4. C. Schöniger, C. Arenz* "Perspectives in targeting mirna function" Bioorg. Med. Chem. 2013, im Druck, DOI: /j.bmc (IF = 2.
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1 Publications (IF = Impact factor, 2009 by JCR Science Foundation) I) Peer-reviewed Accepted Publications 1. N. H. T. Petersen, O. D. Olsen, L. Groth-Pedersen, A. M. Ellegaard, M. Bilgin, S. Redmer, M. S. Ostenfeld, D. Ulanet, T. H. Dovmark, A. Lønborg, S. D. Vindeløv, D. Hanahan, C. Arenz, C. S. Ejsing, T. Kirkegaard, M. Rhode, J. Nylandsted, M. Jäättelä *, Transformation-associated changes in sphingolipid metabolism sensitize cells to lysosomal cell death induced by inhibitors of acid sphingomyelinase Cancer Cell, (IF = 26.6) 2. A. A. Bastian, E. M. Warszawik, P. Panduru, C. Arenz and A. Herrmann* "Regioselective Diazo-Transfer Reaction at the C3-Position of the 2- Desoxystreptamine Ring of Neamine Antibiotics" Chem Eur J 2013, im Druck, DOI: /chem (IF = 5.9) 3. K. P. Bhabak, A. Hauser, S. Redmer, S. Banhart, D. Heuer, C. Arenz* "Development of a Novel FRET Probe for the Real-Time Determination of Ceramidase Activities" ChemBioChem 2013, im Druck, DOI: /cbic (IF = 3.8) 4. C. Schöniger, C. Arenz* "Perspectives in targeting mirna function" Bioorg. Med. Chem. 2013, im Druck, DOI: /j.bmc (IF = 2.8) 5. C. M. Dojahn, M. Hesse, C. Arenz* "Chemo-enzymatic Approach to specifically click-modified RNA" Chem. Commun. 2013, 49, (IF = 6.2) 6. K. P. Bhabak, B. Kleuser, A. Huwiler, C. Arenz* "Effective Inhibition of Acid and Neutral Ceramidases by Novel B-13 and LCL-464 analogues" Bioorg. Med. Chem. 2013, 21, (IF = 2.8) 7. K. P. Bhabak, C. Arenz * Novel Amide- and Sulfonamide-based Aromatic Ethanolamines: Effects of Various Substituents on the Inhibition of Acid and Neutral Ceramidases Bioorg. Med. Chem. 2012, 20, (IF = 2.8) 1
2 8. K. P. Bhabak, D. Proksch, S. Redmer, C. Arenz * Novel Fluorescent Ceramide Derivatives for Probing Ceramidase Substrate Specificity Bioorg. Med. Chem. 2012, 20, (IF = 2.8) 9. R. Samapati, Y. Yang, J. Yin, C. Arenz, A. Dietrich, T. Gudermann, D. Adam, S. Wu, C. Stoerger, V. Flockerzi, S. Uhlig *, W. Kübler * Regulation of lung vascular permeability by acid sphingomyelinase dependent activation of TRPC6, Am J Respir Crit Care Med. 2012, 185, (IF = 10.7) 10. M. Sand *, M. Skrygan, C. Arenz, D. Georgas, T. Gambichler, D. Sand, P. Altmeyer, F.G. Bechara Expression Levels of the microrna Maturing Microprocessor Complex Component DGCR8 and the RNA-Induced Silencing Complex (RISC) Components Argonaute-1, Argonaute-2, PACT, TARBP1, and TARBP2 in Epithelial Skin Cancer, Mol. Carcinog. 2011, published ahead of print, doi: /mc (IF = 3.2) 11. S. Neubacher, C.M. Dojahn, C. Arenz* A Rapid Assay for mirna Maturation Using Unmodified pre-mirna ChemBioChem, 2011, 12, (IF = 3.8) 12. D. Proksch, J.J. Klein, C. Arenz * Potent Inhibition of Acid Ceramidase by Novel B-13 Analogues, J. Lipids, 2011, DOI: /2011/ (IF = n.a., new journal) 13. S. Wetzel, W. Wilk, S. Chamma, B. Sperl, A.G. Roth, S. Renner, T. Berg, C. Arenz, T.I. Oprea, D. Rauh, M. Kaiser, and H. Waldmann *, Prospective Bioactivity Annotation by Scaffold Tree Merging Angew Chem. Int. Ed. 2010, 49, (IF = 11.8) 14. C. Arenz *, Small-Molecule Inhibitors of Acid Sphingomyelinase (Review) Cell. Phys. Biochem. 2010, 26, 1-8. (IF = 3.5) 15. T. Kirkegaard, A. G. Roth, N. H. T. Petersen, A. K. Mahalka, O. D. Olsen, I. Moilanen, A. Zylicz, J. Knudsen, K. Sandhoff, C. Arenz, P. K. J. Kinnunen, J. Nylandsted, M. Jäättelä *, Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology Nature 2010, 463, (IF = 34.5) 2
3 16. A. G. Roth, S. Redmer and C. Arenz* Carbohydrate-Derived Inhibitors of Acid Sphingomyelinase Bioorg. Med. Chem. 2010, 18, (IF = 2.8) 17. A. G. Roth, D. Drescher, Y. Yang, S. Redmer, S. Uhlig, C. Arenz* - Potent and Selective Inhibition of Acid Sphingomyelinase by Bisphosphonates, Angew. Chem. Int. Ed. 2009, 48, (IF = 11.8) 18. A. G. Roth, S. Redmer, C. Arenz* - Potent Inhibition of Acid Sphingomyelinase by Phosphoinositide Analogues ChemBioChem. 2009, 10, (IF = 3.8) 19. S. Neubacher, C. Arenz*, Rolling Circle Amplification Unshared Advantages in mirna Detection (Review), ChemBioChem 2009, 10, (IF = 3.8) 20. C.M. Klemm, A. Berthelmann, S. Neubacher, C. Arenz*, Short and Efficient Synthesis of Alkyne-Modified Amino Glycoside Building Blocks, Eur J. Org. Chem 2009, (IF = 3.1) 21. B.P. Davies, C. Arenz*, A Fluorescence Probe for Assaying Micro RNA Maturation, Bioorg. Med. Chem. 2008, 16, (IF = 2.8) 22. J.O. Babalola, M. Wendeler, B.Breiden, C. Arenz, G. Schwarzmann, S. Locatelli-Hoops, K. Sandhoff *, Development of an Assay for the Intermembrane Transfer of Cholesterol by Niemann-Pick C2 Protein, Biol. Chem. 2007, 388, (IF = 2.7) 23. C. Arenz*, Mikro RNAs Future DrugTargets? (Review), Angew. Chem. Int. Ed. 2006, 45, (IF = 11.8) 24. B.P. Davies, C. Arenz*, A Homogenous Assay of Micro RNA Maturation, Angew. Chem. Int. Ed. 2006, 45, (IF = 11.8) 25. C. Arenz, U. Schepers *, RNA Interference: from an ancient mechanism to a state of the art therapeutic application? (Review) Naturwissenschaften 2003, 90, (IF = 2.3) 3
4 26. M. Kölzer, C. Arenz, K. Ferlinz, N. Werth, H. Schulze, R. Klingenstein, K. Sandhoff * Phosphatidylinositol-3,5-Bisphosphate is a potent and selective inhibitor of acid sphingomyelinase Biol. Chem. 2003, 384, (IF = 2.7) 27. M. Diallo, C. Arenz, K. Schmitz, K. Sandhoff, U. Schepers *, Long endogenous dsrna can induce complete gene silencing in mammalian cell and primary cultures, Oligonucleotides 2003, 13, (IF = 2.5) 28. M. Diallo, C. Arenz, K. Schmitz, K. Sandhoff, U. Schepers*, RNA Interference: A new method to analyze the function of glycoproteins [ ] Meth. Enzymol. 2003, 363, (IF = 1.9) 29. C. Arenz, M. Gartner V. Wascholowski, A. Giannis *, Synthesis and Biological Investigation of Scyphostatin Analogues as Inhibitors of Neutral Sphingomyelinase Bioorg. Med. Chem. 2001, 11, (IF = 2.8) 30. C. Arenz, M. Thutewohl, O. Block, H. Waldmann, H.-J. Altenbach, A. Giannis *, Manumycin A and its Analogues Are Irreversible Inhibitors of Neutral Sphingomyelinase ChemBioChem 2001, 2, (IF = 3.8) 31. C. Arenz, A. Giannis *, Synthesis of the First Selective Irreversible Inhibitor of Neutral Sphingomyelinase Eur. J. Org. Chem. 2001, 1, (IF = 3.1) 32. C. Arenz, A. Giannis *, Synthesis of the First Selective Irreversible Inhibitor of Neutral Sphingomyelinase Angew. Chem. 2000, 112, (IF = 11.8) 4
5 II) Selected Non Peer-reviewed Publications 1. S. Bräse et al. Trendbericht Organische Chemie 2012 (Review) Nachr. Chem. 2013, 61, S. Bräse et al. Trendbericht Organische Chemie 2011 (Review) Nachr. Chem. 2012, 60, S. Bräse et al. Trendbericht Organische Chemie 2010 (Review) Nachr. Chem. 2011, 59, S. Bräse et al. Trendbericht Organische Chemie 2009 (Review) Nachr. Chem. 2010, 58, C. Arenz, O. Seitz *, Purines only a new Watson-Crick pairing mode in DNA (invited commentary), Chem. Biol., 2007, 14, C. Arenz *, Trendbericht Biochemie und Molekularbiologie 2005: Peptidnukleinsäuren in der Biomedizin (Review) Nachr. Chem. 2006, 54, C. Arenz, A.Giannis * "Design and Synthesis of Modulators of Sphingolipid Biosynthesis" in U. Diederichsen et. Al. (Ed.) Bioorganic Chemistry, Highlights and New Aspects, Wiley-VCH, Weinheim, 1999, III) Submitted Manuscripts and Manuscripts under Revision: 1. S. Voigt, S. Philipp, P. Davarnia, S. Winoto-Morbach, C. Röder, C. Arenz, A. Trauzold, D. Kabelitz, S. Schütze, H. Kalthoff and D. Adam* TRAIL-induced programmed necrosis as a novel approach to eliminate tumor cells Int. J. Cancer, submitted Manuscript # IJC
6 IV) Patents 1. C. Arenz*, B. P. Davies, S. Neubacher, C. M. Klemm MiRNA processing inhibitor efficacy assays and substances US60/961, C. Arenz*, A. G. Roth, D. Drescher, S. Uhlig Inhibition of Acid Sphingomyelinase by Bisphosphonates Patent filed 08/ C. Arenz*, D. Proksch Synthesis of novel sphingosine derivatives Patent filed 04/
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