1 proliferation by anti-human GM-CSF RabMAb. GM-CSF stimulates the growth and differentiates of hematopoietic precursor cells, such as granulocytic and macrophage cells, eosinophils and erythrocytes. Also, it is involved in stimulating mature end cells and as well as antigen-presenting dendritic cells, therefore, increasing these cells functional capacity to combat against infection. GM-CSF is not required for steady state hematopoiesis state, however, it is essential for maintaining the functional activity of certain macrophages (e.g. immune response specific). Specificity: This antibody was selected for its ability to neutralize human GM-CSF s bioactivity. GOS-28 (Golgi SNARE Protein) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 GPR RabMAb 100µl, IHC, IP Human, Mouse, Rat $250 New GPR RabMAb 100µl Human $210 GRB2 (C-term) RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 GRB2 (N-term) RabMAb 100µl, IHC, ICC, FC Human, Mouse, Rat $250 GRK2 (Beta, C-term) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 GRK RabMAb 100µl, FC Human $250 GRP RabMAb 100µl Human, Mouse, Rat $210 GRP1 (C-term) RabPAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 GSK3 (Alpha) RabMAb 100µl, IHC, ICC, IP Human, Rat $250 GSK3 (Alpha, Beta) RabMAb 100µl Human, Mouse, Rat $210 GSK3 (C-term) RabMAb 100µl, IHC, ICC Human, Mouse $250 GSK3 Phospho (Beta, ps9) RabMAb 100µl, IHC, ICC Human $285 GSK3 Phospho (Alpha, Beta, py2169/py279) RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $285 Gstk RabMAb 100µl, IHC, ICC, IP Human $250 Gstk RabMAb 100µl, IHC, ICC, FC, IP Human $250 H Hamartin - See TSC1 H HB9/HBLX RabMAb 100µl, IP Human, Mouse $250 Hck (C-term) RabMAb 100µl, ICC, FC, IP Human $250 Heme Oxygenase 1 (HO-1) RabMAb 100µl, IHC, ICC, IP Human, Mouse $250 Heme Oxygenase 1 (HO-1) RabMAb 100µl, ICC, IP Human, Mouse, Rat $250 Hemoglobin alpha chain RabMAb 100µl, IHC, FC, IP Human, Mouse, Rat $250 HER2 / ErbB RabMAb 100µl, IHC, FC, IP Human $250 HER RabMAb 100µl IHC Human $205 HER2 Phospho (py877) RabMAb 100µl, ICC Human $285 HER2 Phospho (py877) RabMAb 100µl, IHC, ICC Human $285 HER2 Phospho (py1139) RabMAb 100µl, FC, IP Human $285 HER2 Phospho (pt1221 / T1222) RabMAb 100µl Human $285 HER3 (C-term) RabMAb 100µl, IP Human, Rat $250 HER3 Phospho (py1289) RabMAb 100µl, ICC Human $285 HER RabMAb 100µl Human, Mouse, Rat $210 HER4 ( C-term) RabMAb 100µl, ICC, FC, IP Human, Mouse $250 New HER4 Phospho (py1056) RabMAb 100µl Human $285 HER4 Phospho (py1162) RabMAb 100µl, IHC, IP Human $285 HER4 Phospho (py1188) RabMAb 100µl, ICC Human $285 HER4 Phospho (py1258) RabMAb 100µl Human $285 Hex RabMAb 100µl, ICC, FC, IP Human $250 HIAP RabMAb 100µl, IHC, ICC, IP Human, Rat $250 HIF-1 (Alpha) RabMAb 100µl, IHC, ICC Human, Rat $250 New HIPK RabMAb 100µl, ICC,FC, IP Human $250 Histones Left: ICC using H3 on HeLa (cat# ) Middle: ICC using H2B (K5) RabMAb on HeLa (cat# ) Right: IHC using H2B RabMAb on breast carcinoma (cat# ) Changes in chromatin structure play a large role in the regulation of transcription in eukaryotes. The nucleosome is the primary building block of chromatin, and is made up of four core histone proteins (H2A, H2B, H3 and H4). Various post-translational modifications, such as acetylation and methylation, of core histones serve as regulators of gene expression. Complete list of Histone related antibodies available at Histone Deacetylase 2 (C-term) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 Histone Deacetylase 3 (C-term) RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 Histone Deacetylase 3 (N-term) RabMAb 100µl, IHC, ICC Human, Mouse $250 Histone Deacetylase RabMAb 100µl, ICC Human $250 Histone Deacetylase 4 (C-term) RabMAb 100µl, FC, IP Human $250 Histone H2A Acetyl (K5) RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 Histone H2A.x Phospho (ps139) RabMAb 100µl, IHC, ICC Human, Rat $285 Histone H2B RabPAb 100µl, IHC, ICC, IP Human, Rat $

18 Histone H2B RabMAb 100µl, IHC, IP Human, Mouse $250 Histone H2B RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 Histone H2B Acetyl (K12) RabMAb 100µl, IHC, ICC Human $285 Histone H2B Acetyl (K15) RabMAb 100µl, IHC, ICC Human, Mouse, Rat $285 Histone H2B Acetyl (K5) RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $285 Histone H2B Actyl (K20) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $285 Histone H2B Type 1B RabMAb 100µl, IHC, ICC Human $250 Histone H RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 Histone H3 Acetyl (K18) RabMAb 100µl, IHC, ICC Human, Mouse, Rat $285 Histone H3 Acetyl (K56) RabMAb 100µl, IHC, ICC Human, Mouse, Rat $285 Histone H3 Acetyl (K9) RabMAb 100µl, IHC, ICC, IP Human, Mouse $285 Histone H3 Acetyl (K14) RabMAb 100µl, IHC, ICC, IP Human, Rat $285 Histone H3 Dimethyl (K4) RabMAb 100µl, IHC, ICC Human, Rat $285 Histone H3 Dimethyl (K9) RabMAb 100µl, ICC Human, Mouse, Rat $285 Histone H3 Phospho (ps10) RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $285 Histone H3 Phospho (ps28) RabMAb 100µl, IHC, ICC Human, Mouse $285 HSF RabMAb 100µl, IHC, ICC, FC, IP Human $250 HSF1 Phospho (ps303/307) RabMAb 100µl, IHC,ICC Human $285 HSF1 Phospho (ps320) RabMAb 100µl, IHC ICC Human $285 HSF1 Phospho (ps326) RabMAb 100µl, IHC, ICC, IP Human $285 HSF RabMAb 100µl, ICC, FC Human $250 HSF4 (Isoform A) RabMAb 100µl, IHC, ICC Human $250 HSL Phospho (ps855) RabMAb 100µl Human, Mouse $285 HSP RabMAb 100µl, IHC, ICC Human $250 HSP27 Phospho (ps15) RabMAb 100µl, IHC, IP Human $285 HSP27 Phospho (ps78) RabMAb 100µl, IHC, ICC, IP Human $285 HSP27 Phospho (ps82) RabMAb 100µl, IHC, ICC, IP Human, Rat $285 HSP RabPAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 HSP RabMAb 100µl, IHC Human, Mouse, Rat $250 HSP70 (C-term) RabMAb 100µl, IHC, FC, IP Human $250 HSP RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 New HSP90 Alpha RabMAb 100µl, IHC Human, Mouse, Rat $250 Histone H3 Phospho (pt3) RabMAb 100µl, IHC, ICC Human $285 Histone H3.3 Phospho (ps28 & 31) RabMAb 100µl Human $285 Histone H3.3 Phospho (ps31) RabMAb 100µl, IHC, ICC Human, Mouse, Rat $285 Histone H3T Acetyl (K27) RabMAb 100µl, IHC, ICC Human $285 Histone H4 Acetyl (K5) RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $285 Histone H4 Acetyl (K8) RabMAb 100µl, IHC, ICC, IP Human, Mouse $285 HIV-p RabMAb 100µl N/A $210 New HLA-Dra RabMAb 100µl, IHC, ICC, IP Human $250 Human class II major histocompatibility complex (MHC) products are essential initiators of cellular immune responses. Their cell surface expression demonstrates aspects of tissue-restriction, inducibility, differentiation-dependence, and coordinate regulation indicative of complex molecular controls mediated primarily at the level of transcription. HLA-DR alpha is a polymorphic cell surface glycoprotein that is crucial for the cellular interaction in immune response. Class II molecules have limited tissue distribution and are predominantly expressed on B lymphocytes and macrophage and present peptides derived from extracellular proteins to T cells IHC on human breast carcinoma on (A) HeLa, (B) Jurkat, (C) SKBR-3, and (D) K562 Heat shock protein 90 alpha (Hsp90 alpha) is a cytosolic homodimeric molecular chaperone that modulates the stability and/or transport of a diverse set of critical cellular regulatory, metabolism, organization, and signaling proteins. Hsp90 distinguishes itself from other chaperones by having most of its known substrates as signal transduction proteins; e.g. non activated steroid hormone receptors, several proto-oncogenic tyrosine and serine/ threonine kinases, and actin. Specificity: A synthetic peptide corresponding to residues in human Hsp90 Alpha was used as an immunogen. HSP90 Beta RabMAb 100µl, IHC, ICC, IP, FC Human, Mouse $250 htert (C-term) RabMAb 100µl, IHC, ICC, FC Human $250 HtrA RabMAb 100µl, IHC ICC, FC, IP Human, Mouse, Rat $250 IHC on human kidney Specificity: A synthetic peptide corresponding to residues in human HLA-Dra was used as an immunogen. HtrA2 (N-term) RabMAb 100µl, IHC, IP Human, Mouse, Rat $250 Huntingtin Protein (Htt) RabMAb 100µl, IHC, ICC, FC Human, Mouse, Rat $250 HLF RabMAb 100µl Human, Mouse, Rat $210 Hmgb RabMAb 100µl, IHC, FC Human, Mouse, Rat $250 I ICAM RabMAb 100µl, IHC, ICC Human $250 I IDO RabMAb 100µl Human $210 Hmgb RabMAb 100µl, IHC, FC, IP Human, Mouse, Rat $250 IFN alpha R1 (C-term) RabMAb 100µl, FC, IP Human, Mouse, Rat $250 Hmgb RabMAb 100µl, IHC, FC, IP Human, Mouse, Rat $250 IFN gamma RabMAb 100µl Human $210 New HNF4 Alpha RabMAb 100µl, ICC Human $250 IGBP1 - See CD79a New HNF4 Alpha RabMAb 100µl, IHC, ICC, FC, IP Human $250 hnrnp C1/C RabMAb 100µl, IHC, ICC Human, Mouse, Rat $250 IkappaB alpha RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 IkappaB alpha RabMAb 100µl, IHC, ICC, FC Human, Mouse, Rat $250 hnrnp K RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 HNRPUL RabMAb 100µl, IHC, ICC, FC, IP Human $250 HoxB RabMAb 100µl, IHC, ICC, FC, IP Human $250 New IkappaB alpha Phospho (py32) RabMAb 100µl, ICC, IP Human $285 New IkappaB alpha Phospho (py42) RabMAb 100µl, IP Human $285 IKK (Beta) RabMAb 100µl, IHC, FC, IP Human $250 HPK1 (N-term) RabMAb 100µl, IHC, FC Human $250 IKK alpha (N-term) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 H-Ras (C-term) RabMAb 100µl, ICC, IP Human, Mouse, Rat $250 IL-1 (Beta) RabMAb 100µl Human $210 HSD17B1 (C-term) RabMAb 100µl, IHC, ICC, FC, IP Human $250 IL-1 (Beta, C-term) RabMAb 100µl Human $210 HSD17B1 (C-term) RabMAb 100µl, IHC, ICC, FC Human $250 IL-1R RabMAb 100µl, FC, IP Human, Mouse, Rat $250 IL RabMAb 100µl, IHC, ICC Human $250 IL-3R (Beta, C-term) RabMAb 100µl, IHC Human $

