Diagnosis of Mesothelioma Pitfalls and Practical Information

Save this PDF as:
 WORD  PNG  TXT  JPG

Size: px
Start display at page:

Download "Diagnosis of Mesothelioma Pitfalls and Practical Information"

Transcription

1 Diagnosis of Mesothelioma Pitfalls and Practical Information Mary Beth Beasley, M.D. Mt Sinai Medical Ctr Dept of Pathology One Gustave L Levy Place New York, NY (212)

2 Mary Beth Beasley, M.D., is an Associate Professor of Pathology at Mt. Sinai Medical Center. She is the author or co-author on over 100 book chapters and peer reviewed articles on various aspects of pulmonary pathology and serves on several national and international committees.

3 Diagnosis of Mesothelioma Pitfalls and Practical Information Table of Contents I. Mesothelial Proliferations Benign or Malignant II. Epithelioid Malignant Mesothelioma III. Sarcomatoid Mesothelioma IV. Summary V. References Diagnosis of Mesothelioma Pitfalls and Practical Information Beasley 1045

4

5 Diagnosis of Mesothelioma Pitfalls and Practical Information I. Mesothelial Proliferations Benign or Malignant a. Determining whether or not a mesothelial proliferation is benign or malignant is one of the most difficult aspects of pleural pathology b. Tissue invasion is the definitive defining feature determining whether or not a proliferation is benign or malignant i. Cytology specimens lack surrounding tissue and extreme caution must be used in interpreting pleural/peritoneal fluid cytology specimens reactive proliferations may look very atypical ii. Pleural biopsy issues 1. Reactive vs neoplastic--epithelioid a. sidedness of proliferation b. Perpendicular blood vessels c. INVASION present or absent 2. Entrapment vs invasion a. Tangential or en face sectioning may lead to the appearance of mesothelial cells within fibrous tissue b.?linear pattern versus infiltrating/irregular /complex growth c. Pitfall Fake fat 3. Pleural fibrosis vs desmoplastic mesothelioma a. Criteria of Mangano, et al. i. Linear vs storiform growth ii. Bland necrosis DMM iii. Invasion of chest wall/lung iv. Frankly sarcomatoid areas v. Distant metastases 4.? Ancillary techniques a. No single immunostain can reliably discriminate a malignant cell from a benign one i. Desmin positive favors reactive over neoplastic ii. P53, GLUT-1, IMP3 positive staining favors malignant over benign b. Homozygous p16 deletion by FISH seen in up to 80% of epithelioid mesotheliomas and close to 100% of sarcomatoid mesotheliomas II. Epithelioid Malignant Mesothelioma a. Differential diagnosis i. Carcinoma usually adenocarcinoma, usually lung origin, other primary sites or origin may be considerations Diagnosis of Mesothelioma Pitfalls and Practical Information Beasley 1047

6 ii. Epithelioid vascular malignancies epithelioid hemangioendotheioma, epithelioid angiosarcoma iii. Malignant melanoma iv. Lymphoma b. Immunostains i. No single immunostain is perfect a panel is recommended to increase sensitivity and specificity ii. Mesothelioma versus adenocarcinoma panel 1. Positive in mesothelioma: calretinin, WT-1, D2-40/podoplanin, CK5/6, thrombomodulin 2. Positive in adenocarcinoma: a. General adenocarcinoma markers: CEA, Leu-M1 (CD15), BER-EP4, B72.3, MOC- 31, BG-8 b. Organ specific markers: TTF-1 (Lung, thyroid),psa (prostate), PSAP(Prostate), cdx-2 (Gastrointestinal), BRST-2/GCDPF-15, mammaglobin (Breast) thyroglobulin (thyroid) iii. Pitfalls 1. Each individual mesothelioma or carcinoma marker may paradoxically stain a small percentage of the opposite tumor. Many of these markers stain tumors other than mesothelioma or adenocarcinoma. Be particularly cautious if a diagnosis is made based on a single marker. 2. Pitfalls of mesothelioma markers a. Calretinin- will stain approx 10% of adenocarcinomas and 40% of squamous carcinomas (usually focal); will also stain certain ovarian tumors and thymomas. b. CK 5/6- Positive in virtually all squamous cell carcinomas (squamous should also be positive for p63 or p40 which is typically negative in mesothelioma) and a significant percentage of breast carcinomas, gynecologic malignancies, pancreatic adenocarcinomas c. WT-1 nuclear stain in mesothelioma; will also stain ovarian serous carcinomas and melanoma i. Additional pitfall stains capillaries and lymphatics which may be mis-interpreted as tumor staining d. D2-40- Stains vascular malignancies, squamous cell carcinomas. i. Similar pitfall to WT-1 with positive background capillaries and lymphatics. 3. Pitfalls of adenocarcinoma markers a. Not every adenocarcinoma will stain for every marker i. Example- CEA is positive in up to 90% of lung carcinomas, which means it will be negative in 10%; additionally, kidney, prostate and ovarian tumors are often negative ii. Issues with renal cell carcinoma 1. Often negative for adenocarcinoma markers 1048 Asbestos Medicine November 2014

7 2. Markers often used for renal cell such as CD10 and RCC-Ma may be positive in mesothelioma 3. Newer markers PAX-8, PAX-2 so far negative in renal cell 4. Renal cell rarely positive for WT-1, negative for calretinin, CK5/6 and D Malignant vascular tumors may be positive for keratin and will be positive for D2-40; will be positive for other vascular markers such as CD31, CD34, ERG and FLI-1 5. Lymphoma maybe in differential of lymphohistiocytoid variant of mesothelioma in particular 6. Melanoma Small percentage may be positive for low molecular weight cytokeratin but is generally negative. Will be positive for WT-1 either nuclear or cytoplasmic. Positive for S-100, HMB-45, melan-a 7. Other-Primitive neuroectodermal tumor (PNET), desmoplastic small round cell tumor III. Sarcomatoid Mesothelioma a. Differential diagnosis i. Sarcomatoid carcinoma most problematic 1. Sarcomatoid mesothelioma diffuse pleural involvement or multiple pleural nodules; positive for cytokeratin, variable percentage positive for calretinin, WT-1, D2-40; CK5/6 generally negative 2. Sarcomatoid carcinoma large parenchymal mass only rare reports of distribution similar to meso; positive for keratin, usually negative for other carcinoma markers. 3. Stains may be helpful but disease distribution is critical, especially if only keratin is positive 4. Metastatic sarcomatoid carcinomas involving the pleura i.e sarcomatoid renal cell carcinoma may be impossible to sort out without appropriate radiology. ii. Sarcomas 1. Synovial sarcoma may be positive for cytokeratin and calretinin; t(x;18) translocation useful in problematic cases 2. Others liposarcoma, leiomyosarcoma, etc rare iii. Solitary fibrous tumor localized as opposed to diffuse involvement, negative keratin, positive CD34, bcl-2 usually only an issue in a small biopsy without clinical or radiographic information. IV. Summary a. In all situations, evaluation must be made in the context of tissue morphology, stains and clinical/ radiographic information b. Potential red flags to look for in a mesothelioma diagnosis i. Diagnosis made based on only one positive immunostain ii. Inappropriate disease distribution for mesothelioma Diagnosis of Mesothelioma Pitfalls and Practical Information Beasley 1049

