Brain Tumor Symposium Cortona (AR), Italy - July 2-4, 2010

Brain Tumor Symposium Cortona (AR), Italy - July 2-4, 2010 Honorary President John M. Tew Cincinnati, OH, USA Meeting President Sergio Maria Gaini Scientific Committee Eileen Bohan Giovanni Broggi Antonio E. Chiocca Francesco DiMeco Alessandro Olivi Zvi Ram Allen K. Sills Carlo L. Solero () () (Columbus, OH, USA) () () (Tel Aviv, Israel) (Nashville, TN, USA) () Organizing Committee Cecilia Casali Francesco DiMeco Federico Legnani Andrea Salmaggi Antonio Silvani Betty M. Tyler Department of Neurosurgery Fondazione IRCCS - Istituto Neurologico C. Besta - Via Celoria 11-20133 Milano (Italy) Ph. (+39) 02 70635027 Fax (+39) 02 70635017 - fdimeco@istituto-besta.it In collaboration with Associazione Italiana di Neuro-Oncologia Under the Auspicies

Program description This meeting will provide a unique opportunity to join a selected group of outstanding international experts from leading Institutions in the discussion of cutting-edge concepts and techniques in Neuro-Oncology. In addition, the format of the meeting, as well as its spectacular venue, will allow a friendly and productive interaction among participants and Faculty with ample opportunities to socialize. The program is aimed at advancing the knowledge of neurosurgeons, neurologists, medical oncologists, radiation oncologists, neuropathologists, neuroradiologists, internists, nurses, and researchers on the latest emerging neuro-oncology treatments. Educational Objectives Discuss integration of new laboratory findings into clinical practice Describe the latest advances in clinical CNS tumor care Present case studies and review with speaker panel Topics Pathology of CNS tumors GBM stem cells Management of brain metastases Advances in malignant gliomas Advances in neurosurgical oncology Surgery of eloquent areas Advances in skull base surgery Spine tumors

4 Mario Ammirati Michael L. J. Apuzzo Anthony L. Asher Tracy Batchelor Lorenzo Bello Lucia Benvenuti Mitchel S. Berger Alberto Bizzi Jaishri Blakeley Deborah Blumenthal Stefano Boriani Henry Brem Giovanni Broggi Jeffrey Bruce Peter C. Burger Fabio Calbucci Giampaolo Cantore Giulio Cantù Paolo Cappabianca Carmine M. Carapella Cecilia Casali Susan Chang Antonio E. Chiocca Pasquale Ciappetta Alfredo Cigliano Michael Cooper Domenico d Avella Roberto Delfini Alberto Delitala Franco DeMonte Francesco DiMeco Clemens Dirven Alessandro Ducati Hugues Duffau Charles G. Eberhart Vincenzo Esposito Matthew G. Ewend Andrea Falini Laura Fariselli Gaetano Finocchiaro Maurizio Fornari Sergio Maria Gaini MichelangeloGangemi Paola Gaviani Fred Gentili Isabelle Germano Peter C. Gerszten Felice Giangaspero Cesare Giorgi Roberta Glick Umberto Godano Columbus, OH, USA Los Angeles, CA, USA Charlotte, NC, USA Boston, MA, USA Livorno, Italy San Francisco, CA, USA Tel Aviv, Israel Bologna, Italy New York, NY, USA Bologna, Italy Pozzilli, Italy Naples, Italy Rome, Italy San Francisco, CA, USA Columbus, OH, USA Bari, Italy Naples, Italy Nashville, TN, USA Padua, Italy Rome, Italy Rome, Italy Houston, TX, USA Rotterdam, Holland Turin, Italy Montpellier, France Pozzilli, Italy Chapel Hill, NC, USA Naples, Italy Toronto, Canada New York, NY, USA Pittsburgh, PA, USA Rome, Italy Terni, Italy Chicago, IL, USA Cagliari, Italy Provisional Faculty

