Multi-Enzyme Supplement for Intensive Digestive Support

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2 Specially formulated for those with complex GI issues. Vital-Zymes Complete is a high-potency, multi-enzyme supplement formulated for individuals with compromised gastrointestinal function who require maximum digestive support. Containing an unusually complete range of plant- and microbial-based enzymes, Vital-Zymes Complete helps maintain normal enzyme levels that support the body s digestive capabilities and assist intestinal repair mechanisms. Vital-Zymes Complete Multi-Enzyme Supplement for Intensive Digestive Support More comprehensive than standard enzyme blends. While basic enzyme supplements typically supply protease, amylase, and lipase for digestion of protein, starch, and fat respectively, these products often lack more specific enzymes needed for optimal digestion of peptides, disaccharides, fiber, and other food components. In contrast, Vital-Zymes Complete contains a unique blend of 20 enzymes that work in tandem to reduce large, complex molecules into their smallest units to facilitate healthy digestion and efficient absorption. Two capsules of Vital-Zymes Complete deliver a broad complement of crucial enzymes that lend maximum support for digestion of a full range of foods as found in a typical meal. Also available: Vital-Zymes Chewable, a convenient choice for those who may prefer a chewable tablet. Vital-Zymes Complete Vital-Zymes Chewable Supplement Facts Supplement Facts Serving Size 2 Capsules Serving Size 2 Chewable Tablets Amount Per 2 Capsules Amount Per 2 Chewable Tablets Comprehensive Enzyme Blend 800 mg* With the following minimum enzyme activity: Carbohydrate Specific Enzymes Amylase 1,830 BAU** Alpha-Amylase 100 DU** Glucoamylase (with isomaltase side chain activity) 30 AGU** Sugar Specific Enzymes 1,500 ALU** Sucrase (invertase) 400 SU** Maltase 200 DP** Pullulanase (debranching enzyme with isomaltase side chain activity) 25 U** Vegetable/Plant Fiber Specific Enzymes Cellulase 500 CU** Hemicellulase/Pectinase/Phytase Complex 200 HSU** Phytase 10 PU** Beta-Glucanase 20 BGI** Alpha-Galactosidase 40 GaIU** Galactomannase 200 HCU** Protein and Peptide Specific Enzymes Acid Protease Alkaline Protease Protease/Peptidase Complex with endopeptidase, exopeptidase, and DPP-IV activity 50 SAPU** 50 PC** 40,000 HUT** Fat Specific Enzyme Lipase 1,500 FIPU** Other Enzymes Lysozyme**** Serratia peptidase (enteric-coated)*** 320 mg* With the following minimum enzyme activity: Carbohydrate Specific Enzymes Lactase Comprehensive Enzyme Blend 100,000 SHU** 2,500 SPU** *Daily Value not established. Other ingredients: Vegetarian capsule (hydroxypropyl methylcellulose, water), vegetable oil powder, and cellulose. **Units are those used in edition five (V) of the Food Chemicals Codex (FCC) ***Peptizyme SP, a registered trademark of Specialty Enzymes ****NOTE: Lysozyme is purified from egg white. Individuals with known egg white allergy should consult their physician prior to use. K-VZM 120 vegetarian capsules Amylase 732 BAU** Alpha-Amylase 40 DU** Glucoamylase (with isomaltase side chain activity) 12 AGU** Sugar Specific Enzymes Lactase 600 ALU** Sucrase (invertase) 54 INVU** Maltase 80 DP** Pullulanase (debranching enzyme with isomaltase side chain activity) 10 PUN** Vegetable/Plant Fiber Specific Enzymes Cellulase 200 CU** Hemicellulase/Pectinase/Phytase Complex 80 HSU** Phytase 4 FTU** Beta-Glucanase 8 BGU** Alpha-Galactosidase 16 GaIU** Galactomannase 80 HCU** Protein and Peptide Specific Enzymes Acid Protease 20 SAP** Alkaline Protease 20 PC** Protease/Peptidase Complex with endopeptidase, exopeptidase, and DPP-IV activity 16,000 HUT** Fat Specific Enzyme Lipase 6,000 LU** Other Enzymes Serratia peptidase (enteric-coated)*** 1,000 SPU** *Daily Value not established. Other ingredients: Xylitol, mannitol, stearic acid, silicon dioxide, and natural cherry flavor. **Units are those used in edition five (V) of the Food Chemicals Codex (FCC) ***Peptizyme SP, a registered trademark of Specialty Enzymes NOTE: Vital-Zymes Chewable does not contain lysozyme. K-VCH 180 chewable tablets

3 Formulated for Maximum Benefit and Tolerance Promotes optimal GI function and digestive comfort. Enzymes in Vital-Zymes Complete can improve intestinal function, providing temporary relief from flatulence, heartburn, and other digestive complaints. By facilitating more complete breakdown of macronutrients, this comprehensive group of enzymes supports improved nutritional status and reduces the potential adverse effects of food components such as incompletely digested casein, gluten, and lactose. Vital-Zymes Complete may be helpful for individuals with maldigestion, malabsorption, dysbiosis, and intestinal inflammation. Supplies DPP-IV activity specific for breakdown of casein, gluten, and other exorphin peptides. Protein molecules require multiple enzymes for complete digestion. Proteases degrade proteins into peptides of 10 to 20 amino acids in length. Peptidases then complete the process by splitting peptides into single free-form amino acids that are used by the body. Incompletely digested peptides from casein (casomorphins), gluten (gluteomorphins), soy, or yeast may adversely affect central nervous system function in some individuals. Vital-Zymes Complete provides ample amounts of peptidase enzymes that express dipeptidyl peptidase IV (DPP-IV) activity that is especially effective in breaking down exorphin (opiate-acting) peptides before they can be absorbed. While enzymes with DPP-IV activity are normally found in the cells lining the intestinal tract, it is thought that many individuals on the autism spectrum may have a deficiency or defect in DPP-IV activity. Figure 1. Peptide cleaving by DPP-IV Supports against carbohydrate intolerance and dysbiosis. Vital-Zymes Complete contains a wide spectrum of disaccharidase enzymes to assist optimal cleaving of sugars including lactose (milk sugar), maltose (from cereal grains), sucrose (table sugar), and amylopectin (starch) molecules into their absorbable monosaccharide forms. Insufficient disaccharidase production by the small intestine can cause carbohydrate malabsorption and physical discomfort. Lactose intolerance is the most common form of carbohydrate intolerance. Incompletely digested sugars or starch can be fermented by pathogenic organisms and may contribute to yeast overgrowth (candidiasis) and dysbiosis. Reduced disaccharidase levels are observed in many children and adults with chronic diarrhea. Children with dyspepsia typically exhibit low activity of duodenal maltase, glucoamylase, and/or disaccharidases. Helps protect GI tissue from inflammation. Inflammation of gastrointestinal tissues results from various causes such as undigested or partially digested food, ingested or endogenous toxins, intestinal pathogens, and exposure to allergenic substances. In addition to facilitating more complete digestion of potentially irritating food components, Vital-Zymes Complete supplies Serratia peptidase, a unique endopeptidase enzyme that helps protect sensitive gastrointestinal tissue from irritation and subsequent inflammation that can adversely affect tissue health and intestinal comfort. Helps support microbial balance. Vital-Zymes Complete also contains lysozyme, an antibacterial enzyme found in tears, human breast milk, saliva, and nasogastric and bronchial secretions. Lysozyme promotes protective barrier function in these tissues against infectious pathogens by degrading polysaccharides found in the cell walls of many bacteria, yeast, and other pathogens. In the gastrointestinal tract, lysozyme s action helps support a balanced microbial population and complements the benefits of the other enzymes in supporting intestinal health. NOTE: Lysozyme is a highly purified, pharmaceutical grade material derived from hen egg white. While typically well-tolerated, those with classic IgE mediated egg white allergy should consult with a physician before use. Vital-Zymes Chewable does not contain lysozyme for those who may wish to avoid taking it. Protease enzymes in Vital-Zymes Complete first cleave intact casein molecule to split off -casomorphin fragment, an opiate-acting peptide. Enzymes with DPP-IV peptidase activity then cleave -casomorphin after the first proline linkage forming di- and tripeptides with no opioid activity. Statements made herein have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

4 Well-tolerated, hypoallergenic. Contains highly purified, pharmaceutical grade enzymes to meet the needs of sensitive individuals. Free of all maltodextrin (wheat, rice, or corn derived) commonly used as a base in digestive enzyme supplements. Avoids fruit derived enzymes (bromelain, papain, and kiwi) for tolerance by those with pheno-sulfurtransferase issues. Suitable for children or adults. Provides an array of enzymes that encourages maximum digestion of protein, carbohydrates, sugar, fat, and fiber. Two capsules or chewable tablets effectively support digestion of a full range of foods as found in a typical meal. Readily adjusted for individual needs, including smaller or larger meals. Active throughout the GI tract. Contains microbial-based enzymes tolerant of a wide range of ph from 2 (very acidic) to 10 (alkaline), thus exerting benefit throughout the entire gastrointestinal tract. Free of porcine or other animal-derived enzymes that are easily denatured by stomach acid. Enzyme Function Chart Enzyme Type Enzyme Function Carbohydrate-Specific Enzymes Sugar-Specific (Disaccharide) Enzymes Vegetable/Fiber-Specific Enzymes Protein and Peptide-Specific Enzymes Fat-Specific Enzymes Specialty Enzymes Amylase, Alpha-Amylase Glucoamylase Lactase Maltase Sucrase (Invertase) Pullulanase Cellulase, Hemicellulase Alpha-Galactosidase Pectinase Phytase Beta-Glucanase Galactomannase Acid and Alkaline Protease Peptidase and Dipeptidyl Peptidase IV (DPP-IV) Lipase Lysozyme (highly purified from egg white) Serratia Peptidase Converts complex starch in root vegetables and grains into maltose (a disaccharide), maltotriose (a trisaccharide), dextrins, and oligosaccharides Converts maltose, maltotriose, and oligosaccharides into glucose Converts lactose (milk sugar) into glucose and galactose Digests maltose in malt, cereal grains, and processed foods into glucose Converts sucrose (table sugar) into glucose and fructose; forms sucrase-isomaltase complex in the intestinal lining that breaks down dextrins Breaks down amylopectin starch molecules resistant to degradation that may otherwise remain trapped in the microvilli and contribute to inflammation Liberates nutrients from fruits and vegetables, making them more bioavailable Breaks down hard-to-digest carbohydrates found in legumes and cruciferous vegetables Hydrolyzes pectin; reduces the bulking effect of some fibrous foods Breaks down phytates in grains (wheat, oats, barley) and legumes Breaks down glucans in cereal grains and in yeast cell walls Degrades hemicellulose, cellulose, and cell walls with mannose Breaks down plant, vegetable, and meat derived proteins Breaks down casein (dairy products) and gluten (wheat, barley, rye) and their exorphin peptides Hydrolyzes fats in meat and dairy products, oils in nuts and seeds, and triglycerides Degrades polysaccharides found in the cell walls of many bacteria, yeast, and other pathogens Breaks down casein protein peptides; breaks down fibrin and protects sensitive GI tissues from irritation and inflammation

5 Healthy Digestion: Essential for Optimum Nutrition and Health. Almost everyone has experienced digestive discomforts such as gas, bloating, indigestion, gastric reflux, constipation, or diarrhea at one time or another. Eating the wrong foods, overeating, undue stress, or intestinal infections are among the common causes. While such problems are occasional for most of us, impaired digestion and its adverse health consequences can be frequent and troublesome problems for others. When the digestive process malfunctions, malabsorption of nutrients affects overall health and can potentially lead to intestinal dysbiosis and other unhealthy conditions. Undigested or partially digested food can putrefy in the gut and produce toxins that may then leak into the bloodstream, causing fatigue, headache, or behavioral symptoms. Irritation and inflammation occur, leading to an increase in intestinal permeability, or "leaky gut." Undigested protein molecules that cross the intestinal lining may trigger immunological reactions such as allergies, asthma, and skin rashes. Using Supplemental Enzymes for Maximal Digestive Support. A healthy digestive system secretes acids and enzymes that break down foods into the most basic components needed to nourish the body. A variety of different enzymes, each with unique cleaving actions, are required for optimal breakdown of foods. Enzyme production is a key part in the digestive process that is especially susceptible to malfunction. Certain health conditions may adversely affect the body s ability to produce its own enzymes, resulting in fewer enzymes or diminished secretion of enzymes by the pancreas, stomach, and brush-border membrane of the small intestine. When endogenous enzyme production is compromised, ingestion of supplemental enzymes such as protease, amylase, and lipase can help efficiently digest food and alleviate occasional digestion-related discomforts. However, individuals with more complex digestive issues may require enzymes with greater specificity to most fully support digestion of problematic food components such as casein, gluten, and lactose and other disaccharides and to lessen related irritation and inflammation in the intestinal tract. Vital-Zymes Complete provides a comprehensive group of enzymes to specially support individuals with maldigestion, malabsorption, dysbiosis, and intestinal inflammation.

