Webserver: bioinfo.bio.wzw.tum.de Mail:
|
|
- Cameron Garrison
- 8 years ago
- Views:
Transcription
1 Webserver: bioinfo.bio.wzw.tum.de Mail:
2 About me H. Werner Mewes, Lehrstuhl f. Bioinformatik, WZW C.V.: Studium der Chemie in Marburg Uni Heidelberg (Med. Fakultät, Bioenergetik) EMBL Heidelberg (Proteinchemie, Prof. Tsugita) MPI f. Biochemie, Martinsried (Proteinchemie, Dr. Lottspeich) Seit 1988 in der Bioinformatik: Proteinsequenzen, Genomanalyse, Seit 2001 Lehrstuhl f. Bioinformatik am WZW Weihenstephan Direktor des Instituts f. Bioinformatik und Systembiologie am Helmholtz Zentrum München (Dt. Zentrum f. Gesundheit u. Umwelt) Arbeitsgebiete: Genomanalyse, Biol. Wissen, Systembiologie Publikationen/Web Site: mips.gsf.de // binfo.bio.wzw.tum.de 2
3 Rules for this lecture Do not redistribute course material, it is subject to copyright (less mine than others) but in a closed group (students of this lecture) private use is allowed. Please do not disturb your neighbours (and me). Some students may be interested in the subject. 3 Photo: KoAn (cc)
4 About this lecture Goals: To understand that bioinformatics is a pure necessity to understand biological processes To get an idea that bioinformatics and experimental biology will become part of Systems Biology (and what that is) To understand that intuition is probably not an ideal solution to solve complex problems Webserver: bioinfo.bio.wzw.tum.de Mail: w.mewes@weihenstephan.de 4
5 About this lecture Bioinformatics for Biologists: Biology is the driving force, but bioinformatics is a powerful enabling techologie and science by itself Less (but not no) algorithms Mark the hot spots that you should understand & know Understand what bioinformatics can do for you Wider scope than previous lectures Different type of exercises (T. Rattei, P. Pagel) Webserver: bioinfo.bio.wzw.tum.de Mail: w.mewes@weihenstephan.de 5
6 Topics of the Lecture 6
7 Mind Map for this Lecture 7
8 THE GRAND CHALLENGE IS: TO DO SOMETHING HAVING AN IMPACT BEYOND THE NEXT DAY
9 Multifactorial diseases in a changing world Climate & Ecosystems Global Economy Socioeconomics & Demographics Behavior & Life style? Well Being Health Diseases
10 Guess what this is?
11 The burden of diabetes
12 Weight watchers 12
13 Different Views to Human Health
14 From intuitive interpretation to desperation
15 DISEASES AND THEIR ORIGIN
16 A single cause? Overexpressing a particular microrna in some of a mouse's immune cells leads to leukemia Couzin, Science, 2008
17 Factors influencing diseases Genes Genetic variance (disposition) Regulation Transcription Translation (e.g. mirna) Splicing Post-translational modifications Signaling Epigenetic Histone modification Development Environmental factors Nutrients, toxins, drugs Behavior (exercise) Nutrition Infection Stress Aging
18 Genetic, cellular and molecular basis of disease Diseases are disorders of homeostasis To understand the molecular mechanisms involved in aitiology and progress of diseases we need information from the molecule to the population Photo Yuri Tand Methods, technologies, and discoveries supported by bioinformatics
19 What will happen in the Life Sciences within 10 years? The principle of the Black Swan (N.N. Taleb) As a matter of fact: we don`t know what will happen (we never know the improbable) If we explain 99% we will not find the 1% causing dramatic changes: what makes the change? A single mirna may cause dramatic effects However, we can at least extrapolate Massive amounts of data New technologies: Deep sequencing Imaging High resolution and dynamic structures New approaches to biological problems 19
20 What we want to know about biology? Life as a process depends on Laws (chemistry, physics) Principles (DNA, RNA, Protein) Rules (cis-splicing) Exceptions (trans-splicing) What can we observe? Phenotypes (any observable) conditon & time dependent Genotypes Given the molecular level as the level of action how can we find the cause for macro-observable phenotypes? 20
