INDEX. Performance Improvement Program in Surgical Pathology SURVEYS 2012 AND ANATOMIC PATHOLOGY EDUCATION PROGRAMS

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1 INDEX SURVEYS 2012 AND ANATOMIC PATHOLOGY EDUCATION PROGRAMS Performance Improvement Program in Surgical Pathology

2 PIP CASE SUMMARY INDEX Breast Angiosarcoma 86% Tubular adenoma 97% Medullary carcinoma 97% Phyllodes tumor 95% Infiltrating lobular carcinoma 87% Adenoid cystic carcinoma 95% Lobular carcinoma in situ 86% Tubular adenoma 88% Infiltrating ductal carcinoma 88% Low grade cystosarcoma phyllodes 96% Silicone granuloma 94% Papillary carcinoma 83% Ductal hyperplasia without atypia 67% Well differentiated adenocarcinoma 60% Phyllodes tumor 66% Sarcoma 89% Metaplastic carcinoma 92% Lipid rich carcinoma 65% Infiltrating mammary carcinoma, NOS 24% Hyperplasia, lobular, atypical (Kodachrome) 56% Lactating adenoma 93% Ductal carcinoma in situ, comedo-type 91% Silicone reaction (silicone granuloma) 89% Infiltrating ductal carcinoma breast 59% Invasive lobular carcinoma of the breast, pleomorphic type 98% Cystosarcoma phyllodes with sclerosing liposarcoma 88% Lactating adenoma, breast 87% Ductal carcinoma in situ, low grade 80% Colloid carcinoma (mucinous carcinoma) 99% Adenomyoepithelioma 76% Infiltrating lobular carcinoma 88% Ductal carcinoma in situ 72% Infiltrating ductal carcinoma of no special type 84% Undifferentiated carcinoma 28% Invasive ductal carcinoma of no special type, grade III/III 94% Benign phyllodes tumor 79% Invasive micropapillary carcinoma 93% Myofibroblastoma 87% Phyllodes tumor 87% Metaplastic carcinoma 85% Metaplastic carcinoma 95% Sarcomatoid carcinoma (metaplastic carcinoma) 94% Malignant phyllodes tumor 99% Infiltrating duct carcinoma, poorly differentiated 96% Invasive lobular carcinoma 98% Pseudoangiomatous stromal hyperplasia 97% Phyllodes tumor, low grade 90%

3 Cardiovascular Giant cell myocarditis 94% Temporal arteritis (giant cell arteritis) 99% Granulomatous myocarditis 71% Acute cellular rejection, moderate 16% Eosinophilic myocarditis 97% Vasculitis, histologically compatible with polyarteritis nodosa 72% Cardiac myxoma 97% Severe acute cellular rejection and chronic vasculopathy 69% Cardiac hemosiderosis 48% Cardiac myxoma 98% Endocrine Parathyroid adenoma 94% Hashimoto thyroiditis 89% Follicular lesion (follicular neoplasm) of thyroid 73% Papillary thyroid carcinoma 71% Malignant pancreatic endocrine tumor (islet cell) 86% Adrenal cortical adenoma 62% Medullary carcinoma 94% Pheochromocytoma 90% Primary parathyroid hyperplasia 88% Paraganglioma 81% Nodular goiter 91% Adrenal cortical carcinoma 90% Papillary carcinoma 85% Follicular carcinoma, insular type 65% Parathyroid adenoma 96% Hashimoto thyroiditis 65% Brown tumor of hyperparathyroidism 85% Papillary carcinoma 99% Angioinvasive follicular carcinoma 37% Adrenal cortical carcinoma 83% Anaplastic carcinoma 78% Pheochromocytoma (composite variant) 96% Follicular thymic hyperplasia 90% Medullary carcinoma 84% Hürthle cell papillary adenoma 65% Adrenal pseudocyst 87% Myelolipoma 88% Parathyroid adenoma 92% Chronic lymphocytic thyroiditis - slide unavailable (data can not be calculated) Diffuse toxic goiter 70% Medullary thyroid carcinoma 94% Pheochromocytoma 95% Precursor T-cell acute lymphoblastic lymphoma 95% Myelolipoma 95% Hashimoto thyroiditis, fibrous variant 86% Paraganglioma 92% Graves Disease (diffuse toxic goiter) 88% Papillary carcinoma (NOS, usual type) 49% Pheochromocytoma 96% Solid-pseudopapillary tumor 78% Extranodal marginal zone B-cell (MALT) lymphoma 78% Hürthle cell carcinoma 65%

