Issues Relevant to Endocrine Disruptor Screening
|
|
|
- Linette Hutchinson
- 8 years ago
- Views:
Transcription
1 Concepts of Endocrinology: Issues Relevant to Endocrine Disruptor Screening Raphael J. Witorsch, Ph.D. Professor Emeritus Physiology and Biophysics School of Medicine Virginia i i Commonwealth University it Richmond, Virginia raphaelwitorsch@comcast.net 1
2 OBJECTIVES OF PRESENTATION To provide a basic overview of some of the principles of endocrinology. To discuss specific aspects of endocrinology relevant to the assessment of endocrine disruptors (ED) with particular emphasis on issues that may currently be overlooked or underestimated; complicate the results and/or interpretation of ED screening assays or experiments. 2
3 Endocrine System: A mode of communication Endocrine gland A ductless gland whose secretions are released into the extracellular fluid for action at a remote site. Hormone (Gr. to excite or arouse ) The chemical messenger secreted by an endocrine gland. 3
4 Hormones Synthesized and Secreted by Traditional Endocrine Glands (protein/peptide, modified amino acid, steroid) Gland Hypothalamus Pituitary Thyroid Parathyroid Pancreas Hormone releasing and inhibiting hormones: GnRH, TRH, CRH, somatostatin, PIH (dopamine) anterior growth hormone, prolactin, ACTH, TSH, FSH, LH posterior ADH, oxytocin thyroxine (T4), triiodothyronine (T3), calcitonin parathyroid hormone (PTH) insulin, glucagon, somatostatin Adrenal cortex cortisol, aldosterone, and DHEA medulla epinephrine, norepinephrine Ovary Testes estradiol 17β, progesterone, inhibin testosterone, inhibin 4
5 Receptors: How a target cell recognizes a hormone 5
6 Hypothalamo-Pituitary Target Organ Systems 6
7 Endocrine Disruption Effect of chemicals on endocrine function 7
8 Sites Where Endocrine Disruptors Can Act Hormone receptor Hormone secretion Hormone bioavailability, and clearance Feedback control 8
9 In vitro EDSP Tier 1 Battery of Screening Assays ER binding g( (rat uterine cytosol) her transcriptional activation (ERTA) (HeLa cells) AR binding (rat prostate cytosol) In vivo Uterotrophic (rat, sc, ovex, uterine wt.) Hershberger (rat, oral, orchidex, peripubertal, sex organ wts) Pubertal female (rat, oral, time of vaginal opening, TSH, T4, etc.) Pubertal male (rat, oral, preputial separation, TSH, T4, etc.) Steroidogenesis H295R (human adrenocortical tumor) Aromatase (human recombinant microsomes) Amphibian metamorphosis (tadpole to frog, thyroid histology) Fish short-term reproduction (male, female fathead minnows, morphological and biochemical i endpoints) 9
10 Other Assays Relevant to Endocrine Disruptor Assessment Multigeneration studies In utero effects on offspring 10
11 Receptor Binding Does Not Predict The Nature of a Biological Effect 11
12 Diversity of Biological Effects of ER Ligands mitogenic ER ligand Mammary Uterus Bone gland mitogenic mitogenic antiosteoporotic antimitogenic antiosteoporotic antimitogenic antimitogenic antiosteoporotic 12
13 ER Mechanism of Action 13
14 Factors Contributing to Diversity of Response of Estrogen Receptor Ligands Heterogeneity of ER subtypes (ER, ER ) Ligand specific alterations in ER conformation Heterogeneity of co-regulatory proteins Heterogeneity of ER binding sites within the genome (estrogen response elements) Alternate (non-genomic) pathways ER signaling g may cross-talk with other pathways (e.g., aryl hydrocarbon) 14
15 Species Differences May Be Important 15
16 Endocrinology of Pregnancy: Murine vs. Human (Witorsch,RJ, Food and Chemical Toxicology 40: , 2002) Endpoint Murine Human Dominance of Throughout First trimester corpus luteum gestation (luteal-placental shift) Adrenal DHEA as No Yes estrogen precursor Estrogens produced Estradiol, estrone Estradiol, estrone, estriol Relative bioavailable estrogen 1 <100 16
17 Human vs. Murine Gestation Basic physiological differences Role of corpus luteum Pathways of estrogen production Types of estrogens produced Levels of bioavailable estrogen (<100-fold higher in humans) In utero species differences suggest that humans might be resistant to adverse effects of environmental estrogens observed in murines. 17
18 Stress, A Potential Confounder in Endocrine Disruptor Assessment Secretory Patterns of ACTH and Glucocorticoid Basal (diurnal or circadian): Recurring increase followed by a decrease every 24 hrs as a function of subject s activity pattern. Stress-induced: Abrupt or prolonged increase in response to homeostatic disruption (or stressor ). 18
19 Effects of Stress or Glucocorticoid Excess on Reproduction and Development Testicular dysfunction impaired testosterone production and Leydig cell apoptosis Ovarian hypofunction, amenorrhea, and infertility in women and comparable effects in animals a multistage effect on the hypothalamopituitary-ovarian axis. Fetotoxic effects and post-partum programming Cooke, Holsberger, Witorsch et al., Toxicology and Applied Pharmacology 194: ,
20 Effects of Stress or GC Excess In Utero on Offspring Intrauterine growth retardation (IUGR) Suppression of testosterone surge from fetal testes Postnatal endocrine/reproductive and other effects (programming) Insulin resistance and hypertension Feminization of sexually dimorphic areas of hypothalamus of male offspring Behavioral changes (decreased copulatory behavior of adult males) Decreased anogenital distance, delayed d or abnormal testicular descent and decreased testicular weight in male offspring 20
21 How Stress Can Confound Endocrine Disruptor Assessment Effects attributable to endocrine disruptive chemicals (EDCs) might be due to direct effects of stress-induced elevation of glucocorticoids. Putative EDC might evoke a nonspecific stress response activating the hypothalamo- pituitary-adrenocortical (HPA) axis. Putative EDC might activate element of HPA axis. Procedures performed during an assay (e.g. oral gavage, restraint) might activate HPA axis. Activation of HPA can produce false positive 21 or false negative effects.
22 Summary and Conclusions A brief overview of the essentials of endocrine physiology was presented. Endocrine disruption was discussed d with regard to the following considerations: Diversity of biological effects produced by ER ligands; Species differences (murine vs. human gestation); The influence of stress (glucocorticoids) on reproductive function and development of offspring. The above are important considerations in screening for endocrine disruptors. 22
23 Thank You 23
regulation of ECF composition and volume regulation of metabolism thyroid hormones, epinephrine, growth hormone, insulin and glucagon
Hormonal Effects regulation of ECF composition and volume ADH, aldosterone, ANF regulation of metabolism thyroid hormones, epinephrine, growth hormone, insulin and glucagon regulation of muscle contraction
INTRODUCTION TO HORMONES
INTRODUCTION TO HORMONES UNIVERSITY OF PNG SCHOOL OF MEDICINE AND HEALTH SCIENCES DISCIPLINE OF BIOCHEMISTRY & MOLECULAR BIOLOGY PBL MBBS II SEMINAR VJ Temple What are hormones? Cells in multi-cellular
Chapter 45: Hormones and the Endocrine System
Name Period Overview 1. What is a hormone? 2. Why does a hormone elicit a response only with target cells? 3. The body has two long-distance regulating systems. Which involves chemical signals by hormones?
Endocrine System Review Graphics are used with permission of: Pearson Education Inc., publishing as Benjamin Cummings (http://www.aw-bc.
Endocrine System Review Graphics are used with permission of: Pearson Education Inc., publishing as Benjamin Cummings (http://www.aw-bc.com) Page 1. Endocrine System Review Consists of discrete individual
The Endocrine System
Essentials of Human Anatomy & Physiology Elaine N. Marieb Seventh Edition Chapter 9 The Endocrine System Slides 9.1 9.48 Lecture Slides in PowerPoint by Jerry L. Cook The Endocrine System Second messenger
Ch16 Endocrine part 2
Ch16 Endocrine part 2 several separate organs release hormones into capillaries hormones are transported in the blood Hypothalamus Pituitary glands Pineal gland Thyroid Parathyroid Thymus Adrenal Cortex
Endocrine Glands and the General Principles of Hormone Action
Endocrine Glands and the General Principles of Hormone Action Cai Li, Ph.D. Assistant professor Touchstone Center for Diabetes Research Departments of Physiology and Internal Medicine The University of
Endocrine System ANS 215 Physiology and Anatomy of Domesticated Animals
Endocrine System ANS 215 Physiology and Anatomy of Domesticated Animals I. Introduction A. Considered to be part of animals communication system 1. Nervous system uses physical structures for communication
Hormonal Cycles. 1. Briefly describe each component of an endocrine feedback loop: Stimulus. Production Cell. Hormone. Target Cell. Target Cell Action
Hormonal Cycles Directions: a. Click the Contents button. b. Open the Endocrine System File. c. Click Animations. d. Click Hormonal Cycles. 1. Briefly describe each component of an endocrine feedback loop:
Chapter 18. An Introduction to the Endocrine System. Hormone Chemistry
Chapter 18 An Introduction to the Endocrine System Hormone Chemistry Endocrine System Components endocrine system - glands, tissues, and cells that secrete hormones Copyright The McGraw-Hill Companies,
Endocrinology of the Female Reproductive Axis
Endocrinology of the Female Reproductive Axis girlontheriver.com Geralyn Lambert-Messerlian, PhD, FACB Professor Women and Infants Hospital Alpert Medical School at Brown University Women & Infants BROWN
Endocrine Responses to Resistance Exercise
chapter 3 Endocrine Responses to Resistance Exercise Chapter Objectives Understand basic concepts of endocrinology. Explain the physiological roles of anabolic hormones. Describe hormonal responses to
Hormones: Classification. Hormones: Classification. Peptide Hormone Synthesis, Packaging, and Release
Hormones: Classification Hormones: Classification Be able to give types and example. Compare synthesis, half-life and location of receptor 1. Peptide or protein hormones Insulin from amino acids 2. Steroid
Hormones & Chemical Signaling
Hormones & Chemical Signaling Part 2 modulation of signal pathways and hormone classification & function How are these pathways controlled? Receptors are proteins! Subject to Specificity of binding Competition
Response to Stress Graphics are used with permission of: Pearson Education Inc., publishing as Benjamin Cummings (http://www.aw-bc.
Response to Stress Graphics are used with permission of: Pearson Education Inc., publishing as Benjamin Cummings (http://www.aw-bc.com) Page 1. Introduction When there is an overwhelming threat to the
Endocrine issues in FA SUSAN R. ROSE CINCINNATI CHILDREN S HOSPITAL MEDICAL CENTER
Endocrine issues in FA SUSAN R. ROSE CINCINNATI CHILDREN S HOSPITAL MEDICAL CENTER 80% of children and adults with FA have an endocrine abnormality Endocrine cells make a hormone (message) Carried in bloodstream
Age Management Panel Male Fasting Panel
801 SW 16th St Suite 126 Renton WA 98057 Phone: 425.271.8689 Fax: 425.271.8689 CLIA # 50D0630590 Age Management Panel Male Fasting Panel Doctor ID 1001 Age 55 Date Collected 01/01/07 Patient Name DOE,
glucose and fatty acids to raise your blood sugar levels.
Endocrine & Cell Communication Part IV: Maintaining Balance (Homeostasis) TEACHER NOTES needs coding 1 Endocrine & Cell Communication Part IV: Maintaining Balance (Homeostasis) 2 AP Biology Curriculum
Shira Miller, M.D. Los Angeles, CA 310-734-8864 www.shiramillermd.com. The Compounding Pharmacy of Beverly Hills Beverly Hills Public Library
Shira Miller, M.D. Los Angeles, CA 310-734-8864 The Compounding Pharmacy of Beverly Hills Beverly Hills Public Library 2 Outline What is hormone therapy? Why would healthy men and women need to think about
The Menstrual Cycle. Model 1: Ovarian Cycle follicular cells
The Menstrual Cycle REVIEW questions to complete before starting this POGIL activity 1. Gonads produce both gametes and sex steroid hormones. For the female, name the: A. gonads ovaries B. gametes oocyte/ovum/egg
Mechanism of hormone action
Mechanism of hormone action ผศ.ดร.พญ.ส ว ฒณ ค ปต ว ฒ ภาคว ชาสร รว ทยา คณะแพทยศาสตร ศ ร ราชพยาบาล Aims What is hormone receptor Type of hormone receptors - cell surface receptor - intracellular receptor
The tissues and organs of the vertebrate body cooperate
56 The Endocrine System Concept Outline 56.1 Regulation is often accomplished by chemical messengers. Types of Regulatory Molecules. Regulatory molecules may function as neurotransmitters, hormones, or
Introduction to Animal Systems
Human Body Systems Introduction to Animal Systems Recurring Themes in Biology 1. Correlation between structure and function( seen at many levels) 2. Life is organized at many levels from Smallest ----
Describe how these hormones exert control quickly by changes in phosphorylation state of enzyme, and more slowly by changes of gene expression
Section VIII. Section VIII. Tissue metabolism Many tissues carry out specialized functions: Ch. 43 look at different hormones affect metabolism of fuels, especially counter-insulin Ch. 44 Proteins and
From Menses to Menopause: How Hormones Can Affect Blood Glucose Levels. Christine Day, RN, MS, CNS-BC Lake Superior College
From Menses to Menopause: How Hormones Can Affect Blood Glucose Levels Christine Day, RN, MS, CNS-BC Lake Superior College Overview Will review hormonal changes over the female lifespan Discuss the effects
Common Endocrine Disorders. Gary L. Horowitz, MD Beth Israel Deaconess Medical Center Boston, MA
Common Endocrine Disorders Gary L. Horowitz, MD Beth Israel Deaconess Medical Center Boston, MA Objectives Describe the typical laboratory values for TSH and Free T4 in hypo- and hyperthyroidism Explain
Smoking and Age of Menopause. Women who smoke experience menopause an average of 2 years earlier than women who do not smoke.
Menopause Menopause Feared event To many, it indicates old age - a sign of life coming to a close. Many expect a difficult psychological adjustment to menopause (bad press, bad jokes). Menopause Effect
Chapter 18: The Endocrine System
Chapter 18: The Endocrine System I. Intercellular Communication, p. 591 Objectives 1. Explain the importance of intercellular communication and describe the mechanisms involved. 2. Compare the modes of
The Endocrine System. Dr. Ali Ebneshahidi. Copyright 2006 Pearson Education, Inc., publishing as Benjamin Cummings
The Endocrine System Dr. Ali Ebneshahidi Endocrine System The endocrine system interacts with the nervous system to coordinate and integrate body activities by means of hormones. Endocrine tissues and
Testosterone for women, who when and how much?
Medicine, Nursing and Health Sciences Testosterone for women, who when and how much? Susan R Davis MBBS FRACP PhD Women s Health Research Program School of Public Health Monash University Melbourne Medicine,
Functional Medicine University s Functional Diagnostic Medicine Training Program INSIDER S GUIDE
Functional Medicine University s Functional Diagnostic Medicine Training Program INSIDER S GUIDE Interpretation and treatment: male hormone profile By Ron Grisanti, D.C. & Dicken Weatherby, N.D. http://www.functionalmedicineuniversity.com
Intercellular Communication 1. Direct communication: occurs between two cells of the same type through gap junctions via ions or small solutes
Endocrine System (Chapter 18) Lecture Materials for Amy Warenda Czura, Ph.D. Suffolk County Community College Primary Sources for figures and content: Eastern Campus Marieb, E. N. Human Anatomy & Physiology
Guidelines for Ordering Serum Levels of Gonadotropins (FSH, LH) and Prolactin CLP 021 Revised June, 2008 (Replaces October 2000 version)
Guidelines for Ordering Serum Levels of Gonadotropins (FSH, LH) and Prolactin CLP 021 Revised June, 2008 (Replaces October 2000 version) 1. Scope This laboratory Guideline is intended to assist community
Chapter 45. Hormones and the Endocrine System
Chapter 45 Hormones and the Endocrine System Lecture Outline Overview: The Body s Long-Distance Regulators An animal hormone is a chemical signal that is secreted into the extracellular fluid, circulates
Age and Fertility. A Guide for Patients PATIENT INFORMATION SERIES
Age and Fertility A Guide for Patients PATIENT INFORMATION SERIES Published by the American Society for Reproductive Medicine under the direction of the Patient Education Committee and the Publications
In Vivo and In Vitro Screening for Thyroid Hormone Disruptors
In Vivo and In Vitro Screening for Thyroid Hormone Disruptors Kevin M. Crofton National lhealth and Environmental Research Laboratory California Environmental Protection Agency Human Health Hazard Indicators
FACT SHEET TESTETROL, A NOVEL ORALLY BIOACTIVE ANDROGEN
FACT SHEET TESTETROL, A NOVEL ORALLY BIOACTIVE ANDROGEN General Pantarhei Bioscience B.V. is an emerging specialty pharmaceutical company with a creative approach towards drug development. The Company
Discuss the function of parathyroid hormone.
The Endocrine System 10 C H A P T E R John F. Kennedy, the youngest man to be elected president, appeared healthy, vigorous, and active throughout his entire political career. Photos of the president showed
The Background for the Diabetes Detection Model
The Background for the Diabetes Detection Model James K. Peterson Department of Biological Sciences and Department of Mathematical Sciences Clemson University November 23, 2014 Outline The Background for
The Endocrine System. You don t have to watch CSI to experience action-packed drama.
The Endocrine System: An Overview (pp. 595 596) Hormones (pp. 596 601) The Chemistry of Hormones (p. 596) Mechanisms of Hormone Action (pp. 596 598) Target Cell Specificity (p. 598) Half-Life, Onset, and
Regulation of Metabolism. By Dr. Carmen Rexach Physiology Mt San Antonio College
Regulation of Metabolism By Dr. Carmen Rexach Physiology Mt San Antonio College Energy Constant need in living cells Measured in kcal carbohydrates and proteins = 4kcal/g Fats = 9kcal/g Most diets are
Sex Hormone Testing by Mass Spectrometry
Sex Hormone Testing by Mass Spectrometry Robert L. Fitzgerald, PhD, DABCC Professor of Pathology University of California-San Diego San Diego, CA, 92161 rfitzgerald@ucsd.edu Learning Objectives After this
PSK171 STRESS MANAGEMENT
PSK171 STRESS MANAGEMENT Chapter 2 Systems that control stress arousal Controlling Stress & Tension Girdano, Dusek & Everly Ligands Ligands (amino acid molecules) Biochemicals that carry information Neurohormones
PUBERTY. Dr. Valérie M. Schwitzgebel. Division of Pediatric Endocrinology and Diabetology Hôpital des Enfants HUG Genève Valerie.Schwitzgebel@hcuge.
PUBERTY Dr. Valérie M. Schwitzgebel Division of Pediatric Endocrinology and Diabetology Hôpital des Enfants HUG Genève Valerie.Schwitzgebel@hcuge.ch V. Schwitzgebel 2004 PHYSIOLOGY of PUBERTY DEFINITION
How To Know If You Can Lose Weight
ATTACHMENT: Useful remarks for patient and doctor, to be associated to the analytical results. Your doctor should interpret this report. Cod. ID: 123456 CCV: 000 Date: 01/01/2014 Patient: Rossi Mario Rapport
Pituitary disease for GPs. Dr Tricia Tan Metabolic Medicine and Endocrinology
Pituitary disease for GPs Dr Tricia Tan Metabolic Medicine and Endocrinology Hypothalamo-pituitary-endocrine organ axis Interface between brain and endocrine organs Amplification from Releasing factor
Stress Psychophysiology. Introduction. The Brain. Chapter 2
Stress Psychophysiology Chapter 2 Introduction This chapter covers the process & structures activated during the physiological response to stress. Two stress pathways are available; one for short term
Reproduction and its Hormonal Control
Reproduction and its Hormonal Control Page 1 Reproduction and its Hormonal Control Different mammals have different patterns of reproduction Eg mammals, rats and mice can breed all year round, whereas
INSULIN RESISTANCE, POLYCYSTIC OVARIAN SYNDROME
1 University of Papua New Guinea School of Medicine and Health Sciences Division of Basic Medical Sciences Discipline of Biochemistry and Molecular Biology PBL SEMINAR INSULIN RESISTANCE, POLYCYSTIC OVARIAN
Anatomy and Physiology of Human Reproduction. Module 10a
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike License. Your use of this material constitutes acceptance of that license and the conditions of use of materials on this
endocrino logica Advance Abstracts of Papers Supplementum 225 XII Acta Endocrinologica Congress Munich June 26-30,1979 PERIODICA COPENHAGEN 1979
endocrino logica Supplementum 225 Advance Abstracts of Papers XII Acta Endocrinologica Congress Munich June 26-30,1979 PERIODICA COPENHAGEN 1979 Eigentum der München GENERAL CONTENTS Contents in detail
LAB 12 ENDOCRINE II. Due next lab: Lab Exam 3 covers labs 11 and 12, endocrine chart and endocrine case studies (1-4 and 7).
111 LAB 12 ENDOCRINE II Assignments: Quiz : Endocrine Chart pages 112-114 Due next lab: Lab Exam 3 covers labs 11 and 12, endocrine chart and endocrine case studies (1-4 and 7). Objectives: Review the
10/26/2014. Human Anatomy & Physiology. The Endocrine System: Part A. Endocrine System: Overview
PowerPoint Lecture Slides prepared by Barbara Heard, Human Anatomy & Physiology Atlantic Cape Community College Ninth Edition C H A P T E R 16 The Endocrine System: Part A Endocrine System: Overview Acts
Multiple Pituitary Hormone Deficiency (MPHD)
Multiple Pituitary Hormone Deficiency (MPHD) SERIES 1 SERIES 2 SERIES 3 SERIES 4 SERIES 5 SERIES 6 SERIES 7 SERIES 8 SERIES 9 SERIES 10 SERIES 11 SERIES 12 SERIES 13 SERIES 14 SERIES 15 SERIES 16 CHILD
Stress & Catecholamines - Overview
Stress & Catecholamines - Overview UNIVERSITY OF PNG SCHOOL OF MEDICINE AND HEALTH SCIENCES DISCIPLINE OF BIOCHEMISTRY AND MOLECULAR BIOLOGY PBL MBBS YEAR II SEMINAR VJ Temple Stress can due to: What is
Introduction to the Hypothalamo- Pituitary-Adrenal (HPA) Axis
Igor Mitrovic, MD Introduction to the Hypothalamo- Pituitary-Adrenal (HPA) Axis (Lecture) OBJECTIVES: Identify appropriate hypothalamic factors that control the secretion of each of the anterior pituitary
Hormonal Oral Contraceptives: An Overview By Kelsie Court. A variety of methods of contraception are currently available, giving men and
Hormonal Oral Contraceptives: An Overview By Kelsie Court A variety of methods of contraception are currently available, giving men and women plenty of options in choosing a method suitable to his or her
Hormonal regulation of gonad function overview
Hormonal regulation of gonad function overview Role of hormones in reproductive functions production and maintenance of mature gametes optimization of the circumstances of impregnation support of pregnancy,
Page 1. 1. The production of monoploid cells by spermatogenesis occurs in (1) zygotes (3) ovaries (2) testes (4) meristems
1. The production of monoploid cells by spermatogenesis occurs in (1) zygotes (3) ovaries (2) testes (4) meristems Base your answers to questions 2 and 3 on the diagram below of the female reproductive
Endocrinology. Values & S.I. Unit Conversion Tables
Endocrinology Expected Values & S.I. Unit Conversion Tables Disclaimer: This data applies to the highly sensitive and specific assay methods developed, validated, and performed solely at Endocrine Sciences.
Unit 3 REPRODUCTIVE SYSTEMS AND THE MENSTRUAL CYCLE
Unit 3 REPRODUCTIVE SYSTEMS AND THE MENSTRUAL CYCLE Learning Objectives By the end of this unit, the learner should be able to: Explain the importance of understanding the male and female reproductive
Endocrine System: Practice Questions #1
Endocrine System: Practice Questions #1 1. Removing part of gland D would most likely result in A. a decrease in the secretions of other glands B. a decrease in the blood calcium level C. an increase in
(Received 12th June 1968)
PLASMA LEVELS OF TESTOSTERONE IN MALE RABBITS FOLLOWING COPULATION GARY C. HALTMEYER and KRISTEN B. EIK-NES Department of Physiology, Division of Physiology and Biochemistry of Reproduction, University
Understanding Hormone Excess and Deficiency
Understanding Hormone Excess and Deficiency The comments provided here are for educational purposes only. They should not be interpreted as being diagnostic or treatment recommendations. Those decisions
MENOPAUSE WOMAN'S TEST (Assessment of hormone balance)
ATTACHMENT: Useful remarks for patient and doctor, to be associated to the analytical results. Your doctor should interpret this report. Cod. ID: 123456 CCV: 6bf Date: 01/01/2013 Patient: Rossi Mario Rapport
Blood Testing Protocols. Disclaimer
Blood Testing Protocols / Page 2 Blood Testing Protocols Here are the specific test protocols recommend by Dr. J.E. Williams. You may request these from your doctor or visit www.readyourbloodtest.com to
TSH. TSH is an integral part of a thyroid panel useful for the determination and potential differentiation of hypothyroidism.
TSH Background Thyroid hormone synthesis and secretion is regulated via a negative feed-back control system, which involves the hypothalamus, anterior pituitary, and the thyroid gland. Thyrotrophin-releasing
EHP Student Edition, January 2006, p. A671 A677 http://ehp.niehs.nih.gov/docs/2005/113-10/focus-abs.html
ehp LESSON: Are EDCs Blurring Issues of Summary: Gender? Students read the article Are EDCs Blurring Issues of Gender? and identify and summarize the research cited within the article. Students then decide
Reproduction Multiple Choice questions
Reproduction Multiple Choice questions 1. In mammals that are seasonal breeders, females are receptive only once a year. This is called A) a follicular cycle B) an estrous cycle C) a menstrual cycle D)
OUTCOMES BASED LEARNING MATRIX
OUTCOMES BASED LEARNING MATRIX Course: BIOL 206 Vertebrate Anatomy and Physiology II Department: Biology Course Description: This is the second part of an introductory course sequence in the comparative
Alcohol s Effects on Male Reproduction. Mary Ann Emanuele, M.D., and Nicholas V. Emanuele, M.D.
Alcohol s Effects on Male Reproduction Mary Ann Emanuele, M.D., and Nicholas V. Emanuele, M.D. The male reproductive system consists of the hypothalamus, the anterior pituitary gland, and the testes. Alcohol
Anatomy of the Male Reproductive System
Anatomy of the Male Reproductive System External genitalia (can be seen on the body surface) penis scrotum Internal genitalia (can t be seen on the body surface) sperm producing organs testes ducts that
TECHNICAL INSIGHTS TECHNOLOGY ALERT
TECHNICAL INSIGHTS TECHNOLOGY ALERT UNLOCKING BREAST CANCER TUMORS' DRUG RESISTANCE A troubling phenomenon in breast cancer treatment is that some patients tumors become resistant to treatments over time.
Women & Men s Health
ChiroCredit.com/OnlineCE.com Presents: Intro To Hormones 102 Salivary Hormone Testing Part 2 Women & Men s Health Ronald Steriti, ND, PhD 2008 Salivary Hormones The following hormones are typically in
The ABC s and T s of Male Infertility
The ABC s and T s of Male Infertility Men s Health Initiative of BC - Focus on Testosterone Ethan D. Grober, MD, MEd, FRCSC Assistant Professor University of Toronto Department of Surgery, Division of
COLLIN COLLEGE COURSE SYLLABUS
COLLIN COLLEGE COURSE SYLLABUS Course Information Course Number: BIOL 2402 Course Title: Anatomy and Physiology II Course Description: Continued study of structure and function related to the human endocrine,
Hormone Replacement Therapy For Women
Hormone Replacement Therapy For Women Bio-identical Hormone Replacement Therapy Gail Eberharter M.D. May 10, 2009 There are three main hormones that are responsible for the menstrual cycle, sexual drive
DiNP Dose-Response Studies:
DiNP Dose-Response Studies: Gestation PK and Developmental Effects Postnatal Effects Final Project Summary October 2011 Rebecca Clewell, PhD Research Investigator Institute for Chemical Safety Sciences
Immunoassay. Product Portfolio. www.diametra.com info@diametra.com Part of the IDS group
Immunoassay Portfolio www.diametra.com info@diametra.com Part of the IDS group Bringing Value-Added Efficiency To Your Laboratory Diametra is dedicated to providing quality products and the highest level
Urinary System. And Adrenal Function
Urinary System And Adrenal Function Overview Kidney anatomy and physiology Urine Ureters, Bladder and Urethra Adrenal Function Functions of the Kidney Filter fluids from the blood Regulate volume and composition
Testosterone Therapy for Women
Testosterone Therapy for Women The Facts You Need Contents 2 INTRODUCTION: The Facts You Need... 3-4 CHAPTER 1: Testosterone and Women... 5-9 CHAPTER 2: Testosterone Therapy for Women... 10-14 CONCLUSION:
Anatomy of the Male Reproductive System
Anatomy of the Male Reproductive System Anatomy of the Male Reproductive System External genitalia (can be seen on the body surface) penis scrotum Internal genitalia (can t be seen on the body surface)
Subject Index. Bariatric surgery, obesity management 134
Subject Index Acromegaly, PCOS differential diagnosis 149, 150, 154, 155 Adipokines, see specific adipokines Adiponectin, metabolic syndrome role 41 43 Adolescents, PCOS diagnosis 16, 17 Adrenal hyperplasia,
Calcium. Table 1: Difference between method means in percent
Calcium Measurement of total calcium is widely used for both the diagnosis and the monitoring of a range of conditions related to the bones, heart, nerves, and kidneys. Total calcium measurements include
Reproductive System & Development: Practice Questions #1
Reproductive System & Development: Practice Questions #1 1. Which two glands in the diagram produce gametes? A. glands A and B B. glands B and E C. glands C and F D. glands E and F 2. Base your answer
Part C. Hazard Assessment and Review of Available Studies
Part C Hazard Assessment and Review of Available Studies List of Contents 10. Possible Effects of Atrazine Exposure on Testosterone Metabolism... 3 11. Epidemiology... 4 11.1 IUGR in Iowa Communities...
