EUROPEAN MULTIDISCIPLINARY SYMPOSIUM



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5 th EUROPEAN MULTIDISCIPLINARY SYMPOSIUM on Liver-Directed Cancer Therapy using 90Y Microspheres RoME (Italy) 7th- 8th February 2014 Rome Cavalieri Hotel Final Programme

Local Steering Committee Roberto Cianni Enrico Cortesi Giuseppe Maria Ettorre Alfredo Falcone Rita Golfieri Carlo Ludovico Maini Faculty Scientific Information Hojjat Ahmadzadehfar Nuclear Medicine, Universitätsklinikum Bonn, Bonn (Germany) Adil Al-Nahhas Nuclear Medicine, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London (United Kingdom) Dirk Arnold Medical Oncology, Klinik für Tumorbiologie, Freiburg (Germany) Irene Bargellini Diagnostic and Interventional Radiology, Azienda Ospedaliero-Universitaria Pisana, Pisa (Italy) José Ignacio Bilbao Radiology, Clínica Universidad de Navarra, Pamplona (Spain) Digestive Diseases and Internal Medicine, Azienda Ospedaliero-Universitaria di Bologna Policlinico Sant Orsola-Malpighi, Bologna (Italy) Christiane Bruns Surgery, Otto-von-Guericke-Universität, Magdeburg (Germany) Roberto Cianni Interventional Radiology, Ospedale Santa Maria Goretti, Latina (Italy) Enrico Cortesi Medical Oncology, Sapienza Università di Roma, Roma (Italy) Maurizio Cosimelli General and Hepato-Biliary-Pancreatic Surgery, Istituto Nazionale Tumori Regina Elena, Roma (Italy) Marta Cremonesi Medical Physics, Istituto Europeo di Oncologia, Milano (Italy) Giuseppe Maria Ettorre General Surgery and Liver Transplantation, Azienda Ospedaliera San Camillo-Forlanini e L. Spallanzani, Roma (Italy) Alfredo Falcone Oncology, Università di Pisa, Pisa (Italy) Patrick Flamen Nuclear Medicine, Institut Jules Bordet, Brussels (Belgium) Andrea Frilling Surgery, Hammersmith Campus, Imperial College London, London (United Kingdom) Bernhard Gebauer Interventional Radiology, Charité - Universitätsmedizin Berlin, Berlin (Germany) Rita Golfieri Radiology, Azienda Ospedaliero-Universitaria di Bologna Policlinico Sant Orsola-Malpighi, Bologna (Italy) Volker Heinemann Medical Oncology, Comprehensive Cancer Center der LMU, Klinikum der Universität München, München (Germany) Jörg C. Kalff Surgery, Universitätsklinikum Bonn, Bonn (Germany) Andrew Kennedy Radiation Oncology, Sarah Cannon Research Institute, Nashville (USA) Frank T. Kolligs Internal Medicine, Universität München, München (Germany) Suzanne Lindley YES Beat Liver Tumors, Dallas (USA) Carlo Ludovico Maini Nuclear Medicine, Istituto Nazionale Tumori Regina Elena, Roma (Italy) Geert Maleux Radiology, University Hospital Leuven, Leuven (Belgium)

Peter Malfertheiner Gastroenterology, Hepatology and Infectious Diseases, Universitätsklinikum Magdeburg A.ö.R., Magdeburg (Germany) Derek Manas Hepato-Pancreato-Biliary and Transplant Surgery, University of Newcastle Upon Tyne and NHS Trust, Newcastle Upon Tyne (United Kingdom) Gianluca Masi Medical Oncology, Azienda Ospedaliero-Universitaria Pisana, Pisa (Italy) Marc Peeters Oncology, Antwerp University Hospital, Edegem (Belgium) Vikas Prasad Nuclear Medicine, Charité - Universitätsmedizin Berlin, Berlin (Germany) olivier Rosmorduc Hepatology, Hôpital Saint-Antoine, Paris (France) Fernando Rotellar Surgery, Clínica Universidad de Navarra, Pamplona (Spain) Bruno Sangro Hepatology, Clínica Universidad de Navarra, Pamplona (Spain) Niklaus G. Schaefer Medical Oncology and Nuclear Medicine, UniversitätsSpital Zürich, Zürich (Switzerland) Michael R. Schön Surgery, Städtisches Klinikum Karlsruhe, Karlsruhe (Germany) Ricky Sharma Radiation Oncology, University of Oxford, Oxford (United Kingdom) Alberto Sobrero Medical Oncology, I.R.C.C.S. Azienda Ospedaliera Universitaria San Martino, Genova (Italy) Brian Stedman Interventional Radiology, University Hospital Southampton NHS Trust, Southampton (United Kingdom) Lidia Strigari Medical Physics, Istituto Nazionale Tumori Regina Elena, Roma (Italy) Julien Taieb Gastroenterology, Hôpital Européen Georges-Pompidou, Paris (France) Juan Valle Medical Oncology, The University of Manchester/ The Christie NHS Foundation Trust, Manchester (United Kingdom) Eric Van Cutsem Digestive Oncology, University Hospital Gasthuisberg/Leuven, Leuven (Belgium) Maurice van den Bosch Interventional Radiology, University Medical Centre Utrecht, Utrecht (The Netherlands) Chris Verslype Hepatology and Digestive Oncology, University Hospital Gasthuisberg/Leuven, Leuven (Belgium) Valérie Vilgrain Radiology, Hôpital Beaujon, Clichy (France) Medical Oncology, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London (United Kingdom) CME/ECM accreditation The 5 th European Multidisciplinary Symposium on Liver-Directed Cancer Therapy using 90Y Microspheres has been granted with 9 European CME credits (ECMEC) by the European Accreditation Council for Continuing Medical Education (EACCME) and with 14 Italian ECM credits by MCC srl, Provider n. 1726, event n. 1726-82455.

Friday 7 th February 2014 8.30 Welcome address on behalf of the Local Steering Committee 8.35 Introduction The burden of liver tumours SIRT within the HCC multidisciplinary team Chairmen:, Valérie Vilgrain 8.45 State of the art - hepatocellular carcinoma (HCC) 9.05 Evidence based integration of SIRT into HCC management Bruno Sangro 9.25 Clinical studies Valérie Vilgrain PRoGRAMME 9.40 Case study presentations with interactive questions and panel discussion Panellists: Frank T. Kolligs, Peter Malfertheiner, Derek Manas, Vikas Prasad, Bruno Sangro, Chris Verslype HCC with large tumour volume (poor candidate for TACE) Peter Malfertheiner HCC with PVT Chris Verslype HCC failed TACE Frank T. Kolligs 10.45 Coffee break SIRT within the colorectal/ liver multidisciplinary team Chairmen: Alfredo Falcone, Eric Van Cutsem 11.00 State of the art - colorectal liver metastases (CLM) Alberto Sobrero 11.20 Evidence based integration of SIRT into CLM management 11.40 Clinical studies Volker Heinemann 11.55 Case study presentations with interactive questions and panel discussion Panellists: Adil Al-Nahhas, Volker Heinemann, Marc Peeters, Michael R. Schön, Ricky Sharma, Alberto Sobrero, Julien Taieb, Maurice van den Bosch, Consolidation treatment for patient after 1 st -line chemo Marc Peeters Second-line therapy Ricky Sharma Chemotherapy refractory treatment Julien Taieb 13.15 Lunch SIRT - Downsizing and downstaging to resection and transplantation Chairmen: Giuseppe Maria Ettorre, Jörg C. Kalff 14.15 The evidence of resection post-sirt Christiane Bruns 14.35 The safety of resection post-sirt Fernando Rotellar

14.55 Liver function considerations post-sirt resection (HCC & mcrc) Bruno Sangro 15.10 Bridging and downstaging to transplantation in HCC Giuseppe Maria Ettorre 15.30 Hypertrophy in the contralateral lobe post SIRT Derek Manas 15.50 Discussion 16.00 From survivorship to advocacy Suzanne Lindley 16.20 Coffee break SIRT - State of the art for interventional radiologists and nuclear medics Chairmen: Roberto Cianni, Carlo Ludovico Maini 16.40 Latest SIRT recommendations from EU proctors Geert Maleux 17.00 optimising the use of PET with SIRT Patrick Flamen 17.20 SIRT dosimetry Andrew Kennedy 17.40 Panel discussion Panellists: Hojjat Ahmadzadehfar, Marta Cremonesi, Patrick Flamen, Bernhard Gebauer, Andrew Kennedy, Geert Maleux, Lidia Strigari 18.00 Conclusion of the first Symposium day SIRT for other liver tumours Chairmen: Rita Golfieri, Niklaus G. Schaefer 8.45 Evidence based integration of SIRT into the management of: 8.45 NET liver metastases Andrew Kennedy 9.15 Cholangiocarcinoma Olivier Rosmorduc 9.35 Breast cancer liver metastases Roberto Cianni 9.55 Ocular melanoma liver metastases Brian Stedman 10.15 Panel discussion Panellists: Roberto Cianni, Andrea Frilling, Andrew Kennedy, Olivier Rosmorduc, Brian Stedman, Juan Valle 10.50 Coffee break SIRT and other modalities for liver tumours Chairmen: José Ignacio Bilbao, Enrico Cortesi 11.05 Cost of SIRT vs other modalities 11.25 How does SIRT compare with and/or complement other liver-directed therapies? Irene Bargellini 11.45 How can we optimally combine and sequence SIRT with chemotherapy and biological therapies? Dirk Arnold 12.05 Panel discussion Panellists: Dirk Arnold, Irene Bargellini, Maurizio Cosimelli, Gianluca Masi, 12.45 Take Home Messages 13.00 Final remarks Saturday 8 th February 2014

Hotel Accommodation For any service related to the accommodation your main contact will be the Organizing Secretariat MCC. Congress Reception opening Hours organizing Secretariat Thursday 6 February 2014 Registration th 16.00-19.00 Friday 7th February 2014 8.00-18.00 Saturday 8th February 2014 8.00-14.00 MCC srl Viale A. Oriani, 2-40137 Bologna (Italy) Tel. +39 051 263703 - Fax +39 051 238564 sirtsymposium@mccstudio.org www.sirtsymposium.com Company with Certified Quality Management System ISO 9001:2008 In cooperation with General Information Meeting Venue Rome Cavalieri Hotel Via Alberto Cadlolo, 101 - Rome (Italy)