8 V. References 1: Husain AN, Colby T, Ordonez N, Krausz T, Attanoos R, Beasley MB, Borczuk AC, Butnor K, Cagle PT, Chirieac LR, Churg A, Dacic S, Fraire A, Galateau-Salle F, Gibbs A, Gown A, Hammar S, Litzky L, Marchevsky AM, Nicholson AG, Roggli V,Travis WD, Wick M; International Mesothelioma Interest Group. Guidelines for pathologic diagnosis of malignant mesothelioma: 2012 update of the consensus statement from the International Mesothelioma Interest Group. Arch Pathol Lab Med May;137(5): : Churg A, Cagle P, Colby TV, Corson JM, Gibbs AR, Hammar S, Ordonez N, Roggli VL, Tazelaar HD, Travis WD, Wick M; US-Canadian Mesothelioma Reference Panel. The fake fat phenomenon in organizing pleuritis: a source of confusion with desmoplastic malignant mesotheliomas. Am J Surg Pathol Dec;35(12): : Churg A, Galateau-Salle F. The separation of benign and malignant mesothelial proliferations. Arch Pathol Lab Med Oct;136(10): : Tochigi N, Attanoos R, Chirieac LR, Allen TC, Cagle PT, Dacic S. p16 Deletion in sarcomatoid tumors of the lung and pleura. Arch Pathol Lab Med May;137(5): : Guinee DG, Allen TC. Primary pleural neoplasia: entities other than diffuse malignant mesothelioma. Arch Pathol Lab Med Jul;132(7): : Mangano WE, Cagle PT, Churg A, Vollmer RT, Roggli VL. The diagnosis of desmoplastic malignant mesothelioma and its distinction from fibrous pleurisy: a histologic and immunohistochemical analysis of 31 cases including p53 immunostaining. Am J Clin Pathol Aug;110(2): Asbestos Medicine November 2014

MALIGNANT MESOTHELIOMA UPDATE ON PATHOLOGY AND IMMUNOHISTOCHEMISTRY

MALIGNANT MESOTHELIOMA UPDATE ON PATHOLOGY AND IMMUNOHISTOCHEMISTRY MALIGNANT MESOTHELIOMA UPDATE ON PATHOLOGY AND IMMUNOHISTOCHEMISTRY Sisko Anttila, MD, PhD Jorvi Hospital Laboratory of Pathology Helsinki University Hospital Espoo, Finland 2nd Nordic Conference on Applied

More information

MALIGNANT MESOTHELIOMA UPDATE ON PATHOLOGY AND IMMUNOHISTOCHEMISTRY

MALIGNANT MESOTHELIOMA UPDATE ON PATHOLOGY AND IMMUNOHISTOCHEMISTRY MALIGNANT MESOTHELIOMA CLASSIFICATION MALIGNANT MESOTHELIOMA UPDATE ON PATHOLOGY AND IMMUNOHISTOCHEMISTRY Sisko Anttila, MD, PhD Jorvi Hospital Laboratory of Pathology Helsinki University Hospital Espoo,

More information

Update on Mesothelioma

Update on Mesothelioma November 8, 2012 Update on Mesothelioma Intro incidence and nomenclature Update on Classification Diagnostic specimens Morphologic features Epithelioid Histology Biphasic Histology Immunohistochemical

More information

Case of the. Month October, 2012

Case of the. Month October, 2012 Case of the Month October, 2012 Case The patient is a 47-year-old male with a 3-week history of abdominal pain. A CT scan of the abdomen revealed a suggestion of wall thickening at the tip of the appendix

More information

Notice of Faculty Disclosure

Notice of Faculty Disclosure The Diagnosis of Malignant Mesothelioma Andrew Churg, MD Department of Pathology University of British Columbia Vancouver, BC, Canada achurg@mail.ubc.ca Notice of Faculty Disclosure In accordance with

More information

PATHOLOGY OF THE PLEURA: Mesothelioma and mimickers Necessity of Immunohistochemistry. M. Praet

PATHOLOGY OF THE PLEURA: Mesothelioma and mimickers Necessity of Immunohistochemistry. M. Praet PATHOLOGY OF THE PLEURA: Mesothelioma and mimickers Necessity of Immunohistochemistry M. Praet Pathology of the Pleura Normal serosa: visceral and parietal layers Inflammation Neoplasia: Primary: mesothelioma

More information

Practical Effusion Cytology

Practical Effusion Cytology Practical Effusion Cytology A Community Pathologist s Approach to Immunocytochemistry in Body Fluid Cytology Emily E. Volk, MD William Beaumont Hospital Troy, MI College of American Pathologists 2004.

More information

The develpemental origin of mesothelium

The develpemental origin of mesothelium Mesothelioma Tallinn 14.12.06 Henrik Wolff Finnish Institute of Occupational Health The develpemental origin of mesothelium Mesodermal cavities (pleura, peritoneum and pericardium ) are lined with mesenchymal

More information

Outline. Workup for metastatic breast cancer. Metastatic breast cancer

Outline. Workup for metastatic breast cancer. Metastatic breast cancer Metastatic breast cancer Immunostain Update: Diagnosis of metastatic breast carcinoma, emphasizing distinction from GYN primary 1/3 of breast cancer patients will show metastasis 1 st presentation or 20-30

More information

Académie internationale de Pathologie - Division arabe XX ème congrès 24-26 novembre 2008 Alger. Immunohistochemistry in malignant mesotheliomas

Académie internationale de Pathologie - Division arabe XX ème congrès 24-26 novembre 2008 Alger. Immunohistochemistry in malignant mesotheliomas Académie internationale de Pathologie - Division arabe XX ème congrès 24-26 novembre 2008 Alger Immunohistochemistry in malignant mesotheliomas Françoise Thivolet-Béjui Groupement Hospitalier Est Lyon-Bron

More information

Case based applications part III

Case based applications part III Case based applications part III Los Angeles Society Of Pathologists January 25, 2014 Sanja Dacic, MD, PhD University of Pittsburgh Medical Center 1 CASE 1 A 44-year-old woman with multiple lung nodules.

More information

Seattle. Case Presentations. Case 1. 76 year old female with a history of breast cancer 12 years ago. Now presents with a pleural effusion.

Seattle. Case Presentations. Case 1. 76 year old female with a history of breast cancer 12 years ago. Now presents with a pleural effusion. Seattle Montreal IAP September 2006 Case Presentations Allen M. Gown, M.D. Medical Director and Chief Pathologist PhenoPath Laboratories Clinical Professor of Pathology University of British Columbia Case

More information

Immunohistochemistry on cytology specimens from pleural and peritoneal fluid

Immunohistochemistry on cytology specimens from pleural and peritoneal fluid Immunohistochemistry on cytology specimens from pleural and peritoneal fluid Dr Naveena Singh Consultant Pathologist Bart health NHS Trust London United Kingdom Disclosures and Acknowledgements I have

More information

3-F. Pathology of Mesothelioma

3-F. Pathology of Mesothelioma 3-F. Pathology of Mesothelioma Kouki Inai Professor of Department of Pathology, Graduate School of Biomedical Science, Hiroshima University Introduction Mesothelioma is a peculiar type of malignancy, which

More information

Immunohistochemical differentiation of metastatic tumours

Immunohistochemical differentiation of metastatic tumours Immunohistochemical differentiation of metastatic tumours Dr Abi Wheal ST1. TERA 3/2/14 Key points from a review article written by Daisuke Nonaka Intro Metastatic disease is the initial presentation in

More information

Ovarian tumors Ancillary methods

Ovarian tumors Ancillary methods Ovarian tumors Ancillary methods Ovarian tumor course Oslo, 24-25/11/14 Prof. Ben Davidson, MD PhD Department of Pathology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway Division of

More information

Recommendations for the Reporting of Pleural Mesothelioma

Recommendations for the Reporting of Pleural Mesothelioma Recommendations for the Reporting of Pleural Mesothelioma Association of Directors of Anatomic and Surgical Pathology * DOI: 10.1309/6A30YQHBMTHEJTEM It has been evident for decades that pathology reports

More information

Disclosures. Learning Objectives. Effusion = Confusion. Diagnosis Of Serous Cavity Effusions - Beware The Mesothelial Cell!

Disclosures. Learning Objectives. Effusion = Confusion. Diagnosis Of Serous Cavity Effusions - Beware The Mesothelial Cell! Disclosures Diagnosis Of Serous Cavity Effusions - Beware The Mesothelial Cell! No Relevant Financial Relationships with Commercial Interests Syed Z. Ali, M.D. Syed Z. Ali, M.D. Associate Professor of

More information

20 Diagnostic Cytopathology, Vol 36, No 1 ' 2007 WILEY-LISS, INC.

20 Diagnostic Cytopathology, Vol 36, No 1 ' 2007 WILEY-LISS, INC. Utility of WT-1, p63, MOC31, Mesothelin, and Cytokeratin (K903 and CK5/6) Immunostains in Differentiating Adenocarcinoma, Squamous Cell Carcinoma, and Malignant Mesothelioma in Effusions Robert T. Pu,

More information

Effusions: Mesothelioma and Metastatic Cancers

Effusions: Mesothelioma and Metastatic Cancers Effusions: Mesothelioma and Metastatic Cancers Malignant Mesothelioma Incidence: 2,500 cases/year ~60-80% pts with pleural MM relationship with asbestos exposure Other risk factors: radiation, other carcinogens,

More information

Diagnosis Of Serous Cavity Effusions - Beware The Mesothelial Cell! Effusion = Confusion

Diagnosis Of Serous Cavity Effusions - Beware The Mesothelial Cell! Effusion = Confusion Diagnosis Of Serous Cavity Effusions - Beware The Mesothelial Cell! Effusion = Confusion Syed Z. Ali, M.D. Professor of Pathology and Radiology The Johns Hopkins Hospital Baltimore, Maryland Diagnostic

More information

Diagnostic Challenge. Department of Pathology,

Diagnostic Challenge. Department of Pathology, Cytology of Pleural Fluid as a Diagnostic Challenge Paavo Pääkkö,, MD, PhD Chief Physician and Head of the Department Department of Pathology, Oulu University Hospital,, Finland Oulu University Hospital

More information

Cytological Diagnosis of Malignant Pleural Mesothelioma: A Cautionary Note for Lawyers in Asbestos Litigation

Cytological Diagnosis of Malignant Pleural Mesothelioma: A Cautionary Note for Lawyers in Asbestos Litigation Cytological Diagnosis of Malignant Pleural Mesothelioma: A Cautionary Note for Lawyers in Asbestos Litigation Edward Casmere and Joshua Lee Law360 March 7, 2014 For a variety of reasons, lawyers in asbestos

More information

Cytology : first alert of mesothelioma? Professor B. Weynand, UCL Yvoir, Belgium

Cytology : first alert of mesothelioma? Professor B. Weynand, UCL Yvoir, Belgium Cytology : first alert of mesothelioma? Professor B. Weynand, UCL Yvoir, Belgium Introduction 3 cavities with the same embryologic origin the mesoderme Pleura Exudates Pleura Peritoneum Pericardium 22%

More information

Renal Cell Carcinoma: Advances in Diagnosis B. Iványi, MD

Renal Cell Carcinoma: Advances in Diagnosis B. Iványi, MD Renal Cell Carcinoma: Advances in Diagnosis B. Iványi, MD Department of Pathology University of Szeged, Hungary ISUP Vancouver Classification of Renal Neoplasia Am J Surg Pathol 37:14691489, 2013 13 histologic

More information

Today s Topics. Tumors of the Peritoneum in Women

Today s Topics. Tumors of the Peritoneum in Women Today s Topics Tumors of the Peritoneum in Women Charles Zaloudek, M.D. Department of Pathology 505 Parnassus Ave., M563 University of California, San Francisco San Francisco, CA USA charles.zaloudek@ucsf.edu

More information

The Value of Thyroid Transcription Factor-1 in Cytologic Preparations as a Marker for Metastatic Adenocarcinoma of Lung Origin

