page antibody Adipophilin (polyclonal) ALDH1A1 (44) c-myc (EP121) * Cadherin-17 (SP183) Cathepsin K (3F9)

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1 New IHC Antibodies

2 2 Table of Contents page antibody Adipophilin (polyclonal) ALDH1A1 (44) c-myc (EP121) * Cadherin-17 (SP183) Cathepsin K (3F9) Caveolin-1 (2297) CD13 (SP187) CD16 (SP175) CD123 (6H6) Cytokeratin (CAM 5.2) Cytokeratin 10 (EP97) * EGFR (SP84) EZH2 (11) FOXA1 (2F83) GATA3 (L50-823) GLUT3 (polyclonal) Glutamine Synthetase (GS-6) Heat Shock Protein 27 (G3.1) Langerin (12D6) MUC4 (8G7) MyoD1 (EP212) * Napsin A (MRQ-60) Nestin (10C2) Olig2 (211F1.1) Parvalbumin (2E11) S100A1 (EP184) * SALL4 (6E3) SOX-10 (polyclonal) Stathmin (SP49) Thyroid Peroxidase (EP159) * TIA-1 (EP243) * TLE1 (1F5) (ASR): Adenovirus (20/11 & 2/6) (ASR): Estrogen Receptor (EP1) * (ASR): Herpes Simplex Virus I (10A3) (ASR): Treponema pallidum (polyclonal)

3 New IHC Antibodies 1 Adipophilin (polyclonal) Adipophilin is useful in the identification of intracytoplasmic lipids in sebaceous neoplasms. Anti-adipophilin has high sensitivity and specificity for labeling sebaceous neoplasms, which helps distinguish them from basal cell carcinomas and squamous cell carcinomas. It is also helpful in the identification of more challenging cases of sebaceous carcinomas like small periocular biopsy specimens. 0.1 ml, concentrate A ml, concentrate A ml, concentrate A ml, predilute A ml, predilute A-18 5 Positive control slides S ALDH1A1 (44) ALDH1A1 aids in the identification of solitary fibrous tumors. It is primarily expressed in normal tissues of the epithelium of brain, eye, kidney, testis, and hematopoietic stem cells. ALDH1A1, when incorporated into an immunohistochemical panel, can aid in the differentiation between solitary fibrous tumor (SFT)/hemangiopericytoma (HPC) and meningioma, or synovial sarcoma. 0.1 ml, concentrate M ml, concentrate M ml, concentrate M ml, predilute M ml, predilute M-18 5 Positive control slides S c-myc (EP121) * Anti-c-Myc (EP121) * is a highly sensitive diagnostic marker for chromosome 8 translocations indicative of Burkitt lymphoma. This marker is often used in a panel with CD20, CD10, BCL6, BCL2, and Ki-67 for the differential diagnosis of highly aggressive Burkitt lymphoma. c-myc is also overexpressed in some breast carcinomas and prostate carcinomas. Unlike many other established clones of c-myc, which have a history of compatibility limitations with hematolymphoid neoplasms, Cell Marque s c-myc (EP121) * can be used as an aid on prostate, breast, and lymphomas! 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S Cadherin-17 (SP183) Cadherin-17 is expressed in many adenocarcinomas including colorectal, pancreatic, and gastric. Cadherin-17 is most commonly used in colorectal adenocarcinomas due to its diffuse and strong staining. In other adenocarcinomas, such as stomach, pancreas, and bile duct, cadherin-17 can be visualized as focal or scattered. Cadherin-17 can be complementary to E-Cadherin as they are both expressed in the intestinal mucosa. 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S Cathepsin K (3F9) Cathepsin K aids in the identification of translocation renal cell carcinoma. In recent literature, it has been reported that cathepsin K is highly specific for translocation RCC and can help distinguish it from different types of RCC and other carcinomas. It can also be expressed in alveolar soft part sarcomas. 0.1 ml, concentrate M ml, concentrate M ml, concentrate M ml, predilute M ml, predilute M-18 5 Positive control slides S

