Anatomic Pathology Page 1 of 34

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1 Anatomic Pathology Page 1 of 34 Anatomic Pathology Major Category Code Headings Revised 9/2014 I Anatomic Pathology Management II General Pathology Principles III Breast IV Male genital V Cardiovascular VI Lymph Nodes and Spleen VII Bone Marrow VIII Head and Neck IX Alimentary Canal, Pancreas, Liver, Extrahepatic Biliary tree, Gall Bladder X Endocrine XI Female Genital, Placenta, Peritoneum XII Urinary XIII Respiratory, Pleura, Mediastinum XIV Central and Peripheral nervous system XV Soft Tissue and Bone XVI Skin XVII Molecular XVIII Forensic 33000

2 Anatomic Pathology Page 2 of 34 Anatomic Pathology CatCode I Anatomic Pathology Management A Management and professionalism and communication B Test Validation C Accreditation D Capital equipment acquisition E Billing and Compliance F Safety G Quality control, quality assurance, quality improvement H Basic statistics I Anatomic pathology information systems J Surgical pathology and autopsy reports K Slide review and consultation L Intraoperative consultation M Digital pathology and telepathology N Gross techniques in surgical and autopsy pathology O Special techniques and tissue preparation Special stains Enzyme histochemistry Immunohistochemistry Electron microscopy Flow cytometry Cytogenetics P Medical-legal II General Pathology Principles A Cell injury B Inflammation and Repair C Genetic disorders D Immunopathology E Neoplasia F Infectious disease G Nutritional disorders H Environmental Pathology III Breast A Techniques Frozen section Needle biopsy Open biopsy, lumpectomy Mastectomy Sentinel lymph node biopsy Imaging and localization Ancillary studies (ER, PR, Her2/neu) Fixation Other immunohistochemistry B Normal breast Physiological changes C Benign breast disease 30053

3 Anatomic Pathology Page 3 of 34 1 Apocrine metaplasia Benign cysts Adenosis, including sclerosing adenosis, tubular adenosis, 3 microglandular adenosis, columnar cell alteration Radial scar Epithelial hyperplasia a Usual ductal hyperplasia b Atypical ductal hyperplasia c Flat epithelial atypia d Atypical lobular hyperplasia D Papillary lesions Intraductal papilloma Juvenile papillomatosis Intracystic papillary carcinoma E Ductal carcinoma in situ F Lobular carcinoma in situ G Infiltrating carcinoma Infiltrating ductal carcinoma, NOS a Grading b Prognostic factors Infiltrating lobular carcinoma Tubular carcinoma Mucinous carcinoma Infiltrating cribriform carcinoma Medullary carcinoma Invasive micropapillary carcinoma Adenoid cystic carcinoma Secretory carcinoma Apocrine carcinoma Metaplastic carcinoma Basal-like carcinoma Inflammatory carcinoma Axillary lymph nodes Other infiltrating carcinoma H Nipple Nipple adenoma Syringomatous adenoma Paget disease of the nipple I Male breast carcinoma J Therapy induced changes K Metastatic carcinoma involving breast (within breast from another site) L Mixed epithelial and stromal tumors Fibroadenoma Juvenile fibroadenoma Tubular adenoma Lactating adenoma 30105

4 Anatomic Pathology Page 4 of 34 5 Phyllodes tumor M Mesenchymal tumors breast Benign tumors (lipoma, hemangioma, leiomyoma, other) Angiosarcoma Post mastectomy lymphangiosarcoma Radiation induced sarcoma Other mesenchymal tumors-breast N Hematopoietic lesions Lymphoma Rosai-Dorfman O Other benign tumors Ductal adenoma Pleomorphic adenoma Adenomyoepithelioma Myofibroblastoma P Inflammatory lesions Fat necrosis Granulomatous mastitis Duct ectasia Silicone reaction Diabetic mastopathy Q Miscellaneous breast Gynecomastia Juvenile hypertrophy Hamartoma Pseudoangiomatous stromal hyperplasia Mucocele-like lesions Galactocele Collagenous spherulosis IV Male genital A Prostate and Seminal Vesicles Normal Benign Prostatic hyperplasia Inflammatory lesions a Bacterial prostatitis b Fungal prostatitis c Tuberculous prostatitis d Granulomatous prostatitis e Post-biopsy granulomas f Malacoplakia Benign non-neoplastic conditions a Amyloid b Calculi c Cysts d Melanocytic lesions e Miscellaneous benign non-neoplastic conditions 30168

5 Anatomic Pathology Page 5 of 34 5 Adenocarcinoma of Prostate, acinar (usual) type a Gleason grading b Mimickers of prostate cancer i Adenosis ii Atrophy iii Postatrophic hyperplasia iv Normal seminal vesicle v Cowper gland vi Xathoma vii Nephrogenic adenoma (metaplasia) viii Veromontanum hyperplasia ix Paraganglion x Clear cell cribriform hyperplasia c Immunohistochemistry d Prostatic intraepithelial neoplasia e Intraductal carcinoma f Prostatectomy specimens i Extraprostatic extension ii Seminal vesicle invasion iii Lymph node metastasis iv Margins v Prostatectomy Gleason grading vi Tumor volume g Therapy effects i Radiation ii Anti-androgen h Variants of Prostatic adenocarcinoma i Mucinous adenocarcinoma ii Neuroendocrine carcinoma iii Prostatic duct adenocarcinoma iv Basal cell carcinoma i Miscellaneous disorders of Prostate i Mesenchymal tumors prostate ii Basal cell hyperplasia and carcinoma iii Prostatic urethral polyps iv Lymphoma/leukemia j Seminal Vesicles B Testis Non-neoplastic a Normal anatomy and embryology b Cryptorchidism c Torsion/infarction d Varicocele e Infertility i Hypospermatogenesis ii Maturation arrest iii Germinal cell aplasia 30227

