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1 Can a protein your of interest? help find Can mirna be easier to find? Can you take the mess out of Western Can sample prep be faster? Can you take the mess Can mirna be easier to blotting? Can media bottles be built to store? Is there an easier way to build interest? Can mirna be easier to find? Can you take the mess search engine efficient? a cdna library? Can RNAi manufacturing be more protein of your earch engine help find Find answers, enhanced search, protocols, application notes, and theeasiestorderingontheweb.allatinvitrogen.com/questionus 2008 Invitrogen Corporation. All rights reserved.

2 cell sciences Cytokine Center Browse our web site with over 1300 proteins, including recombinant cytokines, growth factors, chemokines and neurotrophins. Daily shipping and competitive pricing are offered. Bulk quantities of many proteins available. PROTEINS 4-1BBL 4-1BB Receptor 6 Ckine ACAD8 ACAT2 gacrp30/adipolean Activin A Activin B ACY1 ADAT1 Adiponectin ADRP AITRL Akt1 Alpha-Feto Protein (AFP) Alpha-Galactosidase A Angiopoietin-1 (Ang-1) Angiopoietin-2 (Ang-2) Angiostatin K1-3 Annexin-V apo-saa Apoliprotein A-1 Apoliprotein E2 Apoliprotein E3 Apoliprotein E4 APRIL Artemin ATF2 Aurora A Aurora B BAFF BAFF Receptor BCA-1 / BLC / CXCL13 BCMA BD-1 BD-2 BD-3 BDNF Betacellulin Bivalirudin BMP-2 BMP-4 BMP-6 BMP-7 BMP-13 sbmpr-1a Brain Natriuretic Protein BRAK Breast Tumor Antigen C5a C5L2 Peptide C-10 C-Reactive Protein C-Src Calbindin D-9K Calbindin D-28K Calbindin D-29K Calmodulin Calcitonin Acetate Carbonic Anhydrase III Carcino-embryonic Antigen Cardiotrophin-1 Caspase-3 Caspase-6 CD4 CD14 CD22 CD40 Ligand / TRAP CD95 / sfas Ligand CD105 / Endoglin CHIPS CNTF Collagen CREB CTACK / CCL27 CTGF CTGFL / WISP-2 CTLA-4 / Fc CXCL16 CYR61 Cytokeratin 8 DEP-1 Desmopressin Disulfide Oxidoreductase E-selectin ECGF EGF Elafin / SKALP EMAP-II ENA-78 / CXCL5 Endostatin Enteropeptidase Eotaxin / CCL11 Eotaxin-2 Eotaxin-3 (TSC) EPHB2 EPHB4 Epigen Epiregulin Eptifbatide Erk-2 Erythropoietin (EPO) Exodus-2 Fas Ligand Fas Receptor FGF-1 (acidic) FGF-2 (basic) FGF-4 FGF-5 FGF-6 FGF-7 / KGF FGF-8 FGF-9 FGF-10 FGF-16 FGF-17 FGF-18 FGF-19 FGF-20 sfgfr-1 (IIIc) / Fc Chimera sfgfr-2 (IIIc) / Fc Chimera sfgfr-3 / Fc Chimera sfgfr-4 / Fc Chimera sflt-1 (native) sflt-1 (D3) sflt-1 (D4) sflt-1 (D5) sflt-1 (D7) Flt3-Ligand sflt-4 sflt-4 / Fc Chimera Follistatin FSH Fractalkine / CX3C G-CSF α-galactosidase A Galectin-1 Galectin-3 Gastrointestinal CA GCP-2 GDF-3 GDF-9 GDF-11 GDNF GLP-1 Glucagon GM-CSF Goserelin GPBB Granzyme B GROα GROβ GROγ GRO/MGSA Growth Hormone Growth Hormone BP GST-p21/WAF-1 HB-EGF HCC-1 HGF Histdyl-tRNA synthetase Histrelin HRG1-β1 I-309 I-TAC IFN-α IFN-α A IFN-α 2a IFN-α 2b IFN-β IFN-γ IFN-Omega IGF-I IGF-II proigf-ii IGFBP-1 IGFBP-2 IGFBP-3 IGFBP-4 IGFBP-5 IGFBP-6 IGFBP-7 IL-1α IL-1β IL-2 IL-3 IL-4 sil-4 Receptor IL-5 IL-6 sil-6 Receptor IL-7 IL-8 (72 a.a.) IL-8 (77 a.a.) IL-9 IL-10 IL-11 IL-12 IL-13 IL-13 analog IL-15 IL-16 (121 a.a.) IL-16 (130 a.a.) IL-17 IL-17B IL-17D IL-17E IL-17F IL-19 IL-20 IL-21 IL-22 IL-31 Insulin IP-10 JE JNK2a1 JNK2a2 KC / CXCL1 KGF L-asparaginase LAG-1 LALF Peptide LAR-PTP LBP LC-1 LD-78β LDH LEC / NCC-4 Leptin LIGHT LIX LKM LL-37 Lungkine / CXCL15 Lymphotactin slyve-1 M-CSF MCP-1 (MCAF) MCP-2 MCP-3 MCP-4 MCP-5 MDC (67 a.a.) MDC (69 a.a.) MDH MEC Mek-1 MIA Midkine MIG / CXCL9 MIP-1α / CCL3 MIP-1β / CCL4 MIP-3 / CCL23 MIP-3α / CCL20 MIP-3β / CCL19 MIP-4 (PARC) / CCL18 MIP-5 / CCL15 MMP-3 MMP-7 MMP-13 Myostatin Nanog NAP-2 Neurturin NFAT-1 β-ngf NOGGIN NOV NP-1 NT-1/BCSF-3 NT-3 NT-4 Ocreotide Oncostatin M Osteoprotegerin (OPG) OTOR Oxytocin p38-α PAI-1 Parathyroid Hormone PDGF-AA PDGF-AB PDGF-BB PDGF-CC Persephin PF-4 PIGF-1 PIGF-2 PKA α-subunit PKC-α PKC-γ Pleiotrophin PLGF-1 Polymyxin B (PMB) PRAS40 PRL-1 PRL-2 PRL-3 Prokineticin-2 Prolactin Protirelin PTHrP PTP1B PTP-IA2 PTP-MEG2 PTP-PEST srank srankl RANTES RELM-α RELM-β Resistin RPTPβ RPTPγ RPTPμ SCF SCGF-α SCGF-β SDF-1α SDF-1β Secretin SF20 SHP-2 STAT1 c-src TACI TARC TC-PTP TECK TFF2 TGF-α TGF-β1 TGF-β2 TGF-β3 Thymosin α1 stie-1/fc Chimera stie-2/fc Chimera TL-1A TNF-α TNF-β stnf-receptor Type I stnf-receptor Type II TPO strail R-1 (DR4) strail R-2 (DR5) TRAIL/Apo2L TSG TSH TSLP TWEAK TWEAK Receptor Urokinase EG-VEGF VEGF121 VEGF145 VEGF165 VEGF-C VEGF-C I125 VEGF-E HB-VEGF-E svegfr-1 svegfr-2 svegfr-3 Visfatin WISP-1 WISP-2 WISP-3 WNT Neponset Street, Building 12A, Canton, MA TEL (781) info@cellsciences.com CALL TOLL FREE (888) FAX (781) VISIT

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4 Sample technologies by QIAGEN Prepare for results Rely on QIAGEN sample technologies for: DNA, RNA, and protein purification Automated sample preparation Whole genome and transcriptome amplification Epigenetics sample preparation SampleTech0608S1WW Sample collection and stabilization Contact QIAGEN today or visit Sample & Assay Technologies

5 Personal Automation TM Accelerates Research The NEW Flexi Method Firmware provides you flexibility to modify Maxwell 16. You re in control to create, save and run your own automated methods. The new Maxwell 16 Flexi Method Firmware enables you to modify, create, save and run your own automated methods for purification of DNA, RNA or recombinant proteins. It s automation at the bench that processes up to 16 samples. It gives you the flexibility and control to optimize your success. To get yourself more flexibility and control visit: Promega Corporation, AD-IN

6 Save 15% in October! Ina K. Dahlsveen, Ph.D. Start your microrna discovery from a single cell WiththenewmiRCURYLNA micrornapcrsystem, yourdiscoverystartsfrom10pgtotalrna youonly needasinglecell.youcanevendetectmicrornaswith highandlowexpressionfromthesamesampleinyour experiment,asthedynamicrangeis8logswide. Our PCR system combines microrna-specific primers and SYBR Green detection and is part of Exiqon s popular mircurylna productline,themostcompleterangeof tools for microrna analysis available today. Ina K. Dahlsveen, Ph.D., Product Manager Get the complete mircury LNA System now and save 15%! Visit exiqon.com/pcr15 Accurate quantitation over a wide dynamic range of microrna copy numbers Fluorescence Cycle number x 10 9 copies 2 copies Cycle number microrna R 2 = Amplification efficiency 100% Amplification of a synthetic microrna was performed using the mircury LNA microrna PCR System. Hsa-miR-100 ( copies) input was used to generate cdna. A ten-fold serial dilution ranging from copies to 2 copies cdna was amplified by real-time PCR. A. The amplification curves and B. the standard curve show excellent linear correlation between the decreasing cycle numbers and the logarithm of the microrna copy number, proving the assay enables sensitive microrna detection down to less than 10 copies with a wide dynamic range of at least 8 logs. A B d NOTICE TO PURCHASER: LIMITED LICENSE. Purchase of this product includes an immunity from suit under patents specified in the product insert to use only the amount purchased for the purchaser s own internal research. No other patent rights are conveyed expressly, by implication, or by estoppel. Further information on purchasing licenses may be obtained by contacting the Director of Licensing, Applied Biosystems, 850 Lincoln Centre Drive, Foster City, California 94404, USA. SYBR Green is a trademark of Invitrogen Offer only valid in October 2008

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8 Length Matters Genome Sequencer FLX DNA Sequencing Flowgram: Each bar within the flowgram represents a discrete nucleotide (A, T, C, or G) and the height of the bar corresponds to the number of nucleotides detected. Although the majority of sequencing reads are between 400 to 500 bases, the above flowgram represents a sequencing read of 543 bases. For life science research only. Not for use in diagnostic procedures. 454, 454 LIFE SCIENCES, 454 SEQUENCING, and GS FLX TITANIUM are trademarks of Roche. Other brands or product names are trademarks of their respective holders Roche Diagnostics GmbH. All rights reserved.

9 Introducing the GS FLX Titanium Reagents Obtain sequencing read lengths of 400 to 500 bases. Generate more than 1 million sequencing reads per 10-hour instrument run. Learn more at Roche Diagnostics GmbH Roche Applied Science Mannheim, Germany

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12 TaKaRa Ex Taq Do it Right the First Time PCR that Works! Takara s robust, sensitive enzymes yield superior results on templates of varying sizes. Ex Taq produces excellent amplification of fragments from 0.5 kb to 20 kb. Takara offers a wide selection of PCR enzymes for most popular applications. High Fidelity PCR PrimeSTAR HS DNA Polymerase for 10X higher fidelity than Taq as well as extended lengths up to 20 kb. Real Time PCR SYBR Premix Ex Taq (Perfect Real Time) for sensitive qpcr detection using SYBR Green I. SYBR Premix Ex Taq II (Perfect Real Time) for improved reaction specificity and performance. Premix Ex Taq (Perfect Real Time) for specific qpcr using probe detection. All three premixes are compatible with a variety of real-time PCR instruments. Multiplex PCR Taq Hot Start DNA Polymerase for excellent sensitivity and reproducibility in multiplex PCR. LA Taq HS DNA Polymerase for challenging multiplex PCR. High-Speed PCR SpeedSTAR Hot Start DNA Polymerase for high speed, high sensitivity PCR. Hot-Start PCR Ex Taq HS DNA Polymerase for increased sensitivity and high yield. Taq HS DNA Polymerase for increased specificity and reduced background. LA Taq HS DNA Polymerase for long PCR. Long PCR PCR PRODUCTS LA Taq DNA Polymerase for superior amplification of long and GC-rich templates. PrimeSTAR, SpeedSTAR, TaKaRa Ex Taq and TaKaRa LA Taq are trademarks of Takara Bio Inc. LA PCR technology is covered by U.S. Patent No. 5,436,149 issued to Takara Bio Inc. Purchase of this product includes an immunity from suit under patents specified in the product insert to use only the amount purchased for the purchaser s own internal research. No other patent rights (such as 5 Nuclease Process patent rights) are conveyed expressly, by implication, or by estoppel. Further information on purchasing licenses may be obtained by contacting the Director of Licensing, Applied Biosystems, 850 Lincoln Centre Drive, Foster City, California 94404, USA. Takara Bio s Hot Start PCR related products are licensed under U.S. patent 5,338,671 and 5,587,287 and corresponding patents in other countries. SYBR is a registered trademark Molecular Probes. Visit our Website Today! Japan: Takara Bio Inc USA: Takara Bio USA A Division of Clontech Laboratories, Inc Europe: Takara Bio Europe S.A.S China: Takara Biotechnology (Dalian) Co., Ltd Korea: Takara Korea Biomedical Inc

13 EppendorfConsumables it syoursample eppendorf is a registered trademark. All rights reserved, including graphics and images. Make the best of it! Top quality for your sample. Each single of your valuable samples deserves the best treatment. See for yourself how Eppendorf Consumables will save time and reduce costs. Sample loss can be time consuming and expensive. Therefore,theimmediateenvironmentofthesample should be adapted to its specific quality and purity needs. Thiscaninvolveaspecificpuritylevelortheabsenceof certain substances, but also stability, reliability or geometry. Eppendorf consumables are designed to cover all of the specific needs of your sample! Bring out the best! Eppendorf Deepwell Plates: l 30% faster and easier well identification with the unique OptiTrack Matrix l High dimensional stability for efficient centrifugation and mixing l MinimizedsamplelosswithDNAorProteinLoBind quality and RecoverMax well design Learn more about Eppendorf Deepwell Plates: Your local distributor Application Support support@eppendorf.com Eppendorf AG Hamburg Germany Tel: Eppendorf North America, Inc. USA Tel.:

14 Picture yourself as a AAAS Science & Technology Policy Fellow Make a Difference. Help give science a greater voice in Washington, DC! Since 1973, AAAS Fellows have applied their skills to federal decisionmaking processes that affect people in the U.S. and around the world, while learning first-hand about the government and policymaking. Join the Network. Year-long fellowships are available in the U.S. Congress and federal agencies. Applicants must hold a PhD or equivalent doctoral-level degree in any behavioral/social, biological, medical/health, or physical science, or any engineering discipline. Individuals with a master s degree in engineering and three years of postdegree professional experience also may apply. Federal employees are not eligible and U.S. citizenship is required. Enhancing Public Policy, Advancing Science Careers James Fleming, PhD History of Science, Princeton University AAAS Roger Revelle Fellow in Global Stewardship, serving as a public policy scholar at the Woodrow Wilson International Center for Scholars. Recently returned to Colby College, where he serves as professor of Science, Technology, and Society. Apply. The application deadline for the AAAS Fellowships is 15 December Fellowships are awarded in the spring and begin in September. Stipends range from $68,000 to $90,000. Note: Additional fellowships are available through approximately 30 scientific society partners. Individuals are encouraged to apply with AAAS as well as with any scientific societies for which they qualify. Full details at: fellowships.aaas.org

