Pericentric Inversions (around the centromere)
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1 Pericentric Inversions (around the centromere) Kinds of chromatids produced by various crossovers within the inversion in a pericentric inversion heterozygote C.O. event Position of C.O. Constitution i of 4 chromatids after C.O. CO Normal Inversion dp + df Single C.O Any point Double 2-Strand 12 1, Strand 1,3 or 1, Strand 15 1, The numbers in column 2 refer to those in inversion figure. C.O.=Crossover
2 Pericentric Inversions (around dthe centromere) The two types of inversions (para- and peri-centric) result in different cytological events Chromosome inversions have no effect on mitotic divisions, but do effect meiosis Meiosis is normal in individuals with homozygous inversions If the inverted regions of the inversion heterozygote is large enough for crossing-over to occur within ihi the inversion i loop, a portion of the resulting li gametes will be abnormal
3 Pericentric Inversions (around the centromere) Pericentric inversions result in dp + df gametes which is related to the chromosome segments distal to the breakpoints of the inverted segment Products of crossover event within the loop are lost 1. Recombinant types are not recovered 2. Crossing over may not be suppressed cytologically 3. Only 2 strand double crossover types are recovered No bridges or fragments produced at anaphase I or II
4 Paracentric Inversions (beside the centromere) In plants pa A homozygous inversion will produce normal pollen and seed set A heterozygous inversion will produce partial ovule and pollen abortion The degree of pollen abortion is dependent d upon the amount of crossing-over within the inversion loop To distinguish a homozygous inversion from a homozygous normal individual, the unknown can be crossed with a homozygous normal individual If the unknown is a homozygous inversion, the F 1 will be ht heterozygous for the inversion i and dbe partially till sterile
5 Paracentric Inversions (beside the centromere) Crossing-over in paracentric inversions result in bridges (dicentric chromosomes) and dfragments (acentric chromosomes) The size of the acentric fragment represents the length of the inverted region plus twice the length of the distal segment If deficiencies for the segment distal to the inversion, resulting from the loss of the acentric fragment, cause gamete spore abortion, the pollen abortion percentage can be predicted by cytological observation of meiosis
6 Paracentric Inversions (besides the centromere) Kinds of chromatids produced by various crossovers in a paracentric inversion heterozygote C.O. event Position of C.O. Constitution of 4 chromatids after C.O. Normal Inversion dp + df Single C.O Any point (dicentric+acentric) Double 2-Strand 1, Strand 1,3 or 1, (dicentric+acentric) 4-Strand 1, (dicentric+acentric) IN/OUT 1 in loop + 1 in interstitial (dicentric+acentric) IN/OUT 4-strand double (dicentric+acentric) 1 in interstitial
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8 Chromatid tie in Dorsophila female Oogenesis Division vso I Division vso II A dicentric bridge orients crossover chromatids away from the poles at division I Deficiency-duplication chromatids will occur in intercalary cell and polar cells will produce a fertile ovum with intact chromosomes
9 During female gamete formation in plants and animals, only one polar megaspore will function in production of the ovule The duplication-deficiency chromosomes are oriented to the intercalary cells by the chromatid tie and the normal chromosomes will be included in the nuclei of the polar cells more often than the dp-df chromosomes The result will be nearly normal female fertility of inversion heterozygotes, but recombination will be substantially reduced in regions involved din the inversion i
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11 Use of inversions to produce duplications without deficiencies Intercross two inversions with one breakpoint in common: X
12 Intercross overlapping inversions: X
13 c b d a e A double crossover is required for recovery of chromatid with recombination within the inversion loop c will have greatest amount of recombination with a b and d will have equal amount of recombination with a, but less than c c a b d e
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15 Interchromosomal Translocation (part of one chromosome is attached to another) Types 1. Interstitial translocations (intercalary) A segment from one chromosome is transferred to a position in another chromosome. Requires three breaks. 2. Reciprocal translocation (interchange) Two non-homologous chromosomes have symmetrically exchanged segments. One break in each chromosome is sufficient. Nearly always involves terminal end segments. I t titi l t t f i t h h b t th b k i t Interstitial segment = segment of an interchange chromosome between the breakpoint and the centromere.
16 Interchromosomal Translocation A cross configuration is formed at pachytene of interchange heterozygotes. The position of the cross is a reflection of where the breakpoint has occurred. During diplotene and diakinesis, the chromosomes shorten, the chiasma terminalize, and the cross configuration opens up to form a ring of 4 if chiasma are present.