4 Endocrine Ganglioneuroma 96% Neuroblastoma, poorly differentiated 69% Undifferentiated (anaplastic) carcinoma 97% Adrenal cortical carcinoma 89% Myelolipoma 95% Papillary carcinoma, classical type 80% Undifferentiated (anaplastic) carcinoma 97% Follicular variant of papillary carcinoma 97% Autoimmune (Hashimoto) thyroiditis 99% Adrenal cortical carcinoma 87% Carcinoma with thymus-like elements 86% Pheochromocytoma 98% Medullary carcinoma 99% Acinar cell carcinoma 96% Neuroblastoma, poorly differentiated 89% Pancreatic neuroendocrine tumor 96% Solid-pseudopapillary neoplasm 97% Gastrointestinal Hyperplastic polyp 90% Cloacogenic carcinoma, basaloid type, of anal canal 99% Stromal tumor (cellular leiomyoma) of stomach 90% Crohn disease of ileum 98% Familial adenomatous polyposis coli 99% Villous adenoma 90% Carcinoid tumor of the appendix 92% Crohn disease of colon 86% Helicobacter pylori gastritis 66% Ulcerative colitis 64% Adenocarcinoma of stomach, diffuse type (linitis plastica) 98% Adenocarcinoma of colon, moderately to poorly differentiated grade II/III 77% Leiomyosarcoma of the stomach 75% Pseudomembranous colitis 99% Barrett's esophagus with dysplasia 89% Acute infectious colitis 86% Ulcerative colitis 95% Epithelioid leiomyoma of stomach 90% Ischemic colitis 94% Leiomyosarcoma of colon 94% Pneumatosis cystoides intestinales 95% Acute appendicitis 85% Barrett's esophagus 95% Mucinous adenocarcinoma of rectum 95% Microcystic adenoma 90% Diversion colitis 79% Crohn disease 83% Small cell carcinoma of the colon 82% Carcinoid tumor of small bowel 94% Malignant gastric stromal tumor 89% Collagenous colitis (kodachrome) 78% Adenocarcinoma, pancreas 53% Crohn disease 95% Solid-cystic papillary epithelial neoplasm, pancreas 61% Pancreatic endocrine tumor 76% Adenocarcinoma, cecum 62% Fibromatosis, small bowel 94% Acute self-limited colitis (infectious colitis) 54%

5 Gastrointestinal Malignant gastrointestinal stromal tumor N/A Cytomegalovirus colitis 66% Chronic active gastritis 80% Adenocarcinoma 93% Neutropenic enterocolitis (typhilitis) 73% Pneumatosis cystoides intestinalis 93% Inflammatory fibroid polyp 87% Microcystic adenoma 95% Pancreatoblastoma 91% Ischemic colitis 94% Hirschsprung's disease 90% Strongyloidiasis (autoinfection) 96% Peutz-Jeghers (hamartomatous) polyp 87% Familial polyposis 98% Crohn colitis 82% Adenocarcinoma 77% Ulcerative colitis 96% Acinar cell carcinoma 94% Cytomegalovirus esophagitis 82% Pancreatic endocrine tumor (gastrinoma) 90% Diffuse B-cell lymphoma (Gastric large cell lymphoma) 84% Eosinophilic gastroenteritis 99% Lymphocytic colitis 80% Basaloid squamous carcinoma 60% Clostridium difficile pseudomembranous colitis 98% Solid-pseudopapillary tumor 75% Gastrointestinal stromal tumor 91% Ductal adenocarcinoma 91% Inflammatory fibroid polyp 67% Malakoplakia 93% Invasive poorly differentiated adenocarcinoma with mucinous and signet ring cell features N/A Active chronic gastritis, Helicobacter pylori-associated (type B gastritis, chronic antral gastritis) 99% Pancreatic endocrine neoplasm (islet tumor) 84% Gastrointestinal stromal tumor, malignant 99% Active chronic colitis, severe, consistent with fulminant phase of chronic ulcerative colitis 57% Cytomegalovirus colitis 90% Serous microcystic adenoma 97% Adenocarcinoma, intestinal type 74% Adenocarcinoma, primary 82% Ischemic colitis 81% Teratoma 94% Adenocarcinoma of gallbladder 87% Signet-ring carcinoma 82% Burkitt lymphoma 83% Pseudomembranous colitis 98% Mixed carcinoid-adenocarcinoma 98% Bacillary angiomatosis 71% Adenocarcinoma 92% Melanoma 60% Metastatic renal cell carcinoma 99% Mucinous cystic neoplasm (mucinous cystadenoma) 95% Pancreatic endocrine carcinoma - 97% Adenocarcinoma of the small bowel, arising in celiac disease 74% Microcystic serous cystadenoma 97% Crohn disease 99% Mucinous carcinoma arising in an intraductal papillary mucinous neoplasm 92%