19 IL RabMAb 100µl, ICC Human $250 IL-4 (Bioactive) RabMAb 100µl ELISA,, Inhibition Study Human $245 IL RabMAb 100µl Human $210 IL-6 (Bioactive) RabMAb 100µl ELISA,, Inhibit Human $245 IL RabMAb 100µl Human $250 IL RabMAb 100µl Human, Mouse, Rat $210 New IL RabMAb 100µl, ICC Human $250 New IL RabMAb 100µl, ICC Human $250 IL RabMAb 100µl Human $210 IL RabMAb 100µl Human $210 IL-15 (BioActive) RabMAb 100µl ELISA, Inhibition Study Left: Recombinant human IL-15 stimulates the proliferation of human CTLL-2 cells in a dose-dependent manner Right: Inhibition of CTLL-2 proliferation by anti-human IL-15 RabMAb Human $245 IL-15 regulates T and natural killer cell activation and proliferation, causes B cell proliferation and differentiation and stimulates chemotaxis of T cells. High concentrations of IL-15 have been observed in inflamed joints of rheumatoid arthritis patients, suggesting a role for IL-15 in inflammatory diseases where there is recruitment of leukocytes. Specificity: This antibody was selected for its ability to neutralize human IL-15 bioactivity. The crossreactivity with IL-15 of other species has not been tested. IL RabMAb 100µl Human, Mouse $210 IL-18BP RabMAb 100µl, IHC, FC Human, Rat $250 ILF RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse $250 ILF RabMAb 100µl, IHC, ICC, IP Human $250 ILK RabPAb 100µl, IP Human, Mouse, Rat $250 ILK RabMAb 100µl, IHC, ICC Human, Mouse, Rat $250 ILK RabMAb 100µl, ICC, FC Human, Mouse, Rat $250 Indian Hedgehog (IHH) RabMAb 100µl, IHC, IP Human, Mouse, Rat $250 Inhibin Alpha Chain RabMAb 100µl, FC Human, Mouse, Rat $250 INK4a - See p16 INP4A RabMAb 100µl Human, Mouse, Rat $210 INP4B RabMAb 100µl, FC Human, Mouse, Rat $250 New Insulin RabMAb 100µl, IHC Human $250 Integrin Beta RabMAb 100µl, IHC, ICC Human $250 Integrin Beta 1 Phospho (py783) RabMAb 100µl Human $285 Integrin Beta RabMAb 100µl, IP Human, Mouse, Rat $250 Integrin beta-3 (CD61 antigen, GP IIIa) is a member of the integrin family of integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta-3 forms a Ca2+-dependent heterodimer complex with the GP IIb chain in platelet. The cytoplasmic domain of Integrin beta-3 has be suggested to have a key role in cell adhesion. Following activation integrin beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surfaces. Specificity: A synthetic peptide corresponding to residues in human Integrin beta-3 was used as an immunogen. (A) THP-1 treated with TPA, (B) HUVEC, (C) human spleen, (D) human plasma Integrin Beta 3A RabMAb 100µl, IHC Human, Mouse, Rat $285 IPP RabMAb 100µl, IHC, FC, IP Human, Mouse, Rat $250 IRAK-3 (C-term) RabMAb 100µl, IP Human $250 IRAK-4 (N-term) RabMAb 100µl, ICC Human $250 IRF-3 Phospho (ps386) RabMAb 100µl, ICC Human $285 IRF-3 (N-term) RabMAb 100µl, IHC, FC Human, Mouse $250 IRF-3 (C-term) RabMAb 100µl, IHC, FC, IP Human $250 IRR alpha subunit RabMAb 100µl, IHC Human, Mouse, Rat $250 IRS RabMAb 100µl, IHC, ICC, IP Human $250 IRS-1 Phospho (py896) RabMAb 100µl Human, Mouse, Rat $285 IRS RabMAb 100µl, IHC, ICC, IP Human $250 IRS-2 (Pan) RabMAb 100µl, IHC, IP Human $250 IRS-4 (C-term) RabMAb 100µl, IHC, FC, IP Human $250 ISG RabMAb 100µl, ICC Human $250 New ISG RabMAb 100µl, ICC Human $250 ITAM - See CD11b ITAX (C-term) RabMAb 100µl, IHC, ICC, IP Human $250 ITGB1 - See LFA-1a ITGB2 - See LFA-β2 ITK - See EMTK J JAK2 New RabMAb 100µl, ICC Human, Mouse, Rat $250 J JAK2 Phospho (py1007/1008) RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $285 New JAK3 (N-term) RabMAb 100µl, ICC Human, Mouse, Rat $250 Insulin is a hormone that regulates glucose homeostasis. It increases cell permeability to monosaccharides, amino acids and fatty acids, and it accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. Insulin is a heterodimer of a B chain and an A chain linked by two disulfide bonds. It is synthesized in the beta cell of the pancreas as the precursor, proinsulin, where the carboxyl terminus of the B-chain is connected to the amino terminus of the A-chain by a C-peptide. JAK3 (C-term) RabMAb 100µl, FC, IP Human $250 JAM1 (N-term) RabMAb 100µl, IHC Human, Mouse, Rat $250 JNK1/JNK2/JNK3 Phospho (py185/ py223) RabMAb 100µl, IP Human, Mouse, Rat $285 IHC on human pancreas Specificity: A synthetic peptide corresponding to residues in human Insulin was used as an immunogen.. New JNK RabMAb 100µl, IP Human, Mouse, Rat $250 JNK RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 K KDR - See VEGFR2 K on fetal pancreas lysate Keratin - See Cytokeratin INSR / IGF-R Phospho (py1185) RabMAb 100µl, ICC, IP Human $285 Integrin Alpha Phospho (ps1027) RabMAb 100µl Human, Mouse, Rat $285 Ki RabMAb 100µl IHC Human, Mouse, Rat $205 Ki RabMAb 100µl IHC, ICC, FC Human $250 Integrin Beta RabMAb 100µl, IHC, FC Human, Mouse, Rat $

20 Ki RabMAb 100µl, IHC, ICC, FC Human $250 Left: IHC on human tonsil Middle: IHC on human colonic adenocarcinoma Right: ICC on HeLa Ki-67 is expressed in all proliferating cells which are in the active phases of the cell cycle (late G1, S, G2, and mitosis), but absent in resting cells. Due to the fact that Ki-67 can be used to determine the growth fraction (the proportion of the cells committed to the cell cycle), it is consider an important marker in human tumor diagnostics and prognostics Specificity: A synthetic peptide corresponding to residues in human Ki-67 was used as an immunogen. KID RabMAb 100µl, FC, IP Human $250 KID Phospho (ps427) RabMAb 100µl Human $285 Kip1 - See p27 Kip RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 KSR RabMAb 100µl, IHC, ICC Human, Mouse $250 KSR1 Phospho (ps404) RabMAb 100µl, ICC Human $285 New Ku RabMAb 100µl, IHC, ICC, FC, IP Human $250 Ku RabMAb 100µl, IHC, ICC, FC Human $250 Ku RabMAb 100µl, IHC, ICC, IP Human $250 Kv RabMAb 100µl, IHC, FC Human $250 L LAT RabMAb 100µl, IHC, FC, IP Human $250 L LAT Phospho (py191) RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $285 LAT Phospho (py200) RabMAb 100µl, ICC Human $285 Lyn Phospho (py507) RabMAb 100µl, IHC, IP Human, Mouse, Rat $285 New Lysozyme C RabMAb 100µl, ICC, IP Human $250 M MAG RabMAb 100µl, FC, IP Human, Mouse, Rat $250 M MALT1 (N-term) RabMAb 100µl, FC, IP Human $250 New MAP2 Phospho (ps136) RabMAb 100µl, IHC, IP Human, Mouse, Rat $285 MAPILC3A RabMAb 100µl, FC Human, Mouse, Rat $250 MAPILC3A (C-term) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 MAPILC3A (N-term) RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 MAPKAP Kinase RabMAb 100µl, IP Human, Mouse, Rat $250 MAPKAP Kinase-2 Phospho (pt334) RabMAb 100µl, IHC, ICC Human $285 MARCKS RabMAb 100µl, IHC, ICC, FC Human $250 MARCKS Phospho (ps159/s163) RabMAb 100µl, IP Human, Mouse, Rat $285 New MARCO RabMAb 100µl Human $250 MARK RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse $250 MART-1 (N-term) RabMAb 100µl, IHC Human $250 MBD RabMAb 100µl, IHC, ICC, IP Human $250 MBP RabMAb 100µl, ICC, FC, IP Human, Mouse, Rat $250 Mcl RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse $250 New MCM RabMAb 100µl Human $250 New MCM2 Phospho (ps27) RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $285 LCAT RabMAb 100µl, IHC, ICC, FC, IP Human $250 LCK RabMAb 100µl, IHC, ICC, FC, IP Human $250 LCK Phospho (py505) RabMAb 100µl Human, Mouse $285 LDH-A RabPAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 LDH-A RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 LDH-A (Muscle subunit) RabMAb 100µl, IHC, ICC, FC Human, Mouse, Rat $250 LDH-B RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 ICC on HeLa Minichromosome maintenance protein 2 (MCM2) is a member of the MCM family that regulates mammalian DNA replication. This family is composed of six related subunits, called the hexameric MCM2-7 complex, that are conserved in all eukaryotes. It functions as a replicative helicase, the molecular motor that both unwinds duplex DNA and powers fork progression during DNA replication. Ser27, Ser41, and Ser139 are suggested to be Cdc7/Dbf4 phosphorylation sites in MCM2. Specificity: A phospho specific peptide corresponding to residues surrounding serine 27 of human MCM2 was used as an immunogen. LDH-B RabMAb 100µl, IHC, ICC, FC, IP Human $250 on HeLa, (A) untreated or (B) treated with AP LDH-C RabMAb 100µl, IHC, FC Human $250 LDH-C (N-term) RabMAb 100µl Human $210 LDL Receptor (C-term) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 MCM RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse $250 MCM RabMAb 100µl, IHC, ICC, FC, IP Human $250 MCM RabPAb 100µl, IP Human, Rat $250 LEF RabMAb 100µl, IHC, ICC, FC Human $250 MCM RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 LEF RabMAb 100µl, IHC, ICC Human $250 LFA-1a - See CD11a LFA-beta2 / ITGB RabMAb 100µl, IP Human $250 LFA-beta2 / ITGB2 Phospho (ps745) RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $285 LIMK2 (C-term) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 LIMS RabMAb 100µl, FC Human, Mouse, Rat $250 New Lipin RabMAb 100µl, IHC, ICC, FC, IP Human $250 LMO RabMAb 100µl, FC, IP Human $250 New LRP RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 LRP6 Phospho (ps1490) RabMAb 100µl, ICC Human $285 LRPAP RabMAb 100µl, IHC FC Human, Mouse, Rat $250 Lyn RabMAb 100µl, IP Human $250 Lyn Phospho (py396) RabMAb 100µl, FC Human $285 MCM RabMAb 100µl, ICC, FC Human $250 M-CSF RabMAb 100µl, IHC, ICC, IP Human $250 MEF2A RabMAb 100µl, IHC, ICC, FC Human, Mouse, Rat $250 MEK1 (C-term) RabMAb 100µl, IHC, ICC, FC, IP Human, Rat $250 MEK1 (N-term) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 MEK1 Phospho (pt286) RabMAb 100µl, IP Human $285 MEK1 Phospho (pt292) RabMAb 100µl Human $285 New MEK1 Phospho (ps298) RabMAb 100µl, IHC, ICC Human, Mouse, Rat $285 MEK1/MEK2 Phospho (ps218/222) RabMAb 100µl, IHC, ICC, IP Human $285 MEK2 (N-term) RabMAb 100µl, IHC, ICC, FC, IP Human, Rat $250 MEKK RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 MEKK2 (C-term) RabMAb 100µl, IHC, ICC, FC, IP Human $250 MEKK3 (C-term) RabMAb 100µl, IHC, ICC, FC, IP Human $250 MEKK3 (N-term) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $

21 MEKK RabMAb 100µl, IHC, ICC, FC Human $250 MEKK5 (N-term) RabMAb 100µl, IHC, ICC, FC Human, Mouse $250 New Menin RabMAb 100µl, IHC, ICC, IP Human $250 New Mesothelin RabMAb 100µl Human $210 MerTK RabMAb 100µl, IHC, FC, IP Human, Mouse $250 Met (N-term) RabMAb 100µl, IHC, ICC Human $250 Met Phospho (py1349) RabMAb 100µl, IHC, ICC, IP Human $285 Met is a receptor protein-tyrosine kinase (RPTK) for hepatocyte growth factor (HGF), which is a multifunctional cytokine controlling cell growth, morphogenesis, and motility. Met overexpression has been identified in a variety of human cancers. Met-mediated invasive growth requires autophosphorylation of the receptor on tyrosines located in the kinase activation loop (Tyr(1234)-Tyr(1235)) and in the tail (Tyr(1349)-Tyr(1356)). Specificity: A phospho specific peptide corresponding to residues surrounding tyrosine 1349 of human Met was used as an immunogen. This antibody detects Met phosphorylated at tyrosine on A431 cell lysate A) untreated and B) treated with AP mglur RabMAb 100µl, IHC, ICC, FC Human, Mouse, Rat $250 MHC class RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 MHC class RabMAb 100µl, IHC, ICC, FC Human $250 Midkine (C-term) RabMAb 100µl, IHC, ICC, IP Human $250 MMP RabMAb 100µl, IHC, ICC Human, Mouse, Rat $250 MMP RabMAb 100µl, IHC, ICC Human $250 MMP RabMAb 100µl, IHC, ICC, IP Human, Rat $250 MMP RabMAb 100µl, IHC, ICC, FC Human $250 MMP-9 (Propeptide) RabMAb 100µl, IHC, FC Human $250 MMP RabMAb 100µl, IHC, ICC Human, Mouse, Rat $250 MMP-12 (C-term) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 MMP RabMAb 100µl Human, Mouse $210 MMP RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 MMP RabMAb 100µl, IHC, ICC Human, Mouse, Rat $250 MMP RabMAb 100µl, ICC Human, Mouse, Rat $250 MMP RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 MMP RabMAb 100µl, FC Human, Mouse, Rat $250 Mo RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 New Mo RabMAb 100µl Human, Mouse, Rat $210 Moesin RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 New MRP8 / S100A RabMAb 100µl, IHC, ICC, IP Human, Mouse $250 MIP-1 (Beta, C-term) RabMAb 100µl Human $210 MIP-1 (Beta, C-term) RabMAb 100µl Human $210 MKK3 (N-term) RabMAb 100µl, FC, IP Human $250 MKK RabMAb 100µl, IHC, ICC, IP Human, Rat $250 MKK4 (C-term) RabMAb 100µl, IHC, FC, IP Human, Mouse, Rat $250 MKK RabMAb 100µl, ICC Human $250 MKK6 (C-term) RabMAb 100µl, IHC Human, Mouse, Rat $250 MKK6 (N-term) RabMAb 100µl, IP Human, Mouse, Rat $250 MKK7 (C-term) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 MKP RabMAb 100µl, IHC, FC, IP Human, Mouse, Rat $250 MLCK RabMAb 100µl, IHC, ICC, FC Human, Mouse, Rat $250 New MLH RabMAb 100µl, IHC, FC, IP Human, Mouse, Rat $250 MLK-3 (C-term) RabMAb 100µl, ICC, FC Human, Mouse $250 MMP Family Sampler Kit RabMAb 40µl per vial, IHC, ICC, FC, IP Human, Mouse, Rat $595 Left: IHC using MMP-8 on human placenta (cat# ) Right: ICC using MMP-2 on HeLa cells (cat# ) Matrix Metalloproteases (MMPs) are a family of 25 endoproteases expressed in mammals known to degrade extracellular matrix and basement membrane components. MMPs are expressed as inactive zymogens, and are secreted from many connective tissues and pro-inflammatory cells. MMPs have been shown to be highly connected with a variety of diseases, including arthritis, inflammation, cancer, angiogenesis, atherosclerosis, cardiac diseases, stroke, ocular diseases, gastrointestinal diseases, and oral diseases. Kit Description: A sampler kit containing Rabbit Monoclonal antibodies for 10 proteins of the MMPs family (MMP 1, 2, 3, 9, 11, 12, 13, 14, 17, and 21). MMP RabMAb 100µl, IHC, ICC, FC, IP Human $250 MMP RabMAb 100µl, IP Human $250 MMP RabPAb 100µl, IHC, ICC, FC, IP Human $250 MMP RabMAb 100µl Human, Mouse, Rat $210 MMP-2 (Propeptide) RabMAb 100µl Human $210 New MMP RabMAb 100µl, FC Human $250 on (A) human spleen, (B) PMBC, (C) HL 60 IHC on human cervical carcinoma MRP8/S100A8 and MRP14/S100A9 are members of the S100 family proteins containing two EF-hand calcium-binding motifs. By a Ca2+ dependent manner S100A8/A9 forms Calprotectin, a heterodimeric inflammatory mediator of inflammation found in the cytoplasm of neutrophils and expressed on the membrane of monocytes. In cancer, MRP8/S100A8 has been linked inflammation-associated cancer and a therapeutic target for breast cancer. S100A8 is expressed myeloid differentiation, in chronic inflammations, and expressed constitutively or induced in epithelial cells during dermatose. Elevated serum level of S100A8 has been linked to various inflammatory disorders including cystic fibrosis, rheumatoid arthritis, and chronic bronchitis Specificity: A synthetic peptide corresponding to N-terminal region of human MRP8 / S100A8 was used as an immunogen. New MRP14 / S100A RabMAb 100µl, IHC, ICC Human $250 New MRP14 / S100A RabMAb 100µl, IHC Human $250 MP1 (C-term) RabMAb 100µl, IHC, ICC, IP Human $250 New MSH RabMAb 100µl, IHC, ICC, FC Human $250 New MSH RabMAb 100µl, ICC, IP Human $250 New MSH RabMAb 100µl, IHC, ICC, IP Human, Mouse $250 MSK1 Phospho (ps360) RabMAb 100µl, ICC, IP Human, Mouse, Rat $285 MSK1 Phospho (ps376) RabMAb 100µl, IHC, ICC, IP Human $285 Mst RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 Mst1 (pt183)/mst2 (pt180) Phospho RabMAb 100µl Human $285 Mst RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 Mst RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 Mst RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 Mst4 (pt178)/mst3 (pt190)/stk25 (pt174) Phospho RabMAb 100µl, ICC Human $285 mtor RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 Mu type Opioid Receptor RabMAb 100µl, IHC, ICC Human, Mouse, Rat $250 New MUC RabMAb 100µl, IHC, ICC, FC, IP Human $250 MUC1 isoform RabMAb 100µl, IHC, FC, IP Human, Mouse, Rat $250 Musashi RabMAb 100µl, IHC, ICC, FC, IP Human, Rat $250 Musashi RabMAb 100µl, IHC, IP Human, Mouse, Rat $

22 Myoglobin RabMAb 100µl, IHC, IP Human, Mouse, Rat $250 New Myoglobin RabMAb 100µl Human $210 New Myosin Light Chain RabMAb 100µl, IHC, IP Human, Mouse, Rat $250 Myosin RLC (N-term) RabPAb 100µl, ICC, IP Human $250 Myosin RLC (N-term) RabMAb 100µl, ICC, FC Human $250 MYPT1 (N-term) RabMAb 100µl, ICC Human $250 MYPT1/MYPT2 (C-term) RabMAb 100µl, ICC, IP, FC Human, Mouse, Rat $250 N Na+/K+ ATPase α RabMAb 100µl, IHC, FC Human, Mouse, Rat $250 N NAK/TBK1 (N-term) RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 N-Cadherin RabMAb 100µl Human, Mouse, Rat $210 N-Cadherin (C-term) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 NCAM RabMAb 100µl, IHC, ICC, FC, IP Human $250 NCAM RabMAb 100µl, ICC, FC, IP Human $250 Nck RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 NDUFAF RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 ICC on HeLa IHC on human liver NDUFAF1 (CIA30) is a chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex 1). Complex I is the largest multiprotein enzyme located in the inner mitochondrial membrane that catalyzes the transfer of electrons from NADH to coenzyme Q (CoQ). NDUFAF1 expression is ubiquitous with a slightly higher expression in various heart tissues, kidney, lung and liver. Specificity: A synthetic peptide corresponding to residues at the C terminus of human NDUFAF1 was used as an immunogen. NDUFAF RabMAb 100µl, IHC, ICC, FC, IP Human $250 NEDD8 (N-term) RabMAb 100µl, IHC, ICC, IP Human $250 New NEK RabMAb 100µl Human $210 Nephrin Phospho (py1176/1193) RabMAb 100µl, IP Human, Mouse $285 Nephrin Phospho (py1217) RabMAb 100µl, IP Human, Mouse $285 Neurofilament RabMAb 100µl, IHC, ICC, FC, IP Human, Rat $250 Neurofilament RabMAb 100µl, IHC, ICC Human, Rat $250 Neurofilament RabPAb 100µl, FC, IP Human, Mouse, Rat $250 Neurofilament L (C-term) RabMAb 100µl, FC, IP Human, Mouse, Rat $250 New Neurofilament M RabMAb 100µl, IHC, ICC, IP Human $250 NF-kB p105/p RabMAb 100µl, IHC, ICC, FC Human, Mouse, Rat $250 NGF (Beta) RabMAb 100µl, IHC, ICC Human, Mouse, Rat $250 NGF (Beta, Precursor) RabMAb 100µl, ICC, FC, IP Human, Mouse, Rat $250 NGF Receptor RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 Nibrin RabMAb 100µl, IHC, ICC, IP Human, Mouse $250 Nibrin Phospho (ps343) RabMAb 100µl, ICC, IP Human $285 Nicastrin RabMAb 100µl, FC, IP Human, Mouse, Rat $250 Nm23-H1 (NDPK-A) RabMAb 100µl, IHC, ICC Human $250 NMDAR2B Phospho (ps1303) RabMAb 100µl Human, Mouse $285 nnos RabMAb 100µl, IHC, IP, FC Human, Mouse, Rat $250 Nodal RabMAb 100µl, FC Human, Mouse $250 NOG RabMAb 100µl, IHC, FC, IP Human $250 Noggin RabPAb 100µl, FC, IP Human $250 NOTCH RabMAb 100µl, IHC, ICC Human, Mouse $250 NPM (N-term) RabMAb 100µl, IHC, FC, IP Human $250 NPM Phospho (pt199) RabMAb 100µl, IHC, ICC, IP Human $285 NQO1 (C-term) RabMAb 100µl, IP Human $250 NQO1 (N-term) RabMAb 100µl, IHC, ICC, IP Human, Mouse $250 Nrf RabMAb 100µl, IHC, ICC, IP Human $250 Nrf2 Phospho (ps40) RabMAb 100µl, IHC, ICC, IP Human $285 Nur RabMAb 100µl, FC Human $250 O OCA-B RabMAb 100µl, IHC, ICC Human $250 O New OCA-B RabMAb 100µl Human $250 Oct RabPAb 100µl, IHC, FC Human $250 Oct RabMAb 100µl, IP Human $250 Oct RabMAb 100µl, IHC, ICC, FC Human $250 New Oct RabMAb 100µl, IHC, FC, IP Human $250 Octamer transcription factor-4 (Oct-4) is a homeodomain transcription factor in the POU transcription factor family that specifically binds to the octamer motif (5 -ATTTCAT-3 ) (1). It is critical for early embryogenesis and for embryonic stem cell pluripotency, expressed mainly in the developing brain. OCT4 is a master regulator that affects the fate of pluripotent stem cells and germ cell precursors. Specificity: A synthetic peptide corresponding to residues in human Oct-4 was used as an immunogen Neuofilaments (NF) are members of the intermediate filament protein family also known as 10nm filaments. These neuron-specific filaments are the major constituents of the axonal cytoskeleton. NFs are composed of three major proteins; NF-H, NF-M and NF-L and the ratio of each protein changes during neuronal development. NF-H is the heavy molecular weight protein (200 kda), NF-M the medium (160 kda) and NF-L the light protein (68kDa). IHC ovarian dysgerminom Op18 Phospho (ps24) RabMAb 100µl Human, Mouse, Rat $285 New OTX RabMAb 100µl Human $210 ICC on SH-SY-5Y IHC on normal human brain Specificity: A synthetic peptide corresponding to residues in human Neurofilament M was used as an immunogen. New OTX RabMAb 100µl, IHC Human $250 OX40L RabMAb 100µl Human $210 Neurofilament M Phospho (ps614/619) RabMAb 100µl, IP Human $285 Neuropilin RabMAb 100µl, IHC, FC, IP Human, Mouse, Rat $250 New NFAT RabMAb 100µl Human $210 NF-kB p RabMAb 100µl, IHC, ICC, FC, IP Human $250 NF-kB p RabMAb 100µl, ICC, FC Human $250 NF-kB p65 Phospho (ps536) RabMAb 100µl, IP Human $285 OX RabMAb 100µl Human $210 P p RabMAb 100µl, FC, IP Human $250 P p RabMAb 100µl, IHC, ICC, FC Human $250 p16-arc (N-term) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 New p120 Catenin RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 p190-b RhoGAP RabMAb 100µl, IHC, FC, IP Human, Mouse, Rat $250 p RabMAb 100µl, ICC Human $

