Training Assistant Lecturer

Transcription

1 Curriculum vitae PERSONAL INFORMATION Constanca Pomba WORK EXPERIENCE January 2010 Present Associate Professor Internal Medicine and Research activities in Antimicrobial and Biocide Resistance and Vaccine development and Bacterial Pathogenesis May 2002 December 2009 Assistant Professor Internal Medicine and Research activities in Antimicrobial and Biocide Resistance and Bacterial Pathogenesis July 1994 April 2002 Assistant Lecturer Internal Medicine and Research activities in Antimicrobial and Biocide Resistance and Bacterial Pathogenesis October 1993 June 1994 Training Assistant Lecturer Internal Medicine October 1989 September 1993 Research fellow Parasitology ( ) Animal Virology and Imunology ( ) EDUCATION AND TRAINING October 1985 March 1991 Médico-Veterinário Veterinarian January 1992 July 1994 Master of Science MSc Tropical Veterinary Medicine October 1998 April 2002 Doctor of Philosophy PhD Veterinary Sciences 28/7/15 European Union, Page 1 / 5

2 ADDITIONAL INFORMATION Expertise Antimicrobial resistance. Molecular basis of antimicrobial resistance in Gram negative and Gram-positive bacteria. Methodology, breakpoints, MIC, cut-off values, reporting of resistance. Clonal dispersal of drug-resistant bacterial pathogens. Surveillance of antimicrobial resistance in Veterinary Medicine and molecular epidemiology of antimicrobial resistance genes in bacteria of animal origin and Public Health repercussions. Antimicrobial chemotherapy Efficacy of antimicrobials and use of antimicrobials in different target animal species (especially dogs and cats). Antimicrobial chemotherapy of multidrug-resistant bacteria. Bacterial Pathogenesis and Vaccine development. Publications Pleuromutilins: use in food-producing animals in the European Union, development of resistance and impact on human and animal health. van Duijkeren E, Greko C, Pringle M, Baptiste KE, Catry B, Jukes H, Moreno MA, Pomba MC, Pyörälä S, Rantala M, Ružauskas M, Sanders P, Teale C, Threlfall EJ, Torren-Edo J, Törneke K. J Antimicrob Chemother Aug;69(8): Macrolides and lincosamides in cattle and pigs: use and development of antimicrobial resistance. Pyörälä S, Baptiste KE, Catry B, van Duijkeren E, Greko C, Moreno MA, Pomba MC, Rantala M, Ružauskas M, Sanders P, Threlfall EJ, Torren-Edo J, Törneke K. Vet J May;200(2): Oliveira M, Dias FR, Pomba C. Biofilm and fluoroquinolone resistance of canine Escherichia coli uropathogenic isolates. BMC Res Notes Aug 7;7:499. Belas A, Salazar AS, Gama LT, Couto N, Pomba C. Risk factors for faecal colonisation with Escherichia coli producing extended-spectrum and plasmid-mediated AmpC β-lactamases in dogs. Vet Rec Aug 30;175(8):202. Pomba C, Endimiani A, Rossano A, Saial D, Couto N, Perreten V. First report of OXA-23-mediated carbapenem resistance in sequence type 2 multidrug-resistant Acinetobacter baumannii associated with urinary tract infection in a cat. Antimicrob Agents Chemother. 2014;58(2): Within-lineage variability of ST131 Escherichia coli isolates from humans and companion animals in the south of Europe. Pomba C, López-Cerero L, Bellido M, Serrano L, Belas A, Couto N, Cavaco- Silva P, Rodríguez-Baño J, Pascual A. J Antimicrob Chemother Jan;69(1): Virulence genotypes of Escherichia coli canine isolates from pyometra, cystitis and fecal origin. Mateus L, Henriques S, Merino C, Pomba C, Lopes da Costa L, Silva E. Vet Microbiol Oct 25;166(3-4): Biocide and antimicrobial susceptibility of methicillin-resistant staphylococcal isolates from horses. Couto N, Belas A, Tilley P, Couto I, Gama LT, Kadlec K, Schwarz S, Pomba C. Vet Microbiol Sep 27;166(1-2): doi: /j.vetmic Epub 2013 Jun 10. Genetic Relatedness, Antimicrobial and Biocide Susceptibility Comparative Analysis of Methicillin- Resistant and -Susceptible Staphylococcus pseudintermedius from Portugal. Couto N, Belas A, Couto I, Perreten V, Pomba C. Microb Drug Resist Jul 2. [Epub ahead of print] First report of swine-associated methicillin-resistant Staphylococcus aureus ST398 in Lithuania. Ruzauskas