6 Anatomic Pathology Page 6 of 34 iv Karyotypic abnormalities v Duct obstruction, vasitis nodosum f Drug effects on testis g Radiation effects on testis h Testicular cysts i Epididymis j Infectious disease k Intersex syndromes Testicular and Paratesticular Tumors a Germ cell tumors i Intratubular germ cell neoplasia ii Seminoma iii Spermatocytic seminoma iv Embryonal carcinoma v Yolk sac tumor vi Teratoma vii Epidermoid cyst and dermoid cyst viii Carcinoid ix Mixed germ cell tumor x Choriocarcinoma xi Chemotherapy effects xii Other germ cell tumors b Sex cord-stromal tumors i Leydig cell tumor ii Sertoli cell tumor iii Granulosa cell tumor iv Fibroma c Mixed germ cell-sex cord-stromal tumors i Gonadoblastoma d Hematopoietic tumors i Lymphoma ii Leukemia iii Plasmacytoma e Mesenchymal tumors testis f Metastatic tumors testis g Rete testis tumors h Tumors of tunica albuginea and mesothelium i Epididymal tumors j Spermatic cord/paratesticular tumors C Penis Normal anatomy Infections Miscellaneous penis a Phimosis b Lichen sclerosus Neoplasms 30288

7 Anatomic Pathology Page 7 of 34 a Squamous hyperplasia b Penile intraepithelial neoplasia c Bowenoid papulosis d Squamous cell carcinoma e Paget Disease V Cardiovascular A Normal anatomy B Ischemic heart disease Myocardial infarction C Hypertensive heart disease D Congenital heart disease E Myocardial diseases Primary cardiomyopathy a Dilated cardiomyopathy b Hypertrophic cardiomyopathy c Restrictive cardiomyopathy d Arrythmogenic right ventricular cardiomyopathy/dysplasia Secondary cardiomyopathy a Amyloidosis b Glycogen storage disease c Fabry disease d Hemochromatosis e Pheochromocytoma f Anthracycline cardiotoxicity Inflammatory cardiomyopathy (myocarditis) a Lymphocytic myocarditis b Infectious myocarditis c Drug related myocarditis d Toxic myocarditis e Rheumatic fever f Collagen vascular disease g Peripartum myocarditis h Sarcoidosis i Giant cell myocarditis F Cardiac transplantation Cardiac allograft rejection G Cardiac tumors Rhabdomyoma Cardiac myxoma Angiosarcoma Other cardiac tumors H Cardiac valvular lesions Aortic valvular lesions Mitral valve lesions Tricuspid and pulmonary valvular disease 30358

8 Anatomic Pathology Page 8 of 34 4 Infective endocarditis Noninfective endocarditis I Pericardial diseases J Diseases of blood vessels Hereditary diseases of blood vessels a Marfan syndrome b Non Marfan familial aortic dissection c Ehlers-Danlos syndrome d Other hereditary diseases of blood vessels Fibromuscular dysplasia Peripheral aneurysms and dissections Medial calcification (Monckeberg) Atherosclerosis Vasculitis a Takayasu disease b Giant cell arteritis c Polyarteritis nodosa d Kawasaki disease e Buerger disease f Wegener's granulomatosis g Churg-Strauss angiitis h Microscopic polyangiitis i Immune complex mediated small vessel vasculitis j Other vasculitis Vascular thrombosis Tumors of great vessels and muscular arteries a Carotid body paraganglioma b Aorticopulmonary paraganglioma c Other tumors of great vessels and muscular arteries VI Lymph Nodes and Spleen A Diseases of the lymph nodes Reactive lymphadenopathy a Toxoplasmosis b Cat-scratch disease c Other infectious lesions of lymph nodes d Rheumatoid related lymphadenopathy e Kikuchi-Fujimoto disease f Kimura disease g Castleman disease h Progressive transformation of germinal centers i Post transplant lymphoproliferative disorder j Hemophagocytic lymphohistiocytosis k Dermatopathic lymphadenopathy l Rosai-Dorfman disease m Drug reaction (such as Dilantin) n Sarcoidosis 30416

9 Anatomic Pathology Page 9 of 34 o Infectious mononucleosis p HIV lymphadenopathy q Other reactive lymphadenopathy Hodgkin lymphoma a Nodular lymphocyte predominant b Classical B lymphoblastic leukemia/lymphoma T lymphoblastic lymphoma/leukemia Mature B-cell neoplasms a Chronic lymphocytic leukemia/small lymphocytic lymphoma b Splenic marginal zone lymphoma c Nodal marginal zone lymphoma d Extranodal marginal zone lymphoma (MALT lymphoma) e Mantle cell lymphoma f Follicular lymphoma g Lymphoplasmacytic lymphoma h Hairy cell leukemia i Diffuse large B cell lymphoma and variants j Burkitt lymphoma k Other mature B-cell neoplasms Mature T cell and NK cell neoplasms a Peripheral T-cell lymphoma, NOS b Angioimmunoblastic T-cell lymphoma c Anaplastic large cell lymphoma d Mycosis fungoides and Sezary syndrome e Adult T-cell leukemia/lymphoma f Hepatosplenic T-cell lymphoma g NK cell lymphoma h Other mature T-cell and NK cell neoplasms Histiocytic neoplasms a Langerhans cell histiocytosis b Dendritic cell tumors c Other histiocytic neoplasms Metastatic neoplasms lymph nodes Leukemic involvement of lymph nodes Leukemic involvement of soft tissues Other diseases of the lymph nodes B Disorders of spleen Non-neoplastic conditions a Follicular hyperplasia b Immune thrombocytopenic purpura c Congestion d Infections e Lipid histiocytoses f Other non-neoplastic conditions disorders of spleen 30470

