Koc University, College of Engineering, Rumelifeneri Yolu, 34450, Sarıyer, Istanbul, Turkey. MSc, Chemical and Biological Engineering

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1 EMINE GUVEN-MAIOROV Nationality Date of Birth Address Mobile Phone E- Mail LinkedIn Turkish Koc University, College of Engineering, Rumelifeneri Yolu, 34450, Sarıyer, Istanbul, Turkey tr.linkedin.com/in/emineguvenmaiorov EDUCATION 09/ / / / / /2009 PhD, Chemical and Biological Engineering Koc University, Computational Systems Biology Group, Istanbul, Turkey Thesis title: Understanding the relation of cancer and inflammation by constructing structural Toll- like Receptor pathway. Supervisors: Professor Ozlem Keskin & Professor Attila Gursoy MSc, Chemical and Biological Engineering Koc University, Computational Systems Biology Group, Istanbul, Turkey Thesis title: Identification of interconnected markers for T- cell Acute Lymphoblastic Leukemia. Supervisors: Professor Ozlem Keskin & Professor Attila Gursoy BS, Molecular Biology and Genetics Bogazici University, Istanbul, Turkey ACADEMIC & PROFESSIONAL EXPERIENCE 09/ / / / / /2013 Research and Teaching Assistant, Koc University, Istanbul, Turkey Guest Researcher, National Cancer Institute, Cancer and Inflammation Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research. Supervisor: Professor Ruth Nussinov Guest Researcher, National Cancer Institute, Cancer and Inflammation Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research. Supervisor: Professor Ruth Nussinov 1

2 06/ / / / / /2009 Guest Researcher, Harvard Medical School, Department of Cell Biology. Supervisor: Professor Robin Reed. Guest Researcher, Harvard Medical School, Department of Cell Biology. Supervisor: Professor Robin Reed. Intern, Bogazici University, Department of Molecular Biology and Genetics. Supervisor: Professor Esra Battaloglu. PUBLICATIONS 1. Guven- Maiorov E, Keskin O, Gursoy A, Tsai CJ, VanWaes C, Chen Z, Nussinov R. The architecture of TIR domain signalosome in Toll- like receptor Signaling Pathway. (Submitted to Scientific Reports). 2. Guven- Maiorov E, Keskin O, Gursoy A, Nussinov R. Structural view of negative regulation of Toll- like receptor- mediated inflammation. (Submitted to Biophysical Journal). 3. Guven- Maiorov E, Acuner Ozbabacan SE, Keskin O, Gursoy A, Nussinov R (2014) Structural Pathways of Cytokines May Illuminate Their Roles in Regulation of Cancer Development and Immunotherapy. Cancers 6: Guven- Maiorov E*, Acuner Ozbabacan SE*, Engin HB*, Kuzu G*, Muratcioglu S*, et al. (2014) The Structural Network of Interleukin- 10 and Its Implications in Inflammation and Cancer. BMC Genomics 15 Suppl 4: S2. (* Equally contributed) 5. Guven- Maiorov E, Keskin O, Gursoy A, Nussinov R (2013) The structural network of inflammation and cancer: Merits and challenges. Semin Cancer Biol 23: Guven- Maiorov E, Keskin O, Ng OH, Ozbek U, Gursoy A (2013) Identification of interconnected markers for T- cell acute lymphoblastic leukemia. Biomed Res Int 2013: In preparation 1. Guven- Maiorov E, Keskin O, Gursoy A, VanWaes C, Chen Z, Nussinov R. Structural insights into the CASP8 interactions, mutations, and their roles in tumorigenesis. 2. Guven- Maiorov E, Keskin O, Gursoy A, Muftuoglu M. Modifying Base- excision repair for therapeutic benefit of neurodegenerative diseases. TEACHING EXPERIENCE Spring 2015 Fall 2014 Spring 2014 Drug Design (CHBI 550) Thermodynamics (CHBI 503) Drug Design (CHBI 550) 2

3 Fall 2013 Spring 2013 Fall 2012 Spring 2012 Fall 2011 Spring 2011 Fall 2010 Spring 2010 Fall 2009 General Biology- I Laboratory (MBGE 101) Drug Design (CHBI- 550) Biochemistry (MEDI 201) Biochemistry (MEDI 201) Introduction to Cellular and Molecular Biology Laboratory (MBGE 202) Cell and Developmental Biology (MBGE 204) Introduction to Cellular and Molecular Biology Laboratory (MBGE 202) General Biology- I Laboratory (MBGE 102) Introduction to Physics (PHYS 101) POSTERS 1. ISMB 14: Structural Toll- like Receptor pathway may illuminate its roles in inflammation and cancer crosstalk, Emine Guven- Maiorov, Ruth Nussinov, Ozlem Keskin, Attila Gursoy, Boston, USA Biophysical Society Thematic Meeting on Modeling Biomolecular Systems, Interactions, Dynamics, and Allostery: Structural Toll- like Receptor pathway may illuminate its roles in inflammation and cancer crosstalk, Emine Guven- Maiorov, Ruth Nussinov, Ozlem Keskin, Attila Gursoy, Istanbul, Turkey International Symposium on Integrating Spectroscopic and Theoretical Methods to Analyze Molecular Machines: Template- based Assembly of TIR- Domain Signalosome in Toll- like Receptor Pathway, Emine Guven- Maiorov, Ruth Nussinov, Ozlem Keskin, Attila Gursoy, Schloss Ringberg in Bavaria, Germany ISMB 11: Identification of Interconnected Markers for T- cell Acute Lymphoblastic Leukemia, Emine Guven- Maiorov, Ozlem Keskin, Attila Gursoy, Vienna, Austria, HIBIT 11: Revealing Temporal and Functional Relations in Breast Cancer Expression Profile Using Biclustering Based Analysis, Emine Guven- Maiorov, Omer An, Ozlem Keskin,Attila Gursoy, Turkey, HIBIT 10: Attacking Interface and Interaction Networks, Billur Engin,Emine Guven- Maiorov, Omer An, Ozlem Keskin, Attila Gursoy, Turkey, 2010 SKILLS & COMPETENCES Language: Programming: English (Fluent), Russian (Beginner), Turkish (Native) Python, Matlab, Unix/Linux 3

4 Protein Visualization Tools: Protein Docking Tools: Discovery Studio, Molsoft, VMD, Chimera, Yasara, Pymol PRISM, Flexpepdock, Cluspro Virtual Screening Tools: Autodock, AutodockVina, Molegro, FRED (OpenEye), GLIDE (Schrödinger), GOLD, CLC drug discovery workbench Microarray Analysis Tools: Expander, Pinnacle- Z Network Visualization Tools: Cytoscape Simulation Tools: Fields of Expertise: Laboratory techniques: NAMD Protein- protein interactions, docking, homology modeling, protein structure and function, structure- based drug design (computer- aided drug design), microarray data analysis PCR, RT- PCR, cloning, electrophoresis (agarose gel, PAGE), DNA/RNA extraction, protein purification, Western blot, cell- culture, micro- injection, sirna transfection, IP, nuclear extract preparation, xcelligence (real- time monitoring of cells without incorporation of labels), dissection of dorsal root ganglia from mice, in vitro systems for coupling transcription- to- splicing in RNAP- II transcripts (invented in Reed lab) WORKSHOPS & CERTIFICATES 1. Drug Design Workshop by Kumlesh K Dev (Supported by Erasmus Program) (2014), Koc University, Istanbul, Turkey 2. Computational Drug Discovery Workshop by Schrödinger (2012), Yeditepe University, Istanbul, Turkey 3. Corporate Relations and Resource Development by Richard Haass (2010), Koc University, The Evolving World Order 4. EMBO Young Scientists Forum in Turkey (2008), Bogazici University, Istanbul, Turkey GRANTS AND AWARDS 1. Merit Scholarship, Koc University, Turkey, Merit Scholarship, Bogazici University, Turkey, Turkish Prime Ministry Undergraduate Fellowship, Istanbul Municipality Undergraduate Fellowship,

5 5. IKEV Undergraduate Fellowship, MEMBERSHIPS 1. ISCB (International Society for Computational Biology) 2. IEEE (Institute of Electrical and Electronics Engineers) 3. TEMA (Turkey Erosion Control, Reforestration & Protection of Nature Foundation) 4. IKEV (Istanbul Karamanlilar Egitim, Kultur ve Dayanisma Vakfi) member of the executive board REFERENCES For the computational skills 1. Professor Ozlem Keskin (PhD Supervisor) Center for Computational Biology and Bioinformatics, Chemical and Biological Engineering, Koc University, Rumelifeneri Yolu, Sariyer Istanbul, Turkey E- mail: Phone: Professor Attila Gursoy (PhD Supervisor) Center for Computational Biology and Bioinformatics, Computer Engineering, Koc University, Rumelifeneri Yolu, Sariyer Istanbul, Turkey E- mail: Phone: Professor Ruth Nussinov Cancer and Inflammation Program, Leidos Biomedical Research, Inc. Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA E- mail: Phone: For the experimental skills 1. Professor Meltem Muftuoglu Department of Molecular Biology and Genetics, Acibadem University, Istanbul, Turkey E- mail: Phone: Professor Robin Reed Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, LHRRB- 501, Boston, MA 02115, USA E- mail: Phone: