15 th ASEICA INTERNATIONAL CONGRESS

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1 Sevilla october th ASEICA Spanish Society for Cancer Research Hotel NH Collection Sevilla. Avda Diego Martinez Barrio, 8, Sevilla

2 Organizing Committee President Dr. Pedro Lazo-Zbikowski Dr. Carlos Camps Dr. Noemí Reguart Dr. Gabriel Capellá Dr. Montserrat Sánchez Cespedes Dr. Luis Paz-Ares Dr. Ana Osorio Dr. Arkaitz Carracedo Dr. Jesús Paramio Dr. José Palacios Scientific Committee Dr. Pedro Lazo-Zbikowski Dr. Carlos Camps Dr. Gabriel Capellà Dr. Arkaitz Carracedo Dr. Leonor David Dr. Antonio García de Herreros Dr. Alberto Muñoz Dr. Ana Osorio Dr. José Palacios Dr. Jesús Paramio Dr. Luis Paz-Ares Dr. Héctor Peinado Dr. Noemí Reguart Dr. Montse Sánchez-Céspedes Dr. Joan Seoane Dr. Violeta Serra Dr. George Thomas Dr. Guillermo Velasco

3 15 th ASEICA Wednesday 21 st october Meeting opening Opening conference. ASEICA Lecture Targetting telomeres in cancer Dr. María A. Blasco, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid A. Sustaining proliferative signaling & evading growth suppressors Chairpersons Dr. Jesús Paramio and Dr. Violeta Serra Linking senescence and inflammation: the senescence-associated secretory phenotype (SASP) Dr. Jesús Gil, MRC Clinical Science Center, Kings College, London, UK Targeting PI3K in breast cancer Dr. Violeta Serra, Hospital Universitari Vall d Hebrón (VHIO), Barcelona Tyrosine kinase inhibitors: from Lazarians responses to the emergence of resistance. A focus in lung cancer Dr. Luis Paz-Ares, Hospital Universitario 12 de Octubre, Madrid Determination of the proto-oncogenic role of pim1/pim2 kinases in male reproductive system tumors by using conditional transgenic murine models Manuel Pedro Jiménez García, Instituto de Biomedicina de Sevilla (IBIS)

4 15 th ASEICA A syntethic lethal screen identifies usp39 as an essential gene for krasdependent cancers Julia Martínez Fraile, Universidad de Oviedo Coffee break and poster viewing B. Cancer genomics and tumor heterogeneity Chairpersons Dr. Montse Sánchez-Céspedes and Dr. José Palacios Novel gene alterations and biological networks in lung cancer development Dr. Montse Sánchez-Céspedes, Instituto de Investigación Biomédica de Bellvitge (IDIBELL), Barcelona Genomic characterization of the role of intratumor heterogeneity in cancer progression and metastasis Dr. Ignacio Varela, Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC - UC - CSIC - SODERCAN), Santander Clinical implications of intrinsic breast cancer subtypes Dr. Aleix Prat, Hospital Universitari Clínic, Barcelona Identification of markers of endometrial cancer in exosome-like vesicles of uterine fluids using a super silac quantitative proteomics approach Eva Colas, IRB Lleida Yes1 kinase is a new therapeutic target in non-small cell lung cancer Irati Garmendia, Centro de Investigación Médica Aplicada, Pamplona

5 Round table: clinical applications of genomics Chairperson Dr. Luis Paz-Ares Clonal evolution and drug resistance: from cancer avatars to liquid biopsies Dr. Manuel Hidalgo, Centro de Investigaciones Oncológicas (CNIO), Madrid Discussants: Dr. Manuel Hidalgo, Centro de Investigaciones Oncológicas (CNIO), Madrid Dr. Joan Albanell, Hospital del Mar-Parc de Salut Mar, Barcelona Dr. Alfonso Berrocal, Hospital General Universitario, Valencia Thursday 22 nd october C. Metabolism. Deregulating cellular energetics Chairpersons Dr. George Thomas and Dr. Arkaitz Carracedo Ribosome biogenesis mediates a novel intrinsic p53 checkpoint in cancer progression Dr. George Thomas, Instituto de Investigación Biomédica de Bellvitge (IDIBELL), Barcelona Nutrient Sensing Pathway in cancer Dr. Nabil Djouder, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid Metabolic alterations as biomarkers of efficacy in anticancer therapies targeting the PI3K/AKT/mTOR pathway Dr. Jordi Rodón, Hospital Universitari Vall d Hebrón (VHIO), Barcelona

6 15 th ASEICA Metabolic reprogramming as an escape mechanism against treatment with multi-tyrosine kinase inhibitors Dr. Miguel Quintela, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid Transcriptional regulation of prostate cancer metabolism Verónica Torrano Moya, CICbioGUNE, Vizcaya Tanyrase inhibition blocks wnt/β-catenin pathway and reverts resistance to pi3k and akt inhibitors in colorectal cancer treatment Oriol Arqués, VHIO, Barcelona Coffee break and poster viewing D. Resisting cell death Chairpersons Dr. Guillermo Velasco and Dr. Gabriel Capellà Signaling mechanisms involved in the regulation of autophagy-mediated cancer cell death Dr. Guillermo Velasco, Universidad Complutense de Madrid, Instituto de Investigaciones Santarias San Carlos, Madrid The two faces of mesenchymal stem cells in myeloid neoplasias Dr. Simón Méndez-Ferrer, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid Cell death induced by inhibition of glucose metabolism Dr. Cristina Muñoz-Pinedo, Instituto de Investigación Biomédica de Bellvitge (IDIBELL), Barcelona