21 WHAT IS BIOINFORMATICS GOOD FOR?
22 How to become? [PDF] Basic local alignment search tool SF Altschul, W Gish, W Miller, EW Myers, DJ Lipman - J. Mol. Biol, puffer.g J. Mol. Biol. (1990) 215, Basic Local Alignment Search Tool Stephen F. Altschul1, Warren Gish1, Webb Miller2 Eugene W. Myers3 and David J. Lipman1 National Center for Biotechnology Information National Library of Medicine,... Zitiert durch: Weitere Artikel - Websuche - Alle 59 Versionen Gapped BLAST and PSI-BLAST: a new generation of protein database search prog SF Altschul, TL Madden, AA Schaffer, J Zhang, Z - Nucleic Acids Research - O Variations of the BLAST algorithm (1 ) have been incorporated into several popular programs for searching protein and DNA databases for sequence similarities. BLAST programs have been written to compare protein or DNA... Zitiert durch: Weitere Artikel - Websuche - Alle 146 Versionen [ZITATION] Basic local alignment tool SF Altschul, W Gish, W Miller, EW Myers, DJ Lipman - J. Mol. Biol, 1990 Zitiert durch: Weitere Artikel - Websuche Detecting subtle sequence signals: a Gibbs sampling strategy for multiple alignmen CE Lawrence, SF Altschul, MS Boguski, JS Liu, AF - Science, sciencem Diels and K. Alder, Justus Liebigs Ann. Chem. 460, 98 (1928); 0. Diels, JH Blom, W. Koll, ibid. 443, 242 (1925); BM Trost, I. Fleming, LA Paquette, Comprehensive Organic Synthesis (Pergamon, Oxford, 1991), vol. 5, pp. 316;... Zitiert durch: Weitere Artikel - Websuche - Alle 15 Versionen Methods for Assessing the Statistical Significance of Molecular Sequence Features [PDF] S Karlin, SF Altschul - Proceedings of the National Academy of Sciences, N Page 1. Proc. Natl. Acad. Sci. USA Vol. 87, pp , March 1990 Evolution Methods for assessing the statistical significance of molecular sequence features by using general scoring schemes... Zitiert durch: Weitere Artikel - Websuche - Alle 26 Versionen
23 Information vs. Complexity 23
24 Bioinformatics classics 24
25 The secrets of bioinformatics Taken from G. Brooch OO-Programming 25
26 A molecular interaction map qualitative and quantitative modeling 26 Kohn et al.; Mol. Biol. Cell (2006)
27 What is Bioinformatics? Bioinformatics is a newly emerging interdisciplinary research area which may be defined as the interface between biological and computational sciences. Thus, the people working in this field in most cases either have a training in biology or computer science, and they learned about the other field by dealing with problems or using the tools of the other one. I see it much different: bioinformatics is about concepts. We apply these concepts in a very general approach to biological questions. It is not relevant what we use to solve the question: text mining, algorithms, huge storage space, differential equations. In most cases we use computer and network technologies. There is no general paradigm for a definition of bioinformatics (see the concept of systems biology following later). It is truly interdisciplinary. 27
28 Again: What is Bioinformatics? Bioinformatics is an integration of mathematical, statistical and computer methods to analyze biological, biochemical and biophysical data. Bioinformatics and computational biology involve the use of techniques including applied mathematics, informatics, statistics, computer science, chemistry and biochemistry to solve biological problems usually on the molecular level. Research in computational biology often overlaps with systems biology.. Wikipedia! 28
29 History and Outlook 70ies: collect data and store on a computer instead of cards; first pioneering efforts in protein comparison 80ies: DNA sequencing, collection of sequence data, first databases (PIR, GenBank, EMBL); algorithms for sequence comparison and sequence analysis 90ies: First complete genomes sequenced; genome analysis, explosion of information; prediction of function; annotation of sequences; functional and structural classification; protein domains; gene prediction; function prediction; probabilistics Computational Biology: apply algorithms for discovery Systems Biology: understanding biological networks 29
30 Keywords Major research efforts in the field include sequence alignment, gene finding, genome assembly, protein structure alignment, protein structure prediction, prediction of gene expression and protein-protein interactions, and the modeling of evolution But: Since people are working in the field, things get complex! 30
31 Basic bioinformatics goals Can we provide a general solution for a problem? To measure the similarity of two sequences To classify a protein for its function To assign a fold to a protein Can we make discoveries in biology using bioinformatics? Are certain protein families unique for certain species? Does the conservation of pairs of proteins correlate to certain sets of species? Note: if you have a realy interesting question: bioinformatics can provide information but is hardly suitable to get you a nobel price (without using other tricks) example: prediction of protein/protein interactions 31
32 Bioinformatics is an interdisciplinary adventure Bioinformatics is about biology. Life is the most important and complex object to study. Experiments Data Databases To give reliable answers to biological questions, bioinformatics needs computer science to solve difficult (hard) problems. Data Algorithms Information The genome era is data driven. Huge amounts of complex data have to be analyzed and interpreted. Data & Knowledge Algorithms Interpretation Next step: Systems Biology: why is a cell more than a soup of molecules? Qualitative and quantitative models 32
33 END OF CHAPTER ONE
AC 2007-305: INTEGRATION OF BIOINFORMATICS IN SCIENCE CURRICULUM AT FORT VALLEY STATE UNIVERSITY
AC 2007-305: INTEGRATION OF BIOINFORMATICS IN SCIENCE CURRICULUM AT FORT VALLEY STATE UNIVERSITY Ramana Gosukonda, Fort Valley State University Assistant Professor computer science Masoud Naghedolfeizi,
More informationVad är bioinformatik och varför behöver vi det i vården? a bioinformatician's perspectives
Vad är bioinformatik och varför behöver vi det i vården? a bioinformatician's perspectives Dirk.Repsilber@oru.se 2015-05-21 Functional Bioinformatics, Örebro University Vad är bioinformatik och varför
More informationRETRIEVING SEQUENCE INFORMATION. Nucleotide sequence databases. Database search. Sequence alignment and comparison
RETRIEVING SEQUENCE INFORMATION Nucleotide sequence databases Database search Sequence alignment and comparison Biological sequence databases Originally just a storage place for sequences. Currently the
More informationThe College of Liberal Arts and Sciences
The College of Liberal Arts and Sciences Proposal for a Biomedical Sciences Major (BS) Professor Bernd Fritzsch, DEO, Department of Biology Associate Professor Bryant McAllister, DUS, Department of Biology
More informationDatabase searching with DNA and protein sequences: An introduction Clare Sansom Date received (in revised form): 12th November 1999
Dr Clare Sansom works part time at Birkbeck College, London, and part time as a freelance computer consultant and science writer At Birkbeck she coordinates an innovative graduate-level Advanced Certificate
More informationBiochemistry Major Talk 2014-15. Welcome!!!!!!!!!!!!!!
Biochemistry Major Talk 2014-15 August 14, 2015 Department of Biochemistry The University of Hong Kong Welcome!!!!!!!!!!!!!! Introduction to Biochemistry A four-minute video: http://www.youtube.com/watch?v=tpbamzq_pue&l
More informationJust the Facts: A Basic Introduction to the Science Underlying NCBI Resources
1 of 8 11/7/2004 11:00 AM National Center for Biotechnology Information About NCBI NCBI at a Glance A Science Primer Human Genome Resources Model Organisms Guide Outreach and Education Databases and Tools
More informationBBSRC TECHNOLOGY STRATEGY: TECHNOLOGIES NEEDED BY RESEARCH KNOWLEDGE PROVIDERS
BBSRC TECHNOLOGY STRATEGY: TECHNOLOGIES NEEDED BY RESEARCH KNOWLEDGE PROVIDERS 1. The Technology Strategy sets out six areas where technological developments are required to push the frontiers of knowledge
More information200630 - FBIO - Fundations of Bioinformatics
Coordinating unit: Teaching unit: Academic year: Degree: ECTS credits: 2015 200 - FME - School of Mathematics and Statistics 1004 - UB - (ENG)Universitat de Barcelona MASTER'S DEGREE IN STATISTICS AND
More informationTeaching Bioinformatics to Undergraduates
Teaching Bioinformatics to Undergraduates http://www.med.nyu.edu/rcr/asm Stuart M. Brown Research Computing, NYU School of Medicine I. What is Bioinformatics? II. Challenges of teaching bioinformatics
More informationIntegrating Bioinformatics, Medical Sciences and Drug Discovery
Integrating Bioinformatics, Medical Sciences and Drug Discovery M. Madan Babu Centre for Biotechnology, Anna University, Chennai - 600025 phone: 44-4332179 :: email: madanm1@rediffmail.com Bioinformatics
More informationREGULATIONS FOR THE DEGREE OF BACHELOR OF SCIENCE IN BIOINFORMATICS (BSc[BioInf])
820 REGULATIONS FOR THE DEGREE OF BACHELOR OF SCIENCE IN BIOINFORMATICS (BSc[BioInf]) (See also General Regulations) BMS1 Admission to the Degree To be eligible for admission to the degree of Bachelor
More informationPh.D. in Bioinformatics and Computational Biology Degree Requirements
Ph.D. in Bioinformatics and Computational Biology Degree Requirements Credits Students pursuing the doctoral degree in BCB must complete a minimum of 90 credits of relevant work beyond the bachelor s degree;
More informationAn Interdepartmental Ph.D. Program in Computational Biology and Bioinformatics:
An Interdepartmental Ph.D. Program in Computational Biology and Bioinformatics: The Yale Perspective Mark Gerstein, Ph.D. 1,2, Dov Greenbaum 1, Kei Cheung, Ph.D. 3,4,5, Perry L. Miller, M.D., Ph.D. 3,4,6
More informationBIO 3350: ELEMENTS OF BIOINFORMATICS PARTIALLY ONLINE SYLLABUS
BIO 3350: ELEMENTS OF BIOINFORMATICS PARTIALLY ONLINE SYLLABUS NEW YORK CITY COLLEGE OF TECHNOLOGY The City University Of New York School of Arts and Sciences Biological Sciences Department Course title:
More informationRapid alignment methods: FASTA and BLAST. p The biological problem p Search strategies p FASTA p BLAST
Rapid alignment methods: FASTA and BLAST p The biological problem p Search strategies p FASTA p BLAST 257 BLAST: Basic Local Alignment Search Tool p BLAST (Altschul et al., 1990) and its variants are some
More informationS1 Text. Modeling deterministic single-cell microrna-p53-mdm2 network Figure 2 Figure 2
S1 Text. Modeling deterministic single-cell microrna-p53-mdm2 network The schematic diagram of the microrna-p53-mdm2 oscillator is illustrated in Figure 2. The interaction scheme among the mrnas and the
More informationBiochemistry. Entrance Requirements. Requirements for Honours Programs. 148 Bishop s University 2015/2016
148 Bishop s University 2015/2016 Biochemistry The Biochemistry program at Bishop s is coordinated through an interdisciplinary committee of chemists, biochemists and biologists, providing students with
More informationData Integration. Lectures 16 & 17. ECS289A, WQ03, Filkov
Data Integration Lectures 16 & 17 Lectures Outline Goals for Data Integration Homogeneous data integration time series data (Filkov et al. 2002) Heterogeneous data integration microarray + sequence microarray
More informationHow many of you have checked out the web site on protein-dna interactions?
How many of you have checked out the web site on protein-dna interactions? Example of an approximately 40,000 probe spotted oligo microarray with enlarged inset to show detail. Find and be ready to discuss
More informationIntegrating DNA Motif Discovery and Genome-Wide Expression Analysis. Erin M. Conlon
Integrating DNA Motif Discovery and Genome-Wide Expression Analysis Department of Mathematics and Statistics University of Massachusetts Amherst Statistics in Functional Genomics Workshop Ascona, Switzerland
More informationFART Neural Network based Probabilistic Motif Discovery in Unaligned Biological Sequences
FART Neural Network based Probabilistic Motif Discovery in Unaligned Biological Sequences M. Hemalatha, P. Ranjit Jeba Thangaiah and K. Vivekanandan, Member IEEE Abstract Finding Motif in bio-sequences
More informationATIP Avenir Program 2014. Applicant s guide
ATIP Avenir Program 2014 Applicant s guide Important dates: - November 29 th 2013: deadline for the online submission, the mailing of the hard copy of the scientific project, and the letters of recommendation
More informationClusterControl: A Web Interface for Distributing and Monitoring Bioinformatics Applications on a Linux Cluster
Bioinformatics Advance Access published January 29, 2004 ClusterControl: A Web Interface for Distributing and Monitoring Bioinformatics Applications on a Linux Cluster Gernot Stocker, Dietmar Rieder, and
More informationAP Biology Essential Knowledge Student Diagnostic
AP Biology Essential Knowledge Student Diagnostic Background The Essential Knowledge statements provided in the AP Biology Curriculum Framework are scientific claims describing phenomenon occurring in
More informationFACULTY OF MEDICAL SCIENCE
Doctor of Philosophy in Biochemistry FACULTY OF MEDICAL SCIENCE Naresuan University 73 Doctor of Philosophy in Biochemistry The Biochemistry Department at Naresuan University is a leader in lower northern
More informationActivity 7.21 Transcription factors
Purpose To consolidate understanding of protein synthesis. To explain the role of transcription factors and hormones in switching genes on and off. Play the transcription initiation complex game Regulation
More informationBSc (Hons) Biology (Minor: Forensic Science or Marine & Coastal Environmental Science)/MSc Biology SC516 (Subject to Approval) SC516
BSc (Hons) Biology (Minor: Forensic Science or Marine & Coastal Environmental Science)/MSc Biology SC516 (Subject to Approval) SC516 1. Mission, Aims and Objectives The new BSc (Hons)/ MSc course is a
More informationTranscription and Translation of DNA
Transcription and Translation of DNA Genotype our genetic constitution ( makeup) is determined (controlled) by the sequence of bases in its genes Phenotype determined by the proteins synthesised when genes
More informationDr Alexander Henzing
Horizon 2020 Health, Demographic Change & Wellbeing EU funding, research and collaboration opportunities for 2016/17 Innovate UK funding opportunities in omics, bridging health and life sciences Dr Alexander
More informationThe National Institute of Genomic Medicine (INMEGEN) was
Genome is...... the complete set of genetic information contained within all of the chromosomes of an organism. It defines the particular phenotype of an individual. What is Genomics? The study of the
More informationFor additional information on the program, see the current university catalog.
