Consensus conference on salivary gland tumors

Transcription

1 Consensus conference on salivary gland tumors Adenoid-cystic carcinoma and high-grade neoplasms A common commitment towards the future October 23rd-24th 2014, School of Medicine, University of Brescia (Italy)

2 Consensus conference on salivary gland tumors Adenoid-cystic carcinoma and high-grade neoplasms Dear Colleagues, The challenging management of salivary gland malignancies asks for a multidisciplinary approach. In the last few years the knowledge in the field of basic science has grown rapidly, and is probably becoming the driver for therapeutic choices in the future. In keeping with this concept, the present conference wants to gather experts in the fields of Pathology, Imaging, Surgery (ENT and Maxillo-Facial Surgeons), Radiation and Medical Oncology to prepare for the future. Together we will delineate by consensus the management of problematic salivary gland tumors for the next years. This will be a 2-day consensus conference, with the first day dedicated to adenoid-cystic carcinoma, and the second day focused on high-grade salivary gland malignancies. Three topics for discussion (diagnosis, therapeutic approach to the primary lesion, treatment of recurrent/metastatic disease) will characterize each day of the meeting. Each session will consist of two parts: in the first, the state of the art will be defined by experts, whereas in the second part the panelists and audience will try to reach a consensus. For each topic (diagnosis, treatment of primary tumor and metastatic disease), a chairman and experts will be identified. They will be in charged of writing a document that will be submitted to the panelists for comments, at least 6 months before the date of the meeting. The final document will be discussed during the meeting between experts and the audience to reach a consensus.

3 Congress Directors Adel El-Naggar, Department of Pathology, M.D. Anderson Cancer Center, Houston, USA Ehab Hanna, Department of Head and Neck Surgery, M.D. Anderson Cancer Center, Houston, USA Lisa Licitra, Head and Neck Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy Roberto Maroldi, Department of Radiology, University of Brescia, Italy Piero Nicolai, Department of Otorhinolaryngology, University of Brescia, Italy Scientific Secretariat Laura Locati, Head and Neck Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy Davide Lombardi, Department of Otorhinolaryngology, University of Brescia, Italy Ester Orlandi, Department of Radiation Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy William Vermi, Department of Pathology, University of Brescia, Italy

4 Faculty International Faculty Ian Casselman, Department of Radiology, A.Z. St.-Jan Hospital, Bruges, Belgium Jurgen Debüs, Department of Radiation Oncology, University of Heidelberg, Germany Isabel Fonseca, Department of Head Neck Pathology, University of Lisbon, Portugal David G. Pfister, Head and Neck Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, USA Goran Stenman, Department of Pathology, Sahlgrenska Cancer Center, University of Göteborg, Sweden Carla M. van Herpen, Department of Medical Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands Vicent Vander Poorten, Department of Head Neck Surgery, University of Leuwen, Belgium Philippe Vielh, Department of Pathology, Institut Gustave Roussy, Paris, France Randal Weber, Department of Head Neck Surgery, Houston, USA

5 Faculty Italian Faculty Mario Airoldi, Department of Medical Oncology, University of Turin Antonino R. Antonelli, Department of Otorhinolaryngology, University of Brescia Alfredo Berruti, Department of Medical Oncology, University of Brescia Francesco Bertagna, Department of Nuclear Medicine, University of Brescia Mario Bussi, Department of Otorhinolaryngology, University S.Raffaele, Milan Flavio Crippa, Nuclear Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan Fabio Facchetti, Department of Pathology, University of Brescia Carlo Fallai, Department of Radiation Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan Davide Farina, Department of Radiology, University of Brescia Piero Fossati, Department of Radiation Oncology, National Center for Adrotherapy CNAO, Milan Raffaele Giubbini, Department of Nuclear Medicine, University of Brescia Gioacchino Giugliano, Department of Head and Neck Surgery, Istituto Europeo di Oncologia, Milan Marco Guzzo, Head and Neck Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan Stefano Magrini, Department of Radiation Oncology, University of Brescia Ugo Pastorino, Thoracic Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan Cesare Piazza, Department of Otorhinolaryngology, University of Brescia Paolo Potepan, Department of Head and Neck Radiology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan Giuseppe Sanguineti, Department of Radiation Oncology, National Cancer Institute Regina Elena, Rome Enrico Sesenna, Department of Maxillofacial Surgery, University of Parma Giuseppe Spriano, Department of Head and Neck Surgery, National Cancer Institute Regina Elena, Rome Barbara Valeri, Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan

6 Program Introduction: P. Nicolai Honorary lecture: The history of adenoid-cystic carcinoma A. R. Antonelli Day 1, October 23rd 2014: Adenoid-cystic carcinoma (ACC) Lecture: Overview on molecular features of ACC and their impact on treatment. (A. El-Naggar) (20 ) st Session: DIAGNOSIS Chairman: A. El-Naggar Panelists: I. Casselman, F. Crippa, F. Facchetti, B. Valeri - Histopathologic definition, histologic subtypes and aggressive variants (G. Stenman) (15 ) - FNAB and histology: the most frequent missclassifications (I. Fonseca) (10 ) - Overview on perineural spread: cellular and molecular mechanisms (W. Vermi) (10 ) - The role and limits of imaging (CT, MRI, and PET) in treatment planning (R. Maroldi- R. Giubbini) (20 ) Consensus on: - Histopathologic diagnostic criteria - Diagnostic imaging Coffee-break

7 Day 1, October 23rd nd Session: TREATMENT OF THE PRIMARY LESION Chairman: V. Vander Poorten Panelists: P. Fossati, G. Giugliano, S. Magrini, L. Licitra, D. Lombardi - Indications, suggestions and problems in surgical treatment of minor salivary glands adenoid-cystic carcinoma (P. Nicolai) (15 ) - Indications, suggestions and problems in surgical treatment of major salivary glands adenoid-cystic carcinoma (E. Hanna) (15 ) - Reconstructive issues and facial reanimation (C. Piazza, E. Sesenna) (20 ) - Indications to RT in an adjuvant and exclusive setting (+/- CHT) (E. Orlandi) (20 ) - Carbon-ion therapy (J. Debüs) (20 ) Consensus on: - Treatment of the primary lesion - Reconstruction and facial reinnervation - Adjuvant and curative RT +/- CHT Lunch rd Session: FOLLOW-UP AND RECURRENT/METASTATIC DISEASE Chairman: R. Weber Panelists: E. Hanna, E. Orlandi, M. Airoldi, D. Farina, F. Bertagna - The role of imaging (CT, MRI and PET) in the post-treatment surveillance (I. Casselman) (15 ) - The role of surgery in the treatment of local relapse (V. Vander Poorten) (15 ) - The role of reirradiation in the treatment of local relapse (C. Fallai) (15 ) - The role of surgery in the treatment of lung metastasis (U. Pastorino) (10 ) - Therapy for locally advanced, recurrent and metastatic disease (D. G. Pfister) (20 ) Consensus on: - Follow-up strategy - Indications for surgery and/or reirradiation for recurrent primary lesions - Indications for surgery for lung metastases - Medical treatment for metastatic disease

8 Day 2, October 24th 2014: High-grade salivary gland tumors (High-grade MEC, Salivary duct carcinoma, Carcinoma ex-pleomorphic adenoma, Adenocarcinoma) Lecture Overview on molecular features of high-grade salivary gland tumors and their impact on treatment (A. El-Naggar) (20 ) st Session: DIAGNOSIS Chairman: F. Facchetti Panelists: I. Casselman, R. Giubbini, A. El-Naggar, B. Valeri - Chromosomal rearrangements and fusion oncogenes (G. Stenman) (20 ) - The role of FNA in diagnosis and molecular testing of salivary gland cancers (P. Vielh) (15 ) - Histopathologic definition and differential diagnosis (I. Fonseca) (15 ) - The role and limits imaging (CT, MRI and PET) in treatment planning (D. Farina - F. Crippa) (15 ) Consensus on: - Histopathologic diagnostic criteria - Diagnostic imaging Coffee-break nd Session: TREATMENT OF THE PRIMARY LESION AND THE NECK Chairman: M. Bussi Panelists: M. Guzzo, J. Debüs, A. Berruti, L. Locati - Indications, suggestions, and problems in surgical treatment of high-grade salivary gland tumors (V. Vander Poorten) (15 ) - Indications, suggestions, and problems in surgical treatment of the neck in high-grade salivary glands tumors (G. Spriano) (15 ) - Indications for RT in an adjuvant and exclusive setting (+/- CHT) (G. Sanguineti) (20 )

9 Day 2, October 24th Consensus on: - Surgical indications for the treatment of primary lesions and the neck - Indications for adjuvant treatment and exclusive RT (+/-ChT) Lunch rd Session: FOLLOW-UP AND RECURRENT/METASTATIC DISEASE Chairman: L. Licitra Moderators: E. Hanna, C. Fallai, R. Maroldi/D. Farina, F. Bertagna - The role of imaging in the post-treatment surveillance (P. Potepan - F. Crippa) (15 ) - The role of surgery in the treatment of loco-regional relapse (R. Weber) (15 ) - The role of reirradiation in the treatment of loco-regional relapse (S. Magrini) (15 ) - Systemic therapy for locally advanced, recurrent and metastatic disease (C. M. Van Herpen) (15 ) Consensus on: - Follow-up strategy - Indications to surgery and/or re-irradiation for recurrent primary lesions - Systemic treatment for metastatic disease Closing remarks

10 General informations Language ECM/CME The official language will be English. The course will ECM and CME accredited. Hotel booking For information and booking please contact the Organizing Secretariat. Course Venue School of Medicine - University of Brescia Via Valsabbina, Brescia - Italy Insurance Organizers do not accept responsability for individual medical, travel or personal expenses. Registrants are strongly advised to take out their own personal insurance policies. Cancellation Policy In the unusual circumstance that the course is cancelled, two weeks notice will be given and the fee will be refunded in full. The Organizers are not responsible for any airfare, hotel or other costs incurred. Organizing Secretariat Servizi C.E.C. Srl - Via G. Verdi, Bergamo - Italy Phone +39.(0) Fax. +39.(0) [email protected] How to reach the University of Brescia-School of Medicine By car Highway A4 Milano-Venezia. Exit Brescia Ovest; at the exit follow Tangenziale Ovest proceed along Tangenziale Nord. Follow for Stadio or Ospedale, proceed along via Oberdan. Go through, turn left for Via Triumplina and after 800 mt. turn right through Via Branze, on your left there s the School of Engineering and on the right hand there is School of Medicine. Exit Brescia Centro; at the exit take the Tangenziale Sud follow the road signs that take to Tangenziale. Please follow the one with Val Trompia, Milano or Bergamo. Arrived in the Tangenziale, proceed along till the road sign Tangenziale Ovest or Val Trompia. Now drive thorugh Tangenziale Ovest and go ahead to Tangenziale Nord, follow the road signs Stadio or Ospedale. Keep driving on via Oberdan till the end, then turn left on Via Triumplina and after 800 mt. turn right through Via Branze, on your left there s the School of Engineering and on the right hand there is School of Medicine. By Train You can reach the School of Medicine via bus, subway or taxi By Taxi The taxi stand is just outside the train station. By Bus Line 1: direction Mompiano, bus stop via Schivardi. Line 15: direction Villaggio Montini, bus stop Viale Europa, corner via Branze. By Tube Blue line, stop at Europa Parking Closed to the School of Medicine there are: Parcheggio Ospedale Nord and Parcheggio Ospedale Sud. October 23rd-24th 2014, School of Medicine, University of Brescia (Italy)

11 Registration form Please, fill in this form and return it to Servizi C.E.C. Srl: by fax by mail First name (s) Surname Date of birth Profession Discipline Ph. number address Home address Birthplace Mobile Zip code City Country Institute/Hospital Department Work address Zip code City Country Pursuant to Italian Legislative Decree no. 196/03 (Privacy law), Servizi C.E.C. s.r.l. - Via Verdi, Bergamo - Italy is responsible for the processing and collection of personal data. You are free to conferm or deny this right but these data are necessary to supply the services required. You may address Servizi C.E.C. s.r.l. for the treatment and exert your rights pursuant to article 7 of the Italian Legislative Decree no. 196/03 (access, correction, cancellation, etc.). Date Signature Registration fee Full 610,00 VAT included Resident 305,00 VAT included (*) (*) must be accompanied by a letter from the applicant s chief confirming the Resident status. Please send this confirmation by to [email protected] Registrations must be sent to Organizing Secretariat completing the form accompanied by the payment of the fee. The registration fee includes: entrance to the course, course materials, certificate of attendance, coffee breaks, lunches. October 23rd-24th 2014, School of Medicine, University of Brescia (Italy)

12 How to pay BANK TRANSFER Please fax a copy of the bank transfer to the Organizing Secretariat. Account name: SERVIZI C.E.C. S.r.l. Bank name: Credito Bergamasco IBAN code: IT96 E Swift code: CREBIT22 CREDIT CARD Please fill in every line (write in capital letters), sign it and fax it to the Organizing Secretariat. VISA Mastercard Cardholder s name Card number Card valid from (day/month/year) I authorize Servizi C.E.C. S.r.l. to deduct the fee from my credit card Signature to Invoice headed to Address Zip code City Country C.F. * P.I. ** * Only for Italian and EU participants. ** Only for Italian and EU participants. PLEASE NOTE Only after receiving the payment and processing the request, the Organizing Secretariat will send you a confirmation letter in order to confirm your registration. Bank charges are the responsibility of the participant and should be paid at source in addition to the registration fee Registration fee includes VAT taxes Only Euro ( ) are accepted Requests by phone are not accepted Cancellations/refunds/changes If a written request is received before August 29th, 2014 a 75% refund will be allowed. After August 30tht, 2014 no refund is due. All refunds will be handled after the course and bank charges will be retained by the Organizing Secretariat. No shows will not be refunded. Name changes are accepted at any time and do not incur any additional fee. I accept these conditions. October 23rd-24th 2014, School of Medicine, University of Brescia (Italy)

13 Consensus conference on salivary gland tumors Adenoid-cystic carcinoma and high-grade neoplasms Organizing Secretariat Servizi C.E.C. Srl Via Verdi, Bergamo - Italy Tel Fax Mob [email protected]