The Value of Thyroid Transcription Factor-1 in Cytologic Preparations as a Marker for Metastatic Adenocarcinoma of Lung Origin Anatomic Pathology / TTF-1 IN CYTOLOGY OF BODY FLUIDS The Value of Thyroid Transcription Factor-1 in Cytologic Preparations as a Marker for Metastatic Adenocarcinoma of Lung Origin Jonathan L. Hecht, MD,

More information

2011 Pulmonary Pathology Society Biennial Meeting Program

2011 Pulmonary Pathology Society Biennial Meeting Program 2011 Pulmonary Pathology Society Biennial Meeting Program Thursday, August 18, 2011 7:00 AM Registration and Continental Breakfast 7:45 AM Welcome: Donald Guinee / Elisabeth Brambilla 8:00 AM Interstitial

More information

Cytopathology Case Presentation #8

Cytopathology Case Presentation #8 Cytopathology Case Presentation #8 Emily E. Volk, MD William Beaumont Hospital, Troy, MI Jonathan H. Hughes, MD Laboratory Medicine Consultants, Las Vegas, Nevada Clinical History 44 year old woman presents

More information

Protocol for the Examination of Specimens From Patients With Malignant Pleural Mesothelioma

Protocol for the Examination of Specimens From Patients With Malignant Pleural Mesothelioma Protocol for the Examination of Specimens From Patients With Malignant Pleural Mesothelioma Based on AJCC/UICC TNM, 7th edition Protocol web posting date: February 1, 2011 Procedures Resection Authors

More information

CASE OF THE MONTH AUGUST-2015 DR. GURUDUTT GUPTA HEAD HISTOPATHOLOGY

CASE OF THE MONTH AUGUST-2015 DR. GURUDUTT GUPTA HEAD HISTOPATHOLOGY CASE OF THE MONTH AUGUST-2015 DR. GURUDUTT GUPTA HEAD HISTOPATHOLOGY CASE HISTORY 52Y MALE RIGHT RADICAL NEPHERECTOMY Case of right renal mass with IVC thrombus. History of surgery and RT for right occipital

More information

A Cytokeratin- and Calretinin-negative Staining Sarcomatoid Malignant Mesothelioma

A Cytokeratin- and Calretinin-negative Staining Sarcomatoid Malignant Mesothelioma A Cytokeratin- and Calretinin-negative Staining Sarcomatoid Malignant Mesothelioma MICHAEL G. HURTUK and MICHELE CARBONE Cardinal Bernadin Cancer Center, Cancer Immunology Program, Department of Pathology,

More information

TUMORS OF THE TESTICULAR ADNEXA and SPERMATIC CORD

TUMORS OF THE TESTICULAR ADNEXA and SPERMATIC CORD TUMORS OF THE TESTICULAR ADNEXA and SPERMATIC CORD Victor E. Reuter, MD Memorial Sloan-Kettering Cancer Center reuterv@mskcc.org 66 th Annual Pathology Seminar California Society of Pathologists Short

More information

A 70-year old Man with Pleural Effusion

A 70-year old Man with Pleural Effusion Mesothelioma Diagnosis: Pitfalls and Latest Updates S Klebe and DW Henderson Recommendations Indisputable malignant cells on cytomorphological criteria which demonstrate a mesothelial phenotype, which

More information

HKCPath Anatomical Pathology Peer Review and Scores : PDF version for download

HKCPath Anatomical Pathology Peer Review and Scores : PDF version for download AP2003R1 http://hkcpath.org. Correspondence: pkhui@ha.org.hk 1of 10 07/08/2003 HKCPath Anatomical Pathology Peer Review and Scores : PDF version for download AP141 Bone Marrow: Metastatic Carcinoma from

More information

PRIMARY SEROUS CARCINOMA OF PERITONEUM: A CASE REPORT

PRIMARY SEROUS CARCINOMA OF PERITONEUM: A CASE REPORT PRIMARY SEROUS CARCINOMA OF PERITONEUM: A CASE REPORT Dott. Francesco Pontieri (*) U.O. di Anatomia Patologica P.O. di Rossano (CS) Dott. Gian Franco Zannoni Anatomia Patologica Facoltà di Medicina e Chirurgia

More information

Case 1 (TV13-74) TV Colby MD

Case 1 (TV13-74) TV Colby MD Case 1 (TV13-74) TV Colby MD Mesothelioma?? Why is this not a mesothelioma?? Differential Diagnosis: Mesothelioma Metastatic Carcinoma Lung, thyroid, other Case 1 History 61F History of cardiomyopathy

More information

Effusions of the Serous Cavities

Effusions of the Serous Cavities Effusions of the Serous Cavities Annika Dejmek Professor/Consultant in Cytopathology Clinical Pathology; Department of Laboratory Medicine, Malmö, Lund University 5th EFCS Tutorial Trondheim 2012 Pleura

More information

Original Article Differential diagnosis of sarcomatoid mesothelioma from true sarcoma and sarcomatoid carcinoma using immunohistochemistry

Original Article Differential diagnosis of sarcomatoid mesothelioma from true sarcoma and sarcomatoid carcinoma using immunohistochemistry Pathology International 2008; 58: 75 83 doi:10.1111/j.1440-1827.2007.02193.x Original Article Differential diagnosis of sarcomatoid mesothelioma from true sarcoma and sarcomatoid carcinoma using immunohistochemistry

More information

Index. F Factor VIII-related antigen, see VWF FactorXIIIa, for dermatofibroma, 272-275 5-HT, see Serotonin

Index. F Factor VIII-related antigen, see VWF FactorXIIIa, for dermatofibroma, 272-275 5-HT, see Serotonin A Acantholytic squamous cell carcinoma vs epithelioid angiosarcoma, 56-57 Acinic cell carcinoma of pancreas, 76-77 vs ductal adenocarcinoma, 74-75 vs islet cell tumor, 78-81 Adenomatoid tumor vs hemangioma,

More information

The evolving pathology of solitary fibrous tumours. Luciane Dreher Irion MREH / CMFT / NSOPS

The evolving pathology of solitary fibrous tumours. Luciane Dreher Irion MREH / CMFT / NSOPS The evolving pathology of solitary fibrous tumours Luciane Dreher Irion MREH / CMFT / NSOPS Historical review Haemangiopericytoma (HPC) first described primarily as a soft tissue vascular tumour of pericytic