Ziya L. Gokaslan Stuart A. Grossman Giancarlo Guizzardi Florence, Italy Lawrence R. Kleinberg Chang-Hyuk Kwon Columbus, OH, USA Fred Lang Houston, TX, USA John J. Laterra Sean Lawler Columbus, OH, USA Federico Legnani Linda Liau Los Angeles, LA, USA Charles Liu Los Angeles, LA, USA Russell Lonser Rockville, MD, USA Francesco Maiuri Naples, Italy Yael Mardor Israel Carlo E. Marras Robert L. Martuza Boston, MA, USA Ehud Mendel Columbus, OH, USA Arya Nabavi Kiel, Germany Ichiro Nakano Columbus, OH, USA Massimiliano Neroni Rome, Italy Alessandro Olivi Bianca Pollo Alfredo Quinones-Hinojosa Zvi Ram Tel Aviv, Israel Brent Reynolds Gainesville, FL, USA Laurence D. Rhines Houston, TX, USA Gregory J. Riggins Roberta Rudà Turin, Italy Michael Sabel Düsseldorf, Germany Andrea Salmaggi Maurizio Salvati Rome, Italy Prakash Sampath Providence, RI, USA Antonio Santoro Rome, Italy Raymond Sawaya Houston, TX, USA Massimo Scerrati Ancona, Italy Allen K. Sills Nashville, TN, USA Antonio Silvani Riccardo Soffietti Turin, Italy Dennis A. Steindler Gainesville, FL, USA Rafael Tamargo John M. Tew Cincinnati, OH, USA Reid Thompson Nashville,TN, USA Tarik Tihan San Francisco, CA, USA Francesco Tomasello Messina, Italy Giuseppe Trincia Trieste, Italy Pietro P. Versari Alessandria, Italy Angelo Luigi Vescovi Kevin Walter Rochester, NY, USA Ronald E. Warnick Cincinnati, OH, USA Fumio Yamaguchi Tokio, Japan 5

Brain Tumor Symposium Cortona (AR), Italy - July 2-4, 2010 Friday, July 2 nd 08,00 Opening Remarks Sergio M. Gaini, John M. Tew, Antonio E. Chiocca, Francesco DiMeco, Alessandro Olivi, Allen K. Sills Pathology Discussant: Moderators: Tarik Tihan Yael Mardor, Bianca Pollo, Maurizio Salvati 08,05 Special Lecture: Peter C. Burger 08,25 Gregory J. Riggins 08,40 Felice Giangaspero 08,55 Charles G. Eberhart 09,10 Sean Lawler 09,25 Michael Cooper 09,40 Deborah Blumenthal 09,55 Russell Lonser 10,10 Discussion and Q&A Tarik Tihan 10,30 Coffee Break Stem cell symposium Discussant: Moderators: 10,45 Dennis A. Steindler 11,00 Brent Reynolds 11,15 Angelo Luigi Vescovi 11,30 Ichiro Nakano 11,45 Chang-Hyuk Kwon Alfredo Quinones-Hinojosa Carmine M. Carapella, Gaetano Finocchiaro, Antonio Silvani 6

Friday, July 2 nd 12,00 Isabelle Germano 12,15 Discussion and Q&A Alfredo Quinones-Hinojosa 12,35 Keynote: Michael L.J. Apuzzo 12,55 Lunch 13,50 Open abstract Session I 5 minutes for presentation 14,50 Moderators: Umberto Godano, Giuseppe Trincia 14,50 Open abstract Session II 5 minutes for presentation 15,50 Moderators: Lucia Benvenuti, Paola Gaviani 15,50 Coffee Break Brain tumor metastases Discussant / audience response: Prakash Sampath Moderators: Alberto Delitala, Laura Fariselli, Francesco Maiuri 16,00 Special lecture: Raymond Sawaya 16,20 Riccardo Soffietti 16,35 Matthew G. Ewend 16,50 Ronald E. Warnick 17,05 Lawrence R. Kleinberg 17,20 Charles Liu 17,35 Short communication: Andrea Salmaggi 17,45 IML CLINICAL CASES audience response Prakash Sampath 18,50 End of session 19,30 Opening Cocktail 7