10 Anatomic Pathology Page 10 of 34 2 Neoplastic conditions a B-cell lymphoma b T-cell lymphoma c Hodgkin lymphoma d Leukemias/myeloproliferative disorders i Myeloid metaplasia ii Chronic myelogenous leukemia iii Hairy cell leukemia iv Other leukemias/myeloproliferative disorders e Non-hematopoietic disorders i Vascular tumors f Other neoplastic conditions disorders of spleen VII Bone Marrow A Inflammatory disorders of bone marrow B Acute myeloid leukemia C Precursor B acute lymphoblastic leukemia D Precursor T acute lymphoblastic leukemia E Myelodysplastic syndrome F Chronic myeloproliferative diseases G Mastocytosis H Non-Hodgkin lymphoma I Hairy cell leukemia J Hodgkin lymphoma K Plasma cell neoplasms L Histiocytic proliferations Storage diseases Langerhans cell histiocytosis Infection associated hemophagocytic syndrome Other histiocytic proliferations M Metastatic tumors bone marrow N Platelet disorders O Other bone marrow VIII Head and Neck A Jaws and Oral Cavity Oral cavity, non-neoplastic a Gingivitis b Lichen planus c Pyogenic granuloma d Peripheral giant cell granuloma e Infection f Other oral cavity, non-neoplastic Oral cavity, neoplastic a Oral papilloma b Squamous dysplasia c Squamous cell carcinoma d Granular cell tumor e Other oral cavity, neoplastic 30526

11 Anatomic Pathology Page 11 of 34 3 Jaws a Odontogenic cysts b Odontogenic neoplasms c Fibrous dysplasia d Central giant cell granuloma e Other jaws B Salivary glands Non-neoplastic processes a Mucocele and ranula b Necrotizing sialometaplasia c Lymphoepithelial cyst d Sjögren syndrome and minor salivary gland biopsy Neoplastic conditions a Pleomorphic adenoma (including myoepithelioma) b Warthin tumor c Basal cell adenoma (and basal cell adenocarcinoma) d Canalicular adenoma e Oncocytoma and oncocytic carcinoma f Sebaceous adenoma and lymph adenoma g Adenoid cystic carcinoma h Mucoepidermoid carcinoma i Acinic cell adenocarcinoma j Polymorphous low-grade adenocarcinoma k Salivary duct carcinoma l Epithelial-myoepithelial carcinoma m Benign lymphoepithelial lesion n Lymphoepithelioma-like undifferentiated carcinoma o Lymphoma p Other neoplastic salivary glands C Nose, paranasal sinuses, and nasopharynx Normal anatomy Infections Wegener's granulomatosis Nasal polyps Squamous and schneiderian papillomas Respiratory epithelial adenomatoid hamartoma Squamous cell carcinoma, including lymphoepithelioma of 7 nasopharynx Adenocarcinoma Neural, neuroectodermal, and neuroendocrine tumors a Olfactory neuroblastoma b Small cell undifferentiated carcinoma c Sinonasal undifferentiated carcinoma d Melanoma e Paraganglioma Pituitary adenoma 30579

12 Anatomic Pathology Page 12 of Craniopharyngioma Glial heterotopia Meningioma Lymphoma, including NK/T cell lymphoma Plasmacytoma Angiofibroma Lobular capillary hemangioma (pyogenic granuloma) Mesenchymal tumors nose, paranasal sinuses, and 18 nasopharynx Osseous tumors Other nose, paranasal sinuses, and nasopharynx D Larynx Normal anatomy Non-neoplastic a Contact ulcer b Vocal cord polyp and nodule c Cysts d Infection Neoplastic a Squamous papilloma b Squamous dysplasia c Squamous cell carcinoma d Salivary gland tumors e Neural, neuroendocrine and neuroectodermal tumors i Neuroendocrine carcinoma ii Paraganglioma iii Nerve sheath tumors iv Melanoma f Mesenchymal tumors larynx g Hematolymphoid tumors h Other neoplastic larynx E Ear and temporal bone Normal anatomy Non-neoplastic a Branchial cleft anomalies b Infections c Otic (aural) polyp d Keloid e Chondrodermatitis nodularis f Auricular pseudocyst g Angiolymphoid hyperplasia with eosinophilia h Kimura disease i Cholesteatoma j Other non-neoplastic ear and temporal bone Neoplastic a Ceruminal gland adenoma 30634

