Table of contents 1 About... 3 1.1 ABOUT THE COMPANY...3 1.2 ViroGen News...3 1.3 Contact ViroGen...3 2 Services...4 2.1 Services...4 3 Products... 4 3.1 Categories... 4 3.2 Blood Group Antibodies... 5 3.3 CMV... 5 3.4 Epstein-Barr Virus...6 3.5 HAV...6 3.6 HBV...6 3.7 HCV...6 3.8 HDV...7 3.9 HEV... 7 3.10 HIV-1 (2)... 7 3.11 HSV... 8 3.12 HTLV-1 (2)...8 3.13 Rubella virus...8 3.14 SARS... 9 3.15 Signal Transduction Antibodies...9 3.16 Syphilis... 11
3.17 Tick-born Encephalitis Virus...11 3.18 Toxoplasma gondii... 11 3.19 Varicella Zoster Virus... 11 3.20 Viral antibodies...12 3.21 West Nile Virus... 13 4 Disclaimer...13 4.1 Disclaimer...13 Page 2
1 About 1.1 ABOUT THE COMPANY VIROGEN Corporation is a leading provider of antigens and antibodies to the research and diagnostics markets. We are located in Greater Boston, a world center of science and technology. Reagents include viral antigens and monoclonal antibodies, in addition to FAS antigens and the signal transduction monoclonal anti-gsk3 beta. Product offerings are expanded regularly, and our multilingual staff is prepared to meet worldwide needs for biological reagents, as well as providing contract research services. Founded in 1995 by scientists from Harvard and M.I.T., the Corporation offers products for manufacturing and research in the fields of: Apoptosis HIV Hepatitis Rotavirus Signal transduction At VIROGEN, we make biotechnology work. Let us work for you! 1.2 ViroGen News Virogen is proud to announce a new Rabbit polyclonal antibody designed specifically to react with HCV NS5a genotype 2A, catalog number 276-A. It is offered at a special price of $195.00 per 100 ug vial until September 30th (regular price is $225/100 ug). The anti-hcv NS3 monoclonal antibody, catalog number 217-A, has been shown to react with genotype 2A as well. Please visit www.virogen.com for a complete HCV reagent listing. As always we hope to serve you research and diagnostic needs. Sincerely, Team ViroGen 1.3 Contact ViroGen Telephone Voice (617) 926-9167 Fax Mailing Address 200 Dexter Avenue Watertown, MA 02472 USA E-Mail Page 3
(617) 926-9157 Bulk Orders (800) 847-6436 info@virogen.com WWW http://www.virogen.com 2 Services 2.1 Services ViroGen provides the following services: Custom Monoclonal Antibody Production Custom antibody and antigen modifications with biotin, Rhodamine and FITC Custom Cloning and Recombinant Protein Purification Services 3 Products 3.1 Categories Blood Group Antibodies CMV Epstein-Barr Virus HAV HBV HCV HDV HEV HIV-1 (2) HSV HTLV-1 (2) Rubella virus SARS Signal Transduction Antibodies Syphilis Page 4
Tick-born Encephalitis Virus Toxoplasma gondii Varicella Zoster Virus Viral antibodies West Nile Virus 3.2 Blood Group Antibodies 131-A, anti-rhod human antigen IgG1 132-A, anti-a1, A2 human blood antigen IgM 133-A, anti-a1, A2, A3 human blood antigen IgM 134-A, anti-b human blood antigen IgM 135-A, anti-ab human blood antigen IgM 136-A, anti-rh(o)d human antigen IgM 137-A, anti-rh(o)d and Rh(o)Dii human Rhesus system antigen IgG1 138-A, anti-rhoc human Rhesus system antigen IgM 139-A, anti-a1, A2 human blood antigen IgM 140-A, anti-b human blood group antigen IgM 141-A, anti-h n/ab human blood antigen IgM 142-A, anti-h ab human blood antigen IgM 144-A, anti-m human blood antigen IgM 145-A, anti-n human blood antigen Ig2b 146-A, Antiglobulin (COOMBS) Rabbit polyclonal 3.3 CMV 00188-V, CMV Pp65 (UL83) recombinant antigen Page 5
3.4 Epstein-Barr Virus 00211-V, HHV-4 recombinant p18 antigen 3.5 HAV 00159-V, HAV VP1-P2A recombinant antigen 00160-V, HAV VP4-VP2 recombinant antigen 00161-V, HAV P2C-P3A recombinant antigen 00162-V, HAV P3C recombinant antigen 00163-V, HAV VP3 recombinant antigen 00164-V, HAV VP1-P2A recombinant antigen 00165-V, HAV HAV P2C recombinant antigen 00166-V, HAV P2C-P3A recombinant antigen 3.6 HBV 00120-V, HBV core recombinant antigen HBcAg 00121-V, HBV core recombinant antigen HBcAg 3.7 HCV 00115-V, HCV core recombinant antigen 00115-V-B, HCV core recombinant antigen 00115-V-F, HCV core recombinant antigen 00115-V-R, HCV core recombinant antigen 00116-V, HCV NS4 recombinant antigen Available Genotypes: 1A; 1B; 2A; 3A 00116-V-B, HCV NS4 recombinant antigen Page 6
00116-V-F, HCV NS4 recombinant antigen 00116-V-R, HCV NS4 recombinant antigen 00117-V, HCV NS3 recombinant antigen 00150-V, HCV core 2-119aa recombinant antigen. 00151-V, HCV core 24 antigen. 00153-V, HCV NS3 1192-1456aa recombinant antigen 00154-V, HCV NS3 1359-1456aa antigen. 00155-V, HCV NS4 mosaic recombinant antigen 00156-V, HCV NS4 1916-1947aa recombinant antigen. 00157-V, HCV NS5 2061-2302aa recombinant antigen. 00158-V, HCV NS5 2212-2313aa recombinant antigen. 00119-V, HCV NS3-NS4A fusion recombinant antigen-immunodominant Regions Genotype 1A 3.8 HDV 00167-V, HDV Ag recombinant antigen 3.9 HEV 00131-V, HEV (Birma) ORF2 recombinant antigen 00132-V, HEV (Birma) ORF2 recombinant antigen 00133-V, HEV (Birma) ORF2 recombinant antigen 3.10 HIV-1 (2) 00089-V, HIV I VIF recombinant antigen Full Length 00088-V, HIV II gp160 recombinant antigen-immunodominant Regions 00111-V, HIV-1 gag p24 recombinant antigen Page 7
00112-V, HIV-1 nef recombinant antigen 00113-V, HIV-1 env gp41 recombinant antigen 00114-V, HIV -2 env gp36 recombinant antigen 00173-V, HIV-2 gp32 recombinant antigen.. 00175-V, HIV 1, 2 envelope recombinant antigen. 00178-V, HIV type O envelope antigen. 00179-V, HIV -2 env gp36 recombinant antigen. 00180-V, HIV 2 gp36 envelope antigen. 00198-V, HIV-1 reverse transcriptase recombinant antigen. 00199-V, HIV-1 intergase antigen. 3.11 HSV 00181-V, HSV-1 gd recombinant antigen a 00182-V, HSV-2 gd recombinant antigen 00183-V, HSV-2 gd recombinant antigen 00184-V, HSV-1 gd recombinant antigen 3.12 HTLV-1 (2) 00203-V, HLTV-I envelope recombinant antigen. 00204-V, HLTV-I p24 core recombinant antigen. 00205-V, HTLV-1 virus mosaic recombinant antigen 00702-V, HTLV II ENV recombinant antigen-immunodominant Regions 3.13 Rubella virus 00215-V, Rubella virus E1 mosaic recombinant antigen Page 8
00216-V, Rubella virus E2 recombinant antigen 00217-V, Rubella virus capsid (C) recombinant antigen 3.14 SARS 00191-V, SARS-Associated Coronavirus E recombinant antigen 00192-V, SARS-Associated Coronavirus Nucleocapsid recombinant antigen 00193-V, SARS-Associated Coronavirus Nucleocapsid recombinant antigen C 00194-V, SARS-Associated Coronavirus M recombinant antigen a.a. 182-216. 00195-V, SARS-Associated Coronavirus Spike mosaic recombinant antigen 00196-V, SARS-Associated Coronavirus Spike mosaic recombinant antigen 00197-V, SARS-Associated Coronavirus Spike mosaic recombinant antigen 3.15 Signal Transduction Antibodies 101-A, anti-glutathione monoclonal antibody IgG1 011-A, anti-gsk3 Beta IgG2a (monoclonal). 019-A, anti-fas IgG1 (monoclonal) 029-A, anti-fas IgG1 (monoclonal) 039-A, anti-fas IgG1 (monoclonal) 049-A, anti-fas IgM (monoclonal) 059-A, anti-slam anti-cdw150 IgG2a (monoclonal) 069-A, anti-cd37 IgG2b (monoclonal) 079-A, anti-nuclear Antigen (Proliferating Cells) IgM (monoclonal) 066-A, anti-p53, clone BP53-12 060-A, anti-cd3 monoclonal antibody 061-A, anti-cd4 monoclonal antibody Page 9
062-A, anti-cd8 monoclonal antibody 063-A, anti-cd16 monoclonal antibody 064-A, anti-cd20 monoclonal antibody 065-A, anti-cd22 monoclonal antibody 067-A, anti-cd45 RA IgG2 monoclonal antibody 068-A, anti-cd54 IgG2b-k monoclonal antibody 071-A, anti-cd19 IgG1 monoclonal antibody 089-A, anti-cd66e IgG1 monoclonal antibody 501-A, anti-cd3 T-cell 502-A, anti-cd4 T helper cells 503-A, anti-cd5 All T-cells 504-A, anti-cd7 All T-cells 505-A, anti-cd8 T cytotoxic/supressor cells 506-A, anti-cd10 Lymphoblasts 507-A, anti-cd16 NK-cells, monocytes, granulocytes 508-A, anti-cd18 Leucocytes 509-A, anti-cd20 B-lymphocytes 510-A, anti-cd22 B-lymphocytes 511-A, anti-cd25 IL-2 receptor expressed on activated T and B cells 512-A, anti-cd26 Activated T, B lymphocytes and macrophages 513-A, anti-cd34 Hematopoietic precursor cells 514-A, anti-cd38 Hematopoietic precursors, thymocytes, activated T-cells, plasma cells 515-A, anti-cd45 Leukocytes 516-A, anti-cd45 RA B-cells, T-cells, NK-cells 517-A, anti-icam-3, Leukocytes 518-A, anti-transferrin receptor on activated T-B-, cells 519-A, anti-fas antigen Page 10
520-A, anti-hla-dr 521-A, anti-hla-abc on all Leukocytes 522-A, anti-igm Heavy chain expressed on B cells 523-A, anti-cortical thymocytes 2001-V, GRX1 2002-V, GRX2 3.16 Syphilis 00141-V, T. Pallidum recombinant antigen p15 (full length) 00142-V, T. Pallidum recombinant antigen p17 (full length) 00143-V, T. Pallidum recombinant antigen p45 (full length) 00144-V, T. Pallidum recombinant antigen TmpA (full length) 3.17 Tick-born Encephalitis Virus 00214-V, Tick-born encephalitis virus ge recombinant antigen 3.18 Toxoplasma gondii 00206-V, Toxoplasma gondii MIC 3 recombinant antigen 00207-V, Toxoplasma gondii P24 (GRA1) recombinant antigen 00208-V, Toxoplasma gondii P29 (GRA7) recombinant antigen 00209-V, Toxoplasma gondii P30 (SAG1) recombinant antigen 3.19 Varicella Zoster Virus 00200-V, VZV ge recombinant antigen a.a. 48-135. Page 11
00201-V, VZV ORF9 recombinant antigen a.a. 6-28/76-100. 00202-V, VZV ORF26 recombinant antigen a.a. 9-33/184-208. 3.20 Viral antibodies 012-A, anti-hiv-1 p24 IgG1 (monoclonal) 013-A, anti-hiv-1 p55/17 IgG1 (monoclonal) 014-A, anti-hiv-1 p17 IgG1 (monoclonal) 0114-A, anti-hiv-2 gp36 IgG1 (monoclonal) 015-A, anti-hiv-1 gp41 IgG1 (monoclonal) 016-A, anti-hcv core IgG2a (monoclonal) 017-A, anti-hcv core IgG2a (monoclonal) 018-A, anti-hcv NS4 IgG2a (monoclonal) 020-A, anti-hsv (I) gd IgG1 (monoclonal) 021-A, anti-hsv (II) gb IgG1 (monoclonal) 022-A, anti-hcmv IE pp72 IgG2a (monoclonal) 023-A, anti-hcmv IE pp65 IgG1 (monoclonal) 024-A, anti-hcmv gb IgG1 (monoclonal) 025-A, anti-adenovirus E11 IgG2a (monoclonal) 026-A, anti-adenovirus C11 IgG2a (monoclonal) 027-A, anti-rotavirus p42 IgG2a (monoclonal) 028-A, anti-tge IgG1 (monoclonal) 276-A, anti-hcv NS5b rabbit (polycnonal) Reactive with genotype 2A JFH-1 266-A, anti-hcv NS5b rabbit (polycnonal) Page 12