M, Couto N, Belas A, Klimiene I, Siugzdiniene R, Pomba C. Pol J Vet Sci. 2013;16(1): M. D. Pinho, S. C. Matos, C. Pomba, A. Lübke-Becker, L. H. Wieler, S. Preziuso, J. Melo-Cristino, M. Ramirez. (2013). "Multilocus Sequence Analysis of Streptococcus canis Confirms the Zoonotic Origin of Human Infections and Reveals Genetic Exchange with Streptococcus dysgalactiae subsp. equisimilis" Journal of Clinical Microbiology ;51(4): T.M. Braga, C. Pomba, M. F. Silva Lopes (2013). High-level vancomycin resistant Enterococcus faecium related to humans and pigs found in dust from pig breeding facilities. Vet Microbiol., 161 (3-4): N. Couto, P. Tilley, J. Simões, J.P. Sales Luis, C. Pomba. (2012). First Report of Methicillin-Resistant Staphylococcus aureus ST5 and ST398 from Purebred Lusitano Horses Journal of Equine Veterinary Science, Vol. 32, Nº5, pp L. Fernandes, M. Centeno, A. Belas, T. Nunes, P. Lopes Alves, N. Couto, C. Pomba. (2012). Immediate after birth transmission of epidemic Salmonella enterica Typhimurium monophasic strains 28/7/15 European Union, Page 2 / 5

3 in pigs is a likely event Journal of Antimicrobial Chemotherapy, Vol. 67, Nº12, pp K. Kadlec, A.T. Feßler, N. Couto, C.F. Pomba, S. Schwarz. (2012). Unusual small plasmids carrying the novel resistance genes dfrk or apma isolated from methicillin-resistant or -susceptible staphylococci Journal of Antimicrobial Chemotherapy, Oxford Journals, Vol. 67, Nº10, pp L.B. Price, M. Stegger, H. Hasman, M. Aziz, J. Larsen, P.S. Andersen, T. Pearson, A.E. Waters, J.T. Foster, J. Schupp, J. Gillece, E. Driebe, C.M. Liu, B. Springer, I. Zdovc, A. Battisti, A. Franco, J. Zmudzki, S. Schwarz, P. Butaye, E. Jouy, C. Pomba, M.C. Porrero, R. Ruimy, T.C. Smith, D.A. Robinson, J.S. Weese, C.S. Arriola, F. Yu, F. Laurent, P. Keim, R. Skov, F.M. Aarestrup. (2012). Staphylococcus aureus CC398: host adaptation and emergence of methicillin resistance in livestock. MBio, American Society of Microbiology, Vol. 3, Nº 1, e E. Van Duijkeren, B. Catry, C. Greko, M. A. Moreno, M. C. Pomba, S. Pyörälä, M. Ruzaukas, P. Sanders, E. J. Threlfall, J. Torren-Edo e K. Törneke [SCIENTIFIC ADVISORY GROUP ON ANTIMICROBIALS (SAGAM)]- (2011) Review on methicillin-resistant Staphylococcus pseudintermedius. Journal of Antimicrobial Chemotherapy, 66 (12): Marques C., Ferreira M., Gomes J., Leitão N., Costa M., Serra P., Duarte Correia J. H., Pomba C. (2011). Blood type A, B and AB frequencies in 515 domestic shorthair cats from Lisbon area. Veterinary Clinical Pathology. 40, Cavaco L. M., Hasman H., Aarestrup F. M., MRSA collaborating group (MRSA-CG) (Members of MRSA-CG: Jaap A Wagenaar, Haitske Graveland, Kees Veldman, Dik Mevius, Alexandra Fetsch, Bernd-Alois Tenhagen, M. Concepcion Porrero, Lucas Dominguez, Sophie A Granier, Eric Jouy, Patrick Butaye, Eva Kaszanyitzky, Adam Dán, Jacek Zmudzki, Antonio Battisti, Alessia Franco, Stefan Schwarz, Montserrat Gutierrez, J Scott Weese, Shengui Cui, Constança Pomba) (2011). Zinc resistance of Staphylococcus aureus of animal origin is strongly associated with methicillin resistance. Veterinary Microbiology. Accepted for publication 14 February. Couto N., Pomba C., Moodley A., Guardabassi, L. (2011). Prevalence of methicillin-resistant staphylococci among dogs and cats attending a veterinary teaching hospital in Portugal. Veterinary Record. Accepted for publication. T. M. Braga, P. E. Marujo, C. Pomba e M. F. Silva Lopes (2011) Involvement, and dissemination, of the enterococcal small multidrug resistance transporter QacZ in resistance to quaternary ammonium compounds. Journal of Antimicrobial Chemotherapy, 66: Kadlec K., Pomba C. F., Couto N., Schwarz S. (2010). Small plasmids carrying vga(a) or vga(c) genes mediate resistance to lincosamides, pleuromutilins and streptogramin A antibiotics in methicillinresistant Staphylococcus aureus ST398 from swine. Journal of Antimicrobial Chemotherapy. 