6 Gastrointestinal Gastrointestinal stromal tumor 99% Lymphoepithelial cyst 88% Plasmacytoma 99% Adenocarcinoma, diffuse (signet ring cell) type 96% Sclerosing mesenteritis 96% Acinar cell carcinoma 92% Solid pseudopapillary neoplasm 98% Ulcerative colitis 94% Pseudomembranous colitis secondary to Clostridium difficile infection 98% Pneumatosis (cystoides) intestinalis related to progressive systemic sclerosis 91% Crohn disease 96% Well-differentiated pancreatic endocrine tumor 90% Medullary carcinoma 80% Multicystic peritoneal mesothelioma 95% Clostridium difficile pseudomembranous colitis 98% Mucinous adenocarcinoma 86% Epithelioid trophoblastic tumor 88% Microcystic serous cystadenoma 98% Collagenous colitis 96% Gastrointestinal stromal tumor 97% Mesenteric fibromatosis 94% Sclerosing mesenteritis 94% Neuroendocrine tumor, WHO grade 2 92% Burkitt lymphoma 97% Genetic Familial adenomatous polyposis 99% Tumoral calcinosis 96% Wilson Disease 97% Gynecologic Ovary, clear cell adenocarcinoma 95% Uterus, hydatidiform mole (partial or complete) 88% Endodermal sinus tumor (yolk sac tumor) 97% Serous cystadenoma of low malignant potential 82% Sclerosing stromal tumor 63% Endometrium, late secretory 92% Endometrioid adenocarcinoma of ovary 92% Serous papillary carcinoma of endometrium 50% Simple hyperplasia of the endometrium 45% Chorioamnionitis 98% Placental infarct 82% Sertoli-Leydig cell tumor, poorly differentiated 58% Mucinous carcinoma of low malignant potential 69% Term diamniotic, monochorionic twin placenta 86% Villitis of unknown etiology 69% Leiomyosarcoma 46% CIN III 95% Adenocarcinoma of endometrium 78% Müllerian adenosarcoma of 41% Malignant mesothelium of peritoneum 93% Juvenile granulosa cell tumor of ovary 84% Mature (solid) teratoma 52% Cystadenofibroma of ovary 74% Endometrioid adenocarcinoma 70%

7 Gynecologic Brenner tumor of ovary 90% Carcinosarcoma of endometrium 81% Adnexal tumor of probable Wolffian origin 74% Clear cell carcinoma 83% 93-K2 Simple endometrial hyperplasia 16% Endometrioid carcinoma of the ovary 70% Serous borderline tumor 88% Granulosa cell tumor 96% Immature teratoma, high grade 77% Metastatic colonic adenocarcinoma 53% Chorangioma 98% Granular cell tumor 97% Adenocarcinoma endometrioid, grade III 60% Listeria monocytogenes 88% Lichen sclerosis w/ squamous cell hyperplasia 71% Dysgerminoma 97% Small cell carcinoma 75% Massive diffuse perivillous fibrinoid deposition 64% Mucinous adenoma 91% Myxoid leiomyosarcoma 76% Adenosarcoma 73% Luteoma of pregnancy 86% Uterine papillary serous carcinoma 82% Acute chorioamnionitis 95% Cellular fibroma 35% Metastatic gastric adenocarcinoma 66% Endometrioid tumor of low malignant potential 49% Necrotizing funisitis due to congenital syphilis 89% Sertoli-Leydig cell tumor intermediate-to-poorly differentiated 78% Yolk sac tumor 95% Endometrial stromal sarcoma high grade 73% Adenomatoid tumor 87% Complex endometrial hyperplasia with atypia 74% Hyperreactor luteinalis 86% Borderline (proliferating) Brenner tumor 81% Parvovirus B19 fetopathy with hydrops fetalis 69% Acute lymphoblastic leukemia 28% Serous borderline tumor (serous tumor of low malignant potential) 92% Partial hydatidiform mole 72% Primary transitional cell carcinoma 37% Sex cord tumor with annular tubules 49% Partial hydatidiform mole 72% Primary peritoneal papillary serous carcinoma, low grade 76% Thecoma 37% Clear cell carcinoma 92% Sertoli-Leydig cell tumor w/ granulosa cell tumor and heterologous elements 56% Malignant mixed Müllerian tumor, heterologous type 97% Mucinous tumor of borderline malignancy 96% Low grade endometrial stromal sarcoma with sex cord elements 57% Dysgerminoma 90% Small cell carcinoma 93% Adult granulosa cell tumor 94% Lymphoplasmacytic villitis due to cytomegalovirus infection 74% Pregnancy luteoma 39% Acute bacterial villitis 92% Sclerosing stromal tumor 67% Carcinoid tumor 79%

8 Gynecologic Brenner tumor 87% Endometrioid carcinoma 62% Adenocarcinoma 70% Epithelioid leiomyoma 83% Immature teratoma 90% Mature cystic teratoma 95% Liposarcoma wit myxoid features 72% Hydatidiform mole, complete 82% Endocervical adenomyoma 74% Epithelioid trophoblastic tumor 32% Yolk sac tumor (endodermal sinus tumor) 76% Listeria monocytogenes infection 91% Fallopian tube adenocarcinoma 71% Chorangiomatosis 50% Sertoli-Leydig cell tumor 55% Serous borderline cystadenofibroma 71% Adult granulosa cell tumor 89% Endometrial polyp 85% Metastatic pancreatic adenocarcinoma 65% Leiomyosarcoma 90% Aggressive angiomyxoma 97% Fibroma 87% Juvenile granulosa cell tumor 85% Clear cell carcinoma 62% Mucinous borderline tumor 67% Metastatic gastric carcinoma 77% Mature teratoma 89% Yolk sac tumor (endodermal sinus tumor) 94% Stromal carcinoid 95% Endometrial stromal tumor with sex-cord like elements 89% Serous carcinoma, high grade 91% Acute villitis 73% Ovarian small cell carcinoma, hypercalcemic type 50% Hydrops placentalis 78% Sex cord tumor with annular tubules 72% Carcinosarcoma (malignant mixed Müllerian tumor) 52% Endometrioid adenocarcinoma 56% Brenner tumor 99% Adult granulosa cell tumor 95% Sclerosing stromal tumor 75% Lipoleiomyoma 97% Endometrial stromal sarcoma, low grade 93% Epithelioid leiomyosarcoma 30% Malignant mixed Müllerian tumor 61% Clear cell carcinoma 94% Hepatoid carcinoma 74% Embryonal rhabdomyosarcoma with anaplasia 89% Juvenile granulosa cell tumor 96% Metastatic colorectal adenocarcinoma 98% Chronic villitis secondary to cytomegalovirus infection 98% Serous neoplasm of low malignant potential 95% High grade endometrioid carcinoma, grade 3 94% Endometrial stromal sarcoma, low grade 98% Endometrioid adenocarcinoma 96% Myeloid sarcoma 94% Yolk sac tumor 99% Complete hydatidiform mole 92%

9 Gynecologic Myxoid/round cell liposarcoma 97% Steroid cell tumor, not otherwise specified 89% Adult granulosa cell tumor 93% Dysgerminoma 97% Endometrioid adenocarcinoma 98% Chronic villitis secondary to cytomegalovirus infection 89% Complete hydatidiform mole 93% Complete hydatidiform mole 97% Juvenile granulosa cell tumor 95% Benign Brenner tumor 96% Müllerian adenosarcoma 81% Angiomyofibroblastoma 93% Sclerosing stromal tumor 96% Dysgerminoma 98% Cellular fibrothecoma 87% Endometrial stromal sarcoma 99% Mesenchymal dysplasia 87% Dysgerminoma 99% Head & Neck Heme/Lymphatic Mucoepidermoid carcinoma 97% Warthin's tumor 99% Pleomorphic adenoma (benign mixed tumor) 89% Squamous cell carcinoma of larynx 86% Adenoid cystic carcinoma 96% Benign lymphoepithelial lesion of parotid gland 78% Acinic cell adenocarcinoma 87% Allergic fungal sinusitis 64% Low grade adenocarcinoma (nasopharyngeal papillary adenocarcinoma) 84% Cystic nonkeratinizing squamous cell carcinoma, metastatic to neck lymph node 64% Carcinoma ex-mixed tumor 75% Pleomorphic adenoma 91% Squamous papilloma 89% Acinic cell adenocarcinoma 73% Synovial sarcoma, monophasic 86% Warthin tumor 99% Spindle cell lipoma 69% Extraosseous plasmacytoma 99% Acinic cell carcinoma 99% Basaloid squamous cell carcinoma 97% Reactive follicular hyperplasia, non-specific 97% Diffuse small lymphocytic lymphoma (well-differentiated) 89% Follicular small cleaved cell (nodular poorly differentiated lymphocytic) lymphoma 96% Reactive lymph node hyperplasia 93% Hodgkin disease, nodular sclerosing type 99% Metastatic lobular breast carcinoma in lymph node 91% Diffuse large cell lymphoma 95% Diffuse large cell lymphoma, non-cleaved 50% Metastatic malignant melanoma 66% Cat scratch disease 98% Encapsulated thymoma 75% Carcinoid of the thymus 92% Melanoma in lymph node 87% Nodular lymphoma 68% Castleman's disease 95% Hodgkin disease, nodular sclerosing 95% Hodgkin disease, nodular sclerosing 88%

10 Heme/Lymphatic Burkett lymphoma 91% Malignant lymphoma, non-hodgkin, small non-cleaved cell 78% Large cell malignant lymphoma 74% Malignant lymphoma, mantle cell type 48% Hodgkin disease 88% Hodgkin disease, nodular sclerosis type 99% Malignant lymphoma, diffuse large cell type 73% Hairy cell leukemia of the spleen 91% Idiopathic thrombocytopenia purpura 88% Malignant lymphoma, follicular 60% Malignant lymphoma, MALT type, low grade 63% Castleman's disease 91% Lymphocyte-predominant thymoma 87% Malignant lymphoma, small non-cleaved cell type 57% Thymoma, epithelial predominant (cortical) 95% Malignant lymphoma, mantle cell type, cecum 30% Malignant lymphoma large cell type 57% Marginal zone/malt lymphoma 77% Thymic carcinoma 71% Hodgkin disease, mixed cellularity type 78% Hepatosplenic γδ T-cell lymphoma 82% Extramedullary hematopoiesis of spleen in agnogenic myeloid metaplasia 90% Malignant lymphoma, diffuse, mixed small cleaved and large cell type 72% Infectious mononucleosis 74% Littoral cell angioma 59% Primary amyloidosis, lymph node 66% Prolymphocytic leukemia 40% Anaplastic large cell lymphoma 83% Angiosarcoma, spleen 46% Lymphocyte predominant Hodgkin lymphoma 63% Multiple myeloma 87% Splenic involvement by small lymphocytic lymphoma/chronic lymphocytic N/A Cat scratch disease 96% Extramedullary myeloid tumor 50% Carcinoid tumor consistent with thymic origin 93% Hairy cell leukemia 96% Nodular sclerosis Hodgkin disease 94% Langerhans cell histiocytosis 92% Mantle cell lymphoma 89% Follicular lymphoma 84% Hodgkin lymphoma, nodular sclerosis type 88% Hepatosplenic T-cell lymphoma 86% Mantle cell lymphoma 83% Small lymphocytic lymphoma 88% Typical carcinoid 72% Littoral cell angioma 78% Diffuse large B-cell lymphoma (anaplastic variant) 95% Follicular lymphoma 95% Myeloid sarcoma ( chloroma ) 90% Systemic mastocytosis 93% Classical Hodgkin lymphoma 92% Inflammatory myofibroblastic tumor 94% Acute myeloid leukemia 39% Gaucher disease 92% Thymic carcinoid 97% Angiosarcoma 88% Hepatosplenic T-cell lymphoma 96%

11 Heme/Lymphatic Splenic marginal zone lymphoma Angiofollicular hyperplasia (Castleman disease) 96% Lymphoepithelial thymoma 96% Lymphangioma 85% Paraganglioma 96% Hairy cell leukemia 97% Littoral cell angioma 97% Spindle cell thymoma (WHO type A) 92% Lymphangioma (Lymphatic malformation) 96% Mantle cell lymphoma 83% Low grade fibromyxoid sarcoma with giant collagen rosettes 95% Hairy cell leukemia 97% Niemann-Pick disease 85% Nodular sclerosis classical Hodgkin lymphoma 97% Diffuse large B-cell lymphoma, NOS 98% Viral associated hemophagocytic syndrome 98% Splenic marginal zone lymphoma 91% Follicular dendritic cell sarcoma 97% Gaucher disease 99% Amyloidosis 99% Intra-abdominal desmoplastic small round cell tumor 98% Hepatosplenic T-cell lymphoma 85% Mantle cell lymphoma 99% Hepatobiliary Hepatocellular cellular carcinoma 94% Micronodular cirrhosis, etiology uncertain 97% Focal nodular hyperplasia 93% Chronic passive congestion 99% Primary biliary cirrhosis 71% Focal nodular hyperplasia 91% Hepatocellular carcinoma 95% Cirrhosis 75% Primary sclerosing cholangitis 11% Hepatoblastoma 94% Chronic active hepatitis 89% Hepatocellular carcinoma 27% Acute acetaminophen hepatotoxicity 90% Biliary cystadenoma with mesenchymal stroma 95% Cholangiocarcinoma 78% Fibrolamellar carcinoma 86% Chronic hepatitis C, with mild activity (grade 2) & mild periportal (stage 2) 91% Budd-Chiari syndrome 74% Liver cell adenoma 80% Angiosarcoma 69% Mesenchymal hamartoma 89% Epithelial hepatoblastoma, mixed fetal and embryonal types 39% Fibrolamellar hepatocellular carcinoma 90% Recurrent pyogenic cholangitis 65% Adenocarcinoma 93% Acute myeloid leukemia 93% Amyloidosis 98% Chronic rejection 81% Liver cell carcinoma 80% Primary biliary cirrhosis 92% Embryonal (undifferentiated) sarcoma 89% Hepatocellular adenoma 61%

12 Hepatobiliary Hepatobiliary cystadenoma 60% Focal nodular hyperplasia 91% Mesenchymal hamartoma 98% Congenital hepatic fibrosis 78% Metastatic hemangiopericytoma 58% Focal nodular hyperplasia 83% Hepatoblastoma 93% Mastocytosis 89% Polycystic liver disease 72% Cirrhosis due to alpha-1-antitrypsin deficiency 75% Amyloidosis with biliary-type fibrosis 96% Herpes simplex virus hepatitis 73% Submassive hepatic necrosis 64% Hepatoblastoma 89% Fibrolamellar hepatocellular carcinoma 94% Aggressive systemic mastocytosis 93% Focal nodular hyperplasia 98% Angiosarcoma 95% Cavernous hemangioma 99% Herpes simplex virus hepatitis 95% Hepatocellular carcinoma 98% Alpha-1-antitrypsin deficiency 96% Hepatocellular carcinoma 99% Cholesterolosis 99% Cavernous hemangioma 95% Fibrolamellar carcinoma 97% Congenital hepatic fibrosis 95% Biliary cirrhosis secondary to cystic fibrosis 96% Glycogen storage disease, type IV 97% Hepatoblastoma 99% Alcoholic liver disease with cirrhosis 99% Hepatitis C with alpha-1-antitrypsin intracytoplasmic globules 99% Focal nodular hyperplasia 97% Mesenchymal hamartoma 96% Fibrolamellar hepatocellular carcinoma 99% Angiosarcoma 98%