4 2 Caveolin-1 (2297) Caveolin-1 is useful in differentiating epithelioid mesothelioma (+) from lung adenocarcinoma ( ). This marker is a valuable addition to lung panels that include Napsin A, TTF-1, CEA, and Ber-EP4. Caveolin-1 is comparable to, and in some cases superior to other established markers for mesothelioma such as podoplanin, calretinin, HBME-1, and WT ml, concentrate M ml, concentrate M ml, concentrate M ml, predilute M ml, predilute M-18 5 Positive control slides S CD13 (SP187) CD13 s primary application is for acute myeloid leukemia (AML). Hematopathologists will find this antibody helpful in differentiating subtypes of AML. CD13 is expressed in myelomonocyctic cells in the late stage while CD33 stains the myeloblastic cells in the earlier stages of AML. These markers can be run together to help determine what stage of AML a patient is in. CD13 can also be used to differentiate myeloid sarcoma from mimicking carcinomas. It can be used in a panel with CD34, CD43, CD33, and MPO to help differentiate myeloid sarcoma in the late stage. 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S CD16 (SP175) CD16 is expressed in NK-cell lymphoma and stains specifically for NK leukemia in bone marrow. Anti-CD16 can be used in a panel with CD56, because CD16 can stain NK leukemia but does not stain NK/T-cell lymphoma, nasal type, which CD56 is known for. This antibody is also used in differentiating NK leukemia from other types of leukemia such as acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S CD123 (6H6) CD123 aids in the identification of blastic plasmacytoid dendritic cell neoplasm (BPDCN). CD123 is useful in differentiating BPDCN from myeloid sarcoma and large aggressive B cell lymphoma. When used in a panel with CD4, CD56, and TCL-1, CD123 can help distinguish between myeloid leukemia cutis and BPDCN. 0.1 ml, concentrate M ml, concentrate M ml, concentrate M ml, predilute M ml, predilute M-18 5 Positive control slides S Cytokeratin (CAM 5.2) Cytokeratin (CAM 5.2) is the most widely recognized low molecular weight keratin. CAM 5.2 is a marker that can be used in the identification of hepatocellular neoplasms, which are negative for Cytokeratin Cocktail (AE1/AE3), as well as for lymph node metastases of breast cancer and lung cancer. It can also be used to stain simple epithelia. 0.1 ml, concentrate M ml, concentrate M ml, concentrate M ml, predilute M ml, predilute M ml, predilute M-90 5 Positive control slides S

5 New IHC Antibodies 3 Cytokeratin 10 (EP97) * Cytokeratin 10 is used in the identification of squamous cell carcinomas. It is present in all suprabasal epithelial cells (stratified epithelium). Squamous cell carcinoma can arise from any type of stratified epithelium. Cytokeratin 10 can then help differentiate squamous cell carcinomas from non-squamous cell carcinomas. 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S EGFR (SP84) EGFR, also known as Epidermal Growth Factor Receptor, ErbB-1, and Her1, is used in the diagnosis of carcinomas. In a study conducted at Cell Marque and presented at USCAP 2014, EGFR was positive in 90% of triple negative breast carcinomas. 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S EZH2 (11) EZH2 is a marker used in the differential diagnosis of carcinomas. EZH2 is also helpful in differentiating follicular lymphoma (+) and mantle cell lymphoma (+) from marginal zone lymphoma ( ) and MALT lymphoma ( ). 0.1 ml, concentrate M ml, concentrate M ml, concentrate M ml, predilute M ml, predilute M-18 5 Positive control slides S FOXA1 (2F83) FOXA1 assists in the sub-classification of breast carcinomas. FOXA1 is a marker that can also be useful in the identification of luminal A subtype when used with ER, PR, and Her2/Neu. 0.1 ml, concentrate M ml, concentrate M ml, concentrate M ml, predilute M ml, predilute M-18 5 Positive control slides S GATA3 (L50-823) GATA3 expression is primarily seen in breast carcinoma. GATA3 is expressed in ALL lobular breast carcinomas and in a high percentage of invasive ductal carcinomas. GATA3 is negative in lung and thyroid carcinomas. It has been reported in literature that GATA3 expression is correlated with the status of ER, PR, and Her2/Neu in breast carcinoma. Another important application for GATA3 is in the identification of urothelial carcinomas. It is especially expressive in invasive and high-grade tumors, and is negative in prostate and renal cell carcinomas. Unlike other markers that have similar applications, GATA3 has a nuclear visualization. 0.1 ml, concentrate M ml, concentrate M ml, concentrate M ml, predilute M ml, predilute M-18 5 Positive control slides S