7 Fadd phosphorylation is altered in t-cell lymphoblastic lymphoma. José Luis Marin Rubio, CBMSO (UAM/CSIC), Madrid Increased expression of gasdermin-b (gsdmb) associates with resistance to anti-her2 therapies in her2+ breast cancer David Sarrió, Universidad Autonóma de Madrid, Madrid SATELLITE SYMPOSIUM Sponsorized by Immunology; a new opportunity on cancer Chairperson Dr. Luis Paz-Ares, Hospital Universitario 12 de Octubre, Madrid Dr. Carlos Camps, Hospital General Universitario de Valencia Bienvenida Systematization, hierarchies and dependencies on immune system. Immune checkpoint inhibitors: Clinical results and future Dr. Alfonso Berrocal, Hospital General Universitario, Valencia Immunoscores in cancer: a possible goal to achieve? Dr. Ignacio Duran, Hospital Virgen del Rocío, Sevilla How recent advances in immunotherapy are changing the standard of care for patients with metastatic melanoma Dr. Luis de la Cruz, Hospital Universitario Virgen Macarena, Sevilla Immunotherapy for lung cancer: recent advances, lessons learned, and areas for further research Dr. Luis Paz-Ares, Hospital Universitario 12 de Octubre, Madrid Open discussion

8 15 th ASEICA Lunch Poster session with presenters (odd numbers from to 15.00h, even numbers from to 16.00h) E. Activating invasion & metastasis Chairpersons Dr. Antonio García de Herreros and Dr. Noemí Reguart Snail1, epithelial to mesenchymal transition and fibroblast activation Dr. Antonio García de Herreros, Universidad Pompeu Fabra (UPF), Barcelona Microenviromental regulation of disseminated tumour cells dormancy Dr. Paloma Bragado, Institut d Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Barcelona Regulation of the histone demethylase LSP1 complex: implications in EMT Dr. José C. Reyes, CABIMER, CSIC-US, Sevilla Molecular mechanisms involved in peritoneal carcinomatosis of ovarian cancer Ricardo Coelho, IPATIMUP, Porto, Portugal Initiating metastatic disease in the brain: a hostile soil with key resources. Manuel Valiente, CNIO, Madrid Coffee break and poster viewing

9 F. Tumor niche and microenvironment Chairpersons Dr. Héctor Peinado and Dr. Joan Seoane Defining the role of tumor secreted exosomes during premetastatic niche formation Dr. Héctor Peinado, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid Nuevos sensores de microambiente como genes supresores Dr. Amancio Carnero, Campus Hospital Universitario Virgen del Rocío (IBIS), Sevilla The TGF-beta pathway as a therapeutic target against cancer Dr. Joan Seoane, Hospital Universitari Vall d Hebrón (VHIO), Barcelona M-trap: exosome-based capture of tumor cells as a new technology in peritoneal metastasis Rafael López, Complejo Hospitalario Univ. De Santiago de Compostela In vivo loxl2 functions in breast tumor metastasis revealed by gain-andloss-of-function mice models Alberto Martin, Universidad Autonóma, Madrid ASPIC Lecture Chairperson Dra. Leonor David The biology and functional contribution of exosomes in cancer progression and metastasis Dr. Sonia Melo, MD Anderson Cancer Center, USA and IPATIMUB-Univ. of Porto, Portugal

10 15 th ASEICA Friday 23 rd october G. Nuclear receptors, transcription and cancer Chairpersons Dr. Alberto Muñoz and Dr. Ana Osorio Targeting nuclear receptors: why we need new combinatorial therapies for breast cancer Dr. María del Mar Vivanco, CIC biogune, Vizcaya Role of the transcriptional repressor HDAC7 in leukemia and lymphoma Dr. Maribel Parra, Instituto de Investigación Biomédica de Bellvitge (IDIBELL), Barcelona Vitamin D, VDR and colon cancer Dr. Alberto Muñoz, Instituto de Investigaciones Biomédicas, CSIC-UAM, Madrid Genetic inflammation caused by nr5a2 heterozygosity is mediated by ap-1 and contributes to pancreatitis and pancreatic cancer Isidoro Cobo, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid Pushing myc inhibition towards the clinic by direct delivery of cellpenetrating peptides Marie Eve Beaulieu, Vall d Hebrón, Institute of Oncology, Barcelona Coffee break and poster viewing

11 Closing session Chairpersons Dr. Pedro A. Lazo and Dr. Carlos Camps Awards ASEICA AND EACR prizes to best communications 1 st ASEICA Young Investigator Award 1 st ASEICA Cancer Research Award Closing lectures Connecting intestinal stem cells to colorectal cancer Dr. Eduard Batlle, Institut de Recerca Biomèdica (IRB), Barcelona EACR Lecture Targeting K-Ras signaling in cancer Dr. Mariano Barbacid, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid ASEICA general assembly 15 th ASEICA Organized by With the special support of

12 SPONSORS Platinum Gold Silver Bronze Under the auspices of Accreditation requested to the Spanish System of Continuing Medical Education Accreditation granted to the European Accreditation Council for continuing Medical Education (EACCME-ACOE) for 12 European CME credits. Technical Secretariat TACTICS Passatge Batlló 15, Barcelona - Tlf: info@tacticsmd.net