13 Anatomic Pathology Page 13 of 34 b Squamous cell carcinoma c Middle ear adenoma d Paraganglioma, jugulotympanic e Schwannoma f Endolymphatic sac papillary tumor g Other neoplastic ear and temporal bone F Eye and Ocular Adnexa Normal anatomy Globe Cornea Conjunctiva Eyelids Lens Retina Iris, ciliary body and choroid Orbit Optic nerve Lacrimal gland Other eye and ocular adnexa IX Alimentary Canal, Pancreas, Liver, Extrahepatic Biliary tree, Gall Bladder A GI tract Esophagus a Normal anatomy b Esophagitis i Infectious ii Reflux iii Eosinophilic esophagitis iv Sloughing esophagitis v Other esophagitis c Barrett esophagus i Dysplasia d Neuromuscular disease e Squamous papilloma f Mesenchymal tumors esophagus g Squamous dysplasia h Squamous cell carcinoma i Adenocarcinoma j Other esophagus Stomach a Normal anatomy b Gastritis i Hemorrhagic erosive gastritis ii Suppurative gastritis iii Helicobacter gastritis iv Multifocal atrophic gastritis v Autoimmune gastritis vi Eosinophilic gastritis 30691

14 Anatomic Pathology Page 14 of 34 vii Lymphocytic gastritis viii Carditis ix Reactive gastropathy x Other gastritis c Polyps i Hamartoma ii Fundic gland polyp iii Hyperplastic polyp iv Adenoma v Inflammatory fibroid polyp vi Other polyps d Gastric ulcer e Zollinger-Ellison Syndrome f Menetrier Disease g Gastric dysplasia h Adenocarcinoma i Neuroendocrine tumors j Lymphoma k Mesenchymal tumors stomach i Gastrointestinal stromal tumors ii Other mesenchymal tumors stomach l Other stomach Small intestine a Normal anatomy b Non-neoplastic i Infections ii Development lesions aa Small intestinal duplication cyst ab Meckel diverticulum ac Gastric heterotopia ad Ectopic pancreas iii Celiac Disease and tropical sprue iv Whipple disease v Pouchitis vi Necrotizing enterocolitis vii Peptic duodenitis/ulcer viii Hamartomatous polyp ix Autoimmune enteropathy x Crohn disease xi Other non-neoplastic small intestine c Neoplastic i Adenoma ii Adenocarcinoma iii Neuroendocrine tumors iv Lymphoma v Other neoplastic small intestine Appendix 30749

15 Anatomic Pathology Page 15 of 34 a Appendicitis b Enterobius vermicularis c Polyps d Mucinous cystic neoplasms e Adenocarcinoma f Pseudomyxoma peritonei g Neuroendocrine tumors i Goblet cell carcinoid/mixed adenocarcinoma/carcinoid h Other appendix Colorectal a Normal anatomy b Congenital/development i Hirschsprung disease ii Colonic duplications/cysts c Motility disorders d Diverticular disease e Melanosis coli f Idiopathic inflammatory bowel disease i Ulcerative colitis ii Crohn disease iii Dysplasia and IBD-related adenocarcinoma g Lymphocytic colitis h Collagenous colitis i Ischemic colitis j Diversion colitis k Diverticular disease related colitis l Acute infectious colitis (acute self-limited colitis) m Focal active colitis n Pseudomembranous colitis (Clostridium difficile colitis) o Enterohemorrhagic colitis (E. Coli) p Amebic colitis q Other infectious colitis (viral, fungal, parasitic) r Mucosal prolapse/solitary rectal ulcer s Pneumatosis coli t Polyps i Hyperplastic polyp ii Tubular (and tubulovillous) adenoma Adenoma with invasive aa adenocarcinoma iii Sessile (and traditional) serrated adenoma iv Hamartomatous polyp u Adenocarcinoma i Familial colorectal cancer syndromes aa Familial adenomatous polyposis 30800

16 Anatomic Pathology Page 16 of 34 ab Lynch syndrome Other familial colorectal cancer ac syndromes v Neuroendocrine tumors w Mesenchymal tumors colorectal x Other colorectal Anal canal a Hemorrhoids b Tailgut cyst c Condyloma d Anal intraepithelial neoplasia e Squamous cell carcinoma f Paget Disease g Anal duct carcinoma h Other anal canal B Liver Normal anatomy Development disease Metabolic disease a Hemochromatosis b Wilson disease c Alpha 1 antitrypsin deficiency d Other metabolic disease Biliary tract disease a Large duct obstruction b Primary sclerosing cholangitis c Primary biliary cirrhosis Drug induced liver disease Viral hepatitis (hepatitis A, B, C) EBV, CMV and Herpes hepatitis Bacterial, fungal and parasitic liver disease Autoimmune hepatitis a Overlap syndromes Steatohepatitis a Alcoholic liver disease b NASH Vascular disorders of liver Cirrhosis Transplantation a GVHD Benign infectious cysts a Amebic abscess b Pyogenic abscess c Echinococcus abscess Bile duct hamartoma (Von Meyenburg complex) Solitary (simple) cyst Polycystic liver disease and congenital hepatic fibrosis 30874

17 Anatomic Pathology Page 17 of Neoplastic cysts a Biliary cystadenoma and cystadenocarcinoma b Teratoma c Mesenchymal hamartoma Hepatocellular adenoma Focal nodular hyperplasia Nodular regenerative hyperplasia Macroregenerative nodules in cirrhosis Hepatocellular carcinoma a Fibrolamellar hepatocellular carcinoma Hepatoblastoma Cholangiocarcinoma Neuroendocrine tumors Mesenchymal tumors liver a Hemangioma b Infantile hemangioendothelioma c Angiomyolipoma d Epithelioid hemangioendothelioma e Other mesenchymal tumors liver Lymphoma/leukemia Metastatic carcinoma liver Massive hepatic necrosis Other liver C Pancreas Normal anatomy Non-neoplastic a Developmental anomalies b Inflammatory conditions i Acute and chronic pancreatitis ii Autoimmune pancreatitis iii Pseudocyst Neoplastic a Serous cystadenoma b Mucinous cystic neoplasm c Intraductal papillary mucinous neoplasm d Pancreatic intraepithelial neoplasia (PanIN) e Ductal adenocarcinoma f Acinar cell carcinoma g Pancreatoblastoma h Solid pseudopapillary neoplasm i Pancreatic neuroendocrine tumors j Other neoplastic pancreas D Gallbladder, extrahepatic biliary tree Normal anatomy Developmental and congenital anomalies Cholecystitis and cholelithiasis Sclerosing cholangitis 30934

18 Anatomic Pathology Page 18 of 34 5 Gallbladder polyps and adenomas Gallbladder dysplasia Adenocarcinoma of gallbladder Adenocarcinoma of extrahepatic bile ducts Neuroendocrine tumors Other gallbladder, extrahepatic biliary tree X Endocrine A Multiple endocrine neoplasia B Pituitary and sella Normal anatomy Pituitary adenomas Invasive and atypical adenomas Pituitary oncocytoma Pituitary cysts Craniopharyngioma Hypophysitis Other pituitary and sella C Thyroid Normal anatomy Non-neoplastic a Thyroiditis b Graves disease c Pigmentary alteration d Nodular goiter e Other non-neoplastic thyroid Neoplastic a Follicular adenoma b Papillary carcinoma c Follicular carcinoma d Hurthle cell lesions e Medullary carcinoma f Poorly differentiated carcinoma (insular carcinoma) g Anaplastic carcinoma h Lymphoma i Other neoplastic thyroid D Parathyroid Normal anatomy Parathyroid adenoma Parathyroid hyperplasia Parathyroid carcinoma Other parathyroid E Adrenal Normal anatomy Congenital/development abnormalities Adrenal cytomegaly Adrenal hypofunction a Autoimmune adrenalitis 31099

19 Anatomic Pathology Page 19 of 34 b Infection c Hemorrhage Adrenal cysts Myelolipoma Adrenal hyperfunction a Adrenocortical hyperplasia Adrenocortical adenoma Adrenocortical carcinoma Metastatic carcinoma adrenal Neuroblastoma Pheochromocytoma Other adrenal F Paraganglioma XI Female Genital, Placenta, Peritoneum A Gestational Trophoblastic Disease Hydatidiform mole Exaggerated placental site Choriocarcinoma Placental site trophoblastic tumor Epithelioid trophoblastic tumor B Placenta Normal anatomy Umbilical cord abnormalities a Funisitis b Blood vessel abnormalities Fetal membrane abnormalities a Amnion nodosum b Chorioamnionitis c Other fetal membrane abnormalities Placental disc abnormalities a Abruption b Infarcts c Intervillous thrombi d Maternal floor infarction e Placenta accreta f Villitis and intervillositis Eclampsia and atherosis Fetal thrombotic vasculopathy (hemorrhagic endovasculitis) Chorangioma Multiple pregnancy Other placenta, including products of conception C Vulva Normal anatomy Congenital abnormalities Cysts Infections (other than condyloma) 31162

20 Anatomic Pathology Page 20 of 34 5 Lichen sclerosus Aggressive angiomyxoma Angiomyofibroblastoma Cellular angiofibroma Hidradenoma papilliferum Vulvar intraepithelial neoplasia, including condyloma Squamous cell carcinoma Melanoma Paget disease Other vulva D Vagina Normal anatomy Congenital anomalies Adenosis Infections Stromal polyp Vaginal intraepithelial neoplasia Squamous cell carcinoma Clear cell carcinoma Other vagina E Cervix Normal anatomy Infections Squamous intraepithelial lesions Squamous cell carcinoma Polyps Nabothian cyst and tunnel clusters Microglandular adenosis Mesonephric rests and hyperplasia Endometriosis Tubal metaplasia Adenocarcinoma in situ Endocervical adenocarcinoma Mesonephric adenocarcinoma Adenoid basal carcinoma Adenoid cystic carcinoma Mesenchymal tumors cervix Other cervix F Uterine Corpus Endometrium, epithelial, non-neoplastic a Normal endometrial patterns b Arias-Stella reaction c Placental site nodule d Endometritis e Iatrogenic patterns f Atrophy g Disordered proliferative 31215

21 Anatomic Pathology Page 21 of 34 h Hyperplasia i Metaplasia j Endometrial polyp Endometrium, epithelial, neoplastic a Endometrioid adenocarcinoma b Serous carcinoma c Clear cell carcinoma Mixed epithelial/stromal tumors a Adenomyoma b Atypical polypoid adenomyoma c Adenofibroma d Adenosarcoma e Carcinosarcoma Endometrial stromal tumors a Stromal nodule b Low grade endometrial stromal sarcoma c Undifferentiated endometrial stromal sarcoma d Uterine tumors with sex cord elements Myometrium, non neoplastic a Adenomyosis Myometrial, neoplastic a Smooth muscle tumors b Other myometrial, neoplastic Miscellaneous tumors of uterus a Adenomatoid tumor b Lymphoma c PEComa d Other miscellaneous tumors of uterus G Ovaries Normal anatomy Non-neoplastic a Infections b Endosalpingiosis c Follicular cysts d Hyperreactio luteinalis e Polycystic ovaries f Stromal hyperplasia and hyperthecosis g Massive edema h Pregnancy luteoma i Other non-neoplastic ovaries Surface epithelial-stromal tumors a Serous tumors b Mucinous tumors c Endometrioid tumors d Clear cell tumors e Transitional cell tumors f Other surface epithelial-stromal tumors 31280

