2012: How is most SEM/EDS Quantitative Analysis performed? By means of Standardless Analysis!

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2012: How is most SEM/EDS Quantitative Analysis performed? By means of Standardless Analysis! Al reflective coating, 20-50 nm YBa 2 Cu 3 O 7 E 0 = 20 kev X-rays Active silicon (intrinsic), 3 mm Au electrode, ~20 nm Si 'dead' layer (p-type), ~100 nm Electrons Holes Rear Au electrode, ~20 nm Inactive silicon (n-type), ~100nm Window: Be, BN, C (diamond), or polymer 0.1-7 µm - 1000 V CuKα EDS records the entire spectrum. It is very appealing to directly and quantitatively compare the x-ray intensities of different elements in a single EDS measurement.

What is Standardless Analysis? Standardless Analysis with EDS we measure the entire x-ray spectrum (~ 0.1 kev to E 0, E 0 up to 30 kev). Standardless Analysis attempts to quantitatively compares the suite of different elements within a single spectrum. 1. First principles standardless: uses only physical calculations of the x-ray generation, propagation, and detection for quantification. (RARE; e.g., NIST-NIH DTSA Classic) Measure this Calculate this I ch = ε (ω N A ρ C i /A) R (Q / (de/ds) de E 0 ω = fluorescence yield N A = Avogadro s number ρ = density C i = mass concentration of i A = atomic weight R = backscatter loss Q = ionization cross section de/ds = rate of energy loss E 0 = incident beam energy E c = excitation energy ε = EDS efficiency E c

Stainless Steel Analysis: Standardless Analysis Spectrum Label: Substrate steel 1 20 kev/0.5 na/300kx 6-29-94 offset=-30 Standardless Analysis Take-Off Angle: 40.00 Beam Entry Angle: 90.00 Beam kev: 20.00 Number of elements: 4 Elem & Line k-value Conc. Z A F SiKA1 0.0040 0.0084 0.8900 0.4579 1.0013 CrKA1 0.2001 0.1880 1.0035 0.9890 1.1758 FeKA1 0.6396 0.7180 1.0028 0.9693 1.0111 NiKA1 0.0716 0.0856 0.9870 0.9017 1.0000 Σ = 1.0000 The Analysis Total (sum of all constituents) is exactly 1.0000 Is this result comforting?

Stainless Steel Analysis: Standardless Analysis Spectrum Label: Substrate steel 1 20 kev/0.5 na/300kx 6-29-94 offset=-30 Standardless Analysis Take-Off Angle: 40.00 Beam Entry Angle: 90.00 Beam kev: 20.00 Number of elements: 4 Elem & Line k-value Conc. Z A F SiKA1 0.0040 0.0084 0.8900 0.4579 1.0013 CrKA1 0.2001 0.1880 1.0035 0.9890 1.1758 FeKA1 0.6396 0.7180 1.0028 0.9693 1.0111 NiKA1 0.0716 0.0856 0.9870 0.9017 1.0000 Σ = 1.0000 The Analysis Total (sum of all constituents) is exactly 1.0000 Is this result comforting? NO! The loss of any connection to the electron dose means the calculated Concentrations must be normalized to unity to have any meaning.

True First Principles Standardless Analysis DTSA Classic Standardless Miracle (Fiori, Swyt and Myklebust) Newbury, D. E., Swyt, C. R., and Myklebust, R. L., "'Standardless' Quantitative Electron Probe Microanalysis with Energy-Dispersive X-ray Spectrometry: Is It Worth the Risk?", Analytical Chemistry, 67 (1995) 1866-1871. Frequency 35 30 25 20 15 10 5 DTS A S tandardless, 20 kev Error bins are 10% relative wide 0-150 -100-50 0 50 100 150 Relative Error, % The errors here are 10 times worse than analysis with standards. The 95% range is ±50% relative. Conditions: SRMs, RMs, and stoichiometric compounds; E 0 =20 kev; photon energies above 0.9 kev (CuL); oxygen by assumed stoichiometry but not included in distribution

What is Standardless Analysis? Standardless Analysis with EDS we measure the entire x-ray spectrum (~ 0.1 kev to E 0, E 0 up to 30 kev). Standardless Analysis attempts to quantitatively compares the suite of different elements within a single spectrum. 1. First principles standardless: uses only physical calculations of the x-ray generation, propagation, and detection for quantification. (RARE; e.g., NIST-NIH DTSA Classic) 2. Remote Standards standardless: A library of spectra is measured on a suite of known standards (elements, binary compounds) at several beam energies with a known EDS detector. This library is used to estimate standard intensities appropriate to the local measurement environment (E 0, takeoff angle, and local detector efficiency), followed by matrix corrections. Final results must be normalized because of the loss of dose information.

Error Distribution for a Commercial Standardless Analysis: 1995 "Standardless SemiQuant" Frequency 50 40 30 20 10 Error bins are 5% relative wide 95% range =+25% rel 0-100 -50 0 50 100 Relative Error (%) Newbury, D. E., Swyt, C. R., and Myklebust, R. L., "'Standardless' Quantitative Electron Probe Microanalysis with Energy-Dispersive X-ray Spectrometry: Is It Worth the Risk?", Analytical Chemistry, 67 (1995) 1866-1871.

Error Distribution for a Commercial Standardless Analysis: 1995 "Standardless SemiQuant" Frequency 50 40 30 20 10 With such a broad error distribution, can we get the formula correct? Error bins are 5% relative wide 95% range =+25% rel 0-100 -50 0 50 100 Relative Error (%) Newbury, D. E., Swyt, C. R., and Myklebust, R. L., "'Standardless' Quantitative Electron Probe Microanalysis with Energy-Dispersive X-ray Spectrometry: Is It Worth the Risk?", Analytical Chemistry, 67 (1995) 1866-1871.

Standards-based and Standardless Analyses of a YBa 2 Cu 3 O 7 Single Crystal Can the analyst get the correct formula? (Oxygen by assumed stoichiometry) Y (true) Ba (true) Cu (true) 13.3 w/o 41.2 w/o 28.6 w/o Standards 13.8 (+ 4%) 41.1 (-0.2%) 28.1 (-2%) Cu-K ZAF Y 1 Ba 2 Cu 3 O 6.4 M1 17.3 (+30%) 40.0 (-3%) 26.7 (-7%) Cu-K Y 2 Ba 3 Cu 4 O 10 M1 15.8 (+19%) 36.2 (-12%) 31.6 (+10%) Cu-L Y 2 Ba 3 Cu 6 O 12 M2 16.5 (+24%) 38.7 (-6%) 28.7 (+0.4%) Cu-K Y 2 Ba 3 Cu 5 O 11 M2 16.8 (+26%) 39.5 (-4%) 27.6 (-3.5%) Cu-L Y 4 Ba 6 Cu 9 O 21

Standardless Analysis: Is it any better in 2012? A few analyses from a current commercial standardless program Analysis of Binary Sulfides with a commercial standardless analysis protocol. FeS (Troilite): measured formula is FeS FeS (meteoritic troilite) Spectrum: Acquisition FeS troilite (STD MT C) El AN Series unn. C norm. C Atom. C Error Relative Error % [wt.%] [wt.%] [at.%] [ wt.%] (C norm) -------------------------------------------- Fe 26 K-ser 62.40 62.86 49.29 1.7-1.1% S 16 K-ser 36.86 37.14 50.71 1.3 +1.8% -------------------------------------------- Total: 99.26 100.00 100.00

Standardless Analysis: Is it any better in 2012? A few analyses from a current commercial standardless program Analysis of Binary Sulfides with a commercial standardless analysis protocol. FeS: measured formula is FeS FeS (meteoritic troilite) Spectrum: Acquisition FeS troilite (STD MT C) El AN Series unn. C norm. C Atom. C Error Relative Error % [wt.%] [wt.%] [at.%] [ wt.%] (C norm) -------------------------------------------- Fe 26 K-ser 62.40 62.86 49.29 1.7-1.1% S 16 K-ser 36.86 37.14 50.71 1.3 +1.8% -------------------------------------------- Total: 99.26 100.00 100.00 ZnS Spectrum: Acquisition (ZnS (STD MT C) ZnS: measured formula is Zn 3 S 2 CuS: measured formula is Cu 3 S 2 And this is analysis with energetic K-peaks! These results are only one snapshot of the 2012 performance of one system. A more complete study is underway. El AN Series unn. C norm. C Atom. C Error Relative Error % [wt.%] [wt.%] [at.%] [wt.%] (C norm wt%) --------------------------------------------- Zn 30 K-ser 67.94 76.15 61.02 1.9 +14% S 16 K-ser 21.28 23.85 38.98 0.8-28% --------------------------------------------- Total: 89.23 100.00 100.00 CuS Spectrum: Acquisition El AN Series unn. C norm. C Atom. C Error Relative Error % [wt.%] [wt.%] [at.%] [wt.%] (C norm wt%) --------------------------------------------- Cu 29 K-ser 69.02 76.43 62.07 1.9 +15% S 16 K-ser 21.29 23.57 37.93 0.8-30% --------------------------------------------- Total: 90.31 100.00 100.00