Curriculum Vitae Harvard Medical School/ Harvard School of Dental Medicine

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1 Curriculum Vitae Harvard Medical School/ Harvard School of Dental Medicine Date Prepared: November 16, 2009 Name: Zafira Castaño Corsino, Ph.D. Work Phone: (34) Work Place of Birth: Asturias, Spain Education 2002 BSc Biochemistry, Navarra, Spain 2004 Master s Degree Biochemistry 2006 Ph.D. (Summa Cum Lauden) Postdoctoral Training Research Studentship Fellowship Research and Teaching Fellowship Biochemistry Advisor: Rubén Pío Ph.D. Spanish Ministry of Science and Technology Fellowship Foundation for Applied Medical Research, Navarra, Spain Applied Medical Research Centre, University of Navarra. Applied Medical Research Centre, University of Navarra Postdoctoral Research position Cell Biology and Stem Cells Advisor: Robert Kypta, Ph.D. Cooperative Centre for Research in Biosciences, Vizcaya, Spain Faculty Academic Appointments 09/02-05/06 Assistant Professor Biochemistry Other Professional Positions 2000 Student Volunteer, Department of Animal Production Student Volunteer, Department of Histology and Pathology Regional Animal Research Centre of Asturias, Asturias, Spain 1

2 2001 Student Volunteer, Department of Hematology 2008 Research Collaborator, Department of Developmental Neurobiology Hospital of Asturias, Asturias, Spain Medical Research Council, King s College of London, London, United Kingdom Committee Service Local Young Neuroscientific Committee Spanish Society of Neuroscience XIII Spanish Society of Neuroscience Comitte Member Professional Societies Spanish Society of Biochemistry and Molecular Biology Associate Member Spanish Society of Neuroscience Associate Member 2009 Young Neuroscientific Club (Spanish Society of Neuroscience) 2009 Founder Honors and Prizes 2005 Travel Award Spanish Ministry of Science and Technology Travel award to attend to the workshop Acto Severo Ochoa 2007 British Council Research Exchange Program Award RXP387 British Council Exchange program to compliment my postdoctoral studies, translating my previous results in vitro into an in vivo model supported by Phillip Gordon-Weeks laboratory. 2

3 Report of Funded and Unfunded Projects Funding Information Past New members of hnrnp family proteins: Evaluation of their potential as tumor suppressor genes markers in the lung cancer early detection Spanish Ministry of Health (FIS), PIO21116 Our main goal was to study the role of the putative tumor suppressor gene PCBP4 in lung cancer Obtention and initial characterization of a knockout mice for the tumor suppressor gene PCBP4 Navarra Local Council, Science Department Our main goal was to obtain a conditional alphacp-4 KO mice Study the Wnt role in prostate cancer Spanish Ministry of Science and Tecnology. National Plan of Research Proyects I+D+I. SAF Our main goal was to study the role of GSK3 in SH-SY5Y and NTera-2 cell lines. Current Study the role and regulation of GSK3 in proliferation and cell death Spanish Ministry of Science and Tecnology. National Plan of Research Proyects I+D+I. SAF Our main goal is being to develop GSK-3 inhibitors that avoid GSK-3 neuronal toxicity. Report of Local Teaching and Training Teaching of Students in Courses Biochemistry 2 nd year Pharmacy students Biochemistry 2nd year Chemistry students Biochemistry and Molecular Biology I Biochemistry and Molecular Biology II Biochemistry and Molecular Biology Clinical Biochemistry and Molecular Pathology 4 and 5 th year Biology students 3 92 hours 20 hours 54 hours 48 hours 100 hours 40 hours

4 Biochemistry and Molecular Biology II Biochemistry and Molecular Biology I, 40 hours 60 hours Report of Scholarship Publications 1 Ajona D., Castano Z., Garayoa M., Zudaire E., Pajares MJ., Martinez A., Cuttitta F., Montuenga LM., Pio R. Expresión of Complement Factor H by Lung Cancer Cells: Effects on the Activation of the Alternative Pathway of Complement. Cancer Research. 2004; 64, Pio R, Zudaire I, Pino I, Castaño Z, Zabalegui N, Vicent S, Garcia-Amigot F, Odero MD, Toledo G, Garcia-Foncillas J, Calasanz MJ, Montuenga LM. αcp-4, a putative tumor suppressor gene at 3p21, but not its alternative splice variant alphacp-4a, is underexpressed in lung cancer. Cancer Research. 2004; 64, Castaño Z., Kypta R.M. Houskeeping proteins: limitations as references during neuronal differentiation. The Open Neuroscience Journal. 2008; 2: Castaño Z., Vergara-Irigaray N, Pajares MJ, Montuenga LM., Pio R. Expression of αcp-4 inhibits cell cycle progression and suppresses tumorigenicity in lung cancer cells in vitro and in vivo. Int J Cancer. 2008;122(7): Castaño Z., Phillip R. Gordon-Weeks, Kypta R.M. The brain-specific isoform of GSK3b is necessary and sufficient for axon elongation. Under review in J. Neurochemistry. Thesis Title of thesis: Role of PCBP4 in lung cancer. Evaluation of its role as a tumor suppressor gene. Advisor of thesis: Rubén Pío Osés Ph.D. Abstracts, Poster Presentations and Exhibits Presented at Professional Meetings 1 11th World Conference on Lung Cancer-International Association for the Study of Lung Cancer (IASLC.) Z. Castaño, L.M. Montuenga, R. Pio. Role of the putative tumor suppressor alphacp-4 and its alternatively spliced variant alphacp-4a in lung cancer growth. Barcelona, Spain, Poster discussion. 2 ASEICA Meeting. Z. Castaño, N. Vergara, L.M. Montuenga, R. Pio. alphacp-4, un posible gen supresor de tumores en cáncer de pulmón, inhibe el crecimiento de células tumorales tanto in vitro como in vivo. Pamplona, Spain, Oral ation. 4

5 3 International Conference Wnt Signaling in Development and Disease. C.Elizalde, N. Elguezabal, Z. Castano, R. Jiménez, R. Kypta. Characterisation of Wnt signalling components in human embryonal carcinoma cells. Berlin-Buch, Germany, Poster. 4 XIII Congress from Spanish Society of Neuroscience. Zafira Castaño, Phillip R. Gordon-Weeks and Robert M. Kypta. Distinct roles for GSK-3 isoform in neurite outgrowth. Tarragona, 17 th September Oral ation. 5