Functional magnetic resonance imaging in multiple sclerosis patients with fatigue before and after neurorehabilitation therapy

Save this PDF as:
 WORD  PNG  TXT  JPG

Size: px
Start display at page:

Download "Functional magnetic resonance imaging in multiple sclerosis patients with fatigue before and after neurorehabilitation therapy"

Transcription

1 Functional magnetic resonance imaging in multiple sclerosis patients with fatigue before and after neurorehabilitation therapy Poster No.: C-2496 Congress: ECR 2010 Type: Topic: Authors: Keywords: DOI: Scientific Exhibit Neuro M. Ukmar, E. Trincia, M. Naccarato, M. Catalan, S. Mezzarobba, M. A. Cova; Trieste/IT fmri, multiple sclerosis, fatigue /ecr2010/C-2496 Any information contained in this pdf file is automatically generated from digital material submitted to EPOS by third parties in the form of scientific presentations. References to any names, marks, products, or services of third parties or hypertext links to thirdparty sites or information are provided solely as a convenience to you and do not in any way constitute or imply ECR's endorsement, sponsorship or recommendation of the third party, information, product or service. ECR is not responsible for the content of these pages and does not make any representations regarding the content or accuracy of material in this file. As per copyright regulations, any unauthorised use of the material or parts thereof as well as commercial reproduction or multiple distribution by any traditional or electronically based reproduction/publication method ist strictly prohibited. You agree to defend, indemnify, and hold ECR harmless from and against any and all claims, damages, costs, and expenses, including attorneys' fees, arising from or related to your use of these pages. Please note: Links to movies, ppt slideshows and any other multimedia files are not available in the pdf version of presentations. Page 1 of 9

2 Purpose Fatigue is a common symptom in patients with multiple sclerosis (MS), reported in over 80% of cases and associated with a high degree of disability and a reduced quality of life [1]. The pathogenesis of fatigue in MS is still unclear, but electrophysiological and neuroimaging studies recently supported a central origin. In fact, fatigue may be correlated to motor dysfunction of circuits involving the thalamus, the basal ganglia and the frontal cortex [2,3,4]. Moreover in MS patient the f-mri demonstrates an abnormal cortical and subcortical activation while performing a nmotor task, due to functionally adaptive changes as a consequence of white and gray matter [4,5,6]. Rehabilitation treatment could modify this activation [7]. According to the evidence that fatigue is the consequence of motor planning and execution dysfunction we supposed that a specific neurorehabilitation therapy could modify the cortical activation reducing the fatigue symptoms. The aim of our study was to evaluate the pattern of activation during a motor task by f-mri in patients with MS and fatigue, without motor impairment, before and after neurorehabilitation therapy. Methods and Materials In our study we enorolled 10 female patients right handed, with relapsing-remitting MS and fatigue. The mean age was years (range years) and the mean disease duration was 5 years (range 2-10 years). EDSS (Expanded Disability Status Scale) score was low (<3.5). The fatigue score was measured by Fatigue Severity Scale (FSS) and was higher than 4.5 points. Criteria for excluding patients were ongoing clinical relapse, major depression, cognitive impairment, traeatment with immunosupressive drugs, and common contraindication to MR examination. All MR examination were performed by using 1.5 T magnet: SE PD/T2 weighted and FLAIR sequences were performed in order to calculate the lesion load. The functional evaluation was performed by an EPI sequence (TR/TE=2158/ 45 msec, 25 slices, 4 mm, no gap, 160 dynamics) during the execution of a simple finger tapping task with the right hand. Page 2 of 9

3 The neurological evaluation (disability, fatigue) and the MR examination were performed before and after the neurorehabilitation therapy. This therapy lasted three months and consisted of exercises in order to modify specifically cognitive processes during movement planning and subsequently movement control. The statistical analysis concerning disability and fatigue scale was performed using non parametric Wilcoxon test. The lesion load was calculated by using the software Analyze 5. The functional data were processed using the SPM package version 2. Single subjects SPM-maps were generated (p<0.001 corrected for multiple comparisons). Then a group analysis was performed comparing activations maps of patients before and after treatment (p<0.05 corrected for multiple comparisons). The statistical analysis, concerning functional evaluation, was performed by using Student's t-test. Results After treatment, a significant decrease in fatigue scale (FSS) was detected, while no differences were detected in disability scores (tab.1). Baseline mean±sd Follow-up mean±sd p EDSS 1.63± ±0.37 ns FSS 5.56± ± TAB: 1- Clinical evaluation before and after treatment EDSS: expanded disability status scale FSS: fatigue severity scale No differences were found regarding the total lesion load (tab.2). pre post p Page 3 of 9

4 T2 Lesion load 4.24± ±4.96 ns TAB. 2: Conventional MRI: Lesion load before and after treatment The fmri analysis performed after neurorehabilitation therapy showed a reduction in activations of both bilateral sensorimotor cortex, mainly the ipsilateral one, cerebellum and thalami (p<0.05) (Fig. 1A-B) on page 5 (Fig. 2). on page 5 Fig.: Fig 1 A-B: f-mri - cortical activation before (A) and after neurorehabiliation therapy (B). After therapy there are a reduced activation mainly in the ipsilateral sensori-motor area and in the cerebellum bilaterally. References: M. Ukmar; Department of Radiology, University of Trieste, Trieste, ITALY Page 4 of 9

5 Images for this section: Fig. 1: Fig 1 A-B: f-mri - cortical activation before (A) and after neurorehabiliation therapy (B). After therapy there are a reduced activation mainly in the ipsilateral sensori-motor area and in the cerebellum bilaterally. Page 5 of 9

6 Page 6 of 9

7 Fig. 2: Fig 2: f-mri - Pre vs post treatment analysis: reduction in activation of thalami after rehabilitation treatment. Page 7 of 9

8 Conclusion Our results confirm that there is an abnormal activation during the execution of a motor task in patients with MS and fatigue. Neurorehabilitation therapy could reduce the grade of fatigue improving the quality of life of the patients by modifying cortical and subcortical activation. The fmri could be an objective tool to evaluate the efficacy of rehabilitation treatment in MS patients with fatigue. References 1) Krupp LB, Alvarez LA, LaRocca NG, Scheinberg LC (1988) Clinical characteristics of fatigue in multiple sclerosis. Arch Neurol. 45: ) Filippi M, Rocca MA, Colombo B, Falini A, Codella M, Scotti G, Comi G. (2002) Functional magnetic resonance imaging correlates of fatigue in multiple sclerosis. Neuroimage 15: ) De Luca J, Genova HM, Hillary FG, Wylie G (2008) Neural correlates of cognitive fatigue in multiple sclerosis using functional MRI. Journal Neurol Sci 270: ) Tartaglia MC, Narayanan S, Arnold DL (2008) Mental fatigue alters the pattern and increase the volume of cerebral activation required for a motor task in multiple sclerosis patients with fatigue. Eur J Neurol 15: Page 8 of 9

9 5) Rocca MA, Filippi M (2007) Functional MRI in multiple sclerosis. J neuroimaging 17: 36S-41S. 6) Lee M, Reddy H, Johansen-Berg H, Pendlebury S, Jenkinson M, Smith S, Palace J, Matthews PM (2000) The motor cortex shows adaptive functional changes to brain injury from multiple sclerosis. Ann Neuro 47: ) Carey LM, Seitz RJ: Functional neuroimaging in stroke recovery and neurorehabilitation: conceptual issues and perspectives (2007) Int J Stroke 2: Personal Information Maja Ukmar, MD Department of Radiology University of Trieste Italy Page 9 of 9

OA related pain medication intake in subjects from the OAI incidence cohort - association with focal knee lesions and cartilage T2 measurements

OA related pain medication intake in subjects from the OAI incidence cohort - association with focal knee lesions and cartilage T2 measurements OA related pain medication intake in subjects from the OAI incidence cohort - association with focal knee lesions and cartilage T2 measurements Poster No.: C-0007 Congress: ECR 2012 Type: Scientific Exhibit

More information

Utilization management for successful process optimization in radiology

Utilization management for successful process optimization in radiology Utilization management for successful process optimization in radiology Poster No.: C-0737 Congress: ECR 2011 Type: Scientific Paper Authors: H.-P. Busch 1, W. Frewer 1, A. van Est 2 ; 1 Trier/DE, 2 Eindhoven/NL

More information

CT findings in Differential Diagnosis between Tuberculous Pleurisy and Malignant Effusion

CT findings in Differential Diagnosis between Tuberculous Pleurisy and Malignant Effusion CT findings in Differential Diagnosis between Tuberculous Pleurisy and Malignant Effusion Poster No.: E-0084 Congress: ESTI 2012 Type: Scientific Exhibit Authors: S. S. Shim, Y. Kim; Seoul/KR Keywords:

More information

Learning objectives. Background. Imaging findings OR Procedure details

Learning objectives. Background. Imaging findings OR Procedure details A comparison of limited MRI of the axial skeleton (lumbar spine and pelvic bones) with whole body bone scintigraphy in detecting bone metastasis from prostate carcinoma Poster No.: C-659 Congress: ECR

More information

Interactive radiology tutorials - self made!

Interactive radiology tutorials - self made! Interactive radiology tutorials - self made! Poster No.: C-1129 Congress: ECR 2013 Type: Educational Exhibit Authors: R. Talanow; Lincoln, CA/US Keywords: Computer applications, Anatomy, Image manipulation

More information

Diffuse infiltration in multiple myeloma treatment response assessment with "total-spine" contrast enhanced MR imaging

Diffuse infiltration in multiple myeloma treatment response assessment with total-spine contrast enhanced MR imaging Diffuse infiltration in multiple myeloma treatment response assessment with "total-spine" contrast enhanced MR imaging Poster No.: C-0276 Congress: ECR 2011 Type: Scientific Paper Authors: P. P. Arcuri,

More information

Patterns of nodal spread in thoracic malignancies

Patterns of nodal spread in thoracic malignancies Patterns of nodal spread in thoracic malignancies Poster No.: C-0977 Congress: ECR 2010 Type: Educational Exhibit Topic: Chest Authors: R. dos Santos, M. Duarte, J. Alpendre, J. Castaño, Z. Seabra, Â.

More information

Determination of bone age using MRI of hand/wrist: a pilot study

Determination of bone age using MRI of hand/wrist: a pilot study Determination of bone age using MRI of hand/wrist: a pilot study Poster No.: C-0963 Congress: ECR 2011 Type: Scientific Exhibit Authors: E. Tomei, M. Marini, A. Stagnitti, A. sartori, L. bertana, N. Al

More information

A new dynamic technique for assessing acromio-clavicular joint instability with ultrasound

A new dynamic technique for assessing acromio-clavicular joint instability with ultrasound A new dynamic technique for assessing acromio-clavicular joint instability with ultrasound Poster No.: C-596 Congress: ECR 2009 Type: Educational Exhibit Topic: Musculoskeletal Authors: P. Peetrons; Brussels/BE

More information

Superiority of multi-energy color X-ray for breast specimen radiography.

Superiority of multi-energy color X-ray for breast specimen radiography. Superiority of multi-energy color X-ray for breast specimen radiography. Poster No.: C-2119 Congress: ECR 2011 Type: Scientific Exhibit Authors: I. Willekens 1, B. Dierickx 2, N. Buls 3, C. Breucq 4, A.