How To Understand The Hypothalamus
883 Hypothalamus HYPOTHALAMUS Introduction The hypothalamus is a very small, but extremely important part of the diencephalon that is involved in the mediation of endocrine, autonomic and behavioral functions.
The Endocrine System
The Endocrine System from The Human Body Systems Series catalog # 3254 Published & Distributed by AGC/UNITED LEARNING 1560 Sherman Avenue Suite 100 Evanston, IL 60201 1-800-323-9084 24-Hour Fax No. 847-328-6706
FERTILITY AND AGE. Introduction. Fertility in the later 30's and 40's. Am I fertile?
FERTILITY AND AGE Introduction Delaying pregnancy is a common choice for women in today's society. The number of women in their late 30s and 40s attempting pregnancy and having babies has increased in
and Evaluation of the Dan Lukaczer ND
Adrenal Dysfunction and Evaluation of the Adrenal Stress Profiles Dan Lukaczer ND Inside the Presentation If you have a technical issue, type your question in this box and select send to : Host, then click
DOES OSTEOPATHIC TREATMENT INFLUENCE THE HORMONE LEVEL OF HYPERANDROGENAEMIC INFERTILE WOMEN? Sabine Heim A-6850 Dornbirn
DOES OSTEOPATHIC TREATMENT INFLUENCE THE HORMONE LEVEL OF HYPERANDROGENAEMIC INFERTILE WOMEN? By Sabine Heim A-6850 Dornbirn Part of requirement for M.Sc. (Osteopathy) Donau-Universität Krems Abteilung
Integration and Coordination of the Human Body. Nervous System
I. General Info Integration and Coordination of the Human Body A. Both the and system are responsible for maintaining 1. Homeostasis is the process by which organisms keep internal conditions despite changes
Physiology of Pregnancy. Maternal Physiology Fetal Physiology First Trimester Second Trimester Third Trimester Birth Labor and Parturition Lactation
Physiology of Pregnancy Maternal Physiology Fetal Physiology First Trimester Second Trimester Third Trimester Birth Labor and Parturition Lactation Maternal Physiology Basal metabolic rate increases 15%
Biology [SBI 4U] FINAL EXAMINATION
![Biology [SBI 4U] FINAL EXAMINATION](/thumbs/27/12196629.jpg "Biology [SBI 4U] FINAL EXAMINATION")
Biology [SBI 4U] FINAL EXAMINATION Date: November 28, 2012 (Wednesday) Time: 8:30 a.m. 10:30 a.m. Length: 2 hours Lecturer: Ms. Kimberley Gagnon Canadian International Matriculation Programme Student Name:
Testosterone. Testosterone For Women
Testosterone Testosterone is a steroid hormone. Popular use of the term steroid leads people to believe that it signifies a drug that s illegal and abused by some body builders and other athletes. While
Male Health. The three major issues are: Cardiovascular Health Prostate Health Fertility & Sexual Performance
Male Health Do Men Value Their Health? The ancient Greek physician Hippocrates once said, A wise man ought to realise that his health is his most valuable possession. It is believed that Hippocrates lived
THYROID FUNCTION TESTS
Thyroid Stimulating Hormone (TSH): THYROID FUNCTION TESTS The thyroid stimulating hormone (TSH) assay measures the concentration of thyroid stimulating hormone in the serum. TSH assays have been classified
INTRODUCTION TO REPRODUCTIVE HEALTH AND THE ENVIRONMENT (Draft for review)
TRAINING FOR THE HEALTH SECTOR [Date Place Event Sponsor Organizer] INTRODUCTION TO REPRODUCTIVE HEALTH AND THE ENVIRONMENT (Draft for review) November 2011 Training Module 1 Children's Environmental Health
Beyond the Basics of Endocrine Stimulation Testing Las Vegas, NV. Conflict of Interest Disclosure 4/17/2013
Beyond the Basics of Endocrine Stimulation Testing Las Vegas, NV Earline Edwards MSN, APRN NP, CPNP, CDE University of NE Medical Center Children s Hospital Omaha, NE Conflict of Interest Disclosure Advisory
Testosterone and androgens in women
Testosterone and androgens in women http://womenshealth.med.monash.edu.au 1. Women normally produce testosterone 2. Changes in testosterone over the normal menstrual cycle 3. Changes in testosterone with