23 p RabMAb 100µl, FC, IP Human, Mouse, Rat $250 p21 Phospho (ps145) RabMAb 100µl, IHC, ICC Human, Mouse, Rat $285 IHC on human gastric carcinoma p21 binds to and inhibits CDK activity, preventing phosphorylation of critical CDK substrates and blocking cell cycle progression. p21 is suggested to possibly be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Phosphorylation of Threonine 144 by Akt or of Serine 145 by PKC impairs p21 binding to PCNA. Specificity: A phospho-specific peptide corresponding to residues surrounding Serine 145 of human p21 was used as an immunogen. on 293T. Cells were either (A) untreated (B) treated with LP New p RabMAb 100µl, IHC Rat $250 New p RabMAb 100µl Human $210 p27 (C-term) RabMAb 100µl, IHC, ICC, FC, IP Human, Rat $250 p27 Phospho (ps10) RabMAb 100µl, IHC, IP Human, Mouse, Rat $285 New P2Y RabMAb 100µl, IHC, ICC, IP Human $250 p38 - See Crk p38 MAPK RabMAb 100µl, IHC, ICC Human, Mouse, Rat $250 p38 MAPK Phospho (pt180/py182) RabMAb 100µl, ICC, IP Human, Mouse, Rat $285 p RabMAb 100µl, IHC, ICC, FC, IP Human $250 p44 MAPK (N-term) RabMAb 100µl, IHC, ICC, IP, FC Human, Mouse, Rat $250 p RabMAb 100µl, IHC, ICC Human, Rat $250 p53 (C-term) RabMAb 100µl, ICC, IP, FC Human $250 p53 (N-term) RabMAb 100µl, IHC, ICC, IP Human, Rat $250 p53 Acetyl (K373) RabMAb 100µl, IHC, ICC Human $285 p53 Acetyl (K382) RabMAb 100µl, ICC Human $285 p53 Phospho (ps6) RabMAb 100µl, IHC, ICC, IP Human $285 p53 Phospho (ps9) RabMAb 100µl Human $285 p53 Phospho (ps33) RabMAb 100µl, ICC Human $285 p53 Phospho (ps46) RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $285 p53 acts as both a tumor-suppressor and transcription factor that, upon activation by DNA damage and other cellular stress signals, leads to the transcription of genes triggering cell-cycle arrest, apoptosis, and DNA repair. p53 is frequently mutated or inactivated in about 60% of cancers. Phosphorylation on serine 46 has been implicated as a mediator in apoptosis induced by DNA-damage p80 - See Alk p95 NBS1 Phospho (ps432) RabMAb 100µl, IHC, ICC Human $285 p RabMAb 100µl, IP Human, Mouse, Rat $285 p120 Catenin RabMAb 100µl, IHC, ICC, FC, IP Human $250 p120 Catenin Phospho (py96) RabMAb 100µl Human $285 p120 Catenin Phospho (py228) RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $285 p120 Catenin Phospho (py291) RabMAb 100µl Human $285 p120 Catenin Phospho (pt268) RabMAb 100µl, IHC, ICC Human $285 p120 Catenin Phospho (pt310) RabMAb 100µl, IHC, IP Human, Mouse, Rat $285 p120 Catenin Phospho (pt916) RabMAb 100µl, IHC, ICC Human $285 p130 - See Rb2 p130 See Rb2 New p130cas Phospho (py410) RabMAb 100µl, IP Human $285 Breast cancer anti-estrogen resistance protein 1 (p130cas) is a docking protein that plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (1). It has defined function in cardiovascular development, actin filament assembly and Src-induced transformation (2). p130cas is highly phosphorylated at tyrosines during transformation by v-src, as well as by v-crk, forming stable complexes with these oncoproteins. Specificity: A synthetic peptide corresponding to residues surrounding Tyrosine 410 of human p130cas was used as an immunogen. on HeLa cell lysate A) untreated and B) treated with pervanadate PABP RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse $250 PABP RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse $250 PAEP RabMAb 100µl, IHC Human, Mouse, Rat $250 PAK RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 PAK1 (N-term) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 PAK1 Phospho (ps20) RabMAb 100µl, IP Human $285 PAK RabMAb 100µl, IHC, ICC, FC Human, Mouse, Rat $250 PAK2 Phospho (ps20) RabMAb 100µl, ICC Human $285 PAK3 (N-term) RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 PAK4 (N-term) RabPAb 100µl Human, Mouse, Rat $210 New PAK4 (C-term) RabMAb 100µl, IP Human, Mouse $250 IHC on ovarian adenocarcinoma Specificity: A synthetic phospho-peptide corresponding to residues surrounding Serine 46 of human p53. on HepG2 cells lysate. Cells were either (A) untreated (B) treated with etopside New PAR RabMAb 100µl, IP Human, Mouse $250 Parkin RabMAb 100µl, IHC, ICC, FC Human, Mouse, Rat $250 PARP-1 (Cleaved p25) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse $250 p53 Phospho (ps392) RabMAb 100µl, IHC, ICC, IP Human, Rat $285 PARP-1 (Cleaved p85) RabMAb 100µl, ICC, IP, FC Human, Rat $250 p53 Phospho (ps392) RabMAb 100µl, IHC, ICC, IP Human $285 PARP-1 (p116) RabMAb 100µl, IP Human $250 p56 - See Lck PARP-1 (p116/p25) RabMAb 100µl, IHC, ICC, FC Human, Rat $250 p RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 PARP-1 (p116/p85) RabMAb 100µl Human $210 New p RabMAb 100µl Human $210 p RabMAb 100µl Human $210 Parvin Phospho (ps8) RabMAb 100µl, ICC Human, Mouse, Rat $285 PAX RabMAb 100µl, IHC, FC Human, Mouse $250 p63 / p73l (C-term) RabMAb 100µl, ICC, IP Human $250 New PAX RabMAb 100µl, ICC Human $250 p70 S6 Kinase (N-term) RabMAb 100µl, IHC, FC, IP Human, Mouse, Rat $250 PAX RabMAb 100µl Human $250 p70 S6 Kinase Phospho (pt389) RabMAb 100µl, IHC, IP Human, Mouse $285 Paxillin (N-term) RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 p70 S6 Kinase Phospho (pt421/ps424) RabMAb 100µl, IP Human $285 p RabMAb 100µl, IHC. ICC, IP Human, Mouse, Rat $250 Paxillin Phospho (py31) RabMAb 100µl, IHC, ICC, IP Human, Rat $285 Paxillin Phospho (py181) RabMAb 100µl, IHC, ICC, IP Human $

24 PBK RabMAb 100µl, IP Human $250 PBK (C-term) RabMAb 100µl, IHC, ICC, FC, IP Human $250 New PCNA RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 PKA RIIb RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 PKA RIIb RabMAb 100µl, IHC, ICC, FC Human, Mouse, Rat $250 PKA RIIb Phospho (ps114) RabMAb 100µl, ICC Human, Mouse $285 Left: ICC on HeLa Middle: IHC on human tonsil Right: on (A) HeLa (B) HepG2 (C) 293T, (D) A431 PCNA is a DNA polymerase accessory factor that is required for DNA replication during S phase of the cell cycle and for resynthesis during nucleotide excision repair of damaged DNA. PCNA acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Specificity: A synthetic peptide corresponding to residues in human PCNA was used as an immunogen. PKC Phospho (Beta II, ps660) RabMAb 100µl, IHC, ICC Human, Mouse, Rat $285 PKC (Alpha) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 PKC (Alpha, C-term) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 PKC (Beta II) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 PKC (Delta) RabMAb 100µl, IHC, ICC, FC Human $250 New PKC (Gamma) RabMAb 100µl Human, Mouse, Rat $210 PKC (Mu) RabMAb 100µl Human, Mouse, Rat $210 New PCNA RabMAb 100µl, IHC, FC Human $250 PKC (Theta) RabMAb 100µl Human, Mouse, Rat $210 PDCD RabMAb 100µl, IHC, ICC, FC Human, Mouse $250 PKC Phospho (Alpha, pt497) RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 PDCD RabMAb 100µl, IHC, ICC, FC, IP Human $250 PDCD RabMAb 100µl Human $250 PDGF Receptor (Beta, C-term) RabMAb 100µl, IHC, ICC, IP Human, Mouse $250 PDGF Receptor Phospho (Beta, py1009) PDGF Receptor Phospho (Beta, py740) RabMAb 100µl Mouse $ RabMAb 100µl, ICC Mouse $285 ICC on HeLa cell lysate.(left) IHC on human kidney (Right) Activation of PKC plays a crucial role in tranducing signals for a variety of cellular responses, including tumor proliferation. PKC isoforms have been classified into three groups: classical, novel, and atypical. Members of these three PKC groups contain an autoinhibitory domain that binds to the substrate binding site in the catalytic domain, preventing its activation in the absence of cofactors or activators. The activity of PKC is under the control of three distinct phosphorylation events, including that of the Thr641 autophosphorylation site. Specificity: A phospho specific peptide corresponding to residues surrounding threonine 497 of human PKC alpha was used as an immunogen. PDGF Receptor Phospho (Beta, py857) RabMAb 100µl Mouse $285 PDK RabMAb 100µl, IHC, ICC Human, Mouse, Rat $250 PDK RabMAb 100µl, IHC Human, Mouse $250 PDK RabMAb 100µl, IHC, ICC, FC Human $250 PDK RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 PDZK RabMAb 100µl, IHC, ICC, FC, IP Human $250 PDZK RabMAb 100µl, IHC, ICC Human $250 New Peroxiredoxin RabMAb 100µl, IHC, ICC, FC Human $250 PKC Phospho (Alpha, pt638) RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $285 PKC Phospho (Delta, pt507) RabMAb 100µl Human $285 PKC Phospho (Delta, py311) RabMAb 100µl, IHC IP Human, Mouse $285 PKC Phospho (Gamma, pt514) RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $285 PKC Phospho (Mu, ps744/748) RabMAb 100µl, IP Human $285 PKC Phospho (Mu, ps916) RabMAb 100µl, IHC, IP Human $285 PKC Phospho (Zeta, pt560) RabMAb 100µl, IHC, ICC Human, Mouse, Rat $285 PKC Phospho (Zeta, Lambda, pt410/403) RabMAb 100µl, IHC, ICC Human $285 New Peroxiredoxin RabMAb 100µl, IHC, ICC, IP Human $250 PKN RabMAb 100µl, FC Human $250 New PHD RabMAb 100µl, ICC, FC Human $250 PKN RabMAb 100µl, IHC, ICC, IP Human $250 New PHD RabMAb 100µl, IHC, ICC, FC Human, Mouse, Rat $250 PKR (C-term) RabMAb 100µl, IHC, ICC, IP Human $250 Phox - See p40 PKR (N-term) RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 New Phospholamban Phospho (ps16) RabMAb 100µl, IP Human Mouse $285 PKR Phospho (pt446) RabMAb 100µl, IHC, ICC, IP Human, Mouse $285 PI3-kinase p110 subunit (Alpha) RabMAb 100µl, ICC, IP Human $250 PKR Phospho (pt451) RabMAb 100µl Human $285 PI3-kinase p110 subunit (Beta, N-term) RabMAb 100µl, FC, IP Human $250 PI3-kinase p110 subunit (Delta) RabMAb 100µl, ICC, IP Human $250 PI3-kinase p110 subunit (Gamma, N-term) RabMAb 100µl, FC, IP Human $250 PLAP RabMAb 100µl, IHC, ICC Human $250 PLAP RabMAb 100µl IHC Human $205 PLC β III Phospho (ps1105) RabMAb 100µl Human $285 PLC γ I RabMAb 100µl, ICC, IP Human, Mouse, Rat $250 PI3-kinase p85 subunit (Alpha, C-term) RabMAb 100µl, IHC, ICC, FC, IP Human, Rat $250 PLC γ I (C-term) RabMAb 100µl Human $210 PIAS1 (C-term) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 PLC γ I Phospho (py771) RabMAb 100µl Human $285 Pim RabMAb 100µl, IHC, ICC Human $250 PLC γ I Phospho (py783) RabMAb 100µl, ICC Human $285 Pin RabMAb 100µl, FC, IP Human, Mouse, Rat $250 PLC γ I Phospho (py783) RabMAb 100µl, ICC Human $285 Pin1 Phospho (ps16) RabMAb 100µl, ICC Human $285 PLC γ I Phospho (py1245) RabMAb 100µl, ICC Human $285 PKA C (Alpha) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 PLC γ II RabMAb 100µl Human $210 PKA C Phospho (Gamma, pt197) RabMAb 100µl, IHC ICC, IP Human, Mouse, Rat $285 PLC γ II Phospho (py1197) RabMAb 100µl, ICC, IP Human $285 PKA RII (C-term) RabMAb 100µl, IHC, ICC, IP Human, Mouse $250 PLC γ II Phospho (py1217) RabMAb 100µl, IHC, IP Human $285 PKA RII Phospho (ps96) RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $285 PLC γ II Phospho (py759) RabMAb 100µl, ICC, IP Human $