13 Male Genital Granulomatous prostatitis, non-specific 95% Basal cell hyperplasia of the prostate 96% Granulomatous orchitis (autoimmune orchitis) 90% Cryptorchid testis 95% Seminoma 90% Malignant lymphoma, diffuse, large cell 85% Teratocarcinoma 97% Adenocarcinoma 95% 92-K1 Prostatic adenocarcinoma 69% Idiopathic granulomatous orchitis 87% Seminoma 93% Mixed germ cell neoplasm 68% Sertoli cell adenoma, arising in a patient with complete androgen insensitivity syndrome 73% High grade prostatic intraepithelial neoplasia 91% Adenomatoid tumor 97% Spermatocytic seminoma, testis 77% Immature teratoma, testis 80% Seminoma 96% Spermatocytic seminoma 95% Seminoma 97% Aggressive angiomyxoma 81% Leydig cell tumor 97% Primary testicular lymphoma, diffuse large B-cell type 95% Seminoma 98% Stromal tumor of uncertain malignant potential 88% Nervous System Aggressive angiomyxoma 92% Glioblastoma multiforme (astrocytoma grade III-IV) 98% Meningioma 99% Alzheimer's disease 93% Cerebral infarct, recent, mixed anemic and hemorrhagic 97% Neuroblastoma 95% Oligodendroglioma 55% Ganglioneuroblastoma 84% Transitional meningioma 98% Papillary meningioma 62% Cytomegalovirus ventriculitis 84% HIV encephalitis 65%? Progressive multifocal leukoencephalopathy 67% Cryptococcal meningitis 92% Primary CNS lymphoma 93% Ganglioneuroblastoma, recurrent, lumbar epidural space and retroperitoneum (neuroblastoma also accepted) 83% Acute demyelinating process 58% Dementia with Lewy bodies 32% Subependymal giant cell astrocytoma 85% Cerebral amyloid angiopathy 85% Human prion disease: Subacute spongiform encephalopathy (Creutzfeldt-Jakob disease) 2% Histoplasmosis 74% Gliomatosis cerebri 88% Pilocytic astrocytoma 90% Progressive multifocal leukoencephalopathy 91% Central neurocytoma 72% Aggressive angiomyxoma 92% Oligodendroglioma, WHO grade III 87%

14 Nervous System Desmoplastic infantile astrocytoma/ganglioma 79% Schwannoma 78% Differentiating neuroblastoma 75% Fibrous meningioma 93% West Nile encephalitis 80% Choroid plexus carcinoma 63% Intravascular lymphoma 92% Ependymoma 88% Microcystic meningioma 62% Recurrent high grade astrocytoma with gemistocytic features (WHO grade III-IV) 85% Gliomatosis cerebri (WHO grade III) 85% Paraganglioma of the cauda equine 82% Atypical meningioma (WHO grade II) 33% Pituitary adenoma 98% Chordoid meningioma 95% Anaplastic hemangiopericytoma of the nervous system 90% Gliomatosis cerebri 91% Cortical tuber associated with tuberous sclerosis 88% Malignant peripheral nerve sheath tumor 96% Chordoid meningioma, WHO grade II 95% Oral Path Ameloblastoma 94% Odontogenic keratocyst 53% Central giant cell granuloma 94% Peripheral ossifying fibroma 42% Dentigerous follicular cyst 80% Mucocele 98% Oral lichen planus 85% Ameloblastoma 92% Premalignant epithelial dysplasia 54% Adenoid cystic carcinoma 88% Respiratory Normal lung (kodachrome, FNA) 78% Small cell carcinoma 94% Adenocarcinoma with numerous tumor giant cells 99% Spindle cell variant of squamous cell carcinoma 95% Adenocarcinoma, moderately differentiated 97% Bronchiolo-alveolar carcinoma 79% Pneumocystic carinii pneumonia 98% Squamous cell carcinoma 83% Kaposi sarcoma 96% Measles pneumonia (giant cell pneumonia) with severe diffuse alveolar damage 59% Diffuse alveolar damage 93% Oat cell carcinoma 95% Carcinoid tumor 69% Acute interstitial pneumonia 30% Malignant mesothelioma of pleura 96% Coccidioidomycosis 94% Adenocarcinoma, poorly differentiated 47% Broncho-alveolar adenocarcinoma 77% Actinomycosis 87% Microcystic adenoma 91% Diffuse septal amyloidosis 67% Pulmonary cryptococcosis 93% Acute interstitial pneumonia 46%

15 Respiratory Localized fibrous tumor of pleura 91% Granulomatous lung disease, NOS 65% Adenosquamous carcinoma 75% Giant cell interstitial pneumonia 60% Low grade pleuropulmonary blastoma 25% Herpes simplex pneumonia 73% Solitary fibrous tumor, pleura 82% Malignant mesothelioma, tubulopapillary type 96% Intralobar pulmonary sequestration 86% Silicosis 70% Pulmonary lymphangioleiomyomatosis 85% Pulmonary coccidioidomycosis 84% Kaposi sarcoma 86% Inflammatory myofibroblastic tumor 94% Wegener s granulomatosis 91% Epithelioid hemangioendothelioma 44% Cystic fibrosis 90% Legionella pneumonia 74% Respiratory syncytial virus pneumonia 69% Bronchioloalveolar adenocarcinoma 96% Peripheral primitive neuroectodermal tumor 89% Pulmonary hyperplasia 32% Solitary fibrous tumor 94% Lymphangioleiomyomatosis 89% Thymoma 94% Small cell carcinoma 55% Extranodal marginal zone (MALT) lymphoma 89% Bronchiectasis 82% Pulmonary amyloidosis, diffuse parenchymal type 92% Biphasic pulmonary blastoma 90% Cytomegalovirus pneumonia 85% Bronchioloalveolar carcinoma, mucinous type 92% Solitary fibrous tumor 95% Thymoma 90% Bronchioloalveolar carcinoma, mucinous type 93% Acute lobar pneumonia 86% Malignant solitary fibrous tumor 94% Pulmonary cryptococcosis 91% Follicular dendritic cell tumor/sarcoma 92% Cytomegalovirus pneumonia and Pneumocystis pneumonia 92% Small cell carcinoma 82% Pulmonary adenocarcinoma, mixed subtype 83% Extranodal marginal zone lymphoma, MALT type 98% Squamous cell carcinoma 95% Lymphangioleiomyomatosis 98% Cryptococcosis 98% Recurrent respiratory papillomatosis 93% Alveolar capillary dysplasia 85% Invasive mucinous adenocarcinoma 93% Extranodal marginal zone B-cell lymphoma 99%