22 Anatomic Pathology Page 22 of 34 4 Sex-cord-stromal tumors a Granulosa cell tumors b Fibrothecoma c Sclerosing stromal tumors d Sertoli and Sertoli-Leydig tumors e Gynandroblastoma f Steroid cell tumors g Sex-cord tumor with annular tubules h Other sex-cord-stromal tumors Germ cell tumors a Dysgerminoma b Yolk sac tumor c Embryonal cell carcinoma d Choriocarcinoma e Teratoma f Gonadoblastoma g Other germ cell tumors Miscellaneous ovarian tumors a Mesenchymal tumors ovary b Lymphoma/leukemia c Small cell carcinoma d Tumor of probably wolffian origin e Metastatic tumors ovary f Other miscellaneous ovarian tumors H Fallopian tube and broad ligament Non-neoplastic a Inflammatory/infectious b Salpingitis isthmica nodosa c Ectopic pregnancy d Endometriosis e Cysts f Walthard cell rests g Other non-neoplastic fallopian tube and broad ligament Neoplastic a Adenomatoid tumor b BRCA associated lesions c Adenocarcinoma d Female adnexal tumor of probably wolffian origin e Other neoplastic fallopian tube and broad ligament I Peritoneum Non-neoplastic a Inflammatory/infectious b Mesothelial hyperplasia c Peritoneal inclusion cyst d Endometriosis e Endosalpingiosis 31336

23 Anatomic Pathology Page 23 of 34 f Other non-neoplastic peritoneum Neoplastic a Solitary fibrous tumor b Well differentiated papillary mesothelioma c Mesothelioma d Desmoplastic small round cell tumor e Inflammatory myofibroblastic tumor f Peritoneal leiomyomatosis g Other neoplastic peritoneum XII Urinary A Kidney Development/congenital lesions Medical renal disease a Tissue processing b Proliferative glomerulonephritides Acute diffuse intracapillary proliferative i glomerulonephritis (post infectious/poststreptococcal GN) ii Membranoproliferative glomerulonephritis iii Diffuse extracapillary proliferative (crescentic) glomerulonephritis iv Other proliferative glomerulonephritides Non-glomerulonephritic glomerulonephropathies c (glomerular capillary wall lesions leading to nephrotic syndrome) i Minimal change nephrotic syndrome ii Focal segmental glomerular sclerosis iii Membranous glomerulonephritis iv Diabetic nephropathy v Other non-glomerulonephritic glomerulonephropathies d Glomerular diseases associated with isolated hematuria i IgA nephropathy ii Henoch-Schonlein purpura iii Thin basement membrane disease iv Alport syndrome v Other glomerular diseases e Diseases associated with acellular closure of glomerular capillaries i Thrombotic microangiopathy ii Cryoglobulinemic glomerulonephritis iii Amyloidosis iv Fibrillary glomerulonephritis v Other diseases-acellular closure f Lupus nephropathies g Monoclonal gammopathy associated renal disease 31387

24 Anatomic Pathology Page 24 of 34 h Tubulointerstitial disease i Acute tubular necrosis ii Pyelonephritis iii Interstitial nephritis iv Other tubulointerstitial disease i Vascular lesions i Arterial and arteriolar nephrosclerosis ii Renal artery stenosis iii Renal atheroembolic disease iv Vasculitis j End Stage Renal disease k Renal transplantation l Other medical renal disease Renal tumors a Adult i Clear-cell renal cell carcinoma ii Papillary renal cell carcinoma iii Chromophobe renal cell carcinoma iv Oncocytoma v Collecting duct carcinoma vi Medullary carcinoma vii Mucinous tubular and spindle cell carcinoma viii Translocation related renal cell carcinoma ix Mixed epithelial and stromal tumor x Cystic nephroma xi Neuroendocrine tumors xii Metanephric adenoma xiii Adult Wilms xiv Angiomyolipoma xv Mesenchymal tumors renal xvi Lymphoma xvii Other adult renal tumors b Pediatric i Wilms tumor ii Congenital mesoblastic nephroma iii Clear cell sarcoma iv Rhabdoid tumor v Translocation renal cell carcinomas vi Other pediatric renal tumors B Urothelial tract Normal anatomy Non-neoplastic a Inflammatory b BCG effects c Radiation changes d Diverticuli e Cystitis glandularis 31447

25 Anatomic Pathology Page 25 of 34 f Nephrogenic metaplasia g Urethral polyp h Other non-neoplastic urothelial tract Neoplastic a Urothelial papilloma b Papillary urothelial neoplasm of low malignant potential c Papillary urothelial carcinoma d Urothelial dysplasia e Urothelial carcinoma-in-situ f Invasive urothelial carcinoma and variants g Squamous cell carcinoma h Villous adenoma i Adenocarcinoma j Urachal carcinoma k Neuroendocrine carcinoma l Mesenchymal lesions urothelial tract m Other neoplastic urothelial tract XIII Respiratory, Pleura, Mediastinum A Lung Normal anatomy Non-neoplastic a Congenital cystic lesions b Emphysema c Infections d Interstitial inflammatory disease i Usual interstitial pneumonia ii Desquamative interstitial pneumonia iii Nonspecific interstitial pneumonia e Diffuse alveolar damage f Hypersensitivity pneumonitis g Pulmonary fibrosis/honeycomb lung h Eosinophilic pneumonia i Allergic bronchopulmonary aspergillosis j Bronchocentric granulomatosis k Bronchiolitis obliterans with organizing pneumonia (cryptogenic organizing pneumonia) l Small airway disease i Respiratory bronchiolitis ii Bronchiolocentric interstitial lung disease iii Constrictive bronchiolitis m Eosinophilic granuloma (Langerhans cell granulomatosis) n Lymphocytic infiltrations i Lymphoid interstitial pneumonia ii Follicular bronchitis o Inflammatory myofibroblastic tumor 31502