More information

An Image Based Semiautomatic Online Cancer Staging Program for Common Female Pelvic Malignancies

An Image Based Semiautomatic Online Cancer Staging Program for Common Female Pelvic Malignancies An Image Based Semiautomatic Online Cancer Staging Program for Common Female Pelvic Malignancies Poster No.: C-1050 Congress: ECR 2012 Type: Educational Exhibit Authors: R. Talanow; Lexington, KY/US Keywords:

More information

Comparison of radiation dose from X-ray, CT, and PET/ CT in paediatric patients with neuroblastoma using a dose monitoring program

Comparison of radiation dose from X-ray, CT, and PET/ CT in paediatric patients with neuroblastoma using a dose monitoring program Comparison of radiation dose from X-ray, CT, and PET/ CT in paediatric patients with neuroblastoma using a dose monitoring program Poster No.: C-0591 Congress: ECR 2015 Type: Authors: Keywords: DOI: Scientific

More information

Preoperative evaluation of future remnant liver function by the contrast enhance ratio in hepatocellular image.

Preoperative evaluation of future remnant liver function by the contrast enhance ratio in hepatocellular image. Preoperative evaluation of future remnant liver function by the contrast enhance ratio in hepatocellular image. Poster No.: C-0564 Congress: ECR 2011 Type: Scientific Exhibit Authors: S. Matsushima, Y.

More information

Eye lens dose measurements in Interventional Cardiology

Eye lens dose measurements in Interventional Cardiology Eye lens dose measurements in Interventional Cardiology Poster No.: 479 Congress: ESCR 2014 Type: Scientific Poster Authors: N. Kollaros 1, E. Carinou 2, C. Plemmenos 1, I. Stathopoulos 1, V. Keywords:

More information

Diffusion-weighted MR imaging in lymphadenopathy for differentiation of malignant lymphoma, metastatic lymph node and benign lymphadenopathy

Diffusion-weighted MR imaging in lymphadenopathy for differentiation of malignant lymphoma, metastatic lymph node and benign lymphadenopathy Diffusion-weighted MR imaging in lymphadenopathy for differentiation of malignant lymphoma, metastatic lymph node and benign lymphadenopathy Poster No.: R-0089 Congress: RANZCR-AOCR 2012 Type: Scientific

More information

MRI scanning of the claustrophobic patients

MRI scanning of the claustrophobic patients MRI scanning of the claustrophobic patients Poster No.: C-0549 Congress: ECR 2014 Type: Educational Exhibit Authors: M. minov, A. Doreski, M. Popovska, G. Markoski, S. 1 2 3 2 2 1 2 2 3 Jovanoska, I. miladinovski

More information

Development and implementation of a help desk system in a radiology department in a high complexity hospital: a South American experience

Development and implementation of a help desk system in a radiology department in a high complexity hospital: a South American experience Development and implementation of a help desk system in a radiology department in a high complexity hospital: a South American experience Poster No.: C-2409 Congress: ECR 2013 Type: Authors: Keywords:

More information

We developed and evaluated an alternative cloud-based diagnostic image viewing and storage system we call LOOKREC

We developed and evaluated an alternative cloud-based diagnostic image viewing and storage system we call LOOKREC Cloud-based diagnostic image viewer and storage system: Evaluation of image transaction speed and monthly storage costs in comparison with conventional off-internet system. Poster No.: C-0095 Congress:

More information

Pancreatic masses: What is there besides cancer

Pancreatic masses: What is there besides cancer Pancreatic masses: What is there besides cancer Poster No.: C-0201 Congress: ECR 2010 Type: Educational Exhibit Topic: Abdominal Viscera (Solid Organs) Authors: M. A. Portilha, C. Ruivo, I. Santiago, M.

More information

Needle crystal detector technology in mammography further dose reduction and clinical image quality with

Needle crystal detector technology in mammography further dose reduction and clinical image quality with Needle crystal detector technology in mammography further dose reduction and clinical image quality with different beam qualities (W/Rh vs. Mo/Rh) Poster No.: C-1461 Congress: ECR 2013 Type: Scientific

More information

Acute abdominal pain in the elderly patient: Impact of early MDCT examination on diagnosis and management

Acute abdominal pain in the elderly patient: Impact of early MDCT examination on diagnosis and management Acute abdominal pain in the elderly patient: Impact of early MDCT examination on diagnosis and management Poster No.: C-1464 Congress: ECR 2010 Type: Topic: Scientific Exhibit GI Tract Authors: A. Pinto,

More information

Economic analysis of a mutualized regional PACS solution vs a hospital-based stand-alone PACS solution

Economic analysis of a mutualized regional PACS solution vs a hospital-based stand-alone PACS solution Economic analysis of a mutualized regional PACS solution vs a hospital-based stand-alone PACS solution Poster No.: C-1254 Congress: ECR 2013 Type: Scientific Exhibit Authors: A. KHELIFA 1, J.-C. Dron 1,

More information

Normal vascular variants of the upper extremity

Normal vascular variants of the upper extremity Normal vascular variants of the upper extremity Poster No.: C-1039 Congress: ECR 2014 Type: Educational Exhibit Authors: P. Paixao, A. P. Gomes, M. S. C. Sousa, I. Santiago, A. S. C. C. Germano; Amadora/PT

More information

Ultrasound findings in the skin and subcutaneous tissue of the breast

Ultrasound findings in the skin and subcutaneous tissue of the breast Ultrasound findings in the skin and subcutaneous tissue of the breast Poster No.: C-1431 Congress: ECR 2012 Type: Educational Exhibit Authors: I. Quintana 1, L. Martinez Comín 1, C. Garcia Mur 1, A. Alconchel

More information

DICOM metadata-mining in PACS for computed radiography X-Ray exposure analysis: a mammography multisite study

DICOM metadata-mining in PACS for computed radiography X-Ray exposure analysis: a mammography multisite study DICOM metadata-mining in PACS for computed radiography X-Ray exposure analysis: a mammography multisite study Poster No.: B-0276 Congress: ECR 2014 Type: Authors: Keywords: DOI: Scientific Paper M. R.