More information

Lessons from a consultation practice

Lessons from a consultation practice Pitfalls in the Application of Immunohistochemistry in Diagnostic Pathology Lessons from a consultation practice Kevin O. Leslie, MD Professor and Consultant Mayo Clinic Arizona Scottsdale, Arizona Presenter

More information

Changes in Breast Cancer Reports After Second Opinion. Dr. Vicente Marco Department of Pathology Hospital Quiron Barcelona. Spain

Changes in Breast Cancer Reports After Second Opinion. Dr. Vicente Marco Department of Pathology Hospital Quiron Barcelona. Spain Changes in Breast Cancer Reports After Second Opinion Dr. Vicente Marco Department of Pathology Hospital Quiron Barcelona. Spain Second Opinion in Breast Pathology Usually requested when a patient is referred

More information

Malignant Mesothelioma Diagnosed by Bronchoscopic Biopsy

Malignant Mesothelioma Diagnosed by Bronchoscopic Biopsy CASE REPORT http://dx.doi.org/10.4046/trd.2015.78.3.297 ISSN: 1738-3536(Print)/2005-6184(Online) Tuberc Respir Dis 2015;78:297-301 Malignant Mesothelioma Diagnosed by Bronchoscopic Biopsy Yeon-Hee Park,

More information

Abstract. Introduction. Material and Methods

Abstract. Introduction. Material and Methods Original Article Expression of Mesothelial Markers in Malignant Mesotheliomas: an Immunohistochemical Evaluation of 173 Cases I.N. Soomro, R. Oliveira*, J. Ronan, Z. R. Chaudry, J. Johnson Department of

More information

Immunohistochemistry of soft tissue tumors

Immunohistochemistry of soft tissue tumors Immunohistochemistry of soft tissue tumors Immunohistochemistry Major advances : antigen retrieval techniques (HIER) sensitive detection systems numerous antibodies of good quality Standardization : automated

More information

MALIGNANT MESOTHELIOMA: A TYPICAL PRESENTATION IN AN ATYPICAL PATIENT

MALIGNANT MESOTHELIOMA: A TYPICAL PRESENTATION IN AN ATYPICAL PATIENT MALIGNANT MESOTHELIOMA: A TYPICAL PRESENTATION IN AN ATYPICAL PATIENT Written by: Karyn Varley MS, SCT(ASCP) The donating laboratory would like to remain anonymous. PATIENT HISTORY 28 year old female Lived

More information

INFLAMMATORY PLEURAL EFFUSION

INFLAMMATORY PLEURAL EFFUSION PLEURA- LESIONS LESIONS OF PLEURA Primary Intra pleural bacterial infections Neoplasm (mesothelioma) Secondary A complication of some underlying disease PLEURAL EFFUSION Common manifestation of both primary

More information

Problem Cases in Surgical Pathology XXV Congreso de la Sociedad Española de Patologia (SEAP) - Zaragoza, Mayo 18-21, 2011.

Problem Cases in Surgical Pathology XXV Congreso de la Sociedad Española de Patologia (SEAP) - Zaragoza, Mayo 18-21, 2011. Problem Cases in Surgical Pathology XXV Congreso de la Sociedad Española de Patologia (SEAP) - Zaragoza, Mayo 18-21, 2011. Saul Suster, M.D. Medical College of Wisconsin Milwaukee, WI, USA Case - 2 Clinical

More information

Like diffuse malignant mesothelioma (DMM), metastatic

Like diffuse malignant mesothelioma (DMM), metastatic Expression of Renal Cell Carcinoma Associated Markers Erythropoietin, CD10, and Renal Cell Carcinoma Marker in Diffuse Malignant Mesothelioma and Metastatic Renal Cell Carcinoma Kelly J. Butnor, MD; Andrew

More information

Case presentation: Mesothelioma of the tunica vaginalis. Dr Ben Shepherd Pathology Queensland Princess Alexandra Hospital Brisbane

Case presentation: Mesothelioma of the tunica vaginalis. Dr Ben Shepherd Pathology Queensland Princess Alexandra Hospital Brisbane Case presentation: Mesothelioma of the tunica vaginalis Dr Ben Shepherd Pathology Queensland Princess Alexandra Hospital Brisbane A 76 year old man presented June 2011 with a 6 month history of painless

More information

Diseases. Inflammations Non-inflammatory pleural effusions Pneumothorax Tumours

Diseases. Inflammations Non-inflammatory pleural effusions Pneumothorax Tumours Pleura Visceral pleura covers lungs and extends into fissures Parietal pleura limits mediastinum and covers dome of diaphragm and inner aspect of chest wall. Two layers between them (pleural cavity) contains

More information

Abstracts and References

Abstracts and References Abstracts and References Soft Tissue Pathology Professor Cyril Fisher, Royal Marsden Hospital Learning points CD34 and CK positivity coexist in epithelioid sarcoma and epithelioid endothelial tumours.

More information

Case Report Epithelioid malignant mesothelioma presenting with features of gastric tumor in a child

Case Report Epithelioid malignant mesothelioma presenting with features of gastric tumor in a child Int J Clin Exp Pathol 2014;7(5):2636-2640 www.ijcep.com /ISSN:1936-2625/IJCEP0000187 Case Report Epithelioid malignant mesothelioma presenting with features of gastric tumor in a child Qihan You 1, Jing

More information

Introduction: Tumor Swelling / new growth / mass. Two types of growth disorders: Non-Neoplastic. Secondary / adaptation due to other cause.

Introduction: Tumor Swelling / new growth / mass. Two types of growth disorders: Non-Neoplastic. Secondary / adaptation due to other cause. Disorders of Growth Introduction: Tumor Swelling / new growth / mass Two types of growth disorders: Non-Neoplastic Secondary / adaptation due to other cause. Neoplastic. Primary growth abnormality. Non-Neoplastic

More information

Plueral Malignancy: Radiologic-pathologic

Plueral Malignancy: Radiologic-pathologic Plueral Malignancy: Radiologic-pathologic Correlation Ritu R. Gill, MD Pleural Malignancies: Radiologic-Pathologic Correlation Ritu R Gill MD Brigham and Women s Hospital Boston, Massachusetts Pleural

More information

DESMOPLASTIC SMALL ROUND CELL TUMOR: A RARE PATHOLOGY PUZZLE

DESMOPLASTIC SMALL ROUND CELL TUMOR: A RARE PATHOLOGY PUZZLE DESMOPLASTIC SMALL ROUND CELL TUMOR: A RARE PATHOLOGY PUZZLE Ryan Granger University of Rhode Island Cytotechnology program May 2, 2015 ASCT Annual Meeting Nashville, Tennessee DESMOPLASTIC SMALL ROUND

More information

Pathology of lung cancer

Pathology of lung cancer Pathology of lung cancer EASO COURSE ON LUNG CANCER AND MESOTHELIOMA DAMASCUS (SYRIA), MAY 3-4, 2007 Gérard ABADJIAN MD Pathologist Associate Professor, Saint Joseph University Pathology Dept. Hôtel-Dieu

More information

Protocol applies to all primary borderline and malignant epithelial tumors, and malignant mesothelial neoplasms of the peritoneum.