Saturday, July 3 rd Advances in malignant gliomas Moderators: Domenico d Avella, Clemens Dirven, Roberta Glick 08,00 Special Lecture: Robert L. Martuza 08.20 John J. Laterra 08.35 Stuart A. Grossman 08.50 Reid Thompson 09,05 Susan Chang 09,20 Jaishri Blakeley 09,35 Michael Sabel 09,50 Tracy Batchelor 10,05 Special lecture: Henry Brem 10,25 Discussion and Q&A Antonio E. Chiocca 10,45 Coffee Break Advances in glioma and meningioma surgery Discussant: Moderators: Allen K. Sills Michelangelo Gangemi, Antonio Santoro, Massimo Scerrati 11,00 Special lecture: John M. Tew 11,20 Alessandro Olivi 11,35 Arya Nabavi 11,50 Giovanni Broggi 12,05 Fumio Yamaguchi 12,20 Kevin Walter 12,35 Special Lecture: Jeffrey Bruce 12,55 Discussion and Q&A Allen K. Sills 13,15 Lunch 8

Saturday, July 3 rd Surgery of eloquent areas Moderators: Alberto Bizzi, Alessandro Ducati, Vincenzo Esposito 14,15 Special Lecture: Mitchel S. Berger 14.35 Andrea Falini 14,50 Hugues Duffau 15,05 Lorenzo Bello 15,20 Zvi Ram 15,35 Fred Lang 15,50 Short communication: Roberta Rudà 16,00 IML CLINICAL CASES audience response Anthony L. Asher 17,00 Coffee break 17,15 Open abstract Session III 5 minutes for presentation 18,15 Moderators: Cecilia Casali, Pasquale Ciappetta 18,15 Open abstract Session IV 5 minutes for presentation 19,15 Moderators: Federico Legnani, Carlo E. Marras 9

Sunday, July 4 th Skull base Discussant: Moderators: 08,30 Paolo Cappabianca 08,45 Franco DeMonte 09,00 Giulio Cantù 09,15 Roberto Delfini 09,30 Fred Gentili 09,45 Mario Ammirati 10,00 Discussant and Q&A Rafael Tamargo 10,20 Coffee Break Rafael Tamargo Fabio Calbucci, Cesare Giorgi, Francesco Tomasello Spine symposium Discussant: Moderators: Giancarlo Guizzardi Alfredo Cigliano, Massimiliano Neroni, Pietro P. Versari 10,35 Special Lecture: Ziya L. Gokaslan 10,55 Peter Gerszten 11,10 Lawrence D. Rhines 11,25 Stefano Boriani 11,40 Ehud Mendel 11,55 Maurizio Fornari 12,10 Giampaolo Cantore 12,25 Discussant and Q&A Giancarlo Guizzardi 12.55 Closing remarks Antonio E. Chiocca, Francesco DiMeco, Alessandro Olivi, Allen K. Sills 10

Scientific Information Language The official language of the Meeting is English. Abstract submission You are invited to submit an abstract for presentation at the 9 th International Meeting UPDATES IN NEURO-ONCOLOGY. A panel of physicians will blindly review each submission. Abstracts of completed or on-going neuro-oncology research, clinical projects or novel programs will be accepted. The selected abstracts will be presented during the conference. Prize: A 500 euros first prize award will be given to the best abstract. Authors must submit abstracts online at: www.csrcongressi.com/2010x16/ Deadline: April 30 2010. Expenses Authors of accepted papers must be prepared to pay all personal expenses incurred including meeting registration, travel and accommodation during the Meeting. CME Accreditation CME Accreditation will be applied for Italian Participants only. Variations The Scientific and the Organizing Secretariats reserve the right to make whatever change to the program they deem necessary for scientific and/or technical reasons, in compliance with Ministry regulations on CME credits. Attendance Certificate At the end of the Congress an attendance certificate will be given to all registered Participants. Audiovisual Equipment PC projection (only POWER POINT file on CD or on a memory stick, USB port or DVD, it is not possible to use Macintosh computer) will be provided in the Meeting room. Speakers are kindly requested to contact the Slide Centre to upload their presentation(s) and to test all the audiovisual material at least one hour before the lecture. Due to the several foreign guests all slides must be in English. 11

