Educational Background

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1 CURRICULUM VITAE TOLGA ACUN Nationality : Turkish Birth Place / Date : Ankara, TURKIYE / 1974 Marital Status : Single Address : Department of Molecular Biology and Genetics, Faculty of Sciences and Arts, Bülent Ecevit University, / Zonguldak / TURKEY Office Tel. : (internal: 1778) tolgaacun@yahoo.com tolga.acun@beun.edu.tr Languages : Turkish (Native), English (fluent) Educational Background Ph.D. Bilkent University, TURKEY Department of Molecular Biology and Genetics Supervisor : Prof. Dr. M.C. YAKICIER Thesis Title : Genetic and Epigenetic Evaluation of the Candidate Genes in Human Hepatocellular Carcinomas M.Sc. Middle East Technical University (M.E.T.U), TURKEY Department of Biology Supervisor : Prof. Dr. Fatih IZGU Thesis Title : Isolation and characterization of the K4 type yeast killer toxin [ ] Preparatory School in English at M.E.T.U / TURKEY [ ] Obligatory Military Service B.Sc. Ankara University, TURKEY Department of Biology Professional Positions 2013-(present) Assistant Prof. Dr. Bülent Ecevit University, Dep. of Molecular Biology and Genetics / Turkey 2012 Visiting Scientist (3 months) * Council of Higher Education (Turkey) bursarie Vall d Hebron Research Institute (VHIR), Barcelona / Spain Assistant Prof. Dr. Bülent Ecevit University, Department of Biomedical Engineering / Turkey Teaching/Research Assistantship Bilkent University, Department of Molecular Biology and Genetics / Turkey 1

2 Administrative Duties 2013 Founding Member Undergraduate program of "Molecular Biology and Genetics" Department of Molecular Biology and Genetics, Faculty of Sciences and Arts, Bülent Ecevit University 2013-(present) Institutional Vice Coordinator, Mevlana Exchange Programme / Bülent Ecevit University 2013-(present) Vice Head, Department of Molecular Biology and Genetics 2013-(present) Departmental Coordinator, Erasmus, Farabi and Mevlana Exchange Programmes Vice Head, Department of Biomedical Engineering Research Interests : Cancer genetics, epigenetic mechanisms Publications 1. Soysal Y #, Acun T #, Lourenço CM, Marques W Jr, Yakıcıer MC; (2012), Muscle Hemangiomatosis Presenting As A Severe Feature In A Patient With The PTEN Mutation: Expanding The Phenotype Of Vascular Malformations In Bannayan-Riley-Ruvalcaba Syndrome BJMG, 15/1, 45-50, (2012) (SCI-Expanded) # The first two authors have contributed equally this study Tolga Acun, Emin Oztas, Tamer Yagci, Mustafa C Yakicier; (2011), SIP1 is Downregulated in Hepatocellular Carcinoma by Promoter Hypermethylation BMC Cancer, 11:223, (2011) (SCI-Expanded) Listed as Highly accessed in BMC CANCER (more than 800 download in first 3 weeks) 3. Acun T, Terzioğlu-Kara E, Konu O, Ozturk M, Yakicier MC; (2010), Mdm2 Snp309 G allele displays high frequency and inverse correlation with somatic P53 mutations in hepatocellular carcinoma ; Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis, 68: , (2010) (SCI) 4. Fatih İzgü, Demet Altınbay and Tolga Acun; (2006), Killer toxin of Pichia anomala NCYC 432; purification, characterization and its exo-β-1,3-glucanase activity ; Enzyme and Microbial Technology, 39(4): , (2006) (SCI) 2

3 Manuscripts 1. Tolga Acun, Emin Oztas, M. Cengiz Yakicier; PTPRD is homozygously deleted and epigenetically downregulated in human hepatocellular carcinomas (Manuscript is ready for submission to European Journal of Cancer). Proceedings 1. T. Acun, K. Demir, E. Oztas, M.C. Yakicier; (2012) Genetic and Epigenetic Alterations of PTPRD in Hepatocellular Carcinoma ; European Journal of Cancer, vol. 48, suppl. 5 (2012), ISSN , S25 S288, S123. [22nd Biennial Congress of the European Association for Cancer Research, 7 10 July 2012, Barcelona, Spain] 2. Y. Soysal, T. Acun, C. M. Lourenço, W. Marques Jr, C. Yakıcıer; (2012) Muscle hemangiomatosis as a severe presenting feature in a patient with PTEN mutation: Expanding the phenotype of vascular malformations in Bannayan-Riley-Ruvalcaba syndrome ; European Journal of Human Genetics, Volume 20, Supplement 1, June 2012, page 58, P [European Human Genetics Conference 2012, June 23-26, 2012, Nürnberg, Germany] 3. CB Akyerli, D Agirbasli, T Acun, O Sahin, MC Yakicier; (2010) Analysis of genetic variations caused by environmental factor aflatoxin in hepatocellular carcinoma ; Clinical Genetics 2010; 78 (Suppl. 1): [ Clinical Genetics Special Issue: Abstracts of the 9th National Medical Genetics Congress, 1-5 December 2010, Istanbul, Turkey ] 4. D Agirbasli, CB Akyerli, T Acun, A Keller, MC Yakicier; (2010) Lincrna Expression in Hepatocellular Carcinoma ; Clinical Genetics 2010; 78 (Suppl. 1): [ Clinical Genetics Special Issue: Abstracts of the 9th National Medical Genetics Congress, 1-5 December 2010, Istanbul, Turkey ] 5. M. Yakicier, T. Acun, S. Dizlek, A. Timuragaoglu; (2009) A branched dna-based technique for detection of BCR-ABL gene products ; Haematologica-The Hematology Journal ; 94[suppl.2]:17 abs. 0041, 2009 (14th Annual Meeting of the European-Hematology-Association, Jun 2009, Berlin, Germany) 6. Tolga Acun, Ece Terzioğlu, Ozlen Konu, Mehmet Ozturk and M. Cengiz Yakicier; (2007) MDM2 SNP309 G allele and TP53 mutations are mutually exclusive in human hepatocellular carcinomas ; ILCA Annual Conference, Book of Abs., p.21, Oct. 2007, Barcelona / Spain 7. Acun T. and Yakicier M.C.; (2006) "Genetic analysis of hepatocellular carcinoma candidate tumor supressor genes and oncogenes"; FEBS Journal Volume 273, Issues1, Page , Jun 2006 (31 st FEBS Congress,"Molecules in Health and Disease", June 2006, Istanbul / Turkey) 8. F.İzgü, D. Altınbay, T. Acun; (2003) Isolation and characterization of K4 type yeast killer protein ; Society for General Microbiology, 153rd Meeting, 2003, UMIST, Manchester. 3

4 Other Congress & Workshops Bioinformatics for AntiCancer Drug Discovery Workshop, October 2011, Bilkent Üniversitesi, Ankara / Turkey Sumru Bayın, Zeynep Tokcaer Keskin, Tolga Acun, Mustafa Cengiz Yakıcıer, Kamil Can Akçalı (2010); Flt3 may function as a link between liver regeneration and hepatocellular carcinogenesis EASL Monothematic Conference, Feb 2010, Amsterdam / The Netherlands Tolga Acun, M. Cengiz YAKICIER; (2008) Genetic and Epigenetic Analysis of Epithelial Cell Senescence Pathway Genes in Hepatocellular Carcinoma 8 th National Medical Genetic Congress with International Participation, May 2008, Canakkale / Türkiye * Best Study Award (Oral Presentation) RNA in Disease and Therapy ; (2006) International University of Andalusia Workshops Current Trends in Biomedicine, October 2006, Baeza / Spain Acun T., Kaya K.D., Konu Ö. and Yakicier M.C.; (2006) "Prediction of new Fugu rubripes mirnas" Workshop on "Emerging Topics in Human Functional Genomics and Proteomics", March 2006, Antalya / Turkey Projects 1. Analysis of HLJ1(DNAJB4) as a new biomarker candidate in cancers, Bulent Ecevit University, Scientific Research Project (BAP) No: , 2013 ongoing, Principle Investigator 2. Investigation of Molecular Genetic Changes in Hepatocellular Carcinomas, TUBITAK* Project No:107S174, 2009, Researcher student (with fellowship from TUBITAK). 3. Genetic Analysis of MAPK Pathway in Hepatocellular Carcinomas, TUBITAK, Project No: TBAG-HD/134, 106T203, 2008, Researcher student. 4. Epithelial Senescence and Cancer, TUBITAK, Project No: SBAG-2774/104S045, 2006, Researcher/Specialist. ( (*) TUBITAK; Scientific and Technological Research Council of Turkey 4

5 Teaching Experience * Bülent Ecevit University (as an Assistant Prof. Dr.) BMM105 Biology for Engineers (2012, 2013) MBG101 General Biology-I (2013) MBG103 General Biology Laboratory-I (2013) * Bilkent University (as a Teaching Assistant) MBG-418 Genomics (2010) MBG-210 Genetics ( ) MBG-223 Molecular Genetics (2003) Lab Skills Molecular Biology techniques *DNA-RNA isolation, *PCR, *Q-RT-PCR, *multiplex semi-q-rt-pcr, *RFLP, *Sodium Bisulfite Treatment, *Combined Bisulfite Restriction Analysis (COBRA), *Native and SDS Polyacrylamide Gel Electrophoresis Protein assays *Western Blotting, *immunohistochemistry, *glyco detection, *peptide mapping, *HPLC Applications (with Perfusion Chromatography Workstation, BioCAD 700E), *isoelectric focusing, *coomassie blue and silver staining. Cell culture techniques Basic microbiology techniques Maintenance and basic experiments with the model organisms C. elegans, D. melanogaster, yeast (H. anemola, S. cerevisiae) Small animal handling * Have an accredited certificate from Care & Use of Laboratory Animal Course Bilkent University, Bioinformatics tools [ primer design, BLAST, PyMOL, multiple alignment, mutation analysis, restriction analysis ], and databases [ NCBI, Ensembl, UCSC, Sanger ]. 5

6 Fellowships and Awards 2012 Visiting Scientist Fellowship from Turkish Council of Higher Education Duration: 3 months Host: Diego ARANGO, Ph.D. Head, Group of Molecular Oncology, Molecular Biology and Biochemistry Research Center, CIBBIM-Nanomedicine, Vall d'hebron Hospital Research Institute, Barcelona, SPAIN. mail: darango@ir.vhebron.net Full Ph.D. fellowship from Bilkent University Best Study Award ( Oral Presentation ) 8th National Medical Genetic Congress with International Participation, May 2008, Canakkale / Türkiye Researcher bursarie ; TUBITAK Project No: 107S Student fellowship ; ILCA 1 st Annual Conference, (Barcelona / Spain) 2006 Student fellowship ; FEBS 31 st Annual Congress, (Istanbul / Turkey) Memberships European Association for Cancer Research (EACR) The Association for Molecular Cancer Research, Turkey (MOKAD) Molecular Biology Association (MBD) Hobies Squash, photography, cooking 6

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