TUMORS OF THE TESTICULAR ADNEXA and SPERMATIC CORD

Size: px
Start display at page:

Download "TUMORS OF THE TESTICULAR ADNEXA and SPERMATIC CORD"

Transcription

1 TUMORS OF THE TESTICULAR ADNEXA and SPERMATIC CORD Victor E. Reuter, MD Memorial Sloan-Kettering Cancer Center 66 th Annual Pathology Seminar California Society of Pathologists Short Course in Genitourinary Pathology MSKCC Disclosures: none

2 TESTICULAR APPENDAGES and CORD LESIONS Outline: Rete testis Tubuli efferentes/epididymis Mesothelium Soft tissue Metastatic disease

3 When confronted with an adnexal testicular mass, what should I be thinking about? Neoplastic or not? Reactive process, infection, infarct If neoplastic, primary or not? If primary, what type? Are there ancillary studies I can depend on? After I type it, what factors must I evaluate to predict progression and how do I stage the tumor? If metastatic, what are the more likely sources? Clinical history

4 METASTATIC DISEASE TO THE TESTIS Rarely is it the initial presentation of disease Epithelial tumors predominate Prostate Colon Kidney Melanoma Lymphoma Sarcoma

5 RETE TESTIS Benign Lesions Classification Hyperplasia Adenomatous hyperplasia Adenoma - Sertoliform adenoma Morphologic criteria Circumscribed Cystic or solid Cytologically banal For adenoma; not associated with other neoplasm

6 Normal anatomy

7 Pagetoid spread of ITGCN with reactive papillary hyperplasia of the rete

8 Reactive changes in the rete testis

9 Hilum Well circumscribed Banal appearing Inhibin /+ Sertoliform adenoma of the rete

10 PAX8

11 RETE TESTIS Adenocarcinoma Lesion centered in the hilum* Transition from normal to neoplastic epithelium* Absence of primary elsewhere Morphology incompatible with any other intrascrotal primary Proper immunohistochemical panel excluding other primaries *may be difficult to assess

12 RETE TESTIS Adenocarcinoma Clinical scenario: Adult males Unilateral painful testicular swelling With or without hydrocele Poor survival Pathology: Solid or cystic Mostly tubulopapillary (solid/spindled/reteform) Cuboidal to columnar cells Eosinophilic to basophilic cytoplasm

13

14

15 CK7 CEA CD15 PAX8

16 CYSTADENOMA OF THE EPIDIDYMIS vhl syndrome Sporadic Painless, movable mass Wide age distribution Variable size No hydrocele Microscopy: Papillary/tubulopapillary growth Clear cytoplasm Low grade nuclei Nuclei polarized towards the luminal surface

17 CYSTADENOMA OF THE EPIDIDYMIS CA9 CK7 PAX8

18 MÜLLERIAN-TYPE EPITHELIAL TUMORS Clinical scenario: Wide age range (adults) No specific medical history Painful testicular swelling Carcinomas may recur and metastasize Pathology: Solid or cystic Wide range of Mülleriantype morphologies Serous features dominate (endometrioid, clear,mucinous, Brenner) Entire histologic spectrum (cystadenomaborderline-carcinoma)

19 Müllerian rests/metaplasia

20 ER Müllerian rests/metaplasia within adnexa

21 Cystadenoma Serous borderline tumor

22 Papillary serous carcinoma

23 PARATESTICULAR SEROUS PAPILLARY CARCINOMA Cases 6 Age (yrs) 31 (16-42) Size (cm) 2 ( ) Presentation Mass 5 Hydrocele 1 Jones et al. Am J Surg Pathol.1995;19:

24 PARATESTICULAR SEROUS PAPILLARY CARCINOMA: Testicular groove* 4 Paratesticular soft tissue 1 Visceral tunica vaginalis 1 * two cases had extensive visceral tunica vaginalis involvement with invasion of the tunica albuginea Jones et al.am J Surg Pathol.1995;19:

25 Endometrioid carcinoma

26 ER WT-1 Positive: PR, CA125, CK7, CD15 Negative: CK20, Calretinin, CEA

27 LESIONS OF MESOTHELIAL ORIGIN Reactive changes Hyperplasia, cyst Mesothelioma Adenomatoid tumor

28 When confronted with a hydrocele sac, what should I be thinking about? If the urologist decides to send it to pathology What does the specimen look like? Thin or thick? Smooth or rough surface? What should I submit for morphology? Submit in toto or simply sample? What did the cyst fluid look like? What is the clinical history?

29 Reactive changes: Thickening Inflammation Mesothelial proliferation parallel to mesothelial surface

30 Reactive mesothelial hyperplasia Reactive changes: Thickening Inflammation Mesothelial proliferation parallel to mesothelial surface

31 Reactive mesothelial hyperplasia Respects the underlying muscular coat / no vertical growth

32 Mesothelioma Haphazard arrangement of cells Nodular of diffuse thickening Vertical growth

33 Mesothelioma CK 5/6 Calretinin WT-1 Seminiferous tubules

34 Mesothelioma; morphologic spectrum

35 What about benign papillary mesothelioma versus WD papillary mesothelioma? Beware of the word benign Minute, focal, cytologically banal, single cell layer, limited to the surface Complexity, solid component, and cytologic atypia warrant a diagnosis of mesothelioma

36 Papillary mesothelioma

37 Papillary mesothelioma

38 MESOTHELIOMA OF TUNICA VAGINALIS Clinicopathologic Features Cases 63 Age (yrs) mean 53.5, range 7-80 Presentation Asbestos exposure 48% Histology Local invasion hydrocele and/or mass 75% epithelial 25% biphasic skin of scrotum/penis, epididymis/testis, spermatic cord Jones et al. Am J Surg Pathol.1995;19:

39

40 MESOTHELIOMA OF TUNICA VAGINALIS Sites of Metastasis Site presentation later total (%) Lymph nodes retroperitoneum (38) inguinal (15) mediastinal 2 2 (4) Lung 8 8 (17) Peritoneum 3 3 ( 6) Liver 2 2 ( 4) Pelvic soft tissue 3 3 ( 6) Jones et al. Am J Surg Pathol.1995;19:

41 MESOTHELIOMA OF TUNICA VAGINALIS Outcome of Patients With Follow-up F/U (yrs) Patients DOD AWD NED < < < < < > Total 52 23(44%) 9(17%) 20(39%) Jones et al.am J Surg Pathol.1995;19:

42

43 WT1 Calretinin Also: CK5/6 D2-40

44

45 ADENOMATOID TUMOR - Well circumscribed, mobile - Not encapsulated Microscopy: - Epithelioid or spindled - Cords, nests, tubules - Microcystic, signet ring - No mitotic activity - May have intervening stroma or adnexal structure - May infarct - atypical myofibroblastic reaction Immunohistochemistry: - Like mesothelioma Differential Diagnosis: Mesothelioma, Adenoca.,YST

46 ADENOMATOID TUMOR Calretinin WT-1

47 ADENOMATOID TUMOR

48 MESENCHYMAL LESIONS OF THE SPERMATIC CORD Fibrous reactive versus neoplastic Lipomatous lipoma liposarcoma dedifferentiated Smooth muscle Squeletal muscle To also consider: Angiolipoma Angiofibroma Angiomyoblastoma Angiomyxoma

49 NODULAR PERIORCHITIS paratesticular fibrous pseudotumor Non neoplastic Nodular masses single, multiple, confluent Rarely diffuse Plaque-like May be massive and disfiguring Usually unilateral Gross features: Firm to hard, white

50 NODULAR PERIORCHITIS Microscopic features: Densely hyalinized collagen Clacification Well circumscribed May be somewhat cellular Inflammation Granulation tissue Differential diagnosis: Inflammatory pseudotumor Fibromatosis

51 Nodular periorchitis Fibrous Pseudotumor

52 LIPOMA OF THE SPERMATIC CORD

53 LIPOSARCOMA OF THE CORD - Most common sarcoma at this site - WD liposarcoma / atypical lipomatous tumor Gross appearance: - Variable, based of fatty, fibrous, or dedifferentiated component Microscopy: - Mature appearing adipocytes of varying size - Lipoblasts can be rare - Spindle and florrette-like cells - Fibrous bands are common - Dedifferentiation low grade high grade - Smooth muscle differentiation

54 Well differentiated Liposarcoma

55

56 Dedifferentiated liposarcoma, low grade

57 Dedifferentiated liposarcoma, high grade

58 Dedifferentiated Liposarcoma, low grade CDK4 MDM2

59 Retroperitoneal recurrence Dedifferentiated liposarcoma, now high grade CDK4 MDM2

60 Adnexal tumors: TESTICULAR APPENDAGES and CORD LESIONS Summary Rare; benign and reactive more common than malignant If epithelioid and malignant, consider a metastasis If primary, location, histology and IHC can help Adenocarcinoma (CEA, CD15, etc) Müllerian (ER, PAX8, WT1, CA125, etc) Mesothelioma (Calretinin, WT1, CK 5/6, Podoplanin) Soft tissue tumors: Beware of the subtle features of WD and low grade dedifferentiated liposarcoma Beware of benign mimics of liposarcoma and embryonal RMS

Case presentation: Mesothelioma of the tunica vaginalis. Dr Ben Shepherd Pathology Queensland Princess Alexandra Hospital Brisbane

Case presentation: Mesothelioma of the tunica vaginalis. Dr Ben Shepherd Pathology Queensland Princess Alexandra Hospital Brisbane Case presentation: Mesothelioma of the tunica vaginalis Dr Ben Shepherd Pathology Queensland Princess Alexandra Hospital Brisbane A 76 year old man presented June 2011 with a 6 month history of painless

More information

Update on Mesothelioma

Update on Mesothelioma November 8, 2012 Update on Mesothelioma Intro incidence and nomenclature Update on Classification Diagnostic specimens Morphologic features Epithelioid Histology Biphasic Histology Immunohistochemical

More information

MALIGNANT MESOTHELIOMA UPDATE ON PATHOLOGY AND IMMUNOHISTOCHEMISTRY

MALIGNANT MESOTHELIOMA UPDATE ON PATHOLOGY AND IMMUNOHISTOCHEMISTRY MALIGNANT MESOTHELIOMA CLASSIFICATION MALIGNANT MESOTHELIOMA UPDATE ON PATHOLOGY AND IMMUNOHISTOCHEMISTRY Sisko Anttila, MD, PhD Jorvi Hospital Laboratory of Pathology Helsinki University Hospital Espoo,

More information

MALIGNANT MESOTHELIOMA UPDATE ON PATHOLOGY AND IMMUNOHISTOCHEMISTRY

MALIGNANT MESOTHELIOMA UPDATE ON PATHOLOGY AND IMMUNOHISTOCHEMISTRY MALIGNANT MESOTHELIOMA UPDATE ON PATHOLOGY AND IMMUNOHISTOCHEMISTRY Sisko Anttila, MD, PhD Jorvi Hospital Laboratory of Pathology Helsinki University Hospital Espoo, Finland 2nd Nordic Conference on Applied

More information

PATHOLOGY OF THE PLEURA: Mesothelioma and mimickers Necessity of Immunohistochemistry. M. Praet

PATHOLOGY OF THE PLEURA: Mesothelioma and mimickers Necessity of Immunohistochemistry. M. Praet PATHOLOGY OF THE PLEURA: Mesothelioma and mimickers Necessity of Immunohistochemistry M. Praet Pathology of the Pleura Normal serosa: visceral and parietal layers Inflammation Neoplasia: Primary: mesothelioma

More information

Outline. Workup for metastatic breast cancer. Metastatic breast cancer

Outline. Workup for metastatic breast cancer. Metastatic breast cancer Metastatic breast cancer Immunostain Update: Diagnosis of metastatic breast carcinoma, emphasizing distinction from GYN primary 1/3 of breast cancer patients will show metastasis 1 st presentation or 20-30

More information

Today s Topics. Tumors of the Peritoneum in Women

Today s Topics. Tumors of the Peritoneum in Women Today s Topics Tumors of the Peritoneum in Women Charles Zaloudek, M.D. Department of Pathology 505 Parnassus Ave., M563 University of California, San Francisco San Francisco, CA USA charles.zaloudek@ucsf.edu

More information

Case of the. Month October, 2012

Case of the. Month October, 2012 Case of the Month October, 2012 Case The patient is a 47-year-old male with a 3-week history of abdominal pain. A CT scan of the abdomen revealed a suggestion of wall thickening at the tip of the appendix

More information

The develpemental origin of mesothelium

The develpemental origin of mesothelium Mesothelioma Tallinn 14.12.06 Henrik Wolff Finnish Institute of Occupational Health The develpemental origin of mesothelium Mesodermal cavities (pleura, peritoneum and pericardium ) are lined with mesenchymal

More information

Changes in Breast Cancer Reports After Second Opinion. Dr. Vicente Marco Department of Pathology Hospital Quiron Barcelona. Spain

Changes in Breast Cancer Reports After Second Opinion. Dr. Vicente Marco Department of Pathology Hospital Quiron Barcelona. Spain Changes in Breast Cancer Reports After Second Opinion Dr. Vicente Marco Department of Pathology Hospital Quiron Barcelona. Spain Second Opinion in Breast Pathology Usually requested when a patient is referred

More information

Immunohistochemistry on cytology specimens from pleural and peritoneal fluid

Immunohistochemistry on cytology specimens from pleural and peritoneal fluid Immunohistochemistry on cytology specimens from pleural and peritoneal fluid Dr Naveena Singh Consultant Pathologist Bart health NHS Trust London United Kingdom Disclosures and Acknowledgements I have

More information

Protocol for the Examination of Specimens From Patients With Tumors of the Peritoneum

Protocol for the Examination of Specimens From Patients With Tumors of the Peritoneum Protocol for the Examination of Specimens From Patients With Tumors of the Peritoneum Protocol applies to all primary borderline and malignant epithelial tumors and malignant mesothelial neoplasms of the

More information

PRIMARY SEROUS CARCINOMA OF PERITONEUM: A CASE REPORT

PRIMARY SEROUS CARCINOMA OF PERITONEUM: A CASE REPORT PRIMARY SEROUS CARCINOMA OF PERITONEUM: A CASE REPORT Dott. Francesco Pontieri (*) U.O. di Anatomia Patologica P.O. di Rossano (CS) Dott. Gian Franco Zannoni Anatomia Patologica Facoltà di Medicina e Chirurgia

More information

Diagnosis of Mesothelioma Pitfalls and Practical Information

Diagnosis of Mesothelioma Pitfalls and Practical Information Diagnosis of Mesothelioma Pitfalls and Practical Information Mary Beth Beasley, M.D. Mt Sinai Medical Ctr Dept of Pathology One Gustave L Levy Place New York, NY 10029 (212) 241-5307 mbbeasleymd@yahoo.com

More information

Effusions: Mesothelioma and Metastatic Cancers

Effusions: Mesothelioma and Metastatic Cancers Effusions: Mesothelioma and Metastatic Cancers Malignant Mesothelioma Incidence: 2,500 cases/year ~60-80% pts with pleural MM relationship with asbestos exposure Other risk factors: radiation, other carcinogens,

More information

The evolving pathology of solitary fibrous tumours. Luciane Dreher Irion MREH / CMFT / NSOPS

The evolving pathology of solitary fibrous tumours. Luciane Dreher Irion MREH / CMFT / NSOPS The evolving pathology of solitary fibrous tumours Luciane Dreher Irion MREH / CMFT / NSOPS Historical review Haemangiopericytoma (HPC) first described primarily as a soft tissue vascular tumour of pericytic

More information

Ovarian tumors Ancillary methods

Ovarian tumors Ancillary methods Ovarian tumors Ancillary methods Ovarian tumor course Oslo, 24-25/11/14 Prof. Ben Davidson, MD PhD Department of Pathology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway Division of

More information

Protocol applies to all primary borderline and malignant epithelial tumors, and malignant mesothelial neoplasms of the peritoneum.

Protocol applies to all primary borderline and malignant epithelial tumors, and malignant mesothelial neoplasms of the peritoneum. Peritoneum Protocol applies to all primary borderline and malignant epithelial tumors, and malignant mesothelial neoplasms of the peritoneum. Protocol revision date: January 2004 No AJCC/UICC staging system

More information

Diagnostic Challenge. Department of Pathology,

Diagnostic Challenge. Department of Pathology, Cytology of Pleural Fluid as a Diagnostic Challenge Paavo Pääkkö,, MD, PhD Chief Physician and Head of the Department Department of Pathology, Oulu University Hospital,, Finland Oulu University Hospital

More information

Something Old, Something New.

Something Old, Something New. Something Old, Something New. Michelle A. Fajardo, D.O. Loma Linda University Medical Center Clinical Presentation 6 year old boy, presented with hematuria Renal mass demonstrated by ultrasound & CT scan

More information

Notice of Faculty Disclosure

Notice of Faculty Disclosure The Diagnosis of Malignant Mesothelioma Andrew Churg, MD Department of Pathology University of British Columbia Vancouver, BC, Canada achurg@mail.ubc.ca Notice of Faculty Disclosure In accordance with

More information

Diseases. Inflammations Non-inflammatory pleural effusions Pneumothorax Tumours

Diseases. Inflammations Non-inflammatory pleural effusions Pneumothorax Tumours Pleura Visceral pleura covers lungs and extends into fissures Parietal pleura limits mediastinum and covers dome of diaphragm and inner aspect of chest wall. Two layers between them (pleural cavity) contains

More information

3-F. Pathology of Mesothelioma

3-F. Pathology of Mesothelioma 3-F. Pathology of Mesothelioma Kouki Inai Professor of Department of Pathology, Graduate School of Biomedical Science, Hiroshima University Introduction Mesothelioma is a peculiar type of malignancy, which

More information

Académie internationale de Pathologie - Division arabe XX ème congrès 24-26 novembre 2008 Alger. Immunohistochemistry in malignant mesotheliomas

Académie internationale de Pathologie - Division arabe XX ème congrès 24-26 novembre 2008 Alger. Immunohistochemistry in malignant mesotheliomas Académie internationale de Pathologie - Division arabe XX ème congrès 24-26 novembre 2008 Alger Immunohistochemistry in malignant mesotheliomas Françoise Thivolet-Béjui Groupement Hospitalier Est Lyon-Bron

More information

Introduction: Tumor Swelling / new growth / mass. Two types of growth disorders: Non-Neoplastic. Secondary / adaptation due to other cause.

Introduction: Tumor Swelling / new growth / mass. Two types of growth disorders: Non-Neoplastic. Secondary / adaptation due to other cause. Disorders of Growth Introduction: Tumor Swelling / new growth / mass Two types of growth disorders: Non-Neoplastic Secondary / adaptation due to other cause. Neoplastic. Primary growth abnormality. Non-Neoplastic

More information

Cytology : first alert of mesothelioma? Professor B. Weynand, UCL Yvoir, Belgium

Cytology : first alert of mesothelioma? Professor B. Weynand, UCL Yvoir, Belgium Cytology : first alert of mesothelioma? Professor B. Weynand, UCL Yvoir, Belgium Introduction 3 cavities with the same embryologic origin the mesoderme Pleura Exudates Pleura Peritoneum Pericardium 22%

More information

Pathology of the Female Peritoneum, Common and Uncommon Problems

Pathology of the Female Peritoneum, Common and Uncommon Problems Pathology of the Female Peritoneum, Common and Uncommon Problems An Update on Gynecologic Pathology Florence, Italy Anaís Malpica, M.D. Professor of Pathology Pathology of the Female Peritoneum Keratin

More information

Practical Effusion Cytology

Practical Effusion Cytology Practical Effusion Cytology A Community Pathologist s Approach to Immunocytochemistry in Body Fluid Cytology Emily E. Volk, MD William Beaumont Hospital Troy, MI College of American Pathologists 2004.

More information

SEMESTER VI 3 RD YEAR PATHOLOGY KIDNEY TUMORS

SEMESTER VI 3 RD YEAR PATHOLOGY KIDNEY TUMORS SEMESTER VI 3 RD YEAR PATHOLOGY KIDNEY TUMORS LEARNING OBJECTIVES At the end of the lecture, students should be able to: Know the pathology of renal tumors. RENAL TUMORS RENAL PAPILLARY ADENOMA Common

More information

Ovarian mucinous lesions. Ovarian mucinous lesions: Common diagnostic dilemmas. Ovarian mucinous lesions: problematic issues

Ovarian mucinous lesions. Ovarian mucinous lesions: Common diagnostic dilemmas. Ovarian mucinous lesions: problematic issues Ovarian mucinous lesions Ovarian mucinous lesions: Common diagnostic dilemmas Karuna Garg, MD University of California San Francisco Intestinal or usual type Seromucinous (Endocervical mucinous or Mullerian

More information

INFLAMMATORY PLEURAL EFFUSION

INFLAMMATORY PLEURAL EFFUSION PLEURA- LESIONS LESIONS OF PLEURA Primary Intra pleural bacterial infections Neoplasm (mesothelioma) Secondary A complication of some underlying disease PLEURAL EFFUSION Common manifestation of both primary

More information

MAJOR PARADIGM SHIFT IN EARLY 1990S IN UNDERSTANDING RENAL CANCER

MAJOR PARADIGM SHIFT IN EARLY 1990S IN UNDERSTANDING RENAL CANCER Renal tumours WHO 4 MAJOR PARADIGM SHIFT IN EARLY 1990S IN UNDERSTANDING RENAL CANCER Molecular differential pathology of renal cell tumours G. KOVACS A CLASSIFICATION BASED ON UNDERSTANDING THE GENETIC

More information

A. Pericardial smear. Examination of the pericardial aspirate can provide useful diagnostic information.

A. Pericardial smear. Examination of the pericardial aspirate can provide useful diagnostic information. 5. PERICARDIUM Heart is encased by the pericardium which has a visceral layer (a) covering the heart and the parietal layer (b). In normal states it is thin, transparent and the myocardium can be seen

More information

Case Report Mesothelioma of the tunica vaginalis testis with prominent adenomatoid features: a case report

Case Report Mesothelioma of the tunica vaginalis testis with prominent adenomatoid features: a case report Int J Clin Exp Pathol 2014;7(10):7082-7087 www.ijcep.com /ISSN:1936-2625/IJCEP0001992 Case Report Mesothelioma of the tunica vaginalis testis with prominent adenomatoid features: a case report Lian-He

More information

Effusions of the Serous Cavities

Effusions of the Serous Cavities Effusions of the Serous Cavities Annika Dejmek Professor/Consultant in Cytopathology Clinical Pathology; Department of Laboratory Medicine, Malmö, Lund University 5th EFCS Tutorial Trondheim 2012 Pleura

More information

Seattle. Case Presentations. Case 1. 76 year old female with a history of breast cancer 12 years ago. Now presents with a pleural effusion.

Seattle. Case Presentations. Case 1. 76 year old female with a history of breast cancer 12 years ago. Now presents with a pleural effusion. Seattle Montreal IAP September 2006 Case Presentations Allen M. Gown, M.D. Medical Director and Chief Pathologist PhenoPath Laboratories Clinical Professor of Pathology University of British Columbia Case

More information

Case presentation. Awatif Al-Nafussi

Case presentation. Awatif Al-Nafussi Case presentation Awatif Al-Nafussi Case History 49 year old DVT & small PE June 08, Pelvic mass Ca125 33 Laparotomy-TAHBSO, drainage of ascites Ovarian carcinoma Clinical diagnosis Multiple specimens

More information

Frozen Section Diagnosis

Frozen Section Diagnosis Frozen Section Diagnosis Dr Catherine M Corbishley Honorary Consultant Histopathologist St George s Healthcare NHS Trust and lead examiner final FRCPath Practical 2008-2011 Frozen Section Diagnosis The

More information

Neoplasms of the LUNG and PLEURA

Neoplasms of the LUNG and PLEURA Neoplasms of the LUNG and PLEURA 2015-2016 FCDS Educational Webcast Series Steven Peace, BS, CTR September 19, 2015 2015 Focus o Anatomy o SSS 2000 o MPH Rules o AJCC TNM 1 Case 1 Case Vignette HISTORY:

More information

DESMOPLASTIC SMALL ROUND CELL TUMOR: A RARE PATHOLOGY PUZZLE

DESMOPLASTIC SMALL ROUND CELL TUMOR: A RARE PATHOLOGY PUZZLE DESMOPLASTIC SMALL ROUND CELL TUMOR: A RARE PATHOLOGY PUZZLE Ryan Granger University of Rhode Island Cytotechnology program May 2, 2015 ASCT Annual Meeting Nashville, Tennessee DESMOPLASTIC SMALL ROUND

More information

Carcinosarcoma of the Ovary

Carcinosarcoma of the Ovary Carcinosarcoma of the Ovary A Rare Finding Presented By: Kathryn Kiely Anisa I. Kanbour School of Cytotechnology of the University of Pittsburgh Medical Center Pittsburgh, PA Patient History 55 year old

More information

Renal Tumors with Eosinophilic Cytoplasm: 2013 Classification. Jesse K. McKenney, MD Associate Head, Surgical Pathology

Renal Tumors with Eosinophilic Cytoplasm: 2013 Classification. Jesse K. McKenney, MD Associate Head, Surgical Pathology Renal Tumors with Eosinophilic Cytoplasm: 2013 Classification Jesse K. McKenney, MD Associate Head, Surgical Pathology Renal Epithelial Neoplasia History 1981: WHO Classification of Renal Neoplasms 1.

More information

Immunohistochemical differentiation of metastatic tumours

Immunohistochemical differentiation of metastatic tumours Immunohistochemical differentiation of metastatic tumours Dr Abi Wheal ST1. TERA 3/2/14 Key points from a review article written by Daisuke Nonaka Intro Metastatic disease is the initial presentation in

More information

Male. Female. Death rates from lung cancer in USA

Male. Female. Death rates from lung cancer in USA Male Female Death rates from lung cancer in USA Smoking represents an interesting combination of an entrenched industry and a clearly drug-induced cancer Tobacco Use in the US, 1900-2000 5000 100 Per Capita

More information

J of Evidence Based Med & Hlthcare, pissn- 2349-2562, eissn- 2349-2570/ Vol. 2/Issue 33/Aug. 17, 2015 Page 5063

J of Evidence Based Med & Hlthcare, pissn- 2349-2562, eissn- 2349-2570/ Vol. 2/Issue 33/Aug. 17, 2015 Page 5063 PERITONEAL MALIGNANT MESOTHELIOMA: A RARE S. R. Dhamotharan 1, S. Shanthi Nirmala 2, F. Celine Foustina Mary 3, M. Arul Raj Kumar 4, R. Vinothprabhu 5 HOW TO CITE THIS ARTICLE: S. R. Dhamotharan, S. Shanthi

More information

More than 2,500 people are diagnosed with mesothelioma in the UK each year.

More than 2,500 people are diagnosed with mesothelioma in the UK each year. This information is an extract from the booklet Understanding mesothelioma. You may find the full booklet helpful. We can send you a free copy see page 5. Contents Introduction Pleural mesothelioma Peritoneal

More information

The Diagnosis of Cancer in the Pathology Laboratory

The Diagnosis of Cancer in the Pathology Laboratory The Diagnosis of Cancer in the Pathology Laboratory Dr Edward Sheffield Christmas Select 74 Meeting, Queen s Hotel Cheltenham, 3 rd December 2014 Agenda Overview of the pathology of cancer How specimens

More information

659 Heart: 1 Atrial myxoma 1. Artery: 5 Normal 5. Vein: 1 Leiomyosarcoma well-differentiated (inferior vena cava) 1

659 Heart: 1 Atrial myxoma 1. Artery: 5 Normal 5. Vein: 1 Leiomyosarcoma well-differentiated (inferior vena cava) 1 Stony Brook BioBank Specimen Collection (updated 2//6) Site Diagnosis Cardiovascular System 659 Heart: Atrial myxoma Artery: 5 Normal 5 Blood: 652 Vein: Leiomyosarcoma well-differentiated (inferior vena

More information

Disclosures. Learning Objectives. Effusion = Confusion. Diagnosis Of Serous Cavity Effusions - Beware The Mesothelial Cell!

Disclosures. Learning Objectives. Effusion = Confusion. Diagnosis Of Serous Cavity Effusions - Beware The Mesothelial Cell! Disclosures Diagnosis Of Serous Cavity Effusions - Beware The Mesothelial Cell! No Relevant Financial Relationships with Commercial Interests Syed Z. Ali, M.D. Syed Z. Ali, M.D. Associate Professor of

More information

General Rules SEER Summary Stage 2000. Objectives. What is Staging? 5/8/2014

General Rules SEER Summary Stage 2000. Objectives. What is Staging? 5/8/2014 General Rules SEER Summary Stage 2000 Linda Mulvihill Public Health Advisor NCRA Annual Meeting May 2014 National Center for Chronic Disease Prevention and Health Promotion Division of Cancer Prevention

More information

Pathology of lung cancer

Pathology of lung cancer Pathology of lung cancer EASO COURSE ON LUNG CANCER AND MESOTHELIOMA DAMASCUS (SYRIA), MAY 3-4, 2007 Gérard ABADJIAN MD Pathologist Associate Professor, Saint Joseph University Pathology Dept. Hôtel-Dieu

More information

R-16: Chronic nonspecific cervisit

R-16: Chronic nonspecific cervisit R-16: Chronic nonspecific cervisit Ectoservikal squamous epithelium Endoservical columnar epithelium Dilated cystic endoservical glands lymphoplasmocytes R18:Squamous cell carcinoma insitu Neoplastic epithelium

More information

CASE OF THE MONTH AUGUST-2015 DR. GURUDUTT GUPTA HEAD HISTOPATHOLOGY

CASE OF THE MONTH AUGUST-2015 DR. GURUDUTT GUPTA HEAD HISTOPATHOLOGY CASE OF THE MONTH AUGUST-2015 DR. GURUDUTT GUPTA HEAD HISTOPATHOLOGY CASE HISTORY 52Y MALE RIGHT RADICAL NEPHERECTOMY Case of right renal mass with IVC thrombus. History of surgery and RT for right occipital

More information

MALIGNANT MESOTHELIOMA: A TYPICAL PRESENTATION IN AN ATYPICAL PATIENT

MALIGNANT MESOTHELIOMA: A TYPICAL PRESENTATION IN AN ATYPICAL PATIENT MALIGNANT MESOTHELIOMA: A TYPICAL PRESENTATION IN AN ATYPICAL PATIENT Written by: Karyn Varley MS, SCT(ASCP) The donating laboratory would like to remain anonymous. PATIENT HISTORY 28 year old female Lived

More information

Epithelial Tumors of the Kidney Diagnostic Problems and Recently Described Entities

Epithelial Tumors of the Kidney Diagnostic Problems and Recently Described Entities Pathology of Renal Neoplasia Epithelial Tumors of the Kidney Diagnostic Problems and Recently Described Entities Wael A Sakr, MD Wayne State University School of Medicine CURRENT CLASSIFICATION = EPITHELIAL

More information

Cytopathology Case Presentation #8

Cytopathology Case Presentation #8 Cytopathology Case Presentation #8 Emily E. Volk, MD William Beaumont Hospital, Troy, MI Jonathan H. Hughes, MD Laboratory Medicine Consultants, Las Vegas, Nevada Clinical History 44 year old woman presents

More information

HKCPath Anatomical Pathology Peer Review and Scores : PDF version for download

HKCPath Anatomical Pathology Peer Review and Scores : PDF version for download AP2003R1 http://hkcpath.org. Correspondence: pkhui@ha.org.hk 1of 10 07/08/2003 HKCPath Anatomical Pathology Peer Review and Scores : PDF version for download AP141 Bone Marrow: Metastatic Carcinoma from

More information

PROTOCOL OF THE RITA DATA QUALITY STUDY

PROTOCOL OF THE RITA DATA QUALITY STUDY PROTOCOL OF THE RITA DATA QUALITY STUDY INTRODUCTION The RITA project is aimed at estimating the burden of rare malignant tumours in Italy using the population based cancer registries (CRs) data. One of

More information

Histopathology of Major Salivary Gland Neoplasms

Histopathology of Major Salivary Gland Neoplasms Histopathology of Major Salivary Gland Neoplasms Sam J. Cunningham, MD, PhD Faculty Advisor: Shawn D. Newlands, MD, PhD Faculty Advisor: David C. Teller, MD The University of Texas Medical Branch, Department

More information

Immunohistochemistry of soft tissue tumors

Immunohistochemistry of soft tissue tumors Immunohistochemistry of soft tissue tumors Immunohistochemistry Major advances : antigen retrieval techniques (HIER) sensitive detection systems numerous antibodies of good quality Standardization : automated

More information

Diagnosis Of Serous Cavity Effusions - Beware The Mesothelial Cell! Effusion = Confusion

Diagnosis Of Serous Cavity Effusions - Beware The Mesothelial Cell! Effusion = Confusion Diagnosis Of Serous Cavity Effusions - Beware The Mesothelial Cell! Effusion = Confusion Syed Z. Ali, M.D. Professor of Pathology and Radiology The Johns Hopkins Hospital Baltimore, Maryland Diagnostic

More information

POSTMENOPAUSAL ASSESS AND WHAT TO DO

POSTMENOPAUSAL ASSESS AND WHAT TO DO POSTMENOPAUSAL OVARIAN CYSTS:HOW TO ASSESS AND WHAT TO DO Steven R. Goldstein, MD Professor of Obstetrics and Gynecology Director of Gynecologic Ultrasound Co-Director, Bone Densitometry New York University

More information

Primary -Benign - Malignant Secondary

Primary -Benign - Malignant Secondary TUMOURS OF THE LUNG Primary -Benign - Malignant Secondary The incidence of lung cancer has been increasing almost logarithmically and is now reaching epidemic levels. The overall cure rate is very low

More information

Malignant Peritoneal Mesothelioma in Women A Study of 75 Cases With Emphasis on Their Morphologic Spectrum and Differential Diagnosis

Malignant Peritoneal Mesothelioma in Women A Study of 75 Cases With Emphasis on Their Morphologic Spectrum and Differential Diagnosis Anatomic Pathology / MALIGNANT PERITONEAL MESOTHELIOMA IN WOMEN Malignant Peritoneal Mesothelioma in Women A Study of 75 Cases With Emphasis on Their Morphologic Spectrum and Differential Diagnosis Patricia

More information

Renal Cell Carcinoma: Advances in Diagnosis B. Iványi, MD

Renal Cell Carcinoma: Advances in Diagnosis B. Iványi, MD Renal Cell Carcinoma: Advances in Diagnosis B. Iványi, MD Department of Pathology University of Szeged, Hungary ISUP Vancouver Classification of Renal Neoplasia Am J Surg Pathol 37:14691489, 2013 13 histologic

More information

YOUR LUNG CANCER PATHOLOGY REPORT

YOUR LUNG CANCER PATHOLOGY REPORT UNDERSTANDING YOUR LUNG CANCER PATHOLOGY REPORT 1-800-298-2436 LungCancerAlliance.org A GUIDE FOR THE PATIENT 1 CONTENTS What is a Pathology Report?...3 The Basics...4 Sections of a Pathology Report...7

More information

Primary malignant gonadal mesotheliomas and asbestos

Primary malignant gonadal mesotheliomas and asbestos Histopathology 2000, 37, 150±159 Primary malignant gonadal mesotheliomas and asbestos R L Attanoos & A R Gibbs Department of Histopathology, University Hospital of Wales and Llandough Hospital, Cardiff,

More information

Case Report Predominantly Fibrous Malignant Mesothelioma in a Cat

Case Report Predominantly Fibrous Malignant Mesothelioma in a Cat SAGE-Hindawi Access to Research Volume 2010, Article ID 396794, 4 pages doi:10.4061/2010/396794 Case Report Predominantly Fibrous Malignant Mesothelioma in a Cat Alexander Th. A. Weiss, Afonso B. da Costa,

More information

Malignant mesothelioma of the pleura: relation

Malignant mesothelioma of the pleura: relation Thorax 1982;37:810-815 Malignant mesothelioma of the pleura: relation between histological type and clinical behaviour MR LAW, MARGARET E HODSON, BE HEARD From the Cardiothoracic Institute and Brompton

More information

METASTATIC CLEAR CELL RENAL CELL CARCINOMA TO THE SUBCUTANEOUS AREA IN ILLIAC FOSSA AND ADRENAL GLAND WITHOUT AN IDENTIFIABLE PRIMARY TUMOR

METASTATIC CLEAR CELL RENAL CELL CARCINOMA TO THE SUBCUTANEOUS AREA IN ILLIAC FOSSA AND ADRENAL GLAND WITHOUT AN IDENTIFIABLE PRIMARY TUMOR Indian J.Sci.Res. 5(1) : 121-125, 2014 METASTATIC CLEAR CELL RENAL CELL CARCINOMA TO THE SUBCUTANEOUS AREA IN ILLIAC FOSSA AND ADRENAL GLAND WITHOUT AN IDENTIFIABLE PRIMARY TUMOR a1 b c d REETA DHAR, SHILPI

More information

Cystic Neoplasms of the Pancreas: A multidisciplinary approach to the prevention and early detection of invasive pancreatic cancer.

Cystic Neoplasms of the Pancreas: A multidisciplinary approach to the prevention and early detection of invasive pancreatic cancer. This lecture is drawn from the continuing medical education program Finding Hope: Prevention, Early Detection and Treatment of Pancreatic Cancer, Nov, 2011. Robert P. Jury, MD Cystic Neoplasms of the Pancreas:

More information

Case Report Malignant Mesothelioma Mimicking Invasive Mammary Carcinoma in a Male Breast

Case Report Malignant Mesothelioma Mimicking Invasive Mammary Carcinoma in a Male Breast Case Reports in Oncological Medicine Volume 2015, Article ID 298523, 4 pages http://dx.doi.org/10.1155/2015/298523 Case Report Malignant Mesothelioma Mimicking Invasive Mammary Carcinoma in a Male Breast

More information

Plueral Malignancy: Radiologic-pathologic

Plueral Malignancy: Radiologic-pathologic Plueral Malignancy: Radiologic-pathologic Correlation Ritu R. Gill, MD Pleural Malignancies: Radiologic-Pathologic Correlation Ritu R Gill MD Brigham and Women s Hospital Boston, Massachusetts Pleural

More information

Histologic Subtypes of Renal Cell Carcinoma

Histologic Subtypes of Renal Cell Carcinoma Histologic Subtypes of Renal Cell Carcinoma M. Scott Lucia, MD Associate Professor Chief of Genitourinary and Renal Pathology Director, Prostate Diagnostic Laboratory Dept. of Pathology University of Colorado

More information

CHAPTER 2. Neoplasms (C00-D49) March 2014. 2014 MVP Health Care, Inc.

CHAPTER 2. Neoplasms (C00-D49) March 2014. 2014 MVP Health Care, Inc. Neoplasms (C00-D49) March 2014 2014 MVP Health Care, Inc. CHAPTER SPECIFIC CATEGORY CODE BLOCKS C00-C14 Malignant neoplasms of lip, oral cavity and pharynx C15-C26 Malignant neoplasms of digestive organs

More information

- Slide Seminar - Endocrine pathology in non-endocrine organs. Case 11. Stefano La Rosa, Gioacchino D Ambrosio, Fausto Sessa

- Slide Seminar - Endocrine pathology in non-endocrine organs. Case 11. Stefano La Rosa, Gioacchino D Ambrosio, Fausto Sessa - Slide Seminar - Endocrine pathology in non-endocrine organs Case 11 Stefano La Rosa, Gioacchino D Ambrosio, Fausto Sessa Dept. of Pathology, Multimedica, Milan, Italy Dept. of Surgical and Morphological

More information

Testicular Mesothelioma

Testicular Mesothelioma 5 Testicular Mesothelioma Alexander N. Zubritsky Moscow Russian Federation 1. Introduction The testicular mesothelioma is one of the rare tumor from other types of mesotheliomas (less than 1%)[9, 43, 81,

More information

Diagnostic Pitfalls In Thoracic Tumors

Diagnostic Pitfalls In Thoracic Tumors 1376 Diagnostic Pitfalls In Thoracic Tumors Neda Kalhor, MD Cesar A. Moran, MD, FASCP WEEKEND OF PATHOLOGY AMERICAN SOCIETY FOR CLINICAL PATHOLOGY 33 W Monroe Ste 1600 Chicago, IL 60603 Program Content

More information

Emerging Subtypes in Renal Cancer. Donna E. Hansel, MD PhD Professor of Pathology, UC San Diego Division Chief, Anatomic Pathology dhansel@ucsd.

Emerging Subtypes in Renal Cancer. Donna E. Hansel, MD PhD Professor of Pathology, UC San Diego Division Chief, Anatomic Pathology dhansel@ucsd. Emerging Subtypes in Renal Cancer Donna E. Hansel, MD PhD Professor of Pathology, UC San Diego Division Chief, Anatomic Pathology dhansel@ucsd.edu Some General Comments Fuhrman nuclear grading clear cell

More information

Objectives. Mylene T. Truong, MD. Malignant Pleural Mesothelioma Background

Objectives. Mylene T. Truong, MD. Malignant Pleural Mesothelioma Background Imaging of Pleural Tumors Mylene T. Truong, MD Imaging of Pleural Tumours Mylene T. Truong, M. D. University of Texas M.D. Anderson Cancer Center, Houston, TX Objectives To review tumors involving the

More information

ASBESTOS EXPOSURE AND SARCOMATOID MALIGNANT PLEURAL MESOTHELIOMA Gorantla Sambasivarao 1, Namballa Usharani 2, Tupakula Suresh Babu 3

ASBESTOS EXPOSURE AND SARCOMATOID MALIGNANT PLEURAL MESOTHELIOMA Gorantla Sambasivarao 1, Namballa Usharani 2, Tupakula Suresh Babu 3 ASBESTOS EXPOSURE AND SARCOMATOID MALIGNANT PLEURAL MESOTHELIOMA Gorantla Sambasivarao 1, Namballa Usharani 2, Tupakula Suresh Babu 3 HOW TO CITE THIS ARTICLE: Gorantla Sambasivarao, Namballa Usharani,

More information

Video Microscopy Tutorial 5

Video Microscopy Tutorial 5 Video Microscopy Tutorial 5 Lool Alikes in Effusion Cytology:Review of Diagnostic Challenges Claire Michael, MD There are no disclosures necessary. Look-Alikes in Effusion Cytology: Review of Diagnostic

More information

Paratesticular Embryonal Rhabdomyosarcoma; Report of a Case

Paratesticular Embryonal Rhabdomyosarcoma; Report of a Case Case Report Iran J Pediatr Dec 2009; Vol 19 (No 4), Pp:430-434 Paratesticular Embryonal Rhabdomyosarcoma; Report of a Case Sefa Resim* 1, MD; Nazan Okur 2, MD; Sevgi Bakarıs 3,MD; Ali Osman Kilic 1, MD;

More information

The menstrual cycle Hypophysis

The menstrual cycle Hypophysis Normal endometrium Tumors of the uterine corpus by MB The endometrium comprises the zona functionalis zf (superficial two thirds) ) and the zona basalis zb (deep one third) The zf responds to hormonal

More information

NEOPLASMS C00 D49. Presented by Jan Halloran CCS

NEOPLASMS C00 D49. Presented by Jan Halloran CCS NEOPLASMS C00 D49 Presented by Jan Halloran CCS 1 INTRODUCTION A neoplasm is a new or abnormal growth. In the ICD-10-CM classification system, neoplastic disease is classified in categories C00 through

More information

This module consists of four units which will provide the user a basic knowledge of cancer as a disease.

This module consists of four units which will provide the user a basic knowledge of cancer as a disease. Module 5: What is Cancer? This module consists of four units which will provide the user a basic knowledge of cancer as a disease. After completing this module, cancer abstractors will be able to: Define

More information

FRCPath Part 2 Histopathology Short Cases, autumn 2014

FRCPath Part 2 Histopathology Short Cases, autumn 2014 FRCPath Part 2 Histopathology Short Cases, autumn 2014 Commentary Case 1 Female age 52: palpable lesion, left breast Breast, fat necrosis. Average: 2.6/5 This case was chosen as a good example of fat necrosis

More information

MODERN IMMUNOHISTOCHEMISTRY

MODERN IMMUNOHISTOCHEMISTRY MODERN IMMUNOHISTOCHEMISTRY Cambridge Illustrated Surgical Pathology Peiguo G. Chu City of Hope National Medical Center, Duarte, California Lawrence M. Weiss City of Hope National Medical Center, Duarte,

More information

OBJECTIVES By the end of this segment, the community participant will be able to:

OBJECTIVES By the end of this segment, the community participant will be able to: Cancer 101: Cancer Diagnosis and Staging Linda U. Krebs, RN, PhD, AOCN, FAAN OCEAN Native Navigators and the Cancer Continuum (NNACC) (NCMHD R24MD002811) Cancer 101: Diagnosis & Staging (Watanabe-Galloway

More information

BIOBANK LPCE-NICE CHEST

BIOBANK LPCE-NICE CHEST BIOBANK LE-NIE HEST athologist :. BUTORI 12/09/2013 LE / HU Unit atient : N LH13-3603 N LB 13-0691 ID : RO A onsent : YES Age : 54 Diagnosis and staging : chronic pleuresia 5x1000µL BIOBANK LE-NIE HEST

More information

BIOBANK LPCE-NICE CHEST

BIOBANK LPCE-NICE CHEST BIOBANK LE-NIE HEST athologist : S. LASSALLE 01/03/2011 Time for frozen procedure : 10 mn LE / HU Unit atient : N LH 11-0004 N LB 11-0002 onsent : YES Age : 37 ID : TH ER Diagnosis and staging : Hodgkin

More information

CT and MRI features of the Pathologic Subtypes of Papillary Renal Cell Carcinoma. Melissa Price, MD Aoife Kilcoyne, MD Mukesh G.

CT and MRI features of the Pathologic Subtypes of Papillary Renal Cell Carcinoma. Melissa Price, MD Aoife Kilcoyne, MD Mukesh G. CT and MRI features of the Pathologic Subtypes of Papillary Renal Cell Carcinoma Melissa Price, MD Aoife Kilcoyne, MD Mukesh G. Harisinghani, MD Disclosures Neither I nor my immediate family members have

More information

Benign Breast Disorders

Benign Breast Disorders Benign Breast Disorders Valerie Swiatkowski, MD Medical Student Lecture Introduction 16% of women ages 40-69 will seek advice from their physician regarding breast complaints over 10 years. Failure to

More information

P L E U R A L M E S O T H E L I O M A

P L E U R A L M E S O T H E L I O M A For media outside the US, UK and Canada only P L E U R A L M E S O T H E L I O M A 1. Overview 2. What is pleural mesothelioma? 3. How common is pleural mesothelioma? 4. What are the risk factors for pleural

More information

Index. F Factor VIII-related antigen, see VWF FactorXIIIa, for dermatofibroma, 272-275 5-HT, see Serotonin

Index. F Factor VIII-related antigen, see VWF FactorXIIIa, for dermatofibroma, 272-275 5-HT, see Serotonin A Acantholytic squamous cell carcinoma vs epithelioid angiosarcoma, 56-57 Acinic cell carcinoma of pancreas, 76-77 vs ductal adenocarcinoma, 74-75 vs islet cell tumor, 78-81 Adenomatoid tumor vs hemangioma,

More information

Translocation Renal Cell Carcinomas

Translocation Renal Cell Carcinomas Translocation Renal Cell Carcinomas Cora N. Sternberg, MD, FACP Chair, Department of Medical Oncology San Camillo and Forlanini Hospitals Rome, Italy Kidney cancer is not a single disease Clear cell (75%)

More information

ATLAS OF HEAD AND NECK PATHOLOGY THYROID PAPILLARY CARCINOMA

ATLAS OF HEAD AND NECK PATHOLOGY THYROID PAPILLARY CARCINOMA Papillary carcinoma is the most common of thyroid malignancies and occurs in all age groups but particularly in women under 45 years of age. There is a high rate of cervical metastatic disease and yet

More information

BAP1 germline mutations A new Cutaneous Nevus Melanoma Syndrome. Thomas Wiesner

BAP1 germline mutations A new Cutaneous Nevus Melanoma Syndrome. Thomas Wiesner BAP1 germline mutations A new Cutaneous Nevus Melanoma Syndrome Thomas Wiesner Disclosure Listed as co-inventor US patent application US 61/463,389 BAP1 mutational analysis in determining susceptibility

More information

Mesothelioma: Questions and Answers

Mesothelioma: Questions and Answers CANCER FACTS N a t i o n a l C a n c e r I n s t i t u t e N a t i o n a l I n s t i t u t e s o f H e a l t h D e p a r t m e n t o f H e a l t h a n d H u m a n S e r v i c e s Mesothelioma: Questions

More information

Benign Liver Tumors. Cameron Schlegel PGY-1 3/6/2013

Benign Liver Tumors. Cameron Schlegel PGY-1 3/6/2013 Benign Liver Tumors Cameron Schlegel PGY-1 3/6/2013 Outline Benign Liver Tumors are, in general. Asymptomatic Diagnosed: imaging Treatment: Do no harm Unless Malignant potential Causing symptoms Differential

More information