65: Pomba C., Baptista F. M., Couto N., Loução F., Hasman H. (2010). Methicillin-resistant Staphylococcus aureus CC398 isolates with indistinguishable ApaI restriction patterns in colonized and infected pigs and humans. Journal of Antimicrobial Chemotherapy, 65, Baptista F. M., Alban L., Nielsen L. R., Domingos I., Pomba C., Almeida V. (2010). Use of Herd Information for Predicting Salmonella Status in Pig Herds. Zoonoses and Public Health, 57 (Suppl. 1), 57 (Suppl. 1), Pomba C. Couto N., and Moodley A. (2010). Treatment of a lower urinary tract infection in a cat caused by a multidrug-methicillin-resistant Staphylococcus pseudintermedius and Enterococcus faecalis. J Feline Medicine and Surgery. 12, Catry B., Van Duijkeren E., Pomba M.C., Greko C., Moreno M. A., Pyorala S., Ruzauskas M., Sanders P., Threlfall E. J., Ungemach F., Torneke K., Munoz-Madero C. and Torren-Edo J. - Scientific Advisory Group on Antimicrobials (SAGAM) (EMA) (2010). Reflection paper on MRSA in foodproducing and companion animals: epidemiology and control options for human and animal health. Epidemiol. Infect., 138, Pyürälä S., Greko C., and Matias Ferreira Pomba M. C. (2009). Use of glycopeptides in veterinary medicine.the Veterinary Record, 543. Greko C., Badiola J. I., Catry B., van Duijkeren E., Moreno M. A., Matias Ferreira Pomba M. C., Pyürälä S., Ruzauskas M., Sanders P., Threlfall E. J., Ungemach F., Törneke K. and Torren-Edo, J. - Scientific Advisory Group on Antimicrobials of the Committee for Medicinal Products for Veterinary Use, European Medicines Agency (EMEA)(2009). Reflection paper on the use of third and fourth generation cephalosporins in food producing animals in the European Union: development of resistance and impact on human and animal health. Journal of Veterinary Pharmacology and Therapeutics. 32, Silva E., Leitão S., Tenreiro T., Pomba C., Nunes T., Lopes da Costa L., Mateus L. (2009). Genomic and phenotypic characterization of Escherichia coli isolates recovered from the uterus of puerperal 28/7/15 European Union, Page 3 / 5

4 dairy cows. Journal of Dairy Science 92, Pomba C., Hasman H., Cavaco L. M., Diniz da Fonseca J., and Aarestrup F. M. (2009). First description of MRSA CC30 and CC398 from swine in Portugal. International Journal of Antimicrobial Agents, 34, Pomba C., Fonseca J. D., Baptista B.C., Correia J.D., and Martínez-Martínez,L.(2009). "Detection of the Pandemic O25 ST131 Human Virulent Escherichia coli CTX-M-15-producer Clone Harbouring the qnrb2 and aac(6 )-Ib-cr Genes in a Dog". Antimicrobial Agents and Chemotherapy, 53, Delgado M., Neto, I., Duarte-Correia, J. H. and Pomba, C. (2007). Antimicrobial resistance and evaluation of susceptibility testing among pathogenic enterococci isolated from dogs and cats. International Journal of Antimicrobial Agents, 30, Pomba-Féria, C. and Caniça, M. (2003). A novel sequence framework (blatem-1g) encoding the parental TEM-1 beta-lactamase. FEMS Microbiology Letters, 220 (2), Féria, C., Ferreira, E., Duarte Correia, J., Gonçalves, J. and Caniça, M. (2002). Patterns and mechanisms of resistance to beta-lactams and to beta-lactamase inhibitors in uropathogenic Escherichia coli isolated from dogs in Portugal. Journal of Antimicrobial Chemotherapy, 49 (1), Féria, C., Machado, J., Duarte Correia, J., Gonçalves and Gaastra, W. (2001). Distribution of papg alleles among uropathogenic Escherichia coli isolated from different species. FEMS Microbiology Letters 202 (2), Féria, C., Machado, J., Duarte Correia, J., Gonçalves and Gaastra, W. (2001). Virulence genes and P fimbriae PapA subunit diversity in canine and feline uropathogenic Escherichia coli. Veterinary Microbiology 82 (1), Projects Participation as a coordinator: :PTDC/CVT-EPI/4345/2012, "Immunogenicity of vaccine candidate antigens from Staphylococcus pseudintermedius in Canis canis", Centro de Investigação Interdisciplinar em Sanidade Animal, Fundação para a Ciência e a Tecnologia : PTDC/SAU-SAP/113651/2009, "Use of cephalosporins in pigs - assessing the link between usage, resistance and food safety", Centro de Investigação Interdisciplinar em Sanidade Animal, Fundação para a Ciência e a Tecnologia : Community base-line