INFLUENCE OF DEGENERATION AND REPAIR IN THE CNS AND PERIPHERY

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1 INTERNATIONAL WORKSHOP INFLUENCE OF DEGENERATION AND REPAIR IN THE CNS AND PERIPHERY PROGRAM Organized by the Experimental Section of the Hungarian Experimental and Clinical Pharmacology Society Date: September 24-25, 2009 Venue: Aranytíz Conference Center Budapest, Hungary

the Hungarian Experimental and Clinical Pharmacology Society Date:

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3 Workshop venue: Aranytíz Conference Center 1051 Budapest, Arany János utca 10. Tel: Fax: web site: Organizers: Prof Klára Gyires MD Phd DSc Department of Pharmacology and Pharmacotherapy Semmelweis University 1089 Budapest, Nagyvárad tér 4. Tel: Fax: Dr. Beáta Sperlágh MD Phd DSc Institute of Experimental Medicine Hungarian Academy of Sciences 1083 Budapest, Szigony u. 43. Tel: Fax: workshop website: 3

hu Organizers: Prof Klára Gyires MD Phd DSc Department of Pharmacology and Pharmacotherapy Semmelweis University 1089 Budapest, Nagyvárad tér 4.

4 PROGRAM Thursday Registration Opening remarks Session I. Chairs: Z. Fürst, P. Illes EPHAR Honorary lecture Thomas B. Bolton St. George's University of London, London, United Kingdom Smooth Muscle Excitation Peter Illes Rudolf-Boehm-Institut für Pharmakologie und Toxikologie, University of Leipzig, Leipzig, Germany P2X7 receptors and neuroprotection Tibor Zelles Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Early intracellular events in ischemia Coffee break Ana M. Sebastião Institute of Pharmacology and Neurosciences, Faculty of Medicine, University of Lisbon, Lisbon, Portugal Adenosine, neurotrophic factors and neurodegenerative diseases: new pieces for a puzzle 4

P2X7 receptors and neuroprotection 10 15-10 45 Tibor Zelles Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Early intracellular events in ischemia 10 45-11 15

5 Felicita Pedata Department of Pharmacology, University of Florence, Florence, Italy Adenosine A2A antagonists are protective in in vivo and in vitro models of brain ischemia Péter Mátyus Department of Organic Chemistry, Recent Progress in the Drug Therapy for Neurodegenerative Diseases - Some Challenging Aspects of Medicinal Chemistry Lunch and poster visit Session II. Chairs: K. Magyar, A. Sebastiao Veronika Ádám-Vizi Department of Medical Biochemistry, Reactive oxygen species and mitochondrial bioenergetics Dénes Zádori, László Vécsei Department of Neurology, University of Szeged, Szeged, Hungary Kynurenines, neurodegeneration and neuroprotection: drug development program Kálmán Magyar Department of Pharmacodynamics, Aminoxidases and their role in neuroprotection Csaba Ádori, Eszter Kirilly, György Bagdy Department of Pharmacodynamics, Semmelweis University, Budapest Axonal damage and recovery in the CNS: lessons from the effects of MDMA (ecstasy) Coffee break 5

