EFFECT OF ESTROGEN AND TESTOSTERONE ON THE GASTRIC SECRETION OF RATS AND CONCIOUS RABBITS B.B. MAITRYA. S. GAHLOT AND B. MAITRYA
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1 EFFECT OF ESTROGEN AND TESTOSTERONE ON THE GASTRIC SECRETION OF RATS AND CONCIOUS RABBITS B.B. MAITRYA. S. GAHLOT AND B. MAITRYA Department of Phvsioloqv and Biochemistry, Sardar Patel Medical College, Bikaner Summary: Shay rats and conscious rabbits were used to study the effect of sex hormones on gastric secretion. Daily injections of estradiol-di-propionate and testosterone-propionate were given separately to each set of animals. while the control animals received solvent alone for the same duration of time. Estrogeninhibited gastric acid output but augmented the mucus secretion as evidenced by increased hexosamine and fucose contents; and testosterone had the reverse effects. The effect of estrogen was more potent than that of testosterone. An inverse relationship between gastric acid and mucus secretion hasbeen noted. Peptic activity varied independently of the acid output. These hormones seemed to vary the acid output bv modifying the composition of mucus secretion. Key words: Shay rats hexosamine acid output fucose peptic activity sex hormones glycoproteins augmented histamine stimulated gastric secretion INTRODUCTION A correlation between sex hormones and gastric secretion has been described (1,19). Incat. estrogen was shown to reduce gastric acid secretion (6). No such effect was reported inmonkey (9). dog (7) and rat (5). Under conditions of maximal histamine stimulationmale guineapigs secreted significantly higher amounts of gastric acid than the females(23). Stilboesterol therapy depressed gastric secretion in cats of either sex (17), butnot in dogs (3). Myhre (16) reported that estorgen produced no demonstrable effect on thehealing of experimental gastric ulceration in rats. while Griffen et al. (7) observed that histamineinduced ulcers in dogs were enhanced by it. A promoting effect of female sex hormoneon the development of gastric ulcer has been claimed in pylorus-ligated rats (2). Kowalewskiet al. (12) recorded that androgens enhanced the susceptibility of rat's gastric mucosato peptic action of gastric juice. In view of these conflicting reports regarding the action of sex hormones on gastric secretion,this study was conducted in rats and rabbits. MATERIALS AND METHODS Studies in rats: Normal. healthy, adult albino rats weighing between g wereused. They were divided into (i) male, and (ii) female groups. Each group was
2 106 Maitrya et al. further subdivided into the following subgroups of 10 rats each: (a) Normal. control. (b) Estrogen. and (c) Testosterone. Estrogen rats werei jected im estradiol-di-propionate (Ovocvclin-Ciba). 10 p.g/kg/day. and testosterone trea rats received testosterone propionate (Perandran-Ciba). 100,.,.g/kg/day for 10 days. control experiments the solvent used for dissolving these hormones was injected for the sa duration of time. Gastric juice in 24-hr fasted rats was collected by ligating the cardiaca pyloric ends as described by Shay et al.(20). Kav's augmented histamine stimulated gas secretion (10) was collected for 2 hr and its volume. total acid output (TAO), and pep activity (8) were determined. Studies in rabbits: Normal. healthy, albino. adult rabbits of either sex, weighi between kg fed on Hind Lever feeds and green foliage, were used. 10 rabbits each sex underwent three types of treatments, hence were classified into: (a) normal.(b estrogen. and (c) testosterone animals. Normal group were injected with t solvent of these hormones for 15 days. Then they were injected 20,.,.g/kg/day of Ovocycr for 15 days, and constituted the estrogen group. After this therapy, their gastr' samples were analysed, and they were given a rest for 10 weeks to enable them to rest their normal original gastric parameters. In the third stage, they received 200 ILg/kg/d of Perandren for 15 days, and formed the testosterone group. After each treatment Kav's augmented histamine stimulated gastric secretion (10 was collected from conscious, 24-hr fasted rabbits by passing 3-mm polvthelene tube ora by the technique developed in this laboratory. Gastric samples for 2 hr was collected an pooled. Its volume. free