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1 Name address DEL FABBRO MASSIMO UNIVERSITÀ DEGLI STUDI DI MILANO, DIPARTIMENTO DI SCIENZE BIOMEDICHE, CHIRURGICHE, ODONTOIATRICHE. SEDE: IRCCS ISTITUTO ORTOPEDICO GALEAZZI, VIA R. GALEAZZI 4, 20161, MILANO, ITALY Telephone Fax Dr. Massimo Del Fabbro. Born in Milan on April 24th, 1964; nationality: italian. Work address: Department of Biomedical, Surgical and Dental Sciences, IRCCS Galeazzi Orthopaedic Institute, Via R. Galeazzi 4, 20161, Milan, Italy. Current position: Associate Professor, Faculty of Medicine and Surgery, University of Milan. He graduated in Biology (BSc) in 1989 at the University of Milan. In 1994 he achieved his PhD in Human Physiology. From 1995 to 1997 he awarded a post-doctoral fellowship whose research activity was focused on the physiopathology of interstitial tissues. From 1999 to 2002 he won a research fellowship for a study titled physiopathology of periodontal and peri-implant tissues. In 2002 he became Academic Researcher for the discipline: oral diseases for the Faculty of Medicine and Surgery of the University of Milan. From 2002 he is head of section of Oral Physiology in the Department of Health Technologies (Director: Prof. R. Weinstein) in Galeazzi Orthopaedic Institute of Milan. From 2003 he is a member of the faculty board of the PhD program in Oral Implantology and Implantprosthesis and afterwards also of the PhD School in Physiopathological, Neuropsychobiological sciences and life-cycle care; both of them at the University of Milan. From 2005 he is a member of the SICOI National Commission Guidelines (Italian Society of Oral Surgery and Implantology) for the guidelines definition regarding: maxillary sinus elevation procedures and alternative therapies and osteonecrosis of the jaws in patients under bisphosphonate treatment: prevalence, causes and guidelines for the clinical approach of this complication. From 2005 he is a reviewer of the Cochrane Collaboration (Cochrane Oral Health Group, Manchester) where his primary activity is to conduct and coordinate Cochrane systematic reviews in the field of Dentistry. From 2005 and 2007 he was a member of the Scientific Board and Chief Scientific Officer Assistant of the Galeazzi Orthopaedic Institute. In 2008 he participated at the Working Group for the definition of the guidelines for Quality in Scientific Research, in Verona, supported by the Italian Society of Osseointegrated Implantology. From 2008 to date he is member of the Scientific Board of the Research Centre for Oral Implantology, University of Milan (Director: Prof. L. Francetti) From 2008 to 2011 he is member of the Scientific Board and, from May 16, 2011 to date he is Director of the Research Centre for Oral Health, University of Milan. From 2011 he is a member of CiMaINa (Interdisciplinary Centre of Nanostructured Materials and Interfaces. Director: Prof. P. Milani) Since 2011 he is project reviewer for the MIUR (Italian Ministry of University and Research). Since he is member of the faculty board of the PhD in Oral Sciences of the Università degli Studi di Milano Since March 1, 2015 he is Associate Professor in Dentistry at the Università degli Studi di Milano Research activity Main research field: interstitial tissue physiology and fluid exchange in the microcirculation, interstitial edema physiopathogenesis, periodontal and peri-implant tissues pathophysiology, evaluation of the effectiveness of surgical techniques through systematic reviews and meta-analysis, biology of the osseointegration, biochemistry and sport hematology, of bone regeneration techniques and tissue engineering in particular combined with platelet concentrates.

2 He is responsible for the study design, data management, statistical analysis and data interpretation and of the reporting of a great number of clinical studies in the field of Dentistry. Principal Investigator of several National and International research projects focused on the evaluation of tissue regeneration procedures, including: - Set up of a model for quantitative analysis of periodontal conditions (COFIN 2001) - Pathophysiology of periodontal tissues (Grandi Attrezzature/Large equipments 2001) - Evaluation of Bone Turnover in periodontal disease (FIRST 2003) - Evaluation of the markers of Bone Turnover around dental implants (FIRST 2003) - Evaluation of the effect of bisphosphonates on endosseous implants osseointegration (FIRST 2004) - Clinical and histological pilot study in order to evaluate the effectiveness of the Bone Morphogenetic Protein 7 (BMP-7 o OP-1) associated to Bone Marrow in maxillary sinus graft (FIRST 2004) - Histological evaluation of the effect of piezoelectric bone surgery compared to conventional bone surgery. (FIRST 2005) - Cellular and molecular markers in PRP (platelet-rich plasma) from patients with osteo-articular pathologies. (2007, Finalized Research IRCCS, Funded by Ministry of Health) Head Prof. G. Banfi - Evaluation of xenografts efficacy in endodontic surgery. (Research Project 2008 IRCCS) - Randomized study on the effectiveness of platelet growth factors associated with guided tissue regeneration (GTR) in endodontic surgery for the treatment of large periapical lesions (PUR 2008) - Randomized Clinical Trial on the efficacy of PRGF in combination with immediate implant placement for the treatment of infected post-extraction sites. (PUR 90% 2009) - Evaluation of the performance of short implants as compared to maxillary sinus augmentation procedure for the rehabilitation of edentulous posterior maxilla, using plasma rich in growth factors" (randomized clinical trial approved by the ASL Ethics Committee of Milan) (Research Project 2010 IRCCS) - National referent of the Eurostars European Project: BioBone: In-Situ formed Biomimetic Biomaterial for Bone Regeneration (2010). In collaboration with BTI Biotechnology Institute (Spain, Main Partner) and BioEngineering Laboratories (Italy). Teaching committments. Lecturer and coordinator of integrated courses in four degree programs at University of Milan: Medicine, Dentistry, Dental Hygiene, Medical Biotechnology and Molecular Medicine (topics: periodontology, implantology, osseointegration and bone biology, physiology of bone grafts, biomaterials for bone regeneration, transplantation and tissue engineering in dentistry). Lecturer of the Specialization School in Oral Surgery (University of Milan), Lecturer of the PhD School: Physiopathological, Neuropsychobiological sciences and life-cycle care (University of Milan), PhD in Dental Sciences, PhD in Nanotechnology (European School of Molecular Medicine, Milan). Lecturer and/or coordinator of the post-graduate Perfectioning Courses in "Periodontology Updates (2002/3-2003/4); New trends in Oral Implantology (2002/3-2005/6); Modern trends in endodontics and endodontic surgery (2005/ / 8); Introduction to clinical research in dentistry, organized in collaboration with the Inter-Faculty Centre Thomas Chalmers (2009/10). Lecturer in the Master in "Health professions coordination tasks" (LIUC University, Castellanza, Varese, from 2006/7 to date); Special Courses: Scientific research in biomedical sciences (2003/4 2004/5); Smoking and Periodontium (2004/5-2006/7); advisor and supervisor of several PhD and degree theses. Guest opponent for a PhD thesis at the Department of Biomedicine, University of Bergen (Norway). Editorial activity Referee and Editorial Board member of several national and international journals. Board member and referee: Italian Oral Surgery, Minerva Stomatologica, Giornale Italiano di Endodonzia, The Journal of Implant and Advanced Clinical Dentistry, Journal of Osseointegration, The International Journal of Periodontics and Restorative Dentistry, Journal of Osteology and Biomaterials, ISRN Dentistry, Implant News, Dataset Papers in Medicine, The Scientific World Journal - Guest Editor of the Special Issue on "Tissue Engineering in Dentistry and Oromaxillofacial Surgery". Guest referee for other international journals: Clinical Oral Implants Research, The Journal of Periodontology, Journal of Applied Oral Sciences, American Journal of Physiology-Heart & Circulation Physiology, Indian Journal of Dental Research, European Journal of Oral Implantology, Clinical Implant

3 Dentistry and Related Research, Clinical Advances in Periodontics, International Journal of Dentistry, The Journal of Obstetrics and Gynaecology Research. Member of: Italian Society of Endodontics, Italian Society for the Study of Bisphosphonates in Odontostomatology; Founder member and member of the Directory Board of the Academy of Non Transfusional Hemocomponents (ANTHEC). National and International Academic Collaborations: Biomedical Engineering Department, University of Michigan, Ann Arbor (USA), Bergen University (Norway), Institute of Odontology, Sahlgrenska Academy, University of Gothenburg (Sweden), Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University (Israel), Department of Periodontology and Implant Dentistry, College of Dentistry, New York University, New York (USA), Department of Medicine, University of Rochester, Rochester, NY (USA), Department of Cranio-cervicalfacial Anatomy, University of Paris 5-René Descartes & UFR d'odontologie, Paris 7-Denis Diderot (France), Department of Stomatology and Oral Surgery, University of Geneva, School of Dental Medicine, Geneva, (Switzerland), Department of Oral Implantology, Medical University of Gdansk (Poland), Faculty of Sport and Physical Education, University of Belgrade (Serbia), Department of Oral Implantology, University of Buenos Aires (Argentina), Catholic University of Uruguay, Montevideo (Uruguay), University of Santa Maria, (Brasil), Department of Health Sciences and Human Biology, University of Corsica, Corte (France), Department of Bioengineering, Politecnico di Milano (Italy), Dental School, University "G. d'annunzio" of Chieti-Pescara, Chieti (Italy), Department of Endodontics, Dental School, University of Turin, Torino (Italy), Oral Surgery Department, Dental School, University of Turin, Torino (Italy), Research Centre for the Study of Periodontal and Peri-Implant Diseases, University of Ferrara (Italy), Department of Odontostomatological, Orthodontic and Surgical Disciplines, Second University of Naples, Naples (Italy), Department of Morphological and Biomedical Sciences, University of Verona (Italy), Interdisciplinary Centre of Materials and Nanostructured Interface, University of Milan (Italy). Collaborations with national and international manufacturers: Geistlich Biomaterials (Switzerland), Nobel Biocare AB (Sweden), Astra Tech (Sweden), Biomet 3i (USA), BTI Biotechnology Institute (Spain), Biom'up (France), IDI Implant Diffusion International (France), EMS Electro Medical Systems (Switzerland), Dentsply Maillefer (Switzerland), Curaden Healthcare (Italy), Dental Tech (Italy), OGNA Laboratori Farmaceutici (Italy), Simit Dental (Italy), EON Medica (Italy), Biomaterials Clinical Research Association, Lucca (Italy). Author of over than 280 publications, of which more than 180 indexed in PubMed (06/2015), in different fields: periodontology, implantology, endodontics, applied physiology, cell and molecular physiology, biochemistry, laboratory medicine, hematology, sports medicine, orthopedics, bioengineering. The overall impact factor is 370. Author of three Cochrane reviews plus two Cochrane protocol (full review in progress). Guest Editor of the Special Issue "Maxillary Sinus in Relation to Modern Oral and Maxillofacial Surgery" for the International Journal of Dentistry. Co-editor of several books: Maxillary sinus Surgery and alternatives in treatment. Eds. Testori T, Del Fabbro M, Weinstein R, Wallace SS. Quintessence International, 2009 Il carico immediato. La nuova era dell'implantologia orale. Eds. Testori T, Galli F, Del Fabbro M. ACME, January 2009 (Italian) Immediate Loading. A new era in Oral Implantology. Eds. Testori T, Galli F, Del Fabbro M. Quintessence, June Author of 15 chapters for several books and monographs: - Chirurgia Implantare (Implant Surgery), Ed L. Malchiodi: Martina Bologna, 2003 (Italian) - Immediate functional loading and osseointegration. A clinician guide. Eds. Trisi P, Salama M, Salama H. Quintessence Publishing, Co., La chirurgia del seno mascellare e le alternative terapeutiche (Maxillary sinus surgery and alternatives in treatment). Eds. Testori T, Weinstein R, Wallace SS.

4 ACME Promoden, Milan, (Italian) - L'endodonzia nel terzo millennio (Endodontics in the third millennium: safe, reliable, predictable. From research to clinic). Ariesdue, (Italian) - Manuale di Chirurgia Orale (Guide to Oral Surgery): Ed SICOI (Italian Society of Oral Surgery and Implantology), 2011 (Italian) - Endodonzia (Endodontics), Ed SIE (Italian Society of Endodontics), 2011 (Italian) Editor of the Italian version several books: Clinical Periodontology and Implant Dentistry. Lindhe J, Karring T, Lang NP, Edi Ermes, 2009 Common Medical Conditions. A Guide for the Dental Team. Bain SC, Hamburger J, Scully C, Edi Ermes 2010 Endodontology. Bergenholtz G. Edi Ermes 2012 Invited Speaker at national and international courses and conferences, including, in recent years: : A critical literature review: clinical and operational aspects. Sinus Lift Forum. Osteology, Turin : Literature review on the predictability of implant treatment. 49th Congress of Brugg's Friends, Rimini : Magnification devices in endodontic surgery. Session: New approaches in Oral and Maxillofacial Surgery, & Success rates of surgical versus non-surgical endodontic therapy. Session: Where is the line between Endodontics and Surgery? Prague Dental Days, Prague : Review of the literature on immediate loading. Consensus Conference on Immediate Loading, Milan, Italian Society of Oral Surgery : Systematic reviews in dentistry. Workshop: Systematic reviews of the literature: what are they and how to prepare. Conference: The Fall EXPO, Assago (MI) : Implants in the aesthetic zone: does immediate loading allow for optimal outcomes regarding functional and aesthetic? 