26 Anatomic Pathology Page 26 of 34 p Wegener granulomatosis q Sarcoid r Churg-Strauss s Polyarteritis nodosa t Pulmonary hypertension u Pulmonary alveolar proteinosis v Amyloidosis w Transplant x Other non-neoplastic lung Neoplastic a Benign i Tumorlet ii Hamartoma iii Meningothelial-like nodule iv Sclerosing hemangioma v Inflammatory myofibroblastic tumor vi Clear cell (sugar) tumor (PEComa) vii Other benign non-neoplastic lung b Malignant i Squamous cell carcinoma ii Adenocarcinoma iii Small cell carcinoma iv Large cell carcinoma (other than neuroendocrine) v Giant cell carcinoma vi Lymphoepithelioma-like carcinoma vii Carcinosarcoma/pulmonary blastoma viii Neuroendocrine tumors ix Carcinoid x Atypical carcinoid xi Large cell neuroendocrine xii Bronchial gland tumors xiii Lymphoma xiv MALToma xv Lymphomatoid granulomatosis xvi Metastatic tumor lung xvi Other malignant non-neoplastic lung B Pleura Pleuritis and pleural plaque Solitary fibrous tumor Mesothelioma Metastatic carcinoma pleura Other pleura C Mediastinum Normal anatomy Inflammatory diseases a Mediastinitis 31554

27 Anatomic Pathology Page 27 of 34 3 Cysts (other than thymic) Thyroid and parathyroid diseases Thymus a Normal b Immunodeficiency c Cysts d Thymic hyperplasia e Thymoma i Myasthenia gravis ii Thymic carcinoma f Neuroendocrine tumors Germ cell tumors Lymphoma a Hodgkin lymphoma b Non-Hodgkin lymphoma c Other lymphoma Neurogenic tumors Paragangliomas Mesenchymal tumors mediastinum Other mediastinum XIV Central and Peripheral nervous system A Normal anatomy B Non-neoplastic Infections Developmental conditions Demyelinating disease Cerebrovascular disease Degenerative neurological disease a Alzheimer disease b Parkinson disease c Lewy body disease d Huntington disease e Other degenerative neurological disease Traumatic neuroma Other non-neoplastic central and peripheral nervous system C Neoplastic Cysts Gliomas a Astrocytoma b Pleomorphic xanthoastrocytoma c Oligodendroglioma d Ependymoma e Subependymoma f Other gliomas Neuronal tumors Pineal tumors 31634

28 Anatomic Pathology Page 28 of 34 5 Undifferentiated tumors a Medulloblastoma b Primitive neuroectodermal tumor c Other undifferentiated tumors Choroid Plexus tumors Meningeal tumors Peripheral nerve sheath tumors a Benign peripheral nerve sheath tumors b Malignant peripheral nerve sheath tumors Germ cell tumors Lymphoma/leukemia Metastatic tumors central and peripheral nervous system Other neoplastic central and peripheral nervous system XV Soft Tissue and Bone A Medical neuromuscular diseases Muscular dystrophy Congenital myopathies Inflammatory myopathies Metabolic disorders Other medical neuromuscular diseases B Soft tissue Normal anatomy Techniques Reactive lesions simulating sarcoma Fibrous/myofibroblastic a Benign fibrous/myofibroblastic lesions b Fibromatosis c Fibrous tumors of infancy/childhood d Fibrosarcoma e Benign fibrohistiocytic tumors f Fibrohistiocytic tumors of intermediate malignancy g Pleomorphic undifferentiated sarcoma Adipose tumors a Lipoma and variants b Liposarcoma Smooth muscle tumors a Leiomyoma and variants b Leiomyosarcoma Skeletal muscle tumors a Rhabdomyoma b Rhabdomyosarcoma Vascular tumors a Hemangioma and variants b Vascular tumors of intermediate malignancy c Malignant vascular tumors d Kaposi 31729

29 Anatomic Pathology Page 29 of 34 e Lymphatic tumor f Other vascular tumors Perivascular tumors Benign tumors of synovium Ewing sarcoma and related lesions Cartilaginous soft tissue tumors Osseous soft tissue tumors Benign soft tissue tumors of uncertain type Soft tissue tumors of intermediate malignancy of uncertain 15 type Malignant soft tissue tumors of uncertain type a Synovial sarcoma b Alveolar soft part sarcoma c Epithelioid sarcoma d Desmoplastic small round cell tumor e Solitary fibrous tumor f Clear cell sarcoma g Other malignant soft tissue tumors of uncertain type C Bone and Joint Non neoplastic bone a Metabolic disorders i Paget disease ii Osteogenesis imperfecta iii Osteomalacia/Rickets iv Hyperparathyroidism v Osteoporosis vi Other metabolic disorders b Fracture c Bone infarct d Osteomyelitis e Other non-neoplastic bone Neoplastic bone a Osteogenic tumors i Osteoid osteoma/osteoblastoma ii Osteosarcoma iii Other osteogenic tumors b Chondroid tumors i Osteochondroma ii Enchondroma iii Chondroblastoma iv Chondrosarcoma v Other chondroid tumors c Tumors of uncertain origin i Giant cell tumor ii Adamantinoma iii Other tumors of uncertain origin d Small cell tumors 31786

