We look forward to both your participation and contribution to this meeting.

Dear Colleagues, It is a great pleasure to invite you to participate in the joint symposium MALIGNANT PLEURAL MESOTHELIOMA: A CHANGING PARADIGM OF CARE organized by Division of Thoracic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, USA, Department of Thoracic Surgery, Marmara University Hospital, Istanbul, TURKEY and Department of Pulmonary Medicine, Osmangazi University Hospital, Eskisehir, TURKEY. The event will take place in Istanbul on 27-28 May 2011. Istanbul is one of the truly romantic cities of the world, with its land spanning both Asia and Europe and divided by the scenic waters of the Bosphorus. Let s meet where the continents meet. We look forward to both your participation and contribution to this meeting. Organising Committee

&COMMITTEES& SYMPOSIUM DIRECTORS: David J. Sugarbaker Hasan F. Batırel CO- DIRECTORS: Mustafa Yüksel Muzaffer Metintaş FACULTY (alphabetic order): Rengin Ahiskali, MD, Department of Pathology, Marmara University Hospital, Istanbul, Turkey Hasan F.Batirel, MD, PhD, Department of Thoracic Surgery, Marmara University Hospital, Istanbul Turkey Raphael Bueno, MD, Division of Thoracic Surgery, Department of Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, USA Hale Basak Caglar, MD, Department of Radiation Oncology, Marmara University Hospital, Istanbul Turkey Ayten Kayi Cangir, MD, Department of Thoracic Surgery, Ankara University Hospital, Ankara, Turkey Lucian R. Chirieac, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, USA Muzaffer Metintas, MD, Department of Pulmonary Medicine, Osmangazi University Hospital, Eskisehir, Turkey Selma Metintas, MD, Department of Public Health, Osmangazi University Hospital, Eskisehir, Turkey Tomasso Mineo, MD, Department of Surgery, Tor Vergata University, Rome, Italy Philip Nafteux, MD, Department of Thoracic Surgery, Catholic University of Leuven, Leuven, Belgium Kazunori Okabe, MD, Division of Thoracic Sugery, Yamaguchi Ube Medical Center, Yamaguchi, Japan Isabelle Opitz, MD, Department of Thoracic Surgery, Zurich University Hospital, Zurich, Switzerland William G. Richards, PhD, Division of Thoracic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, USA Abdurrahman Senyigit, MD, Department of Pulmonary Medicine, Dicle University Hospital, Diyarbakir, Turkey David J.Sugarbaker, MD, Division of Thoracic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, USA Serdar Turhal, MD, Division of Medical Oncology, Department of Internal Medicine, Marmara University Hospital, Istanbul, Turkey Walter Weder, MD, Department of Thoracic Surgery, Zurich University Hospital, Zurich, Switzerland Bedrettin Yildizeli, MD, Department of Thoracic Surgery, Marmara University Hospital, Istanbul, Turkey Mustafa Yuksel, MD, Department of Thoracic Surgery, Marmara University Hospital, Istanbul, Turkey Fulden Yumuk, MD, Division of Medical Oncology, Department of Internal Medicine, Marmara University Hospital, Istanbul Turkey

&CONTACT DETAILS& Prof. Dr. Hasan Fevzi Batırel Address: Marmara Universty Faculty of Medicine 34662 Haydarpaşa İstanbul Turkey Tel :+90 216 414 47 34 Fax :+90 216 449 18 28 Mobile :+90-533-6467877 E-mail :hbatirel@marmara.edu.tr GENERAL INFORMATION, REGISTRATION, HOTEL RESERVATION, EXCURSIONS, EXHIBITION 441. Cadde (Eski 8.Cadde) No:1 06610 Birlik Çankaya/Ankara/TÜRKİYE Tel : +90 312 454 00 00 Fax : +90 312 454 00 01 E-mail : mpm2011@flaptour.com.tr

&SCIENTIFIC PROgRAM& 27 MAY 2011, FRIDAY Registration, Opening Concert, Faculty Dinner 28 MAY 2011, SATURDAY 08:00-08:30 Registration and Continental Breakfast 08:30-08:40 Introduction to the symposium David J. Sugarbaker, Hasan F. Batirel SESSION 1: EPIDEMIOLOGY TO CLINIC 08:40-09:00 Mesothelioma Epidemiology: Features of Environmental and Occupational Exposure Muzaffer Metintas 09:00-09:20 Clinical assessment and variations in clinical presentation Abdurrahman Senyigit 09:20-09:40 Asbestos minerals and molecular mechanisms of malignant transformation Kazunori Okabe 09:40-10:00 Diagnostic challenges in mesothelioma pathology Lucian R. Chirieac 10:00-10:30 COFFEE BREAK SESSION 2: UNDERSTANDING THE DISEASE Chairs: Isabelle Opitz, Mustafa Yüksel 10:30-11:00 The need for a new staging system: Diverging from TNM William G. Richards 11:00-11.30 Genomics: Role in diagnosis, treatment planning and prognosis Raphael Bueno 11:30-12:00 Testing for chemosensitivity: Towards a better combination David J. Sugarbaker 12:00-13:00 LUNCH SESSION 3: TREATMENT OPTIONS: A HOPE FOR LONG TERM SURVIVAL Chairs: Philip Nafteux, Ayten Kayi Cangir 13:00-13:30 Heated intraoperative chemotherapy: Technique and patient selection David J. Sugarbaker 13:30-14:00 Neoadjuvant treatment and EPP: Difficult treatment to favorable outcome Walter Weder 14:00-14:30 Long-term Survival and Cure: A dream come true David J. Sugarbaker 14:30-15:00 COFFEE BREAK

SESSION 4: PERFECTING THE MULTIMODALITY TREATMENT AND OUTCOME Chairs: Serdar Turhal, Bedrettin Yıldızeli 15:00-15.20 Sparing the healthy with better local control: New techniques in radiation treatment Hale Basak Caglar 15:20-15:40 Chemotherapy: Which agents and when? Fulden Yumuk 15:40-16:00 Trimodality treatment Hasan F. Batirel 16:00-16:20 Quality of life in surgically treated patients with malignant pleural mesothelioma Tomasso Mineo 16:20-16:40 Summing Up and Closure Hasan F.Batirel, David J Sugarbaker

&GENERAL INFORMATION& SYMPOSIUM VENUE Resat Kaynar Auditorium Marmara University Faculty of Medicine, Haydarpasa, Istanbul ACCOMODATION Marriot Asia, Kozyatagi, Istanbul SYMPOSIUM LANGUAGE English and Turkish (Simultaneous translation will be available) SYMPOSIUM WEB www.mpm2011.org NAME BADGES Only officially registered participants wearing their official Malignant 2011 name badges will be allowed to the symposium venue. Please wear your badge visibly all the time. CERTIFICATES All certificates for all participants will be hand out on 28 May 2011. INSURANCE The Organizing Committee can accept no responsibility for accidents or damage to the private property of participants. Please make your own arrangements for health insureance and any other insurance desired DRIVING LICENCE International driving licences are recognised throughout Turkey. Car rental firms ask for a valid national licence or an international licence. RESTAURANT It is possible to find variour kinds of Turkish, Western, Asian, other cuisine in Istanbul.

&ABOUT ISTANBUL& The former capital of three successive empires Roman, Byzantine and Ottoman - the city is a fascinating mixture of the past and present, old and new, modern and traditional. The museums, churches, palaces, mosques and bazaars, and the sights of natural beauty seem inexhaustible. As you recline on the shores of the Bosphorus at the sunset contemplating the red evening light reflected in the windows and slender minarets on the opposite shore you understand, suddenly and profoundly, why so many centuries ago settlers chose to build on this remarkable site.

&REGISTratıon & ACCOMmODATION& SYMPOSIUM REGISTRATION FEES Specialist 75 Trainee 50 Registration fee includes; Admission to all sessions and exhibition areas Abstract Book Coffee Breaks and Lunck Box Welcome Reception SYMPOSIUM ACCOMMODATION FEES Marriott Asia Hotel Single Room Double Room 200 250 The rates mentioned above include bed and breakfast service. Please note that rates rates are quoted per person, per night. VAT (%8) is not included.

&REGISTratıon AND ACCOMMoDATION FORM& PARTICIPANT Name, Surname :... Registration Type : Specialist Trainee Accompanying Person Telephone :... Fax:... E-mail :... Address :... Accommadation Check in Date :.... Check out Date :... Room Type : Single Room Double Room Accompanying Person : 441. Cadde (Eski 8.Cadde) No:1 06610 Birlik Çankaya/Ankara/TÜRKİYE Tel : 0 312 454 00 00 Fax : 0 312 454 00 24 E- mail : mpm2011@flaptour.com.tr PAYMENT Bank Details Account Name : Bank Name : TL : EURO : Credit Card Type Visa Master Card Card Number: Expire Day : / Signatures

441. Cadde (Eski 8.Cadde) No:1 06610 Birlik Çankaya/Ankara/TÜRKİYE Tel : +90 312 454 00 00 Fax : +90 312 454 00 01 E-mail : mpm2011@flaptour.com.t