16th European Association for Osseointegration (EAO) Annual Congress, Barcelona, Spain : Is immediate loading of dental implants a clinical reality? Literature review. International Congress: Immediate loading in Oral Implantology. Current therapeutic trends in the aesthetic and functional rehabilitation. Milano : How implant surface and graft materials affect implant survival rate after maxillary sinus augmentation. An updated systematic review. International Health Forum, Fes, Morocco : Post-extractional implants: Literature review. New Procedures and latest information in Implantology. 20éme Congres des 10h de l'implantologie, Paris : What indications can be drawn from the literature about the maxillary sinus lift? A systematic review based on evidence. News in Implant Dentistry. III National Congress Oralplant, Venice, Mestre : Biological and biomechanical aspects of immediate loading. Analysis of the literature. Immediate Loading: The new era of oral implantology. ACME Conference, Milan : What indications does the literature provide on the maxillary sinus lift? A systematic review based on evidence. Advanced training course on the maxillary sinus lift. Chieri (TO) : Healing process in oral surgery. EMS Day: Oral Surgery 2010: methods, procedures and technologies. Milan : Effectiveness of the maxillary sinus lift techniques. The scientific evidence. Current Concepts Course SIO (Italian Society of Osseointegrated Implantology). Clinical approaches to the Maxillary sinus elevation. Como : Procedures in Surgical Endodontics. One-Day Lecture, Department and Clinic of Endodontology, Institute of Odontology, Sahlgrenska Academy, University of Gothenburg, Sweden : Immediate loading of Dental Implants. 4-hour International Course. IN 2011 Latin American Osseointegration Congress. Expo Center Norte, Sao Paulo, Brazil : Tissue Engineering in Dentistry, Seminar. PhD in Medical Nanotechnology, European School of Molecular Medicine (SEMM), Milano : Transalveolar Sinus Lift Augmentation: Modern Approaches ; & Immediate Post-Extraction Implants in Infected Sites. Two-Day Lecture, Current Concepts in American Dentistry: Implantology/Oral Rehabilitation, Linhart Continuing Dental Education Program, New York University College of Dentistry, New York Master in Implantologia Orale. Moderne tendenze in implantologia: miti commerciali o reali opzioni

5 terapeutiche per curare meglio i nostri pazienti? 6 incontri con didattica frontale e sessioni video. IRCCS Istituto Ortopedico Galeazzi, Milano. Coordinatore Scientifico e Relatore: M. Del Fabbro The use of platelet concentrates for tissue regeneration in oral surgery. The present and the future. Invited Seminar, University of Bergen, Bergen, Norway Le revisioni sistematiche in Odontoiatria. Invited Seminar. Dental School, Lingotto, Torino Protocolli innovativi per la riabilitazione implantare del mascellare superiore atrofico mediante fattori di crescita autologhi. Evidenze scientifiche e procedure operative. BTI Day, Cavenago di Brianza (MB) Efficacia delle diverse opzioni terapeutiche Congresso del Collegio dei Docenti di Odontoiatria aprile 2013 Seno mascellare e impianti: opzioni terapeutiche a confronto Utilizzo dei concentrati piastrinici nella moderna riabilitazione impiantare SICOI Congress - Milano, 26/10/2013, SICOI Limited Attendance Lectures: Derivati ematici in chirurgia implantare Preparation of the implant site using a single bur: biological concepts and surgical outcomes. 10 Hours of Implantology Congress, Paris, France Principi di Rigenerazione tissutale in odontoiatria. Un update In: Nuove opzioni per il mascellare edentulo corso con prof. Hendrik Terheyden (Univ. Kiel, Germany), Istituto Ortopedico Galeazzi, Milano 16/11/ Revisione sistematica della letteratura sulle riabilitazioni a carico immediato. In Carico immediato: dalla sperimentazione alla clinica. Novità e riflessioni. XXVI Giornate di Implantologia, Cenacolo Milanese, Milano 28/2/ Modern approaches in implant dentistry to improve treatment outcomes and management of biological complications. Invited lecture 30/05/2014, Tel Aviv University, Tel Aviv, Israel Aggiornamento della letteratura: Odontoiatria II Congresso Nazionale ANTHEC Emocomponenti a uso non trasfusionale: stato dell arte e applicazioni multidisciplinari, Cremona Novembre Endodontic Microsurgery 1: How do I assess the indications and evidence for or against endodontic microsurgery? SSE Annual Conference, Lucerne, Switzerland, January Impianti Centralized Platform: risultati di uno studio prospettico multicentrico e Evaluation of new implant dental surfaces: an animal model study. Congresso Ricerca scientific e nuove tecnologie al servizio dei clinici e dei loro pazienti: sinergie tra Università e Aziende. Istituto Ortopedico Galeazzi, Milano, 28/02/ Evidenza scientifica sugli emocomponenti ad uso non trasfusionale Workshop Aggiornamenti in Chirurgia Orale: uso dei concentrati piastrinici come coadiuvanti della guarigione dei tessuti duri e molli XXII Congresso Naz. Collegio dei Docenti Milano 9-11 aprile Cosa sono e come si fanno le revisioni sistematiche in Workshop Le basi fondamentali delle revisioni sistematiche della letteratura XXII Congresso Naz. Collegio dei Docenti Milano 9-11 aprile 2015