acid output (FAO), total acid output (TAO), pepsin (8), hexosamine (25) and fucose (4) contents were estimated. Under both these groups the animals were not used during estrous. and the dosage and duration of therapy were established after trial and error to yield the optimum results, RESULTS AND DISCUSSION Table I shows that estrogen in male rats caused significant reduction in gastric seen tion volume and its acid output. Similar results were obtained in female rats except for the fact that the volume of gastric secretion was not reduced significantly. In female rats, testesterone produced a significant rise in acid output and a fall in peptic activity but the changes were not Significant in male rats. Table 11 also indicates that estrogen inhibited significantly the volume, free and total acid outputs but augmented the hexosamine and fucose fractions of gastric juice in both the
3 Estrogen, Testosterone and Gastric Secretion 107 TABLE I: Effect of sex hormones on gaslric secretion of rats. Volume ml/2 br TAO meq/2 Peptic activity unitslmt ::...- _ hr FEMALE RATS 0.93±1.210 ( ) 0.026± ( ) 105.5±9.56 (70-150) 0.73±0.101 (05-1.5) 0.011± ( ) 109.9±4.17 (90-134) 0.99±0.127 (08-1.8) O. 035± ( ) 95.8±5.05 (66-120) 0.92±0.190 (0.5...:...2.5) MALE RATS O. 035± ( ) 119.1± (50-192) o 62±0057 (05-1.0) O. 024± ( ) 112.5±9.02 (70-150) 0.94±0 086 o 028 ±O ±12.48 ( ) ( ) (56-180) Total number of rats in each group were 10: Values are Mean ±SE: Figcrres in parentheses indicate the range. "denotes significant p values. sexesof rabbits. Testosterone significantly elevated the FAO in female rabbits and reduced thefucose contents of gastric juice in both the sexes of animals. In both the species of animals studied, estrogen inhibited the gastric secretion and testosteroneaugmented it though the former exercised more potent effect than the latter. Aninverse relationship between gastric acid output and mucus secretion has been noted. Peptc activity varied independently of the acid secretion. Hexosamine and fucose fractions of gastric secretion has been identified as major constituents of gastric mucus and boththese glycoproteins represented biochemically the amount of mucus present in it (12). Dueto lesser volume of gastric secretion in rats. these fractions could not be estimated. Several reports (1,13,19) indicated that estrogen exerted inhibitory effect on gastric secretion,while testosterone had the reverse effect. Our study also corroborated these findings,though contrary results in dogs (24) and rats (2) have been mentioned. and even some
4 103 Maitrva et at TABLE 11: Effect of sex hormones on gastric secretion of rabbits. Ind. J. Group Volume ml/hr fao meg/hl TAO meq/hl Pepsin unitlmt Hexosamine mg/1co ml FEMALE RABBITS Normal 15.1±0.2 (14-16) 0.9±0 3 ( ) 1.1±01 ( ) 45±1.3 (37-51) 14.1±02 ( ) Estrogen 14.1± ±0 1 08±0.1 43± ±1.7 (13-15) ( ) ( ) (37-51) ( ) Testosterone 16.2± ± ±0.2 41± ±0 1 (15-17) ( ) ( ) (31-48) ( ) MALE RABBITS Normal 16.8±0.4 (15-19) 1.2±0.2 ( ) 1.4±0.1 ( ) 45±1.6 (40-55) 14.1±0.1 ( ) Estrogen 14.3±0.3 (13-16) 0.9±0.1 ( ) 0.9±0.1 (0.7-:-1.2) 50±1.8 (38-59) 20.6± ±U ( ) ( Testoster one 164±0.4 (14-18) 1.2±02 ( ) 1.4±0.2 ( ) 48±2.0 (42-60) 13.0±0.3 ( ) 10 rabbits of either sex were used: Values are Mean ±SE: Figures in parentheses indicate range; 'denotes significant p values. authors described them to be without effect in dog (7), monkey (9) and man {18,21). Singh and Shukla (22) demonstrated correlation between sex hormones and gastric mucus secretion. Kowalewski (11) noted diminution in the secretion of mucopolysaccharides in rat's stomach after androgens. Menguy (15) reported that some hormones were known to influence the 'protective gastric mucus barrier' and androgen was labelled to be one of them. There are two mechanisms (14) responsible for bringing about variations in gastric acid secretion: (i) changes in mucus, and (ii) changes in parietal cell mass. In this study estrogen caused reduction in acid output and a rise in mucus secretion, while testosterone produced the opposite effects. These hormones, thus seemed to modify the gastric acid secretion by varying its mucus secretion. Peptic activity, however, varied independently of the acid secretion.
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