Introduction to Mendelian Genetics and Mendel s Three Laws

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1 Use the back of the sheet if you run Run out of room on the front! Use the boxes for your Cornell notes. Name: Date: Period: Introduction to Mendelian Genetics and Mendel s Three Laws Mendelian laws of inheritance are statements about the way certain characteristics are transmitted from one generation to another in an organism. The laws were derived by the Austrian monk Gregor Mendel ( ) based on experiments he conducted in the period from about 1857 to For his experiments, Mendel used ordinary pea plants. Among the traits that Mendel studied were the color of a plant's flowers, their location on the plant, the shape and color of pea pods, the shape and color of seeds, and the length of plant stems. v READING CHECK: What are laws of inheritance? v READING CHECK: What type of plants did Mendel study? v READING CHECK: Give two examples of traits Mendel studied with his pea plants. Mendel's approach was to transfer pollen (which contains male sex cells) from the stamen (the male reproductive organ) of one pea plant to the pistil (female reproductive organ) of a second pea plant. As a simple example of this kind of experiment, suppose that one takes pollen from a pea plant with red flowers and uses it to fertilize a pea plant with white flowers. What Mendel wanted to know is what color the flowers would be in the offspring of these two plants. In a second series of experiments, Mendel studied the changes that occurred in the second generation. That is, suppose two offspring of the red/white mating ("cross") are themselves mated. What color will the flowers be in this second generation of plants? As a result of these experiments, Mendel was able to state three generalizations about the way characteristics are transmitted from one generation to the next in pea plants.

2 Words to Know v Allele: One of two or more forms a gene may take. v Dominant: An allele whose expression overpowers the effect of a second form of the same gene. v Gamete: A reproductive cell. v Heterozygous: A condition in which two alleles for a given gene are different from each other. v Homozygous: A condition in which two alleles for a given gene are the same. v Recessive: An allele whose effects are concealed in offspring by the dominant allele in the pair. Terminology Before reviewing these three laws, it will be helpful to define some of the terms used in talking about Mendel's laws of inheritance. Most of these terms were invented not by Mendel, but by biologists some years after his research was originally published. Genes are the units in which characteristics are passed from one generation to the next. For example, a plant with red flowers must carry a gene for that characteristic. A gene for any given characteristic may occur in one of two forms, called the alleles (pronounced uh-leelz) of that gene. For example, the gene for color in pea plants can occur in the form (allele) for a white flower or in the form (allele) for a red color. The first step that takes place in reproduction is for the sex cells in plants to divide into two halves, called gametes. The next step is for the gametes from the male plant to combine with the gametes of the female plant to produce a fertilized egg. That fertilized egg is called a zygote. A zygote contains genetic information from both parents. For example, a zygote might contain one allele for white flowers and one allele for red flowers. The plant that develops from that zygote would said to be heterozygous for that trait since its gene for flower color has two different alleles. If the zygote contains a gene with two identical alleles, it is said to be homozygous.

3 Mendel's laws Mendel's law of segregation describes what happens to the alleles that make up a gene during formation of gametes. For example, suppose that a pea plant contains a gene for flower color in which both alleles code for red. One way to represent that condition is to write RR, which indicates that both alleles (R and R) code for the color red. Another gene might have a different combination of alleles, as in Rr. In this case, the symbol R stands for red color and the r for "not red" or, in this case, white. Mendel's law of segregation says that the alleles that make up a gene separate from each other, or segregate, during the formation of gametes. That fact can be represented by simple equations, such as: RR R + R or Rr R + r

4 Mendel's second law is called the law of independent assortment. That law refers to the fact that any plant contains many different kinds of genes. One gene determines flower color, a second gene determines length of stem, a third gene determines shape of pea pods, and so on. Mendel discovered that the way in which alleles from different genes separate and then recombine is unconnected to other genes. That is, suppose that a plant contains genes for color (RR) and for shape of pod (TT). Then Mendel's second law says that the two genes will segregate independently, as: RR R + R and TT T + T Predicting traits Mendel's third law deals with the matter of dominance. Suppose that a gene contains an allele for red color (R) and an allele for white color (r). What will be the color of the flowers produced on this plant? Mendel's answer was that in every pair of alleles, one is more likely to be expressed than the other. In other words, one allele is dominant and the other allele is recessive. In the example of an Rr gene, the flowers produced will be red because the allele R is dominant over the allele r. The application of Mendel's three laws makes it possible to predict the characteristics of offspring produced by parents of known genetic composition. Biologists have discovered that Mendel's laws are simplifications of processes that are sometimes much more complex than the examples given here. However, those laws still form an important foundation for the science of genetics.

5 READING CHECK: Does Mendel s first law address gamete (sex cell) formation or fertilization? READING CHECK: What does Mendel s first law of inheritance say? READING CHECK: What does Mendel s second law of inheritance say? READING CHECK: What does Mendel s third law of inheritance say?