6 4 GLUT3 (polyclonal) GLUT3 is valuable in the identification of germ cell tumors and differentiating them from non-germ cell tumors and neoplasms. GLUT3 is commonly used in panels with SALL4 and Oct-4 (also known as Oct ¾). 0.1 ml, concentrate A ml, concentrate A ml, concentrate A ml, predilute A ml, predilute A-18 5 Positive control slides S Glutamine Synthetase (GS-6) Glutamine synthetase is a key marker in the identification of liver neoplasms, especially hepatocellular carcinoma. In HCC, glutamine synthetase is expressed strongly and diffusely in malignant hepatocytes. It can be used in a panel with glypican-3 and HSP70 to help distinguish between dysplastic and early malignant hepatocellular nodules appearing in cirrhosis. 0.1 ml, concentrate M ml, concentrate M ml, concentrate M ml, predilute M ml, predilute M-18 5 Positive control slides S Heat Shock Protein 27 (G3.1) Heat shock protein 27 (HSP27) is useful in the identification of high-grade dysplasia and cervical squamous cell carcinoma. A well-known cervical marker, p16, stains both high and low-grade dysplasia. It has been reported that HSP27 is expressed in a higher percentage of cervical squamous cell carcinomas than p16 (Tozawa-Ono A, et al. Human Cell 2012; 25:24 28). HSP27 is recommended as a complementary antibody to p16 for routine cervical dysplasia and cervical cancer testing. 0.1 ml, concentrate M ml, concentrate M ml, concentrate M ml, predilute M ml, predilute M-18 5 Positive control slides S Langerin (12D6) Langerin can aid in the diagnosis of Langerhans cell histiocytosis due to its high sensitivity and specificity for Langerhans cells. Evaluation of Langerin expression is valuable in circumstances where a diagnosis of Langerhans cell histiocytosis is suspected, but cannot be confirmed due to the lack of CD1a immunoreactivity. Langerin can also be utilized to help differentiate between Langerhans cell histiocytosis and other histiocytic proliferations. 0.1 ml, concentrate M ml, concentrate M ml, concentrate M ml, predilute M ml, predilute M-18 5 Positive control slides S MUC4 (8G7) Anti-MUC4 is the most valuable marker available for diagnosing low-grade fibromyxoid sarcoma. MUC4 immunohistochemistry is also a valuable tool for differentiating malignant pancreatic lesions (PDA and IPMN, which are both MUC4 positive) from benign pancreas (which is MUC4 negative). 0.1 ml, concentrate M ml, concentrate M ml, concentrate M ml, predilute M ml, predilute M-18 5 Positive control slides S

7 New IHC Antibodies 5 MyoD1 (EP212) * MyoD1 is highly sensitive and specific for rhabdomyosarcoma. It has a high sensitivity for both alveolar rhabdomyosarcoma and embryonal rhabdomyosarcoma. Anti-MyoD1 is often used with anti-myogenin due to their varying specificity and sensitivity for rhabdomyosarcoma. Unlike other established clones of MyoD1, which have a history of compatibility limitations with automation and detections, Cell Marque s MyoD1 (EP212) * is compatible with multiple automated platforms! 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S Napsin A (MRQ-60) Napsin A is commonly used to identify adenocarcinoma of the lung. It can be used in a panel with TTF 1, cytokeratin 5/14, and SOX 2 to differentiate lung adenocarcinoma from lung squamous cell carcinoma, an essential distinction to make when determining eligibility for various therapies. Napsin A is highly sensitive for lung adenocarcinoma including poorly differentiated lung adenocarcinoma, which can be missed by other markers. 0.1 ml, concentrate M ml, concentrate M ml, concentrate M ml, predilute M ml, predilute M-98 5 Positive control slides S Nestin (10C2) Nestin expression is correlated with advanced stages of melanoma. Like Cell Marque s SOX-10 (polyclonal), nestin exhibits positive staining in desmoplastic melanoma. Nestin is also considered an important marker for HMB-45 negative nodular melanoma as well as triple negative breast carcinoma of the basal phenotype. 0.1 ml, concentrate M ml, concentrate M ml, concentrate M ml, predilute M ml, predilute M-18 5 Positive control slides S Olig2 (211F1.1) Olig2 is involved in oligodendroglial specifications. Olig2 expression has been reported in most glial tumors, such as oligodendrogliomas and astrocytomas. Double staining with Olig2 and GFAP can be used in the characterization of astrocytomas, oligoastrocytomas and oligodendrogliomas. 0.1 ml, concentrate M ml, concentrate M ml, concentrate M ml, predilute M ml, predilute M-18 5 Positive control slides S Parvalbumin (2E11) Parvalbumin expression is correlated with chromophobe renal cell carcinoma. This antibody has been requested as a possible replacement for the colloidal iron stain on kidneys. Parvalbumin helps distinguish chromophobe renal cell carcinoma from clear cell RCC and papillary RCC. Oncocytomas show reactivity for parvalbumin, as well. 0.1 ml, concentrate M ml, concentrate M ml, concentrate M ml, predilute M ml, predilute M-18 5 Positive control slides S