30 Anatomic Pathology Page 30 of 34 i Myeloma ii Lymphoma iii Ewing sarcoma e Vascular tumors i Hemangioma/variants ii Angiosarcoma f Miscellaneous neoplastic bone i Pleomorphic undifferentiated sarcoma ii Desmoplastic fibroma iii Chordoma iv Other miscellaneous neoplastic bone g Lesions simulating bone neoplasms i Metastatic carcinoma bone ii Aneurysmal bone cyst iii Benign cysts iv Fibrous dysplasia v Metaphyseal fibrous defects vi Other lesions simulating bone neoplasms Joints a Arthritis i Osteoarthritis ii Rheumatoid arthritis iii Osteonecrosis iv Gout v Calcium pyrophosphate crystal deposition disease vi Septic arthritis, including TB vii Wear debris arthropathy viii Other arthritis b Pigmented villonodular synovitis c Synovial chondromatosis d Ganglion cyst e Other joints XVI Skin A Non-neoplastic disease of skin Normal histology Inflammatory a Spongiotic dermatitis (allergic contact dermatitis) b Psoriasiform dermatitis(psoriasis) c Lichenoid dermatitis(lichen planus) d Vacuolar interphase dermatitis(lupus erythematosus, erythema multiforme) e Bullous and pustular disease(pemphigus) f Perivascular dermatitis (polymorphous light eruption) g Vasculitis 31840

31 Anatomic Pathology Page 31 of 34 h Diffuse dermal inflammation (Sweet syndrome, pyoderma gangrenosum) i Lipidoses j Granulomatous dermatitis k Diseases of hair follicles l Alterations of dermal collagen (Scar, keloid, scleroderma) m Panniculitis n Infectious o Other inflammatory skin B Non-melanocytic tumors Epidermal tumors a Benign epidermal tumors b Benign adnexal tumors c Malignant adnexal tumors d Premalignant and malignant epidermal tumors Connective tissue tumors a Dermatofibroma b Dermatofibrosarcoma protuberans c Atypical fibroxanthoma d Nerve sheath tumors e Other connective tissue tumors Vascular tumors Histiocytic tumors a Juvenile xanthogranuloma b Langerhans cell histiocytosis Hematolymphoid tumors Granular cell tumor Merkel cell tumor Other non-melanocytic tumors skin C Melanocytic tumors Benign melanocytic lesions a Acquired melanocytic nevi b Congenital melanocytic nevi c Spitz nevus and variants d Dermal melanocytic lesions i Blue nevus ii Cellular blue nevus iii Other dermal melanocytic lesions e Miscellaneous benign melanocytic lesions Malignant melanoma and precursor lesions a Dysplastic nevi b Melanoma XVII Molecular A Normal structure and function 31921

32 Anatomic Pathology Page 32 of 34 B Molecular Techniques and Methods FISH PCR qpcr microsatellite instability sequencing Use of FFPE C General principles of Molecular genetics Clonality Translocations Germline vs somatic Expression analysis Oncogenes, tumor suppressor genes QI, QC, and consultation Mutation Amplification Deletion D Ethical/legal/regulatory E Inherited disorders F Neoplastic disease G Hematopathology Leukemia a Lymphoid b myeloid Lymphoma a T cell b B cell H Solid tumors Breast cancer Lung cancer Colorectal cancer Gastric Thyroid cancer CNS Sarcoma I Heritable cancers Breast Lynch syndrome Retinoblastoma MEN syndomes Li-Fraumeni syndrome J Therapeutics Lung Colorectal Thyroid Other pharmacogenomics K Infectious Disease ID of pathogen noted on slide 32007

33 Anatomic Pathology Page 33 of 34 L Identity Use of molecular means for sample id (floater, sample mixup) M Histocompatibility N Bioinformatics XVIII Forensic A Natural Deaths Pediatric Deaths Cardiovascular System Chronic Alcoholism Central Nervous System Ocular System Respiratory System Head and Neck Genitourinary System Hematopoietic Lymphatic System Hepatic Gastrointestinal Pancreatic System Endocrine System Skin Bone, Joint, and Soft Tissue Peripheral Nerve and Skeletal Muscle Infectious Disease/Microbiology Immune Deficiency Disorders Nutritional Deficiencies Obesity B Unnatural Deaths Mechanical & Physical Injury Blunt Trauma Asphyxia Firearm Related Injuries Bombs and Explosions Sharp Injuries (Cutting & Stabbing) Electrical and Lightning Injuries Anaphylaxis Related Deaths Venom Related Deaths Deaths due to Changes in Atmosphere Heat/Cold Exposure Deaths Fire/Thermal Deaths Radiation Injuries & Deaths Chemical Injury: Including Toxicology and Postmortem 14 Chemistry Analytic Methods Interpretative: Autopsy & Chemical Environmental and Industrial Toxicology Identification of Human Remains Unnatural Deaths in Childhood Elder Abuse 33320

34 Anatomic Pathology Page 34 of Pregnancy Related Deaths Sex-Related Deaths Deaths from Compliations of Diagnostic and Therapeutic 23 Procedures Water-Related Deaths Psychiatric and Stress Related Deaths History and Development of Forensic Pathology & Legal 26 Medicine Jurisprudence and Certification of Death Criminalistics Bioterrorism and Chemical Agents Molecular Pathology Analytical Methods Transportation Related Deaths In-custody Deaths Postmortem Radiograhy Select Autopsy Topics 33395