25 PLD1 (N-term) RabMAb 100µl, ICC, FC Human, Mouse $250 Plectin RabMAb 100µl, IHC, IP Human, Mouse, Rat $250 Pleiotrophin RabMAb 100µl, IP Human, Mouse, Rat $250 Plexin-A RabMAb 100µl, ICC, FC Human, Mouse, Rat $250 Plexins are large transmembrane receptors for semaphorins. It contains a sema domain and a highly conserved cytoplasmic domain. Plexins are classified into four groups: A, B, C, D. Plexin-A1 is a co-receptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. It is necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plexin-A1 plays a role in axon guidance, invasive growth and cell migration. Plexin-A1 modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Plexin-A1 is specific in fetal brain, lung, liver and kidney. Specificity: A synthetic peptide corresponding to residues in human Plexin-A1 was used as an immunogen. on (A) K562 (B) 293T (C) HUVEC (D) HepG2 cell lysates and (E) Fetal Brain tissue lysates Pol II RabMAb 100µl, ICC, FC Human $250 Pol II Phospho (ps1801) RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $285 Polyethylene Glycol (PEG) RabMAb 100ug, ELISA, IHC $225 Polyethylene Glycol (PEG)-Biotin RabMAb 100ug, ELISA, IHC $305 New PON RabMAb 100µl, IHC, IP Human $250 IHC on breast adenocarcinoma Paraoxonase 1 (PON 1) is an esterase and lactonase that is synthesized in the liver and secreted into blood, associated exclusively with high density lipoproteins (HDL). It hydrolyzes the toxic oxon metabolites of several organophosphorous insecticides and nerve agents. This protein has been implicated in protection from atherosclerosis. Specificity: A synthetic peptide corresponding to residues near the N-terminus in human PON 1 was used as an immunogen. Pou Domain Protein 3A RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 PP1 (Alpha) RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 PP1 (Beta) RabMAb 100µl, IHC, FC, IP Human, Mouse, Rat $250 PP1 Phospho (Alpha, pt320) RabMAb 100µl, IHC, IP Human, Mouse, Rat $285 PP2A RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 PP2A (N-term) RabMAb 100µl, IHC Human, Mouse, Rat $250 PP2A Phospho (py307) RabMAb 100µl, IHC, ICC, IP Human, Rat $285 PP2B (N-term) RabMAb 100µl, FC, IP Human, Mouse, Rat $250 PP2C (Alpha) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 PR RabMAb 100µl, IHC, ICC, IP Human, Rat $250 PR Phospho (ps190) RabMAb 100µl, IHC, ICC, IP Human $285 PRA1 (C-term) RabMAb 100µl, FC, IP Human, Mouse, Rat $250 PRK RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 PRKDC RabMAb 100µl, IHC, ICC Human $250 PRMT RabMAb 100µl, IHC Human, Mouse $250 Prohibitin (C-term) RabMAb 100µl, IHC, FC, IP Human, Mouse, Rat $250 Prohibitin (N-term) RabMAb 100µl, IHC, FC, IP Human, Mouse, Rat $250 New Prolactin RabMAb 100µl Human $210 New Prostaglandin E Synthase RabMAb 100µl, ICC, IP Human, Mouse, Rat $250 Prostate-Specific Antigen (PSA) RabMAb 100µl, IHC Human $250 IHC on prostate carcinoma Prostate-specific antigen (PSA, Kallikrein-3, KLK3) is a serine protease that is usually secreted from the prostate gland and presented in seminal plasma. PSA function in the liquefaction of seminal coagulum, through hydrolysis of the high molecular mass seminal vesicle protein. Its substrates includes semenogelin I & II, fibronectin, insulin-like growth factor binding protein 3 (IGBP3), and laminin. Highly expressed by normal and malignant prostate cancer cells, PSA has been implicated in the growth, invasion, and metastasis of prostate cancer cells. Therefore, PSA is widely used as a diagnostic marker for prostate cancer. Recently, PSA has been suggested as an endothelial cell-specific inhibitor of angiogenesis. Specificity: A synthetic peptide corresponding to residues near the C-terminal of human PSA. Protein Kinase D RabMAb 100µl, IHC, ICC, FC Human, Mouse $250 Protein Kinase D2 Phospho (ps876) RabMAb 100µl, IP Human $285 PSD RabMAb 100µl, ICC, FC, IP Human, Mouse, Rat $250 PSD95 Phospho (ps295) RabMAb 100µl, ICC, IP Human, Mouse, Rat $285 PSD95 Phospho (ps418) RabMAb 100µl Human, Mouse, Rat $285 P-Selectin Glycoprotein Ligand RabMAb 100µl, ICC, IP Human $250 PSMA RabMAb 100µl, FC, IP Human $250 PSMA RabMAb 100µl, ICC Human $250 PTEN (C-term) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 PTEN Phospho (ps380) RabMAb 100µl, IHC, ICC Human, Mouse, Rat $285 PTEN Phospho (pt366/ps370) RabMAb 100µl, IHC, ICC, IP Human $285 PTP1B RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 PTP1B RabMAb 100µl, IHC, ICC, FC Human $250 PTP1B Phospho (ps352) RabMAb 100µl, ICC, IP Human $285 PTP1B Phospho (ps378) RabMAb 100µl, IHC, ICC Human $285 PTP1B Phospho (ps50) RabMAb 100µl Human $285 PUMA (C-term) RabMAb 100µl, IHC, ICC, FC, IP Human $250 New Pumilio RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse $250 New Pumilio RabMAb 100µl, ICC, IP Human, Mouse, Rat $250 Pyk2 - See FAK2 PRC RabMAb 100µl, IHC, ICC, FC, IP Human, Moues, Rat $250 PRC1 Phospho (pt481) RabMAb 100µl, IHC, ICC Human $285 Prealbumin RabMAb 100µl, IHC, FC Human $250 Presenilin RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 Presenilin RabMAb 100µl, FC Human, Mouse, Rat $250 Presenilin 1 Phospho (ps310) RabMAb 100µl, ICC Human $285 Presenilin RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 Presenilin 2 Phospho (ps327) RabMAb 100µl, IP Human, Mouse, Rat $285 Presenilin 2 Phospho (ps330) RabMAb 100µl Human, Mouse, Rat $285 Q Quinone Reductase 1 / NQO RabMAb 100µl, IP Human $250 Q NQO1(Quinone reductase 1) is a flavoenzyme that catalyzes two-electron reductive metabolism and detoxification of quinones and their derivatives leading to protection of cells against redox cycling and oxidative stress. NQO1/Quinoni 1 is mainly cytosolic, but its nuclear presence suggests its involvement in both chemoprevention and bioactivation of DNA-damaging antitumor agents. NQ01/Quinoni 1 may also play a role in the bioactivation of antitumor quinones such as mitomycin C (MMC), and has been proposed to have a protective effect against cancer caused by quinones and their metabolic precursors. Specificity: A synthetic peptide corresponding to the C-terminus of human NQO1 (Quinone reductase 1) was used as an immunogen. on (A) MCF-7, (B) HeLa, (C) A549 and (D) HepG2 cell lysates Prion Protein (PrP) RabMAb 100µl, IHC, ICC, FC Human, Mouse, Rat $250 R New RAB27A RabMAb 100µl, IHC, ICC, FC, IP Human, Rat $250 R Rab RabMAb 100µl, ICC, FC Human $250 Rac 1 - See Cdc

26 Rad17 Phospho (ps645) RabMAb 100µl Human $285 Rad17 Phospho (ps656) RabMAb 100µl, IHC, ICC Human $285 RIAM RabMAb 100µl, IHC, ICC Human, Mouse, Rat $250 RIAM RabMAb 100µl, IHC, icc, IP Human, Mouse $250 Radixin RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 Raf RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 RAIDD RabMAb 100µl, FC, IP Human, Rat $250 RAIDD (C-term) RabMAb 100µl, IHC, ICC, FC, IP Human $250 RanBP9 (C-term) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse $250 New RanGAP RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 Rap RabMAb 100µl, ICC, IP Human, Mouse, Rat $250 Rap RabPAb 100µl, IHC, FC Human, Mouse, Rat $250 Ribosomal Protein S6 Phospho (ps235/236) IHC on breast adenocarcinoma RabMAb 100µl, IHC, ICC, IP Human $285 Ribosomal protein S6 (RPS6) belongs to S6E family of ribosomal proteins and it is involved in the control of cell growth and proliferation via selective translation. It is a major substrate of Ribosomal Protein S6 Kinase (RSK) in the eukaryote ribosomes. The phospholyation of RPS6 has been linked to increase in selective 5 TOP translation. Specificity: A synthetic peptide corresponding to residues surrounding serine 235/236 of human Ribosomal Protein S6 was used as an immunogen. on HeLa cells lysate. Cells were either (A) untreated (B) treated with Calyculin A Rap1GAP (C-term) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 Rap1GAP (N-term) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 Raptor RabMAb 100µl, IHC, ICC, FC, IP Human $250 RAR (Alpha) RabMAb 100µl, FC Human, Mouse $250 Ras - See p21 RasGap RabMAb 100µl, IHC, ICC Human, Rat $250 RasGAP (C-term) RabPAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 RAX / PRKRA RabMAb 100µl, IHC Human, Mouse, Rat $250 Rb RabMAb 100µl Human $210 Retinoblastoma tumor suppressor protein (Rb) is associated with DNA binding activity and is thought to play a significant role in controlling cell cycle progression during tumor growth. Cell cycle-dependent phosphorylation by cdk s inhibits Rb binding, thus allowing cell cycle progression. Rb inactivation and cell cycle progression likely requires first phosphorylation by cyclin D-cdk4/6 followed by cyclin E-cdk2 phosphorylation Specificity: A synthetic peptide corresponding to residues in human Rb was used as an immunogen. on (A) Jurkat and (B) K562 Rb Phospho (ps780) RabMAb 100µl, ICC, IP Human $285 Rb Phospho (pt356) RabMAb 100µl, IHC, ICC, IP Human $285 Rb Phospho (pt373) RabMAb 100µl, IHC, ICC, IP Human $285 Rb Phospho (pt821) RabMAb 100µl, ICC, IP Human $285 Rb RabMAb 100µl, IHC, FC Human $250 RKIP RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 RKIP Phospho (ps153) RabMAb 100µl, IHC, ICC Human, Rat $285 ROCK RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 ROCK RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 Ron RabMAb 100µl, IHC, ICC, FC, IP Human $250 New ROR RabMAb 100µl, ICC, FC Human $250 RPA RabMAb 100µl, IHC, IP Human, Mouse, Rat $250 RPA RabMAb 100µl, IHC, ICC, FC, IP Human $250 RPA RabMAb 100µl, FC, IP Human $250 RSK1 (C-term) RabMAb 100µl, IP Human, Mouse, Rat $250 RSK1 (N-term) RabMAb 100µl, IHC, ICC, IP, FC Human, Mouse, Rat $250 RSK1 Phospho (ps380) RabMAb 100µl, ICC, IP Human, Mouse, Rat $285 RSK1 Phospho (pt359/ps363) RabMAb 100µl, IHC, ICC, IP Human, Mouse $285 RSK1 Phospho (pt573) RabMAb 100µl Human $285 RSK2 (C-term) RabMAb 100µl, IHC, FC, IP Human, Rat $250 RSK2 (N-term) RabMAb 100µl, IHC, FC, IP Human, Mouse, Rat $250 RSK2 Phospho (ps227) RabMAb 100µl, IP Human, Mouse, Rat $285 RSK3 Phospho (pt353/356) RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $285 RSK4 (N-term) RabMAb 100µl, IHC, ICC, FC Human $250 RSK4 Phospho (ps235) RabMAb 100µl, IHC, ICC, FC Human, Mouse $285 New RUNX RabMAb 100µl, IHC Human, Mouse $250 Rb2 Phospho (ps672) RabMAb 100µl, IP Human $285 Rb2 Phospho (ps952) RabMAb 100µl, IHC, ICC Human, Mouse $285 RelB RabMAb 100µl, IHC, ICC, IP Human $250 RBBP RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 RBBP RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse $250 RelB (C-term) RabMAb 100µl, FC, IP Human $250 Rest RabMAb 100µl, FC Human $250 IHC on breast adenocarcinoma RUNX1 (PEBP2-alpha B, Runt-related transcription factor 1, AML1) is a pivotal transcription factor essential for haematopoietic stem cell generation in the vascular regions of the aorta, vitelline and umbilical arteries, yolk sac and placenta. So far, 11 isoforms of RUNX1 has been reported. It binds DNA in cooperation with CBFbeta to activate or repress transcription, dependent upon cellular context and interaction with a variety of co-activators and co-repressors. Specificity: A synthetic peptide corresponding to residues in human RUNX1 was used as an immunogen. IHC on human tonsil (Left) on (A) Molt-4, (B) fetal thymus and (C) mouse thymus (Right) RGS RabMAb 100µl, ICC, FC, IP Human $250 Rheb RabMAb 100µl, IHC, ICC, FC Human $250 Rho RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 Rho (N-term) RabMAb 100µl, IHC, ICC Human, Mouse, Rat $250 New Rho GDI RabMAb 100µl, ICC Human $250 RUNX RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse $250 New RUVBL RabMAb 100µl Human, Mouse $210 S S100 (Beta, C-term) RabMAb 100µl, IHC, IP Human, Mouse, Rat $250 S New S100A RabMAb 100µl, ICC, FC, IP Human, Mouse $250 S100A RabMAb 100µl, IHC, ICC, IP Human $250 SAM RabMAb 100µl, IHC, ICC Human, Mouse, Rat $250 New SATB RabMAb 100µl, IHC, ICC, IP Human, Mouse $250 New SATB RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 New SCARF RabMAb 100µl, IHC, ICC, IP Human $