16 Skin Pilomatrixoma (calcifying epithelioma of malherbe) 97% Malignant melanoma 81% Congenital nevus 79% Dermatofibrosarcoma protuberans 87% Merkel cell tumor 79% Peripheral neuroectodermal tumor 63% Proliferating trichilemmal cyst 85% Giant congenital melanocytic nevus 80% Extramammary Paget s disease 87% Atypical nevus with mild dysplasia 81% Malignant melanoma 79% Warty dyskeratoma 82% Desmoplastic trichoepithelioma 62% Extramammary Paget s disease 97% Discoid lupus erythematous 90% Cutaneous blastomycosis 84% Merkel cell carcinoma 95% Epithelioid and spindle cell nevus 88% Endometriosis 95% Angiosarcoma 97% Angiosarcoma 93% Condyloma acuminatum 96% Angiosarcoma 87% Nodular melanoma 97% Soft Tissue/Bone/Joint Epithelioid sarcoma 98% Parosteal osteosarcoma 86% Paget's disease 96% Ewing sarcoma 93% Extra abdominal desmoid tumor (fibromatosis) 95% Rheumatoid synovitis 99% Aneurysmal bone cyst 85% Chondrosarcoma 84% Fibrous dysplasia 86% Synovial sarcoma, monophasic 79% Malignant fibrous histiocytoma 86% Lipoma, intramuscular 10% Schwannoma 95% Liposarcoma, high grade 71% Nodular fascitis 90% Myxoid liposarcoma 84% Pleomorphic lipoma/well-differentiated liposarcoma 61% Elastofibroma 89% Rheumatoid nodule 92% Malignant fibrous histiocytoma, storiform-pleomorphic type 87% Well-differentiated liposarcoma 72% Angiolipoma 71% Fibrous dysplasia 59% Schwannoma (neurilemmoma) 65% Lymphangiomyoma 90% Biphasic synovial sarcoma 57% Aggressive angiomyxoma 81% Embryonal rhabdomyosarcoma 85% Osteoarthritis 82% Angiosarcoma 90% Chondrosarcoma 52%

17 Soft Tissue/Bone/Joint Avascular necrosis, osteonecrosis 97% Inflammatory myofibroblastic tumor 89% Intramuscular myxoma 93% Leiomyomatosis peritonealis disseminata 96% Alveolar soft part sarcoma 43% Amyloid tumor 95% Neurofibroma 95% Myxoid/round cell liposarcoma 90% Rhabdomyoma, adult type 90% Chronic synovitis consistent with rheumatoid arthritis 44% Pleomorphic leiomyosarcoma 65% Giant cell fibroblastoma with dermatofibrosarcoma protuberans 68% Chordoma 43% Schwannoma (neurilemmoma), soft tissue 85% Elastofibroma, subscapular area 90% Diffuse malignant mesothelioma 88% Pigmented villonodular synovitis 97% Synovial sarcoma, right parietal pleura 41% Osteosarcoma with grade IIB treatment effect 82% Malignant fibrous histiocytoma 94% Neuroblastoma, poorly differentiated 15% Malignant mesothelioma 21% Desmoid tumor (abdominal fibromatosis) 93% Diffuse neurofibroma 75% Fibrous hamartoma of infancy 89% Extranodal Rosai-Dorfman disease 56% Alveolar soft part sarcoma 93% Myxoid liposarcoma 90% Rhabdomyosarcoma with treatment effect 67% Spindle cell lipoma 84% Multicystic mesothelioma, peritoneum 94% Granular cell tumor of soft tissue 97% Cerebral abscess 89% Myositis ossificans 82% Meningothelial meningioma 85% Extra-abdominal fibromatosis (desmoid tumor) 54% Myxopapillary ependymoma of the filum terminale 71% Hibernoma 96% Juxta-articular myxoma 78% Giant cell tumor 91% Granulomatous inflammation due to Coccidioidomycosis (C. immitis) 65% Clear cell myomelanocytic tumor of hepatic falciform ligament/ligamentum 68% Castleman disease 96% Malignant peripheral nerve sheath tumor 87% Monophasic synovial sarcoma 94% Chondrosarcoma 97% Sclerosing well-differentiated liposarcoma 72% Myxoid/round cell liposarcoma 66% Epithelioid hemangioendothelioma 34% Ewing sarcoma-pnet 94% Incontinentia pigmenti 71% Kimura Disease 93% Pleomorphic hyalinizing angiectatic tumor 95% Synovial chondromatosis 77% Perivascular epithelioid cell tumor (PEComa) 79% Infantile fibrosarcoma 83% Malignant solitary fibrous tumor 62%