3.21 West Nile Virus 00401-V, West Nile Virus Envelope recombinant antigen-immunodominant region 00402-V, West Nile Virus Pre-M recombinant antigen-immunodominant region 4 Disclaimer 4.1 Disclaimer Due to the nature of our business, prices, specifications, warranties and availability's are subject to change without notice. Terms of Sale Orders Orders will be accepted by fax, phone, or mail. Orders may be confirmed but should be marked " Confirming Only. " All orders must contain a purchase order number and the name of the person who is placing the order. Address orders to: ViroGen Corp. 200 Dexter Avenue Watertown, MA 02472 T: (617) 926-9167 F: (617) 926-9157 info@virogen.com Special Orders All shipments with dry ice are subject to a $25.00 handling charge. Condition of Sales Under the U.S. Food and Drug Administration (FDA), several of the products listed are available only for research uses. The Code of Federal Regulations, Title 21, Sections 312.9 and 809.10 explicitly state that such research products are for investigational use in laboratory research animals or in vitro research. Products are for research or manufacturing use only unless they are labeled for in vitro diagnostic use. Products should not be used for human therapeutics. Price All prices are specific to a location. Prices reflect list price and are subject to change without notice. Australian prices do not include Goods and Service Tax (GST). Documents It is the customer's responsibility to notify VIROGEN of all necessary documents or permits needed for customs clearance or other purposes. Payment Payment is due upon receipt of goods unless prior arrangements have been made. A 1.5% monthly late charge on account balances over 30 days past due will be added to invoices from date of shipment. MasterCard, VISA and American Express are accepted at time of purchase. Page 13
Freight Because of the nature of VIROGEN's products we regret that we are unable to ship to a home address or a P.O. Box. FOB VIROGEN facility. Freight charges are to be prepaid or orders will be shipped freight collect unless prior arrangements have been made for charges to be added to invoice. VIROGEN reserves the right to ship orders via the best method which will insure the stability of the product, minimize freight costs and allow efficient order tracking. Shipments are sent overnight Monday-Thursday. Shipments to Canada are sent overnight Monday-Wednesday. Returns No returns can be accepted without prior approval by VIROGEN. Only unopened merchandise may be returned. VIROGEN must be notified within 10 days of receipt. All shipping costs and a 25% handling fee will be paid by the customer. Product must be received by VIROGEN within 10 days after return has been authorized. In certain cases such as a return of dated material or shipments involving special handling, an additional fee may be required. No return of custom products will be authorized if product meets specifications agreed upon prior to shipment. Limited Warranty VIROGEN warrants, to the original purchaser only, that the products listed in the catalog are of the composition and purity described therein. Buyer's exclusive remedy under this warranty is expressly limited to replacement of unused product with product meeting the catalog description. Statements made about these products by VIROGEN's sales persons or VIROGEN's distributors do not constitute warranties and should not be relied upon by buyer. The entire risk as to the performance of this product is assumed by buyer. VIROGEN shall not be liable for indirect, special or consequential damages resulting from use of the product. There are no implied warranties relating to the product, including any implied warranties or merchantability or of fitness for a particular research use or other purposes, are disclaimed. Product Specifications Data sheets and other product information for most VIROGEN products can be found on this Web site. For additional product information please contact Technical Support. Page 14