More information

Paediatric Knee Radiographs: Normal Appearances of the Knee Joint in the Growing Patient

Paediatric Knee Radiographs: Normal Appearances of the Knee Joint in the Growing Patient Paediatric Knee Radiographs: Normal Appearances of the Knee Joint in the Growing Patient Poster No.: P-0124 Congress: ESSR 2015 Type: Educational Poster Authors: C. Chisholm, D. Mak, M. Thyagarajan; Birmingham/UK

More information

Metastatic malignant melanoma revisited

Metastatic malignant melanoma revisited Metastatic malignant melanoma revisited Poster No.: C-2446 Congress: ECR 2010 Type: Educational Exhibit Topic: Musculoskeletal Authors: C. Paulino, B. Gonçalves, P. Marques, M. Gonçalo, F. CaseiroAlves;

More information

Angio-CT preoperative planning of inferior limb free flaps in plastic surgery

Angio-CT preoperative planning of inferior limb free flaps in plastic surgery Angio-CT preoperative planning of inferior limb free flaps in plastic surgery Poster No.: C-3046 Congress: ECR 2010 Type: Educational Exhibit Topic: Vascular Authors: L. Saba, M. Atzeni, D. Ribuffo, G.

More information

Role of 3D volumetry CT in the correlation between postoperative gastric volume and weight loss in obese patients undergoing gastric sleeve surgery.

Role of 3D volumetry CT in the correlation between postoperative gastric volume and weight loss in obese patients undergoing gastric sleeve surgery. Role of 3D volumetry CT in the correlation between postoperative gastric volume and weight loss in obese patients undergoing gastric sleeve surgery. Poster No.: C-2145 Congress: ECR 2014 Type: Scientific

More information

MULTIMODAL THERAPY FOR MS- ASSOCIATED COGNITIVE DYSFUNCTION

MULTIMODAL THERAPY FOR MS- ASSOCIATED COGNITIVE DYSFUNCTION MULTIMODAL THERAPY FOR MS- ASSOCIATED COGNITIVE DYSFUNCTION Michael K. Racke, MD Professor and Chairman in Neurology The Helen C. Kurtz Chair in Neurology Department of Neurology Ohio State University

More information

Cognitive rehabilitation in MS

Cognitive rehabilitation in MS 14th MS Nurse International Workshop Lyon, France, October 9th 2012 Cognitive and psychological issues in MS Cognitive rehabilitation in MS Psychological Unit Neurological Department San Raffaele Hospital

More information

Spinal stenosis and lumbar disc pathology: what every radiologist should know.

Spinal stenosis and lumbar disc pathology: what every radiologist should know. Spinal stenosis and lumbar disc pathology: what every radiologist should know. Poster No.: C-1301 Congress: ECR 2011 Type: Authors: Educational Exhibit A. Ovelar Ferrero 1, N. Alvarez de Eulate León 2,

More information

Clinical Study Synopsis

Clinical Study Synopsis Clinical Study Synopsis This file is posted on the Bayer HealthCare Clinical Trials Registry and Results website. It is provided for patients and healthcare professionals to increase the transparency of

More information

Simple ovarian cysts in pre and post menopausal women: what, where and when.

Simple ovarian cysts in pre and post menopausal women: what, where and when. Simple ovarian cysts in pre and post menopausal women: what, where and when. Award: Certificate of Merit Poster No.: C-1438 Congress: ECR 2012 Type: Educational Exhibit Authors: R. A. Gray, S. Higgins,

More information

Accuracy of Preoperative Estimation of Breast Carcinoma Size Using B-mode Ultrasound and Ultrasound Elastography.

Accuracy of Preoperative Estimation of Breast Carcinoma Size Using B-mode Ultrasound and Ultrasound Elastography. Accuracy of Preoperative Estimation of Breast Carcinoma Size Using B-mode Ultrasound and Ultrasound Elastography. Poster No.: C-1796 Congress: ECR 2014 Type: Scientific Exhibit Authors: S. M. Idrus Alhabshi;

More information

Differential diagnosis of vertebral compression fracture using in-phase/opposed-phase and Short TI inversion recovery imaging

Differential diagnosis of vertebral compression fracture using in-phase/opposed-phase and Short TI inversion recovery imaging Differential diagnosis of vertebral compression fracture using in-phase/opposed-phase and Short TI inversion recovery imaging Poster No.: C-0795 Congress: ECR 2013 Type: Scientific Exhibit Authors: A.

More information

Second look ultrasound examination for breast lesions: MRI and pathologic correlation

Second look ultrasound examination for breast lesions: MRI and pathologic correlation Second look ultrasound examination for breast lesions: MRI and pathologic correlation Poster No.: C-0559 Congress: ECR 2015 Type: Scientific Exhibit Authors: E. Serrano Tamayo, E. López Soriano, M. Muñoz

More information

Fatigue in MS: 2005 update B. Colombo University of Milan - HSR

Fatigue in MS: 2005 update B. Colombo University of Milan - HSR Fatigue in MS: 2005 update B. Colombo University of Milan - HSR Fatigue in MS One of the more disabling symptoms Affects about 75/90 % of the patients May be the onset symptom Transient or chronic May

More information

Comparison between photoacoustic mammography images of breasts cancers and histological staining patterns of CD31 and carbonic anhydrase IX

Comparison between photoacoustic mammography images of breasts cancers and histological staining patterns of CD31 and carbonic anhydrase IX Comparison between photoacoustic mammography images of breasts cancers and histological staining patterns of CD31 and carbonic anhydrase IX Poster No.: C-1893 Congress: ECR 2013 Type: Scientific Exhibit

More information

Tears at the rotator cuff footprints: imaging characteristic on MRI and ultrasound, evolutions and clinical significance

Tears at the rotator cuff footprints: imaging characteristic on MRI and ultrasound, evolutions and clinical significance Tears at the rotator cuff footprints: imaging characteristic on MRI and ultrasound, evolutions and clinical significance Poster No.: C-0521 Congress: ECR 2012 Type: Authors: Keywords: DOI: Scientific Paper

More information

Montreal Cognitive Assessment (MoCA) as Screening tool for cognitive impairment in mtbi.