Protocol applies to all primary borderline and malignant epithelial tumors, and malignant mesothelial neoplasms of the peritoneum. Peritoneum Protocol applies to all primary borderline and malignant epithelial tumors, and malignant mesothelial neoplasms of the peritoneum. Protocol revision date: January 2004 No AJCC/UICC staging system

More information

Distinguishing benign from malignant mesothelial

Distinguishing benign from malignant mesothelial ORIGINAL ARTICLE IMP3 and GLUT-1 Immunohistochemistry for Distinguishing Benign From Malignant Mesothelial Proliferations Anna F. Lee, MDCM, PhD,*w Allen M. Gown, MD,wz and Andrew Churg, MD*w Abstract:

More information

Video Microscopy Tutorial 5

Video Microscopy Tutorial 5 Video Microscopy Tutorial 5 Lool Alikes in Effusion Cytology:Review of Diagnostic Challenges Claire Michael, MD There are no disclosures necessary. Look-Alikes in Effusion Cytology: Review of Diagnostic

More information

The diagnostic usefulness of tumour markers CEA and CA-125 in pleural effusion

The diagnostic usefulness of tumour markers CEA and CA-125 in pleural effusion Malaysian J Path01 2002; 24(1) : 53-58 The diagnostic usefulness of tumour markers CEA and CA-125 in pleural effusion Pavai STHANESHWAR MD, Sook-Fan YAP FRCPath, FRCPA and Gita JAYARAM MDPath, MRCPath

More information

Pleural Mesothelioma: An Institutional Experience of 66 Cases

Pleural Mesothelioma: An Institutional Experience of 66 Cases The Korean Journal of Pathology 2014; 48: 91-99 ORIGINAL ARTICLE Pleural Mesothelioma: An Institutional Experience of 66 Cases Soomin Ahn In Ho Choi Joungho Han Jhingook Kim 1 Myung-Ju Ahn 2 Departments

More information

Case presentation. Awatif Al-Nafussi

Case presentation. Awatif Al-Nafussi Case presentation Awatif Al-Nafussi Case History 49 year old DVT & small PE June 08, Pelvic mass Ca125 33 Laparotomy-TAHBSO, drainage of ascites Ovarian carcinoma Clinical diagnosis Multiple specimens

More information

October 2012 Pulmonary Case of the Month: Hemoptysis from an Uncommon Cause. Lewis J. Wesselius, MD

October 2012 Pulmonary Case of the Month: Hemoptysis from an Uncommon Cause. Lewis J. Wesselius, MD October 2012 Pulmonary Case of the Month: Hemoptysis from an Uncommon Cause Lewis J. Wesselius, MD Department of Pulmonary Medicine Mayo Clinic Arizona Scottsdale, AZ History of Present Illness A 39 year

More information

Diagnosis of Synovial Sarcoma of the Pleura and Differentiation from Malignant Mesothelioma

Diagnosis of Synovial Sarcoma of the Pleura and Differentiation from Malignant Mesothelioma 36 Diagnosis of Synovial Sarcoma of the Pleura and Differentiation from Malignant Mesothelioma Amy Powers and Michele Carbone Synovial sarcomas (SSs) are soft tissue tumors that occur primarily in adolescents

More information

DIFFICULTIES IN THE PATHOLOGIC DIAGNOSIS OF LUNG CANCER Notice of Financial Disclosures (TV Colby MD) (Esp. in small biopsies) Personal Experience Thomas V. Colby, M.D. Mayo Clinic Arizona NONE This talk

More information

No Difference Between Mesothelioma and Pulmonary and Nonpulmonary Adenocarcinoma DO NOT DUPLICATE. Malignancy is a common cause of effusions of the

No Difference Between Mesothelioma and Pulmonary and Nonpulmonary Adenocarcinoma DO NOT DUPLICATE. Malignancy is a common cause of effusions of the NONGYNECOLOGIC CYTOPTHOLOGY CK5/6 in Effusions No Difference etween Mesothelioma and Pulmonary and Nonpulmonary denocarcinoma nnika Dejmek, M.D., Ph.D. Objective To test the performance of CK5/6 for the

More information

The Diagnosis of Cancer in the Pathology Laboratory

The Diagnosis of Cancer in the Pathology Laboratory The Diagnosis of Cancer in the Pathology Laboratory Dr Edward Sheffield Christmas Select 74 Meeting, Queen s Hotel Cheltenham, 3 rd December 2014 Agenda Overview of the pathology of cancer How specimens

More information

Lung Carcinomas New 2015 WHO Classification. Spasenija Savic Pathology

Lung Carcinomas New 2015 WHO Classification. Spasenija Savic Pathology Lung Carcinomas New 2015 WHO Classification Spasenija Savic Pathology ***EXPECTED SPRING 2015*** This authoritative, concise reference book provides an international standard for oncologists and pathologists

More information

Protocol for the Examination of Specimens From Patients With Tumors of the Peritoneum

Protocol for the Examination of Specimens From Patients With Tumors of the Peritoneum Protocol for the Examination of Specimens From Patients With Tumors of the Peritoneum Protocol applies to all primary borderline and malignant epithelial tumors and malignant mesothelial neoplasms of the

More information

CYTOPATHOLOGY OF THE LIVER Gladwyn Leiman

CYTOPATHOLOGY OF THE LIVER Gladwyn Leiman 23 rd Annual Cytology Conference Pittsburgh PA CYTOPATHOLOGY OF THE LIVER Gladwyn Leiman OUTLINE MICROSCOPY Normal constituents HCC and other primary liver tumors Selected important metastatic tumors Benign

More information

BY THE NUMBERS: THE FUTURE OF MESOTHELIOMA IN AMERICA

BY THE NUMBERS: THE FUTURE OF MESOTHELIOMA IN AMERICA BY THE NUMBERS: THE FUTURE OF MESOTHELIOMA IN AMERICA 1 CUTTING-EDGE ISSUES IN ASBESTOS LITIGATION CONFERENCE Scott Masterson Lewis, Brisbois, Bisgaard & Smith, LLP 1180 Peachtree Street, NE, Suite 2900

