Strategy and Architecture to Establish 'Smart Plants'

Strategy and Architecture to Establish 'Smart Plants'

About Intrigo We are a solu*on provider of Business Applica:ons focused on orchestra*ng Customer Value Networks in the changing SAP Enterprise technology landscape. S&OP Sen2ent DSIM Enterprise on HANA Track & Trace Innova2on BI Sequencing

About Intrigo BUILT ON HANA In- memory compu2ng Services Orchestra:ng Customer Value Networks SOP on HANA / DSIM / APO on HANA Biz Suite / Optessa BW on HANA Solu2ons Predic:ve modeling; Sen:ent; e- Serve Products HANA/ Syclo /Integra:on

Mylan Company Overview One of the world s leading pharmaceu*cal companies Sells products in approximately 140 countries and territories Global manufacturing capacity of approximately 54 billion doses Horizontally and ver*cally integrated plaeorm with global scale One out of every 12 prescrip*ons dispensed in the U.S. brand name or generic is a Mylan product A Fortune 500 company, with $6.9B in revenue Global workforce of more than 20,000

External World Trends Health care is becoming a precision- based industry Public- and private- sector integra:on in financing and delivery of care Health care sector is industrializing Process- driven valida:on Generics growth Campaign- driven manufacturing Mix: volume balancing Implica2ons Systems customiza:on leads to ever- smaller groups requiring tailored treatment regimes Expanding public- and private- sector rela:onships will create a mul:- trillion dollar global market Higher efficiency will enable mee:ng higher demands of more- informed customers Increased number of expiring patents and generics growth requiring beuer planning and refined manufacturing and business strategies

Smart Plants Loosely- Coupled Architecture GSCM Layer Global Supply Chain Processes Demand Planning Supply Planning Sourcing Logis:cs Execu:on SAP ERP Layer Global Transac:onal Processes Commercial/Order- to- Cash process Finance Transforma:on Local Addi:ons Integra2on Framework Shop Floor Opera:ons Expanded suite Func:onality flexed by plant Review by excep:on Frequent batch updates to SAP layer Flexibility, Agility and Time to Value The new architecture loosely couples the plant opera:ons from the SAP system Reduces risk of single point of failure Provides the plants with a flexible execu:on layer Ability to integrate with Supply Chain and SAP on an on- demand basis Manufacturing Layer Integra2on Framework Plant Automa:on Layer Localized Processes SCADA/PLC/DCS Barcode Weight

Smart Plants Ideal State Process View Plan and Source Produce Test Demand and Supply Planning Supplier Global MRP & Production Planning ERP Plant Maintenance Plant Process Control Manufacturing Execution System Calibration Serialization Lab Information System Equipment Equipment Automation and Data Historian Building System Data Acquisition Quality, Reg, EHS Training Document CAPAs / Cust Complaints / Change Control Incident Label Artwork EHS

Smart Plants Future State Business architecture Capabili:es and informa:on Applica:ons & technology Plants, with processes and systems that are standard and consistent by plant type, supported by global governance Global and coordinated approach to deploying capabili:es Access to informa:on throughout the plant Seamless informa:on flows within and across plants, supported by automated equipment Data visibility from shop floor Automated KPIs and analy:cs Increased quality/reduced risk through standardiza:on and automa:on across plants Presenta:on of workflows to operators and enforcement of tasks Automated data capture Poten:al to include equipment automa:on and Process Analy:cal Technologies (PAT) Faster ability to integrate M&A and stand up new plants, due to standard systems/processes Global SAP plaporm Manufacturing Execu:on System, including EBR, data historian and automa:on layer Integra:on of systems SAP, MES, TrackWise, LIMS and Empower

Pharma Manufacturing Best Prac2ces G x P compliance FDA 21 CFR Part 11 compliance Automated large- scale data collec*on using direct equipment interfaces Track and trace High up:me and asset u:liza:on Predictability of schedule/quality/yield Provide visibility to product cost drivers at a granular level Predic:ve maintenance to improve OEE management Master data granularity and accuracy Manage valida:on requirements Sample management