General Information Meeting Venue Teatro Signorelli P.zza Signorelli - 52044 Cortona (AR - Italy) Tel/Fax +39 0575 601882 www.teatrosignorelli.com - info@teatrosignorelli.com How to reach Cortona The closest airport is Florence, but for continental flights is Rome. Cortona can be easily reached either by car or by train, being served by the Autostrada del Sole (Valdichiana exit), State Road SS 71 and the Milan-Florence-Rome railway. By train: Direct train Milan-Firenze-Roma (see time tables for Rome-Cortona and Milan- Cortona connections: Terontola-Cortona railway station (194 km from Rome, 122 km from Florence) or Camucia-Cortona railway station. The Terontola station is 11 km from Cortona and the Camucia station is 5 km from Cortona. There is a bus service to Cortona from both stations. By car: Autostrada del Sole (State Highway green on the map above):"valdichiana" Exit. Upon exiting the highway, take the Siena-Perugia State Road and continue towards Perugia. There are 3 possible turn-offs for Cortona: Cortona via Manzano, Cortona via Laurentana and Cortona via Strada Statale 71 (State Road 71). In this latter case, at Camucia there is a deviation for Cortona and Città di Castello (the Umbran-Cortonese Province Road). 12

Registration Fees Members SINch & AANS/CNS 250,00 Non Members 320,00 Trainees 150,00 Fees include: Congress material, Welcome reception, coffee breaks and lunches Registration cancellation policy No refund of cancellation of registration fees. Substitutions in writing will be accepted at any time. Hotel reservation The Organizing Secretariat reserved a certain number of rooms for participants. Reservations will be accepted on a first-come-first-served basis. For information contact: CSR Congressi srl - Via Matteotti 35 40057 Cadriano di Granarolo E. (BO), Italy Tel. +39 051 765357 - Fax +39 051 765195 - E-mail: info@csrcongressi.com Sponsorships and exhibition An exhibition will be held during the Congress. To become an exhibitor, contact the Organizing Secretariat, CSR Congressi, info@csrcongressi.com How to register and how to pay Registration Form (available on the website www.csrcongressi.com) to be filled out and faxed back (+39 051 765195) or sent by e-mail together with copy of payment to the Organizing Secretariat: CSR Congressi srl - info@csrcongressi.com All payments must be made in (Euro) only, net of all bank charges as follows: cheque, eurocheque, made payable to: CSR Congressi Srl Bologna Italy credit card VISA, EUROCARD, MASTERCARD All payments made by credit card will be debited in (Euro) Bank Transfer made to the order of the following account In favour of: CSR Congressi srl Bank: BANCA DI CREDITO COOPERATIVO DI CASTENASO Address: Via Due Agosto 1980, n. 45/D 40057 Cadriano di Granarolo Emilia (BO) Italy IBAN: IT26R0847236850000000085110 SWIFT/BIC Code: ICRAITMMD 40 13