More information

Standards and datasets for reporting cancers. Dataset for the histological reporting of mesothelioma. April 2013

Standards and datasets for reporting cancers. Dataset for the histological reporting of mesothelioma. April 2013 Standards and datasets for reporting cancers Dataset for the histological reporting of mesothelioma April 2013 Authors Professor Andrew G Nicholson, Royal Brompton Hospital and Harefield NHS Trust Professor

More information

Objectives. Mylene T. Truong, MD. Malignant Pleural Mesothelioma Background

Objectives. Mylene T. Truong, MD. Malignant Pleural Mesothelioma Background Imaging of Pleural Tumors Mylene T. Truong, MD Imaging of Pleural Tumours Mylene T. Truong, M. D. University of Texas M.D. Anderson Cancer Center, Houston, TX Objectives To review tumors involving the

More information

264 Diagnostic Cytopathology, Vol 38, No 4 ' 2010 WILEY-LISS, INC.

264 Diagnostic Cytopathology, Vol 38, No 4 ' 2010 WILEY-LISS, INC. Podoplanin Is a Useful Marker for Identifying Mesothelioma in Malignant Effusions Atef Hanna, M.D., Ph.D., 1 Yijun Pang, M.D., Ph.D., 1 Carlos W. M. Bedrossian, M.D., 2 Annika Dejmek, M.D., Ph.D., 3 and

More information

Diagnostic Pitfalls In Thoracic Tumors

Diagnostic Pitfalls In Thoracic Tumors 1376 Diagnostic Pitfalls In Thoracic Tumors Neda Kalhor, MD Cesar A. Moran, MD, FASCP WEEKEND OF PATHOLOGY AMERICAN SOCIETY FOR CLINICAL PATHOLOGY 33 W Monroe Ste 1600 Chicago, IL 60603 Program Content

More information

Pleural and Pericardial fluids a one year analysis

Pleural and Pericardial fluids a one year analysis Pleural and Pericardial fluids a one year analysis Dr Olafsdottir Dr J Williams Department of Cytology, Llandough Hospital Contents Background Standards Aims/Questions Investigation group Results Conclusions

More information

Metastatic Lobular Carcinoma of the Breast Presenting as a Frontal Scalp Mass and

Metastatic Lobular Carcinoma of the Breast Presenting as a Frontal Scalp Mass and Metastatic Lobular Carcinoma of the Breast Presenting as a Frontal Scalp Mass and Masquerading as Lymphoma: A Potential Pitfall in Aspiration Cytology Lauren Altman 1, Summer Student; Raptis George 2,

More information

Thoracic Mesothelium. Protocol applies to malignant thoracic mesothelioma. Procedures Cytology (No Accompanying Checklist) Incisional Biopsy Resection

Thoracic Mesothelium. Protocol applies to malignant thoracic mesothelioma. Procedures Cytology (No Accompanying Checklist) Incisional Biopsy Resection Thoracic Mesothelium Protocol applies to malignant thoracic mesothelioma. Protocol revision date: January 2004 Based on AJCC/UICC TNM, 6 th edition Procedures Cytology (No Accompanying Checklist) Incisional

More information

Male. Female. Death rates from lung cancer in USA

Male. Female. Death rates from lung cancer in USA Male Female Death rates from lung cancer in USA Smoking represents an interesting combination of an entrenched industry and a clearly drug-induced cancer Tobacco Use in the US, 1900-2000 5000 100 Per Capita

More information

YOUR LUNG CANCER PATHOLOGY REPORT

YOUR LUNG CANCER PATHOLOGY REPORT UNDERSTANDING YOUR LUNG CANCER PATHOLOGY REPORT 1-800-298-2436 LungCancerAlliance.org A GUIDE FOR THE PATIENT 1 CONTENTS What is a Pathology Report?...3 The Basics...4 Sections of a Pathology Report...7

More information

Role of immunohistochemistry

Role of immunohistochemistry Tumors of serous membranes of difficult diagnosis: Dr. Hector Battifora Role of immunohistochemistry Abstract: The most common differential diagnosis of tumors involving serosal surfaces is adenocarcinoma

More information

WORKPLACE SAFETY AND INSURANCE APPEALS TRIBUNAL DECISION NO. 1557/14

WORKPLACE SAFETY AND INSURANCE APPEALS TRIBUNAL DECISION NO. 1557/14 WORKPLACE SAFETY AND INSURANCE APPEALS TRIBUNAL DECISION NO. 1557/14 BEFORE: M. Crystal: Vice-Chair HEARING: August 20, 2014 at Toronto Written DATE OF DECISION: December 4, 2014 NEUTRAL CITATION: 2014

More information

The term undifferentiated tumor has been used in reference

The term undifferentiated tumor has been used in reference Undifferentiated Tumor True Identity by Immunohistochemistry Armita Bahrami, MD; Luan D. Truong, MD; Jae Y. Ro, MD, PhD Context. Undifferentiated tumor refers to a heterogeneous group of neoplasms with

More information

Emerging Subtypes in Renal Cancer. Donna E. Hansel, MD PhD Professor of Pathology, UC San Diego Division Chief, Anatomic Pathology dhansel@ucsd.

Emerging Subtypes in Renal Cancer. Donna E. Hansel, MD PhD Professor of Pathology, UC San Diego Division Chief, Anatomic Pathology dhansel@ucsd. Emerging Subtypes in Renal Cancer Donna E. Hansel, MD PhD Professor of Pathology, UC San Diego Division Chief, Anatomic Pathology dhansel@ucsd.edu Some General Comments Fuhrman nuclear grading clear cell

More information

Histolab Products AB. Eva Alströmer Jonas Falgén. Helsingborg 7-8/10 2010

Histolab Products AB. Eva Alströmer Jonas Falgén. Helsingborg 7-8/10 2010 Histolab Products AB Eva Alströmer Jonas Falgén Helsingborg 7-8/10 2010 Table 1 Formalin Fixation Times and Estrogen Receptor Staining With 25 Minutes Antigen Retrieval Pretreatment Formalin Q-Score Difference

More information

- Slide Seminar - Endocrine pathology in non-endocrine organs. Case 11. Stefano La Rosa, Gioacchino D Ambrosio, Fausto Sessa