6 Session III. Chairs: J. Szolcsányi, M. Tortarolo Zs. Helyes 1, Z Varecza 2, K. Elekes 1, T. László 3, L. Kereskai 3, A. Perkecz 1, E. Pintér 1, K. Sándor 1, T.F. Molnár 4, Z. Szántó 4, P.C. Emson 5, J.P. Allen 5, J. Szolcsányi 1 1 Departments of Pharmacology and Pharmacotherapy, 2 Immunology and Biotechnology, 3 Pathology, 4 Surgery Clinic, University of Pécs, Hungary 5 Laboratory of Molecular Neuroscience, The Babraham Institute, Cambridge, UK Somatostatin receptor subtype 4 (sst4) is a potential novel target for the inhibition of airway inflammation and hyperresponsiveness Massimo Tortarolo, Caterina Bendotti Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy Amyotrophic lateral sclerosis, a multifactorial and multicellular pathology, lesson from transgenic models of the disease László Siklós Institute of Biophysics, Biological Research Center, Szeged, Hungary Association of calcium buffering and immune/inflammatory reactions in determining vulnerability of motor neurons K. Király 1, B. Szalay 2, J. Szalai 1, I. Barna 3, K. Gyires 1, A.Z. Ronai 1 1 Department of Pharmacology and Pharmacotherapy, 2 1st Clinic of Pediatrics, Semmelweis University, Budapest, Hungary 3 HAS Institute of Experimental Medicine, Budapest, Hungary The antihyperalgesic action of intrathecal dipeptidyl peptidase IV inhibitor Ile-Pro-Ile is mediated by endomorphin 2 in the rat 6

Szolcsányi 1 1 Departments of Pharmacology and Pharmacotherapy, 2 Immunology and Biotechnology, 3 Pathology, 4 Surgery Clinic, University of Pécs, Hungary 5 Laboratory of Molecular Neuroscience, The

7 Z. S. Zádori, N. Shujaa, K. Gyires Department of Pharmacology and Pharmacotherapy, Centrally injected agmatine induces opioid-mediated gastroprotective effect in the rat Reception Friday Session IV. Chairs: K. Gyires, K. Rainsford E. Sylvester Vizi Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Effect of oxygen and glucose deficit on transmitter release Kim D. Rainsford Biomedical Research Centre, Sheffield Hallam University, Sheffield, United Kingdom NSAIDs and statins in prevention and treatment of Neurodegenerative Diseases Péter Ferdinandy Department of Biochemistry, University of Szeged, Szeged, Hungary Role of sensory nerves in myocardial adaptation to ischemic stress Klára Matesz Department of Anatomy, Histology and Embryology and HAS-UD Neuroscience Research Group, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary Extracellular matrix molecules and their possible role in the regeneration of central nervous system Coffee break 7

Chairs: K. Gyires, K. Rainsford 9 00-9 30 E.

8 Session V. Chairs: B. Sperlágh, F. Pedata Beáta Sperlágh Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Supradditive effect of mitochondrial dysfunction and oxidative stress on monoaminergic transmission in experimental models of neurodegenerative diseases Judit M. Molnár Clinical and Research Centre for Molecular Neurology Battery is not included: the management of the mitochondrial disorders A. Kovács, L. G. Hársing, G. Szénási Division of Preclinical Research, EGIS Pharmaceuticals PLC, Budapest, Hungary Focal brain ischaemia impairs cerebral vascular contractility probably via a ROS-mediated mechanism I. Miklya Department of Pharmacology and Pharmacotherapy, Evidence that (-)-deprenyl (selegiline) slows the deterioration of the nigrostriatal dopaminergic neurons in de novo parkinsonians because of its peculiar catecholaminergic activity enhancer (CAE) effect A. Szebeni 1, Z. Prohászka 2, E. Buzás 3, V. Kecskeméti 1 1 Department of Pharmacology and Pharmacotherapy, 2 IIIrd Department of Internal Medicine, Semmelweis University, Budapest, Hungary 3 Department of Genetics, Cell and Immunobiology, Effects of vaccination with heat shock proteins on Streptozotocin induced diabetes in histidine decarboxylase knockout mice Closing remarks 8

monoaminergic transmission in experimental models of neurodegenerative diseases 11 40-12 10 Judit M.

9 POSTERS 1 M. Aller, T. Horváth, G. Polony, Á. Fekete, G. Halmos, A. Heinrich, B. Sperlágh, B. Lendvai, E.S. Vizi, T. Zelles Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Different purinergic control of intracellular Ca 2+ concentration in the cells of the mouse organ of Corti 2 D. Á. Bán, A. Perkecz 2, É. Gömöri 3, T. Bíró 4, J. Szolcsányi 2, E. Pintér 2 1 School of Dentistry, 2 Department of Pharmacology, 3 Department of Pathology, Faculty of Medicine, University of Pécs, Pécs, Hungary 4 Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary Investigation of the role of neonatal capsaicin-desensitization in the mercury chloride (HgCl 2 ) induced lichenoid reaction of the rat mucosas 3 M. Baranyi, E. Milusheva, E. Kormos, B. Sperlágh Department of Pharmacology, Institute of Experimental Medicine, HAS, Budapest, Hungary Roles of antiparkinsonian drugs in the metabolism of H 2 O 2 evoked dopamine release in rat slice model 4 A. Deák 1, T. Bácskai 1, G. Veress 1,2, K. Matesz 1,3 1 Department of Anatomy, Histology and Embryology, 2 Department of Pathology, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary, 3 HAS-UD Neuroscience Research Group Effect of labyrinthectomy on the expression of extracellular matrix molecules in the vestibular nuclei of the rat 5 B. Gaál 1,2, É. Rácz 1, G. Veress 1, Gy. Székely 1,2, K. Matesz 1,2 1 Department of Anatomy, Histology and Embryology, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary, 2 HAS-UD Neuroscience Research Group Survey on the molecular composition of ECM around oculomotor neurons in the frog 9

2 D. Á. Bán, A. Perkecz 2, É. Gömöri 3, T. Bíró 4, J. Szolcsányi 2, E.

10 6 Zs. Hracskó, E. Milusheva, E. Kormos, B. Sperlágh Department of Pharmacology, Institute of Experimental Medicine, HAS, Budapest, Hungary The effect of antiparkinsonian drugs on rotenone-induced toxicity in rat striatal slices and PC12 cells 7 M. Pálfi, T. Tábi, K. Magyar, É. Szökő Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary Activity of FOXO transcription factors in response to cell stress 8 K. Sándor 1, V. Kormos 1, B. Botz 1, A. Imreh 1, K. Bölcskei 3, D. Reglődi 2, B. Gaszner 2, J. Szolcsányi 1, N. Shintani 4, H. Hashimoto 4, A. Baba 4, Zs. Helyes 1 Depts of 1 Pharmacology and 2 Anatomy, University of Pécs, 3 Analgesic Research Laboratory of the University of Pécs and Gedeon-Richter Ltd., Pécs, 4 Laboratory of Molecular Neuropharmacology, Osaka University Decreased nocifensive behaviours and mechanical allodynia, but enhanced thermal hyperalgesia in PACAP deficient mice 9 Szilvia Vas 1, Diana Kostyalik 1, Csaba Adori 1, Romeo D Ando 2 and Gyorgy Bagdy 1 1 Institute of Pharmacodynamics, Semmelweis University, 1085 Budapest, Hungary 2 Institute of Experimental. Medicine, Hungarian Academy of Sciences, Budapest, Hungary MDMA (ecstasy) causes a transient decrease in the expression of BDNF in the cerebral cortex 10

7 M. Pálfi, T. Tábi, K. Magyar, É. Szökő Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary Activity of FOXO transcription factors in response to cell stress 8 K. Sándor 1, V.

11 TECHNICAL INFORMATION The registration desk is open on 24 th September from 8.00 to and on 25 th September from 8.30 to Lectures will be held in the Nagylovagterem hall on the 1 st floor. The Poster session, coffee breaks, lunch and reception will be in the lounge of Nagylovagterem hall. For speakers, LCD projector and a laptop with Windows XP Professional will be provided. The size of the poster board is 1 m (width) x 2 m (height). Authors are asked to put their posters on by the beginning of the scientific session. 11

The Poster session, coffee breaks, lunch and reception will be in the lounge of Nagylovagterem hall.

12 SPONSORED by British Pharmacological Society 12

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