Advanced International Breast Cancer Course

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1 SECTION OF ONCOLOGY 11 th MEET THE PROFESSOR Advanced International Breast Cancer Course PADUA, SEPTEMBER 10 th -11 th -12 th, 2015 Directors Pier Franco Conte, Gabriel N. Hortobagyi

2 Presentation Breast cancer represents the front runner in cancer research in many aspects. First, this is a common, chronic and lethal disease where medical interventions are successfully inducing a continuous decline in mortality in spite of increasing incidence. Second, biology drives the entire diagnostic-therapeutic work up of these patients. This is why, nowadays, a breast multidisciplinary team should also include pathologists, molecular biologists, oncogeneticists besides the classic clinical specialties. Third, many highly effective interventions are available for each step of the diagnostic and therapeutic work-up of these patients. The increased complexity of the disease, the availability of multiple effective choices and the high expectations of our patients are raising the bar of clinical excellence in this field. With this goal in mind, the Programme of this international Conference includes lectures on molecular characterization, updated treatments of early and advanced disease, management of difficult cases and hereditary syndromes. Clinical case discussions and debates are planned to allow a continuous and fruitful exchange of experiences and opinions between speakers and participants. This 11 th Breast Cancer Conference includes a highly qualified international faculty, but will maintain its characteristics of a friendly forum where international opinion leaders and attendees will exchange experiences and share the most exiting advances. In order to reward scientific excellence and to foster international cooperation, the International Scientific Committee of the 11 th AIBCC will award the 5 th International Prize for Breast Cancer Research to a scientist who has published a breakthrough paper in the previous year. We welcome medical oncologists, pathologists, breast surgeons, radiation oncologists and basic scientists to listen to breast cancer leaders and to exchange experiences in a friendly atmosphere. Addressed to Gynaecologists and obstretrics, medical oncologists, pathologists, radiation oncologists, radiologists, surgeons; biologists and nurses.

3 Programme Thursday, September 10 th 8.00 Registration 8.45 Introduction to the Conference Pier Franco Conte, Gabriel N. Hortobagyi SESSION I LIFE STYLE AND BREAST CANCER Chairmen: Gabriel N. Hortobagyi, Manuel Zorzi 9.00 Prevention of breast cancer with life style changes and drugs Alessandra Gennari 9.20 Life style after breast cancer diagnosis Giovanna Masala 9.40 Fertility and breast cancer Fedro Peccatori Q&A Coffee break SESSION II GENETIC TESTING Chairmen: Alberto Amadori, Sibylle Loibl BRCA: from genetic to predictive test Andrew Tutt BRCA: germline versus somatic mutations Claude Houdayer In and around the BRCA genes: the clinical relevance of variants of unknown significance and genetic modifiers Marco Montagna Multiplex germline mutation assays: ready for clinical use? Gabriel N. Hortobagyi Q&A Lunch SESSION III PATHOLOGY AND GENOMICS Chairman: Gabriel N. Hortobagyi Liquid biopsy : CTCs, ctdna, microrna Ready for prime time? François Clement Bidard

4 14.45 Clinical validity versus clinical utility of genomic tests Aleix Prat Discordant pathology and genomic data: what should drive the therapeutic choice? Giuseppe Viale Q&A Coffee break CUP syndrome Clinical Case Discussion I Chairmen: Fernando Bozza, Pier Franco Conte CUP cases will be presented and the audience will be asked to vote on different options Presenter of the cases: Maria Vittoria Dieci A panel composed by pathologists, radiologists, surgeons and medical oncologists will discuss the votes of the audience and express their opinions (Hesham Ahmed Gaballah Elghazaly, Carlos A. Garcia- Etienne, Gabriel N. Hortobagyi, Sibylle Loibl, Luigi Pescarini, Philip Poortmans, Corrado Tinterri) Adjourn Friday, September 11 th Imaging Clinical Case Discussion II Chairmen: Pier Franco Conte, Luigi Pescarini 8.30 Problematic/difficult cases of breast imaging will be presented. The presenters will ask the audience to express their opinion (voting system) Presenters of the cases: Alessandro Coran 8.50 A panel composed by radiologists, surgeons and clinicians will express their opinions and comment on the audience voting (Riccardo Audisio, Hesham Ahmed Gaballah Elghazaly, Carlos A. Garcia- Etienne, Gabriel N. Hortobagyi, Luigi Pescarini, Philip Poortmans, Corrado Tinterri)

5 Axillary Staging Clinical Case Discussion III Chairmen: Pier Franco Conte, Massimo Rugge 9.30 Cases of early breast cancer patients will be presented: extensive DCIS without infiltrating carcinoma, DCIS with multiple micro-filtrating foci, infiltrating carcinoma with micrometastatic SN, infiltrating carcinoma with different biologies with macrometastatic SN. The audience will be asked to vote on different options Presenter of the cases: Tania Saibene 9.50 A panel composed by pathologists, surgeons, medical and radiation oncologists will discuss the votes of the audience and express their opinion (Riccardo Audisio, Pier Franco Conte, Hesham Ahmed Gaballah Elghazaly, Carlos A.Garcia-Etienne Gabriel N. Hortobagyi, Sybille Loibl, Enrico Orvieto, Philip Poortmans, Corrado Tinterri, Giuseppe Viale) Coffee break SESSION IV SURGERY & RADIOTHERAPY Chairmen: Sibylle Loibl, Donato Nitti Oncoplastic surgery: opportunities and challenges Riccardo Audisio Risk reducing surgery: role in BRCAmut and BRCAwt patients Corrado Tinterri Update on radiation therapy (hypofractionation, boost, IORT, postmastectomy radiotherapy) Philip Poortmans Q&A Lunch SESSION V PREMENOPAUSAL EARLY BREAST CANCER Chairman: Gabriel N. Hortobagyi Management of very young patients Sibylle Loibl Adjuvant endocrine therapy after SOFT and TEXT trials Marco Colleoni Management of endocrine and sexual problems in young patients Giovanbattista Nardelli, Salvatore Gizzo

6 15.15 Pregnancy after breast cancer Lucia Del Mastro Q&A Ceremony for the presentation of the University of Padua Award for Advances in Breast Cancer Lecture of the Awardee Cocktail The Ceremony and the cocktail will take place in palazzo Bo, Via VIII Febbraio 2, Padua Saturday, September 12 th SESSION VI NEW THERAPEUTIC ALGORITHMS FOR ABC PATIENTS Chairmen: Pier Franco Conte, Gabriel N. Hortobagyi 9.00 HR+ ABC Stephen Johnston 9.30 HER2+ ABC Valentina Guarneri Triple negative advanced breast cancer Miguel Martin Coffee break Immunity and triple negative breast cancer Peter Schmid Immunity and HER2+ BC Gianpaolo Bianchini New promising check-point immunomodulators in solid tumors Filippo De Braud From development to access: how to harmonise sustainability, equanimity and innovation Jonas Bergh Q&A Adjourn and final evaluation questionnaire

7 Directors Pier Franco Conte Division of Medical Oncology 2 Department of Surgery, Oncology and Gastroenterology Gabriel N. Hortobagyi Department of Breast Medical Oncology University of Texas MD Anderson Cancer Center Houston (USA) Scientific Committee Jonas Bergh Department of Oncology-Pathology Karolinska Institute and University Hospital Stockholm (SW) Hesham Ahmed Gaballah Elghazaly Department of Clinical Oncology and nuclear medicine University of Ainshams Cairo (EG) Valentina Guarneri Division of Medical Oncology 2 Department of Surgery, Oncology and Gastroenterology Jacek Jassem Department of Oncology and Radiotherapy Medical University of Gdansk (PL) Sibylle Loibl German Breast Group Department of Medicine and Research University of Frankfurt (D) Miguel Martin Medical Oncology Service Hospital Universitario Gregorio Marañon Madrid (S) Donato Nitti Department of Surgery, Oncology and Gastroenterology Philip Poortmans President of ESTRO Department of Radiation Oncology Radbound University Medical Centre Nijmegen (NL) Stephen Johnston NIHR Biomedical Research Centre for Cancer Royal Marsden NHS Foundation Trust & Institute of Cancer Research London (UK)

8 Speakers Alberto Amadori Division of Oncological Molecular Diagnostic and Immunology Department of Surgery, Oncology and Gastroenterology Riccardo Audisio Department of Surgery St Helens Teaching Hospital Liverpool (UK) Jonas Bergh Department of Oncology-Pathology Karolinska Institute and University Hospital Stockholm (SW) Giampaolo Bianchini Department of Medical Oncology San Raffaele Hospital Milan (I) François-Clement Bidard Cancer Foundation Curie Institute Paris (F) Fernando Bozza Division of Breast Surgery Padua (I) Marco Colleoni Division of Medical Senology European Institut of Oncology (IEO) Milan (I) Pier Franco Conte Division of Medical Oncology 2 Department of Surgery, Oncology and Gastroenterology Alessandro Coran Breast Imaging Unit Padua (I) Filippo De Braud Department of Clinical Oncology National Cancer Institute Milan (I) Lucia Del Mastro Medical Oncology A- Innovative therapies development National Institute for Cancer Research Genoa (I) Maria Vittoria Dieci Division of Medical Oncology 2 Department of Surgery, Oncology and Gastroenterology Hesham Ahmed Gaballah Elghazaly University of Ainshams Department of Clinical Oncology and Nuclear Medicine Il Cairo (E) Carlos A. Garcia-Etienne Division of Breast Surgery S. Matteo Hospital Pavia (I) Alessandra Gennari Department of Medical Oncology Galliera Hospital Genova (I) Salvatore Gizzo Department of Gynecology and Obstetrics University Hospital Padua (I) Valentina Guarneri Division of Medical Oncology 2 Department of Surgery, Oncology and Gastroenterology Gabriel N. Hortobagyi Department of Breast Medical Oncology The University of Texas - MD Anderson Cancer Center Houston (USA)

9 Claude Houdayer Department de Biologie des Tumeurs - Service Genetique Institut Curie Paris (F) Stephen Johnston NIHR Biomedical Research Centre for Cancer Royal Marsden NHS Foundation Trust & Institute of Cancer Research London (UK) Sibylle Loibl German Breast Group Department of Medicine and Research University of Frankfurt (D) Miguel Martin Medical Oncology Service Hospital Universitario Gregorio Marañon Madrid (S) Giovanna Masala Molecular and Nutritional Epidemiology Unit Cancer Research and Prevention Institute-ISPO Florence (I) Marco Montagna Hereditary Tumors Group Breast and Ovary Cancer Department of Oncological Molecular Diagnostic and Immunology Giovanni Battista Nardelli Department of Gynecology and Obstetrics University Hospital Padova (I) Enrico Orvieto General Pathology & Cytopathology Unit Department of Medicine-DIMED University of Padua (I) Fedro Peccatori Department of Medical Oncology European Institute of Oncology Milan (I) Luigi Pescarini Department of Radiology Diagnostic Breast Unit Philip Poortmans President of ESTRO Department of Radiation Oncology Radbound University Medical Centre Nijmegen (NL) Aleix Prat Institute of Oncology (VHIO) Vall d Hebron Barcellona (E) Massimo Rugge General Pathology & Cytopathology Unit Department of Medicine-DIMED Tania Saibene Division of Breast Surgery Padua (I) Peter Schmid Centre for Experimental Cancer Medicine Bart Cancer Institute Queen Mary University London (UK) Corrado Tinterri Depatment of Senology Humanitas Clinical Institute Rozzano (I) Andrew Tutt Breast Cancer Research Unit Kings College London (UK) Giuseppe Viale Department of Pathology European Institute of Oncology University of Milan (I) Manuel Zorzi Cancer Registry of Veneto Padova (I)

10 Awards UNIVERSITY OF PADUA AWARD FOR ADVANCES IN BREAST CANCER 2015 The Scientific Committee will select young researchers (< 40 years from any country) who have published in an international peer-reviewed journal, as the principal author, a manuscript reporting important clinical or biological advances in breast cancer. Prof. Conte and Prof. Hortobagyi will select the final winner which will be invited to present his/her study during the annual Conference Under 35 Free admission is available for 3 persons Under 35. Registration forms will be accepted on a first-come, first-served basis until spaces are filled. The Organization Secretariat will confirm the registration by . Un azione sostenibile a favore della formazione Iscrizione gratuita per i medici UNDER 35 fino a esaurimento posti

11 CME Based on the in force Italian regulations, Accademia Nazionale di Medicina (provider n. 31) will assign to the activity CME ( ): 9,5 CME points. The Meeting is addressed to physicians specialized in: gynaecology and obstretrics, oncology, pathology, radiodiagnostics, radiotherapy, general surgery; biologists and nurses. It will not be possible to give credits to physicians specialized in different fields. The credit certification is subject to: attendance at the entire Meeting the completion of the meeting evaluation form the completion of the final questionnaire (at least 75% of correct answers) We would like to remind to participants that only 1/3 of CME credits acquired during the years 2014/2016 can come frome a sponsorship. ESMO-Mora Credits ESMO-Mora accreditation to be provided. Official Language The official language of the Meeting is English. No simultaneous translation will be provided.

12 Registration The registration fee is 250,00 tax free. It includes the conference bag, the conference book and all coffee breaks and lunches. It does not include Hotel accomodation, dinners and travel expenses. Under the article 54 T.U.I.R and within the limits set out therein, the costs of participation in this activity are deductible in determining self-employment income. To register, please send: registration form duly filled out (even when sponsored by a Pharmaceutical Company privacy statement and consent to the use of personal data (as in the back of the form) payment to Accademia Nazionale di Medicina Palazzina CUP II Piano, Via Massarenti 9, Bologna (fax e.mail: within August 24 th, Registration quote can be paid by: non-transferable cheque addressed to Accademia Nazionale di Medicina; bank transfer addressed to: ACCADEMIA NAZIONALE DI MEDICINA, Banca Prossima Spa - IBAN code: IT 35 Q SWIFT code: BCITITMX (indicate: Registration of Dr.... at Course 15_RE_ 1257); Credit Card Details Mastercard. Visa, Eurocard (NO AMEX cards). Online registration is possible on the website By submitting the form and the payment, your registration is completed with the exception of specific decisions of the Meeting Secretariat. Incomplete registration will NOT be admitted. The registration will be confirmed by , please put your address on the registration form. CANCELLATION if the participants minimum number is not reached, Accademia Nazionale di Medicina will advise by a written communication and proceed with the total refund of the fee. In order to cancel please give advise with a written communication to Accademia Nazionale di Medicina within 10 days from the beginning. A 70% of the registration fee will be returned. Any cancellation after that deadline will not be reimbursed.

13 Meeting Venue Centro Congressi Padova A. Luciani Via Forcellini 170/A Padova Tel / How to reach the meeting venue: By Car: The Highway exits are Padova Est, 5 Km from the Meeting Venue Padova Zona Industriale, 6 Km from the Meeting Venue By Train: Padova is in the Center of Veneto, it is easy to reach with the trains Milano- Venezia and Bologna-Venezia. The Meeting Venue is 4 Km from the train station By Plane Venezia Airport - Marco-Polo: 43 km (about 40 minutes by car) Treviso Airport- Canova: 63 km (about 50 minutes by car)

14 With the patronage of INSTITUTIONS Comune di Padova SCIENTIFIC SOCIETIES

15 With the unconditional contribution of GOLD SPONSOR SILVER SPONSOR BRONZE SPONSOR CONTRIBUTORS AMGEN BAYER EISAI PHARMA MAR PIERRE FABRE PHARMA SANDOZ

16 Sponsored by ACCADEMIA NAZIONALE DI MEDICINA General Manager: Stefania Ledda Organizing Partner Forum Service Via Martin Piaggio 17/ Genova Information: Ph Fax Hotel booking Ph

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