Genetics of Plant-Pathogen Interactions (Plant Immunity) Topics on Systemic Acquired Resistance (SAR)
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1 Genetics of Plant-Pathogen Interactions (Plant Immunity) Topics on Systemic Acquired Resistance (SAR)
2 Host vs. Nonhost
3 Basic fact: In nature, most plants are healthy most of the time. If disease occurs, it is actually restricted to a few plants and affects only small amount of tissue. Most plants are resistant to most pathogens, so disease is the exception. Plants that cannot be successfully attacked by a given pathogen are called nonhosts for that pathogen.
4 Major types of plant pathogens: - Bacteria - Fungi (>80% loss) - Viruses - Viroid Pathogenesis: Process of infection, colonization, and reproduction Pathogenecity: Ability to cause disease Virulence: severity of disease Plants defense systems: - Preformed (nonhost) - Activated or induced
5 Disease symptoms Signs of disease
6 noble rot sweet dessert wines Sauternes Château d'yquem
7 Corn smut Huitlacoche in Mexico (Mexican truffle) From J. Kronstad
8 Activated plant defense systems - Local responses - Systemic responses (SAR)
9 Local responses: hypersensitive reaction (HR) HR is a pattern of localized cell death within the plant tissue at the site of infection. This local cell death blocks pathogen growth by depriving biotrophic pathogens of nutrition, and by creating a highly oxidizing environment that damages proteins and cell structures.
10 Systemic acquired resistance (SAR) Systemic resistance???? Necrosis?? Local HR
11 Systemic acquired resistance (SAR) Later No previous virus infection Early in growth season Blue mold of tobacco Ross, 1960s
12
13 Systemic acquired resistance (SAR) Systemic resistance???? Necrosis?? Local HR
14 1990s, Métraux and Ryals groups
15 Is SA a signal molecule for SAR? How would you test it? Systemic resistance PR gene expression SA? Local infection Necrosis SA
16 Is SA a signal molecule for SAR? Test for sufficiency: Is SA sufficient to induce SAR? Test for necessity: Is SA required for SAR? 1979, White
17 Effects of 200 μm salicylic acid (SA) treatments and inoculation of Fusarium oxysporum f. sp. lycopersici (Fol) on hydroponically grown tomato. (a) Vascular browning; (b) Leaf yellowing wilting. From: Plant Physiology and Biochemistry Volume 47, Issue 7, July 2009, Pages
18 WT NahG NahG: salicylate hydroxylase from Pseudomonas fluorescens NahG SA hydroxylase NADH+O 2 NAD+H 2 O+CO 2
19 Will SA save the day?
20 Ryals group, Novartis Actiguard TM
21 Systemic acquired resistance (SAR) Systemic resistance SA? Necrosis SA Local infection
22
23
24 Major PR proteins PR-1: cysteine-rich proteins, with antifungal activity PR-2 (ß glucanases, BGL2): have (1,3)-endoglucanase activity in vitro PR-3 (chitinases) PR-4 (chitin-binding) proteins: have potent antifungal activity PR-5 (TL): thaumatin like proteins, sweet tasting, stable structure, resistant to protease degradation, may affect membrance permeability
25 Can we enhance general disease resistance to pathogens by overexpressing PR genes? Systemic resistance PR gene expression SA? Necrosis SA Local infection
26 What is the mobile signal for SAR? Is SA the mobile signal? Systemic resistance PR gene expression SA? Necrosis SA Local infection
27 Is SA the mobile signal for SAR? CMV TMV
28 References: Buchanan et al Biochemistry and molecular biology of plants. ASPP, Rockville, MD. Chapter 21. Terrence P. Delaney. Salicylic acid Chapter.
29 Summary on what we learned about SAR 1. SAR is a pathogen-induced defense response against broad-spectrum of pathogens. 2. PR genes are highly induced during SAR. They are used as molecular markers for defense responses. 3. SA level increases locally and systemically during SAR. 4. SA is required for SAR. 5. SA and its analogs are sufficient to induce SAR. 6. SA is most likely not the mobile signal for SAR. 7. Overexpression of a single PR gene is not sufficient to establish SAR. Systemic resistance PR gene expression SA? Local infection Necrosis SA
30 Systemic resistance PR gene expression? SA?? Local infection Necrosis? SA
31 Proposing experiments to address questions on SAR Hint: For each step in a signaling pathway, there are (almost always) not only positive regulators, but also negative regulators. Think about what kinds of phenotypes you would expect for l-o-f mutants of those regulators before you design a genetic screen.
32 Proposing experiments to study SAR Question or hypothesis Proposed experiments Expectations Does Arab has SAR? SAR Yes What is making SA? Find low SA mutants? Find SA synthesis enzymes What is the mobile signal? No SA in distal leaves What s downstream of SA? Sa spray, then no SRA mutants Negative regulator of SAR constitutive SAR
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