Dear colleagues and friends,

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1 Universitätsklinikum Regensburg, Regensburg Klinik und Poliklinik für Innere Medizin III Direktor: Prof. Dr. Wolfgang Herr Aktenzeichen Unser Zeichen Bearbeiter Telefon 09 41/ Regensburg, Dear colleagues and friends, Up to now, the biggest challenge in allogenic transplantation is to understand and manage the immunology of graft-versus-host and graft-versus-tumor reactions. The GvH/GvL meeting was first organized by Hans-Jochem Kolb in 1994 and it has since been a tradition of this meeting held every two years that the latest achievements are monitored, discussed and put yet another step forward. It is a great pleasure and honour for us to continue this meeting series and host it in the historical walls of Regensburg. Therefore, it is our pleasure to announce the next GvH/GvL meeting 2016, which will be held from March 16 th -18 th at the Thon Dittmer Palais in Regensburg and invite you to join us in March As in the previous meetings we aim to have two days of intensive interaction to discuss and develop upto-date concepts within a small group of invited speakers, chairs and discussants. As in the previous years, we cannot reimburse travel and accommodation, but there will be no registration fee. As the number of participants is strictly limited to 150, we kindly ask you to register as soon as possible. We will not be able to accept unregistered participants due to these reasons, and will inform you, when registration exceeds the number of possible participants. Please feel free to pass this information also to your colleagues who might be interested. We are looking forward to welcoming you in Regensburg in March 2016! Yours sincerely Prof. Dr. Ernst Holler Prof. Dr.Wolfgang Herr Hausadresse Universitätsklinikum Regensburg Franz-Josef-Strauß-Allee Regensburg ÖPNV: RVV Linien 6 und 19 Telefon: 0941 / Telefax: 0941 / [email protected] Universitätsklinikum Regensburg Anstalt des öffentlichen Rechts Vorstand: Ärztlicher Direktor: Prof. Dr. Olliver Kölbl (Vorsitzender) Kaufmännischer Direktor: Dipl.-Kfm. Klaus Fischer Pflegedirektor: Alfred Stockinger Dekan der Medizinischen Fakultät: Prof. Dr. Dr. Thorsten E. Reichert

2 GvH/GvL 2016 Preliminary Agenda (3rd Draft November 2015) Wednesday, March 16, : Welcome and opening 13.05: 1 st Session Mucosal and epithelial Immunology ( ) Chairs: A Dickinson, Newcastle, HJ Kolb, Munich Neutrophils (R Zeiser, Freiburg) (20+5) Lung ( G Hildebrandt, Kentucky) (20+5) New pathways activating TH17 (Hill, Australia) (20+5) Innate lymphoid cells in the skin (Brueggen, Vienna) (15+5) Intestinal DC (Beilhack, Würzburg) (15+5) Organoids as potential GvHD models (Walles, Würzburg) (15+5) Coffee Break: : 2nd session Microbiome (15.30 bis 18.15): Chairs: M Mohty, Paris, A Gerbitz, Berlin Keynote Lecture : Microbiota and GvHD (M v d Brink, New York) (25+5) Methods for assessment and pitfalls (Gessner, Regensburg) (15+5) Metabolomic profiling of microbiota (Oefner, Regensburg) (15+5) Vit D and Microbiome (Cantorna, Pennsylvania) (20+5) Fecal Microbiota Transplantation Lessons from IBD and C Diff (Högenauer, Graz) (15+5) DCs and microbiota ( Hildner, Erlangen) (15+5) 19.00: Evening discussion: Prevention of GvHD did we make progress?