6 Vital-Zymes Complete Multi-Enzyme Supplement for Intensive Digestive Support Potent, 20-Enzyme Formula Supplies DPP-IV Activity Capsule and Chewable Options For Children or Adults Hypoallergenic ABOUT PROTHERA, INC. ProThera, Incorporated manufactures a complete line of nutraceutical products from the brands healthcare professionals trust and recommend with confidence. Products are designed for clinical application and are available exclusively through healthcare professionals. Full private labeling and custom manufacturing services are available. ProThera, Inc. is a subsidiary company of Soho Flordis International Pty Ltd. OUR BRANDS SUGGESTED USE Capsules: Children: 2 capsules per meal or as directed by a physician. Adults: 2 to 4 capsules per meal. Capsules may be opened and contents mixed in a small amount of food or beverage followed by ingestion of regular food. Should not be mixed with hot food or beverage as this may reduce enzyme activity. For best results it is recommended that the enzymes be taken at the beginning of each meal. Dosing should be based on the amount of foods ingested. Young children may start with 1/3 to 1/2 capsule. Older children may start with a full capsule per meal. These amounts can be gradually increased over a period of a week or two to reach the suggested dose. Chewable Tablets: Chew 2 or more tablets at the beginning of each meal or as directed by a healthcare practitioner. ADVERSE REACTIONS None reported. No upper limit has been established for oral enzyme supplementation. Animal studies indicate that extremely large doses of enzymes may be ingested without toxicity or adverse effect. Dosing is based on the amount of food ingested (content and size of a meal) and not specifically by body weight or age. When mixing capsule contents in foods, avoid contact with eyes and inhalation of powder as it may cause some irritation to mucus membranes. CONTRAINDICATIONS Large amounts of proteolytic enzymes should not be taken in the absence of normal gastric mucosa. Do not use if gastritis, peptic ulcer, or heartburn is present. If pregnant or nursing, consult your healthcare practitioner prior to use. This product may not be appropriate for those with known allergies to Aspergillus enzyme proteins, though non-specific mold allergies do not necessarily preclude use of fungal-based enzymes. Lysozyme is derived from egg white protein and is highly purified. However, this product may not be appropriate for those with classic allergic reactions (IgE mediated) to egg white. DRUG INTERACTIONS Carbohydrases may increase intestinal glucose absorption and may thus interfere with the efficacy of oral hypoglycemic drugs or insulin. PRODUCT SUPPLY Vital-Zymes Complete: 120 vegetarian capsules per bottle. ProThera brand integrated formulas build upon versatile multiple vitamin/mineral supplements with focused multi- and single-ingredient products to address a variety of metabolic concerns. Klaire Labs brand specializes in hypoallergenic pre- and probiotics, enzymes, and specialty formulas for GI and immune support that can be used with confidence by individuals who are hypersensitive to various foods and environmental agents. Complementary Prescriptions brand centers on a modular concept that utilizes foundational products for total wellness, protocol formulas for targeted support, and synergistic antioxidants, hormones, and energizers to create effective anti-aging programs. CONTACT US Double R Blvd, Reno, NV ProThera, Inc. operates a GMP 9000 registered facility certified by NSF International, an independent, third-party certification organization. GMP 9000 registration integrates both ISO 9001 and GMP registration. Vital-Zymes Chewable: 180 chewable tablets per bottle. Statements made herein have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. Order Today! protherainc.com Available exclusively through licensed healthcare professionals. Free, 2-day private labeling with 12-bottle minimum order. Copyright ProThera, Inc. Reno, NV All rights reserved. KVZMPROFBROC073015w