For information call: Tel: (818) 77-81 Fax: (818) 77-08 E-mail: chemistry.office@csun.edu Website: http://www.csun.edu/chemistry Or write: Department of Chemistry and Biochemistry California State University,
More informationBioinformatics: course introduction
Bioinformatics: course introduction Filip Železný Czech Technical University in Prague Faculty of Electrical Engineering Department of Cybernetics Intelligent Data Analysis lab http://ida.felk.cvut.cz
More informationMaster of Philosophy (MPhil) and Doctor of Philosophy (PhD) Programs in Life Science
CURRICULUM FOR RESEARCH POSTGRADUATE PROGRAMS Master of Philosophy (MPhil) and Doctor of Philosophy (PhD) Programs in Life Science Curriculum for Master of Philosophy (MPhil) Program in Life Science The
More informationCourse Curriculum for Master Degree in Medical Laboratory Sciences/Clinical Biochemistry
Course Curriculum for Master Degree in Medical Laboratory Sciences/Clinical Biochemistry The Master Degree in Medical Laboratory Sciences /Clinical Biochemistry, is awarded by the Faculty of Graduate Studies
More informationOrdered Index Seed Algorithm for Intensive DNA Sequence Comparison
Ordered Index Seed Algorithm for Intensive DNA Sequence Comparison Dominique Lavenier IRISA / CNRS Campus de Beaulieu 35042 Rennes, France lavenier@irisa.fr Abstract This paper presents a seed-based algorithm
More informationBiological Sequence Data Formats
Biological Sequence Data Formats Here we present three standard formats in which biological sequence data (DNA, RNA and protein) can be stored and presented. Raw Sequence: Data without description. FASTA
More informationNOVEL GENOME-SCALE CORRELATION BETWEEN DNA REPLICATION AND RNA TRANSCRIPTION DURING THE CELL CYCLE IN YEAST IS PREDICTED BY DATA-DRIVEN MODELS
NOVEL GENOME-SCALE CORRELATION BETWEEN DNA REPLICATION AND RNA TRANSCRIPTION DURING THE CELL CYCLE IN YEAST IS PREDICTED BY DATA-DRIVEN MODELS Orly Alter (a) *, Gene H. Golub (b), Patrick O. Brown (c)
More informationIntro to Bioinformatics
Intro to Bioinformatics Marylyn D Ritchie, PhD Professor, Biochemistry and Molecular Biology Director, Center for Systems Genomics The Pennsylvania State University Sarah A Pendergrass, PhD Research Associate
More informationCALIFORNIA STATE UNIVERSITY CHANNEL ISLANDS
CALIFORNIA STATE UNIVERSITY CHANNEL ISLANDS PROGRAM MODIFICATION DATE: 12.06.06 PROGRAM AREA: BIOLOGY AND BUSINESS AND ECONOMICS SEMESTER /YEAR FIRST EFFECTED: FALL 2007 Please use the following format
More informationFlipFlop: Fast Lasso-based Isoform Prediction as a Flow Problem
FlipFlop: Fast Lasso-based Isoform Prediction as a Flow Problem Elsa Bernard Laurent Jacob Julien Mairal Jean-Philippe Vert September 24, 2013 Abstract FlipFlop implements a fast method for de novo transcript
More informationSearching Nucleotide Databases
Searching Nucleotide Databases 1 When we search a nucleic acid databases, Mascot always performs a 6 frame translation on the fly. That is, 3 reading frames from the forward strand and 3 reading frames
More informationBIOLOGICAL SCIENCES REQUIREMENTS [63 75 UNITS]
Biological Sciences Major The Biological Sciences address many of the most important and fundamental questions about our world: What is life? How does our brain produce our ideas and emotions? What are
More informationSGI. High Throughput Computing (HTC) Wrapper Program for Bioinformatics on SGI ICE and SGI UV Systems. January, 2012. Abstract. Haruna Cofer*, PhD
White Paper SGI High Throughput Computing (HTC) Wrapper Program for Bioinformatics on SGI ICE and SGI UV Systems Haruna Cofer*, PhD January, 2012 Abstract The SGI High Throughput Computing (HTC) Wrapper
More informationDNA and the Cell. Version 2.3. English version. ELLS European Learning Laboratory for the Life Sciences
DNA and the Cell Anastasios Koutsos Alexandra Manaia Julia Willingale-Theune Version 2.3 English version ELLS European Learning Laboratory for the Life Sciences Anastasios Koutsos, Alexandra Manaia and
More informationBIOINF 525 Winter 2016 Foundations of Bioinformatics and Systems Biology http://tinyurl.com/bioinf525-w16
Course Director: Dr. Barry Grant (DCM&B, bjgrant@med.umich.edu) Description: This is a three module course covering (1) Foundations of Bioinformatics, (2) Statistics in Bioinformatics, and (3) Systems
More informationGenetomic Promototypes
Genetomic Promototypes Mirkó Palla and Dana Pe er Department of Mechanical Engineering Clarkson University Potsdam, New York and Department of Genetics Harvard Medical School 77 Avenue Louis Pasteur Boston,
More informationTECHNOLOGIES, PRODUCTS & SERVICES for MOLECULAR DIAGNOSTICS, MDx ABA 298
DIAGNOSTICS BUSINESS ANALYSIS SERIES: TECHNOLOGIES, PRODUCTS & SERVICES for MOLECULAR DIAGNOSTICS, MDx ABA 298 By ADAMS BUSINESS ASSOCIATES MAY 2014. May 2014 ABA 298 1 Technologies, Products & Services
More informationFACULTY OF MEDICAL SCIENCE
Doctor of Philosophy Program in Microbiology FACULTY OF MEDICAL SCIENCE Naresuan University 171 Doctor of Philosophy Program in Microbiology The time is critical now for graduate education and research
More informationAGILENT S BIOINFORMATICS ANALYSIS SOFTWARE
ACCELERATING PROGRESS IS IN OUR GENES AGILENT S BIOINFORMATICS ANALYSIS SOFTWARE GENESPRING GENE EXPRESSION (GX) MASS PROFILER PROFESSIONAL (MPP) PATHWAY ARCHITECT (PA) See Deeper. Reach Further. BIOINFORMATICS
More information13.4 Gene Regulation and Expression
13.4 Gene Regulation and Expression Lesson Objectives Describe gene regulation in prokaryotes. Explain how most eukaryotic genes are regulated. Relate gene regulation to development in multicellular organisms.
More informationMATCH Commun. Math. Comput. Chem. 61 (2009) 781-788
MATCH Communications in Mathematical and in Computer Chemistry MATCH Commun. Math. Comput. Chem. 61 (2009) 781-788 ISSN 0340-6253 Three distances for rapid similarity analysis of DNA sequences Wei Chen,
More informationA Primer of Genome Science THIRD
A Primer of Genome Science THIRD EDITION GREG GIBSON-SPENCER V. MUSE North Carolina State University Sinauer Associates, Inc. Publishers Sunderland, Massachusetts USA Contents Preface xi 1 Genome Projects:
More informationGuidelines for Establishment of Contract Areas Computer Science Department
Guidelines for Establishment of Contract Areas Computer Science Department Current 07/01/07 Statement: The Contract Area is designed to allow a student, in cooperation with a member of the Computer Science
More informationCollege of Pharmacy & Pharmaceutical Sciences Graduate Catalog 2015-2016
College of Pharmacy & Pharmaceutical Sciences Graduate Catalog 2015-2016 Degrees Offered Doctor of Philosophy in Experimental Therapeutics Doctor of Philosophy in Medicinal Chemistry Master of Science
More informationHow To Change Medicine
P4 Medicine: Personalized, Predictive, Preventive, Participatory A Change of View that Changes Everything Leroy E. Hood Institute for Systems Biology David J. Galas Battelle Memorial Institute Version
More informationAnalytical Study of Hexapod mirnas using Phylogenetic Methods
Analytical Study of Hexapod mirnas using Phylogenetic Methods A.K. Mishra and H.Chandrasekharan Unit of Simulation & Informatics, Indian Agricultural Research Institute, New Delhi, India akmishra@iari.res.in,
More informationGraduate and Postdoctoral Affairs School of Biomedical Sciences College of Medicine. Graduate Certificate. Metabolic & Nutritional Medicine
Graduate and Postdoctoral Affairs School of Biomedical Sciences College of Medicine Graduate Certificate in Metabolic & Nutritional Medicine Graduate Certificate Metabolic & Nutritional Medicine Purpose
More informationSCIENCE. Introducing updated Cambridge International AS & A Level syllabuses for. Biology 9700 Chemistry 9701 Physics 9702
Introducing updated Cambridge International AS & A Level syllabuses for SCIENCE Biology 9700 Chemistry 9701 Physics 9702 The revised Cambridge International AS & A Level Biology, Chemistry and Physics
More informationLecture Series 7. From DNA to Protein. Genotype to Phenotype. Reading Assignments. A. Genes and the Synthesis of Polypeptides
Lecture Series 7 From DNA to Protein: Genotype to Phenotype Reading Assignments Read Chapter 7 From DNA to Protein A. Genes and the Synthesis of Polypeptides Genes are made up of DNA and are expressed
More informationDepartment of Microbiology, University of Washington
The Bioverse: An object-oriented genomic database and webserver written in Python Jason McDermott and Ram Samudrala Department of Microbiology, University of Washington mcdermottj@compbio.washington.edu
More informationCurriculum Policy of the Graduate School of Agricultural Science, Graduate Program
Curriculum Policy of the Graduate School of Agricultural Science, Graduate Program Agricultural Science plans to conserve natural and artificial ecosystems and its ideal of "Sustainable coexistence science"
More informationControl of Gene Expression
Control of Gene Expression What is Gene Expression? Gene expression is the process by which informa9on from a gene is used in the synthesis of a func9onal gene product. What is Gene Expression? Figure
More informationMolecular Genetics: Challenges for Statistical Practice. J.K. Lindsey
Molecular Genetics: Challenges for Statistical Practice J.K. Lindsey 1. What is a Microarray? 2. Design Questions 3. Modelling Questions 4. Longitudinal Data 5. Conclusions 1. What is a microarray? A microarray
More informationStructure and Function of DNA
Structure and Function of DNA DNA and RNA Structure DNA and RNA are nucleic acids. They consist of chemical units called nucleotides. The nucleotides are joined by a sugar-phosphate backbone. The four
More informationWhen you install Mascot, it includes a copy of the Swiss-Prot protein database. However, it is almost certain that you and your colleagues will want
1 When you install Mascot, it includes a copy of the Swiss-Prot protein database. However, it is almost certain that you and your colleagues will want to search other databases as well. There are very
More informationFocusing on results not data comprehensive data analysis for targeted next generation sequencing
Focusing on results not data comprehensive data analysis for targeted next generation sequencing Daniel Swan, Jolyon Holdstock, Angela Matchan, Richard Stark, John Shovelton, Duarte Mohla and Simon Hughes
More informationEfficient Parallel Execution of Sequence Similarity Analysis Via Dynamic Load Balancing
Efficient Parallel Execution of Sequence Similarity Analysis Via Dynamic Load Balancing James D. Jackson Philip J. Hatcher Department of Computer Science Kingsbury Hall University of New Hampshire Durham,
More informationUCL courses that require ATAS
UCL courses that require ATAS Faculty of Brain Sciences Division of Psychology and Language Sciences Research Degree: Neuroscience NIMH (4 years) Faculty of Engineering Sciences Biochemical Engineering
More informationUniversity of Glasgow - Programme Structure Summary C1G5-5100 MSc Bioinformatics, Polyomics and Systems Biology
University of Glasgow - Programme Structure Summary C1G5-5100 MSc Bioinformatics, Polyomics and Systems Biology Programme Structure - the MSc outcome will require 180 credits total (full-time only) - 60
More informationTEACHING POSITIONS AVAILABLE IN BIOLOGY UNIVERSITY OF SAN FRANCISCO SPRING 2014
TEACHING POSITIONS AVAILABLE IN BIOLOGY UNIVERSITY OF SAN FRANCISCO SPRING 2014 Positions available (course descriptions and class times attached) Laboratory Instructors: PhDs and graduate students at
More information582606 Introduction to bioinformatics
582606 Introduction to bioinformatics Autumn 2007 Esa Pitkänen Master's Degree Programme in Bioinformatics (MBI) Department of Computer Science, University of Helsinki http://www.cs.helsinki.fi/mbi/courses/07-08/itb/
More informationBiology Institute: 7 PhD programs Expertise in all areas of biological sciences
Biology Institute: 7 PhD programs Expertise in all areas of biological sciences!" #$%&'()*" '+**$,%' Biology Institute: PhD programs Programs Website: http://www.ib.unicamp.br/pos About the Biology Institute
More informationSchool of Nursing. Presented by Yvette Conley, PhD
Presented by Yvette Conley, PhD What we will cover during this webcast: Briefly discuss the approaches introduced in the paper: Genome Sequencing Genome Wide Association Studies Epigenomics Gene Expression
More informationMolecular Biology And Biotechnology
in Molecular Biology And Biotechnology National Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Diliman, Quezon City 1101 National Institute of Molecular
More informationStudy Program Handbook Biochemistry and Cell Biology
Study Program Handbook Biochemistry and Cell Biology Bachelor of Science Jacobs University Undergraduate Handbook BCCB - Matriculation Fall 2015 Page: ii Contents 1 The Biochemistry and Cell Biology (BCCB)
More informationBig Data Healthcare. Fei Wang Associate Professor Department of Computer Science and Engineering School of Engineering University of Connecticut
Big Data Healthcare Fei Wang Associate Professor Department of Computer Science and Engineering School of Engineering University of Connecticut Healthcare Is in Crisis Hersh, W., Jacko, J. A., Greenes,
More informationModule 1. Sequence Formats and Retrieval. Charles Steward
The Open Door Workshop Module 1 Sequence Formats and Retrieval Charles Steward 1 Aims Acquaint you with different file formats and associated annotations. Introduce different nucleotide and protein databases.
More informationControl of Gene Expression
Control of Gene Expression (Learning Objectives) Explain the role of gene expression is differentiation of function of cells which leads to the emergence of different tissues, organs, and organ systems
More informationWeb-Based Genomic Information Integration with Gene Ontology
Web-Based Genomic Information Integration with Gene Ontology Kai Xu 1 IMAGEN group, National ICT Australia, Sydney, Australia, kai.xu@nicta.com.au Abstract. Despite the dramatic growth of online genomic
More informationCore Facility Genomics
Core Facility Genomics versatile genome or transcriptome analyses based on quantifiable highthroughput data ascertainment 1 Topics Collaboration with Harald Binder and Clemens Kreutz Project: Microarray
More informationDoctoral Programs of the HGS Application requirements and deadlines
Doctoral Programs of the HGS Application requirements and deadlines Natural Sciences and Mathematics Fields of study Application requirements Application deadline Comment Berlin Mathematical School Mathematics
More informationAdmission and Advancement through the Biotechnology Certificate Program
Updated: August 19, 2015 Admission and Advancement through the Biotechnology Certificate Program Biotechnology Certificate Program Table of Contents Gaining Admission... 3 Admission Requirements... 3 CSU
More informationK 066/875. Master Curriculum. Bioinformatics. (in English)
K 066/875 Master Curriculum Bioinformatics (in English) 29. Sitzung der CPK, 17.6.2013 Mitteilungsblatt vom 26.06.2013 25. Stk. Pkt. 168 Version IV.5 5_MS_Bioinformatics_Curriculum Seite 1 von 10 Inkrafttreten:
More informationCore Bioinformatics. Degree Type Year Semester. 4313473 Bioinformàtica/Bioinformatics OB 0 1
Core Bioinformatics 2014/2015 Code: 42397 ECTS Credits: 12 Degree Type Year Semester 4313473 Bioinformàtica/Bioinformatics OB 0 1 Contact Name: Sònia Casillas Viladerrams Email: Sonia.Casillas@uab.cat
More informationASBMB. Media Kit INSPIRE H EDUCATE H ADVANCE. Reach Biochemists and Molecular Biologists.
INSPIRE H EDUCATE H ADVANCE 2015 ASBMB Media Kit Reach Biochemists and Molecular Biologists. American Society for Biochemistry and Molecular Biology 11200 Rockville Pike, Suite 302 Rockville, MD 20852-3110
More informationLecture 1 MODULE 3 GENE EXPRESSION AND REGULATION OF GENE EXPRESSION. Professor Bharat Patel Office: Science 2, 2.36 Email: b.patel@griffith.edu.
Lecture 1 MODULE 3 GENE EXPRESSION AND REGULATION OF GENE EXPRESSION Professor Bharat Patel Office: Science 2, 2.36 Email: b.patel@griffith.edu.au What is Gene Expression & Gene Regulation? 1. Gene Expression
More informationRuss College of Engineering and Technology. Revised 9/06. 2. Undergraduate GPA of 3.0/4.0 or equivalent.
Requirements and Guidelines for the Master of Science Degree in Biomedical Engineering Revised 9/06 I. Minimum Entrance Requirements Admission is subject to final approval by the BME Graduate Committee.
More informationNext Generation Sequencing: Technology, Mapping, and Analysis
Next Generation Sequencing: Technology, Mapping, and Analysis Gary Benson Computer Science, Biology, Bioinformatics Boston University gbenson@bu.edu http://tandem.bu.edu/ The Human Genome Project took
More informationA Multiple DNA Sequence Translation Tool Incorporating Web Robot and Intelligent Recommendation Techniques
Proceedings of the 2007 WSEAS International Conference on Computer Engineering and Applications, Gold Coast, Australia, January 17-19, 2007 402 A Multiple DNA Sequence Translation Tool Incorporating Web
More informationTranslation Study Guide
Translation Study Guide This study guide is a written version of the material you have seen presented in the replication unit. In translation, the cell uses the genetic information contained in mrna to
More informationGlobal and Discovery Proteomics Lecture Agenda
Global and Discovery Proteomics Christine A. Jelinek, Ph.D. Johns Hopkins University School of Medicine Department of Pharmacology and Molecular Sciences Middle Atlantic Mass Spectrometry Laboratory Global
More informationIllinois Mathematics and Science Academy
Illinois Mathematics and Science Academy A Pioneering Educational Community Name Ms. O Leary-Driscoll Phone 5363 e-mail soleary@imsa.edu Comprehensive Course Syllabus for Bioinformatics Fall 2015 Instructors
More informationHierarchical Bayesian Modeling of the HIV Response to Therapy
Hierarchical Bayesian Modeling of the HIV Response to Therapy Shane T. Jensen Department of Statistics, The Wharton School, University of Pennsylvania March 23, 2010 Joint Work with Alex Braunstein and
More informationLast Name First Name: Term of graduation Departmental Approval
Biochemistry - Pre-Health Science Track BS Degree Completion Checklist Last Name First Name: _ GT ID #_ Catalog Year Date Term of graduation Departmental Approval _ Total Semester Credit Hours Required
More informationModulhandbuch / Program Catalog. Master s degree Evolution, Ecology and Systematics. (Master of Science, M.Sc.)
Modulhandbuch / Program Catalog Master s degree Evolution, Ecology and Systematics (Master of Science, M.Sc.) (120 ECTS points) Based on the Examination Regulations from March 28, 2012 88/434/---/M0/H/2012
More informationBioinformatics Resources at a Glance
Bioinformatics Resources at a Glance A Note about FASTA Format There are MANY free bioinformatics tools available online. Bioinformaticists have developed a standard format for nucleotide and protein sequences
More informationMolecular Cell Biology WS2011
Molecular Cell Biology WS2011 Lecturer: Dr. Andreas Prokesch, Inst. for Genomics and Bioinformatics, TUG Purpose of this series of lectures: to offer you the basic knowledge required to know and understand
More informationFINDING RELATION BETWEEN AGING AND
FINDING RELATION BETWEEN AGING AND TELOMERE BY APRIORI AND DECISION TREE Jieun Sung 1, Youngshin Joo, and Taeseon Yoon 1 Department of National Science, Hankuk Academy of Foreign Studies, Yong-In, Republic
More informationBachelor of Science in Biochemistry and Molecular Biology
Bachelor of Science in Biochemistry and Molecular Biology Biochemistry is a subject in life sciences whose objective entails understanding the Molecular Basis of life in plants and animals. It is a multi-disciplinary
More information