8 6 S100A1 (EP184) * S100A1 is used in identifying renal oncocytoma. S100A1 differentiates renal oncocytoma from chromophobe renal cell carcinoma of the kidney. Combined with other IHC markers such as parvalbumin, CD117, Ksp-cadherin, and vimentin, S100A1 can be very useful in subtyping renal cell carcinoma. 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S SALL4 (6E3) SALL4 (6E3) is a valuable pan-germ cell tumor marker. It is seen to demonstrate high sensitivity for tumor cells in intratubular germ cell neoplasia, seminomas/ dysgerminomas, embroyonal carcinomas, and yolk sac tumors. Anti-SALL4 also stains teratomas and mononucleated trophoblastic cells in choriocarcinomas. 0.1 ml, concentrate M ml, concentrate M ml, concentrate M ml, predilute M ml, predilute M-18 5 Positive control slides S SOX-10 (polyclonal) Anti-SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. Its strong nuclear staining provides a cleaner signal than other antibodies like anti-s-100. The established pan melanoma markers, such as anti-hmb-45 and anti-mart-1/melan A, are known to have low expression in desmoplastic melanoma, which is one of SOX-10 s primary advantages. Anti-SOX-10 will not stain dendritic cells, macrophages, or fibroblasts when metastasis occurs. 0.1 ml, concentrate A ml, concentrate A ml, concentrate A ml, predilute A ml, predilute A-78 5 Positive control slides S Stathmin (SP49) Stathmin can be utilized to distinguish high-grade dysplasia (CIN II and CIN III) from low-grade dysplasia (CIN I). This distinction is very important as the current standard, p16, is unable to differentiate the different types of CIN since it stains all dysplasia equally. Stathmin is best used in a panel with p16, Ki-67, and Cytokeratin 17 for dysplasia and atypical immature metaplasia (AIM). 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S Thyroid Peroxidase (EP159) * Thyroid Peroxidase (TPO) is a useful marker for identifying thyroid carcinoma. When used in a panel with HBME-1, galectin-3 and cytokeratin 19, TPO can help with the identification of thyroid carcinoma of the papillary and follicular types. TPO is also useful in differentiating metastatic thyroid carcinoma from other carcinomas, especially lung adenocarcinoma. 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S

9 New IHC Antibodies 7 TIA-1 (EP243) * TIA-1 aids in the diagnosis of NK/T-cell lymphomas, hepatosplenic T-cell lymphomas, and anaplastic large cell lymphomas (ALCL). TIA-1 is often used with other cytotoxic granular markers, such as granzyme B and perforin, in T-cell lymphoma panels. 0.1 ml, concentrate R ml, concentrate R ml, concentrate R ml, predilute R ml, predilute R-18 5 Positive control slides S TLE1 (1F5) TLE1 is a marker that is highly sensitive for synovial sarcoma, a soft tissue sarcoma, which has historically been difficult to diagnose. It may be used in a panel to distinguish synovial sarcoma from other soft tissue malignancies. TLE1 has been shown to be more specific and sensitive for synovial sarcoma than established markers including BCL2, EMA, and cytokeratin cocktail. 0.1 ml, concentrate M ml, concentrate M ml, concentrate M ml, predilute M ml, predilute M-18 5 Positive control slides S

