Collaborative Research Centre 796. Reprogramming of host cells by microbial effectors. 2. International Conference

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1 Collaborative Research Centre 796 Reprogramming of host cells by microbial effectors 2. International Conference Mechanisms of Microbial Host Cell Manipulation from Plants to Humans October Sunday, Oct. 4, :00 Registration 19:00 Welcome Uwe Sonnewald, Department Biology, Division Biochemistry, FAU, Germany 19:15 Evening lecture Otto Haller, Institute of Virology, University Medical Center, Freiburg, Germany Virus host competition: the interferon system as battleground 20:00 Poster Session Beer, Wine & Snacks Monday, Oct. 5, 2015 Session I: Manipulation of transport processes Chair: Anja Lührmann 09:00 Keynote lecture Craig R. Roy, Yale University School of Medicine, Department of Microbial Pathogenesis Microbial ménage à trois: Autophagy, mtor and Intracellular Infection

2 09:45 Andreas Bäumler, Dept. of Medical Microbiology and Immunology, UC Davis, USA The ER stress-induced pro-inflammatory response is mediated by the NOD1/NOD2 signaling pathway 10:10 Stefania Spano, University of Aberdeen, UK Salmonella typhi host restriction: a new antimicrobial mechanism behind? 10:35 Stefanie Hoffmann, Robert Koch Institute, Wernigerode, Germany Elevated activity of Salmonella Pathogenicity Islands (SPI) 1 and 4 in Salmonella dublin results in increased virulence 10:50 Stefan Wirtz, Medical Department 1, FAU, Germany T6SS-Mediated shaping of intestinal bacterial Communities confers effective Citrobacter rodentium infection 11:05 Coffee break Session I: Manipulation of transport processes Chair: Yves Muller 11:35 Keynote lecture Gabriel Waksman, Institute of Structural and Molecular Biology, University of London, UK Structural and Molecular Biology of Bacterial Secretion Systems 12:20 Milton Stubbs, University Halle-Wittenberg, Germany Insects do it differently: insights into Drosophila innate immune recognition from the Toll-Spätzle complex structure 12:45 Michael Hensel, Division Microbiology, University Osnabruck, Germany Good for food? Manipulation of the host cell endosomal system by Salmonella enterica 13:10 Lunch

3 Session II: Subversion of innate defense mechanisms Chair: Thomas Stamminger 14:15 Keynote lecture Edward Mocarski, Department of Microbiology and Immunology, Emory University, Atlanta, USA Subversion, Activation and Species Restriction of Necroptosis in Herpesvirus Infections 15:00 Hartmut Hengel, Albert-Ludwigs-University Freiburg, Germany Human Cytomegalovirus (HCMV)-encoded Fcγ-Receptors: Modulators at the Interface of Innate and Adaptive Immunity 15:25 Michaela Gack, Dept. of Microbiology and Immunology, Harvard Medical School, USA Regulatory mechanisms of viral RNA sensing pathways 15:50 Anja Friedrich, Department Biology, Division Biochemistry, FAU, Germany The Coxiella burnetii type IV effector protein CaeB is a across kingdoms cell death suppressor 16:05 Coffee Break Session II: Subversion of innate defense mechanisms Chair: Klaus Überla 16:35 Keynote lecture Jae U Jung, Mol Micro. & Immunol Department, Keck School of Medicine, University of Southern California, Los Angeles, USA Host Nucleic Sensing vs Vial Evasion 17:20 Thomas Stamminger, Institute of Clinical and Molecular Virology, FAU, Germany A viral G protein-coupled receptor interacts directly with TRAF6 to induce a highly regulated canonical NF-κB activation 17:45 Annette Niehl, Department of Environmental Sciences, University Basel, Switzerland Mechanisms of antiviral immunity in plants

4 19:15 Shuttle Service to Atzelsberg Departure: Zeitwohnhaus, Luitpoldstraße 10, Erlangen 19:30 Shuttle Service to Atzelsberg Departure: Ulmenweg 18, Erlangen 20:00 Conference Dinner, Atzelsberg Tuesday, Oct. 6, 2015 Session III: Manipulation of nuclear and cellular processes Chair: Uwe Sonnewald 09:00 Keynote lecture Michael Taliansky, James Hutton Institute, UK Nucleolar interaction between coilin and poly(adp-ribose) polymerase mediates anti-virus defence 09:45 Michelle Cilia, BTI Cornell, USA Mechanisms of host cell manipulation: from Plants to Humans 10:10 Michael Goodin, Dept. Plant Pathology, University of Kentucky, Lexington, USA Modification of nuclear architecture in plant cells infected with negative-strand RNA viruses 10:35 Max Kraner, Department Biology, Division Biochemistry, FAU, Germany Host targets of luteoviral protein in plants 10:50 Myriam Scherer, Institute of Clinical and Molecular Virology, FAU, Germany Formation of PML nuclear cages after infection with a human Cytomegalovirus IE1 mutant suggests genome entrapment as a cellular restriction mechanism of PML 11:05 Coffee break

5 Session III: Manipulation of nuclear and cellular processes Chair: Andrea Thoma-Kreß 11:30 Keynote lecture John Sinclair, Department of Medicine, University Cambridge, UK Latent carriage of human cytomegalovirus results in profound effects on cellular gene expression which can be targeted with novel therapeutics 12:15 Winfried Weissenhorn, Unit of Virus Host cell Interactions, UJF-EMBL-CNRS, Grenoble, France Structural basis of ESCRT-III and VPS4 action in budding 12:40 Björn Krenz, Department Biology, Division Biochemistry, FAU, Germany Quo vadis? Plant virus movement proteins in human and animal cells Lunch Session III: Manipulation of nuclear and cellular processes Chair: Alexander Steinkasserer 14:00 Agathe Subtil, Institute Pasteur, France Sequestration of host metabolism by an intracellular pathogen 14:25 Yves Muller, Department Biology, Division Biotechnology, FAU, Germany Insight into cytomegalovirus replication from structural biology 14:45 Manfred Marschall, Institute of Clinical and Molecular Virology, FAU, Germany The cytomegalovirus nuclear egresss protein pul50 defines the assembly of a multimeric viral-cellular egress complex 15:05 Andrea Thoma-Kreß, Institute of Clinical and Molecular Virology, FAU, Germany The Tax-inducible actin-bundling protein Fascin is required for release and cell-to-cell transmission of Human T-cell leukemia virus type 1 (HTLV-1) 15:25 Farewell address 15:40 Coffee - to- go