27 SCF RabMAb 100µl, IHC, ICC, FC Human $250 Securin RabMAb 100µl, IHC, ICC, FC, IP Human $250 SEK - See MEKK4 New SENP RabMAb 100µl, IHC, ICC Human $250 New Serum amyloid A4 (SAA4) RabMAb 100µl, IHC, ICC, FC Human $250 IHC on normal human kidney Serum amyloid A (SAA) proteins are family of apolipoproteins of high density lipoprotein (HDL). SAA4 and SAA5 exist as the minor apolipoproteins on HDL, but this group of SAA constitutes more than 90% of all the SAA during homeostasis, and it is thought to play a role in the normal functioning of the HDL particle (1, 2). The distribution of SAA4 is restricted to two lipoprotein subclasses; therefore, SAA4 has been suggested be a factor in lipid transfer between lipoprotein classes. Specificity: A synthetic peptide corresponding to residues near the C-terminal of human SAA4 was used as an immunogen. New Serum amyloid A4 (SAA4) RabMAb 100µl, IHC, ICC, FC Human $250 Serum amyloid P-component RabPAb 100µl, IHC Human, Mouse, Rat $250 Serum amyloid P-component (N-term) RabMAb 100µl, IHC Human $250 SGK RabMAb 100µl, IHC, FC, IP Human, Mouse, Rat $250 SHC RabMAb 100µl, FC, IP Human, Mouse, Rat $250 SHC1 Phospho (py239/40) RabMAb 100µl Human $285 SHC1 Phospho (py427) RabMAb 100µl Human, Mouse, Rat $285 SHIP RabMAb 100µl, IHC, FC, IP Human $250 SHIP RabPAb 100µl, IHC, IP Human $250 SHIP Phospho (py1020) RabMAb 100µl, IHC, IP Human $285 SHP-1 (C-term) RabMAb 100µl, IHC, FC, IP Human, Mouse, Rat $250 SHP RabMAb 100µl, IHC, IP Human $250 SHP RabMAb 100µl, IP Human, Mouse, Rat $250 SHP-2 Phospho (py542) RabMAb 100µl, ICC, IP Human, Mouse $285 SHP-2 Phospho (py582) RabMAb 100µl Human $285 SIRT RabMAb 100µl, IHC, ICC, IP Human $250 SIRT1 (N-term) RabMAb 100µl, IHC, ICC, IP, FC Human $250 SIRT1 Phospho (ps27) RabMAb 100µl, IP Human $285 SIRT1 Phospho (ps47) RabMAb 100µl, IHC, ICC Human $285 SIRT RabMAb 100µl Human $210 SIRT2 (C-term) RabMAb 100µl, ICC, FC, IP Human $250 SKP RabMAb 100µl, FC Human, Mouse, Rat $250 SKP RabMAb 100µl, IHC, FC Human, Mouse, Rat $250 IHC on human brain SKP1 (S-phase kinase-associated protein 1) is a core component of the Skp1-Cullin-F-box (SCF) ubiquitin ligase protein complex. It mediates the ubiquitination of proteins involved in cell cycle progression, transcriptional regulation, and signal transduction. Independent of its function as a part of the SCF complex, SKP1 also functions in mitotic exit and cytokinesis. A possible contribution to the function of SKP1 in the mitotic exit is its physical interaction with Bfa1, a key negative regulator of the mitotic exit network. Specificity: A synthetic peptide corresponding to residues in human SKP1 were used as an immunogen. SLP-76 Phospho (py113) RabMAb 100µl, FC Human $285 SLP-76 Phospho (py145) RabMAb 100µl, ICC, FC Human $285 Smac/Diablo RabMAb 100µl, IHC, ICC, IP, FC Human, Rat $250 Smad RabMAb 100µl, ICC Human, Mouse $250 Smad RabMAb 100µl, IHC, ICC, FC Human $250 Smad RabMAb 100µl, IHC, ICC, FC, IP Human, Rat $250 Smad RabMAb 100µl, IHC, ICC, IP Human, Rat $250 Smad3 Phospho (ps423/425) RabMAb 100µl, IHC, ICC Human, Rat $285 Smad4 (C-term) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 Smad RabMAb 100µl, ICC, FC Human, Mouse, Rat $250 Smad5 Phospho (ps463/465) RabMAb 100µl, ICC Human $285 ICC on HeLa Smad5 is a member of the Mothers Against Dpp (MAD)-related family of proteins. Smad 1, 5 and 8 serve as pathway-restricted Smads for the bone morphogenetic proteins (BMPs) signaling pathway. Smad5 is directly activated by BMP type Ia or Ib receptors upon BMP-2 stimulation and transduced BMP-2 signals to the nucleus by forming a complex with Smad 4, activating the transcription of the target gene in the nucleus. BMP activates Smad5 by phosphorylation at Ser463 and Ser465, which are the equivalent phosphorylation sites for Smad 1 and Smad 8. Specificity: A phospho specific peptide corresponding to residues surrounding Serine 463 and 465 of human Smad5. on HeLa cell lysate. Cells were either (A) untreated (B) treated with BMP-4 Smad5 Phospho (ps463/465) RabMAb 100µl, IHC, ICC Human, Mouse, Rat $285 SMC1 Phospho (ps957) RabMAb 100µl, IHC, ICC Human $285 SMC1 Phospho (ps957) RabMAb 100µl, IHC, IP Human $285 SMC1 Phospho (ps966)) RabMAb 100µl, ICC Human $285 Smurf RabMAb 100µl Human, Mouse, Rat $210 Smurf2 (IHC/ICC Specific) RabMAb 100µl IHC, ICC Human $250 SOD RabPAb 100µl, IHC, ICC, IP Human $250 SOD RabMAb 100µl, IHC, ICC, FC Human, Rat $250 SOD RabMAb 100µl, IHC, ICC, IP Human $250 SOD RabMAb 100µl, IHC Human, Mouse, Rat $250 Somatostatin Receptor 2 / STT RabMAb 100µl, IHC, ICC, IP, FC Human, Mouse, Rat $250 Sonic Hedgehog Protein / SHH (C-Product) RabMAb 100µl, IHC, FC, IP Human $250 SOX RabMAb 100µl, IHC, ICC Human $250 SOX RabMAb 100µl, IHC, IP Human $250 IHC on breast adenocarcinoma SOX2 is a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. It is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. SOX2 is necessary for regulating multiple transcription factors that affect Oct3/4 expression. An essential function of SOX2 is to stabilize embryonic stem cells in a pluripotent state by maintaining the requisite level of Oct3/4 expression. Specificity: A synthetic peptide corresponding to residues in human SOX2 was used as an immunogen. on NCCIT cell lysate SPP RabMAb 100µl, IHC, ICC, FC Human $250 SR-B1 Scavenge Receptor RabMAb 100µl, IHC, ICC Human, Mouse, Rat $250 Src RabMAb 100µl, IHC, ICC Human, Rat $250 Src RabMAb 100µl, IHC Human $250 Src Phospho (py529) RabMAb 100µl, ICC, IP Human, Mouse, Rat $285 ST RabMAb 100µl, IHC, ICC, FC Human, Mouse $250 ST RabMAb 100µl, IHC, FC Human, Mouse $250 Stat RabMAb 100µl, FC, IP Human, Mouse $

28 Stat RabMAb 100µl, IHC, ICC Human, Rat $250 Stat RabMAb 100µl, IHC, FC, IP Mouse $250 Stat RabMAb 100µl, IHC, ICC, IP Human $250 Stat RabMAb 100µl, ICC, IP Human, Mouse, Rat $250 Stat-3 Phospho (ps727) RabMAb 100µl, IHC, ICC, IP Human, Rat $285 Stat-3 Phospho (py705) RabMAb 100µl, IHC, ICC, IP Human, Mouse $285 Stat-5 (Alpha, C-term) RabMAb 100µl, IHC, ICC, FC, IP Human, Rat $250 Stat-5 Phospho (py694) RabMAb 100µl, IHC, ICC, IP Human, Mouse $285 Stat RabMAb 100µl, ICC, FC, IP Human $250 Stat RabMAb 100µl, IHC, ICC, IP Human, Mouse $250 Stathmin RabPAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 Stathmin RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 Stathmin RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 Stathmin Phospho (ps62) RabMAb 100µl, IHC, IP Human $285 Sulfotransferase 1A3 / 1A RabMAb 100µl. ICC, FC Human $250 SUMO RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 Left: ICC on HeLa Middle: IHC on human lung carcinoma Right: on (A) HeLa and (B) NIH3T3 Small ubiquitin-related modifier-1 (SUMO-1), also known as SMT3, Sentrin, GMP1 UBL1 and PIC1, is a member of the ubiquitin like family (1-2). Structurally similar to ubuquitin, SUMO-1 does not mark protein for degradation (SU- MOlation) but instead seems to be involved in the modulation of proteinprotein interaction. It also participates in a number of cellular processes such as nuclear transport, transcriptional regulation, apoptosis and protein stability. SUMO-1 is also known to form a complex with RanGAP1. Specificity: A synthetic peptide corresponding to residues near the C-term of human SUMO-1 was used as immunogen. New SUMO RabMAb 100µl, IHC Human, Mouse, Rat $250 Suppressor of Fused (SUFU) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 Suppressor of Fused (SUFU) RabMAb 100µl, IHC, FC, IP Human $250 Survivin RabMAb 100µl, IHC, ICC, FC, IP Human $250 Survivin RabMAb 100µl, IHC, ICC, FC Human $250 Syk RabMAb 100µl, IHC, ICC Human $250 Syk Phospho (py323) RabMAb 100µl, IHC, ICC Human $285 Syk Phospho (py525/526) RabMAb 100µl, IHC Human $285 Synapsin I Phospho (ps553) RabMAb 100µl, ICC Human, Mouse, Rat $285 Synapsin I Phospho (ps9) RabMAb 100µl, IHC, ICC Human, Mouse, Rat $285 Synapstin II RabMAb 100µl, IHC, ICC, FC Human, Mouse, Rat $250 Synaptojanin RabMAb 100µl, ICC, IP Human $250 Synaptophysin RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 Synaptophysin (C-term) RabMAb 100µl, IHC, ICC Human, Mouse, Rat $250 SynGAP RabMAb 100µl, FC Human, Mouse, Rat $250 Synip RabMAb 100µl, IHC, FC Human, Mouse, Rat $250 Synuclein (Alpha) RabMAb 100µl, ICC Human, Mouse, Rat $250 Synuclein Phospho (Alpha, ps129) RabMAb 100µl Human $285 T TAB RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 T Tau RabMAb 100µl, ICC, FC Human, Mouse, Rat $250 ICC on SH-SY5Y Tau is a microtubule binding protein that promotes microtubule assembly and stability. Tau is found to be the major component of the paired helical filaments (PHFs) found in the brains of patients with Alzheimer disease (AD). Tau is hyperphosphorylated in PHFs, and specific phosphorylation sites have been implicated in the loss of Taus association with the membrane cortex during AD disease state, including Ser 199/202, Thr 231, and Ser 393/404. Glycogen synthase kinase-3, or GSK-3, phosphorylates Tau on Ser 396. Specificity: A synthetic phospho-peptide corresponding to residues surrounding serine 622 of human Tau was used as an immunogen. Tau Phospho (ps396) RabMAb 100µl, IHC, ICC, IP Human, Rat $285 Tau Phospho (ps515) RabMAb 100µl, IHC, ICC, IP Human $285 Tau Phospho (ps516) RabMAb 100µl Human, Mouse, Rat $285 Tau Phospho (ps519) RabMAb 100µl, IP Human, Mouse, Rat $285 Tau Phospho (pt548) RabMAb 100µl, IP Human, Mouse, Rat $285 Tau Phospho (ps579) RabMAb 100µl Human $285 Tau Phospho (ps673) RabMAb 100µl, ICC Human $285 Tau Phospho (ps721) RabMAb 100µl, IHC Human, Mouse, Rat $285 Tau Phospho (ps739) RabMAb 100µl Human $285 TBK1 - See NAK TC RabMAb 100µl, ICC Human $250 TCF-1 (Alpha) RabMAb 100µl, IHC, ICC, FC Human $250 TCF RabMAb 100µl, FC Human $250 TCF RabMAb 100µl, IHC, ICC, FC, IP Human $250 New TCP1 Alpha RabMAb 100µl, IHC, ICC, IP Human $250 New TCP1 Beta RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 New TCP1 Beta RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 TdT RabMAb 100µl, ICC Human $250 TdT RabMAb 100µl, FC Human $250 TEC RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 TGIF (C-term) RabMAb 100µl, IP Human $250 Thiophosphate Ester RabMAb 50µl Human, Mouse, Rat $305 Thymidine Kinase RabMAb 100µl, IHC, ICC, FC, IP Human $250 Thymidine Kinase RabMAb 100µl, ICC, FC Human $250 Thyroglobulin RabMAb 100µl, IHC, IP Human $250 IHC on human papillary thyroid carcinoma Thyroglobulin (TG) is a dimeric glycoprotein specific to the thyroid gland which belongs to the type-b carboxylesterase/lipase family. It is the precursor of the iodinated thyroid hormones triiodothyronine (T3) and thyroxine (T4). Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3, and defective or impaired TG synthesis usually results in congenital goitrous hypothyroidism, virtual absence of TG in thyroid tissue, and the presence of an elevated concentration of iodoalbumin. The final result of these abnormalities is a decreased rate of T3 and T4 synthesis. Specificity: A synthetic peptide corresponding to residues in human Thyroglobulin was used as an immunogen. on human thyroid lysate Thyroglobulin RabMAb 100µl, IP Human $250 TIMP RabMAb 100µl Human $210 TIRAP RabMAb 100µl, IHC Human, Mouse, Rat $250 TLR-1 (Extracellular) RabMAb 100µl, IP Human $250 TLR-2 (Extracellular) RabMAb 100µl, ICC Human $250 New TMPRSS RabMAb 100µl, IHC, ICC, FC Human $

29 TNF (Alpha) RabPAb 100µl Human $210 TNF (Alpha) RabMAb 100µl Hu $210 TTF RabMAb 100µl, IHC, ICC, FC Human, Mouse, Rat $250 New TTF RabMAb 100µl, IHC, ICC, IP Human $250 TNF (Beta) RabMAb 100µl Human $210 TNFAIP RabMAb 100µl, IHC, ICC, FC Human $250 TNFR RabMAb 100µl, FC Human $250 New TNNT RabMAb 100µl Human, Mouse, Rat $210 TOPK - See PBK Topoisomerase II (Alpha) RabMAb 100µl, IHC, IP Human, Mouse $250 IHC on human breast carcinoma IHC on human stomach Trefoil factor 1 (TFF1), a member of the trefoil factor family, is a stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. It belongs to a family of abundant GI3 peptides with a distinct 3-loop structure formed by a highly conserved motif of cysteine disulfide bonds, which confer them with luminal stability. In breast cancer, its regulation by estrogen is an indicator of estrogen receptor (ER) functionality. Specificity: A synthetic peptide corresponding to residues in human TFF1 was used as an immunogen. Topoisomerase II Phospho (Alpha, ps1106) Topoisomerase II Phospho (Alpha, pt1343) RabMAb 100µl, IHC, ICC Human $ RabMAb 100µl, IHC, ICC Human $285 New TORC RabMAb 100µl, ICC, FC Human, Mouse, Rat $250 TORC RabMAb 100µl, IHC, IP Human $250 Torsin A RabMAb 100µl, IP Human, Mouse, Rat $250 Tpl RabMAb 100µl Human $210 TPPP RabMAb 100µl, IHC, ICC, FC Human, Mouse, Rat $250 New TPPP RabMAb 100µl, IHC, ICC, IP Human $250 TRADD RabMAb 100µl Human $250 TRAF RabMAb 100µl, IHC, ICC, FC Human $250 TRAF RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 TRAF6 (C-term) RabMAb 100µl, ICC Human, Mouse, Rat $250 New TRF RabMAb 100µl, FC, IP Human $250 Transcription factor PU RabMAb 100µl, IHC, ICC, IP Human $250 Transcription factor PU RabMAb 100µl, IHC Human $250 Transthyretin RabMAb 100µl, IHC, ICC, FC, IP Human $250 TRAP cleavage (CD40 Ligand) RabMAb 100µl, FC Human, Mouse, Rat $250 TRIB RabMAb 100µl, IP Human $250 TRIB RabMAb 100µl Human, Mouse, Rat $250 Trk RabMAb 100µl, FC, IP Human, Mouse, Rat $250 TrkA RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 Trk B Phospho (py817) RabMAb 100µl, ICC, IP Human, Rat $285 Troponin RabMAb 100µl, IHC, IP Human $250 Troponin T Type RabMAb 100µl, IHC, IP Human $250 Troponin T type 2 (TNNT2) is a cardiac troponin T isoform expressed in the human heart, that is essential for calcium-regulated myofibrillar ATPase activity. Troponin T (TnT) anchors the complex to the thin filaments in vertebrate striated muscle, and functions as a regulatory system for muscle contraction in response to changes to intracellular calcium ion concentration. All subunits of Tnnt2 have been associated with hypertrophic cardiomyopathy (HCM). New TTF RabMAb 100µl, IHC, ICC, IP Human $250 Tuberin RabMAb 100µl, IHC, FC, IP Human $250 Tuberin Phospho (ps939) RabMAb 100µl, ICC Human, Mouse, Rat $285 Tuberin - See TSC2 Tubulin (Alpha) RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 New Tubulin (Alpha) RabMAb 100µl, IHC, ICC, FC Human, Mouse, Rat $250 Tubulin (Beta) RabPAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 Tubulin (Beta) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 Tubulin (Beta, Class III, C-term) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 Tubulin (Beta, Class III, C-term) RabMAb 100µl, IHC, FC, IP Human, Mouse, Rat $250 Tubulin Phospho (Alpha, py272) RabMAb 100µl, ICC Human $285 Tyk RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 Tyrosinase (TYR) RabMAb 100µl, IHC, FC, IP Human, Mouse, Rat $250 Tyrosine 3-Hydroxylase RabMAb 100µl, ICC, FC Human, Mouse, Rat $250 Tyrosine 3-Hydroxylase RabMAb 100µl, ICC, FC Human, Mouse, Rat $250 U UBC RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 U UBC RabMAb 100µl, ICC, IP Human $250 UBC RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 UBF RabMAb 100µl, IHC, ICC, FC Human, Mouse $250 Ubiquitin (C-term) RabMAb 100µl, IHC Human, Mouse, Rat $250 V VAMP RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 V Vav RabMAb 100µl, ICC, IP Human, Rat $250 Vav Phospho (py174) RabMAb 100µl, ICC Human $285 Vav RabMAb 100µl, IHC, ICC, IP Human, Mouse, Rat $250 Vav RabPAb 100µl, IHC, ICC, FC, IP Human, Mouse $250 Vav3 (Pan) RabMAb 100µl, FC, IP Human, Mouse $250 VE-Cadherin RabMAb 100µl, FC, IP Human $250 VEGF (C-term) RabMAb 100µl, IHC, ICC, FC, IP Human $250 IHC on human cardiac muscle Specificity: A synthetic peptide corresponding to residues in human Troponin T type 2 was used as an immunogen. VEGFR1 (N-term) RabMAb 100µl, IHC, ICC, IP Human, Mouse $250 VEGFR RabMAb 100µl, IP Human $250 TRPC RabMAb 100µl, FC, IP Human, Rat $250 New Vimentin RabMAb 100µl, IHC, ICC Human $250 Tryptophan Hydroxylase 1 (TPH1) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 New Tryptophany-tRNA sythase RabMAb 100µl, IHC, ICC, FC, IP Human $250 TSC RabMAb 100µl, IHC Human $250 TSC2 (C-term) RabMAb 100µl, IHC, FC Human, Mouse, Rat $250 TSK - See EMTK 54 55

30 Vimentin RabMAb 100µl, IHC, IP Human, Mouse, Rat $205 New Vimentin RabMAb 100µl, IHC, ICC, FC Human, Mouse, Rat $250 ICC on HeLa IHC on gastric adenocarcinoma Vimentin is the most common member of intermediate filament (IF) family and one of the main components in cytoskeleton structure. It is expressed during cell development and differentiation in variety of mescencymal cells and cell types derived from mesoderm. Vimentin is essential in the role of cell integrity and cytoskeletal stability. PAK phosphorylates at Ser25, Ser38, Ser50, Ser65 and Ser72 which induces Vimentin specific reorganization. Specificity: A synthetic acetylated peptide corresponding to C-terminus of human Vimentin was used as an immunogen. Vimentin Phospho (ps38) RabMAb 100µl Human, Mouse, Rat $285 Vimentin Phospho (ps72) RabMAb 100µl, IP Human, Mouse, Rat $285 Vimentin Phospho (ps82) RabMAb 100µl Human, Mouse, Rat $285 Vitamin D-binding protein RabMAb 100µl, ICC, FC Human $250 Vitamin D-binding protein RabMAb 100µl, IHC, ICC, FC Human $250 Vitronectin RabMAb 100µl, IHC, IP Human $250 Vitronectin RabMAb 100µl, IHC, ICC Human, Mouse, Rat $250 VLA (Alpha 4) RabMAb 100µl, IHC, ICC, IP Human $250 W WASP RabMAb 100µl, ICC, FC, IP Human, Mouse, Rat $250 W WASP RabMAb 100µl, IHC, ICC Human $250 Support Products Secondary Antibodies, Controls, Cell Lysis Buffer Product Name Catalog # Quantity Applications Secondary Antibodies Species Reactivity Goat Anti-Rabbit IgG (H+L) - HRP ml, IP-Blot, ELISA Rabbit IgG $195 Goat Anti-Rabbit IgG Polymer HRP ml IHC Rabbit IgG Contact us for pricing Rabbit IgG Control ISO-XXXX 100µl FC, IHC - $89 Control Cell Lysates HeLa µg - - $105 Jurkat µg - - $105 Jurkat + Camptothecin µg - - $155 MCF µg - - $155 K µg - - $105 Daudi µg - - $105 A µg - - $105 A431 + EGF µg - - $155 Other Support Products Blocking Peptides Please Inquire 100µg - - $89 Cell Lysis Buffer (non-denaturing) ml - - $75 Price WASP RabMAb 100µl, IHC, ICC Human $250 New Wilm s Tumor RabMAb 100µl, IHC Human $250 IHC human fetal kidney IHC on Wilm s Tumor Wilm s Tumor (WT) is a 55 kda protein thought to play a major role in various cancers and developmental disorders, commonly kidney tumors and glomerular diseases. WT is a zinc finger transcription factor that is mutated in Wilm s tumors and highly expressed in a wide variety of other malignancies. WT1 consists of two major isoforms; WT1 (-KTS), a transcription factor, and WT1 (+KTS). Specificity: A recombinant protein corresponding to the N-terminus of human WT was used as an immunogen. WSTF RabMAb 100µl, IHC, ICC, FC Human, Mouse, Rat $250 Y YAP RabMAb 100µl, IHC, ICC, FC, IP Human $250 Y YAP65 Phospho (ps127) RabMAb 100µl, IHC Human $285 YBOX1 / YB RabMAb 100µl, IP, FC Human $250 YBOX1 / YB-1 (C-term) RabMAb 100µl, IHC, ICC, FC, IP Human, Mouse, Rat $250 Z ZAP RabMAb 100µl, FC, IP Human, Mouse, Rat $250 Z New ZAP RabMAb 100µl, IHC, ICC, IP Human $250 ZAP-70 (C-term) RabMAb 100µl, IHC, ICC, FC, IP Human $250 ZAP-70 Phospho (py292) RabMAb 100µl, IHC, ICC, FC, IP Human $285 ZAP-70 Phospho (py492) RabMAb 100µl, IP Human $285 Antibody Sampler Packs For recommended Protocols and FAQs - See Support We have specifically selected several of our more popular antibodies into sampler kits for customers to evaluate specific pathways. 40µl of each antibody are provided in each kit. Product Name Catalog # Quantity Applications Species Reactivity Apoptosis Sampler Kit µl per vial, IHC, ICC, IP, FC Human, Mouse, Rat $595 Bcl-2 Family Sampler Kit µl per vial, IHC, ICC, IP, FC Human, Mouse, Rat $595 Cytoskeletal Sampler Kit µl per vial, IHC, ICC, IP, FC Human, Mouse, Rat $595 Translation Control Sampler Kit µl per vial, IHC, ICC, IP, FC Human, Mouse, Rat $595 Cell Survival Sampler Kit µl per vial, IHC, ICC, IP, FC Human, Mouse, Rat $595 Akt Substrates Sampler Kit µl per vial, IHC, ICC, IP, FC Human, Mouse, Rat $595 MMP Family µl per vial, IHC, ICC, IP, FC Human, Mouse, Rat $595 PAK Family µl per vial, IHC, ICC, IP, FC Human, Mouse, Rat $295 Price 56 57

31 Support Products IgG Specific Rabbit Monoclonal Antibodies Monoclonal antibodies specific to various IgG. For use in immunoassays such as ELISA to detect IgG molecules. Anti-Human IgG Antibodies Product Name Cat # Amount Clone ID IgG 1κ IgG 1λ IgG 2k IgG 2λ IgG 3k IgG 3λ IgG 4k IgG 4λ IgA IgM Fc F(ab )2 Species Reactivity IgG Pan μg H NT Human $225 IgG 1 (H+L) μg H26-10 NT + NT NT NT Human $250 Price Kits - ELISA New EpiQ ELISA Kits Featuring RabMAb Technology Enjoy the benefits of High Affinity and Specificity of Rabbit Monoclonal Antibodies in all-inone ELISA kit Easy and consistent sandwich ELISA detection of Total and Phosholyated targets such as c-jun and ZAP-70 Kappa Light Chain Specific μg H Human $225 ELISA kits for high quality detection of other regulatory proteins - Histones, PBK Anti-Mouse IgG Antibodies New Epitomics EpiQ ELISA Kits offer high quality, accurate assays that detect important regulatory proteins and small molecules in one easy-to-use kit. Product Name Cat # Amount Clone ID IgG 1 IgG 2a IgG 2b IgG 3 IgA IgM Species Reactivity Price With the benefits of Epitomics patented Rabbit Monoclonal Technology to capture and detect, EpiQ ELISA kits offers higher specificity and sensitivity compared to traditional ELISA methods. IgG Pan μg M Mouse, Rat $250 IgG μg MIgG NT Mouse, $250 Fig 1. Detection of total and phosphorylated c-jun from Anisomycin treated 3T3 cell lysates via c-jun Dual Detection Kit (6116-1) and Western Blot. IgG μg M Mouse $250 IgG 2b μg M Mouse, Human $250 IgG 1 IgG 2a μg M Mouse, Rat $250 IgG 3 IgG μg M Mouse, Rat $250 IgG 2 Target Protein Detection Ab Streptavidin Biotin HRP TMB Substrate Fig 2. This assay employs the sandwich enzyme immunoassay technique that detects endogenous and/or phosphorylated levels of protein. IgG 2a μg M Mouse $250 Capture Ab Anti-Rat, Anti-Chicken, Anti-Sheep Antibodies Coated Microwells Product Name Rat IgG Rat IgG Cat # Amount Clone ID Rat IgG Mouse IgG Chicken IgY Sheep IgG Species Reactivity μg R NT NT Rat $ μg R NT NT Rat, Mouse $250 Chicken IgG (IgY) μg Ch.44-2 NT NT + NT Chicken $250 Sheep IgG μg Sh NT NT NT + Sheep $250 LEGEND : + (Positive), - (Negative), NT (Not Tested) All tests were based on ELISA testings Price ELISA Kit Catalog # Type Species Reactivity Price EpiQ ELISA Kits New Akt (Human Specific) Sandwich ELISA (96 Reactions) Human $450 c-jun Sandwich ELISA (96 Reactions) Human, Mouse, Rat $450 c-jun Phospho (pt91/93) Sandwich ELISA (96 Reactions) Human, Mouse, Rat $450 Histone H2B Acetyl (K5) Sandwich ELISA (96 Reactions) Human, Mouse, Rat $450 MIP-1 beta Sandwich ELISA (96 Reactions) Human, Mouse, Rat $450 PBK Sandwich ELISA (96 Reactions) Human, Mouse, Rat $450 ZAP-70 Total Sandwich ELISA (96 Reactions) Human, Mouse, Rat $450 ZAP-70 Phospho (py492) Sandwich ELISA (96 Reactions) Human, Mouse, Rat $450 Dual EpiQ ELISA Kits c-jun Dual Detection Total & Phospho (pt91/93) Zap-70 Dual Detection Total & Phospho (py492) Dual Sandwich ELISA (96 Reactions) Human, Mouse, Rat $ Dual Sandwich ELISA (96 Reactions) Human, Mouse, Rat $