3 Thursday, : 3rd Session: GvHD Biomarkers and Pathophysiology Chairs: J Halter, Basel, K Fleischhauer, Essen Keynote Lecture: HLA DP and GvHD (Petersdorf*, Seattle) (25+5) Acute GvHD (Ferrara, New York) (20+5) Chronic GvHD (Greinix, Graz) (20+5) Endothelial Markers (Luft, Heidelberg) (20+5) Tweak FN14 (Waijant, Würzburg) (20+5) Alpha1antitrypsin and GvHD (Deeg, Seattle) : Coffee Break : 4th session Regulatory cells: Chairs: A Madrigal, London; Regensburg, P Winkler, Erlangen inkt (Schneidawind, Tübingen) (20+5) MDSCs (Jitschin, Erlangen) (20+5) Fatty acid metabolism and T regs (Sparwasser, Hannover) (20+5) T reg in acute GvHD (Edinger, Regensburg) (20+5) T regs in chronic GvHD (Forjaz Lacerda, Portugal) (20+5) B regs (C Mauri, London) (20+5) Lunch Posttransplant Cyclophosphamide where do we stand and go Chair: E Holler, Regensburg L Luznik The Baltimore experience (30+10) th session: Modulation of GvL Chairs: A Mackensen, Erlangen, H Einsele, Würzburg Checkpoint inhibitors and GvL (Dolstra /Nijmegen) (20+5) Checkpoint modulators and immune escape (Beckhove) (20+5) Checkpoint agonists (CD27) (Chakraverty, London) (20+5)

4 : Coffee Break 16.20: 5 th session (continued) Influence of oxidative stress on GvL (Mougiakakos, Erlangen) (20+5) Immune escape in leukemia loss of mismatched HLA (Vago, Milano) (20+5) : Short presentations of selected abstracts (8 min presentations) Friday, March : HJ Kolb Award Introduction and Lecture th session: Targets and effectors for GvL Chairs: M Bornhäuser, Dresden, W Herr, Regensburg Keynote lecture: TCR gene therapy in the setting of allogeneic SCT (M Heemskerk, Leiden) (25+5) CARs in the contex of allogeneic SCT (Rossig, Düsseldorf) (25+5) Coffee Break th session continued Natural killer cells (Miller JS, Minnesota) (25+5) Immunotherapy in AML bispecific antibodies (G Jung, Tübingen) (20+5) Naturally processed AML and CLL peptide Targets (Stickel J., Tübingen) (20+5) Cars against leukemia (Bondanza; Mailand) (20+5) Summing up and end of meeting

5 REGISTRATION FORM GvH/GvL 2016 March, 16 to 18, 2016 Thon Dittmer Palais Regensburg I want to participate at the GvH/GvL 2016 I will not be able to participate at the GvH/GvL 2016 Family name/first name Hospital/Institute/Company Department Street, No. Postal code City Country Phone Fax ACCOMMODATION Please check your contact details stated above and correct / complete where necessary We kindly ask to make your reservations via the General tourist and hotel information: Tourist-Information Altes Rathaus Rathausplatz Regensburg Germany Tel.: +49-(0)941/ Tel.: +49-(0)941/ TRAVEL DETAILS Arrival : by plane, please organize airport transfer From To Date Flight number/ Arrival Time Departure: by plane, please organize airport transfer From To Date Flight number/departure Time Please organise your travel yourself. Transfer from the airport if requested will be organized by us. Please indicate whether you want to participate at the Social Dinner at the Danube cruising ship "Kristallprinzessin", Thursday, March 17,2016 yes no Please complete this form and return it before January 31, 2016 to Susanna Blüml Dept. of Hematology and Oncology University of Regensburg F.J. Strauss Allee 11, Regensburg, Germany Phone: Fax: [email protected]

6 Hans Jochem Kolb Research Award 2014 Call for applications The scientific committee of the upcoming biannual conference on GvH/GvL is pleased to offer the Hans Jochen Kolb research award ( ) for outstanding contributions in the field of hematopoietic stem cell transplantation immunology, especially biology of graft-versushost disease and graft-versus leukemia reactions. The award is supported by an educational grant from Fresenius Biotech GmbH, Gräfelfing. The selection will be undertaken by the scientific comittee of the meeting under the supervision of Prof. Dr. Hans Jochem Kolb. The award will be presented in Regensburg at the GvH/GvL meeting in March To apply for the award candidates should submit a paper published or accepted for publication during the year 2014 or The candidates should not be older than 40 years. Applications for the award should include the paper and a CV and be submitted by to Professor Ernst Holler via [email protected] by January 31, 2016: