Laurence L. Miller, Ph.D. Assistant Professor Department of Psychological Sciences Georgia Regents University Augusta 2500 Walton Way, Augusta, GA 30904 706-729-2451 (Office) 706-434-3200 (Fax) LauMiller@GRU.edu Education and Postdoctoral Training 2010-2014 Department of Pharmacology and Toxicology Virginia Commonwealth University School of Medicine Research Focus: Modulation of brain reward function by pathological states Mentor: S. Stevens Negus, Ph.D. 2010 Ph.D Psychology, Behavioral Neuroscience Concentration University of North Carolina at Chapel Hill Dissertation: Cannabinoid Modulation of the Behavioral Effects of Morphine Mentor: Linda A. Dykstra, Ph.D. 2005 M.A. Psychology, Experimental Psychology Concentration University of North Carolina Wilmington Thesis: A Competitive NMDA Receptor Antagonist Potentiates the Effects of Morphine on Spatial And Discrimination Learning Mentor: Mark Galizio, Ph.D. 2000 B.A. Psychology University of North Carolina Wilmington Extramural Funding F32-DA033920 Miller, PI 2012-2013 National Institute on Drug Abuse Functional Consequences of HIV-1 Tat on Motivated Behavior Major Goal: To evaluate the functional consequences and mechanisms of HIV-Tat associated neurodegeneration. F31-DA025446 Miller, PI 2009-2010 National Institutes on Drug Abuse Morphine/Cannabinoid Interactions: antinociception, tolerance and sensitization Major Goal: To evaluate compounds that increase endogenous cannabinoid activity as modulators of opioid effects in the treatment of pain-related behaviors. 1
Teaching and Mentorship Georgia Regents University Augusta Miller, Laurence L 2014 Graduate Research Practicum Mentor, Department of Psychological Sciences 2014 Course Director, Department of Psychological Sciences Psychology 3122: Research Methods 2014 Course Director, Department of Psychological Sciences Psychology 4990: Undergraduate Research 2014 Guest Lecturer, Department of Psychological Sciences Psychology 6930: Graduate Research Practicum Virginia Commonwealth University 2013 Lecturer, Department of Pharmacology and Toxicology Pharmacology and Toxicology 691: Special Topics in Pharmacology: ICSS as an Experimental Tool in Behavioral Pharmacology 2011 Lecturer, Department of Pharmacology and Toxicology Pharmacology and Toxicology 691: Special Topics in Pharmacology: Neurobiology of Pain and Analgesia University of North Carolina at Chapel Hill 2009 Course Director, Department of Psychology Psychology 222: Learning (Fall) 2009 Course Director, Department of Psychology Psychology 222: Learning (Spring) 2009-2010 Mentor, Department of Psychology Michael Umberger, Psychology major at UNC at Chapel Hill Undergraduate Directed Indepednent Study: Operant Response Rate- Decreasing Effects of Cannabinoids and Opioids 2008 Teaching Assistant, Department of Psychology Psychology 222: Learning University of North Carolina at Wilmington 2003 Teaching Assistant, Department of Psychology Introduction to Psychology 2003 Teaching Assistant, Department of Psychology Research Methods 2
Departmental and Institutional Service Georgia Regents University Augusta 2014 Graduate Curriculum Committee Department of Psychological Sciences 2014 Security Committee College of Science and Mathematics Virginia Commonwealth University 2012/2013 Coordinator, NIDA Institutional Training Grant Seminar Series Department of Pharmacology and Toxicology Academic and Professional Honors 2014 Virginia Commonwealth University Dept. of Pharmacology and Toxicology Outstanding Postdoctoral Fellow 2012-2013 NIDA F32 Postdoctoral Trainee 2012 Cold Spring Harbor Laboratories Cellular Biology of Addiction Scholarship 2010-2012 NIDA T32 Postdoctoral Trainee 2009-2010 NIDA F31 Predoctoral Trainee 2007 NIDA Director s Travel Award, College on Problems of Drug Dependence 2006 NIDA Director s Travel Award, College on Problems of Drug Dependence 2005-2008 NIDA T32 Predoctoral Trainee Professional Service Ad hoc Reviewer: Psychopharmacology Pharmacological Research Behavioural Pharmacology Drug and Alcohol Dependence Professional Memberships American Pain Society American Society for Pharmacology and Experimental Therapeutics APA Division 28: Psychopharmacology and Substance Abuse College on Problems of Drug Dependence International Cannabinoid Research Society Society for Neuroscience Southeastern Association for Behavior Analysis 3
Publications Miller, Laurence L Miller, L.L., Leitl, M.D., Banks, M.L., Blough, B.E. and Negus, S.S. (in press). Effects of the triple monoamine uptake inhibitor amitifadine on pain-depressed behavior and nucleus accumbens dopamine release in rats. Pain Negus, S.S. and Miller, L.L. (2014). Intracranial self-stimulation to evaluate abuse potential of drugs. Pharmacological Reviews 66: 869-917. ** Altarifi, A.A., Miller, L.L., and Negus, S.S. (2012). Role of µ-opioid receptor reserve and µ-agonist efficacy on µ-agonist effects on intracranial self-stimulation. Behavioural Pharmacology. Behavioural Pharmacology 23: 678-692. ** Atarifi, A.A and Miller, L.L. contributed equally to this work Miller, L.L., Picker, M.J., Umberger, M.D., Schmidt, K.T., and Dykstra, L.A. (2012). Effects of alterations in cannabinoid signaling, alone and in combination with morphine on painelicited and pain-suppressed behavior in mice. The Journal of Pharmacology and Experimental Therapeutics 342: 177-187. Picker, M.J., Daugherty, D., Henry, F.E., Miller, L.L., and Dykstra, L.A. (2011). Metabotropic glutamate antagonists alone and in combination with morphine: Comparison across two models of acute pain and a model of persistent inflammatory pain. Behavioural Pharmacology 22: 785-793. Dykstra, L.A., Fischer, B.D., Balter, R.B., Henry, F.E., Schmidt, K.T., and Miller, L.L. (2011). Opioid antinociception, tolerance and dependence: Interactions with the N-methyl- D-aspartate (NMDA) system in mice. Behavioural Pharmacology 22: 540-547. Miller, L.L., Schmidt, K.T., Picker, M.J., and Dykstra, L.A. (2011). Effects of morphine in CB1 receptor knockout mice: pain-elicited versus pain-suppressed behaviors. Psychopharmacology 215: 455-465. Miller, L.L., Ward, S.J., and Dykstra, L.A. (2008). Chronic unpredictable stress enhances cocaine conditioned place preference in CB1 receptor knockout mice. Behavioural Pharmacology 19:575-581. Fischer, B.D., Miller, L.L., Henry, F.E., Picker, M.J., and Dykstra, L.A. (2008). Increased efficacy of mu-opioid agonist-induced antinociception by metabotropic glutamate receptor antagonists in C57BL/6 mice: comparison with (-)-6-phosphonomethyl-decahydroisoquinoline-3-carboxylic acid (LY235959). Psychopharmacology 198:271-278. Galizio, M., Miller, L.L., Ferguson, A., McKinney, P., and Pitts, R.C. (2006). Olfactory repeated discrimination reversal in rats: effects of chlordiazepoxide, dizocilpine, and morphine. Behavioural Neuroscience 120:1175-1179. 4
Abstracts and Presentations: Miller, L.L., Altarifi, A.A. and Negus, S.S. (2014). Effects of Repeated Morphine on Intracranial Self-Stimulation in Rats in the Absence or Presence of a Noxious Pain Stimulus. Poster presented at the Annual Meeting of the South Eastern Association of Behavior Analysis, Wilmington, NC October 2014. Miller, L.L., Leitl, M.D., Banks, M.L., Blough, B.E. and Negus, S.S. (2014). Pain-related Depression of Behavior: Involvement of the Mesolimbic Dopamine System and Effects of Monoamine Uptake Inhibitors. Invited talk presented at the 13 th Annual World Pharma Congress in the conference: Pain: Novel Drug Targets and Screening Tools, Boston, MA May 2014. Miller, L.L., Leitl, M.D., Blough, B.E., and Negus, S.S. (2013). Effects of the triple monoamine uptake inhibitor amitifadine on pain-stimulated and pain-depressed behavior in rats. Poster presented at the Annual Meeting of the Society for Neuroscience, San Diego, CA November, 2013. Miller, L.L., and Negus, S.S. (2012). Pharmacological determinants of abuse-related morphine effects in an assay of intracranial self-stimulation in rats. Poster presented at the Annual Meeting of the Society for Neuroscience, New Orleans, LA October, 2012. Miller, L.L., and Dykstra, L.A. (2011). Enhancement of morphine s effects on painsuppressed wheel-running by a FAAH inhibitor. Poster presented at the College on Problems of Drug Dependence: Hollywood, Florida, 2011. Miller, L.L., Schmidt, K.T., Umberger, M.D., Picker, M.J. and Dykstra, L.A. (2010). The Fatty acid amide hydrolase inhibitor, URB597, morphine, and the CB1 agonist, CP55940 in assays of pain-elicited, pain-suppressed, and schedule-controlled behavior. Poster presented at the College on Problems of Drug Dependence: Scottsdale, Arizona, 2010. Miller, L.L., Picker, M.J. Schmidt, K.T., and Dykstra, L.A. (2009). Pain-elicited and suppressed behaviors in CB1 knockout mice and their wild-type littermates: effects of morphine. Poster presented at the College on Problems of Drug Dependence: Reno, Nevada, 2009. Daugherty, D.E., Miller, L.L., Picker, M.J. and Dykstra, L.A. (2009). Morphine antinociception in combination with metabotropic glutamate receptor (MGLUR) antagonists. Oral communication presented at the College on Problems of Drug Dependence: Reno, Nevada, 2009. Culmer, T.L., Miller, L.L., and Dykstra, L.A. (2009). Forced swim test and the endogenous cannabinoid receptor system: effects of an anandamide reuptake inhibitor and a fatty acid amide hydrolase metabolism inhibitor. Oral communication presented at the College on Problems of Drug Dependence: Reno, Nevada, 2009. 5
Balter, R.E., Miller, L.L., Schmidt, K.T., and Dykstra, L.A. (2009). Effects of the competitive NMDA receptor antagonist LY235959 on the antinociceptive response to acute and chronic morphine in WT and NR1 KD mice. Poster presented at the College on Problems of Drug Dependence: Reno, Nevada, 2009. Howlett, A, Franklin, S.O., Horton, K.K., Miller, L.L., and Dykstra, L.A. CB1 receptor knockout affects brain adaptations to stress and aging. 18 th Annual Symposium of the International Cannabinoid Research Society. Aviemore, Scotland, 2008. Miller, L.L., Henry, F.E., Fischer, B.D., Ward, S.J., and Dykstra, L.A. Chronic unpredictable stress alters cocaine conditioned place preference in CB1 knockout mice but not their wildtype littermates. Poster presented at the College on Problems of Drug Dependence: San Juan, Puerto Rico, 2008. Fischer, B.D., Miller, L.L., Henry, F.E., Picker, M.J. and Dykstra, L.A. Metabotropic glutamate receptor antagonists increase the antinociceptive efficacy of m-opioid agonists. Poster presented at the College on Problems of Drug Dependence: San Juan, Puerto Rico, 2008. Miller, L.L., Franklin, S.O., Howlett, A.C., Ward, S.J., Henry, F., Fischer, B.D., and Dykstra, L.A. Chronic unpredictable stress alters cocaine conditioned place preference in CB1 cannabinoid receptor knockout mice. Poster presented at the College on Problems of Drug Dependence: Quebec, Canada, 2007. Fischer, B.D., Zimmerman, E.I., Miller, L.L., Picker, M.J. and Dykstra, L.A. (2007). The metabotropic glutamate 2/3 receptor antagonist LY341495 potentiates the antinociceptive effects of morphine in C57BL/6 mice. Presented at the College on Problems of Drug Dependence: Quebec City, Canada. Fischer, B.D., Henry, F., Miller, L.L., Ward, S.J., and Dykstra, L.A. Attenuation of morphine antinociceptive tolerance by an NMDA receptor antagonist and a cannabinoid receptor agonist: interactive effects. 2007 Experimental Biology Meeting Abstract. FASEB J. 2007 21:563.9 Dykstra, L.A. and Miller, L.L. Deletion of the NR1 subunit of the N-methyl-D-aspartate (NMDA) glutamate receptor alters morphine conditioned place preference. Poster presented at the College on Problems of Drug Dependence: Scottsdale AZ, 2006. Miller, L.L., McKinney, A.P., Wagner, J.P. and Galizio, M. Potentiation of learning disruption by combinations of morphine and NMDA antagonist LY235959. Oral communication presented at the College on Problems of Drug Dependence: Orlando, FL, 2005. Miller, L.L., Wagner, J. P., Ferguson, A. T., Pitts, R. C. & Galizio, M. Repeated acquisition in rats: Effects of morphine on spatial and non-spatial learning. Poster presented at the Annual Meeting of the Society for Neuroscience, Orlando, FL November, 2002. 6
Miller, L.L., Buda, D., McKinney, P., McGann, A., Keith, J., Pitts, R. & Galizio, M. The effects of morphine and pentobarbital on repeated acquisition and performance in the Morris Swim Task. Poster presented at the Annual Meeting of the Southeastern Association for Behavior Analysis, Wilmington, NC, October, 2001. Pena, T., Curl, B., Miller, L.L., Nelson, D., Wagner, J., Keith, J., Pitts, R. C. and Galizio, M. Repeated reversals of olfactory discriminations in rats. Poster presented at the Annual Meeting of the Association for Behavior Analysis, New Orleans, May, 2001 7