Impera2ves Leverage plant automa:on with considera*on to geography, plant configura*on, ROI and talent High availability 24x7 & reduced dependency on ERP up:me Self contained (Historian) Capacity and schedule visibility to maximize schedule adherence Core templates for family of products and leverage/enhance to meet localized plant needs Full compliance to serializa*on mandates and leverage the data across the extended supply chain Data capture focused towards process compliance Electronic Batch records Integrate and consolidate data collec:on and retrieval across systems (SAP- QM, LIMS, TrackWise, Minitab and Documentum)

Efficient Manufacturing Opera2ons Integrated Manufacturing Opera:ons enable Complete visibility and higher efficiency across the opera*onal con*nuum Reducing total and unit manufacturing costs consistently to meet customer requirements Ensure compliance with quality and safety standards Visibility to manufacturing opera2ons across the organiza2on to help adapt quickly to changes in customer orders and consistently deliver on commitments Integra2on and synch plant produc2on opera2ons with enterprise plan for higher efficiency while cuqng opera2on and inventory costs Integrated manufacturing controls with industry processes and standards to improve product quality, safety and compliance

Future State: Smart Plant Master Data Master Recipe Shop Floor Opera2ons Plant Control Des:na:on PP- PI SHEET CONFIRMATIONS EBR Scheduling & Sequencing MES SCADA SCALE LAB INFORMATICS OPERATOR HISTORIAN PLC Process sheets used to collect floor data directly to ERP Recipes are separated for each stage Weigh & Dispense Fluid Bed Dry Granulate Compress Package

Comprehensive Integra2on Business Strategy Integra:on Founda:on (IF) PlaPorm Scope Include: Applica:ons Integra:on (AI) and B2B Master Data (MDM) and Data Integra:on (DI) PlaPorm Strategic Themes: Unified Enterprise Plaaorms for AI/B2B and MDM/DI Plaaorms Enable interoperability and seamless, loosely coupled, agile, reusable, adaptable applica:on and data integra:on Enable service- oriented approach to integra:on Enable source- agnos:c, simplified integra:on workflows Common plaaorm that evolves with Mylan s unmet and unknown data needs Master data driving golden profiles that are consumed by front office and back office applica:ons and deployed to business processes Enable informa:on and data governance aids in effec:ve stewardship PlaPorm / Founda:on approach vs. Applica:on approach Implement the Technical Capabili:es to support future Business Capabili:es Services Integra:on Reac:ve Proac:ve

Coupled With a Robust KPI/Analy2cs Program Business Capabili:es Key Performance Indicators List List List Key Business Drivers List List List Reporting Key Metrics/Processes List List List Repor:ng Supply Chain Analytics HR Analytics Commercial Forecasting Commercial Analytics BI Capabili:es Customer Analytics Reporting Churn Analytics Quality Analytics Self Service Analytics Integrated Planning Single View of Customer Single View of Product BI Enablement Informa2on Supply Informa2on Landscape Informa2on Informa2on Delivery People Process Technology

Smart Plant - Solu2on Architecture SAP Business Suite Single source of truth for master data and transac2ons SAP SCM Suite SNOP, DP, SNP, GATP, PPDS, CAPA LIMS Laboratory Labeling System MES MBR Equipment management Weigh & Dispense Manufacturing & Packaging Execu2on and EBR Review by Excep2on Data Acquisi2on Systems/Historians Opera2onal Intelligence Document Managment system SOP Training Produc2on Data and Analy2cs SCADA/PLC /DCS Barcode System Weighing Scale

Summary: Business Benefits Ability to scale and respond nimbly to changes in demand, regulatory, produc*on requirements Reduce process cycle :me and increase inventory visibility Ability to understand plant efficiency and equipment effec:veness Increase right first :me batches Ability to onboard new sites / lines in an automated fashion Reduce risk of human error in data collec*on, compliance and process instruc*ons

Thank You! For addi*onal informa*on, please contact us at ndalmia@intrigosys.com or visit us at www.intrigosys.com. Follow us on Twiber: @IntrigoSys 2014 Intrigo Systems, Inc.