32 Kits - ELISA (PEG) EpiQ PEG ELISA Kit Convenient Detection of PEGylated Molecules Kits - IHC Single & Dual IHC Kits Quantitate PEGylated molecules in plasma, serum or cell culture medium Highly sensitive assay accurately determines concentration of PEGylated molecules (ng/ml) Carry out Pharmacokinetic studies OD BSA-PEG ADI-PEG Mouse IgG-PEG Enjoy the benefits of High Affinity and Specificity of Rabbit Monoclonal Antibodies in all-in-one IHC kit All kits utilizes Polymer based secondary detection system for strong IHC staining Perform High Quality double staining with monoclonal antibodies on same tissue section EpiQ ELISA Kits helps you to achieve more consistent and accurate results in less time -- allowing you to focus on your result. Epitomics EpiQ PEG ELISA Kit offers a high quality, accurate assay that quantifies PEGylated molecules (ng/ml) in one easy-to-use kit. Polyethylene glycol (PEG) is an O-CH2-CH2 polymer, which is water-soluble, nontoxic, nonantigenic, and biocompatible. Covalent conjugation of PEG to therapeutic proteins increases their in vivo stability by protecting the protein from degradation, masking its immunogenic sites and reducing clearance. Qualitative and quantitative analysis of PEGylated molecules is important for both drug development and clinical applications. Therefore, this kit is developed to determine levels of PEGylated molecules in samples such as serum via ELISA. Anti-PEG RabMAb + H S PEG labeled HRP (H) PEG labeled Sample (S) S H S Competition TMB Fig 1. Competition between PEG labeled HRP (H) and PEG labeled sample (S) in PEG ELISA assay S H HRP (H) Activation S OD ng/ml Fig 2a Competition between PEGylated molecules and HRP-mPEG IgG-PEG (ng/ml) Mouse IgG-PEG y = 1.11x R = ng/ml Fig 2b Pharmacokinetics Experiment using the fitted curve y=1.11x Control Rat time (hours) Fig 2c Pharmacokinetics Experiment: Plot of PEGylated IgG concentration over time (hours) For more info - visit IHC Portal Epitomics IHC kits are a complete ready-to-use IHC staining system, designed to be utilized with Epitomics primary Rabbit Monoclonal antibodies (RabMAb ) for detection of specific target antigens in tissue samples. When combined with an appropriate RabMAb the IHC Staining Kit combines the superior antigen recognition of rabbit monoclonals antibodies with novel polymer based enzyme labeled secondary antibody which provides a stronger and cleaner signal than comparable non-polymer based secondary antibodies. For double IHC staining, pair any suitable RabMAb with a Mouse MAb for a high quality double staining using Epitomics Dual Staining IHC Kit. IHC Kit Catalog # Kit Type Species Reactivity Price Single Staining Kit Ace IHC Detection Kit Single Polymer Detection (DAB, 50 slides) Human, Mouse, Rat Contact us for pricing Dual Staining Kit Tandem IHC Staining Kit Double Polymer Detection (FastRed, DAB, 50 slides) Human, Mouse, Rat Contact us for pricing Kit Contents: 1. Antigen Retrieval solution (1X) 2. Peroxidase Block solution 3. Blocking solution 4. Primary antibody diluent 5. Negative control rabbit IgG (1X) 6. *Secondary anti-rabbit (HRP) and/or anti-mouse (AP) 7. *DAB or Fast Red tablets *Depending on the kit ELISA Kit Catalog # Type Species Reactivity Price PEG ELISA Kit Competitive ELISA (96 Reactions) Human, Mouse, Rat $525 Learn more about Epitomics ELISA Fig 1. HSP73 staining on human breast carcinoma using Ace IHC detection kit. Fig 2. Cytokeratin 8 (FastRed) and Ki-67 (DAB) on urinary bladder cancer tissue using Tandem IHC staining kit

33 Kits - Purification EpiMAX Purification Kits One Stop Antibody Purification System All-In-One Antibody Purification Kit Quick and Simple Peptide/Protein Immobilization Maximum Antibody Yield in Less Time Versatile Gel Matrix with High Binding Capacity and Stability EpiMAX Affinity Purification kit is a complete antibody purification solution for quick and easy purification of ultra pure antibodies. EpiMAX Affinity Purification kit utilizes Epitomics ASA (Activated Serial-A) Matrix Gel Technology in which the activated gel matrix in the kit can form highly stable covalent immobilization with any SH- or NH3- containing peptide/protein in a few simple steps (Figure 1). Highly verstile and stable, ASA Matrix Gel provides multiple benefits, from increased antibody binding capacity (Figure 2) to enhanced target antibody recovery (with the typical antibody purity being in the range of >95%) (Figure 3) compared to traditional peptide purification methods. Fig 1. Reaction scheme for coupling of peptde to ASA gel matrix mg/ml of gel EpiMAX Vendor A Binding Capacity Min Max % Recovery Antibody Recovery Efficiency 6.0% 1.0% Min EpiMAX 20% 18% Max Vendor A Fig 2. A comparison of min and max Antibody Binding Capacity (mg/ml of gel) between Epi- MAX TM and Vendor A s Purification Kit Fig 3. A comparison of minimum and maximum target antibody recovery (%) between EpiMAX and Vendor A. ELISA Kit Catalog # Type Price EpiMAX Purification Kit Antibody Purification (5 Antibodies) $395 For More EpiMAX Purification Kit Comparison Data and Benefits - Please visit 62

34 Custom Services Rabbit Monoclonal Antibody Development In the last six years, Epitomics has developed high quality custom Rabbit Monoclonal Antibodies using our patented rabbit fusion partner cell line. With several advantages over traditional monoclonal services (Table 1), we have provided services to customers in all the major pharmaceutical, biotech and academic institutions. The standard service as outlined at the bottom of the page is divided into three distinct phases (Table 2). Customers are involved in each phase to ensure the development of a high quality monoclonal antibody suited to their specifications. For More Info on Custom Service - Please Visit under Service Traditional Mouse Monoclonal Epitomics Rabbit Monoclonals (RabMAbs ) Antigen Recognition Limited Immune Response Small molecules peptides often non-immunogenic Usual recognition of 1-2 epitopes on a particular antigen Excellent response to broader range of antigens (small molecules, peptides, phospholaytion site) Possible to generate antibodies to rodent proteins Recognition of multiple epitopes (2+) on an antigen. Affinities Typical binding affinity at kda Rare to reaches maximum binding affinity at 10-9 kda Provides 1000 times higher binding affinity compared to Mouse Monoclonal. Minimum kda Maximum kda Specificity Medium to High High Applications, IHC, ICC, IP, FC, ELISA. Requires antigen retrieval pretreatment (Heat or Enzyme) on paraffin embedded tissues sections. Not suitable to use for staining rodents tissues - higher background., IHC, ICC, IP, FC, ELISA. Antigen retrieval pretreatment is not necessary on paraffin embedded tissue sections. Especially useful for working with rodents tissues. Lower background in tissue staining. Humanization Possible but low homology to human germline sequence. An excellent starting point for humanization: Higher homology to human germline sequence. Table 1. Advantages of rabbit monoclonal service over mouse monoclonal service. Contact us to discuss your custom antibody needs or schedule a presentation about our technology and services. Phone: 877-7RABMAB ( ) (Toll Free in North America) [email protected] Online Custom Service Request Form Table 2. Overview of Epitomics Rabbit Monoclonal Service.

35 Rabbit Monoclonal Antibodies - Spring 2010 The R abbit M ono clonal Company 863 Mitten Rd. Suite 103 Burlingame, CA Inside: Actin Adducin AFP AIF Akt1 Aldh1A1 Alk Amphipysin AMPK APP Androgen Receptor Apaf1 APC Apo E ARF1 Arrestin 1 ASK1 Asparagine Synthetase ATF2 Atg7 ATM ATP-citrate lyase Aurora A Aurora B Aurora C B7-1 Bad Bag-1 Bak Bax Bcl-2 Bcl-6 Bcl-10 Bcl-x Bcr BDNF Beclin-1 Arrestin Catenin Synuclein Tubulin Bid Bim BIR3 BLNK Myc Btk C/EBP C-Abl CAD Cadherin Calcitonin Caldesmon Over Calponin 1600 Calretinin Rabbit CaMKI Monoclonal Casein Kinase Antibodies Caspases (RabMAbs Catalase Catenin ) and related Caveolin-1 products Cbl CCL4 CCR2 CCR7 CCR9 CD11a CD11b CD20 CD22 CD3 CD5 CD8 CD34 CD40 Ligand CD45 CD80 CD86 Cdc2 Cdc25c Cdk2 Cdk5 CENP-A Chk1 Chk2 Chromogranin New Antibodies A c-jun Cytokeratin and Kits 8/18 - BioActive C-myc cortactin Antibodies, Cox2 ELISA c-product Kits Creb Crk CrkL Cyclin A2 Cyclin B1 Cyclin D1 Cyclin E1 Cyclin Rabbit E2 Cytochrome Monoclonal C Cytokeratin Vs. Mouse 4 Cytokeartin Monoclonal 5 Cytokeratin Comparison 6 Cytokeratin 14 Cytokeratin 29 Cytokeratin 20 DAP-1 DAPK2 DAPK3 Custom DARPP-32 Antibody Daxx Service Desmin Diablo Dsh-3 Dynamin-1 Dystroglycan E-cadherin eef2 EGFR eif2a eif4e eif5a Elk1 EMSY EMTK Endo G EphA3 Ep-CAM Estrongen Receptor ErbB Erk1 Erk2 Erk3 Estrongen Related Receptor Etk Ezh1 Ezh2 Ezrin FADD FAK FAK2 Fc gamma RIIb Fer FGFR-1 Fibronectin FKHR Flotillin-1 Flt3-L FOXO3a FRAP Fyn Gab1 Gab2 Synuclein GAP43 GCDFP15 Gelsolin GFAP GFP GluR1 GluR2 GluR3 Glutathione Glycodelin Glycogen Synthase GM130 GOS-28 GRB2 GRK2 GRP1 GSK3 Gstk1 Hamartin Heme Oxygenase 1 Her2 Her3 Her4 HIAP-1 HIF-1 Histone H2 Histone H3 Histone H4 HIV-p24 hnrnpk HoxB4 HPK1 H-Ras HSD17B1 HSF1 c-jun HSF4 HSP27 HSP60 HSP70 HSP73 HSP90 htert HtrA2 Huntingtin ICAM-1 IDO IFN Alpha IFN Gamma IGBP1 IKK Alpha IKK Beta IL-1 IL-1R IL-3R IL-4 IL-6 IL-10 ILK IHH INSR Integrin IRAK-3 IRAK-4 IRS-1 IRS-2 IRS-3 ITAM ITGB1 ITGB2 ITK Jak2 Jak3 JAM1 JNK2 JNK3 KDR Ki-67 Kv4.2 LBR LAT LCAT Lck LDH-A LDH-B LDH-C LDL Receptor LEF-1 LFA-1a Lyn MAG MALT1 MAPILC3A MAPKAP Kinase-2 TNF Beta MARK3 MART1 MBP Mcl-1 MCM7 MCP-1 M-CSF MEF2A MEK1 MEK2 MEKK2 MEKK3 MEKK4 MEKK5 MerTK Met MHC Class I Midkine MIP-1 MKK3 MKK4 MKK5 MKK6 MKK7 MKP3 MLCK MLK3 MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-11 ER Alpha MMP-13 MMP-14 MMP-17 MMP-20 MMP-21 MMP-26 Mo25 Moesin SMAD1 MSK1 Mst1 Mst2 Mst3 Mst4 mtor MUC1 Musashi-1 Her2 MYPT1 MYPT2 NAK NCK NF-66 NF-L NF-KappaB NGF Nibrin inos Noggin Notch-1 NPM Nrf2 Oct-2 Op18 p16 P21 P27 p38 p40 p44 p53 p58 p70 p73 p80 p120 p130 PAEP PAK1 PAK2 PAK3 PAK4 Parkin PARP-1 PARP-2 Paxillin PDGFR PDK1 PDK2 PI3- Kinase p85 subunit PI3-Kinase p110 subunit Pin1 PKA PKC PKR PLAP PLC Beta II PLC Gamma II Plectin Pol II PEG Pou Domain Protein 3A PP1 PP2A PP2B PRA1 PRC1 Presenilin Presenilin 2 Prion Prtein PRK2 PR PSA PTEN PTP1B PUMA Pyk2 Radixin Raf-1 RAIDD RanBP9 RANTES Rap1 CK 18 Raptor RAR Ras RasGap Rb Rb2 RelB Rho EGFR Ron Rsk1 Rsk2 Rsk3 CDX2 S100 Beta SCF SEK Serum Amyloid P-compoent SGK SHC1 SHH SHP-1 SHP-2 SIRT1 SIRT2 Smac Smad1 Smad2 Smad3 Smad4 Smad5 Smurf2 SOD1 SR-B1 Scavenge Receptor Src Stat-1 Stat-2 Stat-3 Stat-5 Stat- 6 Stathmin SUMO-1 SoF Syk Synapsin I Synaptophysin Synip Synuclein Alpha Synuclein Beta TAB1 Tau TBK1 TC10 TCF-1 TCF-4 TEC TGIF TIMP-1 TIRAP TNF Alpha TNF Beta Topo II Alpha Tp12 TRAP3 TRAP6 TRAP cleavage TrkB Phospho Troponin 1 TRPC1 TPH1 TSC1 E-Cadherin TSC2 Tubulin Alpha Tubulin Beta Tyk2 Tyrosinase Tyrosine 3-Hydroxylase UBC-1 Ubiquitin Vav Vav2 Vav3 VEGF VEGFR-1 VEGFR-2 Vimentin Vitronectin VLA Alpha 4 WSTF YAP65 ZAP-70 Contact Epitomics: PH: FAX: [email protected] [email protected] [email protected] Copyright , Epitomics, Inc. All rights reserved. Epitomics and RabMAb are registered trademarks of Epitomics, Inc. SP10