- Slide Seminar - Endocrine pathology in non-endocrine organs. Case 11. Stefano La Rosa, Gioacchino D Ambrosio, Fausto Sessa - Slide Seminar - Endocrine pathology in non-endocrine organs Case 11 Stefano La Rosa, Gioacchino D Ambrosio, Fausto Sessa Dept. of Pathology, Multimedica, Milan, Italy Dept. of Surgical and Morphological

More information

Cytology of Effusion Fluids. Cytology of Effusion Fluids. Types of Effusion Fluids. Anatomy. Causes of Effusions. Sampling of Effusion Fluids

Cytology of Effusion Fluids. Cytology of Effusion Fluids. Types of Effusion Fluids. Anatomy. Causes of Effusions. Sampling of Effusion Fluids Cytology of Effusion Fluids John W. Wong, MD, FRCPC Sunnybrook Health Sciences Centre Assistant Professor, Laboratory Medicine and Pathobiology Faculty of Medicine, University of Toronto November 10, 2012

More information

Pathologist s Discussion of Plaintiffs Latest Theories

Pathologist s Discussion of Plaintiffs Latest Theories Pathologist s Discussion of Plaintiffs Latest Theories Mary Beth Beasley, MD Mt. Sinai Medical Center Annenberg Building 15th Floor Room 50 1468 Madison Avenue New York, NY 10029 (212) 241-5307 mbbeasleymd@yahoo.com

More information

Clinicopathological Study on Malignant Pleural Mesotheliomas

Clinicopathological Study on Malignant Pleural Mesotheliomas Table of Contents Clinicopathological Study on Malignant Pleural Mesotheliomas PL-4-03 Kenzo Hiroshima Kenzo Hiroshima 1, Akira Iyota 1, Kiyoshi Sibuya 1, Toshikazu Yusa 2, Takehiko Fujisawa 1 and Yukio

More information

"Advances in Surgical Pathology: New Entities, Emerging Concepts and New Perspectives on Old Problems"

Advances in Surgical Pathology: New Entities, Emerging Concepts and New Perspectives on Old Problems 123rd Semi-Annual Slide Seminar "Advances in Surgical Pathology: New Entities, Emerging Concepts and New Perspectives on Old Problems" Saul Suster, M.D. Chairman of Pathology Medical College of Wisconsin

More information

Diagnostic Slide Session Case Jennifer Ziskin MD, PhD, and Edward D Plowey MD, PhD Stanford University, Stanford, CA

Diagnostic Slide Session Case Jennifer Ziskin MD, PhD, and Edward D Plowey MD, PhD Stanford University, Stanford, CA Diagnostic Slide Session Case 2015-2 Jennifer Ziskin MD, PhD, and Edward D Plowey MD, PhD Stanford University, Stanford, CA Clinical History: 18 year old woman with right facial pain and hyperalgesia Past

More information

Lymphohistiocytoid Mesothelioma An Often Misdiagnosed Variant of Sarcomatoid Malignant Mesothelioma

Lymphohistiocytoid Mesothelioma An Often Misdiagnosed Variant of Sarcomatoid Malignant Mesothelioma Anatomic Pathology / LYMPHOHISTIOCYTOID MESOTHELIOMA Lymphohistiocytoid Mesothelioma An Often Misdiagnosed Variant of Sarcomatoid Malignant Mesothelioma Hasan S. Khalidi, MD, 1 L. Jeffrey Medeiros, MD,

More information

Original Article The immunohistochemical characterization of sarcomatoid malignant mesothelioma of the pleura

Original Article The immunohistochemical characterization of sarcomatoid malignant mesothelioma of the pleura Am J Cancer Res 2011;1(1):14-24 www.ajcr.us /ISSN:2156-6976/ajcr0000001 Original Article The immunohistochemical characterization of sarcomatoid malignant mesothelioma of the pleura Lucian R. Chirieac

More information

ASBESTOS EXPOSURE AND SARCOMATOID MALIGNANT PLEURAL MESOTHELIOMA Gorantla Sambasivarao 1, Namballa Usharani 2, Tupakula Suresh Babu 3

ASBESTOS EXPOSURE AND SARCOMATOID MALIGNANT PLEURAL MESOTHELIOMA Gorantla Sambasivarao 1, Namballa Usharani 2, Tupakula Suresh Babu 3 ASBESTOS EXPOSURE AND SARCOMATOID MALIGNANT PLEURAL MESOTHELIOMA Gorantla Sambasivarao 1, Namballa Usharani 2, Tupakula Suresh Babu 3 HOW TO CITE THIS ARTICLE: Gorantla Sambasivarao, Namballa Usharani,

More information

General Rules SEER Summary Stage 2000. Objectives. What is Staging? 5/8/2014

General Rules SEER Summary Stage 2000. Objectives. What is Staging? 5/8/2014 General Rules SEER Summary Stage 2000 Linda Mulvihill Public Health Advisor NCRA Annual Meeting May 2014 National Center for Chronic Disease Prevention and Health Promotion Division of Cancer Prevention

More information

Eugene J. Mark, M.D. Professor of Pathology Massachusetts General Hospital and Harvard Medical School Boston, Massachusetts, U.S.A.

Eugene J. Mark, M.D. Professor of Pathology Massachusetts General Hospital and Harvard Medical School Boston, Massachusetts, U.S.A. DIFFUSE MALIGNAT MESOTHELIOMAS: AN APPROACH TO DIAGNOSIS EMPHASIZING HEMATOXYLIN-EOSIN AND HISTORICAL ISSUES EMPHASIZING ASBESTOS Texas Society of Pathologists Dallas, Texas 14 January 2011 Eugene J. Mark,

More information

Immunohistochemical Expression of Osteopontin in Epithelioid Mesotheliomas and Reactive Mesothelial Proliferations

Immunohistochemical Expression of Osteopontin in Epithelioid Mesotheliomas and Reactive Mesothelial Proliferations natomic Pathology / OSTEOPONTIN IN MESOTHELIL PROLIFERTIONS Immunohistochemical Expression of Osteopontin in Epithelioid Mesotheliomas and Reactive Mesothelial Proliferations Dean-Yar Tigrani, MD, and

More information

FNA cytology of lymphomas: useless or useful? Edneia Tani

FNA cytology of lymphomas: useless or useful? Edneia Tani FNA cytology of lymphomas: useless or useful? Edneia Tani Karolinska University Hospital Stockholm Sweden FNAC LYMPH NODE First report: FNAC LYMPH NODE Pioneers Sixten Franzén Lopez Cardoso FNAC LYMPH

More information