14 th ASEICA INTERNATIONAL CONGRESS

Transcription

1 14 th ASEICA INTERNATIONAL CONGRESS Spanish Society for Cancer Research Madrid 23 rd -25 th September 2013 Hospital universitario Ramón y Cajal SaludMadrid Hospital Universitario Ramón y Cajal Comunidad de Madrid

2 Organizing Committee President Dr. Montse Sánchez-Céspedes Dr. Alfredo Carrato Dr. Félix Bonilla Dr. Trinidad Caldés Dr. Gabriel Capellà Dr. Pedro Lazo-Zbikowski Dr. Ana Osorio Dr. Luis Paz-Ares Dr. José Antonio Rodríguez Scientific Committee Dr. Montse Sánchez-Céspedes Dr. Alfredo Carrato Dr. Andrés Aguilera Dr. Javier Benítez Dr. Félix Bonilla Dr. Trinidad Caldés Dr. Amparo Cano Dr. Gabriel Capellà Dr. Luis Del Peso Dr. Manel Esteller Dr. Manuel Hidalgo Dr. Pedro Lazo-Zbikowski Dr. Ana Osorio Dr. Luis Paz-Ares Dr. Miguel Ángel Piris Dr. José Antonio Rodríguez Dr. Isidro Sánchez Dr. Manuel Serrano

3 MONDAY 23 rd SEPTEMBER 2013 Schedule Salón de Actos Aula Docencia 08:00_10:00h 09:00_11:00h 11:00_11:30h 11:30_12:30h 12:30_13:00h 13:00_14:30h 14:30_17:15h 17:15_17:45h 17:45_20:15h SYMPOSIUM I: Novel cancer targets and therapeutic approaches discovery LECTURE I: Drugging the cancer genome: recent discoveries with kinases and Hsp90 Opening ceremony VI RTICC ANNUAL MEETING VI RTICC ANNUAL MEETING Registration Coffee break and poster viewing Lunch and poster viewing Coffee break and poster viewing Tuesday 24 th september 2013 Schedule Salón de Actos Aula Docencia 08:30_10:30h 10:30_11:00h Symposium ii: Wide genome analysis of human cancers Coffee break and poster viewing 11:00_13:00h Symposium iii: Epigenetics and microenvironment symposium iv: Deregulation of cell metabolism in cancer development 13:00_14:00h 14:00_15:00h LECTURE II: Cancer research in the genomic era: from genes to genomes Lunch and poster viewing 15:00_17:00 SYMPOSIUM v: Cancer progression and metastasis symposium vi: Stem cells and cancer 17:00_17:30 17:30_19:30 Symposium vii: DNA damage and cancer development Coffee break and poster viewing Wednesday 25 th september 2013 Schedule Salón de Actos Aula Docencia 09:00_11:00h Symposium viii: Noncoding RNAs and cancer symposium ix: Hypoxia and angiogenesis 11:00_11:30h 11:30_13:00h 13:00_14:00h 14:00_14:30h Coffee break and poster viewing Presidential symposium Lunch and poster viewing Aseica Assembly

4 14 th ASEICA INTERNATIONAL CONGRESS MONDAY 23 rd SEPTEMBER :00_10:00 Registration 09:00_11:00 Symposium I Novel cancer targets and therapeutic approaches discovery Chairpersons Dr. Alfredo Carrato and Dr. Manuel Hidalgo New targets and therapeutic strategies in pancreatic cancer Dr. Manuel Hidalgo, Hospital de Madrid Norte Sanchinarro-CIOCC y Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid Introducing RNA therapeutics in the clinic Dr. Josep Mª Tabernero, Hospital General Universitari Vall d Hebron, Barcelona Selected oral communications *see annex 11:00_11:30 Coffee break and poster viewing 11:30_12:30 Lecture I Chairperson Dr. Josep Mª Tabernero Drugging the cancer genome: recent discoveries with kinases and Hsp90 Dr. Paul Workman, The Institute of Cancer Research, London, UK 12:30_13:00 Opening ceremony 13:00_14:30 Lunch and poster viewing

5 MONDAY 23 rd SEPTEMBER 2013 VI RTICC ANNUAL MEETING :30_15:00 Opening ceremony Dr. Antonio L. Andreu, Director General del Instituto de Salud Carlos III (ISCIII), Madrid Dr. Eugenio Santos, Coordinador Nacional de la RTICC y Centro de Investigación del Cáncer-Instituto de Biología Molecular y Celular del Cáncer (CIC-IBMCC), Salamanca Dr. Javier Maldonado, Gerente del Hospital Universitario Ramón y Cajal, Madrid Dr. Alfredo Carrato, Hospital Universitario Ramón y Cajal, Madrid 15:00_16:00 Opening conference: Signatures of mutational processes in human cancer Dr. Ludmil Alexandrov, Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, UK 16:00_16:30 RTICC National Coordinator conference: rticc 2013 update Dr. Eugenio Santos, Coordinador Nacional de la RTICC, Centro de Investigación del Cáncer-Instituto de Biología Molecular y Celular del Cáncer (CIC-IBMCC), Salamanca 16:30_16:45 Awards: RTICC Prize for Cooperative Research in Oncology :45_17:15 Awarded project presentation: rticc Prize for Cooperative Research in Oncology :15_17:45 Coffee break and poster viewing

6 14 th ASEICA INTERNATIONAL CONGRESS MONDAY 23 rd SEPTEMBER :45_18:05 Epidemiology and cancer prevention program: Priorities for research in cancer epidemiology and prevention: the RTICC perspective Dr. Josep Maria Borràs, Institut Català d Oncologia (ICO)-IDIBELL, Barcelona 18:05_18:25 Hematological tumors program: When to transplant acute myeloid leukemia patients based on genetic features of the disease: registries and networks experiences Dr. Jordi Sierra, Hospital de la Santa Creu i Sant Pau, Barcelona 18:25_18:45 Breast cancer program: Breast cancer translational research Dr. Joaquín Arribas, Institut d Oncologia Vall d Hebron (VHIO), Barcelona 18:45_19:05 Colorectal and digestive tract tumors program: Colorectal Cancer Translational Research Dr. Gabriel Capellà, Institut Català d Oncología (ICO)-IDIBELL, Barcelona 19:05_19:25 Lung and respiratory tract tumors program: rticc lung and upper respiratory tract cancer program: summary of OBjectives and update of achievements Dr. Luis Montuenga, Centro para la Investigación Médica Aplicada (CIMA), Pamplona

7 MONDAY 23 rd SEPTEMBER :25_19:45 Other solid and pediatric tumors program: Potential and actual synergies in the field of pediatric, gynecological and neural system cancer research Dr. Enrique de Álava, Centro de Investigación del Cáncer-Instituto de Biología Molecular y Celular del Cáncer (CIC-IBMCC), Salamanca 19:45_20:05 Molecular mechanisms: molecular tumor characterization, cancer genomics and biomarkers program: Molecular mechanisms program: update activities 2013 Dr. Eugenio Santos and Dr. Xosé R. Bustelo, Centro de Investigación del Cáncer-Instituto de Biología Molecular y Celular del Cáncer (CIC-IBMCC), Salamanca 20:05_20:15 Closing ceremony RTICC annual meeting VI RTICC ANNUAL MEETING 2013

8 14 th ASEICA INTERNATIONAL CONGRESS TUESDAY 24 th SEPTEMBER :30_10:30 Symposium II: Wide genome analysis of human cancers Chairpersons Dr. Montse Sánchez-Céspedes and Dr. Javier Benítez Genomic landscapes of the 10 breast cancer subtypes Dr. Carlos Caldas, Cambridge Cancer Center, Cambridge, UK Exome sequencing: from research to clinical application Dr. Javier Benítez, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid Selected oral communications *see annex 10:30_11:00 Coffee break and poster viewing 11:00_13:00 Symposium III: Epigenetics and microenvironment Chairpersons Dr. Luis Paz-Ares and Dr. Manel Esteller Myc inhibition as a therapeutic strategy in cancer Dr. Laura Soucek, Fundació VHIO, Barcelona Human cancer epigenetics: from knowledge to application Dr. Manel Esteller, IDIBELL- Hospital Duran y Reynals, Barcelona Selected oral communications *see annex Symposium IV: Deregulation of cell metabolism in cancer development Chairpersons Dr. Ana Osorio and Dr. Manuel Serrano Exploiting cellular metabolism for cancer detection and treatment Dr. Arkaitz Carracedo, CIC biogune, Bizkaia SIRT1 and PI3K in cancer and metabolism Dr. Manuel Serrano, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid Selected oral communications *see annex

9 TUESDAY 24 th SEPTEMBER :00_14:00 Lunch and poster viewing 14:00_15:00 Lecture ii Chairperson Dr. Carlos Caldas Cancer research in the genomic era: from genes to genomes Dr. Carlos López Otín, Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Oviedo 15:00_17:00 Symposium V: Cancer progression and metastasis Chairpersons Dr. Félix Bonilla and Dr. Amparo Cano EMT reversibility in development and cancer Dr. Ángela Nieto, CISC- Universidad Miguel Hernández, Alicante Regulation of cell plasticity and metastasis by lysyl oxidase-like 2 Dr. Amparo Cano, Instituto Investigaciones Biomédicas (CSIC-UAM), Madrid Selected oral communications *see annex Symposium VI: Stem cells and cancer Chairpersons Dr. José Antonio Rodríguez and Dr. Isidro Sánchez Role of polycomb in gene transcription, development and cancer Dr. Luciano Di Croce, Institut Català de Recerca i Estudis Avançats (ICREA), Barcelona Stem cell reprogramming as a driver of cancer: implications in its development and treatment Dr. Isidro Sánchez, Instituto de Biología Molecular y Celular del Cáncer (IBMC), Salamanca Selected oral communications *see annex 17:00_17:30 Coffee break and poster viewing

10 14 th ASEICA INTERNATIONAL CONGRESS TUESDAY 24 th SEPTEMBER :30_19:30 Symposium VII: DNA damage and cancer development Chairpersons Dr. Pedro Lazo-Zbikowski and Dr. Andrés Aguilera Targeting oncogene-induced DNA damage for cancer therapy Dr. Óskar Fernández-Capetillo, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid A new role for tumor suppressors in the removal of R-loops responsible for genome instability Dr. Andrés Aguilera, Universidad de Sevilla- CABIMER, Sevilla Selected oral communications *see annex

11 WEDNESDAY 25 th SEPTEMBER :00_11:00 Symposium VIII: Noncoding RNAs and cancer Chairpersons Dr. Trinidad Caldés and Dr. Miguel Ángel Piris MicroRNAs in lymphoid malignancies. New tools for a better understanding, diagnosis and treatment Dr. Miguel Ángel Piris, IFIMAV, Hospital Marqués de Valdecilla, Santander MicroRNAs as oncogenes and tumor suppressors in cancer development Dr. Pedro Medina, Center for Genomics and Oncology Research, University of Granada, Granada Selected oral communications *see annex Symposium IX: Hypoxia and angiogenesis Chairpersons Dr. Gabriel Capellà and Dr. Luis del Peso The oxygen sensing HIF pathways and cancer cell proliferation Dr. Julián Aragonés, Hospital Universitario de La Princesa, Madrid HIF and PHDs-mediated hypoxia tolerance Dr. Edurne Berra, CIC biogune, Bizkaia Regulation of angiogenesis by Notch and its relevance in cancer Dr. Rui Benedito, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid Regulation of gene expression by hypoxia Dr. Luis del Peso, Instituto Investigaciones Biomédicas (CSIC-UAM), Madrid Selected oral communications *see annex 11:00_11:30 Coffee break and poster viewing

12 14 th ASEICA INTERNATIONAL CONGRESS WEDNESDAY 25 th SEPTEMBER :30_13:00 Presidential Symposium Chairpersons Dr. Alfredo Carrato and Dr. Montse Sánchez-Céspedes ASEICA Awards: Best recent publications by young scientists 13:00_14:00 Lunch and poster viewing 14:00_14:30 ASEICA Assembly *see annex

13 ANNEX SELECTED ORAL COMMUNICATIONS SymPOSium I: novel cancer targets and therapeutic approaches discovery Serum scd26 FOR COLOreCtal CanCer SCreening in family-risk POPulatiON Olalla Otero Estévez, Dpto. de Bioquímica, Genética e Inmunología, Universidad de Vigo, Vigo SPRY1 IS A new target OF the EWS/fli1 ONCOPROtein in EWing SarCOma CellS Florencia Cidre Aranaz, Instutito de Salud Carlos III - Instituto de Investigación en Enfermedades Raras, Madrid DARATUMUMAB, A NOVEL HUMAN CD38 MONOCLONAL ANTIBODY FOR THE treatment OF B-CELL NON HODGKIN LYMPHOMA Anna Vidal Crespo, Department of Hemato-Oncology, IDIBAPS, Barcelona KINESIN FAMILY MEMBER 3B AS A NOVEL MEDIATOR IN PANCREAS CANCER Miren Edurne Ramos, Pathology Dpt., Hospital Universitario Ramón y Cajal, IRYCIS, Madrid Symposium II: Wide genome analysis of human cancers myomirs (mir-1/133a mir-206/133b) AND MET ONCOGENE, SHOWS CO-DEREGULATION IN VESTIBULAR SCHWANNOMA Miguel Torres Martín, Neuro-Oncogenetics Laboratory, Research Unit, Hospital Universitario La Paz, IdiPAZ, Madrid TRANSGENIC MICE BEARING ACTIVE MUTAGENIC TRANSPOSONS FOR THE DETERMINATION OF BREAST CANCER GENES Ángel Ramírez, Molecular Oncology Unit, Centro de Investigaciones Energéticas, Tecnológicas y Medioambientales (CIEMAT), Madrid CIS-REGULATORY GENE EXPRESSION SNPs AND METHYLATION QUANTITATIVE TRAIT LOCI IN COLORECTAL CANCER Laia Paré Brunet, Unit of Biomarkers and Susceptibility, Cancer Prevention and Control Program, IDIBELL Institut Català d Oncologia (ICO) and CIBERESP, Barcelona GENETIC AND PHENOTYPIC CHARACTERIZATION OF FAMILIES WITH FAMILIAL PANCREARIC CANCER AND SCREENING OF HIGH-RISK INDIVIDUALS Carmen Guillén Ponce, Familial Cancer Unit, Medical Oncolgy Department, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid

14 14 th ASEICA INTERNATIONAL CONGRESS ANNEX SELECTED ORAL COMMUNICATIONS Symposium III: Epigenetics and microenvironment THE CHROMATIN REMODELER CHD8 IS REQUIRED FOR TRANSCRIPTION ACTIVATION OF S-PHASE GENES Alicia Subtil Rodríguez, Molecular Biology Department, Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Consejo Superior de Investigaciones Científicas (CSIC), Sevilla DIFFERENTIAL EFFECTS OF ROMIDEPSIN, A HISTONE DEACETYLASE INHIBITOR, IN B-CELL LYMPHOMAS AND BCL6 GENE REGULATION María G. Cortiguera, Dpto. Biología Molecular-IBBTEC, Universidad de Cantabria, Santander MECHANISM OF DE NOVO RESISTANCE TO 5FU AND OXALIPLATIN INDUCED BY CARCINOMA-ASSOCIATED FIBROBLASTS IN COLORECTAL CANCER Samuel Gonçalves Ribeiro, IDIBELL, Barcelona MECHANISMS OF SMARCA4 INACTIVATION IN LUNG CARCINOGÉNESIS Paola Peinado Fernández, Universidad de Granada y Centro GenyO de Investigación Oncológica, Granada SymPOSium iv: Deregulation of cell metabolism in cancer development FUNCIONAL AND GENOMIC ANALYSIS IDENTIFY THE LACTATE TRANSPORTER MCT4 AS A POTENTIAL METABOLIC TARGET IN RENAL CELL CARCINOMA Claudio Santos, Translational Cancer Therapeutics Laboratory, Cancer Research UK, London Research Institute, London, UK ALTERATIONS IN AMINOACID METABOLISM IN PROSTATE CANCER Amaia Arruabarrena Aristorena, CIC biogune, Bizkaia SOMATIC VHL GENE ALTERATION IN HEREDITARY AND SPORADIC HEAD AND NECK PARAGANGLIOMAS: IDENTIFICATION OF A NOVEL TARGET Ana Merlo, Hospital Universitario Central de Asturias and Instituto Universitario de Oncología del Principado de Asturias, Oviedo Symposium V: Cancer progression and metastasis ROLE OF SON OF SEVENLESS PROTEINs, SOS1 AND SOS2, IN MICE SKIN TUMOR INITIA- TION AND DEVELOPMENT Pilar Liceras-Boillos, Instituto de Biología Molecular y Celular del Cáncer (USAL-CSIC), Salamanca

15 ANNEX SELECTED ORAL COMMUNICATIONS DIOXIN RECEPTOR DIFFERENTIALLY ACTS ON THE TUMOR CELL AND THE MICROENVIRONMENT TO SUPPRESS MELANOMA GROWTH AND METASTASIS María Contador, Dpto. de Bioquímica y Biología Molecular, Universidad de Extremadura, Cáceres THE NUCLEAR COREPRESSOR NCoR IS AN ESSENTIAL MEDIATOR OF THE ANTI-TUMORIGENIC AND ANTI-METASTATIC ACTIONS OF THE THYROID HORMONE RECEPTOR β Olaia Martínez-Iglesias, Instituto de Investigaciones Biomédicas, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Madrid REGULATION OF PROTEIN TRANSLATION AND c-jun EXPRESSION BY PROSTATE TUMOR OVEREXPRESED 1 (PTOV1) Verónica Cánovas, Research Unit in Biomedicine, Translational and Pediatrics Oncology, Institut de Recerca Vall d Hebron and Universitat Autònoma, Barcelona Symposium VI: Stem cells and cancer ROle OF the midkine / anaplasic LYMPHOma kinase axis in glioma Stem CellS David Dávila, Department of Biochemistry and Molecular Biology I, School of Biology, Universidad Complutense, Madrid OSTEOSARCOMA generation FROM C-FOS EXPRESSING HUMAN MESENCHYMAL STEM Ander Abarrategui, Instiuto de Salud Carlos III, Madrid EXPreSSION OF fus-chop fusion PROtein in immortalized/transformed human mesenchymal Stem CellS DriveS mixoid liposarcoma FOrmatiON René Rodríguez, Hospital Universitario Central de Asturias and Instituto Universitario de Oncología del Principado de Asturias, Oviedo A NOVEL MOLECULAR MECHANISM INVOLVED IN CANCER DEVELOPMENT REVEALED BY TARGETING MAFB TO HEMATOPOIETIC PROGENITORS Carolina Vicente Dueñas, Experimental Therapeutics and Translational Oncology Program, Instituto de Biología Molecular y Celular del Cáncer (CSIC), Universidad de Salamanca, Institute of Biomedical Research of Salamanca (IBSAL), Salamanca

16 14 th ASEICA INTERNATIONAL CONGRESS ANNEX SELECTED ORAL COMMUNICATIONS Symposium VII: DNA damage and cancer development EXPLORING THE ROLE OF EWSR1 IN REPLICATION STRESS Isabel Morgado Palacín, Genomic Instability Group, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid REGULATION OF the COMPlexeS involved in Dna-Damage response BY vrk1 Marcella Salzano, Instituto de Biología Molecular y Celular del Cáncer (IBMCC), Consejo Superior de Investigaciones Científicas-Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca A LOCALIZED DDR IS ACTIVATED AT THE MIDBODY TO RESOLVE DNA BRIDGES María Nieto Soler, Genomic Instability Group, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid CELL CYCLE-DEPENDENT PHOSPHORYLATION AND DEGRADATION OF KSR1 José Lozano, Universidad de Málaga, Málaga A CONDITIONAL KNOCK-IN MOUSE MODEL REVEALS ESSENTIAL ROLES OF BRCA1 UBIQUITIN LIGASE ACTIVITY Andrés López Contreras, Genomic Instability Group, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid ALTERATIONS OF A MITOSIS -DIFFERENTIATION CHECKPOINT AND GENOMIC INSTABILITY IN SKIN CARCINOMA CELLS Pilar Alonso Lescure, Cell Cycle, Stem Cell fate and Cancer Lab, FMDV-IFIMAV, Santander ROLE OF HUMAN POLD3 IN GENOME INTEGRITY Emanuela Tumini, Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Sevilla Symposium VIII: Noncoding RNAs and cancer CYTOSINE-5 METHYLATION IN TRNA PROTECTS SKIN FROM UV AND OXIDATIVE STRESS DAMAGE Sandra Blanco, Wellcome Trust Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK MULTIPLEXED NGS FOR mirna PROFILING IN RESECTABLE NON SMALL CELL LUNG CANCER Sandra Gallach, Laboratorio Oncología Molecular, Fundación para la Investigación del Hospital General Universitario de Valencia, Valencia

17 ANNEX SELECTED ORAL COMMUNICATIONS GENOME-WIDE mirna EXPRESSION ANALYSIS OF THYROID CANCER BY NGS IDENTIFIES mir-146b-3p AS A KEY REGULATOR OF THYROID DIFFERENTIATION Garcilaso Riesco Eizaguirre, Instituto de Investigaciones Biomédicas CSIC-UAM / IdiPAZ / Hospital Universitario de Móstoles, Madrid PERIPHERAL BLOOD MICRORNAS EXPRESSION PROFILE: A FINGERPRINT FOR metastatic PROSTATE CANCER V. Medina Villaamil, INIBIC, Oncology Area, Centro Hospitalario Universitario (CHUAC), A Coruña Symposium IX: Hypoxia and angiogenesis SERRATED COLORECTAL ADENOCARCINOMA SHOWS A DIFFERENT PROFILE OF ANGIOGENIC MARKERS COMPARED TO CONVENTIONAL CARCINOMA María del Carmen Turpín Sevilla, Universidad Francisco de Vitoria, Madrid CONTRASTING RESPONSES OF NON-SMALL CELL LUNG CANCER TO ANTIANGIOGENIC THERAPIES DEPENDING ON HISTOLOGY Jackeline Agorreta, Division of Oncology, Centro de Investigación Médica Aplicada, Universidad de Navarra, Pamplona SOX9 FUNCTION IN CANCER A. Matheu, Neurooncology group, Biodonostia Instituto de Investigación, San Sebastián ASEICA AWARDS: BEST RECENT PUBLICATIONS BY YOUNG SCIENTISTS Presidential Symposium: Awards: AN EXTRA ALLELE OF CHK1 LIMITS ONCOGENE-INDUCED REPLICATIVE STRESS AND PROMOTES TRANSFORMATION Andrés López Contreras, Genomic Instability Group, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid DEPENDENCY OF COLORECTAL CANCER ON A TGF-BETA-DRIVE PROGRAM IN STROMAL CELLS FOR METASTASIS INITIATION Elisa María Espinet Hernández, Oncology Programme, Institut de Recerca Biomèdica (IRB), Barcelona

18 14 th ASEICA INTERNATIONAL CONGRESS ANNEX SELECTED ORAL COMMUNICATIONS Accesits: GERMINAL CENTRE PROTEIN HGAL PROMOTES LYMPHOID HYPERPLASIA AND AMYLOIDOSIS VIA BCR-MEDIATED SYK ACTIVATION Isabel Romero Camarero, Experimental Therapeutics and Translational Oncology Program, Instituto de Biología Molecular y Celular del Cáncer (CSIC), Universidad de Salamanca, Institute of Biomedical Research of Salamanca (IBSAL), Salamanca EPIGENETIC DISRUPTION OF CADHERIN-11 IN HUMAN CANCER METASTASIS Francisco Javier Carmona Sanz, Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona AMPK ACTIVATION BY ONCOGENESIS IS REQUIRED TO MAINTAIN CANCER CELL PROLIFERATION IN ASTROCYTIC TUMORS Marcos Ríos García, Departamento de Fisioloxía, CIMUS, Facultad de Medicina, Santiago de Compostela INHIBITION OF DYRK1A DESTABILIZES EGFR AND REDUCES EGFR-DEPENDENT GLIOBLASTOMA GROWTH Cristina Zahonero Casans, Neuro-oncology Unit, Instituto de Salud Carlos III- UFIEC, Madrid

19 HOSPITAL UNIVERSITARIO RAMÓN Y CAJAL LOCATION MAP 3 1 Salón de Actos Train RENFE 2 3 Aula Docencia - 1 st floor (Pabellón Docente) Coffee Break and posters Bus L Metro Lunch P Parking

20 14 th ASEICA INTERNATIONAL CONGRESS Gold Silver Hospital Universitario Ramón y Cajal Ctra. de Colmenar Viejo km 9, 100 Madrid T Bronze The Home for Gene Technology Under the auspices of Accreditation requested to the Spanish System of Continuing Medical Education Technical Secretariat TACTICS MD T [email protected]