Montreal Cognitive Assessment (MoCA) as Screening tool for cognitive impairment in mtbi. Montreal Cognitive Assessment (MoCA) as Screening tool for cognitive impairment in mtbi. Suresh Kumar, M.D. AUTHOR Director of: Neurology & Headaches Center Inc. Neurocognitve &TBI Rehabilitation Center

More information

MR imaging of primary sclerosing cholangitis (PSC) using the hepatobiliary specific contrast agent Gd-EOB-DTPA

MR imaging of primary sclerosing cholangitis (PSC) using the hepatobiliary specific contrast agent Gd-EOB-DTPA MR imaging of primary sclerosing cholangitis (PSC) using the hepatobiliary specific contrast agent Gd-EOB-DTPA Poster No.: C-0019 Congress: ECR 2010 Type: Educational Exhibit Topic: Abdominal Viscera (Solid

More information

MPI Literature Review - Marijuana s effects on the adolescent brain

MPI Literature Review - Marijuana s effects on the adolescent brain General Summary: - Marijuana use appears to have a significant effect on adolescents brain structure and development. In particular, heavy marijuana use is associated with attention, memory, and planning

More information

Version History. Previous Versions. Drugs for MS.Drug facts box fingolimod Version 1.0 Author

Version History. Previous Versions. Drugs for MS.Drug facts box fingolimod Version 1.0 Author Version History Policy Title Drugs for MS.Drug facts box fingolimod Version 1.0 Author West Midlands Commissioning Support Unit Publication Date Jan 2013 Review Date Supersedes/New (Further fields as required

More information

Stage A & C Sample Data Collection Form

Stage A & C Sample Data Collection Form Stage A & C Sample Data Collection Form Instructions: Review a minimum of 20 patient charts (or another number determined to be appropriate) from patients most recently admitted, and complete this Data

More information

Cycling accidents registered at a department of radiology in 2010

Cycling accidents registered at a department of radiology in 2010 Cycling accidents registered at a department of radiology in 2010 Poster No.: C-0880 Congress: ECR 2013 Type: Authors: Scientific Exhibit J.-H. Opsahl 1, F. Wexels 2, T. E. Gudmundsen 1 ; 1 Drammen/NO,

More information

Chapter 10. Summary & Future perspectives

Chapter 10. Summary & Future perspectives Summary & Future perspectives 123 Multiple sclerosis is a chronic disorder of the central nervous system, characterized by inflammation and axonal degeneration. All current therapies modulate the peripheral

More information

Relapsing-remitting multiple sclerosis Ambulatory with or without aid

Relapsing-remitting multiple sclerosis Ambulatory with or without aid AVONEX/BETASERON/COPAXONE/EXTAVIA/GILENYA/REBIF/TYSABRI Applicant must be covered on an Alberta Government sponsored drug program. Page 1 of 5 PATIENT INFMATION Surname First Name Middle Initial Sex Date

More information

Diagnostic performance of MRI in differentiating metastatic from acute osteoporotic compression fractures of the spine

Diagnostic performance of MRI in differentiating metastatic from acute osteoporotic compression fractures of the spine Diagnostic performance of MRI in differentiating metastatic from acute osteoporotic compression fractures of the spine Poster No.: C-1399 Congress: ECR 2013 Type: Scientific Exhibit Authors: J. Martel,

More information

MULTIPLE SCLEROSIS AND DEPRESSION. Michael Racke, MD The Ohio State University Meera Narasimhan, MD University of South Carolina

MULTIPLE SCLEROSIS AND DEPRESSION. Michael Racke, MD The Ohio State University Meera Narasimhan, MD University of South Carolina MULTIPLE SCLEROSIS AND DEPRESSION Michael Racke, MD The Ohio State University Meera Narasimhan, MD University of South Carolina MICHAEL RACKE, MD Disclosures!! Research/Grants: National Institute of Neurologic

More information

Version History. Previous Versions. Policy Title. Drugs for MS.Drug facts box Glatiramer Acetate Version 1.0 Author

Version History. Previous Versions. Policy Title. Drugs for MS.Drug facts box Glatiramer Acetate Version 1.0 Author Version History Policy Title Drugs for MS.Drug facts box Glatiramer Acetate Version 1.0 Author West Midlands Commissioning Support Unit Publication Date Jan 2013 Review Date Supersedes/New (Further fields

More information

Cognitive Neuroscience. Questions. Multiple Methods. Electrophysiology. Multiple Methods. Approaches to Thinking about the Mind

Cognitive Neuroscience. Questions. Multiple Methods. Electrophysiology. Multiple Methods. Approaches to Thinking about the Mind Cognitive Neuroscience Approaches to Thinking about the Mind Cognitive Neuroscience Evolutionary Approach Sept 20-22, 2004 Interdisciplinary approach Rapidly changing How does the brain enable cognition?

More information

Optimization of treatment with interferon beta in multiple sclerosis. Usefulness of automatic system application criteria

Optimization of treatment with interferon beta in multiple sclerosis. Usefulness of automatic system application criteria Optimization of treatment with interferon beta in multiple sclerosis. Usefulness of automatic system application criteria AUTHORS Juan Luis Ruiz-Peña, Pablo Duque, and Guillermo Izquierdo Address: Unidad

More information

Summary chapter 2 chapter 2

Summary chapter 2 chapter 2 Summary Multiple Sclerosis (MS) is a chronic disease of the brain and the spinal cord. The cause of MS is unknown. MS usually starts in young adulthood. In the course of the disease progression of neurological

More information

in Persons with Multiple Sclerosis]

in Persons with Multiple Sclerosis] Faculty BARBARA S. GIESSER, MD Professor of Neurology Vice Chair, Education and Clinical Affairs, Neurology David Geffen School of Medicine University of California, Los Angeles Instructor Bio Barbara

More information

ß-interferon and. ABN Guidelines for 2007 Treatment of Multiple Sclerosis with. Glatiramer Acetate

ß-interferon and. ABN Guidelines for 2007 Treatment of Multiple Sclerosis with. Glatiramer Acetate ABN Guidelines for 2007 Treatment of Multiple Sclerosis with ß-interferon and Glatiramer Acetate Published by the Association of British Neurologists Ormond House, 27 Boswell Street, London WC1N 3JZ Contents

More information

Clinical Study Treatment of Fatigue in Multiple Sclerosis Patients: A Neurocognitive Approach

Clinical Study Treatment of Fatigue in Multiple Sclerosis Patients: A Neurocognitive Approach Rehabilitation Research and Practice Volume 2011, Article ID 670537, 5 pages doi:10.1155/2011/670537 Clinical Study Treatment of Fatigue in Multiple Sclerosis Patients: A Neurocognitive Approach Mauro

More information

The importance of early intervention clinician perspective. Øivind Grytten Torkildsen

The importance of early intervention clinician perspective. Øivind Grytten Torkildsen The importance of early intervention clinician perspective Øivind Grytten Torkildsen «You can never diagnose MS too late» Neuroradiologist from Norway, early 1990s Prognosis in untreated MS Early diagnosis

More information

Calendar of events NEUROLOGY

Calendar of events NEUROLOGY Calendar of events 2016 NEUROLOGY Rome, Italy 29 January 2016 Updates on MS treatment management Project an individualized treatment plan in MS Explain how to manage patients day to day issues List the

More information

STROKE CARE NOW NETWORK CONFERENCE MAY 22, 2014

STROKE CARE NOW NETWORK CONFERENCE MAY 22, 2014 STROKE CARE NOW NETWORK CONFERENCE MAY 22, 2014 Rehabilitation Innovations in Post- Stroke Recovery Madhav Bhat, MD Fort Wayne Neurological Center DISCLOSURE Paid speaker for TEVA Neuroscience Program.

More information

Thalamo-striato-cortical determinants to fatigue in multiple sclerosis

Thalamo-striato-cortical determinants to fatigue in multiple sclerosis Thalamo-striato-cortical determinants to fatigue in multiple sclerosis Maria Engström, Gullvi Flensner, Anne-Marie Landtblom, Anna-Christina Ek and Thomas Karlsson Linköping University Post Print N.B.:

More information

Memory Development and Frontal Lobe Insult

Memory Development and Frontal Lobe Insult University Press Scholarship Online You are looking at 1-10 of 11 items for: keywords : traumatic brain injury Memory Development and Frontal Lobe Insult Gerri Hanten and Harvey S. Levin in Origins and

More information

Plasticity after stroke: implications for motor and non-motor functions. Annapoorna Kuppuswamy Institute of Neurology Queen Square

Plasticity after stroke: implications for motor and non-motor functions. Annapoorna Kuppuswamy Institute of Neurology Queen Square Plasticity after stroke: implications for motor and non-motor functions Annapoorna Kuppuswamy Institute of Neurology Queen Square Talk structure Plasticity What is plasticity? Importance of plasticity

More information

2014 Neurologic Physical Therapy Professional Education Consortium Webinar Course Descriptions and Objectives

2014 Neurologic Physical Therapy Professional Education Consortium Webinar Course Descriptions and Objectives Descriptions and Neuroplasticity Health care providers are facing greater time restrictions to render services to the individual with neurological dysfunction. However, the scientific community has recognized

More information

Brain plasticity post stroke

Brain plasticity post stroke Brain plasticity post stroke NICK WARD NATIONAL HOSPITAL FOR NEUROLOGY AND NEUROSURGERY UCL INSTITUTE OF NEUROLOGY BASP: Advanced Stroke Medicine, 24 th March 2012 after thrombolysis... stroke damage Brain

More information

NEURO M203 & BIOMED M263 WINTER 2014

NEURO M203 & BIOMED M263 WINTER 2014 NEURO M203 & BIOMED M263 WINTER 2014 MRI Lab 1: Structural and Functional Anatomy During today s lab, you will work with and view the structural and functional imaging data collected from the scanning

More information

Reversibility of Acute Demyelinating Lesions in relapsingremitting

Reversibility of Acute Demyelinating Lesions in relapsingremitting Reversibility of Acute Demyelinating Lesions in relapsingremitting Multiple Sclerosis Omar A. Khan ( Division of Neuroimmunology, Department of Neurology, Neurology and Research Services. Veterans Affairs

More information

College of Health and Human Services Department of Physical Therapy

College of Health and Human Services Department of Physical Therapy College of Health and Human Services Department of Physical Therapy Neurological Evaluation & Treatment II (PT244) Fall Semester 2009 COURSE CREDIT: 4 units: 2 hours lecture, 6 hours of lab per week CLASSROOM:

More information

Pneumocystis Jiroveci: Imaging Findings on HRCT

Pneumocystis Jiroveci: Imaging Findings on HRCT Pneumocystis Jiroveci: Imaging Findings on HRCT Poster No.: C-2491 Congress: ECR 2015 Type: Educational Exhibit Authors: R. E. Correa Soto, J. M. Fernandez Garcia-Hierro, M. J. Martín 1 1 2 1 1 Sánchez,

More information

Revised (2009) Association of British Neurologists guidelines for prescribing in multiple sclerosis

Revised (2009) Association of British Neurologists guidelines for prescribing in multiple sclerosis Revised (2009) guidelines for prescribing in multiple sclerosis INTRODUCTION In January 2001, the (ABN) first published guidelines for the use of licensed disease modifying treatments (ß-interferon and

More information

Tic Tock: Trends in Tics and Tourette Syndrome

Tic Tock: Trends in Tics and Tourette Syndrome Tic Tock: Trends in Tics and Tourette Syndrome Audrey Foster- Barber, MD, PhD Child Neurology University of California, San Francisco Advances and Controversies in Pediatrics June 2, 2007 Overview Review

More information

Mellen Center for Multiple Sclerosis

Mellen Center for Multiple Sclerosis Mellen Center Cleveland Clinic Marie Namey, RN, MSN, MSCN Mellen Center Cleveland Clinic Cleveland, OH Home of. Mellen Center for Multiple Sclerosis Mellen Center Mission The Mellen Center remains committed

More information

Abdominal CT Perfusion: Effects of Breath Control Technique

Abdominal CT Perfusion: Effects of Breath Control Technique Abdominal CT Perfusion: Effects of Breath Control Technique Poster No.: C-0068 Congress: ECR 2014 Type: Scientific Exhibit Authors: T. Yoshikawa, T. Kanda, Y. Ohno, Y. Fujisawa, N. Negi, M. 1 1 2 1 1 1

More information

Supplementary appendix

Supplementary appendix Supplementary appendix This appendix formed part of the original submission and has been peer reviewed. We post it as supplied by the authors. Supplement to: Gold R, Giovannoni G, Selmaj K, et al, for

More information

Summary HTA. Interferons and Natalizumab for Multiple Sclerosis Clar C, Velasco-Garrido M, Gericke C. HTA-Report Summary

Summary HTA. Interferons and Natalizumab for Multiple Sclerosis Clar C, Velasco-Garrido M, Gericke C. HTA-Report Summary Summary HTA HTA-Report Summary Interferons and Natalizumab for Multiple Sclerosis Clar C, Velasco-Garrido M, Gericke C Health policy background Multiple sclerosis (MS) is a chronic inflammatory disease

More information

Index. Page numbers followed by f indicate figures; page numbers followed by t indicate tables.

Index. Page numbers followed by f indicate figures; page numbers followed by t indicate tables. Index Page numbers followed by f indicate figures; page numbers followed by t indicate tables. Acetylcholine, 95, 97, 114 ACTH (adrenocorticotropine hormone), 63, 146, 147, 285 Amantadine, 66, 99, 100,

More information

1695 N.W. 9th Avenue, Suite 3302H Miami, FL. 33136. Days and Hours: Monday Friday 8:30a.m. 6:00p.m. (305) 355 9028 (JMH, Downtown)

1695 N.W. 9th Avenue, Suite 3302H Miami, FL. 33136. Days and Hours: Monday Friday 8:30a.m. 6:00p.m. (305) 355 9028 (JMH, Downtown) UNIVERSITY OF MIAMI, LEONARD M. MILLER SCHOOL OF MEDICINE CLINICAL NEUROPSYCHOLOGY UHEALTH PSYCHIATRY AT MENTAL HEALTH HOSPITAL CENTER 1695 N.W. 9th Avenue, Suite 3302H Miami, FL. 33136 Days and Hours:

More information

Prior Authorization, Pharmacy and Health Case Management Information. Prior Authorization. Pharmacy Information. Health Case Management

Prior Authorization, Pharmacy and Health Case Management Information. Prior Authorization. Pharmacy Information. Health Case Management Prior Authorization, Pharmacy and Health Case Management Information The purpose of this information sheet is to provide you with details on how Great-West Life will be assessing and managing your claim

More information

Measurement Issues in Short Term Clinical Trials. Brian Healy, PhD

Measurement Issues in Short Term Clinical Trials. Brian Healy, PhD Measurement Issues in Short Term Clinical Trials Brian Healy, PhD Overview n In order to iden>fy treatment effects or predictors of disease course, measurement of disease course is required n Although

More information

Supplementary Online Content

Supplementary Online Content Supplementary Online Content Burt RK, Balabanov R, Han X, et al. Association of nonmyeloablative hematopoietic stem cell transplantation with neurological disability in patients with relapsing-remitting

More information

Chronic kidney disease and cerebral small vessel disease

Chronic kidney disease and cerebral small vessel disease Chronic kidney disease and cerebral small vessel disease M. Arfan Ikram, MD PhD Department of Epidemiology, Radiology, Neurology Erasmus MC Rotterdam, The Netherlands No disclosures Kidney-brain: Two pulsating

More information

PCORI Workshop on Treatment for Multiple Sclerosis. Breakout Group Topics and Questions Draft 3-27-15

PCORI Workshop on Treatment for Multiple Sclerosis. Breakout Group Topics and Questions Draft 3-27-15 PCORI Workshop on Treatment for Multiple Sclerosis Breakout Group Topics and Questions Draft 3-27-15 Group 1 - Comparison across DMTs, including differential effects in subgroups Consolidated straw man

More information

FUNCTIONAL EEG ANALYZE IN AUTISM. Dr. Plamen Dimitrov

FUNCTIONAL EEG ANALYZE IN AUTISM. Dr. Plamen Dimitrov FUNCTIONAL EEG ANALYZE IN AUTISM Dr. Plamen Dimitrov Preamble Autism or Autistic Spectrum Disorders (ASD) is a mental developmental disorder, manifested in the early childhood and is characterized by qualitative

More information

Clinical Commissioning Policy: Disease Modifying Therapies For patients With Multiple Sclerosis (MS) December 2012. Reference : NHSCB/D4/c/1

Clinical Commissioning Policy: Disease Modifying Therapies For patients With Multiple Sclerosis (MS) December 2012. Reference : NHSCB/D4/c/1 Clinical Commissioning Policy: Disease Modifying Therapies For patients With Multiple Sclerosis (MS) December 2012 Reference : NHSCB/D4/c/1 NHS Commissioning Board Clinical Commissioning Policy: Disease

More information

Rational basis for early treatment in MS. Bonaventura Casanova Estruch Unitat d Esclerosi Múltiple Hospital Universitari la Fe València

Rational basis for early treatment in MS. Bonaventura Casanova Estruch Unitat d Esclerosi Múltiple Hospital Universitari la Fe València Rational basis for early treatment in MS Bonaventura Casanova Estruch Unitat d Esclerosi Múltiple Hospital Universitari la Fe València Bonaventura Casanova Department of Neurology University Hospital La

More information

Prior Authorization, Pharmacy and Health Case Management Information. Prior Authorization. Pharmacy Information. Health Case Management

Prior Authorization, Pharmacy and Health Case Management Information. Prior Authorization. Pharmacy Information. Health Case Management Prior Authorization, Pharmacy and Health Case Management Information The purpose of this information sheet is to provide you with details on how Great-West Life will be assessing and managing your claim

More information

Cognitive Rehabilitation of Blast Traumatic Brain Injury

Cognitive Rehabilitation of Blast Traumatic Brain Injury Cognitive Rehabilitation of Blast Traumatic Brain Injury Yelena Bogdanova, PhD VA Boston Healthcare System Rehabilitation Research & Development Boston University School of Medicine IOM Committee on Cognitive

More information

MRI in Differential Diagnosis

MRI in Differential Diagnosis MRI in Differential Diagnosis Jill Conway, MD, MA, MSCE Director, Carolinas MS Center Clerkship Director, UNCSOM-Charlotte Campus Charlotte, NC DISCLOSURES Speaking, consulting, and/or advisory boards

More information

Whole-brain Functional MR Imaging Activation from a Finger-tapping Task Examined with Independent Component Analysis

Whole-brain Functional MR Imaging Activation from a Finger-tapping Task Examined with Independent Component Analysis AJNR Am J Neuroradiol 21:1629 1635, October 2000 Whole-brain Functional MR Imaging Activation from a Finger-tapping Task Examined with Independent Component Analysis Chad H. Moritz, Victor M. Haughton,

More information

Anoxic Brain Injury and Neural Damage: Three Case Reports

Anoxic Brain Injury and Neural Damage: Three Case Reports Anoxic Brain Injury and Neural Damage: Three Case Reports Abstract Anoxic brain injury (ABI) is common and can occur in a wide variety of disorders. This neural injury is associated with significant and

More information

Imaging Markers of Brain Network Dysfunction in Multiple Sclerosis

Imaging Markers of Brain Network Dysfunction in Multiple Sclerosis Faculty of Medicine & Health Sciences School of Medicine Radiological Sciences Research Group The University of Nottinham University Park Nottingham NG7 2RD t: +44 (0)115 823 0018 f: +44 (0)115 823 0004

More information

The Use of the Lokomat System in Clinical Research

The Use of the Lokomat System in Clinical Research International Neurorehabilitation Symposium February 12, 2009 The Use of the Lokomat System in Clinical Research Keith Tansey, MD, PhD Director, Spinal Cord Injury Research Crawford Research Institute,

More information

Exercise therapy and multiple sclerosis a powerful non-pharmacological intervention

Exercise therapy and multiple sclerosis a powerful non-pharmacological intervention Malmö, November 2014 Exercise therapy and multiple sclerosis a powerful non-pharmacological intervention Ulrik Dalgas, PhD Department of Public Health Section of Sport Science Aarhus University Denmark

More information

Disease Modifying Therapies (DMTs) in Multiple Sclerosis

Disease Modifying Therapies (DMTs) in Multiple Sclerosis Disease Modifying Therapies (DMTs) in Multiple Sclerosis Gary Stobbe, MD Medical Director, MS Project ECHO Clinical Assistant Professor, UW Neurology Conflict of Interest Dr. Stobbe has no conflicts of

More information

Supplementary webappendix

Supplementary webappendix Supplementary webappendix This webappendix formed part of the original submission and has been peer reviewed. We post it as supplied by the authors. Supplement to: Giovannoni G, Gold R, Selmaj K, et al,

More information

PRO BALLOON VENOPLASTY IS A PROMISING TECHNOLOGY FOR TREATMENT OF MS

PRO BALLOON VENOPLASTY IS A PROMISING TECHNOLOGY FOR TREATMENT OF MS PRO BALLOON VENOPLASTY IS A PROMISING TECHNOLOGY FOR TREATMENT OF MS Manish Mehta MD MPH The Vascular Group The Institute for Vascular Health & Disease Albany Medical Center SVS 2012 DISCLOSURES Research,

More information

Magnetic Resonance Techniques in Multiple Sclerosis

Magnetic Resonance Techniques in Multiple Sclerosis Università Vita-Salute San Raffaele Neuroimaging Research Unit Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute and Vita - Salute San Raffaele University

More information

By Dr. Mindy Aisen CEO and Director United Cerebral Palsy Research and Educational Foundation www.ucpresearch.org CEREBRAL PALSY RESEARCH

By Dr. Mindy Aisen CEO and Director United Cerebral Palsy Research and Educational Foundation www.ucpresearch.org CEREBRAL PALSY RESEARCH By Dr. Mindy Aisen CEO and Director United Cerebral Palsy Research and Educational Foundation www.ucpresearch.org CEREBRAL PALSY RESEARCH Main Sources of Federal Funding for Cerebral Palsy and Disability

More information

Effect of BEMER Magnetic Field Therapy on the Level of Fatigue in Patients with Multiple Sclerosis: A Randomized, Double-Blind Controlled Trial

Effect of BEMER Magnetic Field Therapy on the Level of Fatigue in Patients with Multiple Sclerosis: A Randomized, Double-Blind Controlled Trial THE JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE Volume 15, Number 5, 2009, pp. 507 511 ª Mary Ann Liebert, Inc. DOI: 10.1089=acm.2008.0501 Effect of BEMER Magnetic Field Therapy on the Level of Fatigue

More information

Progress in MS: Current and Emerging Therapies

Progress in MS: Current and Emerging Therapies Progress in MS: Current and Emerging Therapies Presented by: Dr. Kathryn Giles, MD MSc FRCPC The MS Society gratefully acknowledges the grant received from Biogen Idec Canada, which makes possible the

More information