18 Soft Tissue/Bone/Joint Elastofibroma 84% Lipoblastoma 82% Malignant peripheral nerve sheath tumor 92% Alveolar soft part sarcoma 95% Intramuscular myxoma 93% Plexiform neurofibroma 88% Myxoid liposarcoma 91% Spindle cell lipoma 94% Ewing sarcoma/primitive neuroectodermal tumor 92% Osteosarcoma 76% Alveolar soft part sarcoma 67% Post radiation osteosarcoma, fibroblastic type 96% Plasmacytoma, extramedullary 93% Metastatic melanoma 99% Angiomyofibroblastoma-like tumor of the male genital tract 84% Malignant mesothelioma 95% Desmoid-type fibromatosis 93% Chondrosarcoma 95% Mammary-type myofibroblastoma 65% Ganglioneuroma 97% Leiomyosarcoma 99% Myxoid liposarcoma 91% Metastatic mucinous adenocarcinoma (mucinous carcinoma peritonei) 97% Schwannoma with degenerative changes 86% Elastofibroma 95% Myxoma 98% Osteosarcoma, chondroblastic type 93% Angiosarcoma 97% Well-differentiated liposarcoma 90% Primary renal Ewing sarcoma/primitive neuroectodermal tumor 90% Intraosseous osteosarcoma, low-grade 87% Glomus tumor 98% Kaposiform hemangioendothelioma 92% Malignant mesothelioma 99% Synovial sarcoma 99% Chondrosarcoma, well-differentiated 96% Kimura lymphadenopathy 91% Infantile fibrosarcoma 92% Ewing sarcoma/primitive neuroectodermal tumor 98% PEComa 94% Intramuscular myxoma 96% Primary synovial chondromatosis 92% Solitary fibrous tumor 98% Castleman disease 99% Alveolar soft part sarcoma 98% Pigmented villonodular synovitis, diffuse-type 92% Paraganglioma 98% Plexiform neurofibroma 97% Hibernoma 99% Myelolipoma 98%

19 Urinary Oncocytoma (grade 1 granular cell neoplasm) 98% Renal cell carcinoma 62% Nephrogenic adenoma (urothelial metaplasia) 72% Mesoblastic nephroma 98% Wilms tumor 94% Xanthogranulomatous pyelonephritis 79% Papillary transitional cell carcinoma 95% Renal cell carcinoma 99% Renal cell carcinoma, sarcomatoid 86% Transplant rejection of kidney, acute 98% Papillary transitional cell carcinoma, non-invasive 87% Congenital mesoblastic nephroma 86% Renal cell carcinoma, chromophobe cell subtype 26% Renal allograft rejection, acute and chronic 57% 95-K2 Focal and segmental glomerulonephritis 78% Myeloma cast nephropathy 94% 96-K1 IGA nephropathy 92% Renal medullary carcinoma 64% Nephroblastoma (Wilms tumor), favorable histology 36% Ethylene glycol nephrotoxicity 80% Invasive transitional cell carcinoma 83% Xanthogranulomatous pyelonephritis 95% Metanephric adenoma 73% Clear cell carcinoma 99% Chromophobe renal cell carcinoma 82% Wilms tumor with diffuse anaplasia 68% Angiomyolipoma 85% Sarcomatoid renal cell carcinoma 78% Urothelial neoplasm of low malignant potential 70% Oncocytoma 91% Clear cell sarcoma 54% Renal cell carcinoma, unclassified 64% Leiomyosarcoma 89% Sarcomatoid urothelial carcinoma 78% Wilms tumor, blastema predominant 84% Pseudosarcomatous reactive myofibroblastic proliferation N/A Mixed epithelial and stromal tumor 40% Oncocytoma 93% Chromophobe renal cell carcinoma 87% Acute cellular rejection with mild chronic transplant nephropathy 78% Leiomyosarcoma 89% Collecting duct carcinoma 92% Embryonal rhabdomyosarcoma, NOS 89% Angiomyolipoma 95% Papillary urothelial carcinoma, low grade 84% Wilms tumor 89% Xanthogranulomatous pyelonephritis 96% Mucinous tubular and spindle cell carcinoma of kidney 51% Congenital mesoblastic nephroma, cellular type 70% Carcinoid tumor 91% Angiomyolipoma 99% Acute cellular allograft rejection 73% Metanephric adenoma 71% Low grade papillary urothelial carcinoma 62% Oncocytoma 96% Chromophobe renal cell carcinoma 97% Papillary renal cell carcinoma 87%

20 Urinary Mixed epithelial and stromal tumor 86% Clear cell renal cell carcinoma 94% Angiomyolipoma 85% Non-invasive papillary urothelial carcinoma 98% Chromophobe renal cell carcinoma 97% Renal cell carcinoma with sarcomatoid component 96% Wilms tumor, favorable histology 94% Renal medullary carcinoma 87% Congenital mesoblastic nephroma 96% Angiomyolipoma 99% Urothelial carcinoma 98% Oncocytoma 98%