10 8 Analyte Specific Reagents (ASR) Adenovirus (20/11 & 2/6) Estrogen Receptor (EP1) * 0.1 ml, concentrate...212m-14 (ASR) 0.5 ml, concentrate...212m-15 (ASR) 1.0 ml, concentrate...212m-16 (ASR) 1.0 ml, predilute...212m-17 (ASR) 7.0 ml, predilute...212m-18 (ASR) 0.1 ml, concentrate...249r-24 (ASR) 0.5 ml, concentrate...249r-25 (ASR) 1.0 ml, concentrate...249r-26 (ASR) 1.0 ml, predilute...249r-27 (ASR) 7.0 ml, predilute...249r-28 (ASR) Herpes Simplex Virus I (10A3) Treponema pallidum (polyclonal) 0.1 ml, concentrate...361m-14 (ASR) 0.5 ml, concentrate...361m-15 (ASR) 1.0 ml, concentrate...361m-16 (ASR) 1.0 ml, predilute...361m-17 (ASR) 7.0 ml, predilute...361m-18 (ASR) 0.1 ml, concentrate...397a-14 (ASR) 0.5 ml, concentrate...397a-15 (ASR) 1.0 ml, concentrate...397a-16 (ASR) 1.0 ml, predilute...397a-17 (ASR) 7.0 ml, predilute...397a-18 (ASR) Powered by Technology * Rabbit Monoclonals Produced Using Technology from Epitomics, Inc. Under Patent No. 5,675,063 Rev. 0.3

11 25 25 ANTIBODIES ML THE LIST New Convenient Value Size! The number of immunohistochemistry stains has increased tremendously over the last few years. Customers have requested larger sizes, and now Cell Marque is pleased to offer 25 antibodies in a 25 ml size to meet your growing laboratory needs. Actin, Smooth Muscle (1A4)...#202M-90 BCL2 (124)...#226M-90 CD3 (polyclonal)...#103a-70 CD20 (L26)...#120M-80 CD45 (LCA) (2B11 & PD7/26)...#145M-90 Chromogranin A (LK2H10)...#238M-90 Cytokeratin (34betaE12)...#334M-80 Cytokeratin (CAM 5.2)...#452M-90 Cytokeratin 5 & 6 (D5 & 16B4)...#356M-10 Cytokeratin 7 (OV-TL 12/30)...#307M-90 Cytokeratin 8 & 18 (B22.1 & B23.1)...#818M-90 Cytokeratin 20 (Ks20.8)...#320M-10 Cytokeratin Cocktail (AE1 & AE3)...#313M-10 EMA (E29)...#247M-90 Ep-CAM (MOC-31)...#248M-10 Helicobacter pylori (polyclonal)...#215a-70 Kappa (L1C1)...#274M-90 Lambda (Lamb14)...#277M-90 MART-1 (Melan A) (M2-7C10)...#281M-90 Melanoma Cocktail (HMB-45 + A103 + T311)..#904H-00 P504s (13H4)...#504R-10 (ASR) S-100 (4C4.9)...#330M-10 Synaptophysin (polyclonal)...#336a-70 TTF-1 (8G7G3/1)...#343M-90 Vimentin (V9)...#347M-10 Are you ready to start saving? TOP 5 Want to Save Time? How about money? The availability of 25 ml sizes of select antibodies has become a huge hit! Laboratories all over the country are taking advantage of the savings. Here is a list of our top five best-selling 25 ml antibodies. Cytokeratin 7 (OV-TL 12/30)...#307M-90 Benefits: Resist rising laboratory costs with an economical bulk size Reduce shipping costs, fuel surcharges and other hidden fees Cut validation efforts with a larger volume, single-lot product Minimize your carbon footprint with fewer deliveries Extend shelf-life with 3 year expiration dates Cytokeratin 20 (Ks20.8)...#320M-10 Cytokeratin Cocktail (AE1 & AE3)...#313M-10 Helicobacter pylori (polyclonal)...#215a-70 P504s (13H4)...#504R-10 (ASR)

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