study, Survey on the prevalence of Methicillin-resistant Staphylococcus aureus in herds of breeding pigs to be carried out in the Member States, 2008/55/EC - Responsible for the Analysis of the MRSA Survey in Portugal as the Coordinator of the Laboratory of Antimicrobial Resistance of the Faculdade de Medicina Veterinária Universidade Técnica de Lisboa : Project CIISA 82/06 Molecular characterization of the resistance mechanisms to fluoroquinolones of clinical Escherichia coli strains of animal origin, Centro de Investigação Interdisciplinar em Sanidade Animal, Fundação para a Ciência e a Tecnologia : Project CIISA 36/99 Bacterial urinary tract infection in dogs: a molecular approach to pathogenesis and antimicrobial resistance, Centro de Investigação Interdisciplinar em Sanidade Animal, Fundação para a Ciência e a Tecnologia. Participation as member of the FMV team in the following research projects: : Project CIISA 83/09 Salmonella on pig herds in Portugal within-herd prevalence, serotype distribution and antimicrobial resistance of isolates, Centro de Investigação Interdisciplinar em Sanidade Animal, Fundação para a Ciência e a Tecnologia : Project POCTI/43033/CVT/2001, Resistance to fluoroquinolones and beta-lactams in enteric Escherichia coli strains isolated from farm animals, Fundação para a Ciência e a Tecnologia : Project POCTI/3482/CVT/99, Staphylococci of animal origin: molecular identification, mechanisms of antimicrobial resistance and virulence, Fundação para a Ciência e a Tecnologia : Project POCTI/36253/CVT/99, Mechanisms of resistance to beta-lactams and quinolones of uropathogenic Escherichia coli strains isolated from animals, Fundação para a Ciência e a Tecnologia : Project PMCT/C/AGR/947/90, Study of the immune cellular mechanisms mediated by cytotoxic T lymphocytes (LCT) in African Swine Fever Infection, Fundação para a Ciência e a Tecnologia. Memberships Desde/Since 2010 European Society of Nephrology and Urology (ESVNU). 28/7/15 European Union, Page 4 / 5

5 Desde 2007 Sociedade Portuguesa de Doenças Infeccciosas e Microbiologia Clínica. Desde 2006 European Society of Veterinary Internal Medicine (ESVIM). Desde 2006 American Society for Microbiology (ASM). Desde 2005 European Society of Clinical Microbiology and Infectious Diseases (ESCMID). Desde 1996 Associação Portuguesa dos Médicos Veterinários Especialistas de Animais de Companhia (APMVEAC). 1ª Secretária da Assembleia Geral desde Dezembro de Desde 1996 Associação Europeia dos Médicos Veterinários Especialistas de Animais de Companhia (FECAVA). Desde 1996 World Small Animal Veterinary Association (WSAVA). Desde 1993 Sociedade Portuguesa de Imunologia. Desde 1992 Ordem Nacional dos Médicos Veterinários. Desde 1990 Sociedade Portuguesa de Patologia Animal. Desde1989 Sociedade Portuguesa de Ciências Veterinárias. Other Relevant Information Expert of the European Agency for Evaluation of Medicinal Products (2003). Member of the Antimicrobial Working Party (AWP)/Scientific Advisory Group on Antimicrobials (SAGAM) of the European Agency for Evaluation of Medicinal Products (2007). Vice-President AWP (2013). Responsible for the Clinical Bacteriology section of the Laboratório de Análises Clínicas of the of the Faculdade de Medicina Veterinária(FMV)-UTL(2000). Chief of the Animal Blood Bank of the Veterinary Teaching Hospital of the FMV-UTL (2008). Member of the Governmental Group for Veterinary Medicine Evaluation of Direcção Geral de Veterinária, Ministério de Agricultura e Pescas (2009). Head of the Laboratory of Antimicrobial and Biocide Resistance of the FMV UTL (2010). Referee for the Journal of Microbiological Methods, "Revista da Sociedade Portuguesa de Ciências Veterinária", Diagnostic Microbiology and Infectious Diseases, "Journal of Antimicrobial Chemotherapy", "Veterinary Microbiology", Plos One, Antimicrobial Agents Chemotherapy, Microbial Drug Resistance, International Agents and Antimicrobial Chemotherapy. Editor of the Journal of Antimicrobial Chemotherapy from the BSAC (2014) 28/7/15 European Union, Page 5 / 5