OA related pain medication intake in subjects from the OAI incidence cohort - association with focal knee lesions and cartilage T2 measurements

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1 OA related pain medication intake in subjects from the OAI incidence cohort - association with focal knee lesions and cartilage T2 measurements Poster No.: C-0007 Congress: ECR 2012 Type: Scientific Exhibit Authors: T. Baum, C. Stehling, G. Joseph, L. NARDO, W. Virayavanich, H. Alizai, A. Arulanandan, C. McCulloch, T. M. Link; San Francisco, CA/US Keywords: DOI: MR, Musculoskeletal joint, Segmentation, Imaging sequences, Tissue characterisation /ecr2012/C-0007 Any information contained in this pdf file is automatically generated from digital material submitted to EPOS by third parties in the form of scientific presentations. References to any names, marks, products, or services of third parties or hypertext links to thirdparty sites or information are provided solely as a convenience to you and do not in any way constitute or imply ECR's endorsement, sponsorship or recommendation of the third party, information, product or service. ECR is not responsible for the content of these pages and does not make any representations regarding the content or accuracy of material in this file. As per copyright regulations, any unauthorised use of the material or parts thereof as well as commercial reproduction or multiple distribution by any traditional or electronically based reproduction/publication method ist strictly prohibited. You agree to defend, indemnify, and hold ECR harmless from and against any and all claims, damages, costs, and expenses, including attorneys' fees, arising from or related to your use of these pages. Please note: Links to movies, ppt slideshows and any other multimedia files are not available in the pdf version of presentations. Page 1 of 8

2 Purpose To evaluate the association of baseline knee cartilage T2 relaxation time values and focal knee lesions in subjects from the Osteoarthritis Initiative (OAI) incidence cohort with future osteoarthritis (OA) related pain medication intake. Methods and Materials 140 subjects (64 males, 76 females) with risk factors for knee OA (such as history of knee injury, history of knee surgery, or family history of knee replacement), years of age, BMI of kg/m² and without knee pain in either knee (WOMAC pain score of zero) at baseline were included in this study. They were selected from the Osteoarthritis Initiative (OAI) incidence cohort. Baseline bilateral standing posterior-anterior fixed flexion knee radiographs were acquired. Right knee radiographs were graded by two radiologists in consensus by using the Kellgren-Lawrence (KL) scoring system Baseline 3T MR images of the right knee were assessed for presence and grade of abnormalities using the whole organ MRI score (WORMS) by two radiologists. Cartilage segmentation and T2 measurements were performed in five compartments: patella, medial/lateral femur/tibia (Figure 1, 2, 3). Knee pain associated medication intake was monitored with a standardized questionnaire over a period of one year after baseline MRI. Multivariate linear and logistic regression models were used to determine significant differences between subjects with versus without pain medication intake, adjusting for gender, age, OA risk factors, and KL-score. Images for this section: Page 2 of 8

3 Fig. 0: Cartilage segmentation in the T2 maps of the patella, lateral femur, and lateral tibia. Page 3 of 8

4 Fig. 0: Cartilage segmentation in the T2 maps of the medial femur and medial tibia. Page 4 of 8

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6 Fig. 0: Color-coded T2 maps of the segmented cartilage compartmens of patella, lateral femur, and lateral tibia (A) and medial femur and medial tibia (B). Page 6 of 8

7 Results Pain medication intake for OA over a period of one year was reported for 39 of the 140 subjects (28%). The severity, but not the prevalence of cartilage lesions at baseline was significantly higher in subjects with pain medication intake (p<0.05). Subjects with pain medication intake also showed significantly higher T2 values in all compartments (p<0.05; 44.14ms versus 45.65ms averaged over all compartments). Conclusion More severe cartilage lesions and higher T2 values at baseline are associated with future OA related pain medication intake in middle-aged subjects from the OAI incidence cohort. Knee cartilage T2 relaxation time values and severity of focal cartilage lesions might be indicators for future osteoarthritis related pain and consequential pain medication intake. References The OAI is a public-private partnership comprised of five contracts (N01-AR ; N01- AR ; N01-AR ; N01-AR ; N01-AR ) funded by the National Institutes of Health, a branch of the Department of Health and Human Services, and conducted by the OAI Study Investigators. Private funding partners include Merck Research Laboratories; Novartis Pharmaceuticals Corporation, GlaxoSmithKline; and Pfizer, Inc. Private sector funding for the OAI is managed by the Foundation for the National Institutes of Health. This study was supported by NIH U01AR (T.M.L.) and NIH F32AR (G.J.). Personal Information Thomas Baum; Musculoskeletal and Quantitative Imaging Research Group; Page 7 of 8

8 Department of Radiology and Biomedical Imaging; University of California San Francisco; 185 Berry Street, Suite 350; San Francisco, CA 94107, USA; Page 8 of 8