15 January 2009 Epigenetics, Development, and Human Disease, Breckenridge, CO Angiogenesis and Lymphangiogenesis in Cancer, Big Sky, MT Mobilizing Cellular Immunity for Cancer Therapy, Snowbird, UT The Many Faces of Ubiquitin, Copper Mountain, CO Plant Sensing, Response, and Adaptation to the Environment, Big Sky, MT Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota, Taos, NM Mechanotransduction in Physiology and Disease, Taos, NM Allergy and Asthma, Keystone, CO* Fibrosis, Keystone, CO* Type 2 Diabetes and Insulin Resistance, Banff, AB* Obesity: Novel Aspects of the Regulation of Body Weight, Banff, AB* Multiple Sclerosis, Santa Fe, NM Emerging Tumor Suppressors, Taos, NM Omics Meets Cell Biology, Breckenridge, CO Tuberculosis: Biology, Pathology, and Therapy, Keystone, CO February 2009 Pathogenesis and Immune Regulation in Helminth Infections, Tahoe City, CA Frontiers in Reproductive Biology and Regulation of Fertility, Santa Fe, NM TH17 Cells in Health and Disease, Vancouver, BC Immunologic Memory and Host Defense, Keystone, CO Therapeutic Modulation of RNA Using Oligonucleotides, Lake Louise, AB Frontiers of NMR in Biology, Santa Fe, NM Neurodegenerative Diseases: New Molecular Mechanisms, Keystone, CO* Axonal Connections: Molecular Cues for Development and Regeneration, Keystone, CO* Imaging and Drug Development, Copper Mountain, CO The Neurobiology of Pain and Analgesia, Santa Fe, NM B Cells in Context, Taos, NM Complications of Diabetes and Obesity, Vancouver, BC* Dissecting the Vasculature: Function, Molecular Mechanisms, and Malfunction, Vancouver, BC* Chromatin Dynamics and Higher Order Organization, Coeur d Alene, ID March 2009 (continued) Epigenetic Basis of Neurodevelopmental Disorders, Keystone, CO* Chemical Senses: Receptors and Circuits, Tahoe City, CA Extrinsic Control of Tumor Genesis and Progression, Vancouver, BC Cardiac Disease: Development, Regeneration, and Repair, Asheville, NC Drug Discovery for Protozoan Parasites, Breckenridge, CO Prevention of HIV/AIDS, Keystone, CO* HIV Immunobiology: From Infection to Immune Control, Keystone, CO* Cell Death Pathways, Whistler, BC* Mitochondrial Dynamics and Physiology, Whistler, BC* Antibodies as Drugs, Whistler, BC* Targeted Cancer Therapies, Whistler, BC* Pattern Recognition Molecules and Immune Sensors of Pathogens, Banff, AB* Dendritic Cells, Banff, AB* April 2009 Common Mechanisms in Arrhythmias and Heart Failure, Keystone, CO The Future of Biofuels, Snowbird, UT Stem Cell Niche Interactions, Whistler, BC PI 3-Kinase Signaling in Disease, Olympic Valley, CA* Complex Lipids in Biology: Signaling, Compartmentalization, and Disease, Olympic Valley, CA* The Biology of RNA Silencing, Victoria, BC May 2009 Human Immunology and Immunodeficiencies, Beijing, China June 2009 Protein Dynamics, Allostery, and Function, Keystone, CO MicroRNA and Cancer, Keystone, CO Deregulation of Transcription in Cancer, Killarney, Ireland October 2009 Telomere Biology and DNA Repair, Ashmore, Queensland, Australia March 2009 Regulatory T Cells, Keystone, CO Genome Instability and DNA Repair, Taos, NM The Molecular Basis of Schizophrenia and Bipolar Disorder, Keystone, CO* Keystone Symposia on Molecular and Cellular Biology is a nonprofit organization headquartered in Colorado, USA that is directed and supported by the scientific community

16 LIFE AAAS/Science SCIENCE Business Office Feature TECHNOLOGIES New Products Focus: PCR/RT-PCR LIFE SCIENCE AAAS/Science TECHNOLOGIES Business Office Feature Applied Biosystems For information MicroRNA Products The TaqMan MicroRNA MegaPlex products consist of three new molecular tools designed to streamline the workflow for microrna (mirna) analysis, address the needs of researchers working with minuteamountsofrna,andprovidebroad,up-to-datecoverageof knownmirnasexpressedinbiologicalsamplesfromhumans,mice, and rats. The Megaplex RT Primers consist of high-complexity pools of novel stem-looped reverse transcriptase (RT) primers that reduce the number of RT reactions needed to profile mirna expression. The MegaPlex PreAmp Primers enable preamplification of starting RNA material when sensitivity is of the utmost importance. Incorporation of preamplification reduces the total RNA input needed to perform an analysis to as little as one nanogram. The TaqMan MicroRNA Arrays are microfluidics cards containing TaqMan MicroRNA Assays that enable rapid and reproducible generation of real-time PCR data for hundreds of mirna targets in parallel. PCR Boosting Reagent PCRboost is a reagent that enhances end-point and reverse-transcription polymerase chain reaction (PCR) fivefold or more during amplification of genomic DNA or RNA templates. It can improve amplification of challenging samples, including trace or degraded samples, long fragments, and low-copy transcripts. PCRboost requires no changes to the user s PCR protocol, but can simply be used to replace the water in the reaction. Biomatrica For information Pipetting Tips Polymerase chain reaction and Sterile CyBi-TipsTrays are available for all purity specifications for use with bacteria and cell cultures as well as nucleic acids. CyBio guarantees precise results at the highest stage. The pipetting tips were designed and developed with great care according to precise specifications to ensure consistent high quality. CyBio For information Electronic Dispensers The electronic Repeater stream and Xstream hand dispensers are designed for accelerating processes and saving time on long-series pipetting. When used with Combitips Plus tips, the Repeater stream is suitable for all standard pipetting and dispensing applications, while the Repeater Xstream can also perform titrations, sequential dispensing, and aspiration of supernatants. The instruments increased volume selection provides the flexibility needed for research as well as routine tasks. Their smooth handling reduces the fatigue associated with repetitive work. The nine sizes of Combitips Plus allow a wide dispensing range of up to 112 different volumes. The large volumes allow longer series dispensing without stopping for a refill. Eppendorf For information Genomic DNA The OmniPrep kit isolates high-quality genomic DNA from many different species and tissue types, including animal, plant, bacteria, yeast, fungi, whole blood, and cells in culture. DNA can be isolated from samples high in polysaccharides or other contaminants difficult to remove from the preparations. The kit features a rapid precipitation technique with unique reagents that isolate genomic DNA free from proteins and RNA. Genomic DNA can be isolated in 20 to 40 minutes, depending on the tissue sample type used. The resulting genomic DNA is visualized on an agarose gel as a large single band, demonstrating the high quality and minimal shearing of the technique. G-Biosciences/Genotech For information Gene Expression Arrays The Roche NimbleGen Sequence Capture 385K Custom Arrays save time and money compared with polymerase chain reaction methods by capturing up to 5Mb of targeted regions from full complexity genomic DNA. Captured fragments are well suited for high throughput sequencing on instruments such as the 454 Genome Sequencer FLX system. The Capture Arrays incorporate built-in control probes and can be tailored to capture target genomic regions or thousands of exons in parallel. The NimbleGen HD2 12-plex arrays for gene expression analysis enable the user to hybridize 12 independent samples on a single slide. These multiplex arrays offer a cost-effective approach to gene expression analysis, without compromising information content or data quality. These arrays are available in a broad range of whole-genome designs or can be custom designed for experimental goals and genomes of interest. Roche Nimblegen For information Electronically submit your new product description or product literature information! Go to for more information. Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier OCTOBER 2008 VOL 322 SCIENCE

17 The McGill University Life Sciences Complex heralds a bold new era in life sciences research, where leading investigators in diverse fields will pioneer new frontiers in biomedicine. Together, the Faculties of Medicine and Science will uncover the biological basis of disease and translate research breakthroughs into novel treatments and cures. This is McGill s platform to accelerate the pace of discovery and help fulfill its mission of providing outstanding knowledge and service to society in Quebec, in Canada and around the world. This project was made possible through the generous support of Dr.FrancescoBellini,RosalindandMorrisGoodman,theGovernment of Quebec, the Canada Foundation for Innovation and many other McGill alumni and friends. McGill University Life Sciences Complex

18 Unlimited! With Sigma, the potential is infinite! Unlock the unlimited potential of your research with Sigmas GenomePlex Whole Genome Amplification family of products. Robust and accurate amplification - abundant DNA yields in less than 4 hours with no detectable allele or locus bias. Maximum flexibility - amplify DNA from any source including purified genomic DNA, single cells, formalin-fixed paraffin-embedded (FFPE) tissues, blood, buccal swabs, plants and bacteria. Unlimited genetic analysis - GenomePlex DNA is suitable for use with numerous downstream applications including QPCR, Comparative Genomic Hybridization (CGH), Microarrays, STR and SNP analysis. To discover the unlimited potential of your research visit: sigma.com/wga Our Innovation, Your Research Shaping the Future of Life Science GenomePlex is a registered trademark of Rubicon Genomics. sigma-aldrich.com