All charges due on bank transfer must be paid by the sender. Please indicate the name, the address of the person(s) registering for the Meeting and the title of the Meeting clearly on the transfer. A copy of bank transfer must be sent together with the Registration Form. A receipt of payment for the total amount will be issued directly by CSR Congressi. No registration will be processed unless accompanied by payment. Written confirmation will be sent by the Organizing Secretariat. Deadline for registration is June 21 st, 2010 After this date registrations will only be accepted at the Meeting Venue. Privacy Information according to Legislative Decree no. 196/2003. Your personal data, that you voluntarily provided on this occasion and that have been collected by CSR Congressi, shall be processed either manually or with the help of electronic and/or automated means, for the following purposes: filing your participation in Congresses, Conferences, Meetings and other Events organized by CSR Congressi; complying with law obligations. Your data shall be communicated to suppliers and third parties involved or participating in the Event organized as well as to relevant public authorities, in compliance with law provisions. The nature of providing the requested data for the purposes listed above is compulsory for your participation in the Event. The data controller is CSR Congressi, whose head office is in Via Matteotti 35, 40057 Cadriano di Granarolo E. BO, Italy. As a data subject, you shall exert all the rights provided for by Title II of Legislative Decree no. 196/2003. By signing the Intent Form you declare that you read the information provided and you give your consent to the processing and communication of your personal data for the purposes listed above. 14 Organized by CSR Congressi Srl Via G. Matteotti, 35-40057 Cadriano di Granarolo E. (BO) Tel. 051 765357 Fax 051 765195 info@csrcongressi.com - www.csrcongressi.com Certified CERMET UNI EN ISO 9001-2008 No. 1036-A

Brain Tumor Symposium Cortona (AR), Italy - July 2-4, 2010 Cod. X16 REGISTRATION FORM To be completed in block letters and mailed with payment receipt to: CSR Congressi srl - Via Matteotti 35-40057 Cadriano di Granarolo E. (BO), Italy Tel. +39 051 765357 - Fax +39 051 765195 - E-mail: info@csrcongressi.com Last deadline for registration at CSR Congressi: June 21 st, 2010 After this date registrations will only be accepted at the Meeting Venue. Name Family name Home Address Post Code City Country Priv. Tel. Priv. Fax e-mail Mobile Institute Department Position Address Post Code City Country Tel. COMPULSORY FOR ALL PARTICIPANTS Invoice to Fax Address Zip Code City Country Tax No. FOR ITALIAN PARTICIPANTS ONLY: RISERVATO ALLE SOLE AZIENDE OSPEDALIERE Richiesta di esenzione IVA (art. 10 comma 20 D.P.R. 633/72) Gli Enti Pubblici che desiderino richiedere l esenzione IVA sul pagamento della quota d iscrizione di dipendenti sono tenuti a farne specifica richiesta barrando e apponendo il proprio timbro nello spazio di seguito riportato. Non sono fiscalmente riconosciute richieste senza timbro. VAT No. timbro dell Ente che fa richiesta di esenzione IVA REGISTRATION FEES (VAT INCLUDED) Members SINch & AANS/CNS 250,00 Non Members 320,00 Trainees 150,00 Fees include: Congress material, Welcome reception, coffee breaks and lunches PAYMENT SUMMARY: REGISTRATION FEE TOTAL PAYMENT HOTEL RESERVATION The Organizing Secretariat reserved a certain number of rooms for participants. Reservations will be accepted on a first-come-first-served basis. For information contact: CSR Congressi srl - Via Matteotti 35-40057 Cadriano di Granarolo E. (BO), Italy Tel. +39 051 765357 - Fax +39 051 765195 - E-mail: info@csrcongressi.com PAYMENT SYSTEM: CREDIT CARD The undersigned Authorizes payment of the above amount of VISA EUROCARD MASTERCARD CARD NUMBER EXPIRY DATE SECURITY CODE Issued to Non endorsable bank cheque or banker s draft made out to CSR CONGRESSI SRL Bank N Bank transfer, free of bank charges, made out to CSR CONGRESSI SRL Bank: BANCA DI CREDITO COOPERATIVO DI CASTENASO Address: VIA DUE AGOSTO 1980, N. 45/D 40057 CADRIANO DI GRANAROLO EMILIA (BO) - ITALY IBAN: IT26R0847236850000000085110 SWIFT/BIC Code: ICRAITMMD 40 Reason for payment: Registration 9 th International Meeting UPDATES IN NEURO-ONCOLOGY - Cod X16. Please, attach payment receipt copy to Registration Form. I hereby authorize the processing of my personal data in compliance with D. Lgs. 30/06/2003 N 196 on personal data handling only for this Course management. Signature Date