REACHING OUT THROUGH THE WEB MILAN BREAST CANCER CONFERENCE Webcast and residential. 23/26 june 2015

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1 REACHING OUT THROUGH THE WEB MILAN BREAST CANCER CONFERENCE Webcast and residential 23/26 june 2015 Tuesday 23 rd June 7.30 Registration 7.45 Opening session: W. Audretsch (Breast Center, Dusseldorf), K. B. Clough (Paris Breast Center, Paris) and J.Y Petit (European Institute of Oncology, Milan) Operating theatre n. 4: - Nipple sparing mastectomy and immediate reconstruction with implants or tissue expander. - Conservative breast cancer surgery and bilateral oncoplastic reshaping (1 or 2 cases) - Tissue expander replacement and nipple and areola reconstruction Operating theatre n. 5: - Breast reconstruction with pedicled TRAM flap. - Immediate breast reconstruction with implants and ADM (1 or 2 cases) - Fat grafting with the Coleman technique and Lipokit for refinements or total breast reconstruction. Coffee and lunch station in the exhibition area Final discussion The final program might change, depending on the patients recruitment. The dead time between surgeries will be used for discussion with chairmen, focusing on surgical tips and tricks and using edited videos. Wednesday, 24 th June 8.00 Operating theatre n. 4:

2 - Breast reconstruction with latissimus dorsi flap. - Sentinel node biopsy and axillary dissection. - Delayed breast reconstruction with implants. - Breast implant revisions 8.00 Operating theatre n. 5: - Bilateral reduction mammaplasty with inferior or superior pedicle. - Correction of breast asymmetry (Poland s Syndrome). - Breast implant revisions. - Nipple and areola reconstructions and fat grafting. Coffee and lunch station in the exhibition area Final considerations The final program might change, depending on the patients recruitment. The dead time between surgeries will be used for discussion with chairmen, focusing on surgical tips and tricks and using edited videos. Thursday 25 th June Opening Aron Goldhirsch (European Institute of Oncology, Milan) - Umberto Veronesi (European Institute of Oncology, Milan) 08.45/10.00 Imaging of breast cancer Chair Christiane Kuhl (University of Aachen, Aachen) Co-chair Enrico Cassano (European Institute of Oncology, Milan) 10.00/10.30 Coffee break Breast cancer screening: balancing benefits and harms Peter Juni (Institute of Social and Preventive Medicine, Bern) Checking response to treatments using MRI Christiane K. Kuhl (University of Aachen, Aachen) Checking response to treatments using PET scan Andreas Makris (Mount Vernon Cancer Centre, Northwood) Using x-ray imaging in BRCA1 & 2 carriers Andrea De Censi (E.O. Ospedali Galliera, Genova) Q&A 10.30/11.45 Pathology and molecular testing Chair Clifford Hudis (Memorial Sloan Kettering Cancer Center, New York) Co-chair Giuseppe Viale (European Institute of Oncology, Milan)

3 12.00/12.20 Spotlight 12.20/13.30 Lunch Why is it so difficult to standardize immunohistochemistry for breast cancer? Giuseppe Viale (European Institute of Oncology, Milan) How to deal with the heterogeneity of breast cancer? Nicholas Turner (Institute of Cancer Research, London) Are we ready for additional markers with therapeutic relevance? Clifford Hudis (Memorial Sloan Kettering Cancer Center, New York) When to prescribe gene signature testing (as opposed to relying upon immunohistochemistry)? Aleix Prat (Vall d'hebron Institute of Oncology, Barcelona) All you wanted to know about in situ neoplasia and you were afraid to ask Fraser Symmans (The University of Texas MD Anderson Cancer Center, Houston) Q&A What can we learn from proper pathology banking? Is it worth the cost? (examples) Barry Gusterson (Western Infirmary, Glasgow) 13.30/15.00 Surgery presentations Chair Viviana Galimberti (European Institute of Oncology, Milan) Co-chair Krishna Clough (Paris Breast Center, Paris) Breast surgery in very special clinical scenarios Oreste Gentilini (European Institute of Oncology, Milan) Is it time to declare close the era of the sentinel node biopsy? Roberto Agresti (Istituto Nazionale Tumori, Milan) Are surgical margins still important? Monica Morrow (Memorial Sloan Kettering Cancer Center, New York) Conservative surgery in multifocal cancer. Paolo Veronesi (European Institute of Oncology, Milan) Does risk-reducing surgery improve overall survival in BRCA1-2 mutation carriers? Mehra Golshan (Dana Farber Cancer Institute, Boston) Q&A EIO Award Krishna Clough (Paris Breast Center, Paris) 15.30/16.30 Post-operative adjuvant systemic therapies Chair Marco Colleoni (European Institute of Oncology, Milan) Co-chair Angelo Di Leo (Ospedale di Prato, Istituto Toscano Tumori, Prato) Treating patients with luminal A and B breast cancer William Gradishar (Northwestern University Feinberg School of Medicine, Chicago) Treating patients with HER2 positive breast cancer Harold Burstein (Dana Farber Cancer Institute, Boston) Treating patients with various types of triple negative breast cancer Angelo Di Leo (Ospedale di Prato, Istituto Toscano Tumori, Prato) Q&A

4 16.30/17.00 Coffee break 17.00/18.15 Adjuvant therapies for special populations with breast cancer Chair Giuseppe Curigliano (European Institute of Oncology, Milan) Co-chair Michelino De Laurentiis (IRCCS I.N.T. "Fondazione Giovanni Pascale", Napoli) Pregnancy and strong wish for child bearing and very young women Fedro Peccatori (European Institute of Oncology, Milan) Survivors of other malignancies Michelino De Laurentiis ((IRCCS I.N.T. "Fondazione Giovanni Pascale", Napoli) Autoimmune diseases with systemic relevance in cancer medicine Laurence Zitvogel (Institut National de la Santé et Recherche Médicale, Villejuif) Adjuvant therapies and co- morbidities: how to optimise the risk/benefit ratio Pierfrancesco Conte (Istituto Oncologico Veneto, Padova) Q&A 18.15/18.35 Spotlight Neoadjuvant treatments: how useful can it be? Marco Colleoni (European Institute of Oncology, Milan) Adjourn Friday 26 th June Interactive multidisciplinary corner Chair William Gradishar (Northwestern University Feinberg School of Medicine, Chicago) Co-chairs Aron Goldhirsch (European Institute of Oncology, Milan), Jay Harris (Dana-Farber Cancer Institute, Boston) 10.30/11.00 Coffee break Three clinical cases presentations: BRCA1 and 2 mutated Mattia Intra (European Institute of Oncology, Milan) Elderly patient Viviana Galimberti (European Institute of Oncology, Milan) Very young patient Oreste Gentilini (European Institute of Oncology, Milan) 11.00/12.15 Metastatic breast cancer Chair Pierfrancesco Conte (Istituto Oncologico Veneto, Padova) Co-chair Giuseppe Curigliano (European Institute of Oncology, Milan) Accelerating research for new drugs in advanced breast cancer (with examples) Giuseppe Curigliano How to stage women with advanced breast cancer avoiding abuse of imaging?

5 Carlo Tondini (Ospedale Papa Giovanni XXIII, Bergamo) Supportive care for women with advanced breast cancer: use and abuse Paolo Pronzato (IRCCS Azienda Ospedaliera Universitaria San Martino, Genova) Beyond second and third line therapies: a lawless jungle! Harold Burstein Q&A 12.15/12.40 Spotlight Surgery and other local treatments for the breast cancer and its metastases: how far can you go? Mattia Intra (European Institute of Oncology, Milan) 12.40/13.30 Lunch 13.30/14.45 Plastic surgery presentations Chair: Mario Rietjens (European Institute of Oncology, Milan) Co Chair: Francesca De Lorenzi (European Institute of Oncology, Milan) News on oncoplastic surgery. Krishna Clough (Paris Breast Center, Paris) Biological meshes in Breast reconstruction. Jian Farhadi (Guy s and St.Thomas Hospital, London) Up date on breast fat grafting. Jean Yves Petit (European Institute of Oncology, Milan) Lymphedema treatment combined with repair of the axillary and breast region by Microsurgery Corinne Becker (Champalimaud Cancer Center foundation for lymphedema and breast reconstruction, Ville d'avray) Q&A 14.45/15.05 The best poster session Chair Fabio Bassi (European Institute of Oncology, Milan) 15.05/15.30 Spotlight News from St. Gallen Marco Colleoni (European Institute of Oncology, Milan) 15.30/17.00 Radiotherapy session Chair Alphonse Taghian (Massachusetts General Hospital, Boston) Co-chair Roberto Orecchia (European Institute of Oncology, Milan) Q&A Conclusion Risk factors for local recurrences after breast conserving therapy Jay Harris (Dana-Farber Cancer Institute, Boston) Is radiation therapy needed after all? Roberto Orecchia (European Institute of Oncology, Milan) Target volume delineation and outcome after breast oncoplastic surgery Alan Fourquet (Institute Curie, Paris) Personalized radiotherapy in breast cancer Birgitte Offersen (Aarhus University Hospital, Aarhus) Side-effects of breast irradiation Alphonse Taghian (Massachusetts General Hospital, Boston)

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