17 a b 1 c d e f 2 g h a b 1 2 g h e f 2 1 c d Pachytene pairing of interchange heterozygote d d a b 1 c c 2 1 e f a b e f g h g h
18 1 c d d c 2 1 e b f a f a e b 1 2 g h h g 2
19 Interchromosomal Translocation Observed meiotic configurations depend on the occurrence of chiasmata No. of Arms with Chiasma Diakinesis Configuration 4 Ring of 4 (4) 3 Chain of 4 (IV, 4 types) 2 adjacent arms Chain of 3 + univalent (III+I, 4 types) 2 alternate arms 2 pairs (2II, 2 types)
20 Orientation of interchange heterozygote quadrivalent at Metaphase I Adjacent I a b 1 c d c d 2 1 e f a b e f g h g h Adjacent non-homologous centromeres pass to the same pole dp cd + df gh dp gh + df cd
21 Orientation of interchange heterozygote quadrivalent at Metaphase I Adjacent II a b a b 1 2g h 1 c d g h c d 2 e f 2 1 e f Adjacent homologous centromeres pass to the same pole dp ab + df ef dp ef + df ab
22 Orientation of interchange heterozygote quadrivalent at Metaphase I Alternate a b 1 c d c d 2 1 e f a b e f g h g h Alternate disjunction of nonhomologous centromeres Normal Balanced translocation
23 Disjunction from a ring quadrivalent Orientation of chromosomes of a ring of 4 may be either an open or a zig-zag zag configuration leading to either adjacent or alternate chromosome disjunction. Adjacent I disjunction Adjacent but non-homologous centromeres migrate to the same pole Dp fe +Df jk Dp=duplication p Dp jk +Df fe Df=deficiency Gametes usually abort. Adjacent II disjunction Occurs rarely if ever. Adjacent but homologous o ogous centromeres e es migrate to the same pole Dp abcd +Df ghi Dp ghi+df abcd Gametes abort.
24 Disjunction from a ring quadrivalent Alternate disjunction Alternate centromeres migrate to the same pole at anaphase I Normal chromosome complement Interchange chromosome complement Both combinations produce viable gametes.
25 Factors influencing orientation of a ring quadrivalent Considering 2 normal bivalents, there is complete independence and adjacent I and alternate disjunction will occur with equal frequency. Adjacent II should be impossible since there is no opportunity for coorientation between non-homologous centromeres. With production of quadrivalent co-orientation orientation of non-homologous centromeres becomes possible. With random co-orientation: alternate disjunction i frequency = adjacent disjunction i frequency Even within species there is considerable genetic variation affecting the ratio of alternate and adjacent disjunction. In most cases either alternate or adjacent predominates so that co-orientation is not a reality. Random orientation may occur in early prophase but soon forces act on quadrivalent, changing the orientation of the quadrivalent.
26 Factors influencing orientation of a ring quadrivalent Forces acting on the quadrivalent: 1. Contraction of chromosomes resulting in stiffness and torsion. Short stiff chromosomes or those with little tendency for chiasma terminalization do not have sufficient flexibility for alternate disjunction. 2. Centromere activity Centromere orientation is maintained by the presence of counter-force exerted on the centromere Alternate orientation provided more stable counter forces and will not readily revert to adjacent orientation. With adjacent orientation if the pull from a single opposite centromere lapses, both co-orienting centromeres become unstable and resume equal probabilities to orient to either pole. With time the alternate orientation often accumulates. In rye interchange heterozygotes, alternate rings may occur in up to 95% of PMCs in late metaphase.
27 Factors influencing orientation of a ring quadrivalent 1. Forces acting on the quadrivalent. 2. Length of interchange and interstitial segment. 3. Localization and terminalization of chiasmata. Genetic consequence of interchange An interchange behaves like a single genetic factor. Two reciprocal translocations that do not have a chromosome in common segregate independently. In the translocation homozygote, the linkage relationship will be changed. Genes in the translocated segment fail to show linkage with genes in the chromosome where they originally i occurred.
28 Products of Alternate disjunction a b 1 c d e f 2 g h a b 1 2 g h e f 2 1 c d Normal linkage map Linkage map from progeny of translocation heterozygote A B C D E F G H A B E F C D G H
29 Identification i of chromosomes involved in interchanges 1. Cytology Pachytene analysis of chromosomes involved in the cross configuration Karyotype analysis of somatic cells Unequal size of exchange segment allows identification of change in chromosome lengths Banding pattern of chromosomes Direct observation of Dorsophila salivary gland chromosome bands 2. Genetic Linkage Genes on one chromosome become linked to those on another Genes known to be linked or independent suddenly change relationship
30 Identification of chromosomes involved in interchanges 1. Use of trisomic tester 2n+1 known trisomic tester lines are crossed with unknown interchange stocks If one of the chromosomes involved in the translocation is the trisomic chromosome, a chain of 5 is expected If the trisomic i does not involve one of the interchange chromosomes, a ring of 4 plus a trivalent are expected 2. Chromosome identification set Cross a series of known interchange stocks with the unknown interchange stock and examine the F1 at meiotic metaphase I Two rings of 4 indicate the interchanges are independent A ring of 6 indicates one chromosome of the interchange is in common with one of the tester interchange chromosomes An F1 from a cross between interchange stocks involving the same two chromosomes will not produce